TB-Profiler result

Run: ERR553132
Summary

Run ID: ERR553132

Sample name:

Date: 2024-04-15T11:53:44.883642

Number of reads: 1554473

Percentage reads mapped: 87.54

Median coverage: 76.0

Strain: lineage4.1.2.1

Spoligotype:

Drug-resistance: MDR-TB

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage4.1 Euro-American None 0.98
lineage4.1.2 Euro-American None 1.0
lineage4.1.2.1 Euro-American (Haarlem) RD182 0.99
lineage4 Euro-American None 1.0
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin rpoB p.Leu452Pro Assoc w R
isoniazid katG p.Ser315Thr Assoc w R High-level resistance
ethambutol embB p.Ala356Val Uncertain significance Mutation from literature
pyrazinamide
streptomycin rpsL p.Lys88Arg Assoc w R
rrs n.462C>T Uncertain significance Mutation from literature
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
rpoB 761161 p.Leu452Pro missense_variant 0.83 rifampicin Assoc w R
rpsL 781822 p.Lys88Arg missense_variant 0.83 streptomycin Assoc w R
rrs 1472307 n.462C>T non_coding_transcript_exon_variant 0.15 streptomycin Uncertain significance Mutation from literature
katG 2155168 p.Ser315Thr missense_variant 1.0 isoniazid Assoc w R High-level resistance
embB 4247580 p.Ala356Val missense_variant 0.14 ethambutol Uncertain significance Mutation from literature
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
dnaA 1230 c.1230A>G synonymous_variant 0.17 isoniazid
dnaA 1236 c.1236C>T synonymous_variant 0.16 isoniazid
dnaA 1242 c.1242G>C synonymous_variant 0.16 isoniazid
dnaA 1245 c.1245G>C synonymous_variant 0.16 isoniazid Not assoc w R - Interim
gyrA 6982 c.-320A>C upstream_gene_variant 0.18 levofloxacin
moxifloxacin
gyrA 7007 c.-295C>T upstream_gene_variant 0.19 levofloxacin
moxifloxacin
gyrA 7010 c.-292C>T upstream_gene_variant 0.19 levofloxacin
moxifloxacin
gyrB 7023 p.Leu595Gln missense_variant 0.19 levofloxacin
moxifloxacin
gyrA 7033 c.-269G>C upstream_gene_variant 0.19 levofloxacin
moxifloxacin
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7480 p.Phe60Tyr missense_variant 0.15 levofloxacin
moxifloxacin
gyrA 7484 c.183T>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 7514 c.213C>G synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
fgd1 491591 p.Lys270Met missense_variant 0.95 clofazimine Not assoc w R
pretomanid
delamanid Uncertain significance
mshA 575679 p.Asn111Ser missense_variant 0.96 ethionamide Not assoc w R
isoniazid Not assoc w R
Rv0565c 657269 p.Ser68Pro missense_variant 0.95 ethionamide Uncertain significance
Rv0565c 657734 c.-264T>C upstream_gene_variant 0.17 ethionamide
hadA 732337 c.408G>A synonymous_variant 0.14 isoniazid
rpoB 760106 c.300G>A synonymous_variant 0.92 rifampicin Not assoc w R
rpoB 760115 c.309C>T synonymous_variant 0.92 rifampicin Not assoc w R
rpoB 760340 c.534G>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760361 c.555T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 760381 p.Thr192Met missense_variant 0.14 rifampicin
rpoB 760406 c.600G>C synonymous_variant 0.17 rifampicin
rpoB 760424 c.618C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760430 c.624T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760481 c.675G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760591 p.Val262Ala missense_variant 0.15 rifampicin
rpoB 761057 c.1251G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 761102 c.1296A>G synonymous_variant 0.15 rifampicin
rpoB 761129 c.1323G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 761132 c.1326G>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 761133 c.1327T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 761150 c.1344A>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 761153 c.1347G>C synonymous_variant 0.18 rifampicin
rpoB 761165 c.1359G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 761180 c.1374A>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 761189 c.1383T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 761195 c.1389G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 761207 c.1401C>T synonymous_variant 0.18 rifampicin
rpoB 761213 c.1407G>C synonymous_variant 0.17 rifampicin
rpoB 761219 c.1413G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761249 c.1443A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 762989 c.-381G>C upstream_gene_variant 0.2 rifampicin
rpoB 762995 c.3189G>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 763013 c.-357C>G upstream_gene_variant 0.21 rifampicin
rpoB 763028 c.3222T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 763034 c.3228C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 763040 c.3234C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 763070 c.3264T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 763085 c.3279C>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 763115 c.3309T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 763136 c.3330C>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 763148 c.-222G>C upstream_gene_variant 0.21 rifampicin
rpoC 763158 c.-212C>T upstream_gene_variant 0.19 rifampicin
rpoB 763166 c.3360A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 763190 c.-180C>T upstream_gene_variant 0.15 rifampicin
rpoC 764489 c.1120C>T synonymous_variant 0.16 rifampicin
rpoC 764497 c.1128A>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 764510 c.1141C>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 764521 c.1152T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 764527 c.1158C>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 764536 c.1167G>C synonymous_variant 0.16 rifampicin
rpoC 764554 c.1185C>T synonymous_variant 0.2 rifampicin
rpoC 764560 c.1191T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764566 c.1197C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764575 c.1206T>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764581 c.1212T>C synonymous_variant 0.22 rifampicin
rpoC 764593 c.1224C>T synonymous_variant 0.22 rifampicin
rpoC 764611 c.1242G>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>C synonymous_variant 0.23 rifampicin
rpoC 764651 c.1282_1284delTCGinsAGC synonymous_variant 0.23 rifampicin
rpoC 764752 c.1383G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764764 c.1395T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 764809 c.1440C>T synonymous_variant 0.15 rifampicin Not assoc w R
rpoC 764815 c.1446A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 765150 p.Gly594Glu missense_variant 0.99 rifampicin Not assoc w R
rpoC 765346 c.1977C>G synonymous_variant 0.16 rifampicin
rpoC 765349 c.1980T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 765352 c.1983G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 765404 p.Leu679Val missense_variant 0.23 rifampicin
rpoC 765409 c.2040T>C synonymous_variant 0.22 rifampicin
rpoC 765421 c.2052C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 765478 c.2109T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 765499 c.2130C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 765529 c.2160C>T synonymous_variant 0.22 rifampicin
rpoC 765541 c.2172C>G synonymous_variant 0.24 rifampicin
rpoC 765553 c.2184C>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 765556 c.2187G>C synonymous_variant 0.21 rifampicin
rpoC 765559 c.2190G>C synonymous_variant 0.21 rifampicin
rpoC 765580 c.2211G>C synonymous_variant 0.21 rifampicin
rpoC 765613 p.His748Gln missense_variant 0.18 rifampicin
rpoC 765625 c.2256C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 765631 p.Asp754Glu missense_variant 0.18 rifampicin
rpoC 765700 c.2331T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 765734 c.2365T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 765739 c.2370G>T synonymous_variant 0.17 rifampicin
rpoC 765751 c.2382C>G synonymous_variant 0.16 rifampicin
rpoC 765753 p.Asp795Ala missense_variant 0.16 rifampicin Uncertain significance
rpoC 765772 c.2403C>G synonymous_variant 0.15 rifampicin
rpoC 765787 c.2418C>T synonymous_variant 0.13 rifampicin
rpoC 765793 c.2424C>G synonymous_variant 0.14 rifampicin
rpoC 765796 c.2427C>T synonymous_variant 0.14 rifampicin
rpoC 765811 c.2442T>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 765814 c.2445A>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 765826 c.2457T>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 765835 c.2466C>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 765937 c.2568T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 765967 c.2598C>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 766096 c.2727G>C synonymous_variant 0.15 rifampicin
rpoC 766738 c.3369G>C synonymous_variant 0.15 rifampicin
rpoC 766747 c.3378C>T synonymous_variant 0.13 rifampicin
rpoC 766861 c.3492G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 766864 c.3495G>C synonymous_variant 0.25 rifampicin
rpoC 766867 c.3498C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 766882 c.3513C>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 766894 c.3525T>C synonymous_variant 0.21 rifampicin
rpoC 766900 c.3531T>C synonymous_variant 0.22 rifampicin
rpoC 766933 c.3564A>G synonymous_variant 0.19 rifampicin
rpoC 766945 c.3576A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 766963 c.3594T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 766972 c.3603G>C synonymous_variant 0.2 rifampicin
rpoC 766987 c.3618G>C synonymous_variant 0.18 rifampicin
rpoC 766996 c.3627C>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 767009 c.3640_3642delTCGinsAGC synonymous_variant 0.18 rifampicin
rpoC 767014 c.3645G>C synonymous_variant 0.18 rifampicin
rpoC 767033 c.3664_3666delTCGinsAGC synonymous_variant 0.2 rifampicin
rpoC 767059 c.3690T>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 767062 c.3693C>A synonymous_variant 0.15 rifampicin
mmpL5 775639 p.Ile948Val missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
rpsL 781276 c.-284A>C upstream_gene_variant 1.0 streptomycin
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781742 c.183C>T synonymous_variant 0.14 streptomycin
rpsL 781748 c.189C>G synonymous_variant 0.15 streptomycin
rpsL 781760 c.201T>C synonymous_variant 0.15 streptomycin
rpsL 781772 c.213C>A synonymous_variant 0.16 streptomycin
rpsL 781808 c.249C>T synonymous_variant 0.17 streptomycin
rpsL 781811 c.252C>T synonymous_variant 0.17 streptomycin
rpsL 781832 c.273T>C synonymous_variant 0.16 streptomycin
rpsL 781838 c.279G>C synonymous_variant 0.16 streptomycin
rpsL 781841 c.282C>G synonymous_variant 0.16 streptomycin
rpsL 781865 c.306G>C synonymous_variant 0.17 streptomycin
rpsL 781868 c.309T>C synonymous_variant 0.17 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.19 streptomycin
rpsL 781877 c.318T>C synonymous_variant 0.2 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.19 streptomycin
rpsL 781898 c.339A>T synonymous_variant 0.19 streptomycin
rpsL 781916 c.357T>C synonymous_variant 0.19 streptomycin
rpsL 781929 p.Gly124Ser missense_variant 0.19 streptomycin Uncertain significance
rplC 801207 c.399C>T synonymous_variant 0.14 linezolid
Rv1129c 1254583 c.-49A>C upstream_gene_variant 1.0 moxifloxacin Uncertain significance
levofloxacin Uncertain significance
rifampicin Not assoc w R
isoniazid Not assoc w R
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472030 n.185G>T non_coding_transcript_exon_variant 0.13 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472031 n.186G>A non_coding_transcript_exon_variant 0.13 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472061 n.216A>T non_coding_transcript_exon_variant 0.14 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.14 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472300 n.455C>T non_coding_transcript_exon_variant 0.15 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472969 n.1124A>G non_coding_transcript_exon_variant 0.15 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472977 n.1132G>C non_coding_transcript_exon_variant 0.15 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472978 n.1133T>C non_coding_transcript_exon_variant 0.15 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473105 n.1260G>A non_coding_transcript_exon_variant 0.14 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.17 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.15 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473290 n.1445C>T non_coding_transcript_exon_variant 0.16 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrl 1473877 n.220G>A non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1473898 n.241C>T non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473899 n.242A>C non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473938 n.281G>A non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1473939 n.282C>T non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1473943 n.286G>T non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid
rrl 1473981 n.324G>T non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1473986 n.329T>C non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1473987 n.330G>A non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1473995 n.338G>T non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1474001 n.344C>T non_coding_transcript_exon_variant 0.25 capreomycin Not assoc w R
linezolid Not assoc w R
rrl 1474009 n.352A>G non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1474012 n.355C>T non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1474044 n.387C>T non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid
rrl 1474054 n.397T>C non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid
rrl 1474091 n.434C>T non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1474093 n.436G>T non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1474099 n.442G>A non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1474103 n.446A>T non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1474140 n.483C>T non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474181 n.524C>T non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474308 n.651G>T non_coding_transcript_exon_variant 0.13 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474823 n.1166C>T non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1474831 n.1174A>G non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid
rrl 1474904 n.1247G>A non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1474956 n.1299C>T non_coding_transcript_exon_variant 0.31 capreomycin
linezolid
rrl 1474961 n.1304T>G non_coding_transcript_exon_variant 0.32 capreomycin
linezolid
rrl 1474963 n.1306G>A non_coding_transcript_exon_variant 0.32 capreomycin
linezolid
rrl 1474964 n.1307T>C non_coding_transcript_exon_variant 0.32 capreomycin
linezolid
rrl 1474970 n.1313G>A non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1475006 n.1349A>T non_coding_transcript_exon_variant 0.36 capreomycin
linezolid
rrl 1475028 n.1371G>A non_coding_transcript_exon_variant 0.28 capreomycin
linezolid
rrl 1475061 n.1404C>T non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid
rrl 1475088 n.1431A>T non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1475199 n.1542G>A non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1475206 n.1549C>T non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid
rrl 1475209 n.1552G>C non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid
rrl 1475213 n.1556C>T non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid
rrl 1475249 n.1592T>C non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475252 n.1595C>T non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1475266 n.1609T>C non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475267 n.1610G>A non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1475275 n.1618C>T non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1475276 n.1619T>C non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1475291 n.1634A>C non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475315 n.1658A>T non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475355 n.1698C>T non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475369 n.1712G>T non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1475402 n.1745C>T non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1475419 n.1762C>T non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid
rrl 1475483 n.1826C>T non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475505 n.1848G>A non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475573 n.1916G>A non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid
rrl 1475599 n.1942A>G non_coding_transcript_exon_variant 0.16 capreomycin
linezolid Uncertain significance
rrl 1475608 n.1951T>C non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid
rrl 1475642 n.1985T>C non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1475657 n.2000A>G non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1475659 n.2002G>T non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1475761 n.2104_2106delCGCinsGT non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1475765 n.2111delG non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1476214 n.2557G>T non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476215 n.2558C>T non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476297 n.2640C>T non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476299 n.2642C>T non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid Uncertain significance
inhA 1673685 c.-517C>T upstream_gene_variant 0.16 ethionamide
isoniazid
fabG1 1673710 p.Leu91Ile missense_variant 0.16 ethionamide
isoniazid
inhA 1674759 c.558G>C synonymous_variant 0.15 ethionamide
isoniazid
rpsA 1833724 c.183C>G synonymous_variant 0.14 pyrazinamide
rpsA 1833727 c.186G>C synonymous_variant 0.14 pyrazinamide
rpsA 1834210 c.669C>T synonymous_variant 0.14 pyrazinamide
rpsA 1834249 c.708T>C synonymous_variant 0.14 pyrazinamide
rpsA 1834333 c.792C>T synonymous_variant 0.14 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 0.14 pyrazinamide Not assoc w R - Interim
rpsA 1834417 c.876G>C synonymous_variant 0.15 pyrazinamide
rpsA 1834435 c.894G>C synonymous_variant 0.15 pyrazinamide
rpsA 1834489 c.948T>C synonymous_variant 0.15 pyrazinamide
rpsA 1834513 c.972C>G synonymous_variant 0.16 pyrazinamide
rpsA 1834528 c.987T>C synonymous_variant 0.15 pyrazinamide
rpsA 1834540 c.999G>C synonymous_variant 0.17 pyrazinamide
rpsA 1834546 c.1005T>C synonymous_variant 0.15 pyrazinamide
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
kasA 2518076 c.-39C>T upstream_gene_variant 1.0 isoniazid
Rv2477c 2782876 c.1167G>C synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782882 c.1161T>C synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782912 p.Ser377Thr missense_variant 0.15 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782927 p.Thr372Glu missense_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782936 c.1107G>T synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782948 c.1095A>G synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782957 c.1086A>G synonymous_variant 0.18 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2782966 c.1077C>A synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782969 c.1074A>C synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782972 c.1071G>C synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782981 c.1062G>C synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782984 c.1059T>C synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782990 c.1053C>G synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783002 c.1041T>C synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783008 c.1035C>G synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783013 c.1030T>C synonymous_variant 0.16 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783015 p.Ser343Thr missense_variant 0.15 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783035 c.1008G>C synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783040 p.Ala335Thr missense_variant 0.18 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
kanamycin Uncertain significance
rifampicin Uncertain significance
amikacin Uncertain significance
Rv2477c 2783044 c.999G>A synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783048 p.Asp332Gly missense_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783051 p.Tyr331Phe missense_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783059 c.984T>C synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783062 c.981C>T synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783068 p.Asp325Glu missense_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783077 c.966T>C synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783092 c.951A>G synonymous_variant 0.18 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783095 c.948C>G synonymous_variant 0.18 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R
amikacin Not assoc w R - Interim
Rv2477c 2783098 c.945C>G synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783101 c.942G>T synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783116 c.927T>C synonymous_variant 0.15 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2680 2996034 c.-71G>A upstream_gene_variant 0.26 capreomycin Uncertain significance
Rv2680 2996136 p.Ser11Asn missense_variant 0.21 capreomycin
Rv2752c 3065048 c.1144C>T synonymous_variant 0.14 ethambutol Not assoc w R - Interim
moxifloxacin
levofloxacin
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
thyX 3067531 p.Ala139Thr missense_variant 0.14 para-aminosalicylic_acid
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
mtrB 3625065 p.Met517Leu missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
mtrB 3626876 c.-263A>G upstream_gene_variant 0.18 bedaquiline
rifampicin
mtrB 3626885 c.-272A>C upstream_gene_variant 0.16 bedaquiline
rifampicin
mtrB 3626890 c.-277T>C upstream_gene_variant 0.15 bedaquiline
rifampicin
mtrB 3626900 c.-287G>A upstream_gene_variant 0.17 bedaquiline
rifampicin
mtrB 3626903 c.-290T>C upstream_gene_variant 0.17 bedaquiline
rifampicin
mtrB 3626912 c.-299T>G upstream_gene_variant 0.16 bedaquiline
rifampicin
mtrB 3626927 c.-314G>C upstream_gene_variant 0.16 bedaquiline
rifampicin
mtrB 3626930 c.-317A>G upstream_gene_variant 0.15 bedaquiline
rifampicin
mtrA 3626939 c.411A>G synonymous_variant 0.15 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626942 c.-329A>C upstream_gene_variant 0.15 bedaquiline
rifampicin
mtrB 3626945 c.-332C>T upstream_gene_variant 0.16 bedaquiline
rifampicin
mtrB 3626987 c.-374C>G upstream_gene_variant 0.17 bedaquiline
rifampicin
mtrB 3627008 c.-395G>C upstream_gene_variant 0.15 bedaquiline
rifampicin
mtrB 3627011 c.-398T>G upstream_gene_variant 0.16 bedaquiline
rifampicin
rpoA 3877764 c.744C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3877770 c.738A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3877776 c.732T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3877782 c.726T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoA 3877791 c.717C>G synonymous_variant 0.22 rifampicin
rpoA 3877818 c.690A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3877839 c.669G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3877857 c.651G>A synonymous_variant 0.17 rifampicin
rpoA 3877866 c.642G>C synonymous_variant 0.17 rifampicin
rpoA 3877875 c.633T>G synonymous_variant 0.18 rifampicin
rpoA 3877878 c.630G>C synonymous_variant 0.18 rifampicin
rpoA 3877890 c.618C>T synonymous_variant 0.17 rifampicin
rpoA 3877896 c.612G>C synonymous_variant 0.18 rifampicin
rpoA 3877900 p.Ser203Asn missense_variant 0.17 rifampicin
rpoA 3877905 c.603A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoA 3877908 p.Asn200Ser missense_variant 0.16 rifampicin
rpoA 3877920 c.588G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3877926 c.582G>C synonymous_variant 0.19 rifampicin
rpoA 3877962 c.546G>C synonymous_variant 0.21 rifampicin
rpoA 3877986 c.522G>C synonymous_variant 0.23 rifampicin
rpoA 3877989 c.519A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoA 3878001 c.507A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoA 3878022 c.486T>C synonymous_variant 0.22 rifampicin
rpoA 3878028 c.480G>C synonymous_variant 0.18 rifampicin
rpoA 3878031 c.477T>C synonymous_variant 0.19 rifampicin
rpoA 3878040 c.468T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3878046 c.462T>C synonymous_variant 0.19 rifampicin
rpoA 3878055 c.453A>G synonymous_variant 0.19 rifampicin
rpoA 3878058 c.450G>T synonymous_variant 0.18 rifampicin
rpoA 3878061 c.447G>C synonymous_variant 0.18 rifampicin
rpoA 3878067 c.441C>G synonymous_variant 0.19 rifampicin
rpoA 3878070 c.438T>C synonymous_variant 0.19 rifampicin
rpoA 3878076 c.432C>T synonymous_variant 0.2 rifampicin
rpoA 3878094 c.414C>G synonymous_variant 0.18 rifampicin
rpoA 3878103 c.405A>G synonymous_variant 0.17 rifampicin
rpoA 3878106 c.402G>C synonymous_variant 0.17 rifampicin
rpoA 3878118 c.390T>C synonymous_variant 0.16 rifampicin
rpoA 3878130 c.378C>G synonymous_variant 0.15 rifampicin
rpoA 3878143 p.Gly122Asp missense_variant 0.14 rifampicin Uncertain significance
rpoA 3878271 c.237T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoA 3878284 p.Glu75Ala missense_variant 0.16 rifampicin
rpoA 3878292 c.216T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoA 3878310 c.198G>C synonymous_variant 0.15 rifampicin
rpoA 3878322 c.186A>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoA 3878331 c.177A>G synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoA 3878334 c.174T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoA 3878337 c.171T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoA 3878346 c.162T>C synonymous_variant 0.16 rifampicin
rpoA 3878364 c.144A>C synonymous_variant 0.16 rifampicin
rpoA 3878367 c.141C>G synonymous_variant 0.16 rifampicin
rpoA 3878376 c.132G>C synonymous_variant 0.16 rifampicin
rpoA 3878385 c.123C>G synonymous_variant 0.15 rifampicin
rpoA 3878388 c.120C>G synonymous_variant 0.16 rifampicin
rpoA 3878391 c.117T>C synonymous_variant 0.16 rifampicin
rpoA 3878424 c.84G>C synonymous_variant 0.16 rifampicin
rpoA 3878436 c.72A>G synonymous_variant 0.16 rifampicin
rpoA 3878442 c.66G>C synonymous_variant 0.17 rifampicin
rpoA 3878454 c.54A>C synonymous_variant 0.19 rifampicin
rpoA 3878878 c.-371T>C upstream_gene_variant 0.15 rifampicin Uncertain significance
rpoA 3878890 c.-383C>G upstream_gene_variant 0.16 rifampicin
rpoA 3878909 c.-402A>G upstream_gene_variant 0.16 rifampicin
rpoA 3878914 c.-407T>C upstream_gene_variant 0.15 rifampicin Uncertain significance
rpoA 3878917 c.-410G>A upstream_gene_variant 0.15 rifampicin Uncertain significance
rpoA 3878932 c.-425G>A upstream_gene_variant 0.15 rifampicin
rpoA 3878938 c.-431T>C upstream_gene_variant 0.17 rifampicin
rpoA 3878947 c.-440G>C upstream_gene_variant 0.16 rifampicin Uncertain significance
rpoA 3878968 c.-461T>C upstream_gene_variant 0.16 rifampicin Uncertain significance
rpoA 3878976 c.-469A>G upstream_gene_variant 0.17 rifampicin Uncertain significance
rpoA 3878986 c.-479G>C upstream_gene_variant 0.16 rifampicin
rpoA 3878998 c.-491C>G upstream_gene_variant 0.17 rifampicin Uncertain significance
rpoA 3879005 c.-499_-498delAAinsCG upstream_gene_variant 0.18 rifampicin
rpoA 3879013 c.-506A>G upstream_gene_variant 0.18 rifampicin
rpoA 3879154 c.-647T>C upstream_gene_variant 0.15 rifampicin
rpoA 3879160 c.-653A>G upstream_gene_variant 0.15 rifampicin
rpoA 3879178 c.-671T>C upstream_gene_variant 0.18 rifampicin
rpoA 3879190 c.-683C>G upstream_gene_variant 0.15 rifampicin
clpC1 4038596 c.2109A>G synonymous_variant 0.16 pyrazinamide
clpC1 4038623 c.2082A>G synonymous_variant 0.16 pyrazinamide
clpC1 4038640 p.Asp689Asn missense_variant 0.16 pyrazinamide
clpC1 4038653 c.2052C>T synonymous_variant 0.16 pyrazinamide
clpC1 4038658 p.Lys683Gln missense_variant 0.16 pyrazinamide
clpC1 4038661 p.Ser682Thr missense_variant 0.17 pyrazinamide
clpC1 4038662 c.2043T>C synonymous_variant 0.17 pyrazinamide
clpC1 4038671 c.2034T>C synonymous_variant 0.18 pyrazinamide
clpC1 4038683 c.2022T>C synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
clpC1 4038695 c.2010C>G synonymous_variant 0.17 pyrazinamide
clpC1 4038701 c.2004G>C synonymous_variant 0.16 pyrazinamide
clpC1 4038704 c.2001T>C synonymous_variant 0.15 pyrazinamide
clpC1 4038707 c.1998C>G synonymous_variant 0.16 pyrazinamide
clpC1 4038710 c.1995G>C synonymous_variant 0.16 pyrazinamide
clpC1 4038713 c.1992T>C synonymous_variant 0.16 pyrazinamide
clpC1 4038749 c.1956C>A synonymous_variant 0.19 pyrazinamide
clpC1 4038755 c.1950G>T synonymous_variant 0.18 pyrazinamide
clpC1 4038770 c.1935C>T synonymous_variant 0.18 pyrazinamide
clpC1 4038773 c.1932T>C synonymous_variant 0.18 pyrazinamide
clpC1 4038782 c.1923G>C synonymous_variant 0.18 pyrazinamide
clpC1 4038812 c.1893T>C synonymous_variant 0.18 pyrazinamide
clpC1 4038845 c.1860G>C synonymous_variant 0.19 pyrazinamide
clpC1 4038860 c.1845G>C synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
clpC1 4038878 c.1827A>G synonymous_variant 0.21 pyrazinamide Not assoc w R - Interim
clpC1 4038893 c.1812C>T synonymous_variant 0.22 pyrazinamide
clpC1 4038908 c.1797C>G synonymous_variant 0.24 pyrazinamide
clpC1 4038914 c.1791G>C synonymous_variant 0.23 pyrazinamide
clpC1 4038923 c.1780_1782delCTAinsTG frameshift_variant&synonymous_variant 0.21 pyrazinamide
clpC1 4038953 c.1752A>G synonymous_variant 0.21 pyrazinamide
clpC1 4038956 c.1749T>C synonymous_variant 0.2 pyrazinamide
clpC1 4038965 c.1740T>C synonymous_variant 0.21 pyrazinamide
clpC1 4038971 c.1734T>C synonymous_variant 0.19 pyrazinamide
clpC1 4038974 c.1731T>C synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
clpC1 4038989 c.1716T>C synonymous_variant 0.19 pyrazinamide
clpC1 4038997 c.1708T>C synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
clpC1 4039004 c.1701C>G synonymous_variant 0.18 pyrazinamide
clpC1 4039022 c.1683A>G synonymous_variant 0.16 pyrazinamide
clpC1 4039064 c.1641C>T synonymous_variant 0.16 pyrazinamide
clpC1 4039106 c.1599G>C synonymous_variant 0.15 pyrazinamide
clpC1 4039145 c.1560G>C synonymous_variant 0.15 pyrazinamide
clpC1 4039178 c.1527G>C synonymous_variant 0.14 pyrazinamide
clpC1 4039183 c.1522T>C synonymous_variant 0.16 pyrazinamide
clpC1 4039186 c.1519C>T synonymous_variant 0.16 pyrazinamide
clpC1 4039190 c.1515C>G synonymous_variant 0.16 pyrazinamide
clpC1 4039274 c.1431G>C synonymous_variant 0.15 pyrazinamide Not assoc w R - Interim
clpC1 4039850 c.855T>C synonymous_variant 0.17 pyrazinamide
clpC1 4039929 c.775_776delAGinsTC synonymous_variant 0.15 pyrazinamide
clpC1 4039937 c.768G>C synonymous_variant 0.15 pyrazinamide
clpC1 4039946 c.759A>C synonymous_variant 0.17 pyrazinamide
clpC1 4039952 c.753T>C synonymous_variant 0.17 pyrazinamide
clpC1 4039982 c.723G>A synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
clpC1 4039988 c.717C>G synonymous_variant 0.17 pyrazinamide
clpC1 4039991 c.714G>C synonymous_variant 0.17 pyrazinamide
clpC1 4040021 c.684A>C synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
clpC1 4040024 c.681A>G synonymous_variant 0.17 pyrazinamide
clpC1 4040033 c.672G>C synonymous_variant 0.18 pyrazinamide
clpC1 4040036 c.669C>G synonymous_variant 0.18 pyrazinamide
clpC1 4040090 c.613_615delTCTinsAGC synonymous_variant 0.18 pyrazinamide
clpC1 4040093 c.612C>G synonymous_variant 0.18 pyrazinamide Not assoc w R - Interim
clpC1 4040105 c.600C>G synonymous_variant 0.17 pyrazinamide
clpC1 4040147 c.558A>G synonymous_variant 0.16 pyrazinamide Not assoc w R - Interim
clpC1 4040162 c.543G>C synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
clpC1 4040165 c.540G>C synonymous_variant 0.16 pyrazinamide
clpC1 4040171 c.534C>G synonymous_variant 0.17 pyrazinamide
clpC1 4040201 c.504C>G synonymous_variant 0.15 pyrazinamide
clpC1 4040215 p.Ser164Thr missense_variant 0.14 pyrazinamide
clpC1 4040237 c.468C>T synonymous_variant 0.15 pyrazinamide
clpC1 4040246 c.459C>G synonymous_variant 0.19 pyrazinamide
clpC1 4040249 c.456A>G synonymous_variant 0.18 pyrazinamide
clpC1 4040267 c.438A>G synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
clpC1 4040273 c.432T>C synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
clpC1 4040276 c.427_429delTCCinsAGT synonymous_variant 0.17 pyrazinamide
clpC1 4040279 c.426C>G synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
clpC1 4040291 c.414G>C synonymous_variant 0.17 pyrazinamide
clpC1 4040318 c.387C>G synonymous_variant 0.15 pyrazinamide
glpK 4138646 c.1110G>C synonymous_variant 0.14 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138654 c.1102C>T synonymous_variant 0.15 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4138670 c.1086G>C synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138679 c.1075_1077delATGinsGC frameshift_variant&missense_variant 0.15 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
glpK 4138721 c.1035G>A synonymous_variant 0.17 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4138724 c.1032A>G synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138730 c.1026C>G synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139474 c.282T>C synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139477 c.279A>G synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139483 c.273C>G synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139486 c.270T>C synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139489 c.267G>T synonymous_variant 0.18 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4139494 c.262T>C synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139504 c.250_252delGATinsAC frameshift_variant&synonymous_variant 0.17 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
glpK 4139515 p.Ser81Ala missense_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139516 c.240A>G synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139524 p.Thr78Ala missense_variant 0.18 ethambutol
moxifloxacin Uncertain significance
streptomycin
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
glpK 4139526 p.Ala77Arg missense_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139537 c.219G>C synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139541 p.Ile72Thr missense_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139545 c.211T>C synonymous_variant 0.15 ethambutol
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139554 p.Ala68Ser missense_variant 0.14 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
embC 4239298 c.-565C>T upstream_gene_variant 1.0 ethambutol Not assoc w R
embC 4240726 c.864G>C synonymous_variant 0.16 ethambutol Not assoc w R - Interim
embC 4241551 c.1689A>G synonymous_variant 0.15 ethambutol
embC 4241567 p.Ile569Val missense_variant 0.18 ethambutol
embC 4241572 c.1710C>G synonymous_variant 0.17 ethambutol
embC 4241578 c.1716G>C synonymous_variant 0.17 ethambutol
embC 4241584 c.1722T>C synonymous_variant 0.2 ethambutol
embC 4241587 c.1725C>G synonymous_variant 0.2 ethambutol
embC 4241591 p.Leu577Val missense_variant 0.17 ethambutol
embC 4241611 c.1749G>C synonymous_variant 0.18 ethambutol
embC 4241614 c.1752A>C synonymous_variant 0.18 ethambutol
embC 4241626 c.1764T>C synonymous_variant 0.18 ethambutol
embC 4241657 p.Ser599Pro missense_variant 0.16 ethambutol
embC 4241665 c.1803G>C synonymous_variant 0.17 ethambutol
embC 4241671 c.1809T>C synonymous_variant 0.17 ethambutol Not assoc w R - Interim
embC 4242643 c.2781C>T synonymous_variant 0.95 ethambutol Not assoc w R
embC 4242803 p.Val981Leu missense_variant 0.97 ethambutol Not assoc w R
embB 4247566 c.1053C>A synonymous_variant 0.14 ethambutol
embB 4247587 c.1074G>A synonymous_variant 0.15 ethambutol
embB 4247588 c.1075_1077delCTAinsAC frameshift_variant&missense_variant 0.15 ethambutol
embB 4247603 c.1090C>T synonymous_variant 0.17 ethambutol
embB 4247611 c.1098G>T synonymous_variant 0.17 ethambutol Not assoc w R - Interim
embB 4247614 c.1101T>C synonymous_variant 0.17 ethambutol Not assoc w R - Interim
embB 4247629 c.1116C>G synonymous_variant 0.14 ethambutol
embB 4247632 c.1119C>G synonymous_variant 0.14 ethambutol
embB 4247887 c.1374C>T synonymous_variant 0.15 ethambutol Not assoc w R - Interim
embB 4247893 c.1380C>T synonymous_variant 0.15 ethambutol
embB 4247899 p.Met462Ile missense_variant 0.15 ethambutol
embB 4247905 c.1392G>C synonymous_variant 0.15 ethambutol Not assoc w R - Interim
embB 4247909 c.1396T>C synonymous_variant 0.15 ethambutol
embB 4247914 c.1401G>C synonymous_variant 0.15 ethambutol Not assoc w R - Interim
embB 4248172 c.1659G>C synonymous_variant 0.15 ethambutol
embB 4249568 p.Ser1019Thr missense_variant 0.14 ethambutol
embB 4249580 p.Leu1023Met missense_variant 0.14 ethambutol
embB 4249606 c.3093C>A synonymous_variant 0.14 ethambutol
embB 4249624 c.3111C>G synonymous_variant 0.14 ethambutol
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 capreomycin
amikacin
kanamycin