Run ID: SRR6045002
Sample name:
Date: 2024-10-04T04:22:48.595174
Number of reads: 76313
Percentage reads mapped: 5.27
Median coverage: 0.0
Strain: lineage4.9
Spoligotype:
Drug-resistance: RR-TB
Lineage | Family | RDs | Frequency |
---|---|---|---|
lineage4 | Euro-American | None | 1.0 |
lineage4.9 | Euro-American (H37Rv-like) | None | 1.0 |
Drug | Resistance | Supporting mutations | WHO confidence | Comment |
---|---|---|---|---|
rifampicin | rpoB | p.Ser441Ala | Assoc w R - Interim | Expert rule: Non-silent variants in RRDR of rpoB |
isoniazid | ||||
ethambutol | ||||
pyrazinamide | ||||
streptomycin | ||||
fluoroquinolones | ||||
moxifloxacin | ||||
ofloxacin | ||||
levofloxacin | ||||
ciprofloxacin | ||||
aminoglycosides | ||||
amikacin | rrs | n.1402C>A | Uncertain significance | Mutation from literature |
n.1484G>T | Assoc w R | |||
capreomycin | rrs | n.1402C>A | Uncertain significance | Mutation from literature |
n.1484G>T | Assoc w R | |||
kanamycin | rrs | n.1402C>A | Uncertain significance | Mutation from literature |
n.1484G>T | Assoc w R | |||
cycloserine | ||||
ethionamide | ||||
clofazimine | ||||
para-aminosalicylic_acid | ||||
delamanid | ||||
bedaquiline | ||||
linezolid |
Gene | Chromosome position | Mutation | Type | Estimated fraction | Drugs | Confidence | Comment |
---|---|---|---|---|---|---|---|
rpoB | 761127 | p.Ser441Ala | missense_variant | 0.75 | rifampicin | Assoc w R - Interim | Expert rule: Non-silent variants in RRDR of rpoB |
rrs | 1473247 | n.1402C>A | non_coding_transcript_exon_variant | 0.93 | amikacin | Uncertain significance | Mutation from literature |
capreomycin | Uncertain significance | Mutation from literature | |||||
kanamycin | Uncertain significance | Mutation from literature | |||||
rrs | 1473329 | n.1484G>T | non_coding_transcript_exon_variant | 0.82 | amikacin | Assoc w R | |
capreomycin | Assoc w R | ||||||
kanamycin | Assoc w R |
Gene | Chromosome position | Mutation | Type | Estimated fraction | Drugs | Confidence |
---|---|---|---|---|---|---|
nusG | 734499 | c.246G>C | synonymous_variant | 1.0 | rifampicin | |
nusG | 734517 | c.264G>A | synonymous_variant | 1.0 | rifampicin | |
nusG | 734532 | c.279A>G | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
nusG | 734541 | c.288A>G | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
nusG | 734559 | c.306T>C | synonymous_variant | 1.0 | rifampicin | |
rpoB | 760316 | c.510C>G | synonymous_variant | 1.0 | rifampicin | |
rpoB | 760328 | c.522G>C | synonymous_variant | 1.0 | rifampicin | |
rpoB | 760331 | c.525G>T | synonymous_variant | 1.0 | rifampicin | |
rpoB | 760337 | c.531C>G | synonymous_variant | 1.0 | rifampicin | |
rpoB | 760340 | c.534G>T | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
rpoB | 761027 | c.1221A>C | synonymous_variant | 0.64 | rifampicin | Not assoc w R - Interim |
rpoB | 761036 | c.1230G>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
rpoB | 761037 | c.1231T>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
rpoB | 761046 | p.Ile414Val | missense_variant | 0.64 | rifampicin | |
rpoB | 761057 | c.1251G>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
rpoB | 761084 | c.1278C>A | synonymous_variant | 0.64 | rifampicin | Not assoc w R - Interim |
rpoB | 761087 | c.1281C>G | synonymous_variant | 0.64 | rifampicin | |
rpoB | 761088 | c.1282_1284delAGCinsTCG | synonymous_variant | 0.64 | rifampicin | |
rpoB | 761097 | c.1291_1293delAGCinsTCG | synonymous_variant | 1.0 | rifampicin | |
rpoB | 761102 | c.1296A>G | synonymous_variant | 1.0 | rifampicin | |
rpoB | 761126 | c.1320G>C | synonymous_variant | 0.75 | rifampicin | |
rpoB | 761132 | c.1326G>T | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
rpoB | 761133 | c.1327T>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
rpoB | 761150 | c.1344A>C | synonymous_variant | 0.86 | rifampicin | Not assoc w R - Interim |
rpoB | 761249 | c.1443A>G | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
rpoC | 762398 | c.-972T>C | upstream_gene_variant | 1.0 | rifampicin | |
rpoB | 762404 | c.2598T>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
rpoC | 762410 | c.-960T>C | upstream_gene_variant | 1.0 | rifampicin | |
rpoB | 762470 | c.2664G>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
rpoB | 762488 | c.2682G>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
rpoC | 763546 | c.177A>G | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
rpoC | 763570 | c.201G>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
rpoC | 763573 | c.204G>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
rpoC | 763594 | c.225C>T | synonymous_variant | 0.57 | rifampicin | Not assoc w R - Interim |
rpoC | 763675 | c.306C>G | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
rpoC | 763708 | c.339G>C | synonymous_variant | 1.0 | rifampicin | |
rpoC | 763726 | c.357C>T | synonymous_variant | 0.58 | rifampicin | |
rpoC | 763732 | c.363C>G | synonymous_variant | 1.0 | rifampicin | |
rpoC | 763744 | c.375G>C | synonymous_variant | 1.0 | rifampicin | |
rpoC | 764491 | c.1122G>C | synonymous_variant | 0.8 | rifampicin | |
rpoC | 764521 | c.1152T>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
rpoC | 764536 | c.1167G>C | synonymous_variant | 0.75 | rifampicin | |
rpoC | 764539 | c.1170C>G | synonymous_variant | 0.75 | rifampicin | Not assoc w R - Interim |
rpoC | 764545 | c.1176C>G | synonymous_variant | 1.0 | rifampicin | |
rpoC | 764549 | p.Pro394Thr | missense_variant | 0.82 | rifampicin | |
rpoC | 764560 | c.1191T>C | synonymous_variant | 0.82 | rifampicin | Not assoc w R - Interim |
rpoC | 764561 | p.Pro398Ala | missense_variant | 0.82 | rifampicin | |
rpoC | 764576 | c.1207_1208delTCinsAG | synonymous_variant | 0.9 | rifampicin | |
rpoC | 764581 | c.1212T>C | synonymous_variant | 0.9 | rifampicin | |
rpoC | 764582 | p.Leu405Met | missense_variant | 0.93 | rifampicin | |
rpoC | 764587 | c.1218C>G | synonymous_variant | 0.89 | rifampicin | |
rpoC | 764611 | c.1242G>C | synonymous_variant | 1.0 | rifampicin | |
rpoC | 764632 | c.1263T>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
rpoC | 764635 | c.1266C>G | synonymous_variant | 0.85 | rifampicin | |
rpoC | 764650 | c.1281G>T | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
rpoC | 764660 | p.Val431Ile | missense_variant | 0.85 | rifampicin | |
rpoC | 764668 | c.1299C>T | synonymous_variant | 0.88 | rifampicin | Not assoc w R - Interim |
rpoC | 764706 | p.Leu446Gln | missense_variant | 0.86 | rifampicin | Uncertain significance |
rpoC | 764740 | p.Met457Ile | missense_variant | 0.78 | rifampicin | |
rpoC | 764746 | c.1377G>C | synonymous_variant | 1.0 | rifampicin | |
rpoC | 764750 | p.Val461Ile | missense_variant | 0.82 | rifampicin | |
rpoC | 764758 | c.1389C>G | synonymous_variant | 0.8 | rifampicin | Not assoc w R - Interim |
rpoC | 764760 | p.Asn464Ser | missense_variant | 0.76 | rifampicin | |
rpoC | 764764 | c.1395T>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
rpoC | 764767 | c.1398G>T | synonymous_variant | 0.76 | rifampicin | |
rpoC | 764780 | p.Ser471Ala | missense_variant | 0.6 | rifampicin | |
rpoC | 764843 | p.Ala492Ser | missense_variant | 0.8 | rifampicin | |
rpoC | 764858 | c.1489T>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
rpoC | 764869 | c.1500C>T | synonymous_variant | 0.73 | rifampicin | Not assoc w R - Interim |
rpoC | 764888 | c.1519_1521delTTGinsCTC | synonymous_variant | 0.8 | rifampicin | |
rpoC | 765409 | c.2040T>G | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
rplC | 800645 | c.-164C>T | upstream_gene_variant | 0.7 | linezolid | |
rplC | 800651 | c.-158G>C | upstream_gene_variant | 0.7 | linezolid | |
rplC | 800654 | c.-155T>C | upstream_gene_variant | 0.91 | linezolid | |
rplC | 800667 | c.-142_-140delTCGinsAGC | upstream_gene_variant | 0.75 | linezolid | |
rplC | 800672 | c.-137G>C | upstream_gene_variant | 0.77 | linezolid | |
rplC | 800693 | c.-116A>G | upstream_gene_variant | 0.92 | linezolid | |
rplC | 800703 | c.-106T>C | upstream_gene_variant | 1.0 | linezolid | |
rplC | 800720 | c.-89T>C | upstream_gene_variant | 1.0 | linezolid | |
rplC | 800723 | c.-86C>G | upstream_gene_variant | 1.0 | linezolid | |
rrs | 1472075 | n.230A>G | non_coding_transcript_exon_variant | 1.0 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | ||||||
amikacin | Uncertain significance | |||||
rrs | 1472102 | n.257G>A | non_coding_transcript_exon_variant | 0.43 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | ||||||
amikacin | Uncertain significance | |||||
rrs | 1472106 | n.261G>A | non_coding_transcript_exon_variant | 1.0 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | Uncertain significance | |||||
amikacin | Not assoc w R | |||||
rrs | 1472108 | n.263C>T | non_coding_transcript_exon_variant | 0.57 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472112 | n.267C>T | non_coding_transcript_exon_variant | 0.4 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472113 | n.268T>C | non_coding_transcript_exon_variant | 0.4 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472120 | n.275G>C | non_coding_transcript_exon_variant | 0.4 | kanamycin | |
capreomycin | ||||||
streptomycin | ||||||
amikacin | ||||||
rrs | 1472122 | n.277G>T | non_coding_transcript_exon_variant | 0.44 | kanamycin | |
capreomycin | ||||||
streptomycin | ||||||
amikacin | ||||||
rrs | 1472150 | n.305T>A | non_coding_transcript_exon_variant | 1.0 | kanamycin | Uncertain significance |
capreomycin | Not assoc w R | |||||
streptomycin | Uncertain significance | |||||
amikacin | Not assoc w R | |||||
rrs | 1472172 | n.327T>C | non_coding_transcript_exon_variant | 0.59 | kanamycin | Uncertain significance |
capreomycin | Not assoc w R | |||||
streptomycin | Uncertain significance | |||||
amikacin | Not assoc w R | |||||
rrs | 1472240 | n.395G>A | non_coding_transcript_exon_variant | 0.5 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472251 | n.406G>A | non_coding_transcript_exon_variant | 0.88 | kanamycin | Uncertain significance |
capreomycin | Not assoc w R | |||||
streptomycin | Uncertain significance | |||||
amikacin | Not assoc w R | |||||
rrs | 1472256 | n.411T>C | non_coding_transcript_exon_variant | 0.5 | kanamycin | |
capreomycin | ||||||
streptomycin | ||||||
amikacin | ||||||
rrs | 1472489 | n.644A>T | non_coding_transcript_exon_variant | 0.39 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472494 | n.649A>G | non_coding_transcript_exon_variant | 0.61 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472496 | n.651T>G | non_coding_transcript_exon_variant | 0.61 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472498 | n.653C>T | non_coding_transcript_exon_variant | 0.61 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472507 | n.662C>A | non_coding_transcript_exon_variant | 0.62 | kanamycin | |
capreomycin | ||||||
streptomycin | ||||||
amikacin | ||||||
rrs | 1472558 | n.713G>A | non_coding_transcript_exon_variant | 0.69 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472569 | n.724G>A | non_coding_transcript_exon_variant | 0.69 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472571 | n.726G>T | non_coding_transcript_exon_variant | 0.65 | kanamycin | |
capreomycin | ||||||
streptomycin | ||||||
amikacin | ||||||
rrs | 1472581 | n.736A>C | non_coding_transcript_exon_variant | 0.65 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472952 | n.1107T>C | non_coding_transcript_exon_variant | 0.91 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472955 | n.1110C>T | non_coding_transcript_exon_variant | 0.91 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472956 | n.1111T>C | non_coding_transcript_exon_variant | 0.91 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472957 | n.1112C>T | non_coding_transcript_exon_variant | 0.91 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472969 | n.1124A>G | non_coding_transcript_exon_variant | 0.91 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472978 | n.1133T>C | non_coding_transcript_exon_variant | 0.91 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1473035 | n.1190G>A | non_coding_transcript_exon_variant | 0.92 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | Uncertain significance | |||||
amikacin | Not assoc w R | |||||
rrs | 1473055 | n.1210C>T | non_coding_transcript_exon_variant | 0.93 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1473056 | n.1211A>T | non_coding_transcript_exon_variant | 0.93 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | Uncertain significance | |||||
amikacin | Not assoc w R | |||||
rrs | 1473066 | n.1221A>G | non_coding_transcript_exon_variant | 0.94 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1473097 | n.1252G>A | non_coding_transcript_exon_variant | 0.95 | kanamycin | |
capreomycin | ||||||
streptomycin | ||||||
amikacin | ||||||
rrs | 1473100 | n.1255G>A | non_coding_transcript_exon_variant | 0.95 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1473104 | n.1259C>T | non_coding_transcript_exon_variant | 1.0 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1473105 | n.1260G>A | non_coding_transcript_exon_variant | 0.95 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | ||||||
amikacin | Uncertain significance | |||||
rrs | 1473110 | n.1265T>G | non_coding_transcript_exon_variant | 1.0 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1473111 | n.1266A>G | non_coding_transcript_exon_variant | 1.0 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1473121 | n.1276T>C | non_coding_transcript_exon_variant | 0.95 | kanamycin | Uncertain significance |
capreomycin | Not assoc w R | |||||
streptomycin | Uncertain significance | |||||
amikacin | Not assoc w R | |||||
rrs | 1473122 | n.1277T>A | non_coding_transcript_exon_variant | 0.95 | kanamycin | Uncertain significance |
capreomycin | Not assoc w R | |||||
streptomycin | Uncertain significance | |||||
amikacin | Not assoc w R | |||||
rrs | 1473145 | n.1300C>T | non_coding_transcript_exon_variant | 0.95 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1473147 | n.1302G>A | non_coding_transcript_exon_variant | 0.95 | kanamycin | Uncertain significance |
capreomycin | ||||||
streptomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1473164 | n.1319C>T | non_coding_transcript_exon_variant | 0.93 | kanamycin | |
capreomycin | ||||||
streptomycin | Uncertain significance | |||||
amikacin | ||||||
rrs | 1473166 | n.1321G>A | non_coding_transcript_exon_variant | 0.93 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1473276 | n.1431A>G | non_coding_transcript_exon_variant | 1.0 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1473283 | n.1438T>C | non_coding_transcript_exon_variant | 0.89 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | ||||||
amikacin | Uncertain significance | |||||
rrs | 1473290 | n.1445C>T | non_coding_transcript_exon_variant | 1.0 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | ||||||
amikacin | Uncertain significance | |||||
rrs | 1473291 | n.1446_1447insT | non_coding_transcript_exon_variant | 0.87 | kanamycin | |
capreomycin | ||||||
streptomycin | ||||||
amikacin | ||||||
rrs | 1473301 | n.1456T>C | non_coding_transcript_exon_variant | 1.0 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1473319 | n.1474C>T | non_coding_transcript_exon_variant | 0.83 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1473324 | n.1479G>A | non_coding_transcript_exon_variant | 0.83 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | ||||||
amikacin | ||||||
rrl | 1474488 | n.831G>T | non_coding_transcript_exon_variant | 0.9 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474496 | n.839C>A | non_coding_transcript_exon_variant | 0.9 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474497 | n.840G>C | non_coding_transcript_exon_variant | 0.9 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474506 | n.849C>G | non_coding_transcript_exon_variant | 0.9 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474507 | n.850G>T | non_coding_transcript_exon_variant | 0.9 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474516 | n.859C>A | non_coding_transcript_exon_variant | 0.75 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474537 | n.880G>A | non_coding_transcript_exon_variant | 0.75 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474558 | n.901G>A | non_coding_transcript_exon_variant | 0.7 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1474583 | n.926C>T | non_coding_transcript_exon_variant | 0.7 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474601 | n.944C>T | non_coding_transcript_exon_variant | 0.73 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474632 | n.975G>T | non_coding_transcript_exon_variant | 1.0 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474636 | n.979A>T | non_coding_transcript_exon_variant | 1.0 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1474637 | n.980C>T | non_coding_transcript_exon_variant | 1.0 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1474638 | n.981C>G | non_coding_transcript_exon_variant | 1.0 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474639 | n.982G>C | non_coding_transcript_exon_variant | 1.0 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474673 | n.1016T>C | non_coding_transcript_exon_variant | 1.0 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474675 | n.1018C>A | non_coding_transcript_exon_variant | 0.47 | capreomycin | |
linezolid | ||||||
rrl | 1474676 | n.1019T>A | non_coding_transcript_exon_variant | 1.0 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474677 | n.1020A>G | non_coding_transcript_exon_variant | 0.5 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474794 | n.1137C>T | non_coding_transcript_exon_variant | 1.0 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474800 | n.1143T>C | non_coding_transcript_exon_variant | 0.67 | capreomycin | |
linezolid | ||||||
rrl | 1474823 | n.1166C>G | non_coding_transcript_exon_variant | 0.69 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474827 | n.1170C>T | non_coding_transcript_exon_variant | 0.69 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1475692 | n.2035G>C | non_coding_transcript_exon_variant | 0.9 | capreomycin | |
linezolid | ||||||
rrl | 1475751 | n.2094C>A | non_coding_transcript_exon_variant | 0.72 | capreomycin | |
linezolid | ||||||
rrl | 1475752 | n.2095C>G | non_coding_transcript_exon_variant | 0.72 | capreomycin | |
linezolid | ||||||
rrl | 1475753 | n.2096C>G | non_coding_transcript_exon_variant | 0.72 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1475758 | n.2101_2107delACCCGCAinsGCT | non_coding_transcript_exon_variant | 1.0 | capreomycin | |
linezolid | ||||||
rrl | 1475765 | n.2108_2112delAGGGTinsTCGGC | non_coding_transcript_exon_variant | 1.0 | capreomycin | |
linezolid | ||||||
rrl | 1475775 | n.2118G>T | non_coding_transcript_exon_variant | 0.68 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1475776 | n.2119G>C | non_coding_transcript_exon_variant | 0.68 | capreomycin | |
linezolid | ||||||
rrl | 1475881 | n.2224T>C | non_coding_transcript_exon_variant | 0.67 | capreomycin | |
linezolid | ||||||
rrl | 1475884 | n.2227A>G | non_coding_transcript_exon_variant | 0.67 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1475896 | n.2239A>G | non_coding_transcript_exon_variant | 0.67 | capreomycin | |
linezolid | ||||||
rrl | 1475897 | n.2240T>C | non_coding_transcript_exon_variant | 0.67 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1475898 | n.2241A>G | non_coding_transcript_exon_variant | 0.67 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1475899 | n.2242G>A | non_coding_transcript_exon_variant | 0.7 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1475943 | n.2286G>A | non_coding_transcript_exon_variant | 0.65 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1475952 | n.2295A>G | non_coding_transcript_exon_variant | 0.65 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1475963 | n.2306G>T | non_coding_transcript_exon_variant | 0.62 | capreomycin | |
linezolid | ||||||
rrl | 1475970 | n.2313C>T | non_coding_transcript_exon_variant | 0.56 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1475975 | n.2318C>T | non_coding_transcript_exon_variant | 1.0 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1475977 | n.2320A>G | non_coding_transcript_exon_variant | 1.0 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1475978 | n.2321C>T | non_coding_transcript_exon_variant | 0.57 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1475988 | n.2331A>G | non_coding_transcript_exon_variant | 1.0 | capreomycin | Not assoc w R |
linezolid | Uncertain significance | |||||
rrl | 1475997 | n.2340A>G | non_coding_transcript_exon_variant | 0.54 | capreomycin | |
linezolid | ||||||
rrl | 1475998 | n.2341C>T | non_coding_transcript_exon_variant | 0.5 | capreomycin | |
linezolid | Uncertain significance | |||||
rrl | 1476001 | n.2344T>C | non_coding_transcript_exon_variant | 0.5 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476131 | n.2474C>T | non_coding_transcript_exon_variant | 1.0 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476160 | n.2503T>C | non_coding_transcript_exon_variant | 0.6 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476165 | n.2508T>A | non_coding_transcript_exon_variant | 0.6 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476200 | n.2543A>T | non_coding_transcript_exon_variant | 0.5 | capreomycin | Not assoc w R |
linezolid | Uncertain significance | |||||
rrl | 1476201 | n.2544C>T | non_coding_transcript_exon_variant | 0.5 | capreomycin | Not assoc w R |
linezolid | Uncertain significance | |||||
rrl | 1476214 | n.2557G>T | non_coding_transcript_exon_variant | 1.0 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476215 | n.2558C>T | non_coding_transcript_exon_variant | 0.4 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476221 | n.2564T>C | non_coding_transcript_exon_variant | 0.32 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476224 | n.2567A>G | non_coding_transcript_exon_variant | 1.0 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476245 | n.2588C>T | non_coding_transcript_exon_variant | 0.74 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476252 | n.2595T>G | non_coding_transcript_exon_variant | 1.0 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476260 | n.2603A>G | non_coding_transcript_exon_variant | 0.76 | capreomycin | Not assoc w R |
linezolid | Uncertain significance | |||||
rrl | 1476281 | n.2624T>C | non_coding_transcript_exon_variant | 1.0 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476295 | n.2638C>G | non_coding_transcript_exon_variant | 0.74 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476296 | n.2639C>T | non_coding_transcript_exon_variant | 0.72 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476297 | n.2640C>G | non_coding_transcript_exon_variant | 0.72 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476298 | n.2641C>G | non_coding_transcript_exon_variant | 0.72 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476300 | n.2643G>T | non_coding_transcript_exon_variant | 0.7 | capreomycin | |
linezolid | ||||||
rrl | 1476301 | n.2644A>T | non_coding_transcript_exon_variant | 0.72 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476309 | n.2652G>C | non_coding_transcript_exon_variant | 0.71 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476311 | n.2654G>C | non_coding_transcript_exon_variant | 0.71 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476337 | n.2680C>T | non_coding_transcript_exon_variant | 0.76 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476359 | n.2702C>G | non_coding_transcript_exon_variant | 0.84 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476381 | n.2724G>C | non_coding_transcript_exon_variant | 0.82 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476428 | n.2771C>T | non_coding_transcript_exon_variant | 0.81 | capreomycin | Not assoc w R |
linezolid | Uncertain significance | |||||
rrl | 1476466 | n.2809C>T | non_coding_transcript_exon_variant | 0.81 | capreomycin | Not assoc w R |
linezolid | Uncertain significance | |||||
rrl | 1476506 | n.2849T>C | non_coding_transcript_exon_variant | 0.65 | capreomycin | Not assoc w R |
linezolid | Uncertain significance | |||||
rrl | 1476515 | n.2858C>T | non_coding_transcript_exon_variant | 0.5 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1476583 | n.2926G>A | non_coding_transcript_exon_variant | 0.65 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1476597 | n.2940G>A | non_coding_transcript_exon_variant | 0.67 | capreomycin | Uncertain significance |
linezolid | ||||||
rpsA | 1833949 | c.408T>C | synonymous_variant | 1.0 | pyrazinamide | |
rpsA | 1833970 | c.429G>C | synonymous_variant | 1.0 | pyrazinamide | |
rpsA | 1833979 | c.438T>C | synonymous_variant | 1.0 | pyrazinamide | |
rpsA | 1833991 | c.450C>G | synonymous_variant | 1.0 | pyrazinamide | |
rpsA | 1834009 | c.468C>A | synonymous_variant | 0.54 | pyrazinamide | Not assoc w R - Interim |
rpsA | 1834012 | c.471G>C | synonymous_variant | 1.0 | pyrazinamide | |
rpsA | 1834015 | c.474G>C | synonymous_variant | 1.0 | pyrazinamide | |
rpsA | 1834021 | c.480C>T | synonymous_variant | 0.54 | pyrazinamide | |
rpsA | 1834030 | c.489C>G | synonymous_variant | 1.0 | pyrazinamide | |
rpsA | 1834222 | c.681T>C | synonymous_variant | 0.75 | pyrazinamide | |
rpsA | 1834225 | c.684C>G | synonymous_variant | 0.75 | pyrazinamide | |
rpsA | 1834231 | c.690T>C | synonymous_variant | 1.0 | pyrazinamide | |
rpsA | 1834240 | c.699T>C | synonymous_variant | 1.0 | pyrazinamide | |
rpsA | 1834243 | c.702G>C | synonymous_variant | 0.75 | pyrazinamide | |
rpsA | 1834249 | c.708T>C | synonymous_variant | 1.0 | pyrazinamide | |
rpsA | 1834261 | c.720A>G | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
rpsA | 1834283 | p.Pro248Ala | missense_variant | 0.69 | pyrazinamide | |
rpsA | 1834294 | c.753G>C | synonymous_variant | 0.64 | pyrazinamide | |
rpsA | 1834298 | p.Gln253Glu | missense_variant | 0.6 | pyrazinamide | |
rpsA | 1834306 | c.765T>C | synonymous_variant | 1.0 | pyrazinamide | |
rpsA | 1834307 | p.Asp256Gln | missense_variant | 0.6 | pyrazinamide | |
rpsA | 1834325 | p.Val262Ile | missense_variant | 0.62 | pyrazinamide | |
rpsA | 1834333 | p.Asp264Glu | missense_variant | 0.6 | pyrazinamide | |
rpsA | 1834340 | p.Met267Leu | missense_variant | 0.56 | pyrazinamide | Uncertain significance |
rpsA | 1834348 | c.807T>C | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
rpsA | 1834366 | c.825A>G | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
rpsA | 1834411 | c.870T>C | synonymous_variant | 1.0 | pyrazinamide | |
rpsA | 1834417 | c.876G>C | synonymous_variant | 0.44 | pyrazinamide | |
rpsA | 1834423 | c.882G>T | synonymous_variant | 1.0 | pyrazinamide | |
rpsA | 1834427 | p.Ile296Val | missense_variant | 0.56 | pyrazinamide | Uncertain significance |
rpsA | 1834431 | p.Val297Ala | missense_variant | 0.56 | pyrazinamide | Uncertain significance |
rpsA | 1834447 | c.906C>G | synonymous_variant | 0.62 | pyrazinamide | |
rpsA | 1834451 | c.910T>C | synonymous_variant | 1.0 | pyrazinamide | |
rpsA | 1834456 | c.915T>G | synonymous_variant | 0.41 | pyrazinamide | |
rpsA | 1834468 | c.927A>G | synonymous_variant | 1.0 | pyrazinamide | |
rpsA | 1834477 | c.936C>T | synonymous_variant | 0.56 | pyrazinamide | Not assoc w R - Interim |
rpsA | 1834489 | c.948T>C | synonymous_variant | 1.0 | pyrazinamide | |
rpoA | 3877848 | c.660C>T | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
rpoA | 3877857 | c.651G>A | synonymous_variant | 1.0 | rifampicin | |
rpoA | 3877866 | c.642G>A | synonymous_variant | 1.0 | rifampicin | |
rpoA | 3877875 | c.633T>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
rpoA | 3877887 | c.621G>C | synonymous_variant | 1.0 | rifampicin | |
rpoA | 3877893 | c.615C>T | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
rpoA | 3878295 | c.213A>G | synonymous_variant | 0.8 | rifampicin | |
rpoA | 3878298 | c.210A>G | synonymous_variant | 0.8 | rifampicin | Not assoc w R - Interim |
rpoA | 3878304 | c.204G>T | synonymous_variant | 1.0 | rifampicin | |
rpoA | 3878310 | c.198G>T | synonymous_variant | 0.8 | rifampicin | Not assoc w R - Interim |
rpoA | 3878317 | p.Thr64Ser | missense_variant | 0.8 | rifampicin | |
rpoA | 3878322 | c.186A>G | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
clpC1 | 4038812 | c.1893T>C | synonymous_variant | 1.0 | pyrazinamide | |
clpC1 | 4038815 | c.1890G>C | synonymous_variant | 1.0 | pyrazinamide | |
clpC1 | 4040024 | c.681A>G | synonymous_variant | 1.0 | pyrazinamide | |
clpC1 | 4040027 | c.678C>G | synonymous_variant | 1.0 | pyrazinamide | |
clpC1 | 4040033 | c.672G>C | synonymous_variant | 1.0 | pyrazinamide | |
clpC1 | 4040069 | c.636G>C | synonymous_variant | 1.0 | pyrazinamide |