TB-Profiler result

Run: SAMN02585910
Summary

Run ID: SAMN02585910

Sample name:

Date: 2024-04-14T03:02:29.722035

Number of reads: 13051523

Percentage reads mapped: 73.41

Median coverage: 289.0

Strain: lineage2.2.1

Spoligotype:

Drug-resistance: RR-TB

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage2 East-Asian RD105 0.98
lineage2.2.1 East-Asian (Beijing) RD105;RD207;RD181 0.98
lineage2.2 East-Asian (Beijing) RD105;RD207 0.99
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin rpoB c.1327_1329delTTGinsCC Assoc w R - Interim Expert rule: Non-silent variants in RRDR of rpoB
isoniazid
ethambutol embB p.His312Arg Mutation from literature
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
rpoB 761133 c.1327_1329delTTGinsCC frameshift_variant&missense_variant 0.17 rifampicin Assoc w R - Interim Expert rule: Non-silent variants in RRDR of rpoB
embB 4247448 p.His312Arg missense_variant 0.24 ethambutol Mutation from literature
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
dnaA 1092 c.1092T>C synonymous_variant 0.17 isoniazid Not assoc w R - Interim
dnaA 1245 c.1245G>C synonymous_variant 0.19 isoniazid Not assoc w R - Interim
dnaA 1254 c.1254T>C synonymous_variant 0.2 isoniazid
dnaA 1278 c.1278T>C synonymous_variant 0.18 isoniazid
gyrB 6145 c.906C>T synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrB 6250 c.1011A>G synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6259 p.Asp340Glu missense_variant 0.19 levofloxacin
moxifloxacin
gyrB 6286 c.1047T>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrB 6307 c.1068T>G synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6331 c.-971A>G upstream_gene_variant 0.17 levofloxacin
moxifloxacin
gyrB 7060 c.1821T>C synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 7093 c.1854T>C synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7595 c.294C>G synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 7601 c.300C>G synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7784 c.483A>G synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 7799 c.498A>G synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7838 c.537C>T synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 8121 c.820T>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8156 c.855T>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8168 c.867A>G synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8324 c.1023T>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8339 c.1038A>G synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 8340 p.Ala347Ser missense_variant 0.15 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8546 c.1245T>C synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8603 c.1302A>G synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8609 c.1308G>C synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8619 c.1318T>C synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8645 c.1344C>T synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8655 p.Ile452Val missense_variant 0.2 levofloxacin
moxifloxacin
gyrA 8711 c.1410A>C synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 8729 c.1428T>C synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 8897 c.1596T>C synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8903 c.1602T>C synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8998 p.Leu566Trp missense_variant 0.15 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
fgd1 490818 c.36C>T synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fgd1 490830 c.48A>C synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fgd1 491742 c.960T>C synonymous_variant 0.99 clofazimine Not assoc w R
pretomanid
delamanid Not assoc w R - Interim
mshA 575746 c.399C>G synonymous_variant 0.17 ethionamide
isoniazid
mshA 575785 c.438T>C synonymous_variant 0.17 ethionamide
isoniazid
mshA 575821 c.474G>C synonymous_variant 0.17 ethionamide
isoniazid
mshA 575884 c.537G>C synonymous_variant 0.19 ethionamide
isoniazid
mshA 575893 c.546C>G synonymous_variant 0.18 ethionamide
isoniazid
mshA 575905 c.558G>C synonymous_variant 0.16 ethionamide
isoniazid
mshA 575907 p.Ala187Val missense_variant 0.81 ethionamide Not assoc w R
isoniazid Not assoc w R
mshA 575916 p.Asp190Ala missense_variant 0.16 ethionamide
isoniazid
ccsA 620625 p.Ile245Met missense_variant 1.0 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Uncertain significance
Rv0565c 657081 c.390G>A synonymous_variant 1.0 ethionamide Not assoc w R - Interim
Rv0565c 657142 p.Arg110His missense_variant 1.0 ethionamide Uncertain significance
hadA 731774 c.-156T>C upstream_gene_variant 0.25 isoniazid
nusG 734407 c.154_156delGTTinsAC frameshift_variant&missense_variant 0.19 rifampicin
nusG 734421 c.168A>G synonymous_variant 0.21 rifampicin
nusG 734481 c.228C>T synonymous_variant 0.15 rifampicin
nusG 734532 c.279A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
nusG 734559 c.306T>C synonymous_variant 0.22 rifampicin
nusG 734580 c.327T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
nusG 734589 c.336G>C synonymous_variant 0.18 rifampicin
nusG 734596 c.343T>C synonymous_variant 0.17 rifampicin
nusG 734781 c.528A>G synonymous_variant 0.18 rifampicin
nusG 734784 c.531G>A synonymous_variant 0.17 rifampicin
nusG 734826 c.573A>C synonymous_variant 0.19 rifampicin
nusG 734847 c.594T>C synonymous_variant 0.2 rifampicin
rpoB 760121 c.315T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760184 c.378A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760196 c.390C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760235 c.429T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 760307 c.501T>C synonymous_variant 0.23 rifampicin
rpoB 760328 c.522G>C synonymous_variant 0.21 rifampicin
rpoB 760340 c.534G>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760361 c.555T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760424 c.618C>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760430 c.624T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760475 c.669A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760484 c.678A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760563 p.Arg253Met missense_variant 0.18 rifampicin Uncertain significance
rpoB 760591 p.Val262Ala missense_variant 0.21 rifampicin
rpoB 760611 c.805T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760646 c.840C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760655 c.849A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760661 c.855A>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760670 c.864G>C synonymous_variant 0.18 rifampicin
rpoB 760674 c.868T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760679 c.873A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760830 c.1024T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760841 c.1035T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760928 c.1122G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760946 c.1140A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 761015 c.1209G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 761027 c.1221A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761037 c.1231T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761097 c.1291_1292delAGinsTC synonymous_variant 0.18 rifampicin
rpoB 761102 c.1296A>G synonymous_variant 0.18 rifampicin
rpoB 761207 c.1401C>T synonymous_variant 0.17 rifampicin
rpoB 761249 c.1443A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761255 c.1449T>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 761327 c.1521A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 761354 c.1548C>T synonymous_variant 0.16 rifampicin
rpoB 761360 c.1554T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761408 c.1602G>C synonymous_variant 0.18 rifampicin
rpoB 761423 c.1617T>C synonymous_variant 0.19 rifampicin
rpoB 761435 c.1629T>C synonymous_variant 0.18 rifampicin
rpoB 761444 c.1638T>C synonymous_variant 0.16 rifampicin
rpoB 761483 c.1677G>C synonymous_variant 0.19 rifampicin
rpoB 761492 c.1686G>C synonymous_variant 0.21 rifampicin
rpoB 761537 c.1731C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761561 c.1755C>G synonymous_variant 0.21 rifampicin
rpoB 761564 c.1758G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761573 c.1767C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 761579 c.1773G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761606 c.1800C>G synonymous_variant 0.23 rifampicin
rpoB 761612 c.1806G>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 761615 c.1809A>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 761636 c.1830G>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 761645 c.1839C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761648 c.1842T>C synonymous_variant 0.2 rifampicin
rpoB 761657 c.1851C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 762017 c.2211A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 762053 c.2247T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 762083 c.2277T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 762086 c.2280G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 762114 p.Ile770Val missense_variant 0.21 rifampicin Uncertain significance
rpoB 762185 c.2379G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 762254 c.2448T>C synonymous_variant 0.99 rifampicin Not assoc w R - Interim
rpoB 762257 c.2451C>G synonymous_variant 0.19 rifampicin
rpoB 762284 c.2478G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 762293 c.2487T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 762395 c.-975G>C upstream_gene_variant 0.16 rifampicin
rpoC 762398 c.-972T>C upstream_gene_variant 0.16 rifampicin
rpoB 762404 c.2598T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 762410 c.-960T>C upstream_gene_variant 0.18 rifampicin
rpoB 762416 c.2610A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 762470 c.2664G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 762857 c.3051C>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 762995 c.3189G>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 763028 c.3222T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>C synonymous_variant 1.0 rifampicin Not assoc w R
rpoB 763034 c.3228C>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 763040 c.3234C>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 763070 c.3264T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 763085 c.3279C>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 763115 c.3309T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 763127 c.3321G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 763169 c.-201A>G upstream_gene_variant 0.19 rifampicin
rpoC 763202 c.-168A>G upstream_gene_variant 0.16 rifampicin
rpoC 763206 c.-164_-163delAGinsTC upstream_gene_variant 0.16 rifampicin
rpoC 763414 c.45T>C synonymous_variant 0.15 rifampicin
rpoC 763444 c.75T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 763456 c.87A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 763486 c.117T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 763636 c.267T>G synonymous_variant 0.21 rifampicin
rpoC 763660 c.291T>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 763702 c.333C>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 763714 c.345G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 763732 c.363C>G synonymous_variant 0.2 rifampicin
rpoC 763744 c.375G>C synonymous_variant 0.2 rifampicin
rpoC 763765 c.396T>C synonymous_variant 0.22 rifampicin
rpoC 763781 p.Ser138Ala missense_variant 0.23 rifampicin
rpoC 763807 c.438T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 763836 p.Ala156Val missense_variant 0.19 rifampicin
rpoC 763855 c.486C>T synonymous_variant 0.15 rifampicin
rpoC 763993 p.Ile208Met missense_variant 0.15 rifampicin
rpoC 763996 c.627T>C synonymous_variant 0.15 rifampicin
rpoC 764005 c.636G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 764024 c.655T>C synonymous_variant 0.2 rifampicin
rpoC 764083 c.714A>G synonymous_variant 0.23 rifampicin
rpoC 764098 c.729A>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 764278 c.909A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 764317 c.948C>G synonymous_variant 0.16 rifampicin
rpoC 764365 c.996C>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764387 c.1018T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 764405 c.1036A>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764431 c.1062G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764434 c.1065A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764446 c.1077T>C synonymous_variant 0.17 rifampicin
rpoC 764449 c.1080G>C synonymous_variant 0.16 rifampicin
rpoC 764458 c.1089G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764461 c.1092A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 764497 c.1128A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764500 c.1131C>G synonymous_variant 0.17 rifampicin
rpoC 764521 c.1152T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764536 c.1167G>C synonymous_variant 0.17 rifampicin
rpoC 764539 c.1170C>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 764548 c.1179G>A synonymous_variant 0.16 rifampicin
rpoC 764554 c.1185C>T synonymous_variant 0.17 rifampicin
rpoC 764575 c.1206T>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764626 c.1257C>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 764668 c.1299C>T synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 764752 c.1383G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764764 c.1395T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764809 c.1440C>T synonymous_variant 0.17 rifampicin Not assoc w R
rpoC 764815 c.1446A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 764833 c.1464A>G synonymous_variant 0.18 rifampicin
rpoC 764872 c.1503A>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 764923 c.1554A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 765478 c.2109T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 765547 c.2178C>A synonymous_variant 0.23 rifampicin
rpoC 765556 c.2187G>C synonymous_variant 0.22 rifampicin
rpoC 765562 c.2193G>C synonymous_variant 0.21 rifampicin
rpoC 765583 c.2214G>T synonymous_variant 0.19 rifampicin
rpoC 765628 c.2259G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 765700 c.2331T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 765734 c.2365T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 765784 c.2415C>G synonymous_variant 0.16 rifampicin
rpoC 765787 c.2418C>T synonymous_variant 0.16 rifampicin
rpoC 765793 c.2424C>G synonymous_variant 0.16 rifampicin
rpoC 765796 c.2427C>T synonymous_variant 0.16 rifampicin
rpoC 765811 c.2442T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 765835 c.2466C>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 765883 c.2514C>G synonymous_variant 0.2 rifampicin
rpoC 765886 c.2517C>G synonymous_variant 0.22 rifampicin
rpoC 765892 c.2523T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 765952 c.2583G>C synonymous_variant 0.2 rifampicin
rpoC 765967 c.2598C>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 765979 c.2610C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 765994 c.2625A>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 766381 c.3012C>T synonymous_variant 0.18 rifampicin
rpoC 766384 c.3015A>G synonymous_variant 0.18 rifampicin
rpoC 766408 c.3039C>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 766426 c.3057C>T synonymous_variant 0.24 rifampicin
rpoC 766486 c.3117A>G synonymous_variant 0.22 rifampicin
rpoC 766543 c.3174C>T synonymous_variant 0.2 rifampicin
rpoC 766573 c.3204T>C synonymous_variant 0.2 rifampicin
rpoC 766585 c.3216T>C synonymous_variant 0.21 rifampicin
rpoC 766594 c.3225G>C synonymous_variant 0.2 rifampicin
rpoC 766607 p.Ile1080Leu missense_variant 0.21 rifampicin
rpoC 766657 c.3288A>G synonymous_variant 0.17 rifampicin
rpoC 766672 c.3303T>C synonymous_variant 0.18 rifampicin
rpoC 766726 c.3357T>C synonymous_variant 0.21 rifampicin
rpoC 766765 c.3396A>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 766774 c.3405T>C synonymous_variant 0.25 rifampicin
rpoC 766801 c.3432C>T synonymous_variant 0.15 rifampicin
rpoC 766804 c.3435A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 766864 c.3495G>C synonymous_variant 0.17 rifampicin
rpoC 766963 c.3594T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 766972 c.3603G>C synonymous_variant 0.18 rifampicin
rpoC 766996 c.3627C>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 767002 c.3633G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 767033 c.3664_3666delTCGinsAGT synonymous_variant 0.23 rifampicin
rpoC 767059 c.3690T>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 767062 c.3693C>A synonymous_variant 0.28 rifampicin
rpoC 767098 c.3729T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 767119 c.3750A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 767200 c.3831G>A synonymous_variant 0.17 rifampicin
rpoC 767221 c.3852C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 767233 c.3864T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
mmpL5 775639 p.Ile948Val missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
mmpL5 776100 p.Thr794Ile missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
mmpL5 776182 p.Asp767Asn missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R
mmpS5 779615 c.-710C>G upstream_gene_variant 0.99 clofazimine
bedaquiline
rpsL 781395 c.-165T>C upstream_gene_variant 0.98 streptomycin Not assoc w R
rpsL 781609 p.Ser17Thr missense_variant 0.15 streptomycin
rpsL 781628 c.69T>C synonymous_variant 0.17 streptomycin Not assoc w R - Interim
rpsL 781649 c.90T>C synonymous_variant 0.2 streptomycin
rpsL 781655 c.96T>C synonymous_variant 0.19 streptomycin
rpsL 781715 c.156T>C synonymous_variant 0.18 streptomycin
rpsL 781718 c.159C>G synonymous_variant 0.18 streptomycin
rpsL 781728 c.169T>C synonymous_variant 0.21 streptomycin
rpsL 781760 c.201T>C synonymous_variant 0.24 streptomycin
rpsL 781808 c.249C>T synonymous_variant 0.21 streptomycin
rpsL 781832 c.273T>C synonymous_variant 0.21 streptomycin
rpsL 781868 c.309T>C synonymous_variant 0.17 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.17 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.17 streptomycin
rpsL 781898 c.339A>T synonymous_variant 0.17 streptomycin
rpsL 781916 c.357T>C synonymous_variant 0.17 streptomycin
rpsL 781929 p.Gly124Ser missense_variant 0.17 streptomycin Uncertain significance
rplC 800567 c.-242A>G upstream_gene_variant 0.2 linezolid
rplC 800579 c.-230C>T upstream_gene_variant 0.2 linezolid
rplC 800582 c.-227C>G upstream_gene_variant 0.2 linezolid
rplC 800612 c.-197A>G upstream_gene_variant 0.18 linezolid
rplC 800618 c.-191T>C upstream_gene_variant 0.18 linezolid
rplC 800648 c.-161A>C upstream_gene_variant 0.19 linezolid
rplC 800693 c.-116A>C upstream_gene_variant 0.21 linezolid
rplC 800714 c.-95C>T upstream_gene_variant 0.18 linezolid
rplC 800715 c.-94A>C upstream_gene_variant 0.18 linezolid
rplC 800723 c.-86C>G upstream_gene_variant 0.18 linezolid
rplC 800844 c.36T>C synonymous_variant 0.15 linezolid
rplC 801210 c.402T>C synonymous_variant 0.15 linezolid
rplC 801312 c.504G>C synonymous_variant 0.18 linezolid
rplC 801339 c.531T>G synonymous_variant 0.15 linezolid
rplC 801348 c.540T>G synonymous_variant 0.15 linezolid
rplC 801357 c.549T>C synonymous_variant 0.15 linezolid
Rv1129c 1254562 c.-28T>C upstream_gene_variant 1.0 moxifloxacin Not assoc w R
levofloxacin Not assoc w R
rifampicin Not assoc w R
isoniazid Not assoc w R
fbiC 1303545 c.615A>G synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1304625 c.1695C>T synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1304784 c.1854T>G synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1304787 c.1857T>C synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1304799 c.1869G>C synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1304832 c.1902C>T synonymous_variant 0.22 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1304856 c.1926C>G synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1304893 p.Gly655Ser missense_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1304915 p.Asp662Gly missense_variant 0.16 clofazimine
pretomanid
delamanid
sigE 1364889 c.477A>G synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
Rv1258c 1406760 c.580_581insC frameshift_variant 0.99 streptomycin Uncertain significance
isoniazid Uncertain significance
pyrazinamide Uncertain significance
atpE 1461219 c.175T>C synonymous_variant 0.16 bedaquiline
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471970 n.125G>A non_coding_transcript_exon_variant 0.18 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472040 n.195T>C non_coding_transcript_exon_variant 0.21 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472053 n.211_212delGC non_coding_transcript_exon_variant 0.23 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472061 n.216A>T non_coding_transcript_exon_variant 0.25 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472075 n.230A>G non_coding_transcript_exon_variant 0.27 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472969 n.1124A>G non_coding_transcript_exon_variant 0.22 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472977 n.1132G>C non_coding_transcript_exon_variant 0.14 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472978 n.1133T>C non_coding_transcript_exon_variant 0.21 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473123 n.1278delAinsTT non_coding_transcript_exon_variant 0.24 streptomycin
kanamycin
capreomycin
amikacin
rrl 1473758 n.101G>T non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid
rrl 1473806 n.149C>T non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473877 n.220G>A non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1473887 n.230T>A non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1473888 n.231T>A non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473995 n.338G>T non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1474009 n.352A>G non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
rrl 1474083 n.426C>T non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid
rrl 1474103 n.446A>T non_coding_transcript_exon_variant 0.29 capreomycin
linezolid
rrl 1474140 n.483C>T non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474632 n.975G>T non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474639 n.982G>A non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474673 n.1016T>C non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474717 n.1060A>T non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>A non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474831 n.1174A>G non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid
rrl 1475061 n.1404C>T non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid
rrl 1475266 n.1609T>C non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475273 n.1616T>G non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1475289 n.1632G>A non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1475290 n.1633A>G non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1475291 n.1634A>C non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475315 n.1658A>T non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475333 n.1676T>C non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1475355 n.1698C>T non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475369 n.1712G>A non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1475402 n.1746T>A non_coding_transcript_exon_variant 0.15 capreomycin
linezolid
rrl 1475429 n.1772G>A non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475608 n.1951T>C non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid
rrl 1475638 n.1981C>T non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1475659 n.2002G>A non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475881 n.2224T>C non_coding_transcript_exon_variant 0.15 capreomycin
linezolid
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.28 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476035 n.2378G>A non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1476049 n.2392C>T non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476086 n.2429G>A non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476089 n.2432T>C non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1476095 n.2438C>G non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1476115 n.2458T>C non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476251 n.2594T>C non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476297 n.2640C>T non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476299 n.2642C>T non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476580 n.2923G>A non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1476597 n.2940G>A non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid
rrl 1476619 n.2962C>T non_coding_transcript_exon_variant 0.24 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476726 n.3069A>G non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
rrl 1476732 n.3075T>C non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
inhA 1674870 c.669T>C synonymous_variant 0.2 ethionamide
isoniazid
inhA 1674903 c.702T>C synonymous_variant 0.15 ethionamide
isoniazid
inhA 1674904 p.Ala235Pro missense_variant 0.15 ethionamide
isoniazid
rpsA 1833589 c.48A>T synonymous_variant 0.19 pyrazinamide
rpsA 1833724 c.183C>G synonymous_variant 0.21 pyrazinamide
rpsA 1833727 c.186G>C synonymous_variant 0.2 pyrazinamide
rpsA 1833745 c.204G>C synonymous_variant 0.22 pyrazinamide
rpsA 1833802 c.261A>G synonymous_variant 0.21 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.19 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.2 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.21 pyrazinamide
rpsA 1833874 c.333T>C synonymous_variant 0.22 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.25 pyrazinamide
rpsA 1833949 c.408T>C synonymous_variant 0.24 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.21 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.22 pyrazinamide
rpsA 1834030 c.489C>G synonymous_variant 0.2 pyrazinamide
rpsA 1834051 c.510G>A synonymous_variant 0.2 pyrazinamide
rpsA 1834177 c.636A>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
rpsA 1834249 c.708T>C synonymous_variant 0.2 pyrazinamide
rpsA 1834261 c.720A>G synonymous_variant 0.21 pyrazinamide Not assoc w R - Interim
rpsA 1834306 c.765T>C synonymous_variant 0.17 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
rpsA 1834366 c.825A>G synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
rpsA 1834396 c.855G>C synonymous_variant 0.22 pyrazinamide
rpsA 1834411 c.870T>C synonymous_variant 0.21 pyrazinamide
rpsA 1834417 c.876G>C synonymous_variant 0.2 pyrazinamide
rpsA 1834451 c.910T>C synonymous_variant 0.2 pyrazinamide
rpsA 1834456 c.915T>G synonymous_variant 0.19 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.2 pyrazinamide
rpsA 1834489 c.948T>C synonymous_variant 0.21 pyrazinamide
rpsA 1834495 c.954G>A synonymous_variant 0.2 pyrazinamide
rpsA 1834528 c.987T>C synonymous_variant 0.24 pyrazinamide
rpsA 1834546 c.1005T>C synonymous_variant 0.23 pyrazinamide
rpsA 1834609 c.1068T>C synonymous_variant 0.22 pyrazinamide
rpsA 1834615 c.1074C>T synonymous_variant 0.21 pyrazinamide
rpsA 1834633 c.1092A>G synonymous_variant 0.22 pyrazinamide
rpsA 1834639 c.1098T>C synonymous_variant 0.22 pyrazinamide
rpsA 1834690 c.1149T>C synonymous_variant 0.17 pyrazinamide
tsnR 1853574 c.-32T>C upstream_gene_variant 1.0 linezolid
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
katG 2154724 p.Arg463Leu missense_variant 1.0 isoniazid Not assoc w R
PPE35 2167926 p.Leu896Ser missense_variant 1.0 pyrazinamide Not assoc w R
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
kasA 2517941 c.-174C>G upstream_gene_variant 0.17 isoniazid
kasA 2518561 c.447T>C synonymous_variant 0.15 isoniazid
kasA 2518567 c.453G>T synonymous_variant 0.15 isoniazid
kasA 2518672 c.558G>C synonymous_variant 0.2 isoniazid
kasA 2518711 c.597A>G synonymous_variant 0.23 isoniazid
kasA 2518747 c.633C>G synonymous_variant 0.22 isoniazid
kasA 2518783 c.669T>C synonymous_variant 0.2 isoniazid
kasA 2518795 c.681C>G synonymous_variant 0.16 isoniazid
kasA 2518825 c.711T>C synonymous_variant 0.18 isoniazid
kasA 2518864 c.750G>C synonymous_variant 0.17 isoniazid
kasA 2518885 c.771T>C synonymous_variant 0.19 isoniazid
kasA 2518906 c.792A>G synonymous_variant 0.17 isoniazid
kasA 2518939 c.825T>C synonymous_variant 0.16 isoniazid
kasA 2518942 c.828T>C synonymous_variant 0.16 isoniazid
ahpC 2726348 c.156T>C synonymous_variant 0.15 isoniazid
Rv2477c 2783194 c.849A>G synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783329 c.714G>A synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783332 c.711T>C synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783359 c.684G>A synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783374 c.669G>C synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783395 c.648T>C synonymous_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783410 c.633G>C synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783422 c.621T>C synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783428 c.615C>T synonymous_variant 0.18 ethambutol
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783461 c.582T>C synonymous_variant 0.15 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783674 c.369T>C synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783683 c.360A>G synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783700 p.Thr115Ser missense_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783751 p.Ile98Val missense_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783857 c.186C>G synonymous_variant 0.15 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783860 c.183T>C synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783883 c.160T>C synonymous_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783884 c.159T>A synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783920 c.123G>C synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783926 c.117C>G synonymous_variant 0.15 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783956 c.87T>C synonymous_variant 0.27 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783971 c.72G>C synonymous_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783992 c.51T>C synonymous_variant 0.22 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2784477 c.-435T>C upstream_gene_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
thyX 3067316 c.630A>G synonymous_variant 0.17 para-aminosalicylic_acid
thyX 3067325 c.621A>G synonymous_variant 0.18 para-aminosalicylic_acid
thyX 3067373 c.573C>G synonymous_variant 0.19 para-aminosalicylic_acid
thyX 3067874 c.72C>G synonymous_variant 0.17 para-aminosalicylic_acid
thyA 3073932 c.540C>T synonymous_variant 0.19 para-aminosalicylic_acid
thyA 3073977 c.495A>G synonymous_variant 0.2 para-aminosalicylic_acid
thyA 3073989 c.483T>C synonymous_variant 0.22 para-aminosalicylic_acid
thyA 3074031 c.441T>C synonymous_variant 0.19 para-aminosalicylic_acid
thyA 3074037 c.435C>G synonymous_variant 0.18 para-aminosalicylic_acid
thyA 3074053 p.Arg140Gln missense_variant 0.17 para-aminosalicylic_acid
thyA 3074056 p.Glu139Pro missense_variant 0.16 para-aminosalicylic_acid
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
Rv3236c 3612813 p.Thr102Ala missense_variant 0.97 pyrazinamide Not assoc w R - Interim
mtrB 3625065 p.Met517Leu missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
mtrB 3625729 c.885A>G synonymous_variant 0.16 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625755 p.Ala287Thr missense_variant 0.17 bedaquiline
rifampicin Uncertain significance
mtrB 3626562 p.Pro18Ser missense_variant 0.99 bedaquiline Uncertain significance
rifampicin Not assoc w R
mtrA 3626804 c.546A>G synonymous_variant 0.16 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3626846 c.504G>A synonymous_variant 0.19 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626852 c.-239G>A upstream_gene_variant 0.19 bedaquiline
rifampicin
mtrB 3626857 c.-244T>C upstream_gene_variant 0.18 bedaquiline
rifampicin
mtrB 3626866 c.-253T>C upstream_gene_variant 0.2 bedaquiline
rifampicin
mtrB 3626890 c.-277T>C upstream_gene_variant 0.2 bedaquiline
rifampicin
mtrA 3626912 c.438T>C synonymous_variant 0.19 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626972 c.-359A>G upstream_gene_variant 0.16 bedaquiline
rifampicin
mtrB 3627071 c.-458G>C upstream_gene_variant 0.21 bedaquiline
rifampicin
mtrA 3627098 c.252A>C synonymous_variant 0.21 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627104 c.-491C>G upstream_gene_variant 0.2 bedaquiline
rifampicin
mtrB 3627182 c.-569T>C upstream_gene_variant 0.16 bedaquiline
rifampicin
mtrA 3627190 c.160T>C synonymous_variant 0.16 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627203 c.-590C>G upstream_gene_variant 0.18 bedaquiline
rifampicin
mtrA 3627242 c.108C>T synonymous_variant 0.18 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627266 c.-653A>G upstream_gene_variant 0.16 bedaquiline
rifampicin
mtrB 3627272 c.-659G>T upstream_gene_variant 0.16 bedaquiline
rifampicin
mtrB 3627287 c.-674C>G upstream_gene_variant 0.15 bedaquiline
rifampicin
fbiA 3640298 c.-245A>G upstream_gene_variant 0.14 clofazimine
pretomanid
delamanid
rpoA 3877587 c.921A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3877613 p.Ile299Val missense_variant 0.18 rifampicin
rpoA 3877668 c.840A>G synonymous_variant 0.15 rifampicin
rpoA 3877764 c.744C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3877770 c.738A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3877776 c.732T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoA 3877782 c.726T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3877839 c.669G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3877875 c.633T>G synonymous_variant 0.16 rifampicin
rpoA 3877909 p.Asn200Ser missense_variant 0.16 rifampicin
rpoA 3877986 c.522G>C synonymous_variant 0.22 rifampicin
rpoA 3877989 c.519A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoA 3878001 c.507A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoA 3878022 c.486T>C synonymous_variant 0.18 rifampicin
rpoA 3878025 c.483C>T synonymous_variant 0.17 rifampicin
rpoA 3878028 c.480G>C synonymous_variant 0.17 rifampicin
rpoA 3878031 c.477T>C synonymous_variant 0.17 rifampicin
rpoA 3878106 c.402G>C synonymous_variant 0.18 rifampicin
rpoA 3878118 c.390T>C synonymous_variant 0.18 rifampicin
rpoA 3878157 c.351C>G synonymous_variant 0.23 rifampicin
rpoA 3878163 c.345C>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoA 3878172 c.336G>C synonymous_variant 0.15 rifampicin
rpoA 3878193 c.315T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoA 3878202 c.306G>C synonymous_variant 0.16 rifampicin
rpoA 3878217 c.291A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoA 3878247 c.261G>C synonymous_variant 0.23 rifampicin
rpoA 3878256 c.252G>C synonymous_variant 0.28 rifampicin
rpoA 3878262 c.246C>T synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoA 3878271 c.237T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoA 3878283 p.Glu75Asp missense_variant 0.25 rifampicin Uncertain significance
rpoA 3878295 c.213A>G synonymous_variant 0.23 rifampicin
rpoA 3878298 c.210A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoA 3878331 c.177A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoA 3878334 c.174T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoA 3878337 c.171T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoA 3878406 c.102G>T synonymous_variant 0.19 rifampicin
rpoA 3878442 c.66G>C synonymous_variant 0.16 rifampicin
rpoA 3878454 c.54A>G synonymous_variant 0.15 rifampicin
rpoA 3878809 c.-302T>C upstream_gene_variant 0.17 rifampicin
rpoA 3878853 c.-346G>A upstream_gene_variant 0.22 rifampicin
rpoA 3878878 c.-371T>C upstream_gene_variant 0.23 rifampicin Uncertain significance
rpoA 3878909 c.-402A>G upstream_gene_variant 0.22 rifampicin
rpoA 3878914 c.-407T>C upstream_gene_variant 0.2 rifampicin Uncertain significance
rpoA 3878938 c.-431T>C upstream_gene_variant 0.17 rifampicin
rpoA 3879088 c.-581A>C upstream_gene_variant 0.22 rifampicin
rpoA 3879094 c.-587T>C upstream_gene_variant 0.23 rifampicin
rpoA 3879121 c.-614T>G upstream_gene_variant 0.25 rifampicin
rpoA 3879148 c.-641G>C upstream_gene_variant 0.15 rifampicin
rpoA 3879154 c.-647T>C upstream_gene_variant 0.26 rifampicin
rpoA 3879160 c.-653A>G upstream_gene_variant 0.26 rifampicin
rpoA 3879172 c.-665C>T upstream_gene_variant 0.16 rifampicin
rpoA 3879184 c.-677G>A upstream_gene_variant 0.16 rifampicin
rpoA 3879222 c.-715T>C upstream_gene_variant 0.16 rifampicin
clpC1 4038278 c.2427T>C synonymous_variant 0.21 pyrazinamide
clpC1 4038314 c.2391T>G synonymous_variant 0.15 pyrazinamide
clpC1 4038350 c.2355C>G synonymous_variant 0.21 pyrazinamide
clpC1 4038356 c.2349T>C synonymous_variant 0.2 pyrazinamide
clpC1 4038359 c.2346A>G synonymous_variant 0.2 pyrazinamide
clpC1 4038368 c.2337T>C synonymous_variant 0.18 pyrazinamide
clpC1 4038403 c.2302T>C synonymous_variant 0.16 pyrazinamide Not assoc w R - Interim
clpC1 4038456 p.Val750Glu missense_variant 0.14 pyrazinamide
clpC1 4038519 p.Arg729Gln missense_variant 0.2 pyrazinamide
clpC1 4038530 p.Glu725Asp missense_variant 0.2 pyrazinamide
clpC1 4038536 c.2169C>T synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
clpC1 4038596 c.2109A>G synonymous_variant 0.2 pyrazinamide
clpC1 4038790 c.1915C>T synonymous_variant 0.21 pyrazinamide Not assoc w R - Interim
clpC1 4038812 c.1893T>C synonymous_variant 0.22 pyrazinamide
clpC1 4038878 c.1827A>G synonymous_variant 0.22 pyrazinamide Not assoc w R - Interim
clpC1 4038908 c.1797C>G synonymous_variant 0.19 pyrazinamide
clpC1 4038914 c.1791G>C synonymous_variant 0.19 pyrazinamide
clpC1 4038923 c.1782A>G synonymous_variant 0.18 pyrazinamide
clpC1 4038953 c.1752A>G synonymous_variant 0.2 pyrazinamide
clpC1 4038956 c.1749T>C synonymous_variant 0.2 pyrazinamide
clpC1 4038965 c.1740T>C synonymous_variant 0.18 pyrazinamide
clpC1 4038971 c.1734T>C synonymous_variant 0.17 pyrazinamide
clpC1 4038974 c.1731T>C synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
clpC1 4038980 c.1725C>T synonymous_variant 0.18 pyrazinamide
clpC1 4038989 c.1716T>C synonymous_variant 0.17 pyrazinamide
clpC1 4039022 c.1683A>G synonymous_variant 0.18 pyrazinamide
clpC1 4039085 c.1620A>G synonymous_variant 0.17 pyrazinamide
clpC1 4039097 c.1608G>C synonymous_variant 0.16 pyrazinamide
clpC1 4039103 c.1602T>C synonymous_variant 0.16 pyrazinamide
clpC1 4039106 c.1599G>C synonymous_variant 0.16 pyrazinamide
clpC1 4039112 c.1593C>G synonymous_variant 0.17 pyrazinamide
clpC1 4039121 c.1584T>C synonymous_variant 0.17 pyrazinamide
clpC1 4039133 c.1572C>G synonymous_variant 0.17 pyrazinamide
clpC1 4039142 c.1563A>G synonymous_variant 0.17 pyrazinamide
clpC1 4039145 c.1560G>C synonymous_variant 0.17 pyrazinamide
clpC1 4039172 c.1533A>G synonymous_variant 0.17 pyrazinamide
clpC1 4039183 c.1522T>C synonymous_variant 0.17 pyrazinamide
clpC1 4039226 c.1479T>C synonymous_variant 0.18 pyrazinamide Not assoc w R - Interim
clpC1 4039286 c.1419T>C synonymous_variant 0.19 pyrazinamide
clpC1 4039292 c.1413C>T synonymous_variant 0.19 pyrazinamide
clpC1 4039319 c.1386T>C synonymous_variant 0.18 pyrazinamide Not assoc w R - Interim
clpC1 4039391 c.1314T>G synonymous_variant 0.18 pyrazinamide
clpC1 4039409 c.1296T>C synonymous_variant 0.17 pyrazinamide
clpC1 4039412 c.1293T>G synonymous_variant 0.16 pyrazinamide
clpC1 4039463 c.1242C>G synonymous_variant 0.16 pyrazinamide
clpC1 4039466 c.1239T>C synonymous_variant 0.15 pyrazinamide
clpC1 4039469 c.1236T>C synonymous_variant 0.16 pyrazinamide
clpC1 4039481 c.1224T>C synonymous_variant 0.2 pyrazinamide
clpC1 4039517 c.1188C>G synonymous_variant 0.19 pyrazinamide
clpC1 4039610 c.1095G>C synonymous_variant 0.17 pyrazinamide
clpC1 4039616 c.1089G>C synonymous_variant 0.17 pyrazinamide
clpC1 4039661 c.1044T>C synonymous_variant 0.23 pyrazinamide
clpC1 4039694 c.1011G>C synonymous_variant 0.2 pyrazinamide
clpC1 4039724 c.981A>G synonymous_variant 0.2 pyrazinamide
clpC1 4039751 c.954A>G synonymous_variant 0.18 pyrazinamide
clpC1 4039820 c.885T>C synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
clpC1 4039826 c.879C>G synonymous_variant 0.17 pyrazinamide
clpC1 4039831 c.874T>C synonymous_variant 0.17 pyrazinamide
clpC1 4039850 c.855T>C synonymous_variant 0.2 pyrazinamide
clpC1 4039865 c.840T>C synonymous_variant 0.2 pyrazinamide
clpC1 4039898 c.807C>G synonymous_variant 0.17 pyrazinamide
clpC1 4039931 c.774T>C synonymous_variant 0.19 pyrazinamide
clpC1 4039952 c.753T>C synonymous_variant 0.18 pyrazinamide
clpC1 4039958 c.747G>C synonymous_variant 0.17 pyrazinamide
clpC1 4040021 c.684A>C synonymous_variant 0.16 pyrazinamide Not assoc w R - Interim
clpC1 4040033 c.672G>C synonymous_variant 0.17 pyrazinamide
clpC1 4040105 c.600C>G synonymous_variant 0.17 pyrazinamide
clpC1 4040480 c.225T>C synonymous_variant 0.15 pyrazinamide Not assoc w R - Interim
clpC1 4040522 c.183T>C synonymous_variant 0.15 pyrazinamide Not assoc w R - Interim
clpC1 4040551 c.154T>C synonymous_variant 0.15 pyrazinamide Not assoc w R - Interim
embC 4240486 c.624G>A synonymous_variant 0.16 ethambutol
embC 4240489 c.627A>G synonymous_variant 0.16 ethambutol
embC 4240495 c.633T>C synonymous_variant 0.16 ethambutol
embC 4240783 c.921G>C synonymous_variant 0.17 ethambutol
embC 4241140 c.1278A>G synonymous_variant 0.18 ethambutol Not assoc w R - Interim
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
embA 4243460 c.228C>T synonymous_variant 0.99 ethambutol Not assoc w R
embA 4244885 c.1653A>G synonymous_variant 0.16 ethambutol
embB 4246567 c.54G>T synonymous_variant 1.0 ethambutol Not assoc w R - Interim
embB 4247470 c.957T>C synonymous_variant 0.27 ethambutol
embB 4247497 c.984T>C synonymous_variant 0.24 ethambutol
embB 4247500 c.987C>G synonymous_variant 0.24 ethambutol
embB 4247512 c.999T>C synonymous_variant 0.23 ethambutol
embB 4247554 c.1041T>C synonymous_variant 0.19 ethambutol
embB 4247590 c.1077A>G synonymous_variant 0.15 ethambutol Not assoc w R - Interim
embB 4248055 c.1542G>C synonymous_variant 0.18 ethambutol
embB 4248064 c.1551G>C synonymous_variant 0.18 ethambutol Not assoc w R - Interim
embB 4248070 c.1557T>C synonymous_variant 0.19 ethambutol
embB 4248130 c.1617G>C synonymous_variant 0.2 ethambutol
embB 4248142 c.1629T>C synonymous_variant 0.19 ethambutol
embB 4248206 p.Ser565Gly missense_variant 0.19 ethambutol Uncertain significance
embB 4248217 c.1704C>G synonymous_variant 0.17 ethambutol
embB 4248220 c.1707A>G synonymous_variant 0.18 ethambutol Not assoc w R - Interim
embB 4248233 c.1720C>T synonymous_variant 0.17 ethambutol
embB 4248277 c.1764G>C synonymous_variant 0.18 ethambutol
embB 4248280 c.1767C>G synonymous_variant 0.18 ethambutol
embB 4248316 c.1803C>G synonymous_variant 0.18 ethambutol
embB 4248319 c.1806A>G synonymous_variant 0.18 ethambutol
aftB 4267647 p.Asp397Gly missense_variant 0.86 ethambutol Not assoc w R
ubiA 4269222 c.612T>G synonymous_variant 0.16 ethambutol Not assoc w R - Interim
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 capreomycin
amikacin
kanamycin
gid 4407588 c.615A>G synonymous_variant 0.99 streptomycin Not assoc w R
gid 4407927 p.Glu92Asp missense_variant 1.0 streptomycin Not assoc w R