Run ID: SRR29096246
Sample name:
Date: 2025-02-11T18:40:05.318532
Number of reads: 110828
Percentage reads mapped: 24.56
Median coverage: 0.0
Strain: La1.7;lineage4.9
Spoligotype:
Drug-resistance: Sensitive
| Lineage | Family | RDs | Frequency |
|---|---|---|---|
| La1.7 | M.bovis | None | 0.06 |
| lineage4 | Euro-American | None | 1.0 |
| lineage4.9 | Euro-American (H37Rv-like) | None | 0.98 |
| lineage6.2.1 | West-Africa 2 | RD702 | 0.05 |
| Drug | Resistance | Supporting mutations | WHO confidence | Comment |
|---|---|---|---|---|
| rifampicin | ||||
| isoniazid | ||||
| ethambutol | ||||
| pyrazinamide | ||||
| streptomycin | ||||
| fluoroquinolones | ||||
| moxifloxacin | ||||
| ofloxacin | ||||
| levofloxacin | ||||
| ciprofloxacin | ||||
| aminoglycosides | ||||
| amikacin | ||||
| capreomycin | ||||
| kanamycin | ||||
| cycloserine | ||||
| ethionamide | ||||
| clofazimine | ||||
| para-aminosalicylic_acid | ||||
| delamanid | ||||
| bedaquiline | ||||
| linezolid |
| Gene | Chromosome position | Mutation | Type | Estimated fraction | Drugs | Confidence | Comment |
|---|
| Gene | Chromosome position | Mutation | Type | Estimated fraction | Drugs | Confidence |
|---|---|---|---|---|---|---|
| gyrA | 6589 | c.-713G>A | upstream_gene_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| gyrA | 6598 | c.-704C>G | upstream_gene_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| gyrA | 6610 | c.-692C>G | upstream_gene_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| gyrA | 6613 | c.-689A>G | upstream_gene_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| gyrA | 6616 | c.-686A>G | upstream_gene_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| gyrA | 6619 | c.-683T>C | upstream_gene_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| gyrA | 6622 | c.-680C>T | upstream_gene_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| gyrA | 6634 | c.-668T>C | upstream_gene_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| gyrA | 6637 | c.-665T>G | upstream_gene_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| gyrA | 6640 | c.-662A>C | upstream_gene_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| gyrA | 6643 | c.-659A>G | upstream_gene_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| gyrA | 6649 | c.-653T>C | upstream_gene_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| gyrA | 6673 | c.-629A>C | upstream_gene_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| gyrA | 6676 | c.-626T>G | upstream_gene_variant | 0.95 | levofloxacin | |
| moxifloxacin | ||||||
| gyrB | 6680 | c.1441C>T | synonymous_variant | 1.0 | levofloxacin | Not assoc w R - Interim |
| moxifloxacin | Not assoc w R - Interim | |||||
| gyrA | 6700 | c.-602T>C | upstream_gene_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| gyrA | 6703 | c.-599G>C | upstream_gene_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| gyrA | 6709 | c.-593A>G | upstream_gene_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| gyrA | 6712 | c.-590G>C | upstream_gene_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| gyrA | 6724 | c.-578G>C | upstream_gene_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| gyrA | 6730 | c.-572A>G | upstream_gene_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| gyrA | 6742 | c.-560A>G | upstream_gene_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| gyrB | 6745 | c.1506T>C | synonymous_variant | 1.0 | levofloxacin | Not assoc w R - Interim |
| moxifloxacin | Not assoc w R - Interim | |||||
| gyrA | 6760 | c.-542G>C | upstream_gene_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| gyrA | 6766 | c.-536G>C | upstream_gene_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| gyrA | 7480 | p.Phe60Tyr | missense_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| gyrA | 7484 | c.183T>C | synonymous_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| gyrA | 7496 | c.195C>G | synonymous_variant | 1.0 | levofloxacin | Not assoc w R - Interim |
| moxifloxacin | Not assoc w R - Interim | |||||
| gyrA | 7499 | c.198G>C | synonymous_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| gyrA | 7514 | c.213C>G | synonymous_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| gyrA | 7520 | c.219G>C | synonymous_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| gyrA | 7523 | c.222C>G | synonymous_variant | 1.0 | levofloxacin | Not assoc w R - Interim |
| moxifloxacin | Not assoc w R - Interim | |||||
| gyrA | 7532 | c.231T>C | synonymous_variant | 1.0 | levofloxacin | Not assoc w R - Interim |
| moxifloxacin | Not assoc w R - Interim | |||||
| gyrA | 7541 | c.240C>G | synonymous_variant | 1.0 | levofloxacin | Not assoc w R - Interim |
| moxifloxacin | Not assoc w R - Interim | |||||
| gyrA | 7585 | p.Ser95Thr | missense_variant | 1.0 | levofloxacin | Not assoc w R |
| moxifloxacin | Not assoc w R | |||||
| gyrA | 7595 | c.294C>G | synonymous_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| mshA | 575821 | c.474G>C | synonymous_variant | 1.0 | isoniazid | |
| ethionamide | ||||||
| mshA | 575842 | c.495G>C | synonymous_variant | 1.0 | isoniazid | |
| ethionamide | ||||||
| mshA | 575845 | c.498C>T | synonymous_variant | 1.0 | isoniazid | Not assoc w R - Interim |
| ethionamide | ||||||
| mshA | 575878 | c.531A>C | synonymous_variant | 1.0 | isoniazid | |
| ethionamide | ||||||
| mshA | 575884 | c.537G>C | synonymous_variant | 1.0 | isoniazid | |
| ethionamide | ||||||
| mshA | 575893 | c.546C>G | synonymous_variant | 1.0 | isoniazid | |
| ethionamide | ||||||
| mshA | 575905 | c.558G>C | synonymous_variant | 1.0 | isoniazid | |
| ethionamide | ||||||
| mshA | 575917 | p.Asp190Glu | missense_variant | 1.0 | isoniazid | |
| ethionamide | ||||||
| mshA | 575920 | c.573C>G | synonymous_variant | 1.0 | isoniazid | |
| ethionamide | ||||||
| mshA | 575924 | p.Gly193Ser | missense_variant | 1.0 | isoniazid | |
| ethionamide | ||||||
| mshA | 575944 | c.597T>C | synonymous_variant | 1.0 | isoniazid | |
| ethionamide | ||||||
| mshA | 575945 | p.Thr200Ala | missense_variant | 1.0 | isoniazid | |
| ethionamide | ||||||
| mshA | 575950 | c.603C>G | synonymous_variant | 1.0 | isoniazid | |
| ethionamide | ||||||
| ccsA | 620328 | c.438G>C | synonymous_variant | 1.0 | kanamycin | |
| capreomycin | ||||||
| amikacin | ||||||
| ccsA | 620337 | c.447C>G | synonymous_variant | 1.0 | kanamycin | |
| capreomycin | ||||||
| amikacin | ||||||
| ccsA | 620349 | c.459A>C | synonymous_variant | 1.0 | kanamycin | |
| capreomycin | ||||||
| amikacin | ||||||
| ccsA | 620358 | c.468C>G | synonymous_variant | 1.0 | kanamycin | |
| capreomycin | ||||||
| amikacin | ||||||
| ccsA | 620362 | p.Ala158Ser | missense_variant | 0.92 | kanamycin | |
| capreomycin | ||||||
| amikacin | ||||||
| ccsA | 620365 | p.Asn159His | missense_variant | 1.0 | kanamycin | |
| capreomycin | ||||||
| amikacin | ||||||
| ccsA | 620373 | c.483C>G | synonymous_variant | 1.0 | kanamycin | |
| capreomycin | ||||||
| amikacin | ||||||
| ccsA | 620376 | c.486G>C | synonymous_variant | 1.0 | kanamycin | |
| capreomycin | ||||||
| amikacin | ||||||
| ccsA | 620412 | c.522T>C | synonymous_variant | 1.0 | kanamycin | |
| capreomycin | ||||||
| amikacin | ||||||
| ccsA | 620415 | c.525T>C | synonymous_variant | 1.0 | kanamycin | Not assoc w R - Interim |
| capreomycin | Not assoc w R - Interim | |||||
| amikacin | Not assoc w R - Interim | |||||
| ccsA | 620418 | c.528G>C | synonymous_variant | 1.0 | kanamycin | |
| capreomycin | ||||||
| amikacin | ||||||
| ccsA | 620421 | c.531G>C | synonymous_variant | 1.0 | kanamycin | |
| capreomycin | ||||||
| amikacin | ||||||
| ccsA | 620424 | c.534G>C | synonymous_variant | 1.0 | kanamycin | |
| capreomycin | ||||||
| amikacin | ||||||
| ccsA | 620436 | c.546T>C | synonymous_variant | 1.0 | kanamycin | |
| capreomycin | ||||||
| amikacin | ||||||
| ccsA | 620439 | c.549T>G | synonymous_variant | 1.0 | kanamycin | |
| capreomycin | ||||||
| amikacin | ||||||
| ccsA | 620445 | c.555A>G | synonymous_variant | 1.0 | kanamycin | |
| capreomycin | ||||||
| amikacin | ||||||
| ccsA | 620451 | c.561G>C | synonymous_variant | 1.0 | kanamycin | |
| capreomycin | ||||||
| amikacin | ||||||
| ccsA | 620456 | p.Ala189Gly | missense_variant | 1.0 | kanamycin | |
| capreomycin | ||||||
| amikacin | ||||||
| ccsA | 620649 | c.759A>G | synonymous_variant | 1.0 | kanamycin | |
| capreomycin | ||||||
| amikacin | ||||||
| ccsA | 620652 | c.762C>G | synonymous_variant | 1.0 | kanamycin | |
| capreomycin | ||||||
| amikacin | ||||||
| ccsA | 620694 | c.804C>G | synonymous_variant | 1.0 | kanamycin | |
| capreomycin | ||||||
| amikacin | ||||||
| ccsA | 620698 | p.Val270Ile | missense_variant | 1.0 | kanamycin | |
| capreomycin | ||||||
| amikacin | ||||||
| ccsA | 620712 | c.822G>C | synonymous_variant | 1.0 | kanamycin | |
| capreomycin | ||||||
| amikacin | ||||||
| ccsA | 620718 | c.828G>C | synonymous_variant | 1.0 | kanamycin | |
| capreomycin | ||||||
| amikacin | ||||||
| ccsA | 620721 | c.831G>C | synonymous_variant | 1.0 | kanamycin | |
| capreomycin | ||||||
| amikacin | ||||||
| ccsA | 620733 | c.843G>C | synonymous_variant | 1.0 | kanamycin | |
| capreomycin | ||||||
| amikacin | ||||||
| ccsA | 620739 | c.849A>C | synonymous_variant | 1.0 | kanamycin | |
| capreomycin | ||||||
| amikacin | ||||||
| ccsA | 620742 | c.852G>C | synonymous_variant | 1.0 | kanamycin | |
| capreomycin | ||||||
| amikacin | ||||||
| ccsA | 620748 | c.858T>C | synonymous_variant | 1.0 | kanamycin | |
| capreomycin | ||||||
| amikacin | ||||||
| ccsA | 620754 | c.864G>C | synonymous_variant | 1.0 | kanamycin | |
| capreomycin | ||||||
| amikacin | ||||||
| ccsA | 620778 | c.888T>C | synonymous_variant | 1.0 | kanamycin | |
| capreomycin | ||||||
| amikacin | ||||||
| ccsA | 620787 | c.897C>G | synonymous_variant | 1.0 | kanamycin | |
| capreomycin | ||||||
| amikacin | ||||||
| ccsA | 620793 | c.903G>C | synonymous_variant | 1.0 | kanamycin | |
| capreomycin | ||||||
| amikacin | ||||||
| rpoB | 760460 | c.654G>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoB | 760475 | c.669A>G | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoB | 760481 | c.675G>T | synonymous_variant | 1.0 | rifampicin | |
| rpoB | 760484 | c.678A>G | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoB | 760487 | c.681G>C | synonymous_variant | 1.0 | rifampicin | |
| rpoB | 760715 | c.909C>T | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoB | 760724 | c.918T>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoB | 761570 | c.1764T>C | synonymous_variant | 0.9 | rifampicin | Not assoc w R - Interim |
| rpoB | 761579 | c.1773G>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoB | 761612 | c.1806G>T | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoB | 761615 | c.1809A>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoB | 761633 | c.1827G>C | synonymous_variant | 1.0 | rifampicin | |
| rpoB | 761636 | c.1830G>T | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoB | 761648 | c.1842T>C | synonymous_variant | 1.0 | rifampicin | |
| rpoB | 762047 | c.2241G>A | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoB | 762053 | c.2247T>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoB | 762065 | c.2259T>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoB | 762068 | c.2262C>T | synonymous_variant | 1.0 | rifampicin | |
| rpoB | 762083 | c.2277T>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoB | 762086 | c.2280G>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoB | 762128 | c.2322G>C | synonymous_variant | 1.0 | rifampicin | |
| rpoB | 762131 | c.2325C>G | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 763921 | c.552G>C | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 763930 | c.561G>A | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 763940 | p.Ala191Ser | missense_variant | 1.0 | rifampicin | Uncertain significance |
| rpoC | 763945 | c.576T>C | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 763947 | p.Ala193Val | missense_variant | 1.0 | rifampicin | Uncertain significance |
| rpoC | 763951 | c.582G>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoC | 763960 | c.591T>G | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoC | 763969 | c.600C>T | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoC | 763978 | c.609C>T | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 763987 | c.618C>T | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 763991 | p.Ile208Leu | missense_variant | 1.0 | rifampicin | |
| rpoC | 765871 | c.2502T>C | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 765875 | p.Val836Ile | missense_variant | 1.0 | rifampicin | Uncertain significance |
| rpoC | 765886 | c.2517C>G | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 765904 | c.2535C>G | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoC | 765937 | c.2568T>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoC | 765940 | c.2571A>T | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoC | 765946 | c.2577C>T | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 765947 | c.2578T>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoC | 765962 | c.2593T>C | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 765967 | c.2598C>T | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoC | 765979 | c.2610C>G | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoC | 765982 | c.2613C>T | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoC | 765994 | c.2625A>T | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoC | 766003 | c.2634G>C | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 766012 | c.2643C>G | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoC | 766021 | c.2652G>C | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 766027 | c.2658G>C | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 766315 | c.2946C>G | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 766321 | c.2952C>G | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 766348 | c.2979A>G | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoC | 766363 | c.2994G>C | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 766369 | c.3000C>G | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 766384 | c.3015A>G | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 766393 | c.3024C>G | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 766423 | c.3054T>C | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 766426 | c.3057C>T | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 766429 | c.3060C>G | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 766447 | c.3078T>C | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 766459 | c.3090G>C | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 766483 | c.3114G>C | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 766486 | c.3117A>C | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 766492 | c.3123T>G | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 766493 | p.Gly1042Asn | missense_variant | 1.0 | rifampicin | |
| rpoC | 766516 | c.3147C>G | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 766517 | p.Thr1050Ser | missense_variant | 1.0 | rifampicin | |
| rpoC | 766525 | c.3156G>T | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 766528 | c.3159T>C | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 766530 | p.Arg1054Gln | missense_variant | 1.0 | rifampicin | |
| rpoC | 766534 | c.3165C>G | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 766537 | c.3168G>A | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 766540 | p.Asp1057Glu | missense_variant | 1.0 | rifampicin | |
| rpoC | 766543 | c.3174C>T | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 766549 | c.3180G>T | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 766568 | p.Val1067Ile | missense_variant | 1.0 | rifampicin | |
| rpoC | 766573 | c.3204T>G | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoC | 766585 | c.3216T>C | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 766607 | p.Ile1080Leu | missense_variant | 1.0 | rifampicin | |
| rpoC | 766618 | c.3249G>T | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 766624 | c.3255G>C | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 766630 | c.3261G>T | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 766634 | p.Phe1089Ile | missense_variant | 1.0 | rifampicin | |
| rpoC | 766645 | c.3276A>G | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 766658 | p.Arg1097Gly | missense_variant | 1.0 | rifampicin | |
| rpoC | 766666 | c.3297C>G | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 766672 | c.3303T>C | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 766678 | c.3309C>T | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoC | 766685 | p.Glu1106Gln | missense_variant | 1.0 | rifampicin | |
| rpoC | 766690 | c.3321G>C | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 766694 | p.Gln1109Asp | missense_variant | 1.0 | rifampicin | |
| rpoC | 766702 | c.3333G>C | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 766708 | c.3339A>G | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 766711 | c.3342C>T | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoC | 766720 | c.3351C>T | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 766726 | c.3357T>C | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 766732 | c.3363G>C | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 766738 | c.3369G>T | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 766747 | c.3378C>T | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 766750 | c.3381C>G | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 766753 | c.3384C>T | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 766765 | c.3396A>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoC | 766774 | c.3405T>C | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 766776 | p.Arg1136His | missense_variant | 1.0 | rifampicin | |
| rpoC | 766798 | c.3429C>G | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoC | 766804 | c.3435A>G | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoC | 766807 | c.3438T>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoC | 766837 | c.3468G>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoC | 766843 | c.3474T>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoC | 766846 | c.3477C>G | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoC | 766858 | c.3489C>T | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoC | 766861 | c.3492G>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| mmpL5 | 775841 | c.2640G>C | synonymous_variant | 1.0 | bedaquiline | |
| clofazimine | ||||||
| mmpL5 | 775856 | c.2625T>C | synonymous_variant | 1.0 | bedaquiline | |
| clofazimine | ||||||
| mmpL5 | 775865 | c.2616T>C | synonymous_variant | 1.0 | bedaquiline | |
| clofazimine | ||||||
| mmpL5 | 775898 | c.2583G>A | synonymous_variant | 0.53 | bedaquiline | |
| clofazimine | ||||||
| mmpL5 | 775907 | c.2574C>G | synonymous_variant | 0.5 | bedaquiline | |
| clofazimine | ||||||
| mmpL5 | 775913 | p.Ala856Ser | missense_variant | 0.5 | bedaquiline | |
| clofazimine | ||||||
| mmpL5 | 775916 | c.2565T>G | synonymous_variant | 1.0 | bedaquiline | |
| clofazimine | ||||||
| mmpL5 | 775937 | c.2544G>C | synonymous_variant | 0.45 | bedaquiline | |
| clofazimine | ||||||
| mmpL5 | 775940 | c.2541C>T | synonymous_variant | 0.55 | bedaquiline | |
| clofazimine | ||||||
| mmpL5 | 775943 | c.2538C>G | synonymous_variant | 0.45 | bedaquiline | |
| clofazimine | ||||||
| mmpL5 | 775946 | c.2535C>G | synonymous_variant | 0.55 | bedaquiline | |
| clofazimine | ||||||
| mmpL5 | 775951 | c.2530C>T | synonymous_variant | 1.0 | bedaquiline | |
| clofazimine | ||||||
| mmpL5 | 775964 | p.Ala839Ser | missense_variant | 0.5 | bedaquiline | |
| clofazimine | ||||||
| mmpL5 | 775975 | p.Leu836Met | missense_variant | 1.0 | bedaquiline | |
| clofazimine | ||||||
| mmpL5 | 775981 | p.Leu834Met | missense_variant | 1.0 | bedaquiline | |
| clofazimine | ||||||
| mmpL5 | 775990 | c.2491C>T | synonymous_variant | 0.6 | bedaquiline | |
| clofazimine | ||||||
| mmpL5 | 776000 | p.Leu827Ile | missense_variant | 1.0 | bedaquiline | |
| clofazimine | ||||||
| mmpL5 | 776009 | c.2472A>G | synonymous_variant | 1.0 | bedaquiline | |
| clofazimine | ||||||
| mmpL5 | 776024 | c.2457G>A | synonymous_variant | 0.6 | bedaquiline | |
| clofazimine | ||||||
| mmpL5 | 776030 | c.2451G>T | synonymous_variant | 0.6 | bedaquiline | |
| clofazimine | ||||||
| rpsL | 781628 | c.69T>C | synonymous_variant | 1.0 | streptomycin | Not assoc w R - Interim |
| rpsL | 781631 | c.72G>C | synonymous_variant | 1.0 | streptomycin | |
| rpsL | 781655 | c.96T>C | synonymous_variant | 1.0 | streptomycin | |
| rpsL | 781658 | c.99A>G | synonymous_variant | 1.0 | streptomycin | |
| rpsL | 781682 | c.123T>C | synonymous_variant | 1.0 | streptomycin | |
| rpsL | 781709 | c.150G>T | synonymous_variant | 1.0 | streptomycin | |
| rpsL | 781715 | c.156T>C | synonymous_variant | 1.0 | streptomycin | |
| rpsL | 781718 | c.159C>G | synonymous_variant | 1.0 | streptomycin | |
| rpsL | 781728 | c.169T>C | synonymous_variant | 1.0 | streptomycin | |
| rpsL | 781733 | c.174G>C | synonymous_variant | 1.0 | streptomycin | |
| rpsL | 781736 | c.177T>C | synonymous_variant | 1.0 | streptomycin | |
| rpsL | 781751 | c.192G>C | synonymous_variant | 1.0 | streptomycin | |
| rpsL | 781754 | c.195G>C | synonymous_variant | 1.0 | streptomycin | |
| rpsL | 781760 | c.201T>C | synonymous_variant | 1.0 | streptomycin | |
| rpsL | 781766 | c.207C>T | synonymous_variant | 1.0 | streptomycin | Not assoc w R - Interim |
| rpsL | 781793 | c.234G>C | synonymous_variant | 1.0 | streptomycin | |
| rpsL | 781811 | c.252C>T | synonymous_variant | 1.0 | streptomycin | |
| rpsL | 781814 | c.255C>T | synonymous_variant | 1.0 | streptomycin | |
| rpsL | 781817 | c.258G>T | synonymous_variant | 1.0 | streptomycin | |
| rpsL | 781829 | c.270G>C | synonymous_variant | 1.0 | streptomycin | |
| rpsL | 781832 | c.273T>C | synonymous_variant | 1.0 | streptomycin | |
| rpsL | 781841 | c.282C>T | synonymous_variant | 1.0 | streptomycin | |
| rpsL | 781865 | c.306G>C | synonymous_variant | 1.0 | streptomycin | |
| rpsL | 781868 | c.309T>C | synonymous_variant | 1.0 | streptomycin | |
| rpsL | 781871 | c.312G>C | synonymous_variant | 1.0 | streptomycin | |
| rpsL | 781877 | c.318T>C | synonymous_variant | 1.0 | streptomycin | |
| rpsL | 781880 | c.321C>G | synonymous_variant | 1.0 | streptomycin | |
| rpsL | 781892 | c.333A>G | synonymous_variant | 1.0 | streptomycin | |
| rpsL | 781895 | c.336G>A | synonymous_variant | 1.0 | streptomycin | |
| rpsL | 781898 | c.339A>G | synonymous_variant | 1.0 | streptomycin | |
| rpsL | 781907 | c.348T>C | synonymous_variant | 1.0 | streptomycin | |
| rpsL | 781916 | c.357T>C | synonymous_variant | 1.0 | streptomycin | |
| rpsL | 781929 | p.Gly124Ser | missense_variant | 1.0 | streptomycin | Uncertain significance |
| rplC | 800546 | c.-263T>C | upstream_gene_variant | 1.0 | linezolid | |
| rplC | 800564 | c.-245C>G | upstream_gene_variant | 1.0 | linezolid | |
| rplC | 800567 | c.-242A>G | upstream_gene_variant | 1.0 | linezolid | |
| rplC | 800570 | c.-239C>G | upstream_gene_variant | 1.0 | linezolid | |
| rplC | 800574 | c.-235_-234delGTinsAC | upstream_gene_variant | 1.0 | linezolid | |
| rplC | 800579 | c.-230C>T | upstream_gene_variant | 1.0 | linezolid | |
| rplC | 800594 | c.-215C>G | upstream_gene_variant | 1.0 | linezolid | |
| rplC | 800597 | c.-212A>G | upstream_gene_variant | 1.0 | linezolid | |
| rplC | 800600 | c.-209G>C | upstream_gene_variant | 1.0 | linezolid | |
| rplC | 800603 | c.-206G>C | upstream_gene_variant | 1.0 | linezolid | |
| rplC | 800612 | c.-197A>G | upstream_gene_variant | 1.0 | linezolid | |
| rplC | 800618 | c.-191T>C | upstream_gene_variant | 1.0 | linezolid | |
| rplC | 800633 | c.-176T>C | upstream_gene_variant | 1.0 | linezolid | |
| rplC | 800654 | c.-155T>C | upstream_gene_variant | 1.0 | linezolid | |
| rplC | 800690 | c.-119C>G | upstream_gene_variant | 1.0 | linezolid | |
| rplC | 800693 | c.-116A>G | upstream_gene_variant | 1.0 | linezolid | |
| rplC | 800715 | c.-94A>C | upstream_gene_variant | 1.0 | linezolid | |
| rplC | 800720 | c.-89T>C | upstream_gene_variant | 1.0 | linezolid | |
| rplC | 800723 | c.-86C>G | upstream_gene_variant | 1.0 | linezolid | |
| rplC | 800738 | c.-71T>C | upstream_gene_variant | 1.0 | linezolid | |
| rplC | 800744 | c.-65G>A | upstream_gene_variant | 1.0 | linezolid | |
| fbiC | 1304613 | c.1683T>C | synonymous_variant | 1.0 | pretomanid | |
| delamanid | ||||||
| clofazimine | ||||||
| fbiC | 1304628 | c.1698G>C | synonymous_variant | 1.0 | pretomanid | |
| delamanid | ||||||
| clofazimine | ||||||
| fbiC | 1304634 | c.1704C>G | synonymous_variant | 1.0 | pretomanid | |
| delamanid | ||||||
| clofazimine | ||||||
| fbiC | 1304637 | c.1707G>A | synonymous_variant | 1.0 | pretomanid | |
| delamanid | ||||||
| clofazimine | ||||||
| fbiC | 1304640 | c.1710A>C | synonymous_variant | 1.0 | pretomanid | |
| delamanid | ||||||
| clofazimine | ||||||
| fbiC | 1304646 | c.1716T>C | synonymous_variant | 1.0 | pretomanid | |
| delamanid | ||||||
| clofazimine | ||||||
| fbiC | 1304658 | c.1728C>G | synonymous_variant | 1.0 | pretomanid | |
| delamanid | ||||||
| clofazimine | ||||||
| fbiC | 1304661 | c.1731C>T | synonymous_variant | 1.0 | pretomanid | |
| delamanid | ||||||
| clofazimine | ||||||
| fbiC | 1304671 | p.Val581Thr | missense_variant | 1.0 | pretomanid | |
| delamanid | ||||||
| clofazimine | ||||||
| fbiC | 1304675 | p.Gly582Asp | missense_variant | 1.0 | pretomanid | |
| delamanid | ||||||
| clofazimine | ||||||
| fbiC | 1304679 | c.1749G>A | synonymous_variant | 1.0 | pretomanid | |
| delamanid | ||||||
| clofazimine | ||||||
| fbiC | 1304686 | p.Asp586Gln | missense_variant | 1.0 | pretomanid | |
| delamanid | ||||||
| clofazimine | ||||||
| fbiC | 1304691 | c.1761G>A | synonymous_variant | 1.0 | pretomanid | |
| delamanid | ||||||
| clofazimine | ||||||
| fbiC | 1304694 | c.1764A>G | synonymous_variant | 1.0 | pretomanid | |
| delamanid | ||||||
| clofazimine | ||||||
| fbiC | 1304703 | c.1773C>G | synonymous_variant | 1.0 | pretomanid | |
| delamanid | ||||||
| clofazimine | ||||||
| fbiC | 1304724 | c.1794A>G | synonymous_variant | 1.0 | pretomanid | |
| delamanid | Not assoc w R - Interim | |||||
| clofazimine | Not assoc w R - Interim | |||||
| fbiC | 1304727 | c.1797A>G | synonymous_variant | 1.0 | pretomanid | |
| delamanid | ||||||
| clofazimine | ||||||
| atpE | 1461080 | c.36C>T | synonymous_variant | 1.0 | bedaquiline | |
| atpE | 1461107 | c.63C>G | synonymous_variant | 1.0 | bedaquiline | |
| atpE | 1461132 | p.Val30Ile | missense_variant | 1.0 | bedaquiline | |
| atpE | 1461149 | c.105T>G | synonymous_variant | 1.0 | bedaquiline | |
| atpE | 1461153 | p.Ser37Ala | missense_variant | 1.0 | bedaquiline | Uncertain significance |
| atpE | 1461158 | c.114T>C | synonymous_variant | 1.0 | bedaquiline | |
| atpE | 1461159 | p.Val39Ile | missense_variant | 1.0 | bedaquiline | Uncertain significance |
| atpE | 1461167 | c.123G>C | synonymous_variant | 1.0 | bedaquiline | |
| atpE | 1461170 | c.126A>G | synonymous_variant | 1.0 | bedaquiline | |
| atpE | 1461179 | c.135G>C | synonymous_variant | 1.0 | bedaquiline | |
| atpE | 1461182 | c.138A>G | synonymous_variant | 1.0 | bedaquiline | |
| atpE | 1461185 | c.141G>T | synonymous_variant | 0.95 | bedaquiline | |
| atpE | 1461188 | c.144G>C | synonymous_variant | 1.0 | bedaquiline | |
| atpE | 1461197 | c.153A>C | synonymous_variant | 1.0 | bedaquiline | |
| atpE | 1461212 | c.168C>G | synonymous_variant | 1.0 | bedaquiline | |
| atpE | 1461219 | c.175T>C | synonymous_variant | 1.0 | bedaquiline | |
| atpE | 1461224 | c.180T>C | synonymous_variant | 1.0 | bedaquiline | |
| rpsA | 1833772 | c.231C>T | synonymous_variant | 1.0 | pyrazinamide | |
| rpsA | 1833778 | c.237C>T | synonymous_variant | 1.0 | pyrazinamide | |
| rpsA | 1833781 | c.240T>G | synonymous_variant | 1.0 | pyrazinamide | |
| rpsA | 1833790 | c.249T>C | synonymous_variant | 1.0 | pyrazinamide | |
| rpsA | 1833799 | c.258C>G | synonymous_variant | 1.0 | pyrazinamide | |
| rpsA | 1833811 | c.270G>C | synonymous_variant | 1.0 | pyrazinamide | |
| rpsA | 1833829 | c.288A>G | synonymous_variant | 1.0 | pyrazinamide | |
| rpsA | 1833832 | c.291G>A | synonymous_variant | 1.0 | pyrazinamide | |
| rpsA | 1833838 | c.297G>C | synonymous_variant | 1.0 | pyrazinamide | |
| rpsA | 1833841 | c.300C>G | synonymous_variant | 1.0 | pyrazinamide | |
| rpsA | 1833847 | c.306C>G | synonymous_variant | 1.0 | pyrazinamide | |
| rpsA | 1833856 | c.315A>G | synonymous_variant | 1.0 | pyrazinamide | |
| rpsA | 1833859 | c.318C>T | synonymous_variant | 1.0 | pyrazinamide | |
| rpsA | 1833862 | c.321G>A | synonymous_variant | 1.0 | pyrazinamide | |
| rpsA | 1833874 | c.333T>C | synonymous_variant | 1.0 | pyrazinamide | |
| rpsA | 1833892 | c.351G>A | synonymous_variant | 1.0 | pyrazinamide | |
| kasA | 2517941 | c.-174C>G | upstream_gene_variant | 1.0 | isoniazid | |
| kasA | 2517953 | c.-162C>T | upstream_gene_variant | 1.0 | isoniazid | |
| kasA | 2517959 | c.-156C>T | upstream_gene_variant | 1.0 | isoniazid | |
| kasA | 2517974 | c.-141T>C | upstream_gene_variant | 1.0 | isoniazid | |
| kasA | 2518534 | c.420G>C | synonymous_variant | 1.0 | isoniazid | |
| kasA | 2518564 | c.450C>G | synonymous_variant | 1.0 | isoniazid | |
| kasA | 2518570 | c.456G>C | synonymous_variant | 1.0 | isoniazid | |
| kasA | 2518573 | c.459G>C | synonymous_variant | 1.0 | isoniazid | |
| kasA | 2518574 | p.Ile154Ala | missense_variant | 1.0 | isoniazid | |
| kasA | 2518583 | p.Gln157Glu | missense_variant | 1.0 | isoniazid | |
| kasA | 2518588 | c.474T>G | synonymous_variant | 1.0 | isoniazid | |
| kasA | 2518591 | c.477G>C | synonymous_variant | 1.0 | isoniazid | |
| kasA | 2518606 | c.492G>C | synonymous_variant | 1.0 | isoniazid | |
| kasA | 2518609 | p.Met165Ile | missense_variant | 1.0 | isoniazid | |
| kasA | 2518624 | c.510C>G | synonymous_variant | 1.0 | isoniazid | |
| kasA | 2518627 | c.513T>C | synonymous_variant | 1.0 | isoniazid | |
| kasA | 2518633 | c.519G>C | synonymous_variant | 1.0 | isoniazid | |
| kasA | 2518642 | c.528A>G | synonymous_variant | 1.0 | isoniazid | |
| kasA | 2518645 | c.531G>C | synonymous_variant | 1.0 | isoniazid | |
| kasA | 2518657 | c.543G>A | synonymous_variant | 1.0 | isoniazid | |
| kasA | 2518664 | p.Gln184Ser | missense_variant | 1.0 | isoniazid | |
| kasA | 2518672 | c.558G>C | synonymous_variant | 1.0 | isoniazid | |
| kasA | 2518681 | c.567C>T | synonymous_variant | 1.0 | isoniazid | |
| kasA | 2518688 | p.Val192Phe | missense_variant | 1.0 | isoniazid | |
| kasA | 2518714 | c.600A>C | synonymous_variant | 1.0 | isoniazid | |
| kasA | 2518715 | p.Pro201Gly | missense_variant | 1.0 | isoniazid | |
| kasA | 2518732 | c.618C>G | synonymous_variant | 1.0 | isoniazid | |
| kasA | 2518747 | c.633C>G | synonymous_variant | 1.0 | isoniazid | |
| kasA | 2518756 | c.642G>C | synonymous_variant | 1.0 | isoniazid | |
| kasA | 2518759 | c.645C>G | synonymous_variant | 1.0 | isoniazid | |
| kasA | 2518783 | c.669T>G | synonymous_variant | 1.0 | isoniazid | |
| kasA | 2518787 | p.Arg225Lys | missense_variant | 1.0 | isoniazid | |
| kasA | 2518795 | c.681C>G | synonymous_variant | 1.0 | isoniazid | |
| kasA | 2518811 | p.Asp233Asn | missense_variant | 1.0 | isoniazid | |
| Rv2477c | 2782987 | c.1056C>G | synonymous_variant | 1.0 | kanamycin | |
| levofloxacin | ||||||
| moxifloxacin | ||||||
| streptomycin | ||||||
| rifampicin | ||||||
| ethambutol | ||||||
| amikacin | ||||||
| Rv2477c | 2783002 | c.1041T>C | synonymous_variant | 1.0 | kanamycin | |
| levofloxacin | ||||||
| moxifloxacin | ||||||
| streptomycin | ||||||
| rifampicin | ||||||
| ethambutol | ||||||
| amikacin | ||||||
| Rv2477c | 2783005 | c.1038C>T | synonymous_variant | 1.0 | kanamycin | |
| levofloxacin | ||||||
| moxifloxacin | ||||||
| streptomycin | Not assoc w R - Interim | |||||
| rifampicin | Not assoc w R - Interim | |||||
| ethambutol | Not assoc w R - Interim | |||||
| amikacin | ||||||
| Rv2477c | 2783013 | c.1030T>C | synonymous_variant | 0.93 | kanamycin | Not assoc w R - Interim |
| levofloxacin | Not assoc w R - Interim | |||||
| moxifloxacin | Not assoc w R - Interim | |||||
| streptomycin | Not assoc w R - Interim | |||||
| rifampicin | Not assoc w R - Interim | |||||
| ethambutol | Not assoc w R - Interim | |||||
| amikacin | Not assoc w R - Interim | |||||
| Rv2477c | 2783014 | p.Ser343Thr | missense_variant | 0.93 | kanamycin | |
| levofloxacin | ||||||
| moxifloxacin | ||||||
| streptomycin | ||||||
| rifampicin | ||||||
| ethambutol | ||||||
| amikacin | ||||||
| Rv2477c | 2783020 | c.1023G>C | synonymous_variant | 1.0 | kanamycin | |
| levofloxacin | ||||||
| moxifloxacin | ||||||
| streptomycin | ||||||
| rifampicin | ||||||
| ethambutol | ||||||
| amikacin | ||||||
| Rv2477c | 2783040 | p.Ala335Thr | missense_variant | 1.0 | kanamycin | Uncertain significance |
| levofloxacin | Uncertain significance | |||||
| moxifloxacin | Uncertain significance | |||||
| streptomycin | Uncertain significance | |||||
| rifampicin | Uncertain significance | |||||
| ethambutol | Uncertain significance | |||||
| amikacin | Uncertain significance | |||||
| Rv2477c | 2783044 | c.999G>T | synonymous_variant | 1.0 | kanamycin | |
| levofloxacin | ||||||
| moxifloxacin | ||||||
| streptomycin | ||||||
| rifampicin | ||||||
| ethambutol | ||||||
| amikacin | ||||||
| Rv2477c | 2783047 | p.Asp332Glu | missense_variant | 1.0 | kanamycin | |
| levofloxacin | ||||||
| moxifloxacin | ||||||
| streptomycin | ||||||
| rifampicin | Uncertain significance | |||||
| ethambutol | Uncertain significance | |||||
| amikacin | ||||||
| Rv2477c | 2783051 | p.Tyr331Phe | missense_variant | 1.0 | kanamycin | |
| levofloxacin | ||||||
| moxifloxacin | ||||||
| streptomycin | ||||||
| rifampicin | ||||||
| ethambutol | ||||||
| amikacin | ||||||
| Rv2477c | 2783053 | c.990C>T | synonymous_variant | 1.0 | kanamycin | |
| levofloxacin | ||||||
| moxifloxacin | ||||||
| streptomycin | ||||||
| rifampicin | ||||||
| ethambutol | ||||||
| amikacin | ||||||
| Rv2477c | 2783059 | c.984T>C | synonymous_variant | 1.0 | kanamycin | |
| levofloxacin | ||||||
| moxifloxacin | ||||||
| streptomycin | ||||||
| rifampicin | ||||||
| ethambutol | ||||||
| amikacin | ||||||
| Rv2477c | 2783068 | p.Asp325Glu | missense_variant | 1.0 | kanamycin | |
| levofloxacin | ||||||
| moxifloxacin | ||||||
| streptomycin | ||||||
| rifampicin | ||||||
| ethambutol | ||||||
| amikacin | ||||||
| Rv2477c | 2783077 | c.966T>C | synonymous_variant | 1.0 | kanamycin | |
| levofloxacin | ||||||
| moxifloxacin | ||||||
| streptomycin | ||||||
| rifampicin | ||||||
| ethambutol | ||||||
| amikacin | ||||||
| Rv2477c | 2783083 | c.960G>C | synonymous_variant | 1.0 | kanamycin | |
| levofloxacin | ||||||
| moxifloxacin | ||||||
| streptomycin | Not assoc w R - Interim | |||||
| rifampicin | Not assoc w R - Interim | |||||
| ethambutol | Not assoc w R - Interim | |||||
| amikacin | ||||||
| Rv2477c | 2783092 | c.951A>G | synonymous_variant | 1.0 | kanamycin | |
| levofloxacin | ||||||
| moxifloxacin | ||||||
| streptomycin | ||||||
| rifampicin | Not assoc w R - Interim | |||||
| ethambutol | Not assoc w R - Interim | |||||
| amikacin | ||||||
| Rv2477c | 2783095 | c.948C>G | synonymous_variant | 1.0 | kanamycin | Not assoc w R - Interim |
| levofloxacin | Not assoc w R - Interim | |||||
| moxifloxacin | Not assoc w R - Interim | |||||
| streptomycin | Not assoc w R - Interim | |||||
| rifampicin | Not assoc w R | |||||
| ethambutol | Not assoc w R - Interim | |||||
| amikacin | Not assoc w R - Interim | |||||
| Rv2477c | 2783098 | c.945C>G | synonymous_variant | 1.0 | kanamycin | |
| levofloxacin | ||||||
| moxifloxacin | ||||||
| streptomycin | ||||||
| rifampicin | ||||||
| ethambutol | ||||||
| amikacin | ||||||
| Rv2477c | 2783102 | p.Gly314Pro | missense_variant | 1.0 | kanamycin | |
| levofloxacin | ||||||
| moxifloxacin | ||||||
| streptomycin | ||||||
| rifampicin | ||||||
| ethambutol | ||||||
| amikacin | ||||||
| Rv2477c | 2783105 | p.Val313Thr | missense_variant | 1.0 | kanamycin | |
| levofloxacin | ||||||
| moxifloxacin | ||||||
| streptomycin | ||||||
| rifampicin | ||||||
| ethambutol | ||||||
| amikacin | ||||||
| Rv2477c | 2783116 | c.927T>C | synonymous_variant | 1.0 | kanamycin | |
| levofloxacin | ||||||
| moxifloxacin | ||||||
| streptomycin | ||||||
| rifampicin | ||||||
| ethambutol | ||||||
| amikacin | ||||||
| Rv2477c | 2783926 | c.117C>G | synonymous_variant | 1.0 | kanamycin | |
| levofloxacin | ||||||
| moxifloxacin | ||||||
| streptomycin | ||||||
| rifampicin | ||||||
| ethambutol | ||||||
| amikacin | ||||||
| Rv2477c | 2783938 | c.105T>C | synonymous_variant | 1.0 | kanamycin | |
| levofloxacin | ||||||
| moxifloxacin | ||||||
| streptomycin | ||||||
| rifampicin | ||||||
| ethambutol | ||||||
| amikacin | ||||||
| Rv2477c | 2783947 | c.96C>G | synonymous_variant | 1.0 | kanamycin | |
| levofloxacin | ||||||
| moxifloxacin | ||||||
| streptomycin | ||||||
| rifampicin | ||||||
| ethambutol | ||||||
| amikacin | ||||||
| Rv2477c | 2783953 | c.90G>T | synonymous_variant | 1.0 | kanamycin | |
| levofloxacin | ||||||
| moxifloxacin | ||||||
| streptomycin | ||||||
| rifampicin | ||||||
| ethambutol | ||||||
| amikacin | ||||||
| Rv2477c | 2783957 | p.Tyr29Leu | missense_variant | 1.0 | kanamycin | |
| levofloxacin | ||||||
| moxifloxacin | ||||||
| streptomycin | ||||||
| rifampicin | ||||||
| ethambutol | ||||||
| amikacin | ||||||
| Rv2477c | 2783962 | p.Ser27Asn | missense_variant | 1.0 | kanamycin | |
| levofloxacin | ||||||
| moxifloxacin | ||||||
| streptomycin | ||||||
| rifampicin | ||||||
| ethambutol | ||||||
| amikacin | ||||||
| Rv2477c | 2783967 | c.76T>C | synonymous_variant | 1.0 | kanamycin | |
| levofloxacin | ||||||
| moxifloxacin | ||||||
| streptomycin | ||||||
| rifampicin | ||||||
| ethambutol | ||||||
| amikacin | ||||||
| Rv2477c | 2783968 | p.Thr25Asn | missense_variant | 1.0 | kanamycin | |
| levofloxacin | ||||||
| moxifloxacin | ||||||
| streptomycin | ||||||
| rifampicin | ||||||
| ethambutol | ||||||
| amikacin | ||||||
| Rv2477c | 2783971 | c.72G>C | synonymous_variant | 1.0 | kanamycin | |
| levofloxacin | ||||||
| moxifloxacin | ||||||
| streptomycin | ||||||
| rifampicin | ||||||
| ethambutol | ||||||
| amikacin | ||||||
| Rv2477c | 2783980 | c.63C>T | synonymous_variant | 1.0 | kanamycin | |
| levofloxacin | ||||||
| moxifloxacin | ||||||
| streptomycin | ||||||
| rifampicin | ||||||
| ethambutol | ||||||
| amikacin | ||||||
| Rv2477c | 2783986 | c.57G>C | synonymous_variant | 1.0 | kanamycin | |
| levofloxacin | ||||||
| moxifloxacin | ||||||
| streptomycin | ||||||
| rifampicin | ||||||
| ethambutol | ||||||
| amikacin | ||||||
| Rv2477c | 2783992 | c.51T>C | synonymous_variant | 1.0 | kanamycin | Not assoc w R - Interim |
| levofloxacin | Not assoc w R - Interim | |||||
| moxifloxacin | ||||||
| streptomycin | Not assoc w R - Interim | |||||
| rifampicin | Not assoc w R - Interim | |||||
| ethambutol | Not assoc w R - Interim | |||||
| amikacin | ||||||
| Rv2477c | 2784016 | p.Lys9Arg | missense_variant | 1.0 | kanamycin | |
| levofloxacin | ||||||
| moxifloxacin | ||||||
| streptomycin | ||||||
| rifampicin | ||||||
| ethambutol | ||||||
| amikacin | ||||||
| Rv2477c | 2784034 | c.9G>A | synonymous_variant | 1.0 | kanamycin | Not assoc w R - Interim |
| levofloxacin | Not assoc w R - Interim | |||||
| moxifloxacin | Not assoc w R - Interim | |||||
| streptomycin | Not assoc w R - Interim | |||||
| rifampicin | Not assoc w R - Interim | |||||
| ethambutol | Not assoc w R - Interim | |||||
| amikacin | Not assoc w R - Interim | |||||
| mtrB | 3625720 | c.894G>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| bedaquiline | ||||||
| mtrB | 3625729 | c.885A>G | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| bedaquiline | ||||||
| lpqB | 3625735 | c.-825C>G | upstream_gene_variant | 1.0 | rifampicin | |
| bedaquiline | ||||||
| mtrB | 3625747 | c.867G>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| bedaquiline | ||||||
| mtrB | 3625755 | p.Ala287Thr | missense_variant | 1.0 | rifampicin | Uncertain significance |
| bedaquiline | ||||||
| lpqB | 3625762 | c.-852A>C | upstream_gene_variant | 1.0 | rifampicin | |
| bedaquiline | ||||||
| mtrB | 3625765 | p.Ser283Gln | missense_variant | 1.0 | rifampicin | |
| bedaquiline | ||||||
| mtrB | 3625806 | c.808A>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| bedaquiline | ||||||
| rpoA | 3878217 | c.291A>G | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoA | 3878244 | c.264G>A | synonymous_variant | 1.0 | rifampicin | |
| rpoA | 3878253 | c.255G>C | synonymous_variant | 1.0 | rifampicin | |
| rpoA | 3878256 | c.252G>C | synonymous_variant | 1.0 | rifampicin | |
| rpoA | 3878271 | c.237T>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoA | 3878283 | p.Glu75Asp | missense_variant | 1.0 | rifampicin | Uncertain significance |
| rpoA | 3878292 | c.216T>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoA | 3878298 | c.210A>G | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoA | 3878301 | c.207C>G | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoA | 3878313 | c.195G>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoA | 3878322 | c.186A>G | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoA | 3878331 | c.177A>G | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoA | 3878337 | c.171T>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoA | 3878343 | c.165C>G | synonymous_variant | 1.0 | rifampicin | |
| embC | 4241494 | c.1632C>G | synonymous_variant | 1.0 | ethambutol | |
| embC | 4241500 | c.1638A>G | synonymous_variant | 1.0 | ethambutol | |
| embC | 4241509 | c.1647A>G | synonymous_variant | 1.0 | ethambutol | |
| embC | 4241513 | p.Ser551Thr | missense_variant | 1.0 | ethambutol | |
| embC | 4241516 | c.1654_1656delTTAinsCTG | synonymous_variant | 1.0 | ethambutol | |
| embC | 4241521 | c.1659T>C | synonymous_variant | 1.0 | ethambutol | Not assoc w R - Interim |
| embC | 4241533 | c.1671T>C | synonymous_variant | 1.0 | ethambutol | |
| embC | 4241536 | c.1674A>C | synonymous_variant | 1.0 | ethambutol | |
| embC | 4241545 | c.1683T>C | synonymous_variant | 1.0 | ethambutol | |
| embC | 4241548 | c.1686T>C | synonymous_variant | 1.0 | ethambutol | |
| embC | 4241584 | c.1722T>C | synonymous_variant | 1.0 | ethambutol |
