TB-Profiler result

Run: SRR6832249
Summary

Run ID: SRR6832249

Sample name:

Date: 2025-09-15T19:12:26.521695

Number of reads: 1959954

Percentage reads mapped: 80.62

Median coverage: 42.0

Strain: lineage2.2.1

Spoligotype:

Drug-resistance: Sensitive

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage2 East-Asian RD105 100.0
lineage2.2 East-Asian (Beijing) RD105;RD207 100.0
lineage2.2.1 East-Asian (Beijing) RD105;RD207;RD181 100.0
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
gyrB 5287 c.48T>C synonymous_variant 0.15 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrB 5293 c.54C>G synonymous_variant 0.17 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrB 5302 c.63A>G synonymous_variant 0.17 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrB 5305 c.66G>A synonymous_variant 0.16 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrB 5308 c.69G>A synonymous_variant 0.15 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 7090 c.-212C>T upstream_gene_variant 0.16 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrB 7093 c.1854T>C synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7099 c.-203G>A upstream_gene_variant 0.15 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 7108 c.-194G>A upstream_gene_variant 0.15 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 7120 c.-182T>C upstream_gene_variant 0.17 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7799 c.498A>G synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7832 c.531G>T synonymous_variant 0.17 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 7835 c.534A>C synonymous_variant 0.17 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 7838 c.537C>T synonymous_variant 0.17 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8315 c.1014G>A synonymous_variant 0.15 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8318 c.1017C>G synonymous_variant 0.17 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8324 c.1023T>C synonymous_variant 0.2 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8339 c.1038A>G synonymous_variant 0.17 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8340 p.Ala347Ser missense_variant 0.17 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8375 c.1074G>C synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Uncertain significance
gyrA 8399 c.1098T>C synonymous_variant 0.14 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8603 c.1302A>G synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8609 c.1308G>C synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8619 c.1318T>C synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8627 c.1326C>T synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8633 c.1332C>G synonymous_variant 0.2 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8645 c.1344C>T synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8981 c.1680G>C synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8998 p.Leu566Trp missense_variant 0.15 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9003 c.1702C>T synonymous_variant 0.16 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9017 c.1716C>T synonymous_variant 0.15 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9029 c.1728T>G synonymous_variant 0.15 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
fgd1 491043 c.261T>G synonymous_variant 0.21 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fgd1 491049 c.267T>G synonymous_variant 0.24 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fgd1 491063 p.Gly94Ala missense_variant 0.22 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fgd1 491067 c.285C>T synonymous_variant 0.23 clofazimine Not assoc w R - Interim
delamanid Uncertain significance
pretomanid Uncertain significance
fgd1 491077 p.Asn99Asp missense_variant 0.26 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fgd1 491085 c.303T>G synonymous_variant 0.25 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fgd1 491091 c.309T>G synonymous_variant 0.24 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fgd1 491094 c.312C>T synonymous_variant 0.24 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fgd1 491106 c.324T>C synonymous_variant 0.3 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fgd1 491742 c.960T>C synonymous_variant 1.0 clofazimine Not assoc w R
delamanid Not assoc w R - Interim
pretomanid Uncertain significance
mshA 575629 c.282A>T synonymous_variant 0.14 ethionamide Uncertain significance
isoniazid Uncertain significance
mshA 575633 p.Ala96Thr missense_variant 0.15 ethionamide Uncertain significance
isoniazid Uncertain significance
mshA 575652 p.Arg102Gln missense_variant 0.16 ethionamide Uncertain significance
isoniazid Uncertain significance
mshA 575907 p.Ala187Val missense_variant 0.98 ethionamide Not assoc w R
isoniazid Not assoc w R
ccsA 620625 p.Ile245Met missense_variant 1.0 amikacin Not assoc w R
capreomycin Not assoc w R
kanamycin Uncertain significance
Rv0565c 656841 c.630G>A synonymous_variant 1.0 ethionamide Not assoc w R - Interim
Rv0565c 657081 c.390G>A synonymous_variant 1.0 ethionamide Not assoc w R - Interim
Rv0565c 657142 p.Arg110His missense_variant 1.0 ethionamide Uncertain significance
Rv0565c 657644 c.-174G>C upstream_gene_variant 0.18 ethionamide Uncertain significance
Rv0565c 657647 c.-179_-177delGTCinsATT upstream_gene_variant 0.18 ethionamide Uncertain significance
hadA 732308 p.Val127Ile missense_variant 0.14 isoniazid Uncertain significance
nusG 734407 p.Val52Ile missense_variant 0.17 rifampicin Uncertain significance
nusG 734421 c.168A>G synonymous_variant 0.19 rifampicin Uncertain significance
nusG 734424 c.171G>T synonymous_variant 0.19 rifampicin Uncertain significance
nusG 734442 c.189G>A synonymous_variant 0.23 rifampicin Uncertain significance
nusG 734475 c.222T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
nusG 734481 c.228C>T synonymous_variant 0.19 rifampicin Uncertain significance
rpoB 759606 c.-201T>C upstream_gene_variant 0.17 rifampicin Uncertain significance
rpoB 759635 c.-172C>T upstream_gene_variant 0.19 rifampicin Uncertain significance
rpoB 759644 c.-163T>A upstream_gene_variant 0.19 rifampicin Uncertain significance
rpoB 759647 c.-160T>C upstream_gene_variant 0.2 rifampicin Uncertain significance
rpoB 759661 c.-146G>C upstream_gene_variant 0.15 rifampicin Uncertain significance
rpoB 759671 c.-136G>T upstream_gene_variant 0.14 rifampicin Uncertain significance
rpoB 760106 c.300G>C synonymous_variant 0.16 rifampicin Uncertain significance
rpoB 760112 c.306T>C synonymous_variant 0.16 rifampicin Uncertain significance
rpoB 760118 c.312T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760121 c.315T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760130 p.Asp108Glu missense_variant 0.19 rifampicin Uncertain significance
rpoB 760142 c.336C>G synonymous_variant 0.18 rifampicin Uncertain significance
rpoB 760298 c.492G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760307 c.501T>C synonymous_variant 0.17 rifampicin Uncertain significance
rpoB 760328 c.522G>C synonymous_variant 0.18 rifampicin Uncertain significance
rpoB 760340 c.534G>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760994 c.1188G>A synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 761006 c.1200C>T synonymous_variant 0.29 rifampicin Uncertain significance
rpoB 761015 c.1209G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 761027 c.1221A>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 761036 c.1230G>A synonymous_variant 0.31 rifampicin Uncertain significance
rpoB 761037 c.1231T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 761051 c.1245G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 761066 c.1260G>C synonymous_variant 0.28 rifampicin Uncertain significance
rpoB 761207 c.1401C>T synonymous_variant 0.16 rifampicin Uncertain significance
rpoB 761234 c.1428G>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 761255 c.1449T>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 761261 c.1455G>T synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 761273 c.1467T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 761300 c.1494G>A synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 761537 c.1731C>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 761561 c.1755C>G synonymous_variant 0.18 rifampicin Uncertain significance
rpoB 761564 c.1758G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761573 c.1767C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761600 c.1794T>G synonymous_variant 0.14 rifampicin Uncertain significance
rpoB 761603 c.1797C>T synonymous_variant 0.13 rifampicin Uncertain significance
rpoB 761606 c.1800C>G synonymous_variant 0.14 rifampicin Uncertain significance
rpoB 761612 c.1806G>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761615 c.1809A>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761954 c.2148C>G synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoB 762008 c.2202C>G synonymous_variant 0.16 rifampicin Uncertain significance
rpoB 762011 c.2205G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 762017 c.2211A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 762020 c.2214G>A synonymous_variant 0.15 rifampicin Uncertain significance
rpoB 762024 p.Val740Ile missense_variant 0.15 rifampicin Uncertain significance
rpoB 762899 c.3093G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 762929 c.3123G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 763028 c.3222T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>C synonymous_variant 1.0 rifampicin Not assoc w R
rpoB 763034 c.3228C>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 763040 c.3234C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 763050 c.-320C>T upstream_gene_variant 0.2 rifampicin Uncertain significance
rpoB 763070 c.3264T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 763076 c.-294C>T upstream_gene_variant 0.18 rifampicin Uncertain significance
rpoB 763085 c.3279C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 763094 c.3288G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 763115 c.3309T>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 763124 c.-246C>T upstream_gene_variant 0.14 rifampicin Uncertain significance
rpoB 763127 c.3321G>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 763169 c.-201A>G upstream_gene_variant 0.19 rifampicin Uncertain significance
rpoB 763193 c.3387C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 763430 c.61A>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 763435 c.66A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 763444 c.75T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 763456 c.87A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 763468 c.99G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 763486 c.117T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 763505 c.136C>T synonymous_variant 0.31 rifampicin Uncertain significance
rpoC 763561 c.192G>A synonymous_variant 0.26 rifampicin Uncertain significance
rpoC 763658 c.289_291delCTTinsTTG synonymous_variant 0.16 rifampicin Uncertain significance
rpoC 763666 c.297G>A synonymous_variant 0.22 rifampicin Uncertain significance
rpoC 763696 c.327T>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 763699 c.330G>C synonymous_variant 0.14 rifampicin Uncertain significance
rpoC 763702 c.333C>G synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 763714 c.345G>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 763717 c.348T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 763732 c.363C>G synonymous_variant 0.15 rifampicin Uncertain significance
rpoC 763735 c.366G>C synonymous_variant 0.15 rifampicin Uncertain significance
rpoC 763744 c.375G>C synonymous_variant 0.16 rifampicin Uncertain significance
rpoC 764317 c.948C>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764344 c.975C>T synonymous_variant 0.24 rifampicin Uncertain significance
rpoC 764347 c.978G>C synonymous_variant 0.24 rifampicin Uncertain significance
rpoC 764365 c.996C>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764575 c.1206T>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764576 c.1207_1208delTCinsAG synonymous_variant 0.17 rifampicin Uncertain significance
rpoC 764587 c.1218C>G synonymous_variant 0.15 rifampicin Uncertain significance
rpoC 764746 c.1377G>T synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 764755 c.1386C>T synonymous_variant 0.14 rifampicin Uncertain significance
rpoC 764764 c.1395T>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 764809 c.1440C>T synonymous_variant 0.13 rifampicin Not assoc w R
rpoC 764815 c.1446A>G synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 764902 c.1533C>G synonymous_variant 0.16 rifampicin Uncertain significance
rpoC 765445 c.2076G>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 765451 c.2082C>G synonymous_variant 0.17 rifampicin Uncertain significance
rpoC 765452 p.Ala695Ser missense_variant 0.16 rifampicin Uncertain significance
rpoC 765478 c.2109T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 765496 c.2127C>G synonymous_variant 0.31 rifampicin Uncertain significance
rpoC 765499 c.2130C>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 765526 c.2157C>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 765541 c.2172C>A synonymous_variant 0.24 rifampicin Uncertain significance
rpoC 765547 c.2178C>A synonymous_variant 0.23 rifampicin Uncertain significance
rpoC 765553 c.2184C>T synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 765556 c.2187G>C synonymous_variant 0.28 rifampicin Uncertain significance
rpoC 765562 c.2193G>C synonymous_variant 0.28 rifampicin Uncertain significance
rpoC 765583 c.2214G>T synonymous_variant 0.23 rifampicin Uncertain significance
rpoC 765586 c.2217G>A synonymous_variant 0.22 rifampicin Uncertain significance
rpoC 765589 c.2220G>C synonymous_variant 0.26 rifampicin Uncertain significance
rpoC 765610 c.2241C>T synonymous_variant 0.24 rifampicin Uncertain significance
rpoC 765850 c.2481G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 765883 c.2514C>G synonymous_variant 0.14 rifampicin Uncertain significance
rpoC 765886 c.2517C>G synonymous_variant 0.14 rifampicin Uncertain significance
rpoC 765892 c.2523T>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 765910 c.2541G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 765934 c.2565C>T synonymous_variant 0.19 rifampicin Uncertain significance
rpoC 765952 c.2583G>C synonymous_variant 0.17 rifampicin Uncertain significance
rpoC 765967 c.2598C>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 765979 c.2610C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 765994 c.2625A>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 765997 c.2628T>C synonymous_variant 0.16 rifampicin Uncertain significance
rpoC 766324 c.2955C>T synonymous_variant 0.2 rifampicin Uncertain significance
rpoC 766351 c.2982C>G synonymous_variant 0.26 rifampicin Uncertain significance
rpoC 766360 c.2991C>T synonymous_variant 0.26 rifampicin Uncertain significance
rpoC 766408 c.3039C>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 766417 c.3048C>T synonymous_variant 0.19 rifampicin Uncertain significance
rpoC 766519 c.3150C>A synonymous_variant 0.15 rifampicin Uncertain significance
rpoC 766597 c.3228C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 766607 p.Ile1080Leu missense_variant 0.23 rifampicin Uncertain significance
rpoC 766645 p.Glu1092Asp missense_variant 1.0 rifampicin Not assoc w R
rpoC 766651 c.3282T>C synonymous_variant 0.18 rifampicin Uncertain significance
rpoC 766774 c.3405T>C synonymous_variant 0.19 rifampicin Uncertain significance
rpoC 766792 c.3423C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 766795 c.3426C>T synonymous_variant 0.19 rifampicin Uncertain significance
rpoC 766843 c.3474T>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 766864 c.3495G>C synonymous_variant 0.26 rifampicin Uncertain significance
rpoC 766894 c.3525T>C synonymous_variant 0.22 rifampicin Uncertain significance
rpoC 766895 c.3526T>C synonymous_variant 0.22 rifampicin Uncertain significance
rpoC 766900 c.3531T>C synonymous_variant 0.24 rifampicin Uncertain significance
rpoC 766903 c.3534C>T synonymous_variant 0.24 rifampicin Uncertain significance
rpoC 766907 c.3538C>T synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 766918 c.3549C>T synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 766921 c.3552G>C synonymous_variant 0.28 rifampicin Uncertain significance
rpoC 766933 c.3564A>G synonymous_variant 0.31 rifampicin Uncertain significance
rpoC 766945 c.3576A>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 766963 c.3594T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 766972 c.3603G>C synonymous_variant 0.32 rifampicin Uncertain significance
rpoC 766975 c.3606C>T synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 766996 c.3627C>T synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 767002 c.3633G>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 767098 c.3729T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 767167 c.3798C>T synonymous_variant 0.16 rifampicin Uncertain significance
rpoC 767209 c.3840T>G synonymous_variant 0.16 rifampicin Uncertain significance
mmpL5 775639 p.Ile948Val missense_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
mmpL5 776100 p.Thr794Ile missense_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
mmpL5 776182 p.Asp767Asn missense_variant 1.0 bedaquiline Not assoc w R
clofazimine Not assoc w R
mmpS5 779615 c.-710C>G upstream_gene_variant 1.0 bedaquiline Uncertain significance
clofazimine Uncertain significance
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781709 c.150G>C synonymous_variant 0.13 streptomycin Not assoc w R - Interim
rpsL 781742 c.183C>T synonymous_variant 0.15 streptomycin Uncertain significance
rpsL 781760 c.201T>C synonymous_variant 0.15 streptomycin Uncertain significance
rpsL 781892 c.333A>G synonymous_variant 0.14 streptomycin Uncertain significance
rpsL 781898 c.339A>T synonymous_variant 0.14 streptomycin Uncertain significance
rpsL 781929 p.Gly124Ser missense_variant 0.16 streptomycin Uncertain significance
rplC 800600 c.-209G>T upstream_gene_variant 0.14 linezolid Uncertain significance
rplC 800609 c.-200G>A upstream_gene_variant 0.14 linezolid Uncertain significance
rplC 800618 c.-191T>C upstream_gene_variant 0.15 linezolid Uncertain significance
rplC 800714 c.-95C>T upstream_gene_variant 0.16 linezolid Uncertain significance
rplC 800715 c.-94A>C upstream_gene_variant 0.16 linezolid Uncertain significance
rplC 800720 c.-89T>C upstream_gene_variant 0.16 linezolid Uncertain significance
rplC 800723 c.-86C>G upstream_gene_variant 0.16 linezolid Uncertain significance
rplC 800759 c.-50C>T upstream_gene_variant 0.13 linezolid Uncertain significance
rplC 800771 c.-38C>T upstream_gene_variant 0.15 linezolid Uncertain significance
rplC 800865 c.57A>G synonymous_variant 0.23 linezolid Uncertain significance
rplC 800867 p.Ser20Asn missense_variant 0.24 linezolid Uncertain significance
rplC 800877 c.69A>C synonymous_variant 0.24 linezolid Uncertain significance
rplC 800907 c.99C>G synonymous_variant 0.26 linezolid Uncertain significance
rplC 800913 c.105G>C synonymous_variant 0.25 linezolid Uncertain significance
rplC 800916 c.108A>T synonymous_variant 0.22 linezolid Uncertain significance
rplC 800922 c.114C>G synonymous_variant 0.2 linezolid Uncertain significance
Rv1129c 1254562 c.-28T>C upstream_gene_variant 1.0 isoniazid Not assoc w R
levofloxacin Not assoc w R
moxifloxacin Not assoc w R
rifampicin Not assoc w R
fbiC 1303545 c.615A>G synonymous_variant 0.22 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1303551 c.621G>C synonymous_variant 0.24 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1303578 c.648G>A synonymous_variant 0.21 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1303584 c.654C>A synonymous_variant 0.23 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1304556 c.1626C>T synonymous_variant 0.35 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1304559 p.Glu543Asp missense_variant 0.33 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1304565 c.1635C>G synonymous_variant 0.3 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1304580 c.1650T>C synonymous_variant 0.3 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1304598 c.1668C>T synonymous_variant 0.35 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1304613 c.1683T>C synonymous_variant 0.3 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1304625 c.1695C>T synonymous_variant 0.31 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1304628 c.1698G>C synonymous_variant 0.29 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1304649 c.1719C>T synonymous_variant 0.21 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1304784 c.1854T>G synonymous_variant 0.24 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1304787 c.1857T>C synonymous_variant 0.25 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1304790 c.1860C>A synonymous_variant 0.24 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1304799 c.1869G>C synonymous_variant 0.24 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1304808 c.1878C>G synonymous_variant 0.19 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1304809 p.Ser627Glu missense_variant 0.19 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1304832 c.1902C>T synonymous_variant 0.17 clofazimine Not assoc w R - Interim
delamanid Not assoc w R - Interim
pretomanid Uncertain significance
fbiC 1304856 c.1926C>G synonymous_variant 0.16 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1305126 c.2196T>C synonymous_variant 0.14 clofazimine Not assoc w R - Interim
delamanid Not assoc w R - Interim
pretomanid Uncertain significance
sigE 1364706 c.294G>A synonymous_variant 0.95 pyrazinamide Not assoc w R - Interim
Rv1258c 1406760 c.580_581insC frameshift_variant 0.98 isoniazid Uncertain significance
pyrazinamide Uncertain significance
streptomycin Uncertain significance
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
streptomycin Uncertain significance
rrs 1471935 n.90T>C non_coding_transcript_exon_variant 0.21 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
streptomycin Uncertain significance
rrs 1471970 n.125G>A non_coding_transcript_exon_variant 0.13 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
streptomycin Uncertain significance
rrl 1473648 n.-9_-7delTTG upstream_gene_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473731 n.74T>A non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473887 n.230T>A non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473888 n.231T>A non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473898 n.241C>T non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474083 n.426C>T non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474140 n.483C>T non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474632 n.975G>T non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474639 n.982G>A non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474673 n.1016T>C non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474717 n.1060A>T non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>A non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474831 n.1174A>G non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475213 n.1556C>T non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475266 n.1609T>C non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475273 n.1616T>G non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475289 n.1632G>A non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475290 n.1633A>G non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475291 n.1634A>C non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475315 n.1658A>T non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475333 n.1676T>C non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475355 n.1698C>T non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475369 n.1712G>A non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.16 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476035 n.2378G>A non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476049 n.2392C>T non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476086 n.2429G>A non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476095 n.2438C>G non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476115 n.2458T>C non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476117 n.2460G>C non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476251 n.2594T>C non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476297 n.2640C>T non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476299 n.2642C>T non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rpsA 1833661 c.120A>G synonymous_variant 0.14 pyrazinamide Uncertain significance
rpsA 1833664 c.123C>A synonymous_variant 0.14 pyrazinamide Uncertain significance
rpsA 1833694 c.153G>T synonymous_variant 0.16 pyrazinamide Uncertain significance
rpsA 1833718 c.177C>T synonymous_variant 0.17 pyrazinamide Uncertain significance
rpsA 1833724 c.183C>G synonymous_variant 0.19 pyrazinamide Uncertain significance
rpsA 1833727 c.186G>C synonymous_variant 0.16 pyrazinamide Uncertain significance
rpsA 1833742 c.201A>G synonymous_variant 0.19 pyrazinamide Uncertain significance
rpsA 1833745 c.204G>C synonymous_variant 0.19 pyrazinamide Uncertain significance
rpsA 1833754 c.213G>A synonymous_variant 0.22 pyrazinamide Uncertain significance
rpsA 1833802 c.261A>G synonymous_variant 0.22 pyrazinamide Uncertain significance
rpsA 1833841 c.300C>G synonymous_variant 0.18 pyrazinamide Uncertain significance
rpsA 1833847 c.306C>G synonymous_variant 0.17 pyrazinamide Uncertain significance
rpsA 1833850 c.309C>G synonymous_variant 0.17 pyrazinamide Uncertain significance
rpsA 1833856 c.315A>G synonymous_variant 0.19 pyrazinamide Uncertain significance
rpsA 1833874 c.333T>C synonymous_variant 0.2 pyrazinamide Uncertain significance
rpsA 1833928 c.387G>C synonymous_variant 0.22 pyrazinamide Uncertain significance
rpsA 1833949 c.408T>C synonymous_variant 0.21 pyrazinamide Uncertain significance
rpsA 1833979 c.438T>C synonymous_variant 0.16 pyrazinamide Uncertain significance
rpsA 1834000 c.459G>C synonymous_variant 0.16 pyrazinamide Uncertain significance
rpsA 1834015 c.474G>C synonymous_variant 0.2 pyrazinamide Uncertain significance
rpsA 1834024 c.483G>A synonymous_variant 0.24 pyrazinamide Uncertain significance
rpsA 1834030 c.489C>G synonymous_variant 0.24 pyrazinamide Uncertain significance
rpsA 1834051 c.510G>A synonymous_variant 0.18 pyrazinamide Uncertain significance
rpsA 1834177 c.636A>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
rpsA 1834297 c.756C>T synonymous_variant 0.18 pyrazinamide Uncertain significance
rpsA 1834303 c.762T>G synonymous_variant 0.18 pyrazinamide Uncertain significance
rpsA 1834306 c.765T>C synonymous_variant 0.19 pyrazinamide Uncertain significance
rpsA 1834336 c.795C>G synonymous_variant 0.18 pyrazinamide Uncertain significance
rpsA 1834339 c.798C>T synonymous_variant 0.17 pyrazinamide Uncertain significance
rpsA 1834348 c.807T>C synonymous_variant 0.18 pyrazinamide Not assoc w R - Interim
rpsA 1834366 c.825A>G synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
rpsA 1834369 c.828C>G synonymous_variant 0.17 pyrazinamide Uncertain significance
rpsA 1834375 c.834G>A synonymous_variant 0.16 pyrazinamide Uncertain significance
rpsA 1834396 c.855G>C synonymous_variant 0.19 pyrazinamide Uncertain significance
rpsA 1834411 c.870T>C synonymous_variant 0.16 pyrazinamide Uncertain significance
rpsA 1834609 c.1068T>C synonymous_variant 0.16 pyrazinamide Uncertain significance
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
katG 2154724 p.Arg463Leu missense_variant 0.97 isoniazid Not assoc w R
katG 2155641 p.Lys157Asn missense_variant 0.22 isoniazid Uncertain significance
katG 2155649 p.Tyr155His missense_variant 0.24 isoniazid Uncertain significance
PPE35 2167926 p.Leu896Ser missense_variant 0.96 pyrazinamide Not assoc w R
PPE35 2169221 c.1392T>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
PPE35 2170623 c.-11G>A upstream_gene_variant 1.0 pyrazinamide Uncertain significance
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
kasA 2517941 c.-174C>G upstream_gene_variant 0.23 isoniazid Uncertain significance
kasA 2517956 c.-159G>A upstream_gene_variant 0.22 isoniazid Uncertain significance
kasA 2518798 c.684G>C synonymous_variant 0.15 isoniazid Uncertain significance
kasA 2518816 c.702C>T synonymous_variant 0.18 isoniazid Uncertain significance
kasA 2518822 c.708C>T synonymous_variant 0.18 isoniazid Uncertain significance
kasA 2518825 c.711T>C synonymous_variant 0.18 isoniazid Uncertain significance
kasA 2518855 c.741C>G synonymous_variant 0.15 isoniazid Uncertain significance
kasA 2518856 p.Ile248Leu missense_variant 0.15 isoniazid Uncertain significance
kasA 2518864 c.750G>C synonymous_variant 0.14 isoniazid Uncertain significance
eis 2714955 c.378C>T synonymous_variant 1.0 amikacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
eis 2715123 c.210G>T synonymous_variant 1.0 amikacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
Rv2477c 2783329 c.714G>A synonymous_variant 0.16 amikacin Uncertain significance
ethambutol Uncertain significance
kanamycin Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
streptomycin Uncertain significance
Rv2477c 2783332 c.711T>C synonymous_variant 0.16 amikacin Uncertain significance
ethambutol Uncertain significance
kanamycin Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
streptomycin Uncertain significance
Rv2477c 2783335 c.708C>T synonymous_variant 0.15 amikacin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
Rv2477c 2783356 c.687C>G synonymous_variant 0.16 amikacin Uncertain significance
ethambutol Uncertain significance
kanamycin Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
streptomycin Uncertain significance
Rv2477c 2783359 c.684G>A synonymous_variant 0.16 amikacin Uncertain significance
ethambutol Uncertain significance
kanamycin Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
streptomycin Uncertain significance
pepQ 2859489 p.Val310Ala missense_variant 0.22 bedaquiline Uncertain significance
clofazimine Uncertain significance
pepQ 2859510 c.909T>C synonymous_variant 0.19 bedaquiline Uncertain significance
clofazimine Uncertain significance
pepQ 2859528 c.891T>C synonymous_variant 0.18 bedaquiline Uncertain significance
clofazimine Uncertain significance
Rv2752c 3065625 c.567G>C synonymous_variant 0.19 ethambutol Uncertain significance
isoniazid Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
Rv2752c 3065634 c.558G>C synonymous_variant 0.18 ethambutol Uncertain significance
isoniazid Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
Rv2752c 3065637 c.555A>G synonymous_variant 0.16 ethambutol Uncertain significance
isoniazid Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
Rv2752c 3065640 c.552T>C synonymous_variant 0.16 ethambutol Uncertain significance
isoniazid Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
Rv2752c 3066573 c.-382G>C upstream_gene_variant 0.19 ethambutol Uncertain significance
isoniazid Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
Rv2752c 3066579 c.-388A>G upstream_gene_variant 0.19 ethambutol Uncertain significance
isoniazid Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
Rv2752c 3066592 c.-401A>C upstream_gene_variant 0.17 ethambutol Uncertain significance
isoniazid Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
Rv2752c 3066612 c.-421G>A upstream_gene_variant 0.17 ethambutol Uncertain significance
isoniazid Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
Rv2752c 3066618 c.-427A>G upstream_gene_variant 0.14 ethambutol Uncertain significance
isoniazid Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
thyA 3073947 c.525G>C synonymous_variant 0.17 para-aminosalicylic_acid Uncertain significance
thyA 3073989 c.483T>C synonymous_variant 0.23 para-aminosalicylic_acid Uncertain significance
thyA 3073997 c.475C>T synonymous_variant 0.23 para-aminosalicylic_acid Uncertain significance
thyA 3074004 c.468T>C synonymous_variant 0.2 para-aminosalicylic_acid Uncertain significance
thyA 3074031 c.441T>C synonymous_variant 0.26 para-aminosalicylic_acid Uncertain significance
thyA 3074037 c.435C>G synonymous_variant 0.22 para-aminosalicylic_acid Uncertain significance
thyA 3074045 c.427C>T synonymous_variant 0.22 para-aminosalicylic_acid Uncertain significance
thyA 3074053 p.Arg140Gln missense_variant 0.21 para-aminosalicylic_acid Uncertain significance
thyA 3074056 p.Glu139Pro missense_variant 0.23 para-aminosalicylic_acid Uncertain significance
thyA 3074061 p.Glu137Asp missense_variant 0.22 para-aminosalicylic_acid Uncertain significance
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine Uncertain significance
Rv3236c 3612813 p.Thr102Ala missense_variant 0.87 pyrazinamide Not assoc w R - Interim
lpqB 3623411 c.1500T>C synonymous_variant 0.23 bedaquiline Uncertain significance
rifampicin Uncertain significance
lpqB 3623428 c.1483T>C synonymous_variant 0.21 bedaquiline Uncertain significance
rifampicin Uncertain significance
lpqB 3623443 p.Ser490Thr missense_variant 0.19 bedaquiline Uncertain significance
rifampicin Uncertain significance
lpqB 3623444 c.1467T>C synonymous_variant 0.19 bedaquiline Uncertain significance
rifampicin Uncertain significance
lpqB 3623468 c.1443T>G synonymous_variant 0.17 bedaquiline Uncertain significance
rifampicin Not assoc w R - Interim
lpqB 3623471 c.1440C>T synonymous_variant 0.16 bedaquiline Uncertain significance
rifampicin Uncertain significance
lpqB 3624125 c.786A>G synonymous_variant 0.14 bedaquiline Uncertain significance
rifampicin Uncertain significance
lpqB 3624356 c.555C>T synonymous_variant 0.17 bedaquiline Uncertain significance
rifampicin Not assoc w R - Interim
lpqB 3624368 c.543C>G synonymous_variant 0.2 bedaquiline Uncertain significance
rifampicin Uncertain significance
lpqB 3624389 c.522C>G synonymous_variant 0.18 bedaquiline Uncertain significance
rifampicin Uncertain significance
mtrB 3625065 p.Met517Leu missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
mtrB 3625569 c.1045T>C synonymous_variant 0.14 bedaquiline Uncertain significance
rifampicin Not assoc w R - Interim
mtrB 3625572 p.Thr348Ser missense_variant 0.13 bedaquiline Uncertain significance
rifampicin Uncertain significance
mtrB 3626562 p.Pro18Ser missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
rpoA 3878271 c.237T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3878322 c.186A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3878331 c.177A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3878334 c.174T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3878337 c.171T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3878797 c.-290G>C upstream_gene_variant 0.23 rifampicin Uncertain significance
rpoA 3878824 c.-317G>C upstream_gene_variant 0.18 rifampicin Uncertain significance
rpoA 3878878 c.-371T>C upstream_gene_variant 0.31 rifampicin Uncertain significance
rpoA 3878909 c.-402A>G upstream_gene_variant 0.29 rifampicin Uncertain significance
rpoA 3878914 c.-407T>C upstream_gene_variant 0.28 rifampicin Uncertain significance
rpoA 3878920 c.-413C>T upstream_gene_variant 0.29 rifampicin Uncertain significance
rpoA 3878938 c.-431T>C upstream_gene_variant 0.21 rifampicin Uncertain significance
rpoA 3878947 c.-440G>C upstream_gene_variant 0.21 rifampicin Uncertain significance
rpoA 3878976 c.-469A>G upstream_gene_variant 0.18 rifampicin Uncertain significance
rpoA 3878977 c.-470C>G upstream_gene_variant 0.18 rifampicin Uncertain significance
clpC1 4038308 c.2397G>C synonymous_variant 0.15 pyrazinamide Uncertain significance
clpC1 4038314 c.2391T>G synonymous_variant 0.18 pyrazinamide Uncertain significance
clpC1 4038344 c.2361G>A synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
clpC1 4038383 c.2322G>A synonymous_variant 0.17 pyrazinamide Uncertain significance
clpC1 4038388 c.2317T>C synonymous_variant 0.17 pyrazinamide Uncertain significance
clpC1 4038392 c.2313C>T synonymous_variant 0.17 pyrazinamide Uncertain significance
clpC1 4038398 c.2307G>T synonymous_variant 0.16 pyrazinamide Uncertain significance
clpC1 4038403 c.2302T>C synonymous_variant 0.15 pyrazinamide Not assoc w R - Interim
clpC1 4038407 c.2298G>C synonymous_variant 0.17 pyrazinamide Uncertain significance
clpC1 4038419 c.2286T>C synonymous_variant 0.14 pyrazinamide Uncertain significance
clpC1 4038800 c.1905C>T synonymous_variant 0.26 pyrazinamide Uncertain significance
clpC1 4038812 c.1893T>C synonymous_variant 0.27 pyrazinamide Uncertain significance
clpC1 4038838 c.1867C>T synonymous_variant 0.34 pyrazinamide Uncertain significance
clpC1 4038839 c.1866G>C synonymous_variant 0.33 pyrazinamide Uncertain significance
clpC1 4038878 c.1827A>G synonymous_variant 0.31 pyrazinamide Not assoc w R - Interim
clpC1 4038923 c.1782A>G synonymous_variant 0.24 pyrazinamide Uncertain significance
clpC1 4039430 c.1275T>C synonymous_variant 0.15 pyrazinamide Uncertain significance
clpC1 4039442 c.1261_1263delCTAinsTTG synonymous_variant 0.16 pyrazinamide Uncertain significance
clpC1 4039448 c.1257A>G synonymous_variant 0.15 pyrazinamide Not assoc w R - Interim
clpC1 4039454 c.1251A>G synonymous_variant 0.15 pyrazinamide Not assoc w R - Interim
clpC1 4039601 c.1104G>C synonymous_variant 0.14 pyrazinamide Uncertain significance
clpC1 4039610 c.1095G>C synonymous_variant 0.13 pyrazinamide Uncertain significance
clpC1 4039616 c.1089G>C synonymous_variant 0.13 pyrazinamide Uncertain significance
clpC1 4040033 c.672G>C synonymous_variant 0.26 pyrazinamide Uncertain significance
clpC1 4040036 c.669C>G synonymous_variant 0.23 pyrazinamide Uncertain significance
clpC1 4040048 c.657C>T synonymous_variant 0.28 pyrazinamide Not assoc w R - Interim
clpC1 4040091 c.613_614delTCinsAG synonymous_variant 0.34 pyrazinamide Uncertain significance
clpC1 4040093 c.612C>G synonymous_variant 0.34 pyrazinamide Not assoc w R - Interim
clpC1 4040105 c.600C>G synonymous_variant 0.39 pyrazinamide Uncertain significance
clpC1 4040147 c.558A>G synonymous_variant 0.3 pyrazinamide Not assoc w R - Interim
clpC1 4040594 c.111G>T synonymous_variant 0.15 pyrazinamide Uncertain significance
clpC1 4040597 c.108C>T synonymous_variant 0.14 pyrazinamide Uncertain significance
clpC1 4040600 c.105A>G synonymous_variant 0.14 pyrazinamide Uncertain significance
clpC1 4040603 c.102T>G synonymous_variant 0.14 pyrazinamide Uncertain significance
clpC1 4040636 c.69C>G synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
clpC1 4040644 c.61A>C synonymous_variant 0.18 pyrazinamide Uncertain significance
clpC1 4040654 c.51G>A synonymous_variant 0.16 pyrazinamide Uncertain significance
clpC1 4040657 c.48T>G synonymous_variant 0.13 pyrazinamide Not assoc w R - Interim
embC 4240717 c.855T>C synonymous_variant 0.17 ethambutol Uncertain significance
embC 4240726 c.864G>C synonymous_variant 0.18 ethambutol Not assoc w R - Interim
embC 4240741 c.879C>T synonymous_variant 0.21 ethambutol Uncertain significance
embC 4240777 c.915G>A synonymous_variant 0.25 ethambutol Not assoc w R - Interim
embC 4240780 c.918T>C synonymous_variant 0.24 ethambutol Uncertain significance
embC 4240783 c.921G>C synonymous_variant 0.24 ethambutol Uncertain significance
embC 4240795 c.933C>G synonymous_variant 0.23 ethambutol Uncertain significance
embC 4240801 c.939C>T synonymous_variant 0.24 ethambutol Uncertain significance
embC 4240831 c.969T>C synonymous_variant 0.29 ethambutol Uncertain significance
embC 4240858 c.996G>A synonymous_variant 0.18 ethambutol Uncertain significance
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
embA 4243460 c.228C>T synonymous_variant 1.0 ethambutol Not assoc w R
embA 4245149 c.1917C>G synonymous_variant 0.2 ethambutol Uncertain significance
embA 4245182 c.1950T>C synonymous_variant 0.18 ethambutol Uncertain significance
embA 4245186 p.Thr652Ala missense_variant 0.18 ethambutol Uncertain significance
embA 4246020 p.Ala930Thr missense_variant 0.16 ethambutol Uncertain significance
embA 4246028 c.2796G>C synonymous_variant 0.17 ethambutol Not assoc w R - Interim
embB 4246070 c.-444G>C upstream_gene_variant 0.21 ethambutol Uncertain significance
embB 4246292 c.-222A>G upstream_gene_variant 0.27 ethambutol Uncertain significance
embB 4246307 c.-207G>C upstream_gene_variant 0.31 ethambutol Uncertain significance
embB 4246316 c.-198T>C upstream_gene_variant 0.28 ethambutol Uncertain significance
embB 4246346 c.-168C>G upstream_gene_variant 0.26 ethambutol Uncertain significance
embB 4247386 c.873T>C synonymous_variant 0.19 ethambutol Uncertain significance
embB 4247398 c.885G>C synonymous_variant 0.23 ethambutol Uncertain significance
embB 4247401 c.888T>C synonymous_variant 0.23 ethambutol Uncertain significance
embB 4247404 c.891G>C synonymous_variant 0.23 ethambutol Uncertain significance
embB 4247407 c.894G>C synonymous_variant 0.23 ethambutol Uncertain significance
embB 4247512 c.999T>C synonymous_variant 0.15 ethambutol Uncertain significance
embB 4248407 p.Leu632Val missense_variant 0.13 ethambutol Uncertain significance
aftB 4267647 p.Asp397Gly missense_variant 0.88 ethambutol Not assoc w R
aftB 4268994 c.-158T>C upstream_gene_variant 0.24 ethambutol Uncertain significance
aftB 4269000 c.-164G>A upstream_gene_variant 0.21 ethambutol Uncertain significance
aftB 4269006 c.-170T>C upstream_gene_variant 0.21 ethambutol Uncertain significance
aftB 4269012 c.-176G>C upstream_gene_variant 0.2 ethambutol Uncertain significance
aftB 4269027 c.-191C>G upstream_gene_variant 0.21 ethambutol Uncertain significance
aftB 4269030 c.-194C>G upstream_gene_variant 0.22 ethambutol Uncertain significance
aftB 4269033 c.-197T>C upstream_gene_variant 0.22 ethambutol Uncertain significance
aftB 4269045 c.-209G>C upstream_gene_variant 0.2 ethambutol Uncertain significance
ethA 4326535 c.939G>C synonymous_variant 0.14 ethionamide Uncertain significance
ethR 4326556 c.-993A>G upstream_gene_variant 0.2 ethionamide Uncertain significance
ethA 4326563 p.Ala304Gly missense_variant 0.19 ethionamide Uncertain significance
ethR 4326565 c.-984C>A upstream_gene_variant 0.19 ethionamide Uncertain significance
ethR 4327318 c.-231T>G upstream_gene_variant 0.23 ethionamide Uncertain significance
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 amikacin Not assoc w R
capreomycin Not assoc w R
kanamycin Not assoc w R
whiB6 4338711 c.-190C>A upstream_gene_variant 1.0 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
gid 4407588 c.615A>G synonymous_variant 1.0 streptomycin Not assoc w R
gid 4407927 p.Glu92Asp missense_variant 1.0 streptomycin Not assoc w R