TB-Profiler result

Run: SAMN02585910
Summary

Run ID: SAMN02585910

Sample name:

Date: 2024-10-04T23:25:46.835708

Number of reads: 13051523

Percentage reads mapped: 73.41

Median coverage: 291.0

Strain: lineage2.2.1

Spoligotype:

Drug-resistance: Other

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage2 East-Asian RD105 0.98
lineage2.2.1 East-Asian (Beijing) RD105;RD207;RD181 0.98
lineage2.2 East-Asian (Beijing) RD105;RD207 0.99
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol embB p.His312Arg Mutation from literature
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
embB 4247448 p.His312Arg missense_variant 0.24 ethambutol Mutation from literature
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
dnaA 1092 c.1092T>C synonymous_variant 0.17 isoniazid Not assoc w R - Interim
dnaA 1245 c.1245G>C synonymous_variant 0.19 isoniazid Not assoc w R - Interim
dnaA 1254 c.1254T>C synonymous_variant 0.2 isoniazid
dnaA 1278 c.1278T>C synonymous_variant 0.18 isoniazid
gyrB 6145 c.906C>T synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrB 6250 c.1011A>G synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6259 p.Asp340Glu missense_variant 0.19 levofloxacin
moxifloxacin
gyrB 6286 c.1047T>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrB 6307 c.1068T>G synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6331 c.-971A>G upstream_gene_variant 0.17 levofloxacin
moxifloxacin
gyrB 7060 c.1821T>C synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 7093 c.1854T>C synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7595 c.294C>G synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 7601 c.300C>G synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7784 c.483A>G synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 7799 c.498A>G synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7838 c.537C>T synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 8121 c.820T>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8156 c.855T>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8168 c.867A>G synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8324 c.1023T>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8339 c.1038A>G synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 8340 p.Ala347Ser missense_variant 0.15 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8546 c.1245T>C synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8603 c.1302A>G synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8609 c.1308G>C synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8619 c.1318T>C synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8645 c.1344C>T synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8655 p.Ile452Val missense_variant 0.2 levofloxacin
moxifloxacin
gyrA 8711 c.1410A>C synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 8729 c.1428T>C synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 8897 c.1596T>C synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8903 c.1602T>C synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8998 p.Leu566Trp missense_variant 0.15 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
fgd1 490818 c.36C>T synonymous_variant 0.16 pretomanid
delamanid
clofazimine
fgd1 490830 c.48A>C synonymous_variant 0.18 pretomanid
delamanid
clofazimine
fgd1 491742 c.960T>C synonymous_variant 0.99 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R
mshA 575746 c.399C>G synonymous_variant 0.17 isoniazid
ethionamide
mshA 575785 c.438T>C synonymous_variant 0.17 isoniazid
ethionamide
mshA 575821 c.474G>C synonymous_variant 0.17 isoniazid
ethionamide
mshA 575884 c.537G>C synonymous_variant 0.19 isoniazid
ethionamide
mshA 575893 c.546C>G synonymous_variant 0.18 isoniazid
ethionamide
mshA 575905 c.558G>C synonymous_variant 0.16 isoniazid
ethionamide
mshA 575907 p.Ala187Val missense_variant 0.81 isoniazid Not assoc w R
ethionamide Not assoc w R
mshA 575916 p.Asp190Ala missense_variant 0.16 isoniazid
ethionamide
ccsA 620625 p.Ile245Met missense_variant 1.0 kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
Rv0565c 657081 c.390G>A synonymous_variant 1.0 ethionamide Not assoc w R - Interim
Rv0565c 657142 p.Arg110His missense_variant 1.0 ethionamide Uncertain significance
hadA 731774 c.-156T>C upstream_gene_variant 0.25 isoniazid
nusG 734407 p.Val52Ile missense_variant 0.19 rifampicin
nusG 734421 c.168A>G synonymous_variant 0.21 rifampicin
nusG 734481 c.228C>T synonymous_variant 0.15 rifampicin
nusG 734532 c.279A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
nusG 734559 c.306T>C synonymous_variant 0.22 rifampicin
nusG 734580 c.327T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
nusG 734589 c.336G>C synonymous_variant 0.18 rifampicin
nusG 734596 c.343T>C synonymous_variant 0.17 rifampicin
nusG 734781 c.528A>G synonymous_variant 0.18 rifampicin
nusG 734784 c.531G>A synonymous_variant 0.17 rifampicin
nusG 734826 c.573A>C synonymous_variant 0.19 rifampicin
nusG 734847 c.594T>C synonymous_variant 0.2 rifampicin
rpoB 760121 c.315T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760184 c.378A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760196 c.390C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760235 c.429T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 760307 c.501T>C synonymous_variant 0.23 rifampicin
rpoB 760328 c.522G>C synonymous_variant 0.21 rifampicin
rpoB 760340 c.534G>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760361 c.555T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760424 c.618C>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760430 c.624T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760475 c.669A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760484 c.678A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760563 p.Arg253Met missense_variant 0.18 rifampicin Uncertain significance
rpoB 760591 p.Val262Ala missense_variant 0.21 rifampicin
rpoB 760611 c.805T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760646 c.840C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760655 c.849A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760661 c.855A>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760670 c.864G>C synonymous_variant 0.18 rifampicin
rpoB 760674 c.868T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760679 c.873A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760830 c.1024T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760841 c.1035T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760928 c.1122G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760946 c.1140A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 761015 c.1209G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 761027 c.1221A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761037 c.1231T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761097 c.1291_1292delAGinsTC synonymous_variant 0.18 rifampicin
rpoB 761102 c.1296A>G synonymous_variant 0.18 rifampicin
rpoB 761133 c.1327_1329delTTGinsCTC synonymous_variant 0.17 rifampicin
rpoB 761207 c.1401C>T synonymous_variant 0.17 rifampicin
rpoB 761249 c.1443A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761255 c.1449T>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 761327 c.1521A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 761354 c.1548C>T synonymous_variant 0.16 rifampicin
rpoB 761360 c.1554T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761408 c.1602G>C synonymous_variant 0.18 rifampicin
rpoB 761423 c.1617T>C synonymous_variant 0.19 rifampicin
rpoB 761435 c.1629T>C synonymous_variant 0.18 rifampicin
rpoB 761444 c.1638T>C synonymous_variant 0.16 rifampicin
rpoB 761483 c.1677G>C synonymous_variant 0.19 rifampicin
rpoB 761492 c.1686G>C synonymous_variant 0.21 rifampicin
rpoB 761537 c.1731C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761561 c.1755C>G synonymous_variant 0.21 rifampicin
rpoB 761564 c.1758G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761573 c.1767C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 761579 c.1773G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761606 c.1800C>G synonymous_variant 0.23 rifampicin
rpoB 761612 c.1806G>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 761615 c.1809A>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 761636 c.1830G>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 761645 c.1839C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761648 c.1842T>C synonymous_variant 0.2 rifampicin
rpoB 761657 c.1851C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 762017 c.2211A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 762053 c.2247T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 762083 c.2277T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 762086 c.2280G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 762114 p.Ile770Val missense_variant 0.21 rifampicin Uncertain significance
rpoB 762185 c.2379G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 762254 c.2448T>C synonymous_variant 0.99 rifampicin Not assoc w R - Interim
rpoB 762257 c.2451C>G synonymous_variant 0.19 rifampicin
rpoB 762284 c.2478G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 762293 c.2487T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 762395 c.-975G>C upstream_gene_variant 0.16 rifampicin
rpoC 762398 c.-972T>C upstream_gene_variant 0.16 rifampicin
rpoB 762404 c.2598T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 762410 c.-960T>C upstream_gene_variant 0.18 rifampicin
rpoB 762416 c.2610A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 762470 c.2664G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 762857 c.3051C>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 762995 c.3189G>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 763028 c.3222T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>C synonymous_variant 1.0 rifampicin Not assoc w R
rpoB 763034 c.3228C>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 763040 c.3234C>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 763070 c.3264T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 763085 c.3279C>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 763115 c.3309T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 763127 c.3321G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 763169 c.-201A>G upstream_gene_variant 0.19 rifampicin
rpoC 763202 c.-168A>G upstream_gene_variant 0.16 rifampicin
rpoC 763206 c.-164_-163delAGinsTC upstream_gene_variant 0.16 rifampicin
rpoC 763414 c.45T>C synonymous_variant 0.15 rifampicin
rpoC 763444 c.75T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 763456 c.87A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 763486 c.117T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 763636 c.267T>G synonymous_variant 0.21 rifampicin
rpoC 763660 c.291T>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 763702 c.333C>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 763714 c.345G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 763732 c.363C>G synonymous_variant 0.2 rifampicin
rpoC 763744 c.375G>C synonymous_variant 0.2 rifampicin
rpoC 763765 c.396T>C synonymous_variant 0.22 rifampicin
rpoC 763781 p.Ser138Ala missense_variant 0.23 rifampicin
rpoC 763807 c.438T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 763836 p.Ala156Val missense_variant 0.19 rifampicin
rpoC 763855 c.486C>T synonymous_variant 0.15 rifampicin
rpoC 763993 p.Ile208Met missense_variant 0.15 rifampicin
rpoC 763996 c.627T>C synonymous_variant 0.15 rifampicin
rpoC 764005 c.636G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 764024 c.655T>C synonymous_variant 0.2 rifampicin
rpoC 764083 c.714A>G synonymous_variant 0.23 rifampicin
rpoC 764098 c.729A>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 764278 c.909A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 764317 c.948C>G synonymous_variant 0.16 rifampicin
rpoC 764365 c.996C>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764387 c.1018T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 764405 c.1036A>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764431 c.1062G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764434 c.1065A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764446 c.1077T>C synonymous_variant 0.17 rifampicin
rpoC 764449 c.1080G>C synonymous_variant 0.16 rifampicin
rpoC 764458 c.1089G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764461 c.1092A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 764497 c.1128A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764500 c.1131C>G synonymous_variant 0.17 rifampicin
rpoC 764521 c.1152T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764536 c.1167G>C synonymous_variant 0.17 rifampicin
rpoC 764539 c.1170C>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 764548 c.1179G>A synonymous_variant 0.16 rifampicin
rpoC 764554 c.1185C>T synonymous_variant 0.17 rifampicin
rpoC 764575 c.1206T>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764626 c.1257C>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 764668 c.1299C>T synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 764752 c.1383G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764764 c.1395T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764809 c.1440C>T synonymous_variant 0.17 rifampicin Not assoc w R
rpoC 764815 c.1446A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 764833 c.1464A>G synonymous_variant 0.18 rifampicin
rpoC 764872 c.1503A>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 764923 c.1554A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 765478 c.2109T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 765547 c.2178C>A synonymous_variant 0.23 rifampicin
rpoC 765556 c.2187G>C synonymous_variant 0.22 rifampicin
rpoC 765562 c.2193G>C synonymous_variant 0.21 rifampicin
rpoC 765583 c.2214G>T synonymous_variant 0.19 rifampicin
rpoC 765628 c.2259G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 765700 c.2331T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 765734 c.2365T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 765784 c.2415C>G synonymous_variant 0.16 rifampicin
rpoC 765787 c.2418C>T synonymous_variant 0.16 rifampicin
rpoC 765793 c.2424C>G synonymous_variant 0.16 rifampicin
rpoC 765796 c.2427C>T synonymous_variant 0.16 rifampicin
rpoC 765811 c.2442T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 765835 c.2466C>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 765883 c.2514C>G synonymous_variant 0.2 rifampicin
rpoC 765886 c.2517C>G synonymous_variant 0.22 rifampicin
rpoC 765892 c.2523T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 765952 c.2583G>C synonymous_variant 0.2 rifampicin
rpoC 765967 c.2598C>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 765979 c.2610C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 765994 c.2625A>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 766381 c.3012C>T synonymous_variant 0.18 rifampicin
rpoC 766384 c.3015A>G synonymous_variant 0.18 rifampicin
rpoC 766408 c.3039C>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 766426 c.3057C>T synonymous_variant 0.24 rifampicin
rpoC 766486 c.3117A>G synonymous_variant 0.22 rifampicin
rpoC 766543 c.3174C>T synonymous_variant 0.2 rifampicin
rpoC 766573 c.3204T>C synonymous_variant 0.2 rifampicin
rpoC 766585 c.3216T>C synonymous_variant 0.21 rifampicin
rpoC 766594 c.3225G>C synonymous_variant 0.2 rifampicin
rpoC 766607 p.Ile1080Leu missense_variant 0.21 rifampicin
rpoC 766657 c.3288A>G synonymous_variant 0.17 rifampicin
rpoC 766672 c.3303T>C synonymous_variant 0.18 rifampicin
rpoC 766726 c.3357T>C synonymous_variant 0.21 rifampicin
rpoC 766765 c.3396A>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 766774 c.3405T>C synonymous_variant 0.25 rifampicin
rpoC 766801 c.3432C>T synonymous_variant 0.15 rifampicin
rpoC 766804 c.3435A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 766864 c.3495G>C synonymous_variant 0.17 rifampicin
rpoC 766963 c.3594T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 766972 c.3603G>C synonymous_variant 0.18 rifampicin
rpoC 766996 c.3627C>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 767002 c.3633G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 767033 c.3664_3666delTCGinsAGT synonymous_variant 0.23 rifampicin
rpoC 767059 c.3690T>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 767062 c.3693C>A synonymous_variant 0.28 rifampicin
rpoC 767098 c.3729T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 767119 c.3750A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 767200 c.3831G>A synonymous_variant 0.17 rifampicin
rpoC 767221 c.3852C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 767233 c.3864T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
mmpL5 775639 p.Ile948Val missense_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
mmpL5 776100 p.Thr794Ile missense_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
mmpL5 776182 p.Asp767Asn missense_variant 1.0 bedaquiline Not assoc w R
clofazimine Not assoc w R
mmpS5 779615 c.-710C>G upstream_gene_variant 0.99 bedaquiline
clofazimine
rpsL 781395 c.-165T>C upstream_gene_variant 0.98 streptomycin Not assoc w R
rpsL 781609 p.Ser17Thr missense_variant 0.15 streptomycin
rpsL 781628 c.69T>C synonymous_variant 0.17 streptomycin Not assoc w R - Interim
rpsL 781649 c.90T>C synonymous_variant 0.2 streptomycin
rpsL 781655 c.96T>C synonymous_variant 0.19 streptomycin
rpsL 781715 c.156T>C synonymous_variant 0.18 streptomycin
rpsL 781718 c.159C>G synonymous_variant 0.18 streptomycin
rpsL 781728 c.169T>C synonymous_variant 0.21 streptomycin
rpsL 781760 c.201T>C synonymous_variant 0.24 streptomycin
rpsL 781808 c.249C>T synonymous_variant 0.21 streptomycin
rpsL 781832 c.273T>C synonymous_variant 0.21 streptomycin
rpsL 781868 c.309T>C synonymous_variant 0.17 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.17 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.17 streptomycin
rpsL 781898 c.339A>T synonymous_variant 0.17 streptomycin
rpsL 781916 c.357T>C synonymous_variant 0.17 streptomycin
rpsL 781929 p.Gly124Ser missense_variant 0.17 streptomycin Uncertain significance
rplC 800567 c.-242A>G upstream_gene_variant 0.2 linezolid
rplC 800579 c.-230C>T upstream_gene_variant 0.2 linezolid
rplC 800582 c.-227C>G upstream_gene_variant 0.2 linezolid
rplC 800612 c.-197A>G upstream_gene_variant 0.18 linezolid
rplC 800618 c.-191T>C upstream_gene_variant 0.18 linezolid
rplC 800648 c.-161A>C upstream_gene_variant 0.19 linezolid
rplC 800693 c.-116A>C upstream_gene_variant 0.21 linezolid
rplC 800714 c.-95C>T upstream_gene_variant 0.18 linezolid
rplC 800715 c.-94A>C upstream_gene_variant 0.18 linezolid
rplC 800723 c.-86C>G upstream_gene_variant 0.18 linezolid
rplC 800844 c.36T>C synonymous_variant 0.15 linezolid
rplC 801210 c.402T>C synonymous_variant 0.15 linezolid
rplC 801312 c.504G>C synonymous_variant 0.18 linezolid
rplC 801339 c.531T>G synonymous_variant 0.15 linezolid
rplC 801348 c.540T>G synonymous_variant 0.15 linezolid
rplC 801357 c.549T>C synonymous_variant 0.15 linezolid
Rv1129c 1254562 c.-28T>C upstream_gene_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
isoniazid Not assoc w R
rifampicin Not assoc w R
fbiC 1303545 c.615A>G synonymous_variant 0.18 pretomanid
delamanid
clofazimine
fbiC 1304625 c.1695C>T synonymous_variant 0.16 pretomanid
delamanid
clofazimine
fbiC 1304784 c.1854T>G synonymous_variant 0.18 pretomanid
delamanid
clofazimine
fbiC 1304787 c.1857T>C synonymous_variant 0.18 pretomanid
delamanid
clofazimine
fbiC 1304799 c.1869G>C synonymous_variant 0.19 pretomanid
delamanid
clofazimine
fbiC 1304832 c.1902C>T synonymous_variant 0.22 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R - Interim
fbiC 1304856 c.1926C>G synonymous_variant 0.2 pretomanid
delamanid
clofazimine
fbiC 1304893 p.Gly655Ser missense_variant 0.19 pretomanid
delamanid
clofazimine
fbiC 1304915 p.Asp662Gly missense_variant 0.16 pretomanid
delamanid
clofazimine
sigE 1364889 c.477A>G synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
Rv1258c 1406760 c.580_581insC frameshift_variant 0.99 streptomycin Uncertain significance
pyrazinamide Uncertain significance
isoniazid Uncertain significance
atpE 1461219 c.175T>C synonymous_variant 0.16 bedaquiline
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 kanamycin
capreomycin
streptomycin
amikacin
rrs 1471970 n.125G>A non_coding_transcript_exon_variant 0.18 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472040 n.195T>C non_coding_transcript_exon_variant 0.21 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472053 n.211_212delGC non_coding_transcript_exon_variant 0.23 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472061 n.216A>T non_coding_transcript_exon_variant 0.25 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472075 n.230A>G non_coding_transcript_exon_variant 0.27 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472969 n.1124A>G non_coding_transcript_exon_variant 0.22 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472977 n.1132G>C non_coding_transcript_exon_variant 0.14 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472978 n.1133T>C non_coding_transcript_exon_variant 0.21 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473123 n.1278delAinsTT non_coding_transcript_exon_variant 0.24 kanamycin
capreomycin
streptomycin
amikacin
rrl 1473758 n.101G>T non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid
rrl 1473806 n.149C>T non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473877 n.220G>A non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1473887 n.230T>A non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1473888 n.231T>A non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473995 n.338G>T non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1474009 n.352A>G non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
rrl 1474083 n.426C>T non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid
rrl 1474103 n.446A>T non_coding_transcript_exon_variant 0.29 capreomycin
linezolid
rrl 1474140 n.483C>T non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474632 n.975G>T non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474639 n.982G>A non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474673 n.1016T>C non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474717 n.1060A>T non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>A non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474831 n.1174A>G non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid
rrl 1475061 n.1404C>T non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid
rrl 1475266 n.1609T>C non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475273 n.1616T>G non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1475289 n.1632G>A non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1475290 n.1633A>G non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1475291 n.1634A>C non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475315 n.1658A>T non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475333 n.1676T>C non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1475355 n.1698C>T non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475369 n.1712G>A non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1475402 n.1746T>A non_coding_transcript_exon_variant 0.15 capreomycin
linezolid
rrl 1475429 n.1772G>A non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475608 n.1951T>C non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid
rrl 1475638 n.1981C>T non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1475659 n.2002G>A non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475881 n.2224T>C non_coding_transcript_exon_variant 0.15 capreomycin
linezolid
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.28 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476035 n.2378G>A non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1476049 n.2392C>T non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476086 n.2429G>A non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476089 n.2432T>C non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1476095 n.2438C>G non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1476115 n.2458T>C non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476251 n.2594T>C non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476297 n.2640C>T non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476299 n.2642C>T non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476580 n.2923G>A non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1476597 n.2940G>A non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid
rrl 1476619 n.2962C>T non_coding_transcript_exon_variant 0.24 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476726 n.3069A>G non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
rrl 1476732 n.3075T>C non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
inhA 1674870 c.669T>C synonymous_variant 0.2 isoniazid
ethionamide
inhA 1674903 c.702T>C synonymous_variant 0.15 isoniazid
ethionamide
inhA 1674904 p.Ala235Pro missense_variant 0.15 isoniazid
ethionamide
rpsA 1833589 c.48A>T synonymous_variant 0.19 pyrazinamide
rpsA 1833724 c.183C>G synonymous_variant 0.21 pyrazinamide
rpsA 1833727 c.186G>C synonymous_variant 0.2 pyrazinamide
rpsA 1833745 c.204G>C synonymous_variant 0.22 pyrazinamide
rpsA 1833802 c.261A>G synonymous_variant 0.21 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.19 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.2 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.21 pyrazinamide
rpsA 1833874 c.333T>C synonymous_variant 0.22 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.25 pyrazinamide
rpsA 1833949 c.408T>C synonymous_variant 0.24 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.21 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.22 pyrazinamide
rpsA 1834030 c.489C>G synonymous_variant 0.2 pyrazinamide
rpsA 1834051 c.510G>A synonymous_variant 0.2 pyrazinamide
rpsA 1834177 c.636A>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
rpsA 1834249 c.708T>C synonymous_variant 0.2 pyrazinamide
rpsA 1834261 c.720A>G synonymous_variant 0.21 pyrazinamide Not assoc w R - Interim
rpsA 1834306 c.765T>C synonymous_variant 0.17 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
rpsA 1834366 c.825A>G synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
rpsA 1834396 c.855G>C synonymous_variant 0.22 pyrazinamide
rpsA 1834411 c.870T>C synonymous_variant 0.21 pyrazinamide
rpsA 1834417 c.876G>C synonymous_variant 0.2 pyrazinamide
rpsA 1834451 c.910T>C synonymous_variant 0.2 pyrazinamide
rpsA 1834456 c.915T>G synonymous_variant 0.19 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.2 pyrazinamide
rpsA 1834489 c.948T>C synonymous_variant 0.21 pyrazinamide
rpsA 1834495 c.954G>A synonymous_variant 0.2 pyrazinamide
rpsA 1834528 c.987T>C synonymous_variant 0.24 pyrazinamide
rpsA 1834546 c.1005T>C synonymous_variant 0.23 pyrazinamide
rpsA 1834609 c.1068T>C synonymous_variant 0.22 pyrazinamide
rpsA 1834615 c.1074C>T synonymous_variant 0.21 pyrazinamide
rpsA 1834633 c.1092A>G synonymous_variant 0.22 pyrazinamide
rpsA 1834639 c.1098T>C synonymous_variant 0.22 pyrazinamide
rpsA 1834690 c.1149T>C synonymous_variant 0.17 pyrazinamide
tsnR 1853574 c.-32T>C upstream_gene_variant 1.0 linezolid
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
katG 2154724 p.Arg463Leu missense_variant 1.0 isoniazid Not assoc w R
PPE35 2167926 p.Leu896Ser missense_variant 1.0 pyrazinamide Not assoc w R
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
kasA 2517941 c.-174C>G upstream_gene_variant 0.17 isoniazid
kasA 2518561 c.447T>C synonymous_variant 0.15 isoniazid
kasA 2518567 c.453G>T synonymous_variant 0.15 isoniazid
kasA 2518672 c.558G>C synonymous_variant 0.2 isoniazid
kasA 2518711 c.597A>G synonymous_variant 0.23 isoniazid
kasA 2518747 c.633C>G synonymous_variant 0.22 isoniazid
kasA 2518783 c.669T>C synonymous_variant 0.2 isoniazid
kasA 2518795 c.681C>G synonymous_variant 0.16 isoniazid
kasA 2518825 c.711T>C synonymous_variant 0.18 isoniazid
kasA 2518864 c.750G>C synonymous_variant 0.17 isoniazid
kasA 2518885 c.771T>C synonymous_variant 0.19 isoniazid
kasA 2518906 c.792A>G synonymous_variant 0.17 isoniazid
kasA 2518939 c.825T>C synonymous_variant 0.16 isoniazid
kasA 2518942 c.828T>C synonymous_variant 0.16 isoniazid
ahpC 2726348 c.156T>C synonymous_variant 0.15 isoniazid
Rv2477c 2783194 c.849A>G synonymous_variant 0.18 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783329 c.714G>A synonymous_variant 0.18 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783332 c.711T>C synonymous_variant 0.18 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783359 c.684G>A synonymous_variant 0.19 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783374 c.669G>C synonymous_variant 0.18 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783395 c.648T>C synonymous_variant 0.22 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783410 c.633G>C synonymous_variant 0.2 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783422 c.621T>C synonymous_variant 0.17 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783428 c.615C>T synonymous_variant 0.18 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
rifampicin Not assoc w R - Interim
ethambutol
amikacin Not assoc w R - Interim
Rv2477c 2783461 c.582T>C synonymous_variant 0.15 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783674 c.369T>C synonymous_variant 0.18 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783683 c.360A>G synonymous_variant 0.19 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783700 p.Thr115Ser missense_variant 0.2 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783751 p.Ile98Val missense_variant 0.17 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783857 c.186C>G synonymous_variant 0.15 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783860 c.183T>C synonymous_variant 0.2 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783883 c.160T>C synonymous_variant 0.26 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783884 c.159T>A synonymous_variant 0.16 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783920 c.123G>C synonymous_variant 0.18 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783926 c.117C>G synonymous_variant 0.15 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783956 c.87T>C synonymous_variant 0.27 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783971 c.72G>C synonymous_variant 0.26 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783992 c.51T>C synonymous_variant 0.22 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin
Rv2477c 2784477 c.-435T>C upstream_gene_variant 0.16 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
thyX 3067316 c.630A>G synonymous_variant 0.17 para-aminosalicylic_acid
thyX 3067325 c.621A>G synonymous_variant 0.18 para-aminosalicylic_acid
thyX 3067373 c.573C>G synonymous_variant 0.19 para-aminosalicylic_acid
thyX 3067874 c.72C>G synonymous_variant 0.17 para-aminosalicylic_acid
thyA 3073932 c.540C>T synonymous_variant 0.19 para-aminosalicylic_acid
thyA 3073977 c.495A>G synonymous_variant 0.2 para-aminosalicylic_acid
thyA 3073989 c.483T>C synonymous_variant 0.22 para-aminosalicylic_acid
thyA 3074031 c.441T>C synonymous_variant 0.19 para-aminosalicylic_acid
thyA 3074037 c.435C>G synonymous_variant 0.18 para-aminosalicylic_acid
thyA 3074053 p.Arg140Gln missense_variant 0.17 para-aminosalicylic_acid
thyA 3074056 p.Glu139Pro missense_variant 0.16 para-aminosalicylic_acid
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
Rv3236c 3612813 p.Thr102Ala missense_variant 0.97 pyrazinamide Not assoc w R - Interim
mtrB 3625065 p.Met517Leu missense_variant 1.0 rifampicin Not assoc w R
bedaquiline Uncertain significance
mtrB 3625729 c.885A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625755 p.Ala287Thr missense_variant 0.17 rifampicin Uncertain significance
bedaquiline
mtrB 3626562 p.Pro18Ser missense_variant 0.99 rifampicin Not assoc w R
bedaquiline Uncertain significance
mtrA 3626804 c.546A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
bedaquiline
mtrA 3626846 c.504G>A synonymous_variant 0.19 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626852 c.-239G>A upstream_gene_variant 0.19 rifampicin
bedaquiline
mtrB 3626857 c.-244T>C upstream_gene_variant 0.18 rifampicin
bedaquiline
mtrB 3626866 c.-253T>C upstream_gene_variant 0.2 rifampicin
bedaquiline
mtrB 3626890 c.-277T>C upstream_gene_variant 0.2 rifampicin
bedaquiline
mtrA 3626912 c.438T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626972 c.-359A>G upstream_gene_variant 0.16 rifampicin
bedaquiline
mtrB 3627071 c.-458G>C upstream_gene_variant 0.21 rifampicin
bedaquiline
mtrA 3627098 c.252A>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627104 c.-491C>G upstream_gene_variant 0.2 rifampicin
bedaquiline
mtrB 3627182 c.-569T>C upstream_gene_variant 0.16 rifampicin
bedaquiline
mtrA 3627190 c.160T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627203 c.-590C>G upstream_gene_variant 0.18 rifampicin
bedaquiline
mtrA 3627242 c.108C>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627266 c.-653A>G upstream_gene_variant 0.16 rifampicin
bedaquiline
mtrB 3627272 c.-659G>T upstream_gene_variant 0.16 rifampicin
bedaquiline
mtrB 3627287 c.-674C>G upstream_gene_variant 0.15 rifampicin
bedaquiline
fbiA 3640298 c.-245A>G upstream_gene_variant 0.14 pretomanid
delamanid
clofazimine
rpoA 3877587 c.921A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3877613 p.Ile299Val missense_variant 0.18 rifampicin
rpoA 3877668 c.840A>G synonymous_variant 0.15 rifampicin
rpoA 3877764 c.744C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3877770 c.738A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3877776 c.732T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoA 3877782 c.726T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3877839 c.669G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3877875 c.633T>G synonymous_variant 0.16 rifampicin
rpoA 3877909 p.Asn200Ser missense_variant 0.16 rifampicin
rpoA 3877986 c.522G>C synonymous_variant 0.22 rifampicin
rpoA 3877989 c.519A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoA 3878001 c.507A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoA 3878022 c.486T>C synonymous_variant 0.18 rifampicin
rpoA 3878025 c.483C>T synonymous_variant 0.17 rifampicin
rpoA 3878028 c.480G>C synonymous_variant 0.17 rifampicin
rpoA 3878031 c.477T>C synonymous_variant 0.17 rifampicin
rpoA 3878106 c.402G>C synonymous_variant 0.18 rifampicin
rpoA 3878118 c.390T>C synonymous_variant 0.18 rifampicin
rpoA 3878157 c.351C>G synonymous_variant 0.23 rifampicin
rpoA 3878163 c.345C>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoA 3878172 c.336G>C synonymous_variant 0.15 rifampicin
rpoA 3878193 c.315T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoA 3878202 c.306G>C synonymous_variant 0.16 rifampicin
rpoA 3878217 c.291A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoA 3878247 c.261G>C synonymous_variant 0.23 rifampicin
rpoA 3878256 c.252G>C synonymous_variant 0.28 rifampicin
rpoA 3878262 c.246C>T synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoA 3878271 c.237T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoA 3878283 p.Glu75Asp missense_variant 0.25 rifampicin Uncertain significance
rpoA 3878295 c.213A>G synonymous_variant 0.23 rifampicin
rpoA 3878298 c.210A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoA 3878331 c.177A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoA 3878334 c.174T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoA 3878337 c.171T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoA 3878406 c.102G>T synonymous_variant 0.19 rifampicin
rpoA 3878442 c.66G>C synonymous_variant 0.16 rifampicin
rpoA 3878454 c.54A>G synonymous_variant 0.15 rifampicin
rpoA 3878809 c.-302T>C upstream_gene_variant 0.17 rifampicin
rpoA 3878853 c.-346G>A upstream_gene_variant 0.22 rifampicin
rpoA 3878878 c.-371T>C upstream_gene_variant 0.23 rifampicin Uncertain significance
rpoA 3878909 c.-402A>G upstream_gene_variant 0.22 rifampicin
rpoA 3878914 c.-407T>C upstream_gene_variant 0.2 rifampicin Uncertain significance
rpoA 3878938 c.-431T>C upstream_gene_variant 0.17 rifampicin
rpoA 3879088 c.-581A>C upstream_gene_variant 0.22 rifampicin
rpoA 3879094 c.-587T>C upstream_gene_variant 0.23 rifampicin
rpoA 3879121 c.-614T>G upstream_gene_variant 0.25 rifampicin
rpoA 3879148 c.-641G>C upstream_gene_variant 0.15 rifampicin
rpoA 3879154 c.-647T>C upstream_gene_variant 0.26 rifampicin
rpoA 3879160 c.-653A>G upstream_gene_variant 0.26 rifampicin
rpoA 3879172 c.-665C>T upstream_gene_variant 0.16 rifampicin
rpoA 3879184 c.-677G>A upstream_gene_variant 0.16 rifampicin
rpoA 3879222 c.-715T>C upstream_gene_variant 0.16 rifampicin
clpC1 4038278 c.2427T>C synonymous_variant 0.21 pyrazinamide
clpC1 4038314 c.2391T>G synonymous_variant 0.15 pyrazinamide
clpC1 4038350 c.2355C>G synonymous_variant 0.21 pyrazinamide
clpC1 4038356 c.2349T>C synonymous_variant 0.2 pyrazinamide
clpC1 4038359 c.2346A>G synonymous_variant 0.2 pyrazinamide
clpC1 4038368 c.2337T>C synonymous_variant 0.18 pyrazinamide
clpC1 4038403 c.2302T>C synonymous_variant 0.16 pyrazinamide Not assoc w R - Interim
clpC1 4038456 p.Val750Glu missense_variant 0.14 pyrazinamide
clpC1 4038519 p.Arg729Gln missense_variant 0.2 pyrazinamide
clpC1 4038530 p.Glu725Asp missense_variant 0.2 pyrazinamide
clpC1 4038536 c.2169C>T synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
clpC1 4038596 c.2109A>G synonymous_variant 0.2 pyrazinamide
clpC1 4038790 c.1915C>T synonymous_variant 0.21 pyrazinamide Not assoc w R - Interim
clpC1 4038812 c.1893T>C synonymous_variant 0.22 pyrazinamide
clpC1 4038878 c.1827A>G synonymous_variant 0.22 pyrazinamide Not assoc w R - Interim
clpC1 4038908 c.1797C>G synonymous_variant 0.19 pyrazinamide
clpC1 4038914 c.1791G>C synonymous_variant 0.19 pyrazinamide
clpC1 4038923 c.1782A>G synonymous_variant 0.18 pyrazinamide
clpC1 4038953 c.1752A>G synonymous_variant 0.2 pyrazinamide
clpC1 4038956 c.1749T>C synonymous_variant 0.2 pyrazinamide
clpC1 4038965 c.1740T>C synonymous_variant 0.18 pyrazinamide
clpC1 4038971 c.1734T>C synonymous_variant 0.17 pyrazinamide
clpC1 4038974 c.1731T>C synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
clpC1 4038980 c.1725C>T synonymous_variant 0.18 pyrazinamide
clpC1 4038989 c.1716T>C synonymous_variant 0.17 pyrazinamide
clpC1 4039022 c.1683A>G synonymous_variant 0.18 pyrazinamide
clpC1 4039085 c.1620A>G synonymous_variant 0.17 pyrazinamide
clpC1 4039097 c.1608G>C synonymous_variant 0.16 pyrazinamide
clpC1 4039103 c.1602T>C synonymous_variant 0.16 pyrazinamide
clpC1 4039106 c.1599G>C synonymous_variant 0.16 pyrazinamide
clpC1 4039112 c.1593C>G synonymous_variant 0.17 pyrazinamide
clpC1 4039121 c.1584T>C synonymous_variant 0.17 pyrazinamide
clpC1 4039133 c.1572C>G synonymous_variant 0.17 pyrazinamide
clpC1 4039142 c.1563A>G synonymous_variant 0.17 pyrazinamide
clpC1 4039145 c.1560G>C synonymous_variant 0.17 pyrazinamide
clpC1 4039172 c.1533A>G synonymous_variant 0.17 pyrazinamide
clpC1 4039183 c.1522T>C synonymous_variant 0.17 pyrazinamide
clpC1 4039226 c.1479T>C synonymous_variant 0.18 pyrazinamide Not assoc w R - Interim
clpC1 4039286 c.1419T>C synonymous_variant 0.19 pyrazinamide
clpC1 4039292 c.1413C>T synonymous_variant 0.19 pyrazinamide
clpC1 4039319 c.1386T>C synonymous_variant 0.18 pyrazinamide Not assoc w R - Interim
clpC1 4039391 c.1314T>G synonymous_variant 0.18 pyrazinamide
clpC1 4039409 c.1296T>C synonymous_variant 0.17 pyrazinamide
clpC1 4039412 c.1293T>G synonymous_variant 0.16 pyrazinamide
clpC1 4039463 c.1242C>G synonymous_variant 0.16 pyrazinamide
clpC1 4039466 c.1239T>C synonymous_variant 0.15 pyrazinamide
clpC1 4039469 c.1236T>C synonymous_variant 0.16 pyrazinamide
clpC1 4039481 c.1224T>C synonymous_variant 0.2 pyrazinamide
clpC1 4039517 c.1188C>G synonymous_variant 0.19 pyrazinamide
clpC1 4039610 c.1095G>C synonymous_variant 0.17 pyrazinamide
clpC1 4039616 c.1089G>C synonymous_variant 0.17 pyrazinamide
clpC1 4039661 c.1044T>C synonymous_variant 0.23 pyrazinamide
clpC1 4039694 c.1011G>C synonymous_variant 0.2 pyrazinamide
clpC1 4039724 c.981A>G synonymous_variant 0.2 pyrazinamide
clpC1 4039751 c.954A>G synonymous_variant 0.18 pyrazinamide
clpC1 4039820 c.885T>C synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
clpC1 4039826 c.879C>G synonymous_variant 0.17 pyrazinamide
clpC1 4039831 c.874T>C synonymous_variant 0.17 pyrazinamide
clpC1 4039850 c.855T>C synonymous_variant 0.2 pyrazinamide
clpC1 4039865 c.840T>C synonymous_variant 0.2 pyrazinamide
clpC1 4039898 c.807C>G synonymous_variant 0.17 pyrazinamide
clpC1 4039931 c.774T>C synonymous_variant 0.19 pyrazinamide
clpC1 4039952 c.753T>C synonymous_variant 0.18 pyrazinamide
clpC1 4039958 c.747G>C synonymous_variant 0.17 pyrazinamide
clpC1 4040021 c.684A>C synonymous_variant 0.16 pyrazinamide Not assoc w R - Interim
clpC1 4040033 c.672G>C synonymous_variant 0.17 pyrazinamide
clpC1 4040105 c.600C>G synonymous_variant 0.17 pyrazinamide
clpC1 4040480 c.225T>C synonymous_variant 0.15 pyrazinamide Not assoc w R - Interim
clpC1 4040522 c.183T>C synonymous_variant 0.15 pyrazinamide Not assoc w R - Interim
clpC1 4040551 c.154T>C synonymous_variant 0.15 pyrazinamide Not assoc w R - Interim
embC 4240486 c.624G>A synonymous_variant 0.16 ethambutol
embC 4240489 c.627A>G synonymous_variant 0.16 ethambutol
embC 4240495 c.633T>C synonymous_variant 0.16 ethambutol
embC 4240783 c.921G>C synonymous_variant 0.17 ethambutol
embC 4241140 c.1278A>G synonymous_variant 0.18 ethambutol Not assoc w R - Interim
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
embA 4243460 c.228C>T synonymous_variant 0.99 ethambutol Not assoc w R
embA 4244885 c.1653A>G synonymous_variant 0.16 ethambutol
embB 4246567 c.54G>T synonymous_variant 1.0 ethambutol Not assoc w R - Interim
embB 4247470 c.957T>C synonymous_variant 0.27 ethambutol
embB 4247497 c.984T>C synonymous_variant 0.24 ethambutol
embB 4247500 c.987C>G synonymous_variant 0.24 ethambutol
embB 4247512 c.999T>C synonymous_variant 0.23 ethambutol
embB 4247554 c.1041T>C synonymous_variant 0.19 ethambutol
embB 4247590 c.1077A>G synonymous_variant 0.15 ethambutol Not assoc w R - Interim
embB 4248055 c.1542G>C synonymous_variant 0.18 ethambutol
embB 4248064 c.1551G>C synonymous_variant 0.18 ethambutol Not assoc w R - Interim
embB 4248070 c.1557T>C synonymous_variant 0.19 ethambutol
embB 4248130 c.1617G>C synonymous_variant 0.2 ethambutol
embB 4248142 c.1629T>C synonymous_variant 0.19 ethambutol
embB 4248206 p.Ser565Gly missense_variant 0.19 ethambutol Uncertain significance
embB 4248217 c.1704C>G synonymous_variant 0.17 ethambutol
embB 4248220 c.1707A>G synonymous_variant 0.18 ethambutol Not assoc w R - Interim
embB 4248233 c.1720C>T synonymous_variant 0.17 ethambutol
embB 4248277 c.1764G>C synonymous_variant 0.18 ethambutol
embB 4248280 c.1767C>G synonymous_variant 0.18 ethambutol
embB 4248316 c.1803C>G synonymous_variant 0.18 ethambutol
embB 4248319 c.1806A>G synonymous_variant 0.18 ethambutol
aftB 4267647 p.Asp397Gly missense_variant 0.86 ethambutol Not assoc w R
ubiA 4269222 c.612T>G synonymous_variant 0.16 ethambutol Not assoc w R - Interim
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 kanamycin
capreomycin
amikacin
gid 4407588 c.615A>G synonymous_variant 0.99 streptomycin Not assoc w R
gid 4407927 p.Glu92Asp missense_variant 1.0 streptomycin Not assoc w R