TB-Profiler result

Run: ERR9786639
Summary

Run ID: ERR9786639

Sample name:

Date: 2025-09-15T15:21:00.585387

Number of reads: 1623198

Percentage reads mapped: 88.62

Median coverage: 77.5

Strain: lineage4.8

Spoligotype:

Drug-resistance: Sensitive

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage4 Euro-American None 100.0
lineage4.8 Euro-American (mainly T) RD219 100.0
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
dnaA 371 p.Pro124Leu missense_variant 1.0 isoniazid Not assoc w R
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7592 c.291G>C synonymous_variant 0.12 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7595 c.294C>G synonymous_variant 0.13 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 7607 c.306C>G synonymous_variant 0.13 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7706 c.405C>G synonymous_variant 0.13 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 7715 c.414G>C synonymous_variant 0.13 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 7725 c.424C>T synonymous_variant 0.14 levofloxacin Not assoc w R - Interim
moxifloxacin Uncertain significance
gyrA 7797 c.496_498delCTAinsTTG synonymous_variant 0.14 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 7802 c.501C>G synonymous_variant 0.13 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 7814 c.513C>G synonymous_variant 0.14 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
rpoB 761165 c.1359G>A synonymous_variant 0.13 rifampicin Uncertain significance
rpoB 761168 c.1362C>G synonymous_variant 0.13 rifampicin Uncertain significance
rpoB 761171 c.1365C>T synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 761195 c.1389G>C synonymous_variant 0.12 rifampicin Not assoc w R - Interim
rpoB 761204 c.1398C>T synonymous_variant 0.13 rifampicin Uncertain significance
rpoB 761207 c.1401C>T synonymous_variant 0.13 rifampicin Uncertain significance
rpoB 761222 c.1416G>C synonymous_variant 0.13 rifampicin Uncertain significance
rpoB 761510 c.1704T>C synonymous_variant 0.15 rifampicin Uncertain significance
rpoB 761516 c.1710G>C synonymous_variant 0.16 rifampicin Uncertain significance
rpoB 761537 c.1731C>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 762053 c.2247T>C synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoB 762062 c.2256T>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 762083 c.2277T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 762086 c.2280G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 762101 c.2295C>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 762114 p.Ile770Val missense_variant 0.16 rifampicin Uncertain significance
rpoB 762131 c.2325C>G synonymous_variant 0.17 rifampicin Uncertain significance
rpoB 762134 c.2328C>T synonymous_variant 0.17 rifampicin Uncertain significance
rpoB 762140 c.2334G>C synonymous_variant 0.17 rifampicin Uncertain significance
rpoB 762143 c.2337T>C synonymous_variant 0.17 rifampicin Uncertain significance
rpoB 762149 c.2343G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 762158 c.2352G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 762167 c.2361T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 762176 c.2370T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 762185 c.2379G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 762212 c.2406G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 762236 c.2430G>C synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoB 762257 c.2451C>G synonymous_variant 0.12 rifampicin Uncertain significance
rpoB 762266 c.2460T>C synonymous_variant 0.13 rifampicin Uncertain significance
rpoB 762857 c.3051C>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 762860 c.3054G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 762917 c.3111C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 762920 c.3114C>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 762926 c.-444C>G upstream_gene_variant 0.17 rifampicin Uncertain significance
rpoB 762929 c.3123G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 762995 c.3189G>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 763028 c.3222T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 763034 c.3228C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 763040 c.3234C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 763050 c.-320C>T upstream_gene_variant 0.15 rifampicin Uncertain significance
rpoB 763053 c.3247T>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 763058 c.-312C>G upstream_gene_variant 0.14 rifampicin Uncertain significance
rpoC 763076 c.-294C>G upstream_gene_variant 0.13 rifampicin Uncertain significance
rpoC 764140 c.771C>T synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoC 764143 c.774G>C synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoC 766585 c.3216T>C synonymous_variant 0.15 rifampicin Uncertain significance
rpoC 766607 p.Ile1080Leu missense_variant 0.17 rifampicin Uncertain significance
rpoC 766610 p.Ser1081Pro missense_variant 0.14 rifampicin Uncertain significance
rpoC 766618 c.3249G>T synonymous_variant 0.13 rifampicin Uncertain significance
rpoC 766630 c.3261G>T synonymous_variant 0.13 rifampicin Uncertain significance
rpoC 766690 c.3321G>C synonymous_variant 0.14 rifampicin Uncertain significance
rpoC 766702 c.3333G>C synonymous_variant 0.15 rifampicin Uncertain significance
rpoC 766708 c.3339A>G synonymous_variant 0.15 rifampicin Uncertain significance
rpoC 766726 c.3357T>C synonymous_variant 0.15 rifampicin Uncertain significance
rpoC 766738 c.3369G>T synonymous_variant 0.15 rifampicin Uncertain significance
rpoC 766750 c.3381C>A synonymous_variant 0.14 rifampicin Uncertain significance
rpoC 766765 c.3396A>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 766774 c.3405T>C synonymous_variant 0.16 rifampicin Uncertain significance
rpoC 766775 p.Arg1136Asn missense_variant 0.16 rifampicin Uncertain significance
rpoC 766787 p.Glu1140Gln missense_variant 0.15 rifampicin Uncertain significance
rpoC 766798 c.3429C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 766804 c.3435A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 767002 c.3633G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 767020 c.3651C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 767023 c.3654C>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 767041 c.3672G>C synonymous_variant 0.23 rifampicin Uncertain significance
rpoC 767044 c.3675G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
mmpL5 775639 p.Ile948Val missense_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
streptomycin Uncertain significance
rrs 1472286 n.441C>G non_coding_transcript_exon_variant 0.14 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
streptomycin Uncertain significance
rrs 1472287 n.442C>T non_coding_transcript_exon_variant 0.15 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
streptomycin Uncertain significance
rrs 1472292 n.447A>G non_coding_transcript_exon_variant 0.14 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
streptomycin Uncertain significance
rrs 1472298 n.453G>C non_coding_transcript_exon_variant 0.13 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
streptomycin Uncertain significance
rrs 1472311 n.466C>T non_coding_transcript_exon_variant 0.13 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
streptomycin Uncertain significance
rrs 1472314 n.469A>G non_coding_transcript_exon_variant 0.13 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
streptomycin Uncertain significance
rrs 1472315 n.470T>G non_coding_transcript_exon_variant 0.13 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
streptomycin Uncertain significance
rrs 1472327 n.482G>A non_coding_transcript_exon_variant 0.13 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
streptomycin Uncertain significance
rrs 1472328 n.483G>C non_coding_transcript_exon_variant 0.13 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
streptomycin Uncertain significance
rrs 1472431 n.586G>A non_coding_transcript_exon_variant 0.15 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
streptomycin Uncertain significance
rrs 1472438 n.593T>C non_coding_transcript_exon_variant 0.15 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
streptomycin Uncertain significance
rrs 1472446 n.601T>A non_coding_transcript_exon_variant 0.16 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
streptomycin Uncertain significance
rrs 1472452 n.607G>A non_coding_transcript_exon_variant 0.15 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
streptomycin Uncertain significance
rrs 1472464 n.619A>G non_coding_transcript_exon_variant 0.18 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
streptomycin Uncertain significance
rrs 1472489 n.644A>G non_coding_transcript_exon_variant 0.16 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
streptomycin Uncertain significance
rrs 1472498 n.653C>T non_coding_transcript_exon_variant 0.17 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
streptomycin Uncertain significance
rrs 1472683 n.838_839insTA non_coding_transcript_exon_variant 0.24 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
streptomycin Uncertain significance
rrs 1472847 n.1002G>C non_coding_transcript_exon_variant 0.17 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
streptomycin Uncertain significance
rrs 1472848 n.1003T>G non_coding_transcript_exon_variant 0.17 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
streptomycin Uncertain significance
rrs 1472849 n.1004C>G non_coding_transcript_exon_variant 0.16 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
streptomycin Uncertain significance
rrs 1472858 n.1013G>T non_coding_transcript_exon_variant 0.16 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
streptomycin Uncertain significance
rrs 1472859 n.1014G>C non_coding_transcript_exon_variant 0.16 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
streptomycin Uncertain significance
rrs 1472860 n.1015C>G non_coding_transcript_exon_variant 0.17 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
streptomycin Uncertain significance
rrs 1472973 n.1128A>T non_coding_transcript_exon_variant 0.21 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
streptomycin Uncertain significance
rrs 1473100 n.1255G>C non_coding_transcript_exon_variant 0.22 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
streptomycin Uncertain significance
rrs 1473104 n.1259C>T non_coding_transcript_exon_variant 0.21 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
streptomycin Uncertain significance
rrs 1473109 n.1264T>G non_coding_transcript_exon_variant 0.21 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
streptomycin Uncertain significance
rrs 1473111 n.1266A>T non_coding_transcript_exon_variant 0.22 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
streptomycin Uncertain significance
rrs 1473123 n.1278A>T non_coding_transcript_exon_variant 0.25 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
streptomycin Uncertain significance
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.2 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
streptomycin Uncertain significance
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.22 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
streptomycin Uncertain significance
rrs 1473276 n.1431A>G non_coding_transcript_exon_variant 0.17 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
streptomycin Uncertain significance
rrs 1473290 n.1445C>T non_coding_transcript_exon_variant 0.14 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
streptomycin Uncertain significance
rrs 1473291 n.1446_1447insT non_coding_transcript_exon_variant 0.17 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
streptomycin Uncertain significance
rrs 1473301 n.1456T>C non_coding_transcript_exon_variant 0.15 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
streptomycin Uncertain significance
rrl 1474001 n.344C>T non_coding_transcript_exon_variant 1.0 capreomycin Not assoc w R
linezolid Not assoc w R
rrl 1474083 n.426C>T non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474093 n.436G>A non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474094 n.437C>T non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474100 n.443C>T non_coding_transcript_exon_variant 0.13 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474103 n.446A>T non_coding_transcript_exon_variant 0.13 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474110 n.453A>T non_coding_transcript_exon_variant 0.12 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474140 n.483C>T non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474174 n.517A>G non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474452 n.795C>G non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474552 n.895C>T non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474632 n.975G>T non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474636 n.979A>T non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474638 n.981C>A non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474639 n.982G>C non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474640 n.983C>T non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474708 n.1052dupG non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474711 n.1054_1055insA non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474715 n.1061delA non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474753 n.1096A>G non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474760 n.1103A>G non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>A non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474830 n.1173A>T non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474831 n.1174A>T non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475031 n.1374G>T non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475061 n.1404C>T non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475062 n.1405A>G non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475120 n.1463G>T non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475202 n.1545G>C non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475209 n.1552G>A non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475213 n.1556C>T non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475291 n.1634A>C non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475315 n.1658A>T non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475505 n.1848G>A non_coding_transcript_exon_variant 0.14 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.12 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475544 n.1887A>T non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475659 n.2002G>A non_coding_transcript_exon_variant 0.14 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475753 n.2096C>G non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475762 n.2105G>T non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475763 n.2106C>T non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475764 n.2107A>C non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475765 n.2108A>G non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475775 n.2118G>T non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475916 n.2259C>T non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475975 n.2318C>T non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475977 n.2320A>G non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475995 n.2338G>A non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475997 n.2340A>G non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476032 n.2375_2378delCTCGinsTCGC non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476044 n.2387T>G non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476045 n.2388G>T non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476049 n.2392C>T non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476086 n.2429G>A non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476088 n.2431A>C non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476095 n.2438C>T non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476103 n.2446C>A non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476108 n.2451T>G non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476110 n.2453G>T non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476115 n.2458T>C non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476131 n.2474C>T non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476214 n.2557G>T non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476215 n.2558C>T non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476245 n.2588C>T non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476246 n.2589G>A non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476252 n.2595T>G non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476256 n.2599A>C non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476262 n.2605G>A non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476529 n.2872A>T non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
inhA 1674416 p.Ala72Gly missense_variant 0.19 ethionamide Uncertain significance
isoniazid Uncertain significance
inhA 1674418 c.217_219delAGCinsTCG synonymous_variant 0.2 ethionamide Uncertain significance
isoniazid Uncertain significance
inhA 1674428 p.Gly76Glu missense_variant 0.2 ethionamide Uncertain significance
isoniazid Uncertain significance
inhA 1674435 c.234G>C synonymous_variant 0.21 ethionamide Uncertain significance
isoniazid Uncertain significance
inhA 1674443 p.Ala81Val missense_variant 0.21 ethionamide Uncertain significance
isoniazid Uncertain significance
inhA 1674450 c.249G>C synonymous_variant 0.2 ethionamide Uncertain significance
isoniazid Uncertain significance
inhA 1674452 p.Ala84Glu missense_variant 0.2 ethionamide Uncertain significance
isoniazid Uncertain significance
inhA 1674471 c.270G>C synonymous_variant 0.2 ethionamide Uncertain significance
isoniazid Uncertain significance
inhA 1674480 c.279T>C synonymous_variant 0.18 ethionamide Uncertain significance
isoniazid Uncertain significance
inhA 1674483 c.282G>C synonymous_variant 0.18 ethionamide Uncertain significance
isoniazid Uncertain significance
inhA 1674486 c.285T>C synonymous_variant 0.18 ethionamide Uncertain significance
isoniazid Uncertain significance
inhA 1674489 c.288G>C synonymous_variant 0.18 ethionamide Uncertain significance
isoniazid Uncertain significance
inhA 1674656 p.Ser152Thr missense_variant 0.14 ethionamide Uncertain significance
isoniazid Uncertain significance
inhA 1674690 c.489C>G synonymous_variant 0.17 ethionamide Uncertain significance
isoniazid Uncertain significance
inhA 1674699 c.498C>T synonymous_variant 0.18 ethionamide Uncertain significance
isoniazid Uncertain significance
inhA 1674702 c.501G>C synonymous_variant 0.17 ethionamide Uncertain significance
isoniazid Uncertain significance
inhA 1674703 c.502T>C synonymous_variant 0.17 ethionamide Uncertain significance
isoniazid Uncertain significance
inhA 1674714 c.513C>G synonymous_variant 0.18 ethionamide Uncertain significance
isoniazid Uncertain significance
inhA 1674718 c.517A>C synonymous_variant 0.16 ethionamide Uncertain significance
isoniazid Uncertain significance
inhA 1674745 p.Tyr182Val missense_variant 0.17 ethionamide Uncertain significance
isoniazid Uncertain significance
inhA 1674750 c.549T>C synonymous_variant 0.17 ethionamide Uncertain significance
isoniazid Uncertain significance
inhA 1674756 c.555T>G synonymous_variant 0.19 ethionamide Uncertain significance
isoniazid Uncertain significance
inhA 1674765 c.564C>G synonymous_variant 0.19 ethionamide Uncertain significance
isoniazid Uncertain significance
inhA 1674771 c.570C>G synonymous_variant 0.19 ethionamide Uncertain significance
isoniazid Uncertain significance
inhA 1674774 c.573A>C synonymous_variant 0.2 ethionamide Uncertain significance
isoniazid Uncertain significance
inhA 1674777 c.576C>G synonymous_variant 0.2 ethionamide Uncertain significance
isoniazid Uncertain significance
inhA 1674780 c.579T>G synonymous_variant 0.19 ethionamide Uncertain significance
isoniazid Uncertain significance
inhA 1674801 c.600T>C synonymous_variant 0.19 ethionamide Uncertain significance
isoniazid Uncertain significance
inhA 1674804 c.603G>C synonymous_variant 0.19 ethionamide Not assoc w R - Interim
isoniazid Uncertain significance
inhA 1674810 c.609C>G synonymous_variant 0.17 ethionamide Uncertain significance
isoniazid Uncertain significance
inhA 1674819 c.618G>C synonymous_variant 0.18 ethionamide Uncertain significance
isoniazid Uncertain significance
inhA 1674825 c.624C>T synonymous_variant 0.17 ethionamide Uncertain significance
isoniazid Not assoc w R - Interim
rpsA 1833874 c.333T>C synonymous_variant 0.13 pyrazinamide Uncertain significance
rpsA 1833886 c.345C>G synonymous_variant 0.14 pyrazinamide Uncertain significance
rpsA 1833892 c.351G>A synonymous_variant 0.13 pyrazinamide Uncertain significance
rpsA 1833894 p.Ala118Glu missense_variant 0.13 pyrazinamide Uncertain significance
rpsA 1834051 c.510G>A synonymous_variant 0.13 pyrazinamide Uncertain significance
rpsA 1834105 c.564C>T synonymous_variant 0.14 pyrazinamide Uncertain significance
rpsA 1834150 c.609G>C synonymous_variant 0.14 pyrazinamide Uncertain significance
rpsA 1834153 c.612T>C synonymous_variant 0.14 pyrazinamide Uncertain significance
rpsA 1834154 p.Asn205Gln missense_variant 0.14 pyrazinamide Uncertain significance
rpsA 1834157 c.616T>C synonymous_variant 0.14 pyrazinamide Uncertain significance
rpsA 1834162 c.621A>G synonymous_variant 0.13 pyrazinamide Not assoc w R - Interim
rpsA 1834165 c.624A>G synonymous_variant 0.14 pyrazinamide Uncertain significance
rpsA 1834169 p.Thr210Ala missense_variant 0.14 pyrazinamide Uncertain significance
rpsA 1834172 p.Ile211Val missense_variant 0.13 pyrazinamide Uncertain significance
rpsA 1834177 c.636A>C synonymous_variant 0.13 pyrazinamide Not assoc w R - Interim
rpsA 1834189 c.648G>C synonymous_variant 0.14 pyrazinamide Uncertain significance
rpsA 1834222 c.681T>C synonymous_variant 0.17 pyrazinamide Uncertain significance
rpsA 1834225 c.684C>G synonymous_variant 0.17 pyrazinamide Uncertain significance
rpsA 1834231 c.690T>C synonymous_variant 0.16 pyrazinamide Uncertain significance
rpsA 1834240 c.699T>C synonymous_variant 0.17 pyrazinamide Uncertain significance
rpsA 1834249 c.708T>C synonymous_variant 0.17 pyrazinamide Uncertain significance
rpsA 1834261 c.720A>G synonymous_variant 0.15 pyrazinamide Not assoc w R - Interim
rpsA 1834264 c.723G>C synonymous_variant 0.15 pyrazinamide Uncertain significance
rpsA 1834294 c.753G>C synonymous_variant 0.14 pyrazinamide Uncertain significance
rpsA 1834297 c.756C>T synonymous_variant 0.14 pyrazinamide Uncertain significance
rpsA 1834303 c.762T>G synonymous_variant 0.13 pyrazinamide Uncertain significance
rpsA 1834306 c.765T>C synonymous_variant 0.13 pyrazinamide Uncertain significance
rpsA 1834366 c.825A>G synonymous_variant 0.13 pyrazinamide Not assoc w R - Interim
rpsA 1834396 c.855G>C synonymous_variant 0.14 pyrazinamide Uncertain significance
rpsA 1834411 c.870T>C synonymous_variant 0.15 pyrazinamide Uncertain significance
rpsA 1834423 c.882G>T synonymous_variant 0.13 pyrazinamide Uncertain significance
rpsA 1834432 c.891G>C synonymous_variant 0.12 pyrazinamide Uncertain significance
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
Rv2680 2996288 p.Ala62Thr missense_variant 1.0 capreomycin Uncertain significance
Rv3083 3448507 c.5_*1407del frameshift_variant&stop_lost&splice_region_variant 1.0 ethionamide Uncertain significance
mtrA 3627146 c.204C>T synonymous_variant 0.14 bedaquiline Uncertain significance
rifampicin Not assoc w R - Interim
mtrB 3627149 c.-536G>C upstream_gene_variant 0.13 bedaquiline Uncertain significance
rifampicin Uncertain significance
mtrB 3627152 c.-539C>T upstream_gene_variant 0.13 bedaquiline Uncertain significance
rifampicin Uncertain significance
alr 3840764 c.585G>C synonymous_variant 1.0 cycloserine Uncertain significance
rpoA 3877737 c.771G>C synonymous_variant 0.13 rifampicin Uncertain significance
rpoA 3877743 c.765T>C synonymous_variant 0.12 rifampicin Not assoc w R - Interim
rpoA 3877764 c.744C>G synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoA 3877770 c.738A>G synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoA 3877785 c.723C>A synonymous_variant 0.13 rifampicin Uncertain significance
rpoA 3877803 c.705G>C synonymous_variant 0.16 rifampicin Uncertain significance
rpoA 3877818 c.690A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoA 3877848 c.660C>T synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoA 3877856 c.652T>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoA 3877860 c.648C>T synonymous_variant 0.14 rifampicin Uncertain significance
rpoA 3877866 c.642G>C synonymous_variant 0.12 rifampicin Uncertain significance
rpoA 3877872 c.636C>T synonymous_variant 0.12 rifampicin Not assoc w R - Interim
rpoA 3877875 c.633T>C synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoA 3878247 c.261G>C synonymous_variant 0.13 rifampicin Uncertain significance
rpoA 3878250 c.258C>G synonymous_variant 0.13 rifampicin Uncertain significance
rpoA 3878264 p.Ser82Gly missense_variant 0.14 rifampicin Uncertain significance
rpoA 3878271 c.237T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoA 3878283 p.Glu75Asp missense_variant 0.14 rifampicin Uncertain significance
rpoA 3878298 c.210A>G synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoA 3878304 c.204G>C synonymous_variant 0.14 rifampicin Uncertain significance
rpoA 3878310 c.198G>C synonymous_variant 0.14 rifampicin Uncertain significance
clpC1 4038721 c.1984C>T synonymous_variant 0.13 pyrazinamide Uncertain significance
clpC1 4038727 p.Thr660Ser missense_variant 0.13 pyrazinamide Uncertain significance
clpC1 4040522 c.183T>C synonymous_variant 0.13 pyrazinamide Not assoc w R - Interim
clpC1 4040531 c.174T>G synonymous_variant 0.13 pyrazinamide Uncertain significance
clpC1 4040539 c.166C>T synonymous_variant 0.13 pyrazinamide Uncertain significance
clpC1 4040540 c.165G>T synonymous_variant 0.13 pyrazinamide Uncertain significance
clpC1 4040546 c.159G>C synonymous_variant 0.13 pyrazinamide Uncertain significance
clpC1 4040552 c.153G>C synonymous_variant 0.13 pyrazinamide Uncertain significance
clpC1 4040561 c.144A>G synonymous_variant 0.13 pyrazinamide Uncertain significance
clpC1 4040573 c.132T>A synonymous_variant 0.13 pyrazinamide Uncertain significance
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
embB 4248645 p.Ala711Asp missense_variant 1.0 ethambutol Uncertain significance
whiB6 4338427 p.Gly32Ala missense_variant 1.0 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 amikacin Not assoc w R
capreomycin Not assoc w R
kanamycin Not assoc w R