TB-Profiler result

Run: SRR13861332
Summary

Run ID: SRR13861332

Sample name:

Date: 2024-04-15T02:58:37.383921

Number of reads: 1752208

Percentage reads mapped: 43.85

Median coverage: 60.0

Strain: lineage4.9

Spoligotype:

Drug-resistance: Other

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage4 Euro-American None 0.97
lineage4.9 Euro-American (H37Rv-like) None 0.97
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol
pyrazinamide
streptomycin rrs n.462C>T Uncertain significance Mutation from literature
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid fgd1 c.730_732delAACinsGG Assoc w R - Interim Confers DLM-PMD cross-resistance
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
fgd1 491512 c.730_732delAACinsGG frameshift_variant&missense_variant 0.15 delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
rrs 1472307 n.462C>T non_coding_transcript_exon_variant 0.16 streptomycin Uncertain significance Mutation from literature
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
dnaA 375 p.Asp125Glu missense_variant 1.0 isoniazid
dnaA 729 c.729C>G synonymous_variant 0.15 isoniazid Not assoc w R - Interim
dnaA 750 c.750C>G synonymous_variant 0.15 isoniazid
dnaA 756 c.756T>C synonymous_variant 0.14 isoniazid
dnaA 786 c.786C>T synonymous_variant 0.14 isoniazid
dnaA 813 c.813C>T synonymous_variant 0.16 isoniazid
dnaA 828 c.828T>C synonymous_variant 0.14 isoniazid Not assoc w R - Interim
dnaA 840 c.840G>A synonymous_variant 0.13 isoniazid
dnaA 1161 c.1161A>G synonymous_variant 0.17 isoniazid
dnaA 1164 c.1164A>C synonymous_variant 0.17 isoniazid
dnaA 1167 c.1167A>G synonymous_variant 0.17 isoniazid Not assoc w R - Interim
dnaA 1176 c.1176A>G synonymous_variant 0.17 isoniazid
dnaA 1177 p.Ala393Ser missense_variant 0.17 isoniazid
dnaA 1191 c.1191T>C synonymous_variant 0.16 isoniazid
dnaA 1197 c.1197T>G synonymous_variant 0.17 isoniazid
dnaA 1204 c.1204C>T synonymous_variant 0.18 isoniazid
dnaA 1209 c.1209C>T synonymous_variant 0.19 isoniazid Not assoc w R - Interim
dnaA 1220 p.Asn407Ser missense_variant 0.19 isoniazid
dnaA 1230 c.1230A>G synonymous_variant 0.18 isoniazid
dnaA 1245 c.1245G>C synonymous_variant 0.15 isoniazid Not assoc w R - Interim
dnaA 1254 c.1254T>C synonymous_variant 0.15 isoniazid
gyrB 4996 c.-244A>C upstream_gene_variant 1.0 levofloxacin
moxifloxacin
gyrB 5258 p.Lys7* stop_gained 1.0 levofloxacin Uncertain significance
moxifloxacin
gyrB 7122 c.1883_1884insA frameshift_variant 1.0 levofloxacin Uncertain significance
moxifloxacin
gyrA 7571 c.270G>C synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7585 p.Ser95Thr missense_variant 0.14 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7595 c.294C>G synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 7607 c.306C>G synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7626 c.325C>T synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 7631 c.330G>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 7637 c.336C>G synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 7649 c.348C>T synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 7652 c.351C>T synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 7658 c.357A>G synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 7664 c.363T>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 7670 c.369A>G synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 7676 c.375G>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 7683 c.382A>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 7694 c.393A>G synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 7697 c.396C>G synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 7710 c.409T>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 7715 c.414G>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 7728 c.427_429delAGGinsCC frameshift_variant&missense_variant 0.17 levofloxacin
moxifloxacin
gyrA 7763 c.462T>C synonymous_variant 0.14 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8156 c.855T>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8204 c.903C>T synonymous_variant 0.14 levofloxacin
moxifloxacin
gyrA 8216 c.915G>A synonymous_variant 0.14 levofloxacin
moxifloxacin
gyrA 8225 c.924T>C synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 8234 c.933T>G synonymous_variant 0.14 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8237 c.936A>G synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 8253 p.Ile318Leu missense_variant 0.18 levofloxacin
moxifloxacin
gyrA 8264 c.963T>C synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 8267 c.966G>C synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8270 c.969G>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8324 c.1023T>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8339 c.1038A>G synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8342 c.1041G>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8366 c.1065G>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8375 c.1074G>C synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 8399 c.1098T>C synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8903 c.1602T>C synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8915 c.1614A>G synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8987 c.1686C>G synonymous_variant 0.14 levofloxacin
moxifloxacin
gyrA 8990 c.1689C>G synonymous_variant 0.14 levofloxacin
moxifloxacin
Rv0010c 13577 c.-19G>T upstream_gene_variant 1.0 isoniazid
fgd1 491502 c.720G>A synonymous_variant 0.15 clofazimine
pretomanid
delamanid
fgd1 491508 c.726A>G synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fgd1 491509 c.727T>C synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fgd1 491550 c.768T>C synonymous_variant 0.15 clofazimine
pretomanid
delamanid
mshA 575623 c.276C>G synonymous_variant 0.17 ethionamide
isoniazid
mshA 575629 c.282A>C synonymous_variant 0.16 ethionamide
isoniazid
mshA 575635 c.288A>C synonymous_variant 0.16 ethionamide
isoniazid Not assoc w R - Interim
mshA 575638 c.291T>C synonymous_variant 0.16 ethionamide
isoniazid
mshA 575641 c.294A>G synonymous_variant 0.16 ethionamide
isoniazid
mshA 575648 p.Val101Gln missense_variant 0.17 ethionamide
isoniazid
mshA 575659 c.312A>G synonymous_variant 0.2 ethionamide
isoniazid
mshA 575665 c.318G>C synonymous_variant 0.2 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
mshA 575695 c.348C>G synonymous_variant 0.17 ethionamide
isoniazid Not assoc w R - Interim
mshA 575704 c.357T>C synonymous_variant 0.17 ethionamide
isoniazid
mshA 575705 c.358T>C synonymous_variant 0.17 ethionamide
isoniazid
mshA 575713 c.366G>A synonymous_variant 0.2 ethionamide
isoniazid
mshA 575719 c.372C>T synonymous_variant 0.23 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
mshA 575734 c.387T>G synonymous_variant 0.23 ethionamide
isoniazid
mshA 575737 c.390T>C synonymous_variant 0.22 ethionamide
isoniazid
mshA 575746 c.399C>G synonymous_variant 0.22 ethionamide
isoniazid
mshA 575752 c.405G>A synonymous_variant 0.19 ethionamide
isoniazid Not assoc w R - Interim
mshA 575767 c.420G>A synonymous_variant 0.16 ethionamide
isoniazid
mshA 575771 p.Val142Ser missense_variant 0.16 ethionamide
isoniazid
mshA 575779 c.432A>G synonymous_variant 0.17 ethionamide
isoniazid
ccsA 620646 c.756G>A synonymous_variant 0.15 capreomycin
amikacin
kanamycin
ccsA 620661 c.771C>G synonymous_variant 0.15 capreomycin
amikacin
kanamycin
ccsA 620703 c.813G>C synonymous_variant 0.17 capreomycin
amikacin
kanamycin
ccsA 620710 c.820_822delGTGinsAC frameshift_variant&missense_variant 0.15 capreomycin
amikacin
kanamycin
ccsA 620730 c.840C>T synonymous_variant 0.14 capreomycin
amikacin
kanamycin
ccsA 620734 c.844C>A synonymous_variant 0.14 capreomycin
amikacin
kanamycin
Rv0565c 656922 c.547_549delATCinsGG frameshift_variant&missense_variant 0.17 ethionamide Uncertain significance
Rv0565c 656934 c.537C>G synonymous_variant 0.15 ethionamide
Rv0565c 656943 c.528G>C synonymous_variant 0.15 ethionamide
Rv0565c 656946 c.525T>C synonymous_variant 0.15 ethionamide
Rv0565c 656952 c.519A>C synonymous_variant 0.14 ethionamide Not assoc w R - Interim
Rv0565c 657242 p.Glu77Lys missense_variant 0.13 ethionamide
Rv0565c 657261 c.210C>A synonymous_variant 0.13 ethionamide Not assoc w R - Interim
hadA 732308 p.Val127Ile missense_variant 0.15 isoniazid
hadA 732321 p.Glu131Ala missense_variant 0.16 isoniazid
hadA 732329 p.Leu134Val missense_variant 0.18 isoniazid Uncertain significance
hadA 732337 c.408G>A synonymous_variant 0.18 isoniazid
hadA 732346 c.417T>C synonymous_variant 0.18 isoniazid
nusG 734424 c.171G>A synonymous_variant 0.15 rifampicin
nusG 734442 c.189G>A synonymous_variant 0.21 rifampicin
nusG 734457 c.204C>G synonymous_variant 0.22 rifampicin
nusG 734472 c.219T>C synonymous_variant 0.22 rifampicin
nusG 734475 c.222T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
nusG 734481 c.228C>G synonymous_variant 0.23 rifampicin
nusG 734499 c.246G>C synonymous_variant 0.24 rifampicin
nusG 734532 c.279A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
nusG 734541 c.288A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
nusG 734559 c.306T>C synonymous_variant 0.19 rifampicin
nusG 734580 c.327T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
nusG 734610 c.357C>G synonymous_variant 0.15 rifampicin
nusG 734625 c.372T>C synonymous_variant 0.17 rifampicin
nusG 734634 c.381G>C synonymous_variant 0.16 rifampicin
nusG 734643 c.390G>C synonymous_variant 0.15 rifampicin
nusG 734841 c.588G>A synonymous_variant 0.13 rifampicin
rpoB 760196 c.390C>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 760235 c.429T>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 760307 c.501T>C synonymous_variant 0.15 rifampicin
rpoB 760406 c.600G>C synonymous_variant 0.19 rifampicin
rpoB 760418 c.612G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760982 c.1176G>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 760985 c.1179G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761015 c.1209G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761021 c.1215G>C synonymous_variant 0.19 rifampicin
rpoB 761027 c.1221A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 761036 c.1230G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 761051 c.1245G>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 761054 c.1248G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761057 c.1251G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761060 c.1254C>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 761063 c.1257C>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 761094 c.1288C>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 761150 c.1344A>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 761183 c.1377T>G synonymous_variant 0.14 rifampicin
rpoB 761222 c.1416G>C synonymous_variant 0.15 rifampicin
rpoB 761261 c.1455G>T synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 762083 c.2277T>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 762101 c.2295C>G synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 762131 c.2325C>G synonymous_variant 0.15 rifampicin
rpoB 762143 c.2337T>C synonymous_variant 0.15 rifampicin
rpoB 762149 c.2343G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 762167 c.2361T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 762176 c.2370T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 762185 c.2379G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 762218 c.2412T>G synonymous_variant 0.17 rifampicin
rpoB 762254 c.2448T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 762266 c.2460T>C synonymous_variant 0.2 rifampicin
rpoB 762284 c.2478G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 762293 c.2487T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 762317 c.2511A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 762329 c.2523G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 762338 c.2532T>C synonymous_variant 0.17 rifampicin
rpoB 762347 c.2541T>C synonymous_variant 0.18 rifampicin
rpoB 762362 p.Glu852Asp missense_variant 0.16 rifampicin
rpoB 762369 c.2563T>C synonymous_variant 0.16 rifampicin
rpoC 762374 c.-996G>C upstream_gene_variant 0.17 rifampicin
rpoC 762380 c.-990T>G upstream_gene_variant 0.18 rifampicin
rpoC 762395 c.-975G>C upstream_gene_variant 0.16 rifampicin
rpoC 762398 c.-972T>C upstream_gene_variant 0.17 rifampicin
rpoC 762401 c.-969G>C upstream_gene_variant 0.16 rifampicin
rpoB 762404 c.2598T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 762410 c.-960T>C upstream_gene_variant 0.15 rifampicin
rpoB 762416 c.2610A>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 762443 c.-927G>C upstream_gene_variant 0.16 rifampicin
rpoB 763040 c.3234C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 763070 c.3264T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 763486 c.117T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 763528 c.159G>A synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 763594 c.225C>T synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 763633 c.264T>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 763636 c.267T>C synonymous_variant 0.14 rifampicin
rpoC 763642 c.273G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 763658 p.Leu97Phe missense_variant 0.15 rifampicin Uncertain significance
rpoC 764131 c.762T>C synonymous_variant 0.15 rifampicin
rpoC 764196 p.Ser276* stop_gained 0.13 rifampicin
rpoC 765404 p.Leu679Val missense_variant 0.15 rifampicin
rpoC 765421 c.2052C>G synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoC 765451 c.2082C>G synonymous_variant 0.18 rifampicin
rpoC 765452 c.2083_2085delGCCinsTG frameshift_variant&missense_variant 0.18 rifampicin
rpoC 765478 c.2109T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 765499 c.2130C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 765508 c.2139C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 765541 c.2172C>G synonymous_variant 0.21 rifampicin
rpoC 765553 c.2184C>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 765556 c.2187G>C synonymous_variant 0.2 rifampicin
rpoC 765559 c.2190G>C synonymous_variant 0.2 rifampicin
rpoC 765578 c.2209C>T synonymous_variant 0.18 rifampicin
rpoC 765583 c.2214G>T synonymous_variant 0.18 rifampicin
rpoC 765613 p.His748Gln missense_variant 0.17 rifampicin
rpoC 765625 c.2256C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 765628 c.2259G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 765631 p.Asp754Glu missense_variant 0.17 rifampicin
rpoC 765967 c.2598C>T synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoC 765970 c.2601C>T synonymous_variant 0.13 rifampicin
rpoC 765985 c.2616C>T synonymous_variant 0.14 rifampicin
rpoC 765994 c.2625A>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 766309 c.2940G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 766312 c.2943T>G synonymous_variant 0.15 rifampicin
rpoC 766315 c.2946C>G synonymous_variant 0.15 rifampicin
rpoC 766327 c.2958C>G synonymous_variant 0.17 rifampicin
rpoC 766345 c.2976T>C synonymous_variant 0.18 rifampicin
rpoC 766348 c.2979A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 766363 c.2994G>C synonymous_variant 0.18 rifampicin
rpoC 766381 c.3012C>T synonymous_variant 0.22 rifampicin
rpoC 766384 c.3015A>G synonymous_variant 0.23 rifampicin
rpoC 766390 c.3021C>T synonymous_variant 0.23 rifampicin
rpoC 766408 c.3039C>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 766426 c.3057C>T synonymous_variant 0.27 rifampicin
rpoC 766447 c.3078T>C synonymous_variant 0.24 rifampicin
rpoC 766483 c.3114G>C synonymous_variant 0.2 rifampicin
rpoC 766484 c.3115_3117delGTAinsAC frameshift_variant&missense_variant 0.2 rifampicin
rpoC 766492 c.3123T>C synonymous_variant 0.2 rifampicin
rpoC 766495 c.3126C>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 766522 c.3153C>G synonymous_variant 0.2 rifampicin
rpoC 766528 c.3159T>C synonymous_variant 0.17 rifampicin
rpoC 766531 c.3162G>T synonymous_variant 0.18 rifampicin
rpoC 766543 c.3174C>T synonymous_variant 0.18 rifampicin
rpoC 766549 c.3180G>C synonymous_variant 0.18 rifampicin
rpoC 766801 c.3432C>A synonymous_variant 0.13 rifampicin
rpoC 766843 c.3474T>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 766861 c.3492G>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 766933 c.3564A>G synonymous_variant 0.15 rifampicin
rpoC 767062 c.3693C>A synonymous_variant 0.14 rifampicin
rpoC 767098 c.3729T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 767119 c.3750A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 767134 c.3765C>G synonymous_variant 0.15 rifampicin
rpoC 767158 c.3789T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 767167 c.3798C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
mmpL5 776374 p.Arg703Cys missense_variant 1.0 clofazimine
bedaquiline
mmpR5 779126 p.Cys46Phe missense_variant 1.0 clofazimine
bedaquiline
rpsL 781859 c.300T>C synonymous_variant 0.15 streptomycin Not assoc w R - Interim
rpsL 781868 c.309T>C synonymous_variant 0.15 streptomycin
rplC 800516 c.-293G>T upstream_gene_variant 0.13 linezolid
rplC 800537 c.-272C>T upstream_gene_variant 0.14 linezolid
rplC 800567 c.-242A>G upstream_gene_variant 0.17 linezolid
rplC 800582 c.-227C>G upstream_gene_variant 0.18 linezolid
rplC 800612 c.-197A>G upstream_gene_variant 0.22 linezolid
rplC 800618 c.-191T>C upstream_gene_variant 0.24 linezolid
rplC 800648 c.-161A>C upstream_gene_variant 0.2 linezolid
rplC 800654 c.-155T>C upstream_gene_variant 0.2 linezolid
rplC 801447 p.Lys213Asn missense_variant 0.97 linezolid
Rv1129c 1253197 c.1338C>A synonymous_variant 1.0 moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv1129c 1253317 c.1218G>A synonymous_variant 1.0 moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv1129c 1253639 p.Leu299* stop_gained 1.0 moxifloxacin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
fbiC 1303004 p.Ala25Glu missense_variant 1.0 clofazimine
pretomanid
delamanid
fbiC 1303171 p.Arg81Trp missense_variant 1.0 clofazimine
pretomanid
delamanid
fbiC 1303517 p.Met196Thr missense_variant 0.94 clofazimine
pretomanid
delamanid
fbiC 1303818 c.888C>G synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1303836 c.906G>C synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1303845 c.915C>G synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1303846 p.Phe306Val missense_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1303854 c.924T>C synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1303860 c.930A>C synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1303881 c.951G>C synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1303884 c.954T>G synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1303911 c.981G>C synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1303914 c.984C>G synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1303920 c.990C>G synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1303923 c.993C>T synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1303929 c.999G>C synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1303947 c.1017T>C synonymous_variant 0.15 clofazimine
pretomanid
delamanid
fbiC 1303948 p.Gly340Arg missense_variant 0.15 clofazimine
pretomanid
delamanid
fbiC 1304034 c.1104A>G synonymous_variant 0.14 clofazimine
pretomanid
delamanid
fbiC 1304703 c.1773C>G synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1304715 c.1785G>C synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1304724 c.1794A>G synonymous_variant 0.18 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1304727 c.1797A>G synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1304742 c.1812T>C synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1305311 p.Arg794Gln missense_variant 0.13 clofazimine
pretomanid
delamanid
fbiC 1305331 p.Glu801Lys missense_variant 0.14 clofazimine
pretomanid
delamanid
sigE 1364919 c.507T>C synonymous_variant 0.14 pyrazinamide
Rv1258c 1407597 c.-257C>G upstream_gene_variant 1.0 streptomycin
isoniazid
pyrazinamide
rrs 1471970 n.125G>A non_coding_transcript_exon_variant 0.13 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrl 1473806 n.149C>T non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473813 n.156C>T non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
rrl 1473877 n.220G>A non_coding_transcript_exon_variant 0.13 capreomycin
linezolid
rrl 1473898 n.241C>T non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473899 n.242A>C non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473937 n.280C>T non_coding_transcript_exon_variant 0.14 capreomycin Uncertain significance
linezolid
rrl 1473944 n.287G>A non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
rrl 1473945 n.288T>C non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
rrl 1473981 n.324delGinsTT non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
rrl 1474001 n.344C>T non_coding_transcript_exon_variant 0.15 capreomycin Not assoc w R
linezolid Not assoc w R
rrl 1474009 n.352A>G non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
rrl 1474012 n.355C>T non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1474956 n.1299C>T non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1474959 n.1302C>T non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1474962 n.1306delG non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1474970 n.1313G>A non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1474991 n.1334T>C non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1475006 n.1349A>T non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1475015 n.1358C>T non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1475061 n.1404C>T non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid
rrl 1475088 n.1431A>T non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1475199 n.1542G>A non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
rrl 1475206 n.1549C>T non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid
rrl 1475209 n.1552G>C non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid
rrl 1475213 n.1556C>T non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid
rrl 1475505 n.1848G>A non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475599 n.1942A>G non_coding_transcript_exon_variant 0.17 capreomycin
linezolid Uncertain significance
rrl 1475608 n.1951T>C non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid
rrl 1475638 n.1981C>T non_coding_transcript_exon_variant 0.15 capreomycin
linezolid
rrl 1475642 n.1985T>C non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
rrl 1475659 n.2002G>T non_coding_transcript_exon_variant 0.15 capreomycin
linezolid
rrl 1475763 n.2106C>T non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid
rrl 1475881 n.2224T>C non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
rrl 1476025 n.2368G>T non_coding_transcript_exon_variant 0.14 capreomycin
linezolid
rrl 1476336 n.2679C>T non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1476356 n.2699C>A non_coding_transcript_exon_variant 0.27 capreomycin
linezolid
rrl 1476357 n.2700T>C non_coding_transcript_exon_variant 0.27 capreomycin
linezolid
rrl 1476358 n.2701T>C non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476359 n.2702C>G non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476369 n.2712C>T non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476381 n.2724G>C non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476382 n.2725A>G non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476383 n.2726T>G non_coding_transcript_exon_variant 0.31 capreomycin
linezolid
rrl 1476384 n.2727G>T non_coding_transcript_exon_variant 0.31 capreomycin
linezolid
rrl 1476408 n.2751G>A non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476411 n.2754G>A non_coding_transcript_exon_variant 0.29 capreomycin
linezolid
rrl 1476425 n.2768G>A non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476429 n.2772A>C non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476442 n.2785T>A non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1476443 n.2786G>T non_coding_transcript_exon_variant 0.27 capreomycin
linezolid
rrl 1476455 n.2798C>A non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1476456 n.2799A>T non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1476463 n.2806C>T non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1476466 n.2809C>T non_coding_transcript_exon_variant 0.24 capreomycin Not assoc w R
linezolid Uncertain significance
rpsA 1833841 c.300C>G synonymous_variant 0.14 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.15 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.17 pyrazinamide
rpsA 1833862 c.321G>T synonymous_variant 0.16 pyrazinamide
rpsA 1833874 c.333T>C synonymous_variant 0.17 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.15 pyrazinamide
rpsA 1833940 c.399C>G synonymous_variant 0.18 pyrazinamide
rpsA 1833970 c.429G>C synonymous_variant 0.18 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.17 pyrazinamide
rpsA 1834396 c.855G>C synonymous_variant 0.14 pyrazinamide
rpsA 1834417 c.876G>C synonymous_variant 0.16 pyrazinamide
rpsA 1834423 c.882G>C synonymous_variant 0.15 pyrazinamide
rpsA 1834474 c.933C>G synonymous_variant 0.16 pyrazinamide
rpsA 1834489 c.948T>C synonymous_variant 0.16 pyrazinamide
rpsA 1834498 c.957C>T synonymous_variant 0.17 pyrazinamide
rpsA 1834528 c.987T>C synonymous_variant 0.19 pyrazinamide
rpsA 1834546 c.1005T>C synonymous_variant 0.19 pyrazinamide
rpsA 1834555 c.1014T>C synonymous_variant 0.19 pyrazinamide
rpsA 1834558 c.1017C>G synonymous_variant 0.21 pyrazinamide
rpsA 1834606 c.1065C>G synonymous_variant 0.22 pyrazinamide
rpsA 1834609 c.1068T>C synonymous_variant 0.2 pyrazinamide
rpsA 1834633 c.1092A>G synonymous_variant 0.16 pyrazinamide
rpsA 1834639 c.1098T>C synonymous_variant 0.21 pyrazinamide
rpsA 1834640 p.Glu367* stop_gained 0.79 pyrazinamide Uncertain significance
rpsA 1834666 c.1125G>C synonymous_variant 0.21 pyrazinamide
rpsA 1834669 c.1128G>C synonymous_variant 0.22 pyrazinamide
rpsA 1834688 c.1147_1149delAGTinsTCC synonymous_variant 0.19 pyrazinamide
rpsA 1834732 c.1191T>C synonymous_variant 0.17 pyrazinamide
rpsA 1834733 p.Ala398Pro missense_variant 0.17 pyrazinamide
tsnR 1853394 c.-212C>G upstream_gene_variant 0.15 linezolid
tsnR 1853420 c.-186T>G upstream_gene_variant 0.16 linezolid
tsnR 1853429 c.-177G>C upstream_gene_variant 0.18 linezolid
tsnR 1853432 c.-174G>C upstream_gene_variant 0.16 linezolid
tsnR 1853447 c.-159C>G upstream_gene_variant 0.15 linezolid
tsnR 1853450 c.-156G>A upstream_gene_variant 0.14 linezolid
tsnR 1853459 c.-147G>C upstream_gene_variant 0.14 linezolid
bacA 2064395 p.Thr112Pro missense_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064589 c.139delT frameshift_variant 1.0 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
ndh 2103004 c.39T>G synonymous_variant 1.0 ethionamide
delamanid
isoniazid
PPE35 2170453 p.Gly54Ser missense_variant 1.0 pyrazinamide
Rv1979c 2223326 c.-162C>T upstream_gene_variant 1.0 clofazimine
bedaquiline
Rv1979c 2223365 c.-201C>A upstream_gene_variant 1.0 clofazimine
bedaquiline
pncA 2288748 p.Ala165Asp missense_variant 1.0 pyrazinamide
kasA 2518474 p.Glu120Asp missense_variant 0.95 isoniazid
kasA 2518504 c.390T>C synonymous_variant 0.15 isoniazid
kasA 2518506 p.Ala131Glu missense_variant 0.15 isoniazid
kasA 2518513 c.399C>G synonymous_variant 0.17 isoniazid
kasA 2518519 c.405G>C synonymous_variant 0.16 isoniazid
kasA 2518528 c.414C>G synonymous_variant 0.17 isoniazid
kasA 2518540 c.426T>G synonymous_variant 0.17 isoniazid
kasA 2518561 c.447T>C synonymous_variant 0.18 isoniazid
kasA 2518567 c.453G>C synonymous_variant 0.18 isoniazid
kasA 2518570 c.456G>C synonymous_variant 0.17 isoniazid
kasA 2518574 c.460_462delATCinsGG frameshift_variant&missense_variant 0.17 isoniazid
kasA 2518588 c.474T>C synonymous_variant 0.19 isoniazid
kasA 2518591 c.477G>C synonymous_variant 0.19 isoniazid
kasA 2518609 p.Met165Ile missense_variant 0.2 isoniazid
kasA 2518621 c.507G>A synonymous_variant 0.19 isoniazid
kasA 2518663 c.549T>C synonymous_variant 0.15 isoniazid
kasA 2518672 c.558G>C synonymous_variant 0.16 isoniazid
kasA 2518687 c.573C>T synonymous_variant 0.15 isoniazid
kasA 2518696 c.582C>G synonymous_variant 0.17 isoniazid
kasA 2518702 c.588C>T synonymous_variant 0.17 isoniazid
kasA 2518711 c.597A>G synonymous_variant 0.18 isoniazid
kasA 2518714 c.600A>C synonymous_variant 0.18 isoniazid
kasA 2518717 c.603C>T synonymous_variant 0.19 isoniazid
kasA 2518723 p.Glu203Asp missense_variant 0.18 isoniazid
kasA 2518732 c.618C>G synonymous_variant 0.18 isoniazid
kasA 2518741 c.627G>C synonymous_variant 0.19 isoniazid
kasA 2518747 c.633C>G synonymous_variant 0.19 isoniazid
kasA 2518768 c.654C>G synonymous_variant 0.18 isoniazid
kasA 2518783 c.669T>C synonymous_variant 0.16 isoniazid
kasA 2518792 c.678C>G synonymous_variant 0.16 isoniazid
kasA 2518795 c.681C>G synonymous_variant 0.15 isoniazid
Rv2477c 2783040 p.Ala335Thr missense_variant 0.18 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
kanamycin Uncertain significance
rifampicin Uncertain significance
amikacin Uncertain significance
Rv2477c 2783068 p.Asp325Glu missense_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783077 c.966T>C synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783092 c.951A>G synonymous_variant 0.18 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783095 c.948C>G synonymous_variant 0.2 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R
amikacin Not assoc w R - Interim
Rv2477c 2783110 c.933C>A synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783116 c.927T>C synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783140 c.903C>G synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783158 c.885A>G synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783194 c.849A>G synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783628 p.Ala139Ser missense_variant 0.14 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783629 c.414C>T synonymous_variant 0.14 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783656 c.387G>C synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783691 c.352C>T synonymous_variant 0.16 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783700 p.Thr115Ser missense_variant 0.15 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783719 c.324A>G synonymous_variant 0.15 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783751 p.Ile98Val missense_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783758 p.Asp95Glu missense_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783761 c.282G>C synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783766 p.Met93Leu missense_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783773 c.270A>G synonymous_variant 0.17 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783776 c.267G>C synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783779 c.264T>C synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783794 c.249G>A synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783797 p.Asp82Glu missense_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783815 c.228A>G synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783833 c.210G>C synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783843 p.Gly67Asp missense_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783860 p.Asp61Glu missense_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783863 c.180C>T synonymous_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783883 c.160T>C synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783884 c.159T>C synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783887 c.156C>G synonymous_variant 0.2 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783920 c.123G>C synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2752c 3066024 c.168T>C synonymous_variant 0.17 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
thyX 3067244 c.702C>G synonymous_variant 0.15 para-aminosalicylic_acid
thyX 3067250 c.694_696delGTGinsAC frameshift_variant&missense_variant 0.15 para-aminosalicylic_acid
thyX 3067277 c.669C>G synonymous_variant 0.16 para-aminosalicylic_acid
thyX 3067280 c.666G>C synonymous_variant 0.15 para-aminosalicylic_acid
thyX 3067284 p.Ala221Asp missense_variant 0.15 para-aminosalicylic_acid
thyX 3067293 p.Gln218Arg missense_variant 0.14 para-aminosalicylic_acid
thyX 3067304 c.642A>G synonymous_variant 0.15 para-aminosalicylic_acid
thyX 3067316 c.630A>G synonymous_variant 0.14 para-aminosalicylic_acid
thyX 3067355 c.591A>C synonymous_variant 0.16 para-aminosalicylic_acid
thyX 3067529 c.417C>G synonymous_variant 0.88 para-aminosalicylic_acid
thyX 3067619 c.327A>C synonymous_variant 0.14 para-aminosalicylic_acid
thyX 3067661 c.285C>G synonymous_variant 0.15 para-aminosalicylic_acid
thyX 3067688 c.258G>C synonymous_variant 0.15 para-aminosalicylic_acid
thyX 3067694 c.252G>C synonymous_variant 0.15 para-aminosalicylic_acid
thyX 3067718 c.228C>G synonymous_variant 0.19 para-aminosalicylic_acid
thyX 3067721 c.225T>C synonymous_variant 0.19 para-aminosalicylic_acid
thyX 3067724 c.222G>A synonymous_variant 0.18 para-aminosalicylic_acid
thyX 3067727 c.219A>C synonymous_variant 0.18 para-aminosalicylic_acid
thyX 3067739 c.207T>C synonymous_variant 0.19 para-aminosalicylic_acid
thyX 3067742 c.204A>C synonymous_variant 0.19 para-aminosalicylic_acid
thyX 3067761 p.Arg62Lys missense_variant 0.17 para-aminosalicylic_acid
thyX 3067765 p.Leu61Ile missense_variant 0.17 para-aminosalicylic_acid
thyX 3067781 c.165C>G synonymous_variant 0.18 para-aminosalicylic_acid
thyX 3067787 c.159G>A synonymous_variant 0.16 para-aminosalicylic_acid
thyX 3067793 c.153T>C synonymous_variant 0.15 para-aminosalicylic_acid
thyX 3067799 c.147G>A synonymous_variant 0.15 para-aminosalicylic_acid
thyX 3067802 c.144C>G synonymous_variant 0.15 para-aminosalicylic_acid
thyA 3073764 c.708T>C synonymous_variant 1.0 para-aminosalicylic_acid
thyA 3073862 p.Gly204Ser missense_variant 0.87 para-aminosalicylic_acid
thyA 3073892 c.580T>C synonymous_variant 0.17 para-aminosalicylic_acid
thyA 3073893 c.579C>G synonymous_variant 0.18 para-aminosalicylic_acid
thyA 3073925 c.547T>C synonymous_variant 0.19 para-aminosalicylic_acid
thyA 3073926 c.546G>C synonymous_variant 0.19 para-aminosalicylic_acid
thyA 3073929 c.543T>C synonymous_variant 0.19 para-aminosalicylic_acid
thyA 3073953 c.519T>C synonymous_variant 0.22 para-aminosalicylic_acid
thyA 3073963 p.Leu170Gln missense_variant 0.77 para-aminosalicylic_acid
thyA 3073977 c.495A>G synonymous_variant 0.25 para-aminosalicylic_acid
thyA 3073989 c.483T>C synonymous_variant 0.22 para-aminosalicylic_acid
thyA 3074001 c.471C>G synonymous_variant 0.2 para-aminosalicylic_acid
thyA 3074004 c.468T>C synonymous_variant 0.2 para-aminosalicylic_acid
thyA 3074010 c.462C>G synonymous_variant 0.19 para-aminosalicylic_acid
thyA 3074031 c.441T>C synonymous_variant 0.17 para-aminosalicylic_acid
thyA 3074076 c.396C>G synonymous_variant 0.14 para-aminosalicylic_acid
thyA 3074117 c.355C>T synonymous_variant 0.15 para-aminosalicylic_acid
fbiD 3339357 c.240G>T synonymous_variant 1.0 clofazimine
pretomanid
delamanid
Rv3083 3448352 c.-152G>C upstream_gene_variant 1.0 ethionamide
Rv3083 3449624 p.Lys374Met missense_variant 1.0 ethionamide
Rv3083 3449919 c.1416C>A synonymous_variant 1.0 ethionamide
mtrB 3625755 p.Ala287Thr missense_variant 0.13 bedaquiline
rifampicin Uncertain significance
fbiB 3642227 p.Gln231His missense_variant 1.0 clofazimine
pretomanid
delamanid
fbiB 3642581 c.1047A>C synonymous_variant 1.0 clofazimine
pretomanid
delamanid
rpoA 3877542 c.966C>T synonymous_variant 0.16 rifampicin
rpoA 3877553 p.Glu319Gln missense_variant 0.16 rifampicin
rpoA 3877557 c.951C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoA 3877587 c.921A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3877613 p.Ile299Val missense_variant 0.2 rifampicin
rpoA 3877638 c.870T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoA 3877656 c.852T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoA 3877668 c.840A>G synonymous_variant 0.21 rifampicin
rpoA 3877677 p.Ala277Ser missense_variant 0.18 rifampicin
rpoA 3877680 c.828G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3877686 c.822A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3877692 c.816G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3877704 c.804G>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3877743 c.765T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3877764 c.744C>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoA 3877770 c.738A>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoA 3877776 c.732T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoA 3877782 c.726T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3877839 c.669G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoA 3877857 c.651G>A synonymous_variant 0.18 rifampicin
rpoA 3877866 c.642G>C synonymous_variant 0.17 rifampicin
rpoA 3877872 c.636C>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3877875 c.633T>G synonymous_variant 0.18 rifampicin
rpoA 3877899 p.Ser203Thr missense_variant 0.16 rifampicin
rpoA 3877905 c.603A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoA 3877908 p.Asn200Ser missense_variant 0.16 rifampicin
rpoA 3877953 c.555G>A synonymous_variant 0.18 rifampicin
rpoA 3877962 c.546G>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3878025 c.483C>T synonymous_variant 0.15 rifampicin
rpoA 3878028 c.480G>C synonymous_variant 0.16 rifampicin
rpoA 3878040 c.468T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3878049 c.459G>C synonymous_variant 0.16 rifampicin
rpoA 3878055 c.453A>G synonymous_variant 0.16 rifampicin
rpoA 3878061 c.447G>C synonymous_variant 0.18 rifampicin
rpoA 3878067 c.441C>G synonymous_variant 0.18 rifampicin
rpoA 3878070 c.438T>C synonymous_variant 0.18 rifampicin
rpoA 3878082 c.426T>C synonymous_variant 0.15 rifampicin
rpoA 3878094 c.414C>G synonymous_variant 0.15 rifampicin
rpoA 3878118 c.390T>C synonymous_variant 0.17 rifampicin
rpoA 3878169 c.339G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoA 3878184 c.324C>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoA 3878187 c.321C>G synonymous_variant 0.16 rifampicin
rpoA 3878193 c.315T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoA 3878199 c.309T>C synonymous_variant 0.17 rifampicin
rpoA 3878202 c.306G>C synonymous_variant 0.17 rifampicin
rpoA 3878217 c.291A>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoA 3878220 c.288C>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3878271 c.237T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoA 3878284 p.Glu75Ala missense_variant 0.18 rifampicin
rpoA 3878292 c.216T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3878304 c.204G>C synonymous_variant 0.17 rifampicin
rpoA 3878313 c.195G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoA 3878346 c.162T>C synonymous_variant 0.17 rifampicin
rpoA 3878826 c.-319A>T upstream_gene_variant 0.14 rifampicin
rpoA 3878845 c.-338G>T upstream_gene_variant 0.14 rifampicin
rpoA 3878853 c.-346G>A upstream_gene_variant 0.14 rifampicin
rpoA 3878894 c.-387A>G upstream_gene_variant 0.15 rifampicin
clpC1 4038278 c.2427T>C synonymous_variant 0.15 pyrazinamide
clpC1 4038293 c.2412G>C synonymous_variant 0.16 pyrazinamide
clpC1 4038302 c.2403C>G synonymous_variant 0.16 pyrazinamide
clpC1 4038308 c.2395_2397delGTGinsAC frameshift_variant&missense_variant 0.16 pyrazinamide
clpC1 4038317 c.2388G>C synonymous_variant 0.16 pyrazinamide
clpC1 4038347 c.2358G>C synonymous_variant 0.18 pyrazinamide
clpC1 4038359 c.2346A>G synonymous_variant 0.16 pyrazinamide
clpC1 4038368 c.2337T>C synonymous_variant 0.19 pyrazinamide
clpC1 4038398 c.2307G>T synonymous_variant 0.16 pyrazinamide
clpC1 4038403 c.2302T>C synonymous_variant 0.18 pyrazinamide Not assoc w R - Interim
clpC1 4038419 c.2286T>C synonymous_variant 0.17 pyrazinamide
clpC1 4038434 c.2271G>C synonymous_variant 0.15 pyrazinamide
clpC1 4038445 p.Ala754Thr missense_variant 0.14 pyrazinamide
clpC1 4038452 c.2253G>C synonymous_variant 0.18 pyrazinamide
clpC1 4038461 p.Ala748Asp missense_variant 0.17 pyrazinamide
clpC1 4038498 p.Ser736Thr missense_variant 0.17 pyrazinamide
clpC1 4038530 p.Glu725Asp missense_variant 0.15 pyrazinamide
clpC1 4038536 c.2169C>T synonymous_variant 0.15 pyrazinamide Not assoc w R - Interim
clpC1 4038596 c.2109A>G synonymous_variant 0.15 pyrazinamide
clpC1 4038611 c.2094C>T synonymous_variant 0.17 pyrazinamide
clpC1 4038623 c.2082A>G synonymous_variant 0.17 pyrazinamide
clpC1 4038640 p.Asp689Asn missense_variant 0.15 pyrazinamide
clpC1 4038653 c.2052C>T synonymous_variant 0.19 pyrazinamide
clpC1 4038658 p.Lys683Gln missense_variant 0.17 pyrazinamide
clpC1 4038661 p.Ser682Thr missense_variant 0.17 pyrazinamide
clpC1 4038662 c.2043T>C synonymous_variant 0.17 pyrazinamide
clpC1 4038671 c.2034T>C synonymous_variant 0.2 pyrazinamide
clpC1 4038683 c.2022T>C synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
clpC1 4038695 c.2010C>G synonymous_variant 0.21 pyrazinamide
clpC1 4038701 c.2004G>C synonymous_variant 0.18 pyrazinamide
clpC1 4038704 c.2001T>C synonymous_variant 0.19 pyrazinamide
clpC1 4038707 c.1998C>G synonymous_variant 0.19 pyrazinamide
clpC1 4038710 c.1995G>C synonymous_variant 0.19 pyrazinamide
clpC1 4038740 c.1965G>C synonymous_variant 0.19 pyrazinamide
clpC1 4038748 p.Arg653Cys missense_variant 0.16 pyrazinamide
clpC1 4038755 c.1950G>C synonymous_variant 0.17 pyrazinamide
clpC1 4038773 c.1932T>C synonymous_variant 0.18 pyrazinamide
clpC1 4038782 c.1923G>C synonymous_variant 0.18 pyrazinamide
clpC1 4038790 c.1915C>T synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
clpC1 4038812 c.1893T>C synonymous_variant 0.18 pyrazinamide
clpC1 4038815 c.1890G>T synonymous_variant 0.19 pyrazinamide
clpC1 4038851 c.1854G>A synonymous_variant 0.16 pyrazinamide
clpC1 4038878 c.1827A>G synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
clpC1 4038908 c.1797C>G synonymous_variant 0.17 pyrazinamide
clpC1 4038914 c.1791G>C synonymous_variant 0.18 pyrazinamide
clpC1 4038923 c.1782A>G synonymous_variant 0.19 pyrazinamide
clpC1 4038932 c.1773G>C synonymous_variant 0.19 pyrazinamide
clpC1 4038953 c.1752A>G synonymous_variant 0.15 pyrazinamide
clpC1 4038956 c.1749T>C synonymous_variant 0.16 pyrazinamide
clpC1 4038965 c.1740T>C synonymous_variant 0.17 pyrazinamide
clpC1 4038971 c.1734T>C synonymous_variant 0.16 pyrazinamide
clpC1 4038974 c.1731T>C synonymous_variant 0.16 pyrazinamide Not assoc w R - Interim
clpC1 4038989 c.1716T>C synonymous_variant 0.17 pyrazinamide
clpC1 4038997 c.1708T>C synonymous_variant 0.15 pyrazinamide Not assoc w R - Interim
clpC1 4039022 c.1683A>G synonymous_variant 0.2 pyrazinamide
clpC1 4039073 c.1632C>G synonymous_variant 0.17 pyrazinamide
clpC1 4039085 c.1620A>G synonymous_variant 0.2 pyrazinamide
clpC1 4039090 c.1615C>T synonymous_variant 0.2 pyrazinamide
clpC1 4039097 c.1608G>C synonymous_variant 0.21 pyrazinamide
clpC1 4039103 c.1602T>C synonymous_variant 0.18 pyrazinamide
clpC1 4039106 c.1599G>C synonymous_variant 0.17 pyrazinamide
clpC1 4039112 c.1593C>G synonymous_variant 0.16 pyrazinamide
clpC1 4039142 c.1563A>G synonymous_variant 0.16 pyrazinamide
clpC1 4039145 c.1560G>C synonymous_variant 0.16 pyrazinamide
clpC1 4039169 p.Glu512Asp missense_variant 0.14 pyrazinamide
clpC1 4039274 c.1431G>C synonymous_variant 0.16 pyrazinamide Not assoc w R - Interim
clpC1 4039286 c.1419T>C synonymous_variant 0.14 pyrazinamide
clpC1 4039289 c.1416T>C synonymous_variant 0.15 pyrazinamide
clpC1 4039463 c.1242C>G synonymous_variant 0.16 pyrazinamide
clpC1 4039466 c.1239T>C synonymous_variant 0.17 pyrazinamide
clpC1 4039469 c.1236T>C synonymous_variant 0.16 pyrazinamide
clpC1 4039481 c.1224T>G synonymous_variant 0.16 pyrazinamide Not assoc w R - Interim
clpC1 4039484 c.1221T>G synonymous_variant 0.14 pyrazinamide
clpC1 4039517 c.1188C>G synonymous_variant 0.18 pyrazinamide
clpC1 4039524 p.Phe394Tyr missense_variant 0.18 pyrazinamide
clpC1 4039526 c.1179G>C synonymous_variant 0.17 pyrazinamide
clpC1 4039547 c.1158C>G synonymous_variant 0.2 pyrazinamide
clpC1 4039553 c.1152C>G synonymous_variant 0.21 pyrazinamide
clpC1 4039562 c.1143C>G synonymous_variant 0.22 pyrazinamide
clpC1 4039565 c.1140G>C synonymous_variant 0.24 pyrazinamide
clpC1 4039576 p.Ala377Ser missense_variant 0.21 pyrazinamide
clpC1 4039577 c.1128T>C synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
clpC1 4039586 c.1119G>C synonymous_variant 0.2 pyrazinamide
clpC1 4039610 c.1095G>C synonymous_variant 0.18 pyrazinamide
clpC1 4039616 c.1089G>C synonymous_variant 0.16 pyrazinamide
clpC1 4039622 c.1083C>G synonymous_variant 0.16 pyrazinamide
clpC1 4039904 c.801A>G synonymous_variant 0.15 pyrazinamide
clpC1 4039928 c.775_777delAGCinsTCG synonymous_variant 0.19 pyrazinamide
clpC1 4039931 c.774T>C synonymous_variant 0.19 pyrazinamide
clpC1 4039946 c.759A>T synonymous_variant 0.23 pyrazinamide
clpC1 4039952 c.753T>C synonymous_variant 0.21 pyrazinamide
clpC1 4039958 c.747G>C synonymous_variant 0.22 pyrazinamide
clpC1 4039979 c.726C>G synonymous_variant 0.17 pyrazinamide
clpC1 4039996 p.Glu237Gln missense_variant 0.17 pyrazinamide
clpC1 4040021 c.684A>C synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
clpC1 4040024 c.681A>G synonymous_variant 0.21 pyrazinamide
clpC1 4040033 c.672G>C synonymous_variant 0.2 pyrazinamide
clpC1 4040036 c.669C>G synonymous_variant 0.19 pyrazinamide
clpC1 4040090 c.613_615delTCTinsAGC synonymous_variant 0.2 pyrazinamide
clpC1 4040093 c.612C>G synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
clpC1 4040105 c.600C>G synonymous_variant 0.2 pyrazinamide
clpC1 4040147 c.558A>G synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
clpC1 4040153 c.552A>G synonymous_variant 0.18 pyrazinamide
clpC1 4040162 c.543G>C synonymous_variant 0.16 pyrazinamide Not assoc w R - Interim
clpC1 4040171 c.534C>G synonymous_variant 0.15 pyrazinamide
clpC1 4040201 c.504C>G synonymous_variant 0.17 pyrazinamide
clpC1 4040207 c.498T>C synonymous_variant 0.14 pyrazinamide
clpC1 4040354 c.351A>G synonymous_variant 0.15 pyrazinamide
clpC1 4040363 c.342A>C synonymous_variant 0.17 pyrazinamide
clpC1 4040369 c.336C>G synonymous_variant 0.16 pyrazinamide
clpC1 4040380 c.325T>C synonymous_variant 0.15 pyrazinamide
clpC1 4040381 c.324T>C synonymous_variant 0.15 pyrazinamide
clpC1 4040387 c.318A>G synonymous_variant 0.16 pyrazinamide
clpC1 4040393 c.312G>C synonymous_variant 0.15 pyrazinamide Not assoc w R - Interim
clpC1 4040411 c.294T>C synonymous_variant 0.15 pyrazinamide Not assoc w R - Interim
clpC1 4040423 c.282A>G synonymous_variant 0.16 pyrazinamide Not assoc w R - Interim
clpC1 4040426 c.279T>C synonymous_variant 0.18 pyrazinamide
clpC1 4040431 c.274T>C synonymous_variant 0.18 pyrazinamide
clpC1 4040441 c.264C>G synonymous_variant 0.17 pyrazinamide
clpC1 4040444 c.261C>G synonymous_variant 0.15 pyrazinamide
clpC1 4040450 c.255A>G synonymous_variant 0.16 pyrazinamide Not assoc w R - Interim
glpK 4138547 c.1209C>T synonymous_variant 0.13 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
embC 4240578 p.Ala239Val missense_variant 0.16 ethambutol
embC 4240582 c.720C>G synonymous_variant 0.15 ethambutol
embC 4240585 c.723C>G synonymous_variant 0.15 ethambutol
embC 4240591 c.729C>G synonymous_variant 0.17 ethambutol
embC 4240594 c.732C>G synonymous_variant 0.18 ethambutol
embC 4240600 c.738G>C synonymous_variant 0.17 ethambutol
embC 4240632 p.Met257Thr missense_variant 0.19 ethambutol
embC 4240642 c.780G>C synonymous_variant 0.17 ethambutol
embC 4240654 c.792C>T synonymous_variant 0.17 ethambutol
embC 4240657 c.795G>C synonymous_variant 0.17 ethambutol
embC 4240671 p.Thr270Ile missense_variant 0.18 ethambutol Not assoc w R
embC 4240678 c.816T>G synonymous_variant 0.18 ethambutol
embC 4240685 c.823_825delACCinsGG frameshift_variant&missense_variant 0.16 ethambutol
embC 4240693 c.831T>C synonymous_variant 0.17 ethambutol
embC 4240706 p.Val282Thr missense_variant 0.16 ethambutol
embC 4240726 c.864G>C synonymous_variant 0.2 ethambutol Not assoc w R - Interim
embC 4240880 p.Ala340Thr missense_variant 0.13 ethambutol Uncertain significance
embC 4240885 c.1023T>C synonymous_variant 0.14 ethambutol
embC 4240897 c.1035C>G synonymous_variant 0.17 ethambutol Not assoc w R
embC 4241104 c.1242G>A synonymous_variant 0.15 ethambutol Not assoc w R - Interim
embC 4241107 c.1245G>C synonymous_variant 0.15 ethambutol
embC 4241141 p.Ile427Val missense_variant 0.15 ethambutol Uncertain significance
embA 4244641 p.Val470Gly missense_variant 0.98 ethambutol
embA 4245197 c.1965C>T synonymous_variant 0.97 ethambutol Not assoc w R - Interim
embB 4246641 p.Ala43Glu missense_variant 1.0 ethambutol
embB 4247233 p.Asp240Glu missense_variant 1.0 ethambutol
embB 4248118 c.1605T>C synonymous_variant 0.17 ethambutol
embB 4248127 c.1614G>C synonymous_variant 0.2 ethambutol
embB 4248133 c.1620C>G synonymous_variant 0.2 ethambutol
embB 4248142 c.1629T>C synonymous_variant 0.2 ethambutol
embB 4248143 c.1630T>C synonymous_variant 0.2 ethambutol
embB 4248157 c.1644A>G synonymous_variant 0.2 ethambutol Not assoc w R - Interim
embB 4248206 c.1693_1695delAGCinsGG frameshift_variant&missense_variant 0.18 ethambutol
embB 4248220 c.1707A>G synonymous_variant 0.16 ethambutol Not assoc w R - Interim
embB 4248241 c.1728C>T synonymous_variant 0.17 ethambutol
ethA 4327035 p.Tyr147Asp missense_variant 1.0 ethionamide
ethR 4327923 p.Gln125His missense_variant 1.0 ethionamide