TB-Profiler result

Run: ERR11466499
Summary

Run ID: ERR11466499

Sample name:

Date: 2024-04-14T23:04:25.950950

Number of reads: 7222382

Percentage reads mapped: 98.05

Median coverage: 194.0

Strain: lineage4.3.4.1

Spoligotype:

Drug-resistance: Other

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage4.3 Euro-American (LAM) None 0.99
lineage4.3.4.1 Euro-American (LAM) RD174 0.98
lineage4 Euro-American None 1.0
lineage4.3.4 Euro-American (LAM) RD174 1.0
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol
pyrazinamide
streptomycin rrs n.462C>T Uncertain significance Mutation from literature
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid fbiC c.859_861delATCinsGG Assoc w R - Interim Confers DLM-PMD cross-resistance
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
fbiC 1303789 c.859_861delATCinsGG frameshift_variant&missense_variant 0.16 pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
rrs 1472307 n.462C>T non_coding_transcript_exon_variant 0.22 streptomycin Uncertain significance Mutation from literature
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
dnaA 1047 c.1047A>G synonymous_variant 0.14 isoniazid
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7585 p.Ser95Thr missense_variant 0.99 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9224 c.1923C>T synonymous_variant 0.14 levofloxacin
moxifloxacin
gyrA 9230 c.1929T>C synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 9233 c.1932C>G synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 9239 c.1938C>T synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9252 p.Val651Ile missense_variant 0.19 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9284 c.1983T>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 9291 c.1990C>T synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 9296 c.1995T>C synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9299 c.1998G>C synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9300 p.Ala667Ser missense_variant 0.18 levofloxacin
moxifloxacin
gyrA 9304 p.Gly668Glu missense_variant 1.0 levofloxacin
moxifloxacin
gyrA 9308 p.Asp669Glu missense_variant 0.19 levofloxacin
moxifloxacin
gyrA 9323 c.2022C>G synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9335 c.2034G>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 9344 c.2043C>T synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
Rv0010c 13483 p.Ala26Thr missense_variant 1.0 isoniazid Uncertain significance
ccsA 619609 c.-282G>C upstream_gene_variant 0.2 capreomycin
amikacin
kanamycin
ccsA 620424 c.534G>C synonymous_variant 0.17 capreomycin
amikacin
kanamycin
Rv0565c 656412 c.1059T>G synonymous_variant 0.13 ethionamide
Rv0565c 657701 c.-231C>G upstream_gene_variant 0.15 ethionamide
Rv0565c 657734 c.-264T>C upstream_gene_variant 0.18 ethionamide
hadA 732329 p.Leu134Val missense_variant 0.15 isoniazid Uncertain significance
hadA 732337 c.408G>A synonymous_variant 0.14 isoniazid
nusG 734451 c.198G>C synonymous_variant 0.14 rifampicin
nusG 734457 c.204C>G synonymous_variant 0.14 rifampicin
nusG 734472 c.219T>C synonymous_variant 0.18 rifampicin
nusG 734475 c.222T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760181 c.375T>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 760298 c.492G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 760307 c.501T>C synonymous_variant 0.17 rifampicin
rpoB 760310 c.504G>C synonymous_variant 0.17 rifampicin
rpoB 760328 c.522G>C synonymous_variant 0.18 rifampicin
rpoB 760331 c.525G>C synonymous_variant 0.18 rifampicin
rpoB 760340 c.534G>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760361 c.555T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760370 c.564C>G synonymous_variant 0.19 rifampicin
rpoB 760376 p.Asp190Glu missense_variant 0.18 rifampicin Uncertain significance
rpoB 760380 p.Thr192Leu missense_variant 0.17 rifampicin
rpoB 760406 c.600G>C synonymous_variant 0.27 rifampicin
rpoB 760412 c.606C>G synonymous_variant 0.25 rifampicin
rpoB 760424 c.618C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760430 c.624T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760475 c.669A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760481 c.675G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760484 c.678A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760946 c.1140A>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 760982 c.1176G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760985 c.1179G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 760991 c.1185G>C synonymous_variant 0.24 rifampicin
rpoB 761006 c.1200C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761015 c.1209G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761021 c.1215G>C synonymous_variant 0.2 rifampicin
rpoB 761027 c.1221A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 761036 c.1230G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761037 c.1231T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 761057 c.1251G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761102 c.1296A>G synonymous_variant 0.21 rifampicin
rpoB 761129 c.1323G>C synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoB 761133 c.1327T>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 761150 c.1344A>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 761153 c.1347G>C synonymous_variant 0.17 rifampicin
rpoB 761165 c.1359G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 761180 c.1374A>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761189 c.1383T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 761195 c.1389G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 761207 c.1401C>T synonymous_variant 0.18 rifampicin
rpoB 761213 c.1407G>C synonymous_variant 0.16 rifampicin
rpoB 761219 c.1413G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 761249 c.1443A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 761255 c.1449T>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761261 c.1455G>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761306 c.1500C>G synonymous_variant 0.2 rifampicin
rpoB 761312 c.1506G>C synonymous_variant 0.16 rifampicin
rpoB 761354 c.1548C>T synonymous_variant 0.16 rifampicin
rpoB 761362 p.Ser519Thr missense_variant 0.13 rifampicin
rpoB 761408 c.1602G>C synonymous_variant 0.2 rifampicin
rpoB 761414 c.1608A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 761423 c.1617T>C synonymous_variant 0.2 rifampicin
rpoB 761435 c.1629T>C synonymous_variant 0.2 rifampicin
rpoB 761438 c.1632G>C synonymous_variant 0.2 rifampicin
rpoB 761439 c.1633_1635delGACinsAG frameshift_variant&missense_variant 0.2 rifampicin
rpoB 761444 c.1638T>C synonymous_variant 0.2 rifampicin
rpoB 761447 c.1641C>G synonymous_variant 0.19 rifampicin
rpoB 761452 p.Val549Glu missense_variant 0.19 rifampicin
rpoB 761457 p.Pro551Ser missense_variant 0.2 rifampicin
rpoB 761477 c.1671C>G synonymous_variant 0.24 rifampicin
rpoB 761492 c.1686G>C synonymous_variant 0.19 rifampicin
rpoB 761510 c.1704T>C synonymous_variant 0.22 rifampicin
rpoB 761537 c.1731C>G synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 761570 c.1764T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 761573 c.1767C>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 761579 c.1773G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 761588 c.1782C>T synonymous_variant 0.16 rifampicin
rpoB 761606 c.1800C>G synonymous_variant 0.15 rifampicin
rpoB 761792 c.1986T>C synonymous_variant 0.15 rifampicin
rpoB 761834 c.2028T>C synonymous_variant 0.2 rifampicin
rpoB 761848 p.Cys681Ser missense_variant 0.17 rifampicin
rpoB 761852 c.2046C>G synonymous_variant 0.16 rifampicin
rpoB 761858 c.2052G>C synonymous_variant 0.18 rifampicin
rpoB 761861 c.2055C>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 761873 c.2067A>C synonymous_variant 0.2 rifampicin
rpoB 761885 c.2079T>C synonymous_variant 0.2 rifampicin
rpoB 761906 c.2100C>G synonymous_variant 0.17 rifampicin
rpoB 761909 c.2103T>C synonymous_variant 0.16 rifampicin
rpoB 761912 c.2106T>C synonymous_variant 0.16 rifampicin
rpoB 761915 p.Asp703Glu missense_variant 0.16 rifampicin
rpoB 761916 p.Asp704Asn missense_variant 0.16 rifampicin
rpoB 761948 c.2142G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 761954 c.2148C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 762008 c.2202C>T synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 762014 c.2208C>T synonymous_variant 0.26 rifampicin
rpoB 762017 c.2211A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 762053 c.2247T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 762062 c.2256T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 762083 c.2277T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 762086 c.2280G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 762101 c.2295C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 762114 p.Ile770Val missense_variant 0.19 rifampicin Uncertain significance
rpoB 762131 c.2325C>G synonymous_variant 0.17 rifampicin
rpoB 762140 c.2334G>C synonymous_variant 0.16 rifampicin
rpoB 762143 c.2337T>C synonymous_variant 0.16 rifampicin
rpoB 762149 c.2343G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 762185 c.2379G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 762206 c.2400C>G synonymous_variant 0.22 rifampicin
rpoB 762233 c.2427G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 762246 c.2440C>T synonymous_variant 0.24 rifampicin
rpoB 762254 c.2448T>G synonymous_variant 0.22 rifampicin
rpoB 762257 c.2451C>G synonymous_variant 0.22 rifampicin
rpoB 762266 c.2460T>C synonymous_variant 0.21 rifampicin
rpoB 762284 c.2478G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 762293 c.2487T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 762317 c.2511A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 762329 c.2523G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 762338 c.2532T>C synonymous_variant 0.21 rifampicin
rpoB 762347 c.2541T>C synonymous_variant 0.21 rifampicin
rpoB 762362 p.Glu852Asp missense_variant 0.17 rifampicin
rpoB 762369 c.2563T>C synonymous_variant 0.17 rifampicin
rpoC 762398 c.-972T>C upstream_gene_variant 0.18 rifampicin
rpoC 762401 c.-969G>C upstream_gene_variant 0.17 rifampicin
rpoB 762404 c.2598T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 762410 c.-960T>C upstream_gene_variant 0.22 rifampicin
rpoB 762416 c.2610A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 762419 c.-951C>G upstream_gene_variant 0.22 rifampicin
rpoC 762434 c.-936T>C upstream_gene_variant 0.21 rifampicin
rpoB 762449 c.2643C>A synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 762467 c.-903C>T upstream_gene_variant 0.26 rifampicin
rpoB 762488 c.2682G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 762489 p.Val895Gln missense_variant 0.18 rifampicin
rpoC 762509 c.-861T>G upstream_gene_variant 0.21 rifampicin
rpoB 762510 c.2704_2706delGCCinsCG frameshift_variant&missense_variant 0.21 rifampicin
rpoC 762521 c.-849C>T upstream_gene_variant 0.22 rifampicin
rpoC 762533 c.-837T>C upstream_gene_variant 0.15 rifampicin
rpoC 762536 c.-834T>C upstream_gene_variant 0.14 rifampicin
rpoC 762537 c.-833T>C upstream_gene_variant 0.14 rifampicin
rpoC 762551 c.-819C>G upstream_gene_variant 0.18 rifampicin
rpoC 763158 c.-212C>T upstream_gene_variant 0.15 rifampicin
rpoB 763166 c.3360A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 763170 c.-200C>T upstream_gene_variant 0.17 rifampicin
rpoC 763190 c.-180C>T upstream_gene_variant 0.16 rifampicin
rpoC 763441 c.72C>T synonymous_variant 0.17 rifampicin
rpoC 763444 c.75T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 763456 c.87A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 763486 c.117T>G synonymous_variant 0.15 rifampicin
rpoC 763546 c.177A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 763594 c.225C>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 763603 c.234C>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 763636 c.267T>C synonymous_variant 0.15 rifampicin
rpoC 763660 c.291T>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 763696 c.327T>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 763702 c.333C>G synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 763717 c.348T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 763723 c.354G>C synonymous_variant 0.15 rifampicin
rpoC 763732 c.363C>G synonymous_variant 0.19 rifampicin
rpoC 763741 c.372C>T synonymous_variant 0.15 rifampicin
rpoC 763744 c.375G>C synonymous_variant 0.15 rifampicin
rpoC 763774 c.405G>C synonymous_variant 0.17 rifampicin
rpoC 763807 c.438T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 763816 c.447C>G synonymous_variant 0.17 rifampicin
rpoC 763835 p.Ala156Met missense_variant 0.14 rifampicin
rpoC 763853 p.Val162Ile missense_variant 0.15 rifampicin
rpoC 763858 c.489A>G synonymous_variant 0.18 rifampicin
rpoC 764059 c.690G>T synonymous_variant 0.23 rifampicin
rpoC 764083 c.714A>G synonymous_variant 0.26 rifampicin
rpoC 764098 c.729A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764101 c.732C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764102 p.Val245Ile missense_variant 0.25 rifampicin
rpoC 764112 p.Tyr248Phe missense_variant 0.31 rifampicin
rpoC 764116 c.747C>T synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 764131 c.762T>C synonymous_variant 0.3 rifampicin
rpoC 764140 c.771C>T synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 764188 c.819A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764195 p.Ser276Ile missense_variant 0.21 rifampicin
rpoC 764203 c.834G>C synonymous_variant 0.21 rifampicin
rpoC 764206 c.837T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764215 c.846A>G synonymous_variant 0.24 rifampicin
rpoC 764236 c.867G>A synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764248 c.879C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764257 c.888G>C synonymous_variant 0.16 rifampicin
rpoC 764266 c.897T>C synonymous_variant 0.15 rifampicin
rpoC 764269 c.900G>C synonymous_variant 0.15 rifampicin
rpoC 764272 c.903G>C synonymous_variant 0.15 rifampicin
rpoC 764278 c.909A>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 764338 c.969G>A synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 764353 c.984G>C synonymous_variant 0.33 rifampicin
rpoC 764365 c.996C>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764380 c.1011G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 764381 c.1012_1013delTCinsAG synonymous_variant 0.16 rifampicin
rpoC 764387 c.1018_1020delTTGinsCC frameshift_variant&missense_variant 0.14 rifampicin
rpoC 764489 c.1120C>T synonymous_variant 0.15 rifampicin
rpoC 764510 c.1141C>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 764521 c.1152T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764527 c.1158C>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764536 c.1167G>C synonymous_variant 0.23 rifampicin
rpoC 764539 c.1170C>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764554 c.1185C>T synonymous_variant 0.29 rifampicin
rpoC 764560 c.1191T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764566 c.1197C>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764575 c.1206T>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 764581 c.1212T>C synonymous_variant 0.27 rifampicin
rpoC 764593 c.1224C>T synonymous_variant 0.22 rifampicin
rpoC 764611 c.1242G>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764809 c.1440C>T synonymous_variant 0.15 rifampicin Not assoc w R
rpoC 764815 c.1446A>G synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 764827 c.1458G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764858 c.1489T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764872 c.1503A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764888 c.1519T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764911 c.1542A>G synonymous_variant 0.18 rifampicin
rpoC 764995 c.1626C>G synonymous_variant 1.0 rifampicin Not assoc w R
rpoC 765292 c.1923G>C synonymous_variant 0.15 rifampicin
rpoC 765298 c.1929G>C synonymous_variant 0.17 rifampicin
rpoC 765300 p.Val644Ala missense_variant 0.16 rifampicin Uncertain significance
rpoC 765319 c.1950A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 765326 p.His653Ala missense_variant 0.17 rifampicin Uncertain significance
rpoC 765329 p.Ser654Gly missense_variant 0.17 rifampicin
rpoC 765346 c.1977C>G synonymous_variant 0.2 rifampicin
rpoC 765349 c.1980T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 765352 c.1983G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 765383 p.Met672Leu missense_variant 0.25 rifampicin Uncertain significance
rpoC 765404 p.Leu679Val missense_variant 0.25 rifampicin
rpoC 765409 c.2040T>C synonymous_variant 0.2 rifampicin
rpoC 765421 c.2052C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 765478 c.2109T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 765499 c.2130C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 765529 c.2160C>T synonymous_variant 0.21 rifampicin
rpoC 765541 c.2172C>G synonymous_variant 0.22 rifampicin
rpoC 765553 c.2184C>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 765556 c.2187G>C synonymous_variant 0.21 rifampicin
rpoC 765559 c.2190G>C synonymous_variant 0.22 rifampicin
rpoC 765580 c.2211G>C synonymous_variant 0.24 rifampicin
rpoC 765613 p.His748Gln missense_variant 0.26 rifampicin
rpoC 765625 c.2256C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 765631 p.Asp754Glu missense_variant 0.22 rifampicin
rpoC 765700 c.2331T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 765734 c.2365T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 765739 c.2370G>T synonymous_variant 0.3 rifampicin
rpoC 765751 c.2382C>G synonymous_variant 0.3 rifampicin
rpoC 765753 p.Asp795Ala missense_variant 0.29 rifampicin Uncertain significance
rpoC 765772 c.2403C>G synonymous_variant 0.29 rifampicin
rpoC 765784 c.2415C>G synonymous_variant 0.26 rifampicin
rpoC 765787 c.2418C>T synonymous_variant 0.26 rifampicin
rpoC 765793 c.2424C>G synonymous_variant 0.25 rifampicin
rpoC 765796 c.2427C>T synonymous_variant 0.25 rifampicin
rpoC 765811 c.2442T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 765814 c.2445A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 765826 c.2457T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 765835 c.2466C>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 765850 c.2481G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 765883 c.2514C>G synonymous_variant 0.24 rifampicin
rpoC 765886 c.2517C>G synonymous_variant 0.23 rifampicin
rpoC 765892 c.2523T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 765937 c.2568T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 765967 c.2598C>T synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 765982 c.2613C>G synonymous_variant 0.29 rifampicin
rpoC 765994 c.2625A>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 766010 c.2641_2642delTCinsAG synonymous_variant 0.25 rifampicin
rpoC 766021 c.2652G>C synonymous_variant 0.22 rifampicin
rpoC 766027 c.2658G>C synonymous_variant 0.19 rifampicin
rpoC 766030 c.2661C>G synonymous_variant 0.17 rifampicin
rpoC 766036 c.2667C>T synonymous_variant 0.17 rifampicin
rpoC 766043 p.Gln892Glu missense_variant 0.18 rifampicin
rpoC 766082 p.Ala905Gln missense_variant 0.18 rifampicin
rpoC 766096 c.2727G>C synonymous_variant 0.19 rifampicin
rpoC 766123 c.2754C>T synonymous_variant 0.14 rifampicin
rpoC 766327 c.2958C>A synonymous_variant 0.16 rifampicin
rpoC 766345 c.2976T>C synonymous_variant 0.18 rifampicin
rpoC 766348 c.2979A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 766357 c.2988C>T synonymous_variant 0.18 rifampicin
rpoC 766363 c.2994G>C synonymous_variant 0.17 rifampicin
rpoC 766381 c.3012C>T synonymous_variant 0.15 rifampicin
rpoC 766384 c.3015A>G synonymous_variant 0.15 rifampicin
rpoC 766408 c.3039C>G synonymous_variant 0.19 rifampicin
rpoC 766411 c.3042C>G synonymous_variant 0.2 rifampicin
rpoC 766426 c.3057C>T synonymous_variant 0.21 rifampicin
rpoC 766447 c.3078T>C synonymous_variant 0.22 rifampicin
rpoC 766462 c.3093G>C synonymous_variant 0.22 rifampicin
rpoC 766468 c.3099G>A synonymous_variant 0.21 rifampicin
rpoC 766483 c.3114G>C synonymous_variant 0.17 rifampicin
rpoC 766484 c.3115_3117delGTAinsAC frameshift_variant&missense_variant 0.17 rifampicin
rpoC 766492 c.3123T>C synonymous_variant 0.19 rifampicin
rpoC 766528 c.3159T>C synonymous_variant 0.17 rifampicin
rpoC 766531 c.3162G>C synonymous_variant 0.17 rifampicin
rpoC 766540 p.Asp1057Glu missense_variant 0.18 rifampicin
rpoC 766549 c.3180G>C synonymous_variant 0.17 rifampicin
rpoC 766738 c.3369G>C synonymous_variant 0.15 rifampicin
rpoC 766765 c.3396A>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 766774 c.3405T>C synonymous_variant 0.22 rifampicin
rpoC 766801 c.3432C>G synonymous_variant 0.16 rifampicin
rpoC 766804 c.3435A>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 766894 c.3525T>C synonymous_variant 0.15 rifampicin
rpoC 766900 c.3531T>C synonymous_variant 0.16 rifampicin
rpoC 766933 c.3564A>G synonymous_variant 0.17 rifampicin
rpoC 766945 c.3576A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 766963 c.3594T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 766972 c.3603G>C synonymous_variant 0.17 rifampicin
rpoC 766996 c.3627C>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 767009 c.3640_3642delTCGinsAGC synonymous_variant 0.16 rifampicin
rpoC 767014 c.3645G>C synonymous_variant 0.16 rifampicin
rpoC 767033 c.3664_3666delTCGinsAGC synonymous_variant 0.2 rifampicin
rpoC 767059 c.3690T>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 767062 c.3693C>A synonymous_variant 0.16 rifampicin
rpoC 767098 c.3729T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 767119 c.3750A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 767134 c.3765C>A synonymous_variant 0.15 rifampicin
mmpL5 775639 p.Ile948Val missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781628 c.69T>C synonymous_variant 0.16 streptomycin Not assoc w R - Interim
rpsL 781631 c.72G>C synonymous_variant 0.16 streptomycin
rpsL 781649 c.90T>C synonymous_variant 0.17 streptomycin
rpsL 781655 c.96T>C synonymous_variant 0.21 streptomycin
rpsL 781700 c.141G>C synonymous_variant 0.18 streptomycin
rpsL 781703 c.144G>T synonymous_variant 0.18 streptomycin
rpsL 781715 c.156T>C synonymous_variant 0.18 streptomycin
rpsL 781728 c.169T>C synonymous_variant 0.2 streptomycin
rpsL 781736 c.177T>C synonymous_variant 0.2 streptomycin
rpsL 781742 c.183C>T synonymous_variant 0.21 streptomycin
rpsL 781748 c.189C>G synonymous_variant 0.2 streptomycin
rpsL 781754 c.195G>C synonymous_variant 0.18 streptomycin
rpsL 781760 c.201T>C synonymous_variant 0.19 streptomycin
rpsL 781772 c.213C>A synonymous_variant 0.19 streptomycin
rpsL 781808 c.249C>T synonymous_variant 0.16 streptomycin
rpsL 781811 c.252C>T synonymous_variant 0.16 streptomycin
rpsL 781832 c.273T>C synonymous_variant 0.21 streptomycin
rpsL 781838 c.279G>C synonymous_variant 0.21 streptomycin
rpsL 781841 c.282C>G synonymous_variant 0.2 streptomycin
rpsL 781865 c.306G>C synonymous_variant 0.17 streptomycin
rpsL 781868 c.309T>C synonymous_variant 0.17 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.17 streptomycin
rpsL 781877 c.318T>C synonymous_variant 0.17 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.19 streptomycin
rpsL 781898 c.339A>T synonymous_variant 0.17 streptomycin
rpsL 781916 c.357T>C synonymous_variant 0.17 streptomycin
rpsL 781929 p.Gly124Ser missense_variant 0.19 streptomycin Uncertain significance
rplC 800516 c.-293G>T upstream_gene_variant 0.16 linezolid
rplC 800537 c.-272C>T upstream_gene_variant 0.16 linezolid
rplC 800540 c.-269T>C upstream_gene_variant 0.16 linezolid
rplC 800546 c.-263T>G upstream_gene_variant 0.19 linezolid
rplC 800567 c.-242A>G upstream_gene_variant 0.17 linezolid
rplC 800582 c.-227C>G upstream_gene_variant 0.17 linezolid
rplC 800612 c.-197A>G upstream_gene_variant 0.15 linezolid
rplC 800618 c.-191T>C upstream_gene_variant 0.17 linezolid
rplC 800627 c.-182C>T upstream_gene_variant 0.19 linezolid
rplC 800648 c.-161A>T upstream_gene_variant 0.15 linezolid
rplC 800654 c.-155T>C upstream_gene_variant 0.18 linezolid
rplC 800693 c.-116A>G upstream_gene_variant 0.16 linezolid
rplC 800703 c.-106T>C upstream_gene_variant 0.17 linezolid
rplC 800715 c.-94A>C upstream_gene_variant 0.18 linezolid
rplC 800720 c.-89T>C upstream_gene_variant 0.18 linezolid
rplC 800723 c.-86C>G upstream_gene_variant 0.19 linezolid
rplC 800747 c.-62C>G upstream_gene_variant 0.18 linezolid
rplC 800771 c.-38C>T upstream_gene_variant 0.18 linezolid
rplC 800814 c.6A>G synonymous_variant 0.14 linezolid
rplC 801309 c.501C>G synonymous_variant 0.14 linezolid
rplC 801312 c.504G>C synonymous_variant 0.13 linezolid
rplC 801357 c.549T>C synonymous_variant 0.16 linezolid
rplC 801367 p.Ala187Thr missense_variant 0.15 linezolid
fbiC 1303575 c.645G>C synonymous_variant 0.15 clofazimine
pretomanid
delamanid
fbiC 1303590 c.660A>G synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1303614 c.684C>T synonymous_variant 0.13 clofazimine
pretomanid
delamanid
fbiC 1303617 c.687C>G synonymous_variant 0.13 clofazimine
pretomanid
delamanid
fbiC 1303704 c.774T>C synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1303708 c.778T>C synonymous_variant 0.15 clofazimine
pretomanid
delamanid
fbiC 1303746 c.816T>C synonymous_variant 0.15 clofazimine
pretomanid
delamanid
fbiC 1303749 c.819G>C synonymous_variant 0.14 clofazimine
pretomanid
delamanid
fbiC 1303752 c.822A>G synonymous_variant 0.14 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1303755 c.825T>C synonymous_variant 0.15 clofazimine
pretomanid
delamanid
fbiC 1303761 c.831T>C synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1303785 c.855G>C synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1303797 c.867A>G synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1303818 c.888C>G synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1303836 c.906G>C synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1303845 c.915C>G synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1303846 p.Phe306Val missense_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1303854 c.924T>C synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1303860 c.930A>C synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1303866 p.Glu312Asp missense_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1303884 c.954T>G synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1303905 c.975G>C synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1303914 c.984C>G synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1303920 c.990C>T synonymous_variant 0.14 clofazimine
pretomanid
delamanid
sigE 1364434 p.Arg8Trp missense_variant 1.0 pyrazinamide Not assoc w R
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473105 n.1260G>A non_coding_transcript_exon_variant 0.17 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.18 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.19 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrl 1473756 n.99G>A non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1473758 n.101G>T non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid
rrl 1473806 n.149C>T non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473877 n.220G>A non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1473898 n.241C>T non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473943 n.286G>T non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid
rrl 1473945 n.288T>A non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid
rrl 1473946 n.289A>T non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid
rrl 1473986 n.329T>C non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
rrl 1473987 n.330G>A non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
rrl 1473995 n.338G>T non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1474001 n.344C>T non_coding_transcript_exon_variant 0.19 capreomycin Not assoc w R
linezolid Not assoc w R
rrl 1474009 n.352A>G non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
rrl 1474012 n.355C>T non_coding_transcript_exon_variant 0.15 capreomycin
linezolid
rrl 1474093 n.436G>T non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1474099 n.442G>A non_coding_transcript_exon_variant 0.27 capreomycin
linezolid
rrl 1474103 n.446A>T non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1474140 n.483C>T non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474181 n.524C>T non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474356 n.699T>C non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid
rrl 1474362 n.705A>G non_coding_transcript_exon_variant 0.14 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474376 n.719T>C non_coding_transcript_exon_variant 0.14 capreomycin
linezolid
rrl 1474639 n.982G>A non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474823 n.1166C>T non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1474831 n.1174A>G non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid
rrl 1474904 n.1247G>A non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
rrl 1475006 n.1349A>T non_coding_transcript_exon_variant 0.15 capreomycin
linezolid
rrl 1475061 n.1404C>T non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid
rrl 1475088 n.1431A>T non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1475199 n.1542G>A non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1475206 n.1549C>T non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid
rrl 1475209 n.1552G>C non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid
rrl 1475213 n.1556C>T non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid
rrl 1475249 n.1592T>C non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475252 n.1595C>T non_coding_transcript_exon_variant 0.14 capreomycin
linezolid
rrl 1475266 n.1609T>C non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475267 n.1610G>A non_coding_transcript_exon_variant 0.15 capreomycin
linezolid
rrl 1475275 n.1618C>T non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
rrl 1475276 n.1619T>C non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
rrl 1475313 n.1656G>A non_coding_transcript_exon_variant 0.14 capreomycin
linezolid
rrl 1475505 n.1848G>A non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475599 n.1942A>G non_coding_transcript_exon_variant 0.2 capreomycin
linezolid Uncertain significance
rrl 1475608 n.1951T>C non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid
rrl 1475642 n.1985T>C non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1475657 n.2000A>G non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1475659 n.2002G>T non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1475761 n.2104_2106delCGCinsGT non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1475765 n.2111delG non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1475881 n.2224T>C non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1476115 n.2458T>C non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476117 n.2460G>C non_coding_transcript_exon_variant 0.15 capreomycin
linezolid
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476583 n.2926G>A non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.15 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476594 n.2937C>T non_coding_transcript_exon_variant 0.18 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476597 n.2940G>A non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid
rrl 1476603 n.2946G>A non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476608 n.2951C>G non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid Uncertain significance
inhA 1673955 c.-247G>C upstream_gene_variant 0.14 ethionamide
isoniazid
inhA 1673961 c.-241A>C upstream_gene_variant 0.14 ethionamide
isoniazid
fabG1 1674006 p.Asp189Glu missense_variant 0.16 ethionamide
isoniazid
rpsA 1833568 c.27G>C synonymous_variant 0.14 pyrazinamide Not assoc w R - Interim
rpsA 1833589 c.48A>T synonymous_variant 0.16 pyrazinamide
rpsA 1833595 c.54T>C synonymous_variant 0.16 pyrazinamide
rpsA 1833661 c.120A>G synonymous_variant 0.2 pyrazinamide
rpsA 1833667 c.126C>G synonymous_variant 0.18 pyrazinamide
rpsA 1833721 c.180A>G synonymous_variant 0.16 pyrazinamide
rpsA 1833724 c.183C>G synonymous_variant 0.16 pyrazinamide
rpsA 1833787 c.246C>G synonymous_variant 0.17 pyrazinamide
rpsA 1833790 c.249T>C synonymous_variant 0.16 pyrazinamide
rpsA 1833802 c.261A>G synonymous_variant 0.19 pyrazinamide
rpsA 1833811 c.270G>T synonymous_variant 0.18 pyrazinamide
rpsA 1833838 c.297G>C synonymous_variant 0.18 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.18 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.22 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.19 pyrazinamide
rpsA 1833874 c.333T>C synonymous_variant 0.18 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.15 pyrazinamide
rpsA 1833940 c.399C>G synonymous_variant 0.16 pyrazinamide
rpsA 1833971 c.430C>T synonymous_variant 0.14 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.16 pyrazinamide
rpsA 1834021 c.480C>T synonymous_variant 0.15 pyrazinamide
rpsA 1834030 c.489C>G synonymous_variant 0.15 pyrazinamide
rpsA 1834123 c.582C>G synonymous_variant 0.14 pyrazinamide
tsnR 1853361 c.-245T>C upstream_gene_variant 0.2 linezolid
tsnR 1853370 c.-236_-234delGCAinsTG upstream_gene_variant 0.22 linezolid
tsnR 1853387 c.-219T>G upstream_gene_variant 0.21 linezolid
tsnR 1853394 c.-212_-211delCTinsGC upstream_gene_variant 0.18 linezolid
tsnR 1853420 c.-186T>G upstream_gene_variant 0.19 linezolid
tsnR 1853429 c.-177G>C upstream_gene_variant 0.13 linezolid
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
tlyA 1917990 c.51G>C synonymous_variant 0.14 capreomycin
tlyA 1917993 c.54A>G synonymous_variant 0.13 capreomycin Not assoc w R - Interim
tlyA 1917996 c.57A>G synonymous_variant 0.13 capreomycin
PPE35 2169910 p.Asn235Tyr missense_variant 0.15 pyrazinamide
Rv1979c 2222854 p.Ile104Thr missense_variant 1.0 clofazimine Uncertain significance
bedaquiline Uncertain significance
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
kasA 2517950 c.-165C>G upstream_gene_variant 0.16 isoniazid
kasA 2518864 c.750G>C synonymous_variant 0.15 isoniazid
Rv2477c 2783182 c.861C>G synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783185 c.858G>A synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783194 c.849A>G synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783221 c.822G>C synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783224 c.819C>G synonymous_variant 0.15 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783230 c.813T>G synonymous_variant 0.14 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783254 c.789A>G synonymous_variant 0.14 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783263 c.780G>C synonymous_variant 0.14 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783344 c.699C>G synonymous_variant 0.14 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783656 c.387G>C synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783665 c.378A>G synonymous_variant 0.15 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783674 c.369T>C synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783683 c.360A>G synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783700 p.Thr115Ser missense_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783718 c.325T>C synonymous_variant 0.15 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783719 c.324A>G synonymous_variant 0.15 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783737 c.306C>A synonymous_variant 0.15 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783751 p.Ile98Val missense_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783758 p.Asp95Glu missense_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783761 c.282G>C synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783766 p.Met93Leu missense_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783797 p.Asp82Glu missense_variant 0.15 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783883 c.160T>C synonymous_variant 0.15 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783884 c.159T>C synonymous_variant 0.15 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783887 c.156C>G synonymous_variant 0.15 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783914 c.129T>C synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783920 c.123G>C synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783929 c.114C>G synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783932 c.111C>T synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783938 c.105T>C synonymous_variant 0.14 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783971 c.72G>C synonymous_variant 0.15 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783980 c.63C>G synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2752c 3066522 c.-331C>G upstream_gene_variant 0.16 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066531 c.-340C>G upstream_gene_variant 0.16 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
thyA 3073868 p.Thr202Ala missense_variant 0.98 para-aminosalicylic_acid
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
Rv3236c 3612009 p.Ala370Thr missense_variant 0.98 pyrazinamide Not assoc w R
mtrB 3625065 p.Met517Leu missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
mtrB 3625569 c.1045T>C synonymous_variant 0.15 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625572 p.Thr348Ser missense_variant 0.15 bedaquiline
rifampicin
lpqB 3625579 c.-669A>G upstream_gene_variant 0.17 bedaquiline
rifampicin
lpqB 3625594 c.-684T>C upstream_gene_variant 0.17 bedaquiline
rifampicin
lpqB 3625602 c.-692T>C upstream_gene_variant 0.16 bedaquiline
rifampicin
lpqB 3625612 c.-702G>C upstream_gene_variant 0.16 bedaquiline
rifampicin
mtrB 3625616 p.Arg333Ala missense_variant 0.15 bedaquiline
rifampicin
lpqB 3625624 c.-714C>G upstream_gene_variant 0.17 bedaquiline
rifampicin
mtrB 3625636 c.978C>G synonymous_variant 0.18 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625656 c.958T>C synonymous_variant 0.14 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
mtrB 3626987 c.-374C>G upstream_gene_variant 0.13 bedaquiline
rifampicin
mtrA 3627098 c.252A>C synonymous_variant 0.16 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627104 c.-491C>G upstream_gene_variant 0.14 bedaquiline
rifampicin
mtrA 3627119 c.231T>G synonymous_variant 0.17 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627122 c.-509T>C upstream_gene_variant 0.17 bedaquiline
rifampicin
mtrB 3627167 c.-554T>C upstream_gene_variant 0.19 bedaquiline
rifampicin
mtrB 3627181 c.-568T>C upstream_gene_variant 0.18 bedaquiline
rifampicin
mtrB 3627182 c.-569T>C upstream_gene_variant 0.18 bedaquiline
rifampicin
mtrA 3627188 c.162A>G synonymous_variant 0.2 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627209 c.-596G>A upstream_gene_variant 0.22 bedaquiline
rifampicin
mtrA 3627221 c.129C>T synonymous_variant 0.24 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3627227 c.123T>C synonymous_variant 0.23 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627233 c.-620T>C upstream_gene_variant 0.18 bedaquiline
rifampicin
mtrB 3627236 c.-623T>C upstream_gene_variant 0.18 bedaquiline
rifampicin
mtrA 3627242 c.108C>T synonymous_variant 0.2 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627254 c.-641C>T upstream_gene_variant 0.19 bedaquiline
rifampicin
mtrB 3627263 c.-650C>T upstream_gene_variant 0.17 bedaquiline
rifampicin
mtrB 3627266 c.-653A>G upstream_gene_variant 0.17 bedaquiline
rifampicin
mtrB 3627272 c.-659G>T upstream_gene_variant 0.17 bedaquiline
rifampicin
mtrB 3627275 c.-662G>T upstream_gene_variant 0.17 bedaquiline
rifampicin
rpoA 3877587 c.921A>G synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoA 3877613 p.Ile299Val missense_variant 0.2 rifampicin
rpoA 3877656 c.852T>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3877668 c.840A>G synonymous_variant 0.18 rifampicin
rpoA 3877679 p.Ala277Ser missense_variant 0.21 rifampicin
rpoA 3877686 c.822A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoA 3877692 c.816G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoA 3877704 c.804G>C synonymous_variant 0.16 rifampicin
rpoA 3877737 c.771G>C synonymous_variant 0.19 rifampicin
rpoA 3877743 c.765T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3877748 c.760C>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3877764 c.744C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3877770 c.738A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3877776 c.732T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3877782 c.726T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3877791 c.717C>G synonymous_variant 0.19 rifampicin
rpoA 3877818 c.690A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3877839 c.669G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoA 3879121 c.-614T>G upstream_gene_variant 0.14 rifampicin
rpoA 3879178 c.-671T>C upstream_gene_variant 0.14 rifampicin
clpC1 4038287 c.2418C>T synonymous_variant 0.99 pyrazinamide Not assoc w R
clpC1 4038755 c.1950G>T synonymous_variant 0.14 pyrazinamide
clpC1 4038770 c.1935C>T synonymous_variant 0.14 pyrazinamide
clpC1 4038773 c.1932T>C synonymous_variant 0.14 pyrazinamide
clpC1 4038782 c.1923G>C synonymous_variant 0.17 pyrazinamide
clpC1 4038812 c.1893T>C synonymous_variant 0.17 pyrazinamide
clpC1 4038845 c.1860G>C synonymous_variant 0.21 pyrazinamide
clpC1 4038860 c.1845G>C synonymous_variant 0.18 pyrazinamide Not assoc w R - Interim
clpC1 4038878 c.1827A>G synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
clpC1 4038908 c.1797C>G synonymous_variant 0.2 pyrazinamide
clpC1 4038914 c.1791G>C synonymous_variant 0.2 pyrazinamide
clpC1 4038923 c.1780_1782delCTAinsTG frameshift_variant&synonymous_variant 0.2 pyrazinamide
clpC1 4038953 c.1752A>G synonymous_variant 0.22 pyrazinamide
clpC1 4038956 c.1749T>C synonymous_variant 0.22 pyrazinamide
clpC1 4038965 c.1740T>C synonymous_variant 0.22 pyrazinamide
clpC1 4038971 c.1734T>C synonymous_variant 0.19 pyrazinamide
clpC1 4038974 c.1731T>C synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
clpC1 4038989 c.1716T>C synonymous_variant 0.19 pyrazinamide
clpC1 4038997 c.1708T>C synonymous_variant 0.18 pyrazinamide Not assoc w R - Interim
clpC1 4039004 c.1701C>G synonymous_variant 0.19 pyrazinamide
clpC1 4039022 c.1683A>G synonymous_variant 0.17 pyrazinamide
clpC1 4039064 c.1641C>T synonymous_variant 0.15 pyrazinamide
clpC1 4039097 c.1608G>C synonymous_variant 0.14 pyrazinamide
clpC1 4039295 c.1410A>C synonymous_variant 0.13 pyrazinamide
clpC1 4039298 c.1407T>C synonymous_variant 0.14 pyrazinamide
clpC1 4039349 c.1356C>T synonymous_variant 0.16 pyrazinamide
clpC1 4039352 c.1353C>G synonymous_variant 0.16 pyrazinamide
clpC1 4039364 c.1341C>G synonymous_variant 0.14 pyrazinamide
clpC1 4039991 c.714G>A synonymous_variant 1.0 pyrazinamide Not assoc w R
clpC1 4040105 c.600C>G synonymous_variant 0.19 pyrazinamide
clpC1 4040411 c.294T>C synonymous_variant 0.14 pyrazinamide Not assoc w R - Interim
clpC1 4040423 c.282A>G synonymous_variant 0.15 pyrazinamide Not assoc w R - Interim
clpC1 4040426 c.279T>C synonymous_variant 0.16 pyrazinamide
clpC1 4040431 c.274T>C synonymous_variant 0.16 pyrazinamide
clpC1 4040444 c.261C>T synonymous_variant 0.14 pyrazinamide
clpC1 4040450 c.255A>G synonymous_variant 0.15 pyrazinamide Not assoc w R - Interim
clpC1 4040459 c.246C>G synonymous_variant 0.15 pyrazinamide
clpC1 4040465 c.240T>C synonymous_variant 0.14 pyrazinamide
glpK 4138695 p.Pro354Asp missense_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138718 c.1038T>C synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138721 c.1035G>A synonymous_variant 0.18 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4138724 c.1032A>G synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138730 c.1026C>G synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138757 c.999A>G synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138763 c.993G>A synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138769 c.987G>C synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138774 p.Ser328Ala missense_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138778 c.978C>G synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138796 c.960A>G synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138802 c.954G>A synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138808 c.948G>T synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138817 c.939T>C synonymous_variant 0.15 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
embC 4242643 c.2781C>T synonymous_variant 0.99 ethambutol Not assoc w R
embA 4242742 c.-491C>G upstream_gene_variant 0.18 ethambutol
embA 4242748 c.-485A>G upstream_gene_variant 0.16 ethambutol
embA 4242754 c.-479G>C upstream_gene_variant 0.17 ethambutol
embC 4242764 p.Val968Leu missense_variant 0.18 ethambutol
embC 4242779 p.Asn973Asp missense_variant 0.15 ethambutol
embC 4242791 c.2929_2931delGCAinsTC frameshift_variant&missense_variant 0.15 ethambutol
embA 4242796 c.-437G>C upstream_gene_variant 0.15 ethambutol
embA 4242799 c.-434T>C upstream_gene_variant 0.15 ethambutol
embA 4242820 c.-413G>C upstream_gene_variant 0.19 ethambutol
embA 4242823 c.-410G>C upstream_gene_variant 0.19 ethambutol
embB 4247497 c.984T>C synonymous_variant 0.17 ethambutol
embB 4247512 c.999T>C synonymous_variant 0.15 ethambutol
embB 4247539 c.1026T>C synonymous_variant 0.14 ethambutol
embB 4247572 c.1059A>G synonymous_variant 0.14 ethambutol
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 capreomycin
amikacin
kanamycin
gid 4408156 p.Leu16Arg missense_variant 1.0 streptomycin Not assoc w R