TB-Profiler result

Run: SRR1173118
Summary

Run ID: SRR1173118

Sample name:

Date: 2024-03-27T01:41:41.184508

Number of reads: 290867

Percentage reads mapped: 43.6

Median coverage: 7.0

Strain: lineage2.2.1

Spoligotype:

Drug-resistance: Other

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage2 East-Asian RD105 0.28
lineage2.2.1 East-Asian (Beijing) RD105;RD207;RD181 0.18
lineage2.2 East-Asian (Beijing) RD105;RD207 0.35
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol
pyrazinamide
streptomycin rrs n.462C>T Uncertain significance Mutation from literature
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
rrs 1472307 n.462C>T non_coding_transcript_exon_variant 0.71 streptomycin Uncertain significance Mutation from literature
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
dnaA 942 c.942C>G synonymous_variant 0.43 isoniazid
dnaA 945 c.945G>A synonymous_variant 0.43 isoniazid
dnaA 1137 c.1137C>G synonymous_variant 0.7 isoniazid
dnaA 1278 c.1278T>C synonymous_variant 0.5 isoniazid
dnaA 1404 c.1404T>C synonymous_variant 0.5 isoniazid
dnaA 1407 c.1407T>C synonymous_variant 0.5 isoniazid
dnaA 1413 c.1413A>C synonymous_variant 0.55 isoniazid
dnaA 1416 c.1416C>G synonymous_variant 0.5 isoniazid
dnaA 1428 c.1428C>G synonymous_variant 0.5 isoniazid
gyrB 6268 c.1029C>G synonymous_variant 0.46 levofloxacin
moxifloxacin
gyrB 6280 c.1041T>C synonymous_variant 0.4 levofloxacin
moxifloxacin
gyrA 6362 c.-940T>C upstream_gene_variant 0.47 levofloxacin
moxifloxacin
gyrB 6670 c.1431G>A synonymous_variant 0.71 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 6673 c.-629A>C upstream_gene_variant 0.71 levofloxacin
moxifloxacin
gyrA 6676 c.-626T>G upstream_gene_variant 0.73 levofloxacin
moxifloxacin
gyrA 6700 c.-602T>C upstream_gene_variant 0.85 levofloxacin
moxifloxacin
gyrA 6703 c.-599G>C upstream_gene_variant 0.83 levofloxacin
moxifloxacin
gyrA 6709 c.-593A>G upstream_gene_variant 0.82 levofloxacin
moxifloxacin
gyrB 6728 c.1489_1491delCTAinsTG frameshift_variant&stop_gained 0.82 levofloxacin Uncertain significance
moxifloxacin
gyrA 6742 c.-560A>G upstream_gene_variant 0.8 levofloxacin
moxifloxacin
gyrB 6745 c.1506T>G synonymous_variant 0.81 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6751 c.-551G>C upstream_gene_variant 0.82 levofloxacin
moxifloxacin
gyrA 6760 c.-542G>C upstream_gene_variant 0.8 levofloxacin
moxifloxacin
gyrB 6763 c.1524G>C synonymous_variant 0.79 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6775 c.1536G>C synonymous_variant 0.77 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6787 c.-515G>A upstream_gene_variant 0.67 levofloxacin
moxifloxacin
gyrB 6793 c.1554T>C synonymous_variant 0.67 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6797 p.Gly520Thr missense_variant 0.62 levofloxacin
moxifloxacin
gyrB 6811 c.1572C>T synonymous_variant 0.62 levofloxacin
moxifloxacin Not assoc w R - Interim
gyrA 8135 c.834C>G synonymous_variant 0.5 levofloxacin
moxifloxacin
gyrA 8156 c.855T>C synonymous_variant 0.53 levofloxacin
moxifloxacin
gyrA 8177 c.876A>C synonymous_variant 0.5 levofloxacin
moxifloxacin
gyrA 8198 c.897T>C synonymous_variant 0.53 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8207 c.906T>C synonymous_variant 0.53 levofloxacin
moxifloxacin
gyrA 8219 c.918T>C synonymous_variant 0.54 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8225 c.924T>C synonymous_variant 0.54 levofloxacin
moxifloxacin
gyrA 8420 c.1119T>C synonymous_variant 0.8 levofloxacin
moxifloxacin
gyrA 8597 c.1296C>G synonymous_variant 0.6 levofloxacin
moxifloxacin
gyrA 8603 c.1302A>G synonymous_variant 0.6 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8619 c.1318_1320delTTGinsCA frameshift_variant&missense_variant 0.64 levofloxacin
moxifloxacin
gyrA 8624 c.1323G>C synonymous_variant 0.69 levofloxacin
moxifloxacin
gyrA 8636 c.1335A>C synonymous_variant 0.6 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8642 c.1341A>G synonymous_variant 0.6 levofloxacin
moxifloxacin
gyrA 8672 c.1371A>G synonymous_variant 0.6 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8852 c.1551T>C synonymous_variant 0.58 levofloxacin
moxifloxacin
gyrA 8858 c.1557T>C synonymous_variant 0.5 levofloxacin
moxifloxacin
gyrA 8891 c.1590G>A synonymous_variant 0.59 levofloxacin
moxifloxacin
gyrA 8897 c.1596T>C synonymous_variant 0.62 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8903 c.1602T>C synonymous_variant 0.59 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9182 c.1881T>C synonymous_variant 0.73 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9191 c.1890G>C synonymous_variant 0.7 levofloxacin
moxifloxacin
gyrA 9200 c.1899A>G synonymous_variant 0.7 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9239 c.1938C>T synonymous_variant 0.55 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9252 p.Val651Ile missense_variant 0.62 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
fgd1 491601 c.819T>C synonymous_variant 0.67 clofazimine
pretomanid
delamanid
fgd1 491610 c.828A>G synonymous_variant 0.7 clofazimine
pretomanid
delamanid
fgd1 491616 c.834A>G synonymous_variant 0.73 clofazimine
pretomanid
delamanid
fgd1 491620 p.Ile280Val missense_variant 0.73 clofazimine
pretomanid
delamanid
ccsA 620412 c.522T>C synonymous_variant 0.8 capreomycin
amikacin
kanamycin
ccsA 620415 c.525T>C synonymous_variant 0.8 capreomycin Not assoc w R - Interim
amikacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
ccsA 620421 c.531G>C synonymous_variant 0.8 capreomycin
amikacin
kanamycin
ccsA 620424 c.534G>C synonymous_variant 0.8 capreomycin
amikacin
kanamycin
Rv0565c 657632 c.-162G>A upstream_gene_variant 0.54 ethionamide
Rv0565c 657649 c.-179G>A upstream_gene_variant 0.63 ethionamide
Rv0565c 657671 c.-201A>G upstream_gene_variant 0.67 ethionamide
Rv0565c 657678 c.-209_-208delAAinsTC upstream_gene_variant 0.69 ethionamide
Rv0565c 657689 c.-220_-219delCAinsAC upstream_gene_variant 0.69 ethionamide
Rv0565c 657701 c.-231C>G upstream_gene_variant 0.75 ethionamide
nusG 734442 c.189G>A synonymous_variant 0.57 rifampicin
nusG 734451 c.198G>C synonymous_variant 0.62 rifampicin
nusG 734457 c.204C>G synonymous_variant 0.67 rifampicin
nusG 734472 c.219T>C synonymous_variant 0.73 rifampicin
nusG 734475 c.222T>C synonymous_variant 0.73 rifampicin Not assoc w R - Interim
nusG 734499 c.246G>C synonymous_variant 0.85 rifampicin
nusG 734532 c.279A>G synonymous_variant 0.79 rifampicin Not assoc w R - Interim
nusG 734541 c.288A>G synonymous_variant 0.67 rifampicin Not assoc w R - Interim
nusG 734580 c.327T>C synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoB 760184 c.378A>G synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoB 760196 c.390C>G synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoB 760223 c.417T>C synonymous_variant 0.62 rifampicin
rpoB 760235 c.429T>C synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoB 760541 c.735G>C synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoB 760547 c.741G>C synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoB 760591 p.Val262Ala missense_variant 0.85 rifampicin
rpoB 760611 c.805T>C synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoB 761006 c.1200C>G synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoB 761036 c.1230G>C synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoB 761037 c.1231T>C synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoB 761057 c.1251G>C synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoB 761165 c.1359G>C synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoB 761180 c.1374A>C synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoB 761189 c.1383T>C synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoB 761195 c.1389G>C synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoB 761207 c.1401C>T synonymous_variant 0.71 rifampicin
rpoB 761213 c.1407G>C synonymous_variant 0.73 rifampicin
rpoB 761219 c.1413G>C synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoB 761255 c.1449T>G synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoB 761261 c.1455G>T synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoB 761306 c.1500C>G synonymous_variant 0.78 rifampicin
rpoB 761327 c.1521A>G synonymous_variant 0.79 rifampicin Not assoc w R - Interim
rpoB 761330 c.1524G>C synonymous_variant 0.79 rifampicin
rpoB 761354 c.1548C>T synonymous_variant 0.75 rifampicin
rpoB 761360 c.1554T>C synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoB 761362 p.Ser519Thr missense_variant 0.79 rifampicin
rpoB 761373 p.Val523His missense_variant 0.71 rifampicin
rpoB 761588 c.1782C>T synonymous_variant 0.62 rifampicin
rpoB 761606 c.1800C>G synonymous_variant 0.67 rifampicin
rpoB 761612 c.1806G>C synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoB 761615 c.1809A>C synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoB 761636 c.1830G>T synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoB 761906 c.2100C>G synonymous_variant 0.71 rifampicin
rpoB 761909 c.2103T>C synonymous_variant 0.71 rifampicin
rpoB 761912 c.2106T>C synonymous_variant 0.71 rifampicin
rpoB 761915 p.Asp703Glu missense_variant 0.71 rifampicin
rpoB 761916 p.Asp704Asn missense_variant 0.71 rifampicin
rpoB 761948 c.2142G>C synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoB 761954 c.2148C>G synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoB 762284 c.2478G>C synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoB 762293 c.2487T>C synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoB 762317 c.2511A>G synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoB 762329 c.2523G>C synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoB 762338 c.2532T>C synonymous_variant 1.0 rifampicin
rpoB 762347 c.2541T>C synonymous_variant 1.0 rifampicin
rpoB 762362 p.Glu852Asp missense_variant 0.91 rifampicin
rpoC 762395 c.-975G>C upstream_gene_variant 0.75 rifampicin
rpoC 762398 c.-972T>C upstream_gene_variant 0.75 rifampicin
rpoC 762401 c.-969G>C upstream_gene_variant 0.75 rifampicin
rpoB 762404 c.2598T>C synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoC 762410 c.-960T>C upstream_gene_variant 0.67 rifampicin
rpoB 762416 c.2610A>G synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoC 762419 c.-951C>G upstream_gene_variant 0.67 rifampicin
rpoC 762434 c.-936T>C upstream_gene_variant 0.68 rifampicin
rpoB 762449 c.2643C>A synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoC 762467 c.-903C>T upstream_gene_variant 0.62 rifampicin
rpoB 762488 c.2682G>C synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoB 762489 p.Val895Gln missense_variant 0.62 rifampicin
rpoC 762509 c.-861T>G upstream_gene_variant 0.73 rifampicin
rpoB 762510 c.2704_2706delGCCinsCG frameshift_variant&missense_variant 0.73 rifampicin
rpoC 762521 c.-849C>T upstream_gene_variant 0.73 rifampicin
rpoB 762857 c.3051C>G synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoB 762860 c.3054G>C synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoB 762863 c.3057T>C synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoB 762929 c.3123G>C synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoC 762989 c.-381G>C upstream_gene_variant 0.6 rifampicin
rpoB 762995 c.3189G>T synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoC 763013 c.-357C>G upstream_gene_variant 0.6 rifampicin
rpoB 763040 c.3234C>G synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoB 763115 c.3309T>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 763190 c.-180C>T upstream_gene_variant 0.64 rifampicin
rpoC 763202 c.-168A>G upstream_gene_variant 0.5 rifampicin
rpoC 763205 c.-165G>C upstream_gene_variant 0.5 rifampicin
rpoC 763206 c.-164_-162delAGTinsTCG upstream_gene_variant 0.55 rifampicin
rpoB 763214 c.3408T>C synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoC 763226 c.-144A>G upstream_gene_variant 0.64 rifampicin
rpoB 763227 c.3421C>T synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoB 763238 c.3432T>C synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoC 763253 c.-117G>C upstream_gene_variant 0.43 rifampicin
rpoC 763256 c.-114G>A upstream_gene_variant 0.43 rifampicin
rpoC 763402 c.33C>G synonymous_variant 0.41 rifampicin
rpoC 763411 c.42T>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 763414 c.45T>C synonymous_variant 0.5 rifampicin
rpoC 763441 c.72C>T synonymous_variant 0.61 rifampicin
rpoC 763486 c.117T>G synonymous_variant 0.76 rifampicin
rpoC 763492 c.123G>C synonymous_variant 0.78 rifampicin Not assoc w R - Interim
rpoC 763528 c.159G>A synonymous_variant 0.81 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>C synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoC 763573 c.204G>C synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoC 763594 c.225C>T synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoC 763603 c.234C>T synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoC 763636 c.267T>C synonymous_variant 0.73 rifampicin
rpoC 763657 c.288G>A synonymous_variant 0.81 rifampicin Not assoc w R - Interim
rpoC 763660 c.291T>G synonymous_variant 0.81 rifampicin Not assoc w R - Interim
rpoC 763675 c.306C>G synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoC 763696 c.327T>C synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoC 763807 c.438T>C synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoC 763816 c.447C>G synonymous_variant 0.73 rifampicin
rpoC 763835 p.Ala156Met missense_variant 0.73 rifampicin
rpoC 763853 p.Val162Ile missense_variant 0.7 rifampicin
rpoC 764059 c.690G>T synonymous_variant 0.67 rifampicin
rpoC 764083 c.714A>G synonymous_variant 0.8 rifampicin
rpoC 764098 c.729A>G synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoC 764101 c.732C>G synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoC 764102 p.Val245Ile missense_variant 0.8 rifampicin
rpoC 764112 p.Tyr248Phe missense_variant 0.8 rifampicin
rpoC 764116 c.747C>T synonymous_variant 0.79 rifampicin Not assoc w R - Interim
rpoC 764131 c.762T>C synonymous_variant 0.63 rifampicin
rpoC 764188 c.819A>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 764195 p.Ser276Ile missense_variant 0.41 rifampicin
rpoC 764203 c.834G>C synonymous_variant 0.39 rifampicin
rpoC 764206 c.837T>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 764215 c.846A>G synonymous_variant 0.4 rifampicin
rpoC 764510 c.1141C>T synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoC 764752 c.1383G>C synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoC 764764 c.1395T>C synonymous_variant 0.79 rifampicin Not assoc w R - Interim
rpoC 764809 c.1440C>T synonymous_variant 0.76 rifampicin Not assoc w R
rpoC 764815 c.1446A>G synonymous_variant 0.79 rifampicin Not assoc w R - Interim
rpoC 764827 c.1458G>C synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoC 764858 c.1489T>C synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoC 764872 c.1503A>G synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoC 764911 c.1542A>G synonymous_variant 0.6 rifampicin
rpoC 764932 c.1563C>A synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoC 764948 c.1579T>C synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoC 764968 c.1599T>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 765383 p.Met672Leu missense_variant 0.83 rifampicin Uncertain significance
rpoC 765404 p.Leu679Val missense_variant 0.67 rifampicin
rpoC 765409 c.2040T>C synonymous_variant 0.67 rifampicin
rpoC 765421 c.2052C>G synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoC 765553 c.2184C>T synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoC 765556 c.2187G>C synonymous_variant 0.73 rifampicin
rpoC 765559 c.2190G>C synonymous_variant 0.73 rifampicin
rpoC 765580 c.2211G>C synonymous_variant 0.82 rifampicin
rpoC 765613 p.His748Gln missense_variant 0.8 rifampicin
rpoC 765625 c.2256C>G synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoC 765628 c.2259G>C synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoC 765631 p.Asp754Glu missense_variant 0.71 rifampicin
rpoC 765700 c.2331T>C synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoC 765734 c.2365T>C synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoC 765739 c.2370G>T synonymous_variant 0.67 rifampicin
rpoC 765751 c.2382C>G synonymous_variant 0.58 rifampicin
rpoC 765753 p.Asp795Ala missense_variant 0.58 rifampicin Uncertain significance
rpoC 765796 c.2427C>T synonymous_variant 0.5 rifampicin
rpoC 765811 c.2442T>C synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoC 765814 c.2445A>G synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoC 765826 c.2457T>C synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoC 765835 c.2466C>T synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoC 765850 c.2481G>C synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoC 765883 c.2514C>G synonymous_variant 0.64 rifampicin
rpoC 765886 c.2517C>G synonymous_variant 0.67 rifampicin
rpoC 765892 c.2523T>C synonymous_variant 0.79 rifampicin Not assoc w R - Interim
rpoC 765937 c.2568T>C synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoC 765947 c.2578T>C synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoC 765967 c.2598C>T synonymous_variant 0.79 rifampicin Not assoc w R - Interim
rpoC 765982 c.2613C>G synonymous_variant 0.71 rifampicin
rpoC 765994 c.2625A>T synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoC 766010 c.2641_2642delTCinsAG synonymous_variant 0.52 rifampicin
rpoC 766021 c.2652G>C synonymous_variant 0.5 rifampicin
rpoC 766027 c.2658G>C synonymous_variant 0.5 rifampicin
rpoC 766043 p.Gln892Glu missense_variant 0.47 rifampicin
rpoC 766054 c.2685C>G synonymous_variant 0.47 rifampicin
rpoC 766381 c.3012C>T synonymous_variant 0.58 rifampicin
rpoC 766384 c.3015A>G synonymous_variant 0.58 rifampicin
rpoC 766390 c.3021C>T synonymous_variant 0.64 rifampicin
rpoC 766393 c.3024C>G synonymous_variant 0.64 rifampicin
rpoC 766408 c.3039C>G synonymous_variant 0.64 rifampicin
rpoC 766411 c.3042C>G synonymous_variant 0.69 rifampicin
rpoC 766426 c.3057C>T synonymous_variant 0.9 rifampicin
rpoC 766447 c.3078T>C synonymous_variant 0.9 rifampicin
rpoC 766483 c.3114G>C synonymous_variant 0.9 rifampicin
rpoC 766484 c.3115_3117delGTAinsAC frameshift_variant&missense_variant 0.9 rifampicin
rpoC 766492 c.3123T>C synonymous_variant 0.91 rifampicin
rpoC 766522 c.3153C>G synonymous_variant 0.82 rifampicin
rpoC 766528 c.3159T>C synonymous_variant 0.82 rifampicin
rpoC 766531 c.3162G>C synonymous_variant 0.82 rifampicin
rpoC 766540 p.Asp1057Glu missense_variant 0.82 rifampicin
rpoC 766549 c.3180G>C synonymous_variant 0.92 rifampicin
rpoC 766861 c.3492G>C synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoC 766900 c.3531T>C synonymous_variant 0.82 rifampicin
rpoC 766972 c.3603G>C synonymous_variant 0.82 rifampicin
rpoC 766996 c.3627C>T synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoC 767009 c.3640_3642delTCGinsAGC synonymous_variant 0.73 rifampicin
rpoC 767014 c.3645G>C synonymous_variant 0.73 rifampicin
rpoC 767033 c.3664_3666delTCGinsAGC synonymous_variant 0.73 rifampicin
rpoC 767059 c.3690T>G synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoC 767062 c.3693C>A synonymous_variant 0.77 rifampicin
rpoC 767098 c.3729T>C synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoC 767119 c.3750A>G synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpsL 781808 c.249C>T synonymous_variant 0.69 streptomycin
rpsL 781811 c.252C>T synonymous_variant 0.69 streptomycin
rpsL 781832 c.273T>C synonymous_variant 0.67 streptomycin
rpsL 781838 c.279G>C synonymous_variant 0.69 streptomycin
rpsL 781841 c.282C>G synonymous_variant 0.69 streptomycin
rpsL 781865 c.306G>C synonymous_variant 0.71 streptomycin
rpsL 781868 c.309T>C synonymous_variant 0.77 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.83 streptomycin
rpsL 781877 c.318T>C synonymous_variant 0.85 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.92 streptomycin
rpsL 781916 c.357T>C synonymous_variant 0.82 streptomycin
rpsL 781929 p.Gly124Ser missense_variant 0.8 streptomycin Uncertain significance
rplC 800537 c.-272C>T upstream_gene_variant 0.47 linezolid
rplC 800540 c.-269T>C upstream_gene_variant 0.47 linezolid
rplC 800546 c.-263T>G upstream_gene_variant 0.47 linezolid
rplC 800567 c.-242A>G upstream_gene_variant 0.56 linezolid
rplC 800582 c.-227C>G upstream_gene_variant 0.67 linezolid
rplC 800612 c.-197A>G upstream_gene_variant 0.71 linezolid
rplC 800618 c.-191T>C upstream_gene_variant 0.8 linezolid
rplC 800627 c.-182C>T upstream_gene_variant 0.76 linezolid
rplC 800648 c.-161A>T upstream_gene_variant 0.76 linezolid
rplC 800654 c.-155T>C upstream_gene_variant 0.76 linezolid
rplC 800693 c.-116A>G upstream_gene_variant 0.53 linezolid
rplC 800703 c.-106T>C upstream_gene_variant 0.55 linezolid
rplC 800715 c.-94A>C upstream_gene_variant 0.5 linezolid
rplC 800720 c.-89T>C upstream_gene_variant 0.5 linezolid
rplC 800723 c.-86C>G upstream_gene_variant 0.42 linezolid
rplC 800747 c.-62C>G upstream_gene_variant 0.52 linezolid
rplC 800771 c.-38C>T upstream_gene_variant 0.5 linezolid
rplC 800794 c.-15A>G upstream_gene_variant 0.53 linezolid
rplC 800796 c.-13A>G upstream_gene_variant 0.44 linezolid
rplC 800798 c.-10_-9delGG upstream_gene_variant 0.44 linezolid
rplC 800814 c.6A>G synonymous_variant 0.61 linezolid
rplC 800817 c.9A>T synonymous_variant 0.64 linezolid
rplC 800844 c.36T>C synonymous_variant 0.5 linezolid
rplC 800865 c.57A>G synonymous_variant 0.6 linezolid
rplC 800867 p.Ser20Asn missense_variant 0.56 linezolid
rplC 800874 c.66A>G synonymous_variant 0.6 linezolid
rplC 800875 c.67_69delGTAinsAT frameshift_variant&missense_variant 0.6 linezolid
rplC 800880 c.72A>G synonymous_variant 0.6 linezolid
rplC 800889 c.81C>G synonymous_variant 0.64 linezolid
rplC 800892 c.84G>C synonymous_variant 0.64 linezolid
fbiC 1303836 c.906G>C synonymous_variant 0.67 clofazimine
pretomanid
delamanid
fbiC 1303845 c.915C>G synonymous_variant 0.67 clofazimine
pretomanid
delamanid
fbiC 1303846 p.Phe306Val missense_variant 0.67 clofazimine
pretomanid
delamanid
fbiC 1303854 c.924T>C synonymous_variant 0.62 clofazimine
pretomanid
delamanid
fbiC 1303860 c.930A>C synonymous_variant 0.62 clofazimine
pretomanid
delamanid
fbiC 1303914 c.984C>G synonymous_variant 0.7 clofazimine
pretomanid
delamanid
fbiC 1303920 c.990C>T synonymous_variant 0.6 clofazimine
pretomanid
delamanid
fbiC 1304559 p.Glu543Asp missense_variant 0.64 clofazimine
pretomanid
delamanid
fbiC 1304565 c.1635C>G synonymous_variant 0.64 clofazimine
pretomanid
delamanid
fbiC 1304568 c.1638T>C synonymous_variant 0.73 clofazimine
pretomanid
delamanid
fbiC 1304580 c.1650T>C synonymous_variant 0.8 clofazimine
pretomanid
delamanid
fbiC 1304778 c.1848T>C synonymous_variant 0.77 clofazimine
pretomanid
delamanid
fbiC 1304784 c.1854T>C synonymous_variant 0.77 clofazimine
pretomanid
delamanid
fbiC 1304787 c.1857T>G synonymous_variant 0.75 clofazimine
pretomanid
delamanid
fbiC 1304808 c.1878C>G synonymous_variant 0.73 clofazimine
pretomanid
delamanid
fbiC 1304811 c.1881C>G synonymous_variant 0.8 clofazimine
pretomanid
delamanid
fbiC 1304817 c.1887T>C synonymous_variant 0.73 clofazimine
pretomanid
delamanid
fbiC 1304829 c.1899T>C synonymous_variant 0.64 clofazimine
pretomanid
delamanid
fbiC 1304832 c.1902C>T synonymous_variant 0.67 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1304853 c.1923C>T synonymous_variant 0.7 clofazimine
pretomanid
delamanid
fbiC 1304856 c.1926C>G synonymous_variant 0.7 clofazimine
pretomanid
delamanid
fbiC 1304869 c.1939C>T synonymous_variant 0.7 clofazimine
pretomanid
delamanid
fbiC 1304907 c.1977C>G synonymous_variant 0.77 clofazimine
pretomanid
delamanid
fbiC 1304910 c.1980G>C synonymous_variant 0.77 clofazimine
pretomanid
delamanid
fbiC 1304916 c.1986T>C synonymous_variant 0.85 clofazimine
pretomanid
delamanid
fbiC 1304928 c.1998T>C synonymous_variant 0.93 clofazimine
pretomanid
delamanid
fbiC 1304937 c.2007G>C synonymous_variant 0.91 clofazimine
pretomanid
delamanid
fbiC 1304958 c.2028T>G synonymous_variant 0.92 clofazimine
pretomanid
delamanid
fbiC 1304983 c.2053C>T synonymous_variant 0.82 clofazimine
pretomanid
delamanid
fbiC 1304994 c.2064A>G synonymous_variant 0.75 clofazimine
pretomanid
delamanid
fbiC 1304995 p.Leu689Met missense_variant 0.75 clofazimine
pretomanid
delamanid
fbiC 1305006 c.2076A>G synonymous_variant 0.82 clofazimine
pretomanid
delamanid
fbiC 1305012 c.2082G>C synonymous_variant 0.8 clofazimine
pretomanid
delamanid
atpE 1460861 c.-184C>G upstream_gene_variant 0.55 bedaquiline
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.64 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472969 n.1124A>G non_coding_transcript_exon_variant 0.77 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472970 n.1125C>G non_coding_transcript_exon_variant 0.71 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472977 n.1132G>C non_coding_transcript_exon_variant 0.71 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472978 n.1133T>C non_coding_transcript_exon_variant 0.71 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473105 n.1260G>A non_coding_transcript_exon_variant 0.61 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473123 n.1278delAinsTT non_coding_transcript_exon_variant 0.44 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.41 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473290 n.1445C>T non_coding_transcript_exon_variant 0.8 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrl 1473756 n.99G>A non_coding_transcript_exon_variant 0.82 capreomycin
linezolid
rrl 1473758 n.101G>T non_coding_transcript_exon_variant 0.83 capreomycin Uncertain significance
linezolid
rrl 1473806 n.149C>T non_coding_transcript_exon_variant 0.82 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473877 n.220G>A non_coding_transcript_exon_variant 0.8 capreomycin
linezolid
rrl 1473898 n.241C>T non_coding_transcript_exon_variant 0.83 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473943 n.286G>T non_coding_transcript_exon_variant 0.86 capreomycin Uncertain significance
linezolid
rrl 1473945 n.288T>A non_coding_transcript_exon_variant 0.86 capreomycin Uncertain significance
linezolid
rrl 1473946 n.289A>T non_coding_transcript_exon_variant 0.86 capreomycin Uncertain significance
linezolid
rrl 1473986 n.329T>C non_coding_transcript_exon_variant 0.93 capreomycin
linezolid
rrl 1473987 n.330G>A non_coding_transcript_exon_variant 0.93 capreomycin
linezolid
rrl 1473995 n.338G>T non_coding_transcript_exon_variant 0.94 capreomycin
linezolid
rrl 1474001 n.344C>T non_coding_transcript_exon_variant 0.93 capreomycin Not assoc w R
linezolid Not assoc w R
rrl 1474009 n.352A>G non_coding_transcript_exon_variant 0.88 capreomycin
linezolid
rrl 1474012 n.355C>T non_coding_transcript_exon_variant 0.88 capreomycin
linezolid
rrl 1474093 n.436G>T non_coding_transcript_exon_variant 0.62 capreomycin
linezolid
rrl 1474099 n.442G>A non_coding_transcript_exon_variant 0.6 capreomycin
linezolid
rrl 1474103 n.446A>T non_coding_transcript_exon_variant 0.64 capreomycin
linezolid
rrl 1474140 n.483C>T non_coding_transcript_exon_variant 0.75 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.82 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474181 n.524C>T non_coding_transcript_exon_variant 0.85 capreomycin Uncertain significance
linezolid
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 0.87 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474356 n.699T>C non_coding_transcript_exon_variant 0.8 capreomycin Uncertain significance
linezolid
rrl 1474639 n.982G>A non_coding_transcript_exon_variant 0.73 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.72 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.78 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474823 n.1166C>T non_coding_transcript_exon_variant 0.71 capreomycin
linezolid
rrl 1474831 n.1174A>G non_coding_transcript_exon_variant 0.7 capreomycin Uncertain significance
linezolid
rrl 1474904 n.1247G>A non_coding_transcript_exon_variant 0.74 capreomycin
linezolid
rrl 1475006 n.1349A>T non_coding_transcript_exon_variant 0.83 capreomycin
linezolid
rrl 1475249 n.1592T>C non_coding_transcript_exon_variant 0.53 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475252 n.1595C>T non_coding_transcript_exon_variant 0.57 capreomycin
linezolid
rrl 1475313 n.1656G>A non_coding_transcript_exon_variant 0.64 capreomycin
linezolid
rrl 1475315 n.1658A>T non_coding_transcript_exon_variant 0.58 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475355 n.1698C>T non_coding_transcript_exon_variant 0.62 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475369 n.1712G>T non_coding_transcript_exon_variant 0.56 capreomycin
linezolid
rrl 1475402 n.1745C>T non_coding_transcript_exon_variant 0.65 capreomycin
linezolid
rrl 1475419 n.1762C>T non_coding_transcript_exon_variant 0.68 capreomycin Uncertain significance
linezolid
rrl 1475429 n.1772G>A non_coding_transcript_exon_variant 0.72 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475436 n.1779C>T non_coding_transcript_exon_variant 0.73 capreomycin
linezolid
rrl 1475483 n.1826C>T non_coding_transcript_exon_variant 0.91 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475505 n.1848G>A non_coding_transcript_exon_variant 0.89 capreomycin Uncertain significance
linezolid
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.86 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475599 n.1942A>G non_coding_transcript_exon_variant 0.53 capreomycin
linezolid Uncertain significance
rrl 1475608 n.1951T>C non_coding_transcript_exon_variant 0.53 capreomycin Uncertain significance
linezolid
rrl 1475657 n.2000A>G non_coding_transcript_exon_variant 0.62 capreomycin
linezolid
rrl 1475659 n.2002G>T non_coding_transcript_exon_variant 0.64 capreomycin
linezolid
rrl 1475761 n.2104_2106delCGCinsGT non_coding_transcript_exon_variant 0.71 capreomycin
linezolid
rrl 1475765 n.2111delG non_coding_transcript_exon_variant 0.75 capreomycin
linezolid
rrl 1475881 n.2224T>C non_coding_transcript_exon_variant 0.68 capreomycin
linezolid
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.5 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476086 n.2429G>A non_coding_transcript_exon_variant 0.65 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476089 n.2432T>C non_coding_transcript_exon_variant 0.62 capreomycin
linezolid
rrl 1476095 n.2438C>G non_coding_transcript_exon_variant 0.62 capreomycin
linezolid
rrl 1476115 n.2458T>C non_coding_transcript_exon_variant 0.53 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476117 n.2460G>C non_coding_transcript_exon_variant 0.58 capreomycin
linezolid
rrl 1476214 n.2557G>A non_coding_transcript_exon_variant 0.76 capreomycin
linezolid
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.73 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.86 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476583 n.2926G>A non_coding_transcript_exon_variant 0.61 capreomycin Uncertain significance
linezolid
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.61 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476594 n.2937C>T non_coding_transcript_exon_variant 0.67 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476597 n.2940G>A non_coding_transcript_exon_variant 0.67 capreomycin Uncertain significance
linezolid
rrl 1476603 n.2946G>A non_coding_transcript_exon_variant 0.63 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476608 n.2951C>G non_coding_transcript_exon_variant 0.68 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.84 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476689 n.3032A>T non_coding_transcript_exon_variant 0.9 capreomycin
linezolid
rrl 1476690 n.3033C>T non_coding_transcript_exon_variant 0.9 capreomycin Uncertain significance
linezolid
rrl 1476693 n.3036G>A non_coding_transcript_exon_variant 0.9 capreomycin
linezolid
rrl 1476695 n.3038T>A non_coding_transcript_exon_variant 0.9 capreomycin
linezolid
rrl 1476716 n.3059A>C non_coding_transcript_exon_variant 0.84 capreomycin Uncertain significance
linezolid
rrl 1476726 n.3069A>G non_coding_transcript_exon_variant 0.81 capreomycin
linezolid
rrl 1476732 n.3075T>C non_coding_transcript_exon_variant 0.8 capreomycin
linezolid
inhA 1673685 c.-517C>T upstream_gene_variant 0.8 ethionamide
isoniazid
fabG1 1673710 p.Leu91Ile missense_variant 0.82 ethionamide
isoniazid
inhA 1674546 c.345T>C synonymous_variant 0.7 ethionamide
isoniazid
inhA 1674549 c.348G>C synonymous_variant 0.7 ethionamide
isoniazid
inhA 1674552 c.351C>G synonymous_variant 0.7 ethionamide
isoniazid
inhA 1674555 c.354G>A synonymous_variant 0.7 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
inhA 1674582 c.381T>C synonymous_variant 0.69 ethionamide
isoniazid
inhA 1674585 c.384T>C synonymous_variant 0.67 ethionamide
isoniazid
inhA 1674589 p.Met130Leu missense_variant 0.67 ethionamide
isoniazid
inhA 1674601 p.Leu134Thr missense_variant 0.69 ethionamide
isoniazid
inhA 1674624 c.423A>C synonymous_variant 0.67 ethionamide
isoniazid
inhA 1674630 c.429C>G synonymous_variant 0.64 ethionamide
isoniazid
inhA 1674660 c.459G>C synonymous_variant 0.58 ethionamide
isoniazid
inhA 1674672 c.471C>G synonymous_variant 0.62 ethionamide
isoniazid
rpsA 1833568 c.27G>C synonymous_variant 0.64 pyrazinamide Not assoc w R - Interim
rpsA 1833589 c.48A>T synonymous_variant 0.65 pyrazinamide
rpsA 1833595 c.54T>C synonymous_variant 0.7 pyrazinamide
rpsA 1833661 c.120A>G synonymous_variant 0.67 pyrazinamide
rpsA 1833787 c.246C>G synonymous_variant 0.55 pyrazinamide
rpsA 1833790 c.249T>C synonymous_variant 0.58 pyrazinamide
rpsA 1833802 c.261A>G synonymous_variant 0.5 pyrazinamide
rpsA 1833940 c.399C>G synonymous_variant 0.7 pyrazinamide
rpsA 1833971 c.430C>T synonymous_variant 0.86 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.86 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.77 pyrazinamide
rpsA 1834021 c.480C>T synonymous_variant 0.83 pyrazinamide
rpsA 1834030 c.489C>G synonymous_variant 0.8 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.6 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 0.5 pyrazinamide Not assoc w R - Interim
rpsA 1834501 c.960G>C synonymous_variant 0.6 pyrazinamide
rpsA 1834510 c.969C>T synonymous_variant 0.69 pyrazinamide Not assoc w R - Interim
rpsA 1834513 c.972C>G synonymous_variant 0.73 pyrazinamide
rpsA 1834528 c.987T>C synonymous_variant 0.7 pyrazinamide
rpsA 1834609 c.1068T>C synonymous_variant 0.73 pyrazinamide
rpsA 1834618 c.1077G>C synonymous_variant 0.78 pyrazinamide
rpsA 1834633 c.1092A>G synonymous_variant 0.74 pyrazinamide
rpsA 1834639 c.1098T>C synonymous_variant 0.72 pyrazinamide
rpsA 1834654 p.Glu371Asp missense_variant 0.78 pyrazinamide
rpsA 1834684 c.1143C>T synonymous_variant 0.79 pyrazinamide
rpsA 1834690 c.1149T>C synonymous_variant 0.69 pyrazinamide
rpsA 1834765 p.Glu408Asp missense_variant 0.46 pyrazinamide
rpsA 1834775 p.Ala412Thr missense_variant 0.5 pyrazinamide
rpsA 1834780 c.1239A>G synonymous_variant 0.5 pyrazinamide
rpsA 1834786 c.1245A>G synonymous_variant 0.62 pyrazinamide
rpsA 1834789 c.1248T>C synonymous_variant 0.58 pyrazinamide
rpsA 1834792 c.1251G>C synonymous_variant 0.58 pyrazinamide
kasA 2518174 c.60A>G synonymous_variant 0.5 isoniazid
kasA 2518190 p.Ser26Ala missense_variant 0.6 isoniazid
kasA 2518199 p.Ile29Val missense_variant 0.6 isoniazid
kasA 2518672 c.558G>C synonymous_variant 0.54 isoniazid
kasA 2518684 c.570C>G synonymous_variant 0.54 isoniazid
kasA 2518696 c.582C>G synonymous_variant 0.62 isoniazid
kasA 2518768 c.654C>T synonymous_variant 0.82 isoniazid
kasA 2518777 c.663C>T synonymous_variant 0.8 isoniazid
kasA 2518783 c.669T>C synonymous_variant 0.82 isoniazid
kasA 2518789 c.675G>C synonymous_variant 0.8 isoniazid
kasA 2518792 c.678C>A synonymous_variant 0.8 isoniazid
kasA 2518795 c.681C>G synonymous_variant 0.83 isoniazid
kasA 2518825 c.711T>C synonymous_variant 0.83 isoniazid
kasA 2518864 c.750G>C synonymous_variant 0.69 isoniazid
kasA 2518879 c.765A>G synonymous_variant 0.75 isoniazid
kasA 2518885 c.771T>C synonymous_variant 0.75 isoniazid
kasA 2518898 c.784T>C synonymous_variant 0.7 isoniazid
folC 2747275 c.324T>C synonymous_variant 0.5 para-aminosalicylic_acid
folC 2747289 p.Pro104Ala missense_variant 0.5 para-aminosalicylic_acid
folC 2747290 c.309A>G synonymous_variant 0.5 para-aminosalicylic_acid
folC 2747293 c.306G>A synonymous_variant 0.5 para-aminosalicylic_acid
folC 2747302 c.297A>C synonymous_variant 0.57 para-aminosalicylic_acid
folC 2747314 c.285A>C synonymous_variant 0.57 para-aminosalicylic_acid
folC 2747317 c.282C>G synonymous_variant 0.67 para-aminosalicylic_acid
folC 2747343 p.Val86Ile missense_variant 0.73 para-aminosalicylic_acid
folC 2747355 p.Val82Ile missense_variant 0.7 para-aminosalicylic_acid
folC 2747359 c.240C>G synonymous_variant 0.64 para-aminosalicylic_acid
folC 2747362 c.237G>C synonymous_variant 0.64 para-aminosalicylic_acid
Rv2477c 2782912 p.Ser377Thr missense_variant 0.55 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782927 p.Thr372Glu missense_variant 0.58 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782936 c.1107G>T synonymous_variant 0.57 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782957 c.1086A>G synonymous_variant 0.71 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2782966 c.1077C>A synonymous_variant 0.73 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782969 c.1074A>C synonymous_variant 0.71 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782972 c.1071G>C synonymous_variant 0.69 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782981 c.1062G>C synonymous_variant 0.67 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782984 c.1059T>C synonymous_variant 0.67 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783182 c.861C>G synonymous_variant 0.6 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783185 c.858G>A synonymous_variant 0.6 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783194 c.849A>G synonymous_variant 0.55 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783221 c.822G>C synonymous_variant 0.7 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783224 c.819C>G synonymous_variant 0.7 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783230 c.813T>G synonymous_variant 0.64 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783235 c.808T>C synonymous_variant 0.55 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783254 c.789A>G synonymous_variant 0.54 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783674 c.369T>C synonymous_variant 0.7 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783683 c.360A>G synonymous_variant 0.7 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783700 p.Thr115Ser missense_variant 0.75 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783718 c.325T>C synonymous_variant 0.67 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783719 c.324A>G synonymous_variant 0.67 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783751 p.Ile98Val missense_variant 0.7 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2784452 c.-410C>T upstream_gene_variant 0.54 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2784454 c.-412G>A upstream_gene_variant 0.58 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2784456 c.-414A>C upstream_gene_variant 0.58 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2752c 3066501 c.-310G>C upstream_gene_variant 0.5 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066522 c.-331C>G upstream_gene_variant 0.6 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066531 c.-340C>G upstream_gene_variant 0.6 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
thyX 3067601 p.Arg115His missense_variant 0.8 para-aminosalicylic_acid
thyX 3067611 p.Lys112Thr missense_variant 0.73 para-aminosalicylic_acid
thyX 3067619 c.327A>C synonymous_variant 0.7 para-aminosalicylic_acid
thyX 3067631 c.315C>G synonymous_variant 0.64 para-aminosalicylic_acid
thyX 3067634 c.312C>G synonymous_variant 0.64 para-aminosalicylic_acid
thyX 3067661 c.285C>G synonymous_variant 0.62 para-aminosalicylic_acid
thyX 3067761 p.Arg62Lys missense_variant 0.73 para-aminosalicylic_acid
thyX 3067765 p.Leu61Ile missense_variant 0.73 para-aminosalicylic_acid
thyX 3067772 c.174C>G synonymous_variant 0.9 para-aminosalicylic_acid
thyX 3067775 c.171C>T synonymous_variant 0.9 para-aminosalicylic_acid
thyX 3067781 c.165C>G synonymous_variant 0.9 para-aminosalicylic_acid
thyX 3067793 c.153T>C synonymous_variant 0.9 para-aminosalicylic_acid
thyX 3067799 c.147G>A synonymous_variant 0.91 para-aminosalicylic_acid
thyX 3067802 c.144C>G synonymous_variant 0.92 para-aminosalicylic_acid
thyX 3067814 c.132T>C synonymous_variant 0.85 para-aminosalicylic_acid
lpqB 3624722 c.189C>G synonymous_variant 0.6 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
lpqB 3624728 c.183C>T synonymous_variant 0.6 bedaquiline
rifampicin
lpqB 3624749 c.162G>A synonymous_variant 0.67 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3624755 c.154_156delTTAinsCG frameshift_variant&missense_variant 0.67 bedaquiline
rifampicin Uncertain significance
mtrB 3625065 p.Met517Leu missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
lpqB 3625537 c.-627T>C upstream_gene_variant 0.6 bedaquiline
rifampicin
lpqB 3625543 c.-633G>C upstream_gene_variant 0.7 bedaquiline
rifampicin
mtrB 3625569 c.1045T>C synonymous_variant 0.6 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625572 p.Thr348Ser missense_variant 0.6 bedaquiline
rifampicin
lpqB 3625579 c.-669A>G upstream_gene_variant 0.65 bedaquiline
rifampicin
lpqB 3625594 c.-684T>C upstream_gene_variant 0.64 bedaquiline
rifampicin
lpqB 3625602 c.-692T>C upstream_gene_variant 0.67 bedaquiline
rifampicin
lpqB 3625612 c.-702G>C upstream_gene_variant 0.62 bedaquiline
rifampicin
mtrB 3625616 p.Arg333Ala missense_variant 0.57 bedaquiline
rifampicin
lpqB 3625624 c.-714C>G upstream_gene_variant 0.5 bedaquiline
rifampicin
mtrB 3625636 c.978C>G synonymous_variant 0.44 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625656 c.958T>C synonymous_variant 0.35 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
mtrB 3625837 c.777C>G synonymous_variant 0.53 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625843 c.-933C>G upstream_gene_variant 0.62 bedaquiline
rifampicin
lpqB 3625849 c.-939T>C upstream_gene_variant 0.64 bedaquiline
rifampicin
mtrB 3625852 c.762A>G synonymous_variant 0.62 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625864 c.-954T>G upstream_gene_variant 0.58 bedaquiline
rifampicin
mtrA 3626723 c.627C>T synonymous_variant 0.5 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626726 c.-113T>C upstream_gene_variant 0.5 bedaquiline
rifampicin
mtrB 3626729 c.-116G>A upstream_gene_variant 0.5 bedaquiline
rifampicin
mtrB 3626732 c.-119A>G upstream_gene_variant 0.5 bedaquiline
rifampicin
mtrB 3626972 c.-359A>G upstream_gene_variant 0.35 bedaquiline
rifampicin
mtrB 3627008 c.-395G>C upstream_gene_variant 0.6 bedaquiline
rifampicin
mtrB 3627011 c.-398T>G upstream_gene_variant 0.62 bedaquiline
rifampicin
mtrA 3627056 c.294C>T synonymous_variant 0.44 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627065 c.-452G>C upstream_gene_variant 0.44 bedaquiline
rifampicin
mtrA 3627068 c.282T>C synonymous_variant 0.44 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3627071 c.279G>T synonymous_variant 0.44 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627074 c.-461G>C upstream_gene_variant 0.47 bedaquiline
rifampicin
mtrA 3627080 c.270T>C synonymous_variant 0.5 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627083 c.-470G>C upstream_gene_variant 0.47 bedaquiline
rifampicin
mtrA 3627098 c.252A>C synonymous_variant 0.44 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627104 c.-491C>G upstream_gene_variant 0.41 bedaquiline
rifampicin
mtrA 3627146 c.204C>T synonymous_variant 0.35 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627209 c.-596G>A upstream_gene_variant 0.44 bedaquiline
rifampicin
mtrA 3627221 c.129C>T synonymous_variant 0.53 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3627227 c.123T>C synonymous_variant 0.53 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627233 c.-620T>C upstream_gene_variant 0.53 bedaquiline
rifampicin
mtrB 3627236 c.-623T>C upstream_gene_variant 0.53 bedaquiline
rifampicin
rpoA 3877553 p.Glu319Gln missense_variant 0.75 rifampicin
rpoA 3877571 p.Pro313Ala missense_variant 0.93 rifampicin
rpoA 3877587 c.921A>G synonymous_variant 0.93 rifampicin Not assoc w R - Interim
rpoA 3877613 p.Ile299Val missense_variant 1.0 rifampicin
rpoA 3877656 c.852T>G synonymous_variant 0.93 rifampicin Not assoc w R - Interim
rpoA 3877668 c.840A>G synonymous_variant 0.92 rifampicin
rpoA 3877679 p.Ala277Ser missense_variant 0.86 rifampicin
rpoA 3877686 c.822A>G synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoA 3877692 c.816G>C synonymous_variant 0.84 rifampicin Not assoc w R - Interim
rpoA 3877704 c.804G>C synonymous_variant 0.85 rifampicin
rpoA 3877737 c.771G>C synonymous_variant 0.86 rifampicin
rpoA 3877743 c.765T>C synonymous_variant 0.85 rifampicin Not assoc w R - Interim
rpoA 3877764 c.744C>G synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoA 3877770 c.738A>G synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoA 3877776 c.732T>C synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoA 3877782 c.726T>C synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoA 3877791 c.717C>G synonymous_variant 0.93 rifampicin
rpoA 3877818 c.690A>G synonymous_variant 0.85 rifampicin Not assoc w R - Interim
rpoA 3877839 c.669G>C synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoA 3877848 c.660C>T synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoA 3877857 c.651G>A synonymous_variant 0.82 rifampicin
rpoA 3878022 c.486T>C synonymous_variant 0.7 rifampicin
rpoA 3878346 c.162T>C synonymous_variant 0.69 rifampicin
rpoA 3878364 c.144A>C synonymous_variant 0.64 rifampicin
rpoA 3878367 c.141C>G synonymous_variant 0.64 rifampicin
rpoA 3878376 c.132G>C synonymous_variant 0.64 rifampicin
rpoA 3878385 c.123C>G synonymous_variant 0.58 rifampicin
rpoA 3878388 c.120C>G synonymous_variant 0.58 rifampicin
rpoA 3878391 c.117T>C synonymous_variant 0.5 rifampicin
rpoA 3878415 c.93C>T synonymous_variant 0.58 rifampicin
rpoA 3878424 c.84G>C synonymous_variant 0.65 rifampicin
rpoA 3878436 c.72A>G synonymous_variant 0.64 rifampicin
rpoA 3878853 c.-346G>A upstream_gene_variant 0.57 rifampicin
rpoA 3878860 c.-353C>T upstream_gene_variant 0.54 rifampicin
rpoA 3878878 c.-371T>C upstream_gene_variant 0.71 rifampicin Uncertain significance
rpoA 3878909 c.-402A>G upstream_gene_variant 0.67 rifampicin
rpoA 3878914 c.-407T>C upstream_gene_variant 0.67 rifampicin Uncertain significance
rpoA 3878917 c.-410G>A upstream_gene_variant 0.64 rifampicin Uncertain significance
rpoA 3878938 c.-431T>A upstream_gene_variant 0.64 rifampicin
rpoA 3878962 c.-455G>A upstream_gene_variant 0.6 rifampicin Uncertain significance
rpoA 3878968 c.-461T>C upstream_gene_variant 0.57 rifampicin Uncertain significance
rpoA 3878976 c.-469A>G upstream_gene_variant 0.58 rifampicin Uncertain significance
rpoA 3878986 c.-479G>C upstream_gene_variant 0.5 rifampicin
rpoA 3879079 c.-572A>G upstream_gene_variant 0.65 rifampicin
rpoA 3879088 c.-581A>C upstream_gene_variant 0.72 rifampicin
rpoA 3879094 c.-587T>C upstream_gene_variant 0.72 rifampicin
rpoA 3879121 c.-614T>G upstream_gene_variant 0.74 rifampicin
rpoA 3879127 c.-620T>C upstream_gene_variant 0.72 rifampicin
rpoA 3879154 c.-647T>C upstream_gene_variant 0.61 rifampicin
rpoA 3879160 c.-653A>G upstream_gene_variant 0.61 rifampicin
rpoA 3879178 c.-671T>C upstream_gene_variant 0.67 rifampicin
rpoA 3879190 c.-683C>G upstream_gene_variant 0.7 rifampicin
clpC1 4038530 c.2175G>A synonymous_variant 0.59 pyrazinamide
clpC1 4038596 c.2109A>G synonymous_variant 0.92 pyrazinamide
clpC1 4038623 c.2082A>G synonymous_variant 0.73 pyrazinamide
clpC1 4038749 c.1956C>G synonymous_variant 0.7 pyrazinamide
clpC1 4038755 c.1950G>T synonymous_variant 0.67 pyrazinamide
clpC1 4038770 c.1935C>T synonymous_variant 0.58 pyrazinamide
clpC1 4038773 c.1932T>C synonymous_variant 0.58 pyrazinamide
clpC1 4038782 c.1923G>C synonymous_variant 0.5 pyrazinamide
clpC1 4038956 c.1749T>C synonymous_variant 0.53 pyrazinamide
clpC1 4038965 c.1740T>C synonymous_variant 0.56 pyrazinamide
clpC1 4038971 c.1734T>C synonymous_variant 0.59 pyrazinamide
clpC1 4038974 c.1731T>C synonymous_variant 0.62 pyrazinamide Not assoc w R - Interim
clpC1 4038989 c.1716T>C synonymous_variant 0.85 pyrazinamide
clpC1 4038997 c.1708T>C synonymous_variant 0.85 pyrazinamide Not assoc w R - Interim
clpC1 4039004 c.1701C>G synonymous_variant 0.79 pyrazinamide
clpC1 4039103 c.1602T>C synonymous_variant 0.67 pyrazinamide
clpC1 4039106 c.1599G>C synonymous_variant 0.67 pyrazinamide
clpC1 4039112 c.1593C>G synonymous_variant 0.7 pyrazinamide
clpC1 4039121 c.1584T>C synonymous_variant 0.82 pyrazinamide
clpC1 4039169 p.Glu512Asp missense_variant 0.73 pyrazinamide
clpC1 4039172 c.1533A>G synonymous_variant 0.73 pyrazinamide
clpC1 4039178 c.1527G>C synonymous_variant 0.73 pyrazinamide
clpC1 4039183 c.1522T>C synonymous_variant 0.79 pyrazinamide
clpC1 4039186 c.1519C>T synonymous_variant 0.79 pyrazinamide
clpC1 4039226 c.1479T>C synonymous_variant 0.71 pyrazinamide Not assoc w R - Interim
clpC1 4039274 c.1431G>C synonymous_variant 0.67 pyrazinamide Not assoc w R - Interim
clpC1 4039280 c.1425G>T synonymous_variant 0.6 pyrazinamide Not assoc w R - Interim
clpC1 4039286 c.1419T>C synonymous_variant 0.55 pyrazinamide
clpC1 4039442 c.1263A>G synonymous_variant 0.64 pyrazinamide
clpC1 4039469 c.1236T>C synonymous_variant 0.6 pyrazinamide
clpC1 4039937 c.768G>C synonymous_variant 0.53 pyrazinamide
clpC1 4039946 c.759A>C synonymous_variant 0.56 pyrazinamide
clpC1 4039952 c.753T>C synonymous_variant 0.56 pyrazinamide
clpC1 4040450 c.255A>G synonymous_variant 0.43 pyrazinamide Not assoc w R - Interim
clpC1 4040459 c.246C>G synonymous_variant 0.47 pyrazinamide
clpC1 4040465 c.240T>C synonymous_variant 0.47 pyrazinamide
clpC1 4040471 c.234T>C synonymous_variant 0.5 pyrazinamide Not assoc w R - Interim
clpC1 4040477 c.228G>C synonymous_variant 0.5 pyrazinamide
clpC1 4040480 c.225T>G synonymous_variant 0.5 pyrazinamide
clpC1 4040522 c.183T>C synonymous_variant 0.64 pyrazinamide Not assoc w R - Interim
glpK 4138718 c.1038T>C synonymous_variant 0.76 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138721 c.1035G>A synonymous_variant 0.76 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4138724 c.1032A>G synonymous_variant 0.78 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138730 c.1026C>G synonymous_variant 0.76 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138757 c.999A>G synonymous_variant 0.65 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138763 c.993G>A synonymous_variant 0.65 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138769 c.987G>C synonymous_variant 0.59 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138774 p.Ser328Ala missense_variant 0.56 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138778 c.978C>G synonymous_variant 0.53 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
embC 4240819 c.957A>G synonymous_variant 0.8 ethambutol
embC 4240828 c.966G>A synonymous_variant 0.83 ethambutol
embC 4240831 c.969T>G synonymous_variant 0.75 ethambutol
embC 4241107 c.1245G>C synonymous_variant 0.83 ethambutol
embC 4241140 c.1278A>G synonymous_variant 0.85 ethambutol Not assoc w R - Interim
embC 4241146 c.1284C>G synonymous_variant 0.92 ethambutol
embC 4241158 c.1296T>C synonymous_variant 0.83 ethambutol
embC 4241161 c.1299C>G synonymous_variant 0.82 ethambutol Not assoc w R - Interim
embC 4241162 c.1300T>C synonymous_variant 0.82 ethambutol
embC 4241170 c.1308G>C synonymous_variant 0.82 ethambutol
embC 4241173 c.1311C>T synonymous_variant 0.75 ethambutol
embC 4241179 c.1317G>A synonymous_variant 0.75 ethambutol
embC 4241203 c.1341T>C synonymous_variant 0.73 ethambutol
embA 4245182 c.1950T>C synonymous_variant 0.7 ethambutol
embA 4245189 c.1957C>T synonymous_variant 0.73 ethambutol
embA 4245198 p.Leu656Ile missense_variant 0.73 ethambutol
embA 4245207 c.1975T>C synonymous_variant 0.7 ethambutol
embA 4245215 c.1983A>C synonymous_variant 0.7 ethambutol
embA 4245222 c.1990_1992delTATinsCG frameshift_variant&missense_variant 0.75 ethambutol Uncertain significance
embA 4245248 c.2016G>C synonymous_variant 0.73 ethambutol
embB 4247512 c.999T>C synonymous_variant 0.58 ethambutol
embB 4247539 c.1026T>C synonymous_variant 0.55 ethambutol
embB 4247797 c.1284C>G synonymous_variant 0.62 ethambutol
embB 4247800 c.1287A>T synonymous_variant 0.62 ethambutol
embB 4247803 c.1290G>C synonymous_variant 0.62 ethambutol
embB 4247815 c.1302C>G synonymous_variant 0.62 ethambutol
embB 4247819 c.1306_1308delGTTinsAC frameshift_variant&missense_variant 0.67 ethambutol
embB 4247830 c.1317A>G synonymous_variant 0.69 ethambutol Not assoc w R - Interim
embB 4247836 c.1323A>G synonymous_variant 0.71 ethambutol Not assoc w R - Interim
embB 4247839 c.1326G>C synonymous_variant 0.71 ethambutol Not assoc w R - Interim
embB 4248142 c.1629T>C synonymous_variant 0.7 ethambutol
embB 4248220 c.1707A>C synonymous_variant 0.63 ethambutol
embB 4248304 c.1791G>C synonymous_variant 0.87 ethambutol
embB 4248373 c.1860C>G synonymous_variant 0.73 ethambutol