TB-Profiler result

Run: SRR6832249
Summary

Run ID: SRR6832249

Sample name:

Date: 2024-10-04T15:32:40.231677

Number of reads: 1959954

Percentage reads mapped: 80.62

Median coverage: 42.0

Strain: lineage2.2.1

Spoligotype:

Drug-resistance: Sensitive

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage2 East-Asian RD105 0.98
lineage2.2.1 East-Asian (Beijing) RD105;RD207;RD181 0.99
lineage2.2 East-Asian (Beijing) RD105;RD207 0.97
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
gyrB 5287 c.48T>C synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrB 5293 c.54C>G synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrB 5302 c.63A>G synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrB 5305 c.66G>A synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrB 5308 c.69G>A synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 7090 c.-212C>T upstream_gene_variant 0.16 levofloxacin
moxifloxacin
gyrB 7093 c.1854T>C synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7099 c.-203G>A upstream_gene_variant 0.15 levofloxacin
moxifloxacin
gyrA 7108 c.-194G>A upstream_gene_variant 0.15 levofloxacin
moxifloxacin
gyrA 7120 c.-182T>C upstream_gene_variant 0.17 levofloxacin
moxifloxacin
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7799 c.498A>G synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7832 c.531G>T synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 7835 c.534A>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 7838 c.537C>T synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8315 c.1014G>A synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 8318 c.1017C>G synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8324 c.1023T>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8339 c.1038A>G synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8340 p.Ala347Ser missense_variant 0.17 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8375 c.1074G>C synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 8399 c.1098T>C synonymous_variant 0.14 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8603 c.1302A>G synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8609 c.1308G>C synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8619 c.1318T>C synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8627 c.1326C>T synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8633 c.1332C>G synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8645 c.1344C>T synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8981 c.1680G>C synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8998 p.Leu566Trp missense_variant 0.15 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9003 c.1702C>T synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 9017 c.1716C>T synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 9029 c.1728T>G synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
fgd1 491043 c.261T>G synonymous_variant 0.21 pretomanid
delamanid
clofazimine
fgd1 491049 c.267T>G synonymous_variant 0.24 pretomanid
delamanid
clofazimine
fgd1 491063 p.Gly94Ala missense_variant 0.22 pretomanid
delamanid
clofazimine
fgd1 491067 c.285C>T synonymous_variant 0.23 pretomanid
delamanid
clofazimine Not assoc w R - Interim
fgd1 491077 p.Asn99Asp missense_variant 0.26 pretomanid
delamanid
clofazimine
fgd1 491085 c.303T>G synonymous_variant 0.25 pretomanid
delamanid
clofazimine
fgd1 491091 c.309T>G synonymous_variant 0.24 pretomanid
delamanid
clofazimine
fgd1 491094 c.312C>T synonymous_variant 0.24 pretomanid
delamanid
clofazimine
fgd1 491106 c.324T>C synonymous_variant 0.3 pretomanid
delamanid
clofazimine
fgd1 491742 c.960T>C synonymous_variant 1.0 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R
mshA 575629 c.282A>T synonymous_variant 0.14 isoniazid
ethionamide
mshA 575633 p.Ala96Thr missense_variant 0.15 isoniazid
ethionamide
mshA 575652 p.Arg102Gln missense_variant 0.16 isoniazid
ethionamide
mshA 575907 p.Ala187Val missense_variant 0.98 isoniazid Not assoc w R
ethionamide Not assoc w R
ccsA 620625 p.Ile245Met missense_variant 1.0 kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
Rv0565c 656841 c.630G>A synonymous_variant 1.0 ethionamide Not assoc w R - Interim
Rv0565c 657081 c.390G>A synonymous_variant 1.0 ethionamide Not assoc w R - Interim
Rv0565c 657142 p.Arg110His missense_variant 1.0 ethionamide Uncertain significance
Rv0565c 657644 c.-174G>C upstream_gene_variant 0.18 ethionamide
Rv0565c 657647 c.-179_-177delGTCinsATT upstream_gene_variant 0.18 ethionamide
hadA 732308 p.Val127Ile missense_variant 0.14 isoniazid
nusG 734407 p.Val52Ile missense_variant 0.17 rifampicin
nusG 734421 c.168A>G synonymous_variant 0.19 rifampicin
nusG 734424 c.171G>T synonymous_variant 0.19 rifampicin
nusG 734442 c.189G>A synonymous_variant 0.23 rifampicin
nusG 734475 c.222T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
nusG 734481 c.228C>T synonymous_variant 0.19 rifampicin
rpoB 759606 c.-201T>C upstream_gene_variant 0.17 rifampicin
rpoB 759635 c.-172C>T upstream_gene_variant 0.19 rifampicin
rpoB 759644 c.-163T>A upstream_gene_variant 0.19 rifampicin
rpoB 759647 c.-160T>C upstream_gene_variant 0.2 rifampicin Uncertain significance
rpoB 759661 c.-146G>C upstream_gene_variant 0.15 rifampicin
rpoB 759671 c.-136G>T upstream_gene_variant 0.14 rifampicin
rpoB 760106 c.300G>C synonymous_variant 0.16 rifampicin
rpoB 760112 c.306T>C synonymous_variant 0.16 rifampicin
rpoB 760118 c.312T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760121 c.315T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760130 p.Asp108Glu missense_variant 0.19 rifampicin Uncertain significance
rpoB 760142 c.336C>G synonymous_variant 0.18 rifampicin
rpoB 760298 c.492G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760307 c.501T>C synonymous_variant 0.17 rifampicin
rpoB 760328 c.522G>C synonymous_variant 0.18 rifampicin
rpoB 760340 c.534G>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760994 c.1188G>A synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 761006 c.1200C>T synonymous_variant 0.29 rifampicin
rpoB 761015 c.1209G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 761027 c.1221A>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 761036 c.1230G>A synonymous_variant 0.31 rifampicin
rpoB 761037 c.1231T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 761051 c.1245G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 761066 c.1260G>C synonymous_variant 0.28 rifampicin
rpoB 761207 c.1401C>T synonymous_variant 0.16 rifampicin
rpoB 761234 c.1428G>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 761255 c.1449T>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 761261 c.1455G>T synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 761273 c.1467T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 761300 c.1494G>A synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 761537 c.1731C>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 761561 c.1755C>G synonymous_variant 0.18 rifampicin
rpoB 761564 c.1758G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761573 c.1767C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761600 c.1794T>G synonymous_variant 0.14 rifampicin
rpoB 761603 c.1797C>T synonymous_variant 0.13 rifampicin
rpoB 761606 c.1800C>G synonymous_variant 0.14 rifampicin
rpoB 761612 c.1806G>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761615 c.1809A>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761954 c.2148C>G synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoB 762008 c.2202C>G synonymous_variant 0.16 rifampicin
rpoB 762011 c.2205G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 762017 c.2211A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 762020 c.2214G>A synonymous_variant 0.15 rifampicin
rpoB 762024 p.Val740Ile missense_variant 0.15 rifampicin
rpoB 762899 c.3093G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 762929 c.3123G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 763028 c.3222T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>C synonymous_variant 1.0 rifampicin Not assoc w R
rpoB 763034 c.3228C>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 763040 c.3234C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 763050 c.-320C>T upstream_gene_variant 0.2 rifampicin
rpoB 763070 c.3264T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 763076 c.-294C>T upstream_gene_variant 0.18 rifampicin
rpoB 763085 c.3279C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 763094 c.3288G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 763115 c.3309T>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 763124 c.-246C>T upstream_gene_variant 0.14 rifampicin
rpoB 763127 c.3321G>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 763169 c.-201A>G upstream_gene_variant 0.19 rifampicin
rpoB 763193 c.3387C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 763430 c.61A>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 763435 c.66A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 763444 c.75T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 763456 c.87A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 763468 c.99G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 763486 c.117T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 763505 c.136C>T synonymous_variant 0.31 rifampicin
rpoC 763561 c.192G>A synonymous_variant 0.26 rifampicin
rpoC 763658 c.289_291delCTTinsTTG synonymous_variant 0.16 rifampicin
rpoC 763666 c.297G>A synonymous_variant 0.22 rifampicin
rpoC 763696 c.327T>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 763699 c.330G>C synonymous_variant 0.14 rifampicin
rpoC 763702 c.333C>G synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 763714 c.345G>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 763717 c.348T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 763732 c.363C>G synonymous_variant 0.15 rifampicin
rpoC 763735 c.366G>C synonymous_variant 0.15 rifampicin
rpoC 763744 c.375G>C synonymous_variant 0.16 rifampicin
rpoC 764317 c.948C>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764344 c.975C>T synonymous_variant 0.24 rifampicin
rpoC 764347 c.978G>C synonymous_variant 0.24 rifampicin
rpoC 764365 c.996C>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764575 c.1206T>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764576 c.1207_1208delTCinsAG synonymous_variant 0.17 rifampicin
rpoC 764587 c.1218C>G synonymous_variant 0.15 rifampicin
rpoC 764746 c.1377G>T synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 764755 c.1386C>T synonymous_variant 0.14 rifampicin
rpoC 764764 c.1395T>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 764809 c.1440C>T synonymous_variant 0.13 rifampicin Not assoc w R
rpoC 764815 c.1446A>G synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 764902 c.1533C>G synonymous_variant 0.16 rifampicin
rpoC 765445 c.2076G>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 765451 c.2082C>G synonymous_variant 0.17 rifampicin
rpoC 765452 p.Ala695Ser missense_variant 0.16 rifampicin
rpoC 765478 c.2109T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 765496 c.2127C>G synonymous_variant 0.31 rifampicin
rpoC 765499 c.2130C>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 765526 c.2157C>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 765541 c.2172C>A synonymous_variant 0.24 rifampicin
rpoC 765547 c.2178C>A synonymous_variant 0.23 rifampicin
rpoC 765553 c.2184C>T synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 765556 c.2187G>C synonymous_variant 0.28 rifampicin
rpoC 765562 c.2193G>C synonymous_variant 0.28 rifampicin
rpoC 765583 c.2214G>T synonymous_variant 0.23 rifampicin
rpoC 765586 c.2217G>A synonymous_variant 0.22 rifampicin
rpoC 765589 c.2220G>C synonymous_variant 0.26 rifampicin
rpoC 765610 c.2241C>T synonymous_variant 0.24 rifampicin
rpoC 765850 c.2481G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 765883 c.2514C>G synonymous_variant 0.14 rifampicin
rpoC 765886 c.2517C>G synonymous_variant 0.14 rifampicin
rpoC 765892 c.2523T>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 765910 c.2541G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 765934 c.2565C>T synonymous_variant 0.19 rifampicin
rpoC 765952 c.2583G>C synonymous_variant 0.17 rifampicin
rpoC 765967 c.2598C>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 765979 c.2610C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 765994 c.2625A>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 765997 c.2628T>C synonymous_variant 0.16 rifampicin
rpoC 766324 c.2955C>T synonymous_variant 0.2 rifampicin
rpoC 766351 c.2982C>G synonymous_variant 0.26 rifampicin
rpoC 766360 c.2991C>T synonymous_variant 0.26 rifampicin
rpoC 766408 c.3039C>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 766417 c.3048C>T synonymous_variant 0.19 rifampicin
rpoC 766519 c.3150C>A synonymous_variant 0.15 rifampicin
rpoC 766597 c.3228C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 766607 p.Ile1080Leu missense_variant 0.23 rifampicin
rpoC 766645 p.Glu1092Asp missense_variant 1.0 rifampicin Not assoc w R
rpoC 766651 c.3282T>C synonymous_variant 0.18 rifampicin
rpoC 766774 c.3405T>C synonymous_variant 0.19 rifampicin
rpoC 766792 c.3423C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 766795 c.3426C>T synonymous_variant 0.19 rifampicin
rpoC 766843 c.3474T>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 766864 c.3495G>C synonymous_variant 0.26 rifampicin
rpoC 766894 c.3525T>C synonymous_variant 0.22 rifampicin
rpoC 766895 c.3526T>C synonymous_variant 0.22 rifampicin
rpoC 766900 c.3531T>C synonymous_variant 0.24 rifampicin
rpoC 766903 c.3534C>T synonymous_variant 0.24 rifampicin
rpoC 766907 c.3538C>T synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 766918 c.3549C>T synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 766921 c.3552G>C synonymous_variant 0.28 rifampicin
rpoC 766933 c.3564A>G synonymous_variant 0.31 rifampicin
rpoC 766945 c.3576A>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 766963 c.3594T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 766972 c.3603G>C synonymous_variant 0.32 rifampicin
rpoC 766975 c.3606C>T synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 766996 c.3627C>T synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 767002 c.3633G>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 767098 c.3729T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 767167 c.3798C>T synonymous_variant 0.16 rifampicin
rpoC 767209 c.3840T>G synonymous_variant 0.16 rifampicin
mmpL5 775639 p.Ile948Val missense_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
mmpL5 776100 p.Thr794Ile missense_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
mmpL5 776182 p.Asp767Asn missense_variant 1.0 bedaquiline Not assoc w R
clofazimine Not assoc w R
mmpS5 779615 c.-710C>G upstream_gene_variant 1.0 bedaquiline
clofazimine
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781709 c.150G>C synonymous_variant 0.13 streptomycin Not assoc w R - Interim
rpsL 781742 c.183C>T synonymous_variant 0.15 streptomycin
rpsL 781760 c.201T>C synonymous_variant 0.15 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.14 streptomycin
rpsL 781898 c.339A>T synonymous_variant 0.14 streptomycin
rpsL 781929 p.Gly124Ser missense_variant 0.16 streptomycin Uncertain significance
rplC 800600 c.-209G>T upstream_gene_variant 0.14 linezolid
rplC 800609 c.-200G>A upstream_gene_variant 0.14 linezolid
rplC 800618 c.-191T>C upstream_gene_variant 0.15 linezolid
rplC 800714 c.-95C>T upstream_gene_variant 0.16 linezolid
rplC 800715 c.-94A>C upstream_gene_variant 0.16 linezolid
rplC 800720 c.-89T>C upstream_gene_variant 0.16 linezolid
rplC 800723 c.-86C>G upstream_gene_variant 0.16 linezolid
rplC 800759 c.-50C>T upstream_gene_variant 0.13 linezolid
rplC 800771 c.-38C>T upstream_gene_variant 0.15 linezolid
rplC 800865 c.57A>G synonymous_variant 0.23 linezolid
rplC 800867 p.Ser20Asn missense_variant 0.24 linezolid
rplC 800877 c.69A>C synonymous_variant 0.24 linezolid
rplC 800907 c.99C>G synonymous_variant 0.26 linezolid
rplC 800913 c.105G>C synonymous_variant 0.25 linezolid
rplC 800916 c.108A>T synonymous_variant 0.22 linezolid
rplC 800922 c.114C>G synonymous_variant 0.2 linezolid
Rv1129c 1254562 c.-28T>C upstream_gene_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
isoniazid Not assoc w R
rifampicin Not assoc w R
fbiC 1303545 c.615A>G synonymous_variant 0.22 pretomanid
delamanid
clofazimine
fbiC 1303551 c.621G>C synonymous_variant 0.24 pretomanid
delamanid
clofazimine
fbiC 1303578 c.648G>A synonymous_variant 0.21 pretomanid
delamanid
clofazimine
fbiC 1303584 c.654C>A synonymous_variant 0.23 pretomanid
delamanid
clofazimine
fbiC 1304556 c.1626C>T synonymous_variant 0.35 pretomanid
delamanid
clofazimine
fbiC 1304559 p.Glu543Asp missense_variant 0.33 pretomanid
delamanid
clofazimine
fbiC 1304565 c.1635C>G synonymous_variant 0.3 pretomanid
delamanid
clofazimine
fbiC 1304580 c.1650T>C synonymous_variant 0.3 pretomanid
delamanid
clofazimine
fbiC 1304598 c.1668C>T synonymous_variant 0.35 pretomanid
delamanid
clofazimine
fbiC 1304613 c.1683T>C synonymous_variant 0.3 pretomanid
delamanid
clofazimine
fbiC 1304625 c.1695C>T synonymous_variant 0.31 pretomanid
delamanid
clofazimine
fbiC 1304628 c.1698G>C synonymous_variant 0.29 pretomanid
delamanid
clofazimine
fbiC 1304649 c.1719C>T synonymous_variant 0.21 pretomanid
delamanid
clofazimine
fbiC 1304784 c.1854T>G synonymous_variant 0.24 pretomanid
delamanid
clofazimine
fbiC 1304787 c.1857T>C synonymous_variant 0.25 pretomanid
delamanid
clofazimine
fbiC 1304790 c.1860C>A synonymous_variant 0.24 pretomanid
delamanid
clofazimine
fbiC 1304799 c.1869G>C synonymous_variant 0.24 pretomanid
delamanid
clofazimine
fbiC 1304808 c.1878C>G synonymous_variant 0.19 pretomanid
delamanid
clofazimine
fbiC 1304809 p.Ser627Glu missense_variant 0.19 pretomanid
delamanid
clofazimine
fbiC 1304832 c.1902C>T synonymous_variant 0.17 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R - Interim
fbiC 1304856 c.1926C>G synonymous_variant 0.16 pretomanid
delamanid
clofazimine
fbiC 1305126 c.2196T>C synonymous_variant 0.14 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R - Interim
sigE 1364706 c.294G>A synonymous_variant 0.95 pyrazinamide Not assoc w R - Interim
Rv1258c 1406760 c.580_581insC frameshift_variant 0.98 streptomycin Uncertain significance
pyrazinamide Uncertain significance
isoniazid Uncertain significance
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 kanamycin
capreomycin
streptomycin
amikacin
rrs 1471935 n.90T>C non_coding_transcript_exon_variant 0.21 kanamycin
capreomycin
streptomycin
amikacin
rrs 1471970 n.125G>A non_coding_transcript_exon_variant 0.13 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrl 1473648 n.-9_-7delTTG upstream_gene_variant 0.22 capreomycin
linezolid
rrl 1473731 n.74T>A non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473887 n.230T>A non_coding_transcript_exon_variant 0.15 capreomycin
linezolid
rrl 1473888 n.231T>A non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473898 n.241C>T non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474083 n.426C>T non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid
rrl 1474140 n.483C>T non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474632 n.975G>T non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474639 n.982G>A non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474673 n.1016T>C non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474717 n.1060A>T non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>A non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474831 n.1174A>G non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid
rrl 1475213 n.1556C>T non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid
rrl 1475266 n.1609T>C non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475273 n.1616T>G non_coding_transcript_exon_variant 0.27 capreomycin
linezolid
rrl 1475289 n.1632G>A non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1475290 n.1633A>G non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1475291 n.1634A>C non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475315 n.1658A>T non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475333 n.1676T>C non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1475355 n.1698C>T non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475369 n.1712G>A non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.16 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476035 n.2378G>A non_coding_transcript_exon_variant 0.15 capreomycin
linezolid
rrl 1476049 n.2392C>T non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476086 n.2429G>A non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476095 n.2438C>G non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1476115 n.2458T>C non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476117 n.2460G>C non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476251 n.2594T>C non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476297 n.2640C>T non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476299 n.2642C>T non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rpsA 1833661 c.120A>G synonymous_variant 0.14 pyrazinamide
rpsA 1833664 c.123C>A synonymous_variant 0.14 pyrazinamide
rpsA 1833694 c.153G>T synonymous_variant 0.16 pyrazinamide
rpsA 1833718 c.177C>T synonymous_variant 0.17 pyrazinamide
rpsA 1833724 c.183C>G synonymous_variant 0.19 pyrazinamide
rpsA 1833727 c.186G>C synonymous_variant 0.16 pyrazinamide
rpsA 1833742 c.201A>G synonymous_variant 0.19 pyrazinamide
rpsA 1833745 c.204G>C synonymous_variant 0.19 pyrazinamide
rpsA 1833754 c.213G>A synonymous_variant 0.22 pyrazinamide
rpsA 1833802 c.261A>G synonymous_variant 0.22 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.18 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.17 pyrazinamide
rpsA 1833850 c.309C>G synonymous_variant 0.17 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.19 pyrazinamide
rpsA 1833874 c.333T>C synonymous_variant 0.2 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.22 pyrazinamide
rpsA 1833949 c.408T>C synonymous_variant 0.21 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.16 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.16 pyrazinamide
rpsA 1834015 c.474G>C synonymous_variant 0.2 pyrazinamide
rpsA 1834024 c.483G>A synonymous_variant 0.24 pyrazinamide
rpsA 1834030 c.489C>G synonymous_variant 0.24 pyrazinamide
rpsA 1834051 c.510G>A synonymous_variant 0.18 pyrazinamide
rpsA 1834177 c.636A>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
rpsA 1834297 c.756C>T synonymous_variant 0.18 pyrazinamide
rpsA 1834303 c.762T>G synonymous_variant 0.18 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.19 pyrazinamide
rpsA 1834336 c.795C>G synonymous_variant 0.18 pyrazinamide
rpsA 1834339 c.798C>T synonymous_variant 0.17 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 0.18 pyrazinamide Not assoc w R - Interim
rpsA 1834366 c.825A>G synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
rpsA 1834369 c.828C>G synonymous_variant 0.17 pyrazinamide
rpsA 1834375 c.834G>A synonymous_variant 0.16 pyrazinamide
rpsA 1834396 c.855G>C synonymous_variant 0.19 pyrazinamide
rpsA 1834411 c.870T>C synonymous_variant 0.16 pyrazinamide
rpsA 1834609 c.1068T>C synonymous_variant 0.16 pyrazinamide
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
katG 2154724 p.Arg463Leu missense_variant 0.97 isoniazid Not assoc w R
katG 2155641 p.Lys157Asn missense_variant 0.22 isoniazid Uncertain significance
katG 2155649 p.Tyr155His missense_variant 0.24 isoniazid
PPE35 2167926 p.Leu896Ser missense_variant 0.96 pyrazinamide Not assoc w R
PPE35 2169221 c.1392T>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
PPE35 2170623 c.-11G>A upstream_gene_variant 1.0 pyrazinamide Uncertain significance
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
kasA 2517941 c.-174C>G upstream_gene_variant 0.23 isoniazid
kasA 2517956 c.-159G>A upstream_gene_variant 0.22 isoniazid
kasA 2518798 c.684G>C synonymous_variant 0.15 isoniazid
kasA 2518816 c.702C>T synonymous_variant 0.18 isoniazid
kasA 2518822 c.708C>T synonymous_variant 0.18 isoniazid
kasA 2518825 c.711T>C synonymous_variant 0.18 isoniazid
kasA 2518855 c.741C>G synonymous_variant 0.15 isoniazid
kasA 2518856 p.Ile248Leu missense_variant 0.15 isoniazid
kasA 2518864 c.750G>C synonymous_variant 0.14 isoniazid
eis 2714955 c.378C>T synonymous_variant 1.0 kanamycin Not assoc w R - Interim
amikacin Not assoc w R - Interim
eis 2715123 c.210G>T synonymous_variant 1.0 kanamycin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783329 c.714G>A synonymous_variant 0.16 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783332 c.711T>C synonymous_variant 0.16 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783335 c.708C>T synonymous_variant 0.15 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783356 c.687C>G synonymous_variant 0.16 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783359 c.684G>A synonymous_variant 0.16 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
pepQ 2859489 p.Val310Ala missense_variant 0.22 bedaquiline
clofazimine
pepQ 2859510 c.909T>C synonymous_variant 0.19 bedaquiline
clofazimine
pepQ 2859528 c.891T>C synonymous_variant 0.18 bedaquiline
clofazimine
Rv2752c 3065625 c.567G>C synonymous_variant 0.19 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065634 c.558G>C synonymous_variant 0.18 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065637 c.555A>G synonymous_variant 0.16 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065640 c.552T>C synonymous_variant 0.16 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066573 c.-382G>C upstream_gene_variant 0.19 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066579 c.-388A>G upstream_gene_variant 0.19 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066592 c.-401A>C upstream_gene_variant 0.17 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066612 c.-421G>A upstream_gene_variant 0.17 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066618 c.-427A>G upstream_gene_variant 0.14 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
thyA 3073947 c.525G>C synonymous_variant 0.17 para-aminosalicylic_acid
thyA 3073989 c.483T>C synonymous_variant 0.23 para-aminosalicylic_acid
thyA 3073997 c.475C>T synonymous_variant 0.23 para-aminosalicylic_acid
thyA 3074004 c.468T>C synonymous_variant 0.2 para-aminosalicylic_acid
thyA 3074031 c.441T>C synonymous_variant 0.26 para-aminosalicylic_acid
thyA 3074037 c.435C>G synonymous_variant 0.22 para-aminosalicylic_acid
thyA 3074045 c.427C>T synonymous_variant 0.22 para-aminosalicylic_acid
thyA 3074053 p.Arg140Gln missense_variant 0.21 para-aminosalicylic_acid
thyA 3074056 p.Glu139Pro missense_variant 0.23 para-aminosalicylic_acid
thyA 3074061 p.Glu137Asp missense_variant 0.22 para-aminosalicylic_acid
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
Rv3236c 3612813 p.Thr102Ala missense_variant 0.87 pyrazinamide Not assoc w R - Interim
lpqB 3623411 c.1500T>C synonymous_variant 0.23 rifampicin
bedaquiline
lpqB 3623428 c.1483T>C synonymous_variant 0.21 rifampicin
bedaquiline
lpqB 3623443 p.Ser490Thr missense_variant 0.19 rifampicin
bedaquiline
lpqB 3623444 c.1467T>C synonymous_variant 0.19 rifampicin
bedaquiline
lpqB 3623468 c.1443T>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3623471 c.1440C>T synonymous_variant 0.16 rifampicin
bedaquiline
lpqB 3624125 c.786A>G synonymous_variant 0.14 rifampicin
bedaquiline
lpqB 3624356 c.555C>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3624368 c.543C>G synonymous_variant 0.2 rifampicin
bedaquiline
lpqB 3624389 c.522C>G synonymous_variant 0.18 rifampicin
bedaquiline
mtrB 3625065 p.Met517Leu missense_variant 1.0 rifampicin Not assoc w R
bedaquiline Uncertain significance
mtrB 3625569 c.1045T>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625572 p.Thr348Ser missense_variant 0.13 rifampicin
bedaquiline
mtrB 3626562 p.Pro18Ser missense_variant 1.0 rifampicin Not assoc w R
bedaquiline Uncertain significance
rpoA 3878271 c.237T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3878322 c.186A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3878331 c.177A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3878334 c.174T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3878337 c.171T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3878797 c.-290G>C upstream_gene_variant 0.23 rifampicin
rpoA 3878824 c.-317G>C upstream_gene_variant 0.18 rifampicin
rpoA 3878878 c.-371T>C upstream_gene_variant 0.31 rifampicin Uncertain significance
rpoA 3878909 c.-402A>G upstream_gene_variant 0.29 rifampicin
rpoA 3878914 c.-407T>C upstream_gene_variant 0.28 rifampicin Uncertain significance
rpoA 3878920 c.-413C>T upstream_gene_variant 0.29 rifampicin
rpoA 3878938 c.-431T>C upstream_gene_variant 0.21 rifampicin
rpoA 3878947 c.-440G>C upstream_gene_variant 0.21 rifampicin Uncertain significance
rpoA 3878976 c.-469A>G upstream_gene_variant 0.18 rifampicin Uncertain significance
rpoA 3878977 c.-470C>G upstream_gene_variant 0.18 rifampicin
clpC1 4038308 c.2397G>C synonymous_variant 0.15 pyrazinamide
clpC1 4038314 c.2391T>G synonymous_variant 0.18 pyrazinamide
clpC1 4038344 c.2361G>A synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
clpC1 4038383 c.2322G>A synonymous_variant 0.17 pyrazinamide
clpC1 4038388 c.2317T>C synonymous_variant 0.17 pyrazinamide
clpC1 4038392 c.2313C>T synonymous_variant 0.17 pyrazinamide
clpC1 4038398 c.2307G>T synonymous_variant 0.16 pyrazinamide
clpC1 4038403 c.2302T>C synonymous_variant 0.15 pyrazinamide Not assoc w R - Interim
clpC1 4038407 c.2298G>C synonymous_variant 0.17 pyrazinamide
clpC1 4038419 c.2286T>C synonymous_variant 0.14 pyrazinamide
clpC1 4038800 c.1905C>T synonymous_variant 0.26 pyrazinamide
clpC1 4038812 c.1893T>C synonymous_variant 0.27 pyrazinamide
clpC1 4038838 c.1867C>T synonymous_variant 0.34 pyrazinamide
clpC1 4038839 c.1866G>C synonymous_variant 0.33 pyrazinamide
clpC1 4038878 c.1827A>G synonymous_variant 0.31 pyrazinamide Not assoc w R - Interim
clpC1 4038923 c.1782A>G synonymous_variant 0.24 pyrazinamide
clpC1 4039430 c.1275T>C synonymous_variant 0.15 pyrazinamide
clpC1 4039442 c.1261_1263delCTAinsTTG synonymous_variant 0.16 pyrazinamide
clpC1 4039448 c.1257A>G synonymous_variant 0.15 pyrazinamide Not assoc w R - Interim
clpC1 4039454 c.1251A>G synonymous_variant 0.15 pyrazinamide Not assoc w R - Interim
clpC1 4039601 c.1104G>C synonymous_variant 0.14 pyrazinamide
clpC1 4039610 c.1095G>C synonymous_variant 0.13 pyrazinamide
clpC1 4039616 c.1089G>C synonymous_variant 0.13 pyrazinamide
clpC1 4040033 c.672G>C synonymous_variant 0.26 pyrazinamide
clpC1 4040036 c.669C>G synonymous_variant 0.23 pyrazinamide
clpC1 4040048 c.657C>T synonymous_variant 0.28 pyrazinamide Not assoc w R - Interim
clpC1 4040091 c.613_614delTCinsAG synonymous_variant 0.34 pyrazinamide
clpC1 4040093 c.612C>G synonymous_variant 0.34 pyrazinamide Not assoc w R - Interim
clpC1 4040105 c.600C>G synonymous_variant 0.39 pyrazinamide
clpC1 4040147 c.558A>G synonymous_variant 0.3 pyrazinamide Not assoc w R - Interim
clpC1 4040594 c.111G>T synonymous_variant 0.15 pyrazinamide
clpC1 4040597 c.108C>T synonymous_variant 0.14 pyrazinamide
clpC1 4040600 c.105A>G synonymous_variant 0.14 pyrazinamide
clpC1 4040603 c.102T>G synonymous_variant 0.14 pyrazinamide
clpC1 4040636 c.69C>G synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
clpC1 4040644 c.61A>C synonymous_variant 0.18 pyrazinamide
clpC1 4040654 c.51G>A synonymous_variant 0.16 pyrazinamide
clpC1 4040657 c.48T>G synonymous_variant 0.13 pyrazinamide Not assoc w R - Interim
embC 4240717 c.855T>C synonymous_variant 0.17 ethambutol
embC 4240726 c.864G>C synonymous_variant 0.18 ethambutol Not assoc w R - Interim
embC 4240741 c.879C>T synonymous_variant 0.21 ethambutol
embC 4240777 c.915G>A synonymous_variant 0.25 ethambutol Not assoc w R - Interim
embC 4240780 c.918T>C synonymous_variant 0.24 ethambutol
embC 4240783 c.921G>C synonymous_variant 0.24 ethambutol
embC 4240795 c.933C>G synonymous_variant 0.23 ethambutol
embC 4240801 c.939C>T synonymous_variant 0.24 ethambutol
embC 4240831 c.969T>C synonymous_variant 0.29 ethambutol
embC 4240858 c.996G>A synonymous_variant 0.18 ethambutol
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
embA 4243460 c.228C>T synonymous_variant 1.0 ethambutol Not assoc w R
embA 4245149 c.1917C>G synonymous_variant 0.2 ethambutol
embA 4245182 c.1950T>C synonymous_variant 0.18 ethambutol
embA 4245186 p.Thr652Ala missense_variant 0.18 ethambutol
embA 4246020 p.Ala930Thr missense_variant 0.16 ethambutol
embA 4246028 c.2796G>C synonymous_variant 0.17 ethambutol Not assoc w R - Interim
embB 4246070 c.-444G>C upstream_gene_variant 0.21 ethambutol
embB 4246292 c.-222A>G upstream_gene_variant 0.27 ethambutol
embB 4246307 c.-207G>C upstream_gene_variant 0.31 ethambutol
embB 4246316 c.-198T>C upstream_gene_variant 0.28 ethambutol
embB 4246346 c.-168C>G upstream_gene_variant 0.26 ethambutol
embB 4247386 c.873T>C synonymous_variant 0.19 ethambutol
embB 4247398 c.885G>C synonymous_variant 0.23 ethambutol
embB 4247401 c.888T>C synonymous_variant 0.23 ethambutol
embB 4247404 c.891G>C synonymous_variant 0.23 ethambutol
embB 4247407 c.894G>C synonymous_variant 0.23 ethambutol
embB 4247512 c.999T>C synonymous_variant 0.15 ethambutol
embB 4248407 p.Leu632Val missense_variant 0.13 ethambutol
aftB 4267647 p.Asp397Gly missense_variant 0.88 ethambutol Not assoc w R
aftB 4268994 c.-158T>C upstream_gene_variant 0.24 ethambutol
aftB 4269000 c.-164G>A upstream_gene_variant 0.21 ethambutol
aftB 4269006 c.-170T>C upstream_gene_variant 0.21 ethambutol
aftB 4269012 c.-176G>C upstream_gene_variant 0.2 ethambutol
aftB 4269027 c.-191C>G upstream_gene_variant 0.21 ethambutol
aftB 4269030 c.-194C>G upstream_gene_variant 0.22 ethambutol
aftB 4269033 c.-197T>C upstream_gene_variant 0.22 ethambutol
aftB 4269045 c.-209G>C upstream_gene_variant 0.2 ethambutol
ethA 4326535 c.939G>C synonymous_variant 0.14 ethionamide
ethR 4326556 c.-993A>G upstream_gene_variant 0.2 ethionamide
ethA 4326563 p.Ala304Gly missense_variant 0.19 ethionamide
ethR 4326565 c.-984C>A upstream_gene_variant 0.19 ethionamide
ethR 4327318 c.-231T>G upstream_gene_variant 0.23 ethionamide
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
whiB6 4338711 c.-190C>A upstream_gene_variant 1.0 kanamycin
capreomycin
amikacin
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 kanamycin
capreomycin
amikacin
gid 4407588 c.615A>G synonymous_variant 1.0 streptomycin Not assoc w R
gid 4407927 p.Glu92Asp missense_variant 1.0 streptomycin Not assoc w R