TB-Profiler result

Run: SRR28044634
Summary

Run ID: SRR28044634

Sample name:

Date: 2024-05-22T16:02:24.305087

Number of reads: 5545244

Percentage reads mapped: 90.23

Median coverage: 153.0

Strain: lineage3

Spoligotype:

Drug-resistance: Other

Download CSV Download TXT Download JSON
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage3 East-African-Indian RD750 1.0
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol
pyrazinamide
streptomycin rrs n.462C>T Uncertain significance Mutation from literature
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
rrs 1472307 n.462C>T non_coding_transcript_exon_variant 0.35 streptomycin Uncertain significance Mutation from literature
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 8729 c.1428T>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8730 p.Gly477Arg missense_variant 0.18 levofloxacin Uncertain significance
moxifloxacin
gyrA 8740 p.Arg480His missense_variant 0.16 levofloxacin
moxifloxacin
gyrA 8747 c.1446A>G synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8750 c.1449C>G synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8751 p.Ala484Ser missense_variant 0.16 levofloxacin
moxifloxacin
gyrA 8756 c.1455A>G synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8762 c.1461G>C synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8767 p.Arg489Lys missense_variant 0.19 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8780 p.Asp493Glu missense_variant 0.21 levofloxacin
moxifloxacin
gyrA 8786 c.1485T>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8796 p.Ile499Val missense_variant 0.22 levofloxacin
moxifloxacin
gyrA 8801 c.1500G>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8810 c.1509A>G synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8816 c.1515C>G synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8818 p.Ser506Asn missense_variant 0.21 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8828 c.1527T>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8852 c.1551T>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8858 c.1557T>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8867 c.1566A>G synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8870 c.1569G>C synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8873 c.1572A>C synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8882 c.1581G>A synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8897 c.1596T>C synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8900 c.1599G>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8903 c.1602T>C synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8912 c.1611G>A synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 8915 c.1614A>G synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9335 c.2034G>C synonymous_variant 0.16 levofloxacin
moxifloxacin
fgd1 491742 c.960T>C synonymous_variant 1.0 clofazimine Not assoc w R
pretomanid
delamanid Not assoc w R - Interim
ccsA 619555 c.-336C>G upstream_gene_variant 0.15 capreomycin
amikacin
kanamycin
ccsA 619561 c.-330G>C upstream_gene_variant 0.16 capreomycin
amikacin
kanamycin
ccsA 619570 c.-321G>C upstream_gene_variant 0.16 capreomycin
amikacin
kanamycin
ccsA 619574 c.-317G>A upstream_gene_variant 0.16 capreomycin
amikacin
kanamycin
ccsA 619579 c.-312G>C upstream_gene_variant 0.16 capreomycin
amikacin
kanamycin
ccsA 619584 c.-307A>T upstream_gene_variant 0.15 capreomycin
amikacin
kanamycin
ccsA 620346 c.456C>G synonymous_variant 0.17 capreomycin
amikacin
kanamycin
ccsA 620362 p.Ala158Thr missense_variant 0.15 capreomycin
amikacin
kanamycin
ccsA 620367 c.477T>C synonymous_variant 0.17 capreomycin
amikacin
kanamycin
ccsA 620376 c.486G>C synonymous_variant 0.15 capreomycin
amikacin
kanamycin
ccsA 620388 c.498A>G synonymous_variant 0.14 capreomycin
amikacin
kanamycin
ccsA 620389 c.499C>T synonymous_variant 0.14 capreomycin
amikacin
kanamycin
ccsA 620664 c.774C>T synonymous_variant 0.15 capreomycin
amikacin
kanamycin
ccsA 620682 c.792G>A synonymous_variant 0.19 capreomycin
amikacin
kanamycin
ccsA 620688 c.798G>C synonymous_variant 0.21 capreomycin
amikacin
kanamycin
ccsA 620710 c.820_822delGTGinsAA frameshift_variant&missense_variant 0.2 capreomycin
amikacin
kanamycin
ccsA 620718 c.828G>C synonymous_variant 0.18 capreomycin
amikacin
kanamycin
ccsA 620721 c.831G>C synonymous_variant 0.19 capreomycin
amikacin
kanamycin
ccsA 620733 c.843G>C synonymous_variant 0.14 capreomycin
amikacin
kanamycin
ccsA 620734 c.844C>A synonymous_variant 0.14 capreomycin
amikacin
kanamycin
Rv0565c 657081 c.390G>A synonymous_variant 1.0 ethionamide Not assoc w R - Interim
rpoB 759746 c.-61C>T upstream_gene_variant 1.0 rifampicin Not assoc w R
rpoB 760223 c.417T>C synonymous_variant 0.14 rifampicin
rpoB 760298 c.492G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760307 c.501T>C synonymous_variant 0.18 rifampicin
rpoB 760310 c.504G>C synonymous_variant 0.18 rifampicin
rpoB 760328 c.522G>C synonymous_variant 0.2 rifampicin
rpoB 760331 c.525G>C synonymous_variant 0.2 rifampicin
rpoB 760340 c.534G>C synonymous_variant 0.2 rifampicin
rpoB 760361 c.555T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760370 c.564C>G synonymous_variant 0.16 rifampicin
rpoB 760376 p.Asp190Glu missense_variant 0.16 rifampicin Uncertain significance
rpoB 760380 p.Thr192Leu missense_variant 0.16 rifampicin
rpoB 760406 c.600G>C synonymous_variant 0.16 rifampicin
rpoB 760412 c.606C>G synonymous_variant 0.16 rifampicin
rpoB 760934 c.1128C>T synonymous_variant 0.14 rifampicin
rpoB 760946 c.1140A>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 760982 c.1176G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760985 c.1179G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760991 c.1185G>C synonymous_variant 0.21 rifampicin
rpoB 761006 c.1200C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 761015 c.1209G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 761027 c.1221A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 761036 c.1230G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 761037 c.1231T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 761057 c.1251G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 761195 c.1389G>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 761207 c.1401C>T synonymous_variant 0.14 rifampicin
rpoB 761213 c.1407G>C synonymous_variant 0.14 rifampicin
rpoB 761249 c.1443A>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 761255 c.1449T>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 761261 c.1455G>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 761306 c.1500C>G synonymous_variant 0.15 rifampicin
rpoB 761570 c.1764T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761573 c.1767C>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 761606 c.1800C>G synonymous_variant 0.16 rifampicin
rpoB 761813 c.2007T>C synonymous_variant 0.17 rifampicin
rpoB 761815 p.Ala670Glu missense_variant 0.17 rifampicin
rpoB 761834 c.2028T>C synonymous_variant 0.26 rifampicin
rpoB 761848 p.Cys681Ser missense_variant 0.24 rifampicin
rpoB 761852 c.2046C>G synonymous_variant 0.24 rifampicin
rpoB 761858 c.2052G>C synonymous_variant 0.26 rifampicin
rpoB 761873 c.2067A>C synonymous_variant 0.27 rifampicin
rpoB 761876 c.2070C>G synonymous_variant 0.28 rifampicin
rpoB 761885 c.2079T>C synonymous_variant 0.29 rifampicin
rpoB 761906 c.2100C>G synonymous_variant 0.26 rifampicin
rpoB 761909 c.2103T>C synonymous_variant 0.25 rifampicin
rpoB 761912 c.2106T>C synonymous_variant 0.25 rifampicin
rpoB 761915 p.Asp703Glu missense_variant 0.24 rifampicin
rpoB 761916 p.Asp704Asn missense_variant 0.24 rifampicin
rpoB 761933 c.2127G>C synonymous_variant 0.23 rifampicin
rpoB 761948 c.2142G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 761954 c.2148C>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 762329 c.2523G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 762338 c.2532T>C synonymous_variant 0.2 rifampicin
rpoB 762347 c.2541T>C synonymous_variant 0.2 rifampicin
rpoB 762362 p.Glu852Asp missense_variant 0.21 rifampicin
rpoB 762369 c.2563T>C synonymous_variant 0.22 rifampicin
rpoC 762398 c.-972T>C upstream_gene_variant 0.24 rifampicin
rpoC 762401 c.-969G>C upstream_gene_variant 0.24 rifampicin
rpoB 762404 c.2598T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 762410 c.-960T>C upstream_gene_variant 0.24 rifampicin
rpoB 762416 c.2610A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 762419 c.-951C>G upstream_gene_variant 0.22 rifampicin
rpoC 762434 c.-936T>C upstream_gene_variant 0.22 rifampicin
rpoB 762434 c.2628T>G synonymous_variant 0.78 rifampicin Not assoc w R
rpoB 762449 c.2643C>A synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 762467 c.-903C>T upstream_gene_variant 0.18 rifampicin
rpoB 763031 c.3225T>C synonymous_variant 1.0 rifampicin Not assoc w R
rpoB 763206 p.Ser1134Cys missense_variant 0.13 rifampicin
rpoC 763402 c.33C>G synonymous_variant 0.17 rifampicin
rpoC 763411 c.42T>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 763414 c.45T>C synonymous_variant 0.21 rifampicin
rpoC 763441 c.72C>T synonymous_variant 0.27 rifampicin
rpoC 763444 c.75T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 763456 c.87A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 763486 c.117T>G synonymous_variant 0.27 rifampicin
rpoC 763528 c.159G>A synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 763660 c.291T>G synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 763675 c.306C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 763696 c.327T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 763702 c.333C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 763717 c.348T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 763723 c.354G>C synonymous_variant 0.16 rifampicin
rpoC 763732 c.363C>G synonymous_variant 0.15 rifampicin
rpoC 763744 c.375G>C synonymous_variant 0.14 rifampicin
rpoC 763951 c.582G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 763960 c.591T>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 763987 c.618C>T synonymous_variant 0.14 rifampicin
rpoC 763991 c.622_624delATCinsCG frameshift_variant&missense_variant 0.15 rifampicin
rpoC 763996 c.627T>C synonymous_variant 0.14 rifampicin
rpoC 764002 c.633C>G synonymous_variant 0.15 rifampicin
rpoC 764005 c.636G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764024 c.655_657delTTGinsCC frameshift_variant&missense_variant 0.21 rifampicin
rpoC 764032 p.Asp221Glu missense_variant 0.22 rifampicin
rpoC 764040 p.Ser224Thr missense_variant 0.22 rifampicin
rpoC 764044 c.675T>C synonymous_variant 0.24 rifampicin
rpoC 764059 c.690G>C synonymous_variant 0.24 rifampicin
rpoC 764083 c.714A>G synonymous_variant 0.21 rifampicin
rpoC 764098 c.729A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764101 c.732C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764102 p.Val245Ile missense_variant 0.18 rifampicin
rpoC 764112 p.Tyr248Phe missense_variant 0.24 rifampicin
rpoC 764128 c.759C>G synonymous_variant 0.24 rifampicin
rpoC 764131 c.762T>C synonymous_variant 0.24 rifampicin
rpoC 764188 c.819A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764195 p.Ser276Ile missense_variant 0.18 rifampicin
rpoC 764203 c.834G>C synonymous_variant 0.18 rifampicin
rpoC 764206 c.837T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764215 c.846A>G synonymous_variant 0.19 rifampicin
rpoC 764257 c.888G>C synonymous_variant 0.2 rifampicin
rpoC 764266 c.897T>C synonymous_variant 0.17 rifampicin
rpoC 764269 c.900G>C synonymous_variant 0.17 rifampicin
rpoC 764272 c.903G>C synonymous_variant 0.17 rifampicin
rpoC 764278 c.909A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764626 c.1257C>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 764651 p.Ser428Thr missense_variant 0.14 rifampicin
rpoC 764716 c.1347G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 764752 c.1383G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764764 c.1395T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764791 c.1422C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764809 c.1440C>T synonymous_variant 0.2 rifampicin Not assoc w R
rpoC 764815 c.1446A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764827 c.1458G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764858 c.1489T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764872 c.1503A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764878 c.1509C>G synonymous_variant 0.2 rifampicin
rpoC 764888 c.1519T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764923 c.1554A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764932 c.1563C>G synonymous_variant 0.16 rifampicin
rpoC 764941 c.1572G>A synonymous_variant 0.15 rifampicin
rpoC 764948 c.1579T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 764968 c.1599T>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 764980 c.1611C>T synonymous_variant 0.13 rifampicin
rpoC 765811 c.2442T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 765814 c.2445A>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 765826 c.2457T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 765835 c.2466C>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 765883 c.2514C>G synonymous_variant 0.21 rifampicin
rpoC 765886 c.2517C>G synonymous_variant 0.19 rifampicin
rpoC 765892 c.2523T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 765937 c.2568T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 765967 c.2598C>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 765982 c.2613C>G synonymous_variant 0.14 rifampicin
rpoC 766384 c.3015A>G synonymous_variant 0.15 rifampicin
rpoC 766426 c.3057C>T synonymous_variant 0.15 rifampicin
rpoC 766447 c.3078T>C synonymous_variant 0.17 rifampicin
rpoC 766462 c.3093G>T synonymous_variant 0.16 rifampicin
rpoC 766483 c.3114G>C synonymous_variant 0.19 rifampicin
rpoC 766484 c.3115_3117delGTAinsAC frameshift_variant&missense_variant 0.19 rifampicin
rpoC 766492 c.3123T>C synonymous_variant 0.19 rifampicin
rpoC 766522 c.3153C>G synonymous_variant 0.2 rifampicin
rpoC 766528 c.3159T>C synonymous_variant 0.19 rifampicin
rpoC 766531 c.3162G>C synonymous_variant 0.19 rifampicin
rpoC 766540 p.Asp1057Glu missense_variant 0.18 rifampicin
rpoC 766549 c.3180G>C synonymous_variant 0.18 rifampicin
rpoC 766573 c.3204T>C synonymous_variant 0.16 rifampicin
rpoC 766582 c.3213C>G synonymous_variant 0.15 rifampicin
rpoC 766583 c.3214_3216delGGTinsAC frameshift_variant&missense_variant 0.15 rifampicin
rpoC 766594 c.3225G>C synonymous_variant 0.14 rifampicin
rpoC 766597 c.3228C>G synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 766607 p.Ile1080Leu missense_variant 0.16 rifampicin
rpoC 766630 c.3261G>C synonymous_variant 0.17 rifampicin
rpoC 766645 c.3276A>G synonymous_variant 0.19 rifampicin
rpoC 766651 c.3282T>C synonymous_variant 0.2 rifampicin
rpoC 766657 c.3288A>G synonymous_variant 0.2 rifampicin
rpoC 766672 c.3303T>C synonymous_variant 0.18 rifampicin
rpoC 766673 p.Gly1102Asn missense_variant 0.17 rifampicin
rpoC 766738 c.3369G>C synonymous_variant 0.26 rifampicin
rpoC 766765 c.3396A>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 766774 c.3405T>C synonymous_variant 0.3 rifampicin
rpoC 766777 c.3408C>T synonymous_variant 0.29 rifampicin
rpoC 766801 c.3432C>G synonymous_variant 0.29 rifampicin
rpoC 766804 c.3435A>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 766861 c.3492G>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 766864 c.3495G>C synonymous_variant 0.3 rifampicin
rpoC 766894 c.3525T>C synonymous_variant 0.25 rifampicin
rpoC 766895 c.3526T>C synonymous_variant 0.26 rifampicin
rpoC 766900 c.3531T>C synonymous_variant 0.26 rifampicin
rpoC 766903 c.3534C>T synonymous_variant 0.27 rifampicin
rpoC 766933 c.3564A>G synonymous_variant 0.24 rifampicin
rpoC 766945 c.3576A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 766963 c.3594T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 766972 c.3603G>C synonymous_variant 0.19 rifampicin
rpoC 766996 c.3627C>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 767009 c.3640_3642delTCGinsAC frameshift_variant&missense_variant 0.14 rifampicin
mmpL5 775639 p.Ile948Val missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
mmpL5 776100 p.Thr794Ile missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781700 c.141G>C synonymous_variant 0.17 streptomycin
rpsL 781703 c.144G>T synonymous_variant 0.16 streptomycin
rpsL 781715 c.156T>C synonymous_variant 0.19 streptomycin
rpsL 781728 c.169T>C synonymous_variant 0.19 streptomycin
rpsL 781736 c.177T>C synonymous_variant 0.17 streptomycin
rpsL 781742 c.183C>T synonymous_variant 0.18 streptomycin
rpsL 781748 c.189C>G synonymous_variant 0.18 streptomycin
rpsL 781754 c.195G>C synonymous_variant 0.19 streptomycin
rpsL 781760 c.201T>C synonymous_variant 0.19 streptomycin
rpsL 781772 c.213C>A synonymous_variant 0.19 streptomycin
rpsL 781808 c.249C>T synonymous_variant 0.22 streptomycin
rpsL 781811 c.252C>T synonymous_variant 0.22 streptomycin
rpsL 781832 c.273T>C synonymous_variant 0.26 streptomycin
rpsL 781838 c.279G>C synonymous_variant 0.24 streptomycin
rpsL 781841 c.282C>G synonymous_variant 0.25 streptomycin
rpsL 781865 c.306G>C synonymous_variant 0.2 streptomycin
rpsL 781868 c.309T>C synonymous_variant 0.19 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.19 streptomycin
rpsL 781877 c.318T>C synonymous_variant 0.19 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.16 streptomycin
rpsL 781898 c.339A>T synonymous_variant 0.16 streptomycin
rpsL 781916 c.357T>C synonymous_variant 0.18 streptomycin
rpsL 781929 p.Gly124Ser missense_variant 0.2 streptomycin Uncertain significance
rplC 800612 c.-197A>G upstream_gene_variant 0.18 linezolid
rplC 800618 c.-191T>C upstream_gene_variant 0.18 linezolid
rplC 800648 c.-161A>T upstream_gene_variant 0.21 linezolid
rplC 800654 c.-155T>C upstream_gene_variant 0.2 linezolid
rplC 800693 c.-116A>G upstream_gene_variant 0.23 linezolid
rplC 800703 c.-106T>C upstream_gene_variant 0.22 linezolid
rplC 800715 c.-94A>C upstream_gene_variant 0.2 linezolid
rplC 800720 c.-89T>C upstream_gene_variant 0.19 linezolid
rplC 800723 c.-86C>G upstream_gene_variant 0.19 linezolid
rplC 800747 c.-62C>G upstream_gene_variant 0.16 linezolid
rplC 800771 c.-38C>T upstream_gene_variant 0.15 linezolid
Rv1129c 1254562 c.-28T>C upstream_gene_variant 1.0 moxifloxacin Not assoc w R
levofloxacin Not assoc w R
rifampicin Not assoc w R
isoniazid Not assoc w R
fbiC 1304138 p.Ala403Val missense_variant 0.99 clofazimine
pretomanid
delamanid
fbiC 1304640 c.1710A>C synonymous_variant 0.15 clofazimine
pretomanid
delamanid
fbiC 1304646 c.1716T>C synonymous_variant 0.15 clofazimine
pretomanid
delamanid
fbiC 1304691 c.1761G>C synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1304694 c.1764A>C synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1304703 c.1773C>G synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1304711 p.Ala594Glu missense_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1304715 c.1785G>C synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1304724 c.1794A>G synonymous_variant 0.17 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1304727 c.1797A>G synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1304742 c.1812T>G synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1304748 c.1818T>C synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1304757 c.1827A>G synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1304778 c.1848T>C synonymous_variant 0.15 clofazimine
pretomanid
delamanid
fbiC 1304784 c.1854T>C synonymous_variant 0.15 clofazimine
pretomanid
delamanid
fbiC 1304787 c.1857T>G synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1304808 c.1878C>G synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1304811 c.1881C>G synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1304817 c.1887T>C synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1304829 c.1899T>C synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1304832 c.1902C>T synonymous_variant 0.23 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1304853 c.1923C>T synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1304856 c.1926C>G synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1304869 c.1939C>T synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1304875 p.Ile649Val missense_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1304891 p.Ile654Thr missense_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1304893 p.Gly655Ser missense_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1304898 c.1968G>T synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1304907 c.1977C>G synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1304910 c.1980G>C synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1304916 c.1986T>C synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1304928 c.1998T>C synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1304937 c.2007G>C synonymous_variant 0.15 clofazimine
pretomanid
delamanid
fbiC 1304940 c.2010A>G synonymous_variant 0.16 clofazimine
pretomanid
delamanid
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471969 n.124T>C non_coding_transcript_exon_variant 0.17 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471970 n.125G>A non_coding_transcript_exon_variant 0.16 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472053 n.211_212delGC non_coding_transcript_exon_variant 0.15 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472061 n.216A>T non_coding_transcript_exon_variant 0.15 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472075 n.230A>G non_coding_transcript_exon_variant 0.17 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.15 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472969 n.1124A>G non_coding_transcript_exon_variant 0.23 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472970 n.1125C>G non_coding_transcript_exon_variant 0.23 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472977 n.1132G>C non_coding_transcript_exon_variant 0.25 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472978 n.1133T>C non_coding_transcript_exon_variant 0.25 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473105 n.1260G>A non_coding_transcript_exon_variant 0.22 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473123 n.1278delAinsTT non_coding_transcript_exon_variant 0.18 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.22 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.2 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473290 n.1445C>T non_coding_transcript_exon_variant 0.17 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrl 1473756 n.99G>A non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1473758 n.101G>T non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid
rrl 1473806 n.149C>T non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473943 n.286G>T non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid
rrl 1473945 n.288T>A non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid
rrl 1473946 n.289A>T non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid
rrl 1473986 n.329T>C non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1473987 n.330G>A non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1473995 n.338G>T non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1474001 n.344C>T non_coding_transcript_exon_variant 0.26 capreomycin Not assoc w R
linezolid Not assoc w R
rrl 1474009 n.352A>G non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1474012 n.355C>T non_coding_transcript_exon_variant 0.28 capreomycin
linezolid
rrl 1474040 n.383G>A non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1474093 n.436G>T non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1474099 n.442G>A non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1474103 n.446A>T non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1474140 n.483C>T non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474181 n.524C>T non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474310 n.653T>G non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
rrl 1474356 n.699T>C non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid
rrl 1474362 n.705A>G non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474376 n.719T>C non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1474639 n.982G>A non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474823 n.1166C>T non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1474831 n.1174A>G non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid
rrl 1474904 n.1247G>A non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1475061 n.1404C>T non_coding_transcript_exon_variant 0.14 capreomycin Uncertain significance
linezolid
rrl 1475088 n.1431A>T non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1475199 n.1542G>A non_coding_transcript_exon_variant 0.29 capreomycin
linezolid
rrl 1475206 n.1549C>T non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid
rrl 1475209 n.1552G>C non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid
rrl 1475213 n.1556C>T non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid
rrl 1475249 n.1592T>C non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475252 n.1595C>T non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1475266 n.1609T>C non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475267 n.1610G>A non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1475275 n.1618C>T non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1475276 n.1619T>C non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1475291 n.1634A>C non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475483 n.1826C>T non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475505 n.1848G>A non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475599 n.1942A>G non_coding_transcript_exon_variant 0.34 capreomycin
linezolid Uncertain significance
rrl 1475608 n.1951T>C non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid
rrl 1475642 n.1985T>C non_coding_transcript_exon_variant 0.32 capreomycin
linezolid
rrl 1475657 n.2000A>G non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1475659 n.2002G>T non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1475761 n.2104_2106delCGCinsGT non_coding_transcript_exon_variant 0.4 capreomycin
linezolid
rrl 1475765 n.2111delG non_coding_transcript_exon_variant 0.4 capreomycin
linezolid
rrl 1475881 n.2224T>C non_coding_transcript_exon_variant 0.35 capreomycin
linezolid
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.2 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476583 n.2926G>A non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.25 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476594 n.2937C>T non_coding_transcript_exon_variant 0.25 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476597 n.2940G>A non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid
rrl 1476603 n.2946G>A non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476608 n.2951C>G non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476689 n.3032A>T non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
rrl 1476690 n.3033C>T non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid
rrl 1476693 n.3036G>A non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
rrl 1476695 n.3038T>A non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1476716 n.3059A>C non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid
rrl 1476726 n.3069A>G non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1476732 n.3075T>C non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
rrl 1476755 n.3098G>A non_coding_transcript_exon_variant 0.14 capreomycin
linezolid
rpsA 1833568 c.27G>C synonymous_variant 0.14 pyrazinamide Not assoc w R - Interim
rpsA 1833589 c.48A>T synonymous_variant 0.21 pyrazinamide
rpsA 1833595 c.54T>C synonymous_variant 0.2 pyrazinamide
rpsA 1833661 c.120A>G synonymous_variant 0.21 pyrazinamide
rpsA 1833667 c.126C>G synonymous_variant 0.21 pyrazinamide
rpsA 1833721 c.180A>G synonymous_variant 0.26 pyrazinamide
rpsA 1833727 c.186G>C synonymous_variant 0.27 pyrazinamide
rpsA 1833742 c.201A>G synonymous_variant 0.27 pyrazinamide
rpsA 1833745 c.204G>C synonymous_variant 0.27 pyrazinamide
rpsA 1833748 c.207C>G synonymous_variant 0.27 pyrazinamide
rpsA 1833787 c.246C>G synonymous_variant 0.29 pyrazinamide
rpsA 1833790 c.249T>C synonymous_variant 0.3 pyrazinamide
rpsA 1833802 c.261A>G synonymous_variant 0.3 pyrazinamide
rpsA 1833811 c.270G>T synonymous_variant 0.32 pyrazinamide
rpsA 1833838 c.297G>C synonymous_variant 0.31 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.31 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.31 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.29 pyrazinamide
rpsA 1833874 c.333T>C synonymous_variant 0.29 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.26 pyrazinamide
rpsA 1833940 c.399C>G synonymous_variant 0.26 pyrazinamide
rpsA 1833971 c.430C>T synonymous_variant 0.22 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.22 pyrazinamide
rpsA 1833991 c.450C>G synonymous_variant 0.23 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.24 pyrazinamide
rpsA 1834021 c.480C>T synonymous_variant 0.21 pyrazinamide
rpsA 1834030 c.489C>G synonymous_variant 0.18 pyrazinamide
rpsA 1834169 p.Thr210Ala missense_variant 0.16 pyrazinamide Uncertain significance
rpsA 1834177 c.636A>C synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
rpsA 1834189 c.648G>C synonymous_variant 0.19 pyrazinamide
rpsA 1834195 c.654G>C synonymous_variant 0.19 pyrazinamide
rpsA 1834210 c.669C>T synonymous_variant 0.18 pyrazinamide
rpsA 1834222 c.681T>C synonymous_variant 0.18 pyrazinamide
rpsA 1834231 c.690T>C synonymous_variant 0.18 pyrazinamide
rpsA 1834234 c.693G>C synonymous_variant 0.16 pyrazinamide
rpsA 1834249 c.708T>C synonymous_variant 0.15 pyrazinamide
rpsA 1834261 c.720A>G synonymous_variant 0.14 pyrazinamide Not assoc w R - Interim
rpsA 1834262 p.Ser241Arg missense_variant 0.14 pyrazinamide
rpsA 1834303 c.762T>C synonymous_variant 0.17 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.18 pyrazinamide
rpsA 1834513 c.972C>G synonymous_variant 0.15 pyrazinamide
rpsA 1834540 c.999G>C synonymous_variant 0.15 pyrazinamide
rpsA 1834546 c.1005T>C synonymous_variant 0.16 pyrazinamide
rpsA 1834606 c.1065C>G synonymous_variant 0.19 pyrazinamide
rpsA 1834609 c.1068T>A synonymous_variant 0.18 pyrazinamide
rpsA 1834633 c.1092A>G synonymous_variant 0.18 pyrazinamide
rpsA 1834690 c.1149T>C synonymous_variant 0.16 pyrazinamide
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
bacA 2064979 c.-251C>T upstream_gene_variant 0.14 streptomycin
kanamycin
capreomycin
amikacin
katG 2154724 p.Arg463Leu missense_variant 0.99 isoniazid Not assoc w R
PPE35 2167926 p.Leu896Ser missense_variant 1.0 pyrazinamide Not assoc w R
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
pncA 2289047 c.195C>T synonymous_variant 0.99 pyrazinamide Not assoc w R
pncA 2289365 c.-125delC upstream_gene_variant 1.0 pyrazinamide
kasA 2519116 c.1002C>G synonymous_variant 0.15 isoniazid
kasA 2519122 c.1008G>C synonymous_variant 0.14 isoniazid
kasA 2519137 c.1023T>G synonymous_variant 0.17 isoniazid
kasA 2519158 c.1044C>T synonymous_variant 0.17 isoniazid
kasA 2519167 c.1053T>G synonymous_variant 0.18 isoniazid
kasA 2519173 c.1059C>G synonymous_variant 0.17 isoniazid
kasA 2519206 c.1092C>T synonymous_variant 0.14 isoniazid
ahpC 2726105 c.-88G>A upstream_gene_variant 1.0 isoniazid Not assoc w R
Rv2477c 2782498 c.1545C>T synonymous_variant 0.99 ethambutol Not assoc w R
moxifloxacin Not assoc w R
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R
kanamycin Not assoc w R
rifampicin Not assoc w R
amikacin Not assoc w R
thyX 3067472 c.474C>G synonymous_variant 0.99 para-aminosalicylic_acid
thyA 3073860 c.612C>G synonymous_variant 0.15 para-aminosalicylic_acid
thyA 3073863 c.609T>C synonymous_variant 0.17 para-aminosalicylic_acid
thyA 3073872 c.598_600delATCinsGG frameshift_variant&missense_variant 0.17 para-aminosalicylic_acid
thyA 3073892 c.580T>C synonymous_variant 0.2 para-aminosalicylic_acid
thyA 3073917 c.555C>G synonymous_variant 0.23 para-aminosalicylic_acid
thyA 3073920 c.552C>G synonymous_variant 0.24 para-aminosalicylic_acid
thyA 3073925 c.547T>C synonymous_variant 0.25 para-aminosalicylic_acid
thyA 3073929 c.543T>C synonymous_variant 0.26 para-aminosalicylic_acid
thyA 3073953 c.519T>C synonymous_variant 0.25 para-aminosalicylic_acid
thyA 3073956 c.516G>C synonymous_variant 0.23 para-aminosalicylic_acid
thyA 3073959 c.513T>C synonymous_variant 0.23 para-aminosalicylic_acid
thyA 3073977 c.495A>G synonymous_variant 0.21 para-aminosalicylic_acid
thyA 3073989 c.483T>C synonymous_variant 0.18 para-aminosalicylic_acid
thyA 3074004 c.468T>C synonymous_variant 0.16 para-aminosalicylic_acid
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
mtrB 3625065 p.Met517Leu missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
mtrA 3627242 c.108C>T synonymous_variant 0.14 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627254 c.-641C>T upstream_gene_variant 0.16 bedaquiline
rifampicin
mtrB 3627263 c.-650C>T upstream_gene_variant 0.15 bedaquiline
rifampicin
mtrB 3627266 c.-653A>G upstream_gene_variant 0.16 bedaquiline
rifampicin
mtrB 3627272 c.-659G>T upstream_gene_variant 0.15 bedaquiline
rifampicin
mtrB 3627275 c.-662G>T upstream_gene_variant 0.16 bedaquiline
rifampicin
mtrB 3627296 c.-683T>C upstream_gene_variant 0.15 bedaquiline
rifampicin
mtrA 3627299 c.51G>A synonymous_variant 0.14 bedaquiline
rifampicin Not assoc w R - Interim
alr 3841473 c.-53G>A upstream_gene_variant 0.99 cycloserine
rpoA 3877553 p.Glu319Gln missense_variant 0.2 rifampicin
rpoA 3877571 p.Pro313Ala missense_variant 0.21 rifampicin
rpoA 3877587 c.921A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoA 3877613 p.Ile299Val missense_variant 0.29 rifampicin
rpoA 3877656 c.852T>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoA 3877668 c.840A>G synonymous_variant 0.27 rifampicin
rpoA 3877679 p.Ala277Ser missense_variant 0.27 rifampicin
rpoA 3877686 c.822A>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoA 3877692 c.816G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoA 3877704 c.804G>C synonymous_variant 0.26 rifampicin
rpoA 3877737 c.771G>C synonymous_variant 0.23 rifampicin
rpoA 3877743 c.765T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoA 3877764 c.744C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3877770 c.738A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoA 3877776 c.732T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoA 3877782 c.726T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3877791 c.717C>G synonymous_variant 0.22 rifampicin
rpoA 3877818 c.690A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoA 3877839 c.669G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoA 3877848 c.660C>T synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoA 3877857 c.651G>A synonymous_variant 0.24 rifampicin
rpoA 3877866 c.642G>C synonymous_variant 0.25 rifampicin
rpoA 3877875 c.633T>G synonymous_variant 0.26 rifampicin
rpoA 3877878 c.630G>C synonymous_variant 0.25 rifampicin
rpoA 3877890 c.618C>T synonymous_variant 0.28 rifampicin
rpoA 3877896 c.612G>C synonymous_variant 0.28 rifampicin
rpoA 3877900 p.Ser203Asn missense_variant 0.28 rifampicin
rpoA 3877905 c.603A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoA 3877909 p.Asn200Ser missense_variant 0.27 rifampicin
rpoA 3877920 c.588G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoA 3877923 c.585C>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoA 3877926 c.582G>C synonymous_variant 0.25 rifampicin
rpoA 3877962 c.546G>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoA 3878247 c.261G>C synonymous_variant 0.17 rifampicin
rpoA 3878271 c.237T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoA 3878284 p.Glu75Ala missense_variant 0.27 rifampicin
rpoA 3878292 c.216T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoA 3878298 c.210A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoA 3878304 c.204G>C synonymous_variant 0.29 rifampicin
rpoA 3878313 c.195G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoA 3878322 c.186A>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoA 3878331 c.177A>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoA 3878334 c.174T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoA 3878337 c.171T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoA 3878346 c.162T>C synonymous_variant 0.28 rifampicin
rpoA 3878364 c.144A>T synonymous_variant 0.27 rifampicin
rpoA 3878367 c.141C>G synonymous_variant 0.26 rifampicin
rpoA 3878376 c.132G>C synonymous_variant 0.28 rifampicin
rpoA 3878385 c.123C>G synonymous_variant 0.29 rifampicin
rpoA 3878388 c.120C>G synonymous_variant 0.28 rifampicin
rpoA 3878391 c.117T>C synonymous_variant 0.27 rifampicin
rpoA 3878415 c.93C>T synonymous_variant 0.23 rifampicin
rpoA 3878424 c.84G>C synonymous_variant 0.21 rifampicin
rpoA 3878436 c.72A>G synonymous_variant 0.17 rifampicin
rpoA 3878442 c.66G>C synonymous_variant 0.14 rifampicin
rpoA 3878785 c.-278T>G upstream_gene_variant 0.17 rifampicin
rpoA 3878788 c.-281G>C upstream_gene_variant 0.18 rifampicin Uncertain significance
rpoA 3878806 c.-299C>G upstream_gene_variant 0.24 rifampicin
rpoA 3878809 c.-302T>C upstream_gene_variant 0.24 rifampicin
rpoA 3878824 c.-317G>C upstream_gene_variant 0.25 rifampicin
rpoA 3878833 c.-326C>G upstream_gene_variant 0.23 rifampicin
rpoA 3878836 c.-331_-329delAAGinsTCC upstream_gene_variant 0.23 rifampicin
rpoA 3878853 c.-346G>A upstream_gene_variant 0.27 rifampicin
rpoA 3878878 c.-371T>C upstream_gene_variant 0.27 rifampicin Uncertain significance
rpoA 3878909 c.-402A>G upstream_gene_variant 0.28 rifampicin
rpoA 3878914 c.-407T>C upstream_gene_variant 0.28 rifampicin Uncertain significance
rpoA 3878917 c.-410G>A upstream_gene_variant 0.29 rifampicin Uncertain significance
rpoA 3878938 c.-431T>C upstream_gene_variant 0.28 rifampicin
rpoA 3878947 c.-440G>C upstream_gene_variant 0.26 rifampicin Uncertain significance
rpoA 3878962 c.-455G>A upstream_gene_variant 0.3 rifampicin Uncertain significance
rpoA 3878968 c.-461T>C upstream_gene_variant 0.27 rifampicin Uncertain significance
rpoA 3878976 c.-469A>G upstream_gene_variant 0.26 rifampicin Uncertain significance
rpoA 3878986 c.-479G>C upstream_gene_variant 0.24 rifampicin
rpoA 3878998 c.-491C>G upstream_gene_variant 0.25 rifampicin Uncertain significance
rpoA 3879005 c.-499_-498delAAinsCG upstream_gene_variant 0.22 rifampicin
rpoA 3879013 c.-506A>G upstream_gene_variant 0.24 rifampicin
rpoA 3879079 c.-572A>G upstream_gene_variant 0.28 rifampicin
rpoA 3879088 c.-581A>C upstream_gene_variant 0.27 rifampicin
rpoA 3879094 c.-587T>C upstream_gene_variant 0.28 rifampicin
rpoA 3879121 c.-614T>G upstream_gene_variant 0.25 rifampicin
rpoA 3879127 c.-620T>C upstream_gene_variant 0.26 rifampicin
rpoA 3879154 c.-647T>C upstream_gene_variant 0.25 rifampicin
rpoA 3879160 c.-653A>G upstream_gene_variant 0.23 rifampicin
rpoA 3879178 c.-671T>C upstream_gene_variant 0.2 rifampicin
rpoA 3879190 c.-683C>G upstream_gene_variant 0.19 rifampicin
clpC1 4038755 c.1950G>T synonymous_variant 0.14 pyrazinamide
clpC1 4038764 c.1941C>G synonymous_variant 0.15 pyrazinamide
clpC1 4038770 c.1935C>T synonymous_variant 0.15 pyrazinamide
clpC1 4038773 c.1932T>C synonymous_variant 0.16 pyrazinamide
clpC1 4038782 c.1923G>C synonymous_variant 0.17 pyrazinamide
clpC1 4038812 c.1893T>C synonymous_variant 0.18 pyrazinamide
clpC1 4038845 c.1860G>C synonymous_variant 0.18 pyrazinamide
clpC1 4038860 c.1845G>C synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
clpC1 4038878 c.1827A>G synonymous_variant 0.18 pyrazinamide Not assoc w R - Interim
clpC1 4038908 c.1797C>G synonymous_variant 0.16 pyrazinamide
clpC1 4038923 c.1782A>G synonymous_variant 0.14 pyrazinamide
clpC1 4039286 c.1419T>C synonymous_variant 0.15 pyrazinamide
clpC1 4039295 c.1410A>C synonymous_variant 0.15 pyrazinamide
clpC1 4039298 c.1407T>C synonymous_variant 0.16 pyrazinamide
clpC1 4039319 c.1386T>C synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
clpC1 4039322 c.1383T>C synonymous_variant 0.17 pyrazinamide
clpC1 4039328 c.1377A>C synonymous_variant 0.17 pyrazinamide
clpC1 4039331 c.1374C>G synonymous_variant 0.17 pyrazinamide
clpC1 4039337 p.Thr456Gln missense_variant 0.17 pyrazinamide
clpC1 4039349 c.1356C>T synonymous_variant 0.21 pyrazinamide
clpC1 4039352 c.1353C>G synonymous_variant 0.21 pyrazinamide
clpC1 4039364 c.1341C>G synonymous_variant 0.21 pyrazinamide
clpC1 4039391 c.1314T>G synonymous_variant 0.15 pyrazinamide
clpC1 4039928 c.775_777delAGCinsTCG synonymous_variant 0.16 pyrazinamide
clpC1 4039931 c.774T>C synonymous_variant 0.17 pyrazinamide
clpC1 4039937 c.768G>C synonymous_variant 0.16 pyrazinamide
clpC1 4039946 c.759A>C synonymous_variant 0.15 pyrazinamide
clpC1 4039952 c.753T>C synonymous_variant 0.15 pyrazinamide
panD 4044872 c.-591C>T upstream_gene_variant 1.0 pyrazinamide
glpK 4138622 c.1134C>T synonymous_variant 1.0 ethambutol Not assoc w R
moxifloxacin Not assoc w R
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R
rifampicin Not assoc w R
isoniazid Not assoc w R
embC 4240693 c.831T>G synonymous_variant 0.16 ethambutol
embC 4240699 c.837C>G synonymous_variant 0.17 ethambutol Not assoc w R - Interim
embC 4240726 c.864G>C synonymous_variant 0.16 ethambutol Not assoc w R - Interim
embC 4240780 c.918T>C synonymous_variant 0.14 ethambutol
embC 4240789 c.927T>C synonymous_variant 0.14 ethambutol
embC 4240819 c.957A>G synonymous_variant 0.14 ethambutol
embC 4242075 p.Arg738Gln missense_variant 1.0 ethambutol Not assoc w R
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
embA 4245149 c.1917C>G synonymous_variant 0.15 ethambutol
embA 4245153 p.Ile641Val missense_variant 0.16 ethambutol
embA 4245170 c.1938G>T synonymous_variant 0.2 ethambutol
embA 4245182 c.1950T>C synonymous_variant 0.22 ethambutol
embA 4245189 c.1957C>T synonymous_variant 0.22 ethambutol
embA 4245198 p.Leu656Ile missense_variant 0.21 ethambutol
embA 4245207 c.1975T>C synonymous_variant 0.21 ethambutol
embA 4245215 c.1983A>C synonymous_variant 0.21 ethambutol
embA 4245222 c.1990_1992delTATinsCG frameshift_variant&missense_variant 0.19 ethambutol Uncertain significance
embB 4248007 c.1494C>G synonymous_variant 0.15 ethambutol
embB 4248035 p.Val508Ile missense_variant 0.13 ethambutol
embB 4248052 c.1539G>A synonymous_variant 0.15 ethambutol
embB 4248070 c.1557T>C synonymous_variant 0.15 ethambutol
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 capreomycin
amikacin
kanamycin
gid 4407588 c.615A>G synonymous_variant 1.0 streptomycin Not assoc w R