TB-Profiler result

Run: ERR4818583
Summary

Run ID: ERR4818583

Sample name:

Date: 2024-04-14T23:53:35.362040

Number of reads: 1913692

Percentage reads mapped: 72.5

Median coverage: 56.0

Strain: lineage4.3.3

Spoligotype:

Drug-resistance: Other

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage4.3 Euro-American (LAM) None 1.0
lineage4 Euro-American None 1.0
lineage4.3.3 Euro-American (LAM) RD115 1.0
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin rrs n.1402C>A Uncertain significance Mutation from literature
n.1484G>T Assoc w R
capreomycin rrs n.1402C>A Uncertain significance Mutation from literature
n.1484G>T Assoc w R
kanamycin rrs n.1402C>A Uncertain significance Mutation from literature
n.1484G>T Assoc w R
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
rrs 1473247 n.1402C>A non_coding_transcript_exon_variant 0.52 amikacin Uncertain significance Mutation from literature
capreomycin Uncertain significance Mutation from literature
kanamycin Uncertain significance Mutation from literature
rrs 1473329 n.1484G>T non_coding_transcript_exon_variant 0.35 capreomycin Assoc w R
amikacin Assoc w R
kanamycin Assoc w R
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 8040 p.Gly247Ser missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
hadA 731988 p.Val20Ala missense_variant 1.0 isoniazid Uncertain significance
rpoB 761786 c.1980C>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>C synonymous_variant 0.11 rifampicin Not assoc w R - Interim
rpoB 762083 c.2277T>G synonymous_variant 0.14 rifampicin
rpoB 762084 c.2278_2280delGCGinsCT frameshift_variant&missense_variant 0.14 rifampicin
rpoB 762100 p.Arg765His missense_variant 0.18 rifampicin
rpoB 762114 p.Ile770Val missense_variant 0.25 rifampicin Uncertain significance
rpoB 762125 p.Glu773Asp missense_variant 0.25 rifampicin
rpoB 762126 p.Val774Met missense_variant 0.24 rifampicin
rpoB 762129 p.Leu775Ile missense_variant 0.25 rifampicin
rpoB 762135 p.Asp777Ser missense_variant 0.24 rifampicin
rpoB 762140 c.2334G>T synonymous_variant 0.24 rifampicin
rpoB 762143 c.2337T>C synonymous_variant 0.23 rifampicin
rpoB 762146 p.Glu780Asp missense_variant 0.24 rifampicin
rpoB 762149 c.2343G>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 762167 c.2361T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 762176 c.2370T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 762180 p.Asp792Pro missense_variant 0.23 rifampicin
rpoB 762185 c.2379G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 762209 c.2403C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 762212 c.2406G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 762218 c.2412T>C synonymous_variant 0.22 rifampicin
rpoB 762230 c.2424G>C synonymous_variant 0.2 rifampicin
rpoB 762233 c.2427G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 762236 c.2430G>T synonymous_variant 0.2 rifampicin
rpoB 762245 c.2439G>A synonymous_variant 0.15 rifampicin
rpoB 762254 c.2448T>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 762257 c.2451C>G synonymous_variant 0.12 rifampicin
rpoB 762266 c.2460T>C synonymous_variant 0.12 rifampicin
rpoC 763528 c.159G>C synonymous_variant 0.17 rifampicin
rpoC 763531 c.162G>C synonymous_variant 0.18 rifampicin Not assoc w R
rpoC 763534 c.165T>C synonymous_variant 0.17 rifampicin
rpoC 763537 c.168C>T synonymous_variant 0.18 rifampicin
rpoC 763546 c.177A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 763550 p.Tyr61Ala missense_variant 0.2 rifampicin
rpoC 763570 c.201G>T synonymous_variant 0.2 rifampicin
rpoC 763573 c.204G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 763589 c.220_222delATCinsGG frameshift_variant&missense_variant 0.22 rifampicin
rpoC 763615 c.246G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 763618 c.249C>A synonymous_variant 0.16 rifampicin
rpoC 763621 c.252C>G synonymous_variant 0.16 rifampicin
rpoC 763622 p.Ala85Ser missense_variant 0.16 rifampicin Uncertain significance
rpoC 763627 p.Lys86Asn missense_variant 0.19 rifampicin Uncertain significance
rpoC 763633 c.264T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 763642 c.273G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 763660 c.291T>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 763666 c.297G>A synonymous_variant 0.22 rifampicin
rpoC 763669 c.300C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 763702 c.333C>G synonymous_variant 0.1 rifampicin Not assoc w R - Interim
rpoC 763704 p.Ser112Cys missense_variant 0.1 rifampicin
rpoC 763714 c.345G>C synonymous_variant 0.1 rifampicin Not assoc w R - Interim
rpoC 763723 c.354G>C synonymous_variant 0.11 rifampicin
rpoC 763727 c.358_360delCTGinsAT frameshift_variant&missense_variant 0.11 rifampicin
rpoC 763732 c.363C>G synonymous_variant 0.11 rifampicin
rpoC 763744 c.375G>C synonymous_variant 0.11 rifampicin
rpoC 763751 p.Ile128Val missense_variant 0.11 rifampicin
rpoC 764365 c.996C>T synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764371 c.1002G>T synonymous_variant 0.25 rifampicin
rpoC 764377 c.1008C>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 764380 c.1011G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 764387 c.1018_1020delTTGinsCC frameshift_variant&missense_variant 0.26 rifampicin
rpoC 764404 c.1035C>T synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764405 c.1036_1038delAGGinsCC frameshift_variant&missense_variant 0.27 rifampicin
rpoC 764425 c.1056C>T synonymous_variant 0.27 rifampicin
rpoC 764428 c.1059G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 764431 c.1062G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 764434 c.1065A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 764441 c.1072_1074delATCinsCT frameshift_variant&missense_variant 0.25 rifampicin
rpoC 764446 c.1077T>C synonymous_variant 0.25 rifampicin
rpoC 764449 c.1080G>C synonymous_variant 0.26 rifampicin
rpoC 764458 c.1089G>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 764461 c.1092A>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 764497 c.1128A>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 764498 p.Ser377Ala missense_variant 0.32 rifampicin
rpoC 764503 c.1134G>C synonymous_variant 0.34 rifampicin
rpoC 764506 c.1137C>T synonymous_variant 0.36 rifampicin
rpoC 764507 p.Ala380Ser missense_variant 0.36 rifampicin
rpoC 764521 c.1152T>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 764527 c.1158C>T synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 764536 c.1167G>T synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 764539 c.1170C>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 764542 c.1173C>G synonymous_variant 0.34 rifampicin
rpoC 764548 c.1179G>T synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 764557 c.1188C>T synonymous_variant 0.39 rifampicin
rpoC 764560 c.1191T>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 764572 c.1203G>A synonymous_variant 0.43 rifampicin
rpoC 764575 c.1206T>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 764581 c.1212T>C synonymous_variant 0.37 rifampicin
rpoC 764582 p.Leu405Met missense_variant 0.37 rifampicin
rpoC 764611 c.1242G>T synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764632 c.1263T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 764668 c.1299C>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764677 c.1308C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764681 p.Leu438Met missense_variant 0.2 rifampicin
rpoC 764692 c.1323C>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 764695 c.1326T>C synonymous_variant 0.15 rifampicin
rpoC 764706 p.Leu446Gln missense_variant 0.14 rifampicin Uncertain significance
rpoC 764713 c.1344G>A synonymous_variant 0.15 rifampicin
rpoC 764731 c.1362G>C synonymous_variant 0.12 rifampicin
rpoC 764737 c.1368G>C synonymous_variant 0.14 rifampicin
rpoC 764746 c.1377G>C synonymous_variant 0.14 rifampicin
rpoC 764751 p.Val461Asp missense_variant 0.14 rifampicin
rpoC 764762 c.1393_1395delCATinsTC frameshift_variant&missense_variant 0.12 rifampicin
rpoC 764769 p.Gln467Pro missense_variant 0.12 rifampicin
rpoC 764995 c.1626C>G synonymous_variant 1.0 rifampicin Not assoc w R
mmpL5 775639 p.Ile948Val missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
Rv1129c 1253304 p.Asn411Tyr missense_variant 1.0 moxifloxacin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472106 n.261G>A non_coding_transcript_exon_variant 0.37 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.38 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472122 n.277G>A non_coding_transcript_exon_variant 0.47 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472123 n.278A>G non_coding_transcript_exon_variant 0.51 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472150 n.305T>A non_coding_transcript_exon_variant 0.49 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472160 n.315C>T non_coding_transcript_exon_variant 0.51 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472225 n.380C>T non_coding_transcript_exon_variant 0.32 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472240 n.395G>A non_coding_transcript_exon_variant 0.6 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472251 n.406G>C non_coding_transcript_exon_variant 0.57 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472279 n.434T>G non_coding_transcript_exon_variant 0.41 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472297 n.453_465delGTCCGGGTTCTCT non_coding_transcript_exon_variant 0.45 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472313 n.468delGinsCA non_coding_transcript_exon_variant 0.45 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472315 n.470T>G non_coding_transcript_exon_variant 0.46 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472325 n.480G>T non_coding_transcript_exon_variant 0.52 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472326 n.481T>G non_coding_transcript_exon_variant 0.52 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472344 n.499C>T non_coding_transcript_exon_variant 0.56 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472368 n.523A>G non_coding_transcript_exon_variant 0.59 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472400 n.555C>T non_coding_transcript_exon_variant 0.33 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472557 n.712G>A non_coding_transcript_exon_variant 0.45 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472571 n.726G>T non_coding_transcript_exon_variant 0.49 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472579 n.734G>A non_coding_transcript_exon_variant 0.51 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472582 n.737G>T non_coding_transcript_exon_variant 0.51 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472584 n.739A>T non_coding_transcript_exon_variant 0.51 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472585 n.740A>C non_coding_transcript_exon_variant 0.51 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472597 n.752G>A non_coding_transcript_exon_variant 0.57 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472616 n.771G>A non_coding_transcript_exon_variant 0.61 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472623 n.778A>C non_coding_transcript_exon_variant 0.57 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472674 n.829_838delTTCCTTCCTTinsCCCTTCCAC non_coding_transcript_exon_variant 0.74 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472687 n.842A>G non_coding_transcript_exon_variant 0.75 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472767 n.922G>C non_coding_transcript_exon_variant 0.7 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472790 n.945T>C non_coding_transcript_exon_variant 0.71 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472837 n.992C>T non_coding_transcript_exon_variant 0.54 streptomycin Uncertain significance
kanamycin
capreomycin
amikacin
rrs 1472840 n.995A>T non_coding_transcript_exon_variant 0.53 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472844 n.999C>A non_coding_transcript_exon_variant 0.53 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472849 n.1004C>T non_coding_transcript_exon_variant 0.47 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472850 n.1005T>C non_coding_transcript_exon_variant 0.5 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472857 n.1012A>G non_coding_transcript_exon_variant 0.55 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472863 n.1018T>G non_coding_transcript_exon_variant 0.53 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472866 n.1021C>T non_coding_transcript_exon_variant 0.55 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472869 n.1024G>T non_coding_transcript_exon_variant 0.57 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472874 n.1029C>T non_coding_transcript_exon_variant 0.62 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472875 n.1030T>G non_coding_transcript_exon_variant 0.59 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472878 n.1033G>A non_coding_transcript_exon_variant 0.53 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472879 n.1034T>C non_coding_transcript_exon_variant 0.53 streptomycin Uncertain significance
kanamycin
capreomycin
amikacin
rrs 1472880 n.1035G>A non_coding_transcript_exon_variant 0.52 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472952 n.1107T>C non_coding_transcript_exon_variant 0.53 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472956 n.1111T>C non_coding_transcript_exon_variant 0.56 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472957 n.1112C>A non_coding_transcript_exon_variant 0.56 streptomycin Uncertain significance
kanamycin
capreomycin Uncertain significance
amikacin
rrs 1472969 n.1125delC non_coding_transcript_exon_variant 0.53 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472973 n.1128A>T non_coding_transcript_exon_variant 0.52 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472974 n.1129A>C non_coding_transcript_exon_variant 0.52 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472975 n.1130T>G non_coding_transcript_exon_variant 0.52 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472977 n.1132G>C non_coding_transcript_exon_variant 0.53 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472987 n.1142G>A non_coding_transcript_exon_variant 0.56 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472989 n.1144G>T non_coding_transcript_exon_variant 0.56 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472990 n.1145A>G non_coding_transcript_exon_variant 0.56 streptomycin Uncertain significance
kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472996 n.1151T>C non_coding_transcript_exon_variant 0.55 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473004 n.1159T>C non_coding_transcript_exon_variant 0.53 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473029 n.1184C>G non_coding_transcript_exon_variant 0.59 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473066 n.1221A>G non_coding_transcript_exon_variant 0.6 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473091 n.1246G>A non_coding_transcript_exon_variant 0.53 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473093 n.1248C>T non_coding_transcript_exon_variant 0.52 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473099 n.1254T>G non_coding_transcript_exon_variant 0.5 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473100 n.1255G>C non_coding_transcript_exon_variant 0.5 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473102 n.1257C>T non_coding_transcript_exon_variant 0.5 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473104 n.1259C>T non_coding_transcript_exon_variant 0.5 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473109 n.1264T>G non_coding_transcript_exon_variant 0.5 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473111 n.1266A>G non_coding_transcript_exon_variant 0.5 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473120 n.1275C>T non_coding_transcript_exon_variant 0.48 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473121 n.1276T>C non_coding_transcript_exon_variant 0.49 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1473122 n.1277T>A non_coding_transcript_exon_variant 0.49 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1473123 n.1278A>G non_coding_transcript_exon_variant 0.49 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.65 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.59 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473226 n.1381C>G non_coding_transcript_exon_variant 0.58 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473276 n.1431A>G non_coding_transcript_exon_variant 0.45 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473283 n.1438T>C non_coding_transcript_exon_variant 0.42 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473288 n.1443C>T non_coding_transcript_exon_variant 0.39 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473290 n.1445C>T non_coding_transcript_exon_variant 0.38 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473291 n.1446G>T non_coding_transcript_exon_variant 0.38 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473294 n.1449A>G non_coding_transcript_exon_variant 0.38 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473301 n.1456T>C non_coding_transcript_exon_variant 0.4 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473315 n.1470T>C non_coding_transcript_exon_variant 0.37 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473316 n.1471C>T non_coding_transcript_exon_variant 0.37 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473319 n.1474C>T non_coding_transcript_exon_variant 0.37 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473324 n.1479G>A non_coding_transcript_exon_variant 0.37 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin
rrl 1474201 n.544T>C non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474202 n.545T>A non_coding_transcript_exon_variant 0.4 capreomycin
linezolid
rrl 1474218 n.561T>A non_coding_transcript_exon_variant 0.56 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 0.52 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474476 n.819C>T non_coding_transcript_exon_variant 0.45 capreomycin
linezolid
rrl 1474496 n.839C>A non_coding_transcript_exon_variant 0.48 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474497 n.840G>C non_coding_transcript_exon_variant 0.48 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474506 n.849C>G non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474507 n.850G>T non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474527 n.870T>C non_coding_transcript_exon_variant 0.37 capreomycin
linezolid
rrl 1474528 n.871T>A non_coding_transcript_exon_variant 0.37 capreomycin
linezolid
rrl 1474529 n.872A>G non_coding_transcript_exon_variant 0.37 capreomycin
linezolid
rrl 1474535 n.878A>C non_coding_transcript_exon_variant 0.37 capreomycin
linezolid
rrl 1474537 n.880G>A non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474540 n.883T>C non_coding_transcript_exon_variant 0.38 capreomycin
linezolid
rrl 1474541 n.884G>T non_coding_transcript_exon_variant 0.38 capreomycin
linezolid
rrl 1474542 n.885A>G non_coding_transcript_exon_variant 0.38 capreomycin
linezolid
rrl 1474558 n.901G>A non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid
rrl 1474582 n.925T>A non_coding_transcript_exon_variant 0.38 capreomycin
linezolid
rrl 1476141 n.2484A>G non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476153 n.2496T>C non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476160 n.2503T>C non_coding_transcript_exon_variant 0.53 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476165 n.2508T>G non_coding_transcript_exon_variant 0.53 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476194 n.2537A>G non_coding_transcript_exon_variant 0.57 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476200 n.2543A>T non_coding_transcript_exon_variant 0.57 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476201 n.2544C>T non_coding_transcript_exon_variant 0.53 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476204 n.2547C>T non_coding_transcript_exon_variant 0.53 capreomycin
linezolid
rrl 1476214 n.2557G>T non_coding_transcript_exon_variant 0.62 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476215 n.2558C>T non_coding_transcript_exon_variant 0.62 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.53 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476245 n.2588C>T non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476251 n.2594T>A non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476252 n.2595T>G non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476256 n.2599A>T non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476260 n.2603A>G non_coding_transcript_exon_variant 0.33 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476359 n.2702C>T non_coding_transcript_exon_variant 0.44 capreomycin
linezolid
rrl 1476363 n.2706A>G non_coding_transcript_exon_variant 0.42 capreomycin
linezolid
rrl 1476366 n.2709A>C non_coding_transcript_exon_variant 0.42 capreomycin
linezolid
rrl 1476368 n.2711T>C non_coding_transcript_exon_variant 0.48 capreomycin Uncertain significance
linezolid
rrl 1476369 n.2712C>T non_coding_transcript_exon_variant 0.48 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476372 n.2715T>C non_coding_transcript_exon_variant 0.48 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476374 n.2717T>G non_coding_transcript_exon_variant 0.48 capreomycin
linezolid
rrl 1476381 n.2724G>A non_coding_transcript_exon_variant 0.56 capreomycin
linezolid
rrl 1476428 n.2771C>T non_coding_transcript_exon_variant 0.5 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476429 n.2772A>C non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476481 n.2824T>A non_coding_transcript_exon_variant 0.41 capreomycin
linezolid
rpsA 1833886 c.345C>G synonymous_variant 0.12 pyrazinamide
rpsA 1833893 p.Ala118Lys missense_variant 0.12 pyrazinamide
rpsA 1833896 p.Leu119Ile missense_variant 0.13 pyrazinamide
rpsA 1833905 p.Lys122Glu missense_variant 0.13 pyrazinamide
rpsA 1833912 p.Glu124Gly missense_variant 0.13 pyrazinamide
rpsA 1833915 p.Ala125Val missense_variant 0.13 pyrazinamide Uncertain significance
rpsA 1833921 p.Lys127Thr missense_variant 0.13 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.14 pyrazinamide
rpsA 1833940 c.399C>T synonymous_variant 0.15 pyrazinamide
rpsA 1834451 c.910T>C synonymous_variant 0.11 pyrazinamide
rpsA 1834459 c.918G>C synonymous_variant 0.11 pyrazinamide
rpsA 1834465 c.924T>C synonymous_variant 0.11 pyrazinamide
rpsA 1834489 c.948T>C synonymous_variant 0.11 pyrazinamide
rpsA 1834508 p.Ile323Val missense_variant 0.1 pyrazinamide
rpsA 1834528 c.987T>C synonymous_variant 0.12 pyrazinamide
rpsA 1834534 c.993C>G synonymous_variant 0.12 pyrazinamide
rpsA 1834538 c.997_999delGTGinsAC frameshift_variant&missense_variant 0.12 pyrazinamide Uncertain significance
rpsA 1834546 p.Asp335Glu missense_variant 0.12 pyrazinamide
rpsA 1834552 c.1011G>C synonymous_variant 0.11 pyrazinamide
rpsA 1834555 c.1014T>C synonymous_variant 0.11 pyrazinamide
rpsA 1834556 p.Ala339Ser missense_variant 0.11 pyrazinamide
rpsA 1834836 p.Met432Thr missense_variant 1.0 pyrazinamide Not assoc w R - Interim
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
kasA 2518919 p.Gly269Ser missense_variant 1.0 isoniazid
Rv2477c 2783478 p.His189Tyr missense_variant 1.0 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
kanamycin Uncertain significance
rifampicin Uncertain significance
amikacin Uncertain significance
Rv2681 2997808 p.Ala357Val missense_variant 1.0 capreomycin
Rv2752c 3067135 c.-944C>T upstream_gene_variant 1.0 ethambutol Uncertain significance
moxifloxacin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
thyA 3073868 p.Thr202Ala missense_variant 1.0 para-aminosalicylic_acid
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
mtrB 3625065 p.Met517Leu missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
clpC1 4038287 c.2418C>T synonymous_variant 1.0 pyrazinamide Not assoc w R
embC 4241111 p.Val417Met missense_variant 1.0 ethambutol Uncertain significance
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 capreomycin
amikacin
kanamycin
gid 4407720 c.483C>G synonymous_variant 1.0 streptomycin Not assoc w R - Interim
gid 4408156 p.Leu16Arg missense_variant 1.0 streptomycin Not assoc w R