TB-Profiler result

Run: SRR22424765
Summary

Run ID: SRR22424765

Sample name:

Date: 04-04-2023 04:10:49

Number of reads: 448258

Percentage reads mapped: 28.73

Strain: lineage4

Drug-resistance: MDR-TB

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
rpoB 761155 p.Ser450Leu missense_variant 0.5 rifampicin
rpoB 761161 p.Leu452Pro missense_variant 0.5 rifampicin
fabG1 1673425 c.-15C>T upstream_gene_variant 1.0 isoniazid, ethionamide
pncA 2288945 p.Tyr99* stop_gained 0.17 pyrazinamide
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 8437 c.1138dupC frameshift_variant 0.22
mshA 576570 p.Leu408Trp missense_variant 0.4
rpoB 760378 c.573delG frameshift_variant 0.2
rpoB 761015 c.1209G>C synonymous_variant 0.29
rpoB 761027 c.1221A>G synonymous_variant 0.25
rpoB 761036 c.1230G>C synonymous_variant 0.22
rpoB 761037 c.1231T>C synonymous_variant 0.22
rpoB 761057 c.1251G>C synonymous_variant 0.3
rpoB 761064 p.Ala420Ser missense_variant 0.3
rpoB 761097 c.1291_1292delAGinsTC synonymous_variant 0.31
rpoB 761102 c.1296A>G synonymous_variant 0.31
rpoB 761312 c.1506G>A synonymous_variant 1.0
rpoB 762003 p.Asn733His missense_variant 0.4
rpoB 762101 c.2295C>G synonymous_variant 0.4
rpoB 762114 p.Ile770Val missense_variant 0.4
rpoB 762122 p.Asp772Glu missense_variant 0.25
rpoB 762128 c.2322G>C synonymous_variant 0.4
rpoB 762140 c.2334G>C synonymous_variant 0.27
rpoB 762143 c.2337T>C synonymous_variant 0.27
rpoB 762149 c.2343G>C synonymous_variant 0.31
rpoB 762156 p.Val784Ile missense_variant 0.31
rpoB 762175 c.2369_2370insCG frameshift_variant 0.31
rpoB 762179 c.2374_2375delGA frameshift_variant 0.31
rpoB 762185 c.2379G>C synonymous_variant 0.31
rpoB 762194 c.2388G>C synonymous_variant 0.31
rpoB 762209 c.2403C>G synonymous_variant 0.27
rpoB 762212 c.2406G>C synonymous_variant 0.25
rpoB 762233 c.2427G>C synonymous_variant 0.25
rpoB 762245 c.2439G>C synonymous_variant 0.2
rpoB 762251 c.2445G>C synonymous_variant 0.2
rpoB 762254 c.2448T>C synonymous_variant 0.2
rpoB 762257 c.2451C>G synonymous_variant 0.2
rpoC 762899 c.-471G>C upstream_gene_variant 0.43
rpoB 762909 p.Ile1035Leu missense_variant 0.43
rpoC 762920 c.-450C>G upstream_gene_variant 0.43
rpoC 762923 c.-447C>G upstream_gene_variant 0.43
rpoC 762929 c.-441G>C upstream_gene_variant 0.43
rpoC 762962 c.-408C>T upstream_gene_variant 0.71
rpoC 762971 c.-399G>C upstream_gene_variant 0.62
rpoC 762989 c.-381G>C upstream_gene_variant 0.62
rpoC 762995 c.-375G>T upstream_gene_variant 0.56
rpoB 763005 p.Cys1067Val missense_variant 0.56
rpoC 763013 c.-357C>G upstream_gene_variant 0.62
rpoB 763014 p.Met1070Leu missense_variant 0.62
rpoB 763017 p.Gln1071Glu missense_variant 0.62
rpoC 763022 c.-348C>T upstream_gene_variant 0.62
rpoC 763028 c.-342T>C upstream_gene_variant 0.71
rpoC 763031 c.-339T>C upstream_gene_variant 0.71
rpoC 763034 c.-336C>G upstream_gene_variant 0.71
rpoB 763038 p.Thr1078Ala missense_variant 0.71
rpoC 763043 c.-327G>C upstream_gene_variant 0.71
rpoC 763053 c.-317T>C upstream_gene_variant 0.75
rpoC 763070 c.-300T>C upstream_gene_variant 0.75
rpoB 763074 p.Thr1090Val missense_variant 0.75
rpoB 763077 p.Val1091Thr missense_variant 0.75
rpoC 763088 c.-282C>G upstream_gene_variant 0.75
rpoC 763094 c.-276G>C upstream_gene_variant 0.6
rpoC 763103 c.-267G>C upstream_gene_variant 0.5
rpoC 763115 c.-255T>C upstream_gene_variant 0.22
rpoC 763127 c.-243G>T upstream_gene_variant 0.29
rpoC 763133 c.-237G>C upstream_gene_variant 0.29
rpoC 763148 c.-222G>C upstream_gene_variant 0.29
rpoC 763393 c.24T>C synonymous_variant 0.33
rpoC 763396 c.27A>G synonymous_variant 0.33
rpoC 763402 c.33C>G synonymous_variant 0.31
rpoC 763411 c.42T>G synonymous_variant 0.27
rpoC 763414 c.45T>C synonymous_variant 0.27
rpoC 763420 c.51G>T synonymous_variant 0.27
rpoC 763423 p.Glu18Asp missense_variant 0.27
rpoC 763427 p.Ile20Phe missense_variant 0.13
rpoC 763430 c.61_63delAGGinsCGT synonymous_variant 0.27
rpoC 763435 c.66A>G synonymous_variant 0.25
rpoC 763439 c.70_71delTCinsAG synonymous_variant 0.24
rpoC 763442 p.Tyr25His missense_variant 0.24
rpoC 763456 c.87A>G synonymous_variant 0.28
rpoC 763462 c.93G>C synonymous_variant 0.35
rpoC 763468 c.99G>C synonymous_variant 0.35
rpoC 763483 c.114G>C synonymous_variant 0.33
rpoC 763486 c.117T>C synonymous_variant 0.33
rpoC 763492 c.123G>C synonymous_variant 0.32
rpoC 763495 c.126G>A synonymous_variant 0.32
rpoC 763504 c.135C>A synonymous_variant 0.4
rpoC 763507 c.138G>C synonymous_variant 0.4
rpoC 763528 c.159G>T synonymous_variant 0.42
rpoC 763534 c.165T>C synonymous_variant 0.42
rpoC 763537 c.168C>G synonymous_variant 0.44
rpoC 763546 c.177A>G synonymous_variant 0.48
rpoC 763570 c.201G>C synonymous_variant 0.48
rpoC 763573 c.204G>C synonymous_variant 0.46
rpoC 763594 c.225C>T synonymous_variant 0.46
rpoC 763603 c.234C>T synonymous_variant 0.48
rpoC 763615 c.246G>C synonymous_variant 0.5
rpoC 763618 c.249C>G synonymous_variant 0.52
rpoC 763633 c.264T>C synonymous_variant 0.42
rpoC 763660 c.291T>G synonymous_variant 0.4
rpoC 763666 c.297G>T synonymous_variant 0.4
rpoC 763696 c.327T>C synonymous_variant 0.42
rpoC 763699 c.330G>T synonymous_variant 0.42
rpoC 763702 c.333C>G synonymous_variant 0.36
rpoC 763714 c.345G>C synonymous_variant 0.3
rpoC 763717 c.348T>C synonymous_variant 0.3
rpoC 763723 c.354G>C synonymous_variant 0.3
rpoC 763729 c.360G>C synonymous_variant 0.3
rpoC 763744 c.375G>C synonymous_variant 0.25
rpoC 764359 c.990C>G synonymous_variant 0.38
rpoC 764365 c.996C>T synonymous_variant 0.38
rpoC 764371 c.1002G>C synonymous_variant 0.38
rpoC 764377 c.1008C>G synonymous_variant 0.38
rpoC 764380 c.1011G>C synonymous_variant 0.38
rpoC 764387 c.1018T>C synonymous_variant 0.38
rpoC 764405 c.1036_1038delAGGinsCGT synonymous_variant 0.29
rpoC 764428 c.1059G>C synonymous_variant 0.33
rpoC 764705 p.Leu446Ala missense_variant 0.17
mmpL5 775639 p.Ile948Val missense_variant 1.0
mmpL5 777766 p.Gly239Trp missense_variant 0.33
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrs 1471819 n.-27C>T upstream_gene_variant 0.4
rrs 1472094 n.249T>A non_coding_transcript_exon_variant 0.38
rrs 1472102 n.257G>A non_coding_transcript_exon_variant 1.0
rrs 1472106 n.261G>A non_coding_transcript_exon_variant 1.0
rrs 1472112 n.267C>T non_coding_transcript_exon_variant 1.0
rrs 1472113 n.268T>C non_coding_transcript_exon_variant 1.0
rrs 1472148 n.303T>C non_coding_transcript_exon_variant 1.0
rrs 1472150 n.305T>A non_coding_transcript_exon_variant 1.0
rrs 1472172 n.327T>C non_coding_transcript_exon_variant 0.96
rrs 1472225 n.380C>A non_coding_transcript_exon_variant 1.0
rrs 1472251 n.406G>A non_coding_transcript_exon_variant 1.0
rrs 1472286 n.441C>G non_coding_transcript_exon_variant 1.0
rrs 1472289 n.444T>G non_coding_transcript_exon_variant 1.0
rrs 1472290 n.445C>G non_coding_transcript_exon_variant 1.0
rrs 1472293 n.448C>A non_coding_transcript_exon_variant 0.95
rrs 1472297 n.453_465delGTCCGGGTTCTCT non_coding_transcript_exon_variant 1.0
rrs 1472315 n.470T>G non_coding_transcript_exon_variant 1.0
rrs 1472324 n.479G>C non_coding_transcript_exon_variant 1.0
rrs 1472325 n.480G>C non_coding_transcript_exon_variant 1.0
rrs 1472328 n.483G>C non_coding_transcript_exon_variant 1.0
rrs 1472338 n.493A>G non_coding_transcript_exon_variant 1.0
rrs 1472344 n.499C>T non_coding_transcript_exon_variant 1.0
rrs 1472379 n.534T>C non_coding_transcript_exon_variant 1.0
rrs 1472382 n.537G>A non_coding_transcript_exon_variant 1.0
rrs 1472400 n.555C>T non_coding_transcript_exon_variant 1.0
rrs 1472422 n.577T>C non_coding_transcript_exon_variant 1.0
rrs 1472425 n.580T>C non_coding_transcript_exon_variant 1.0
rrs 1472431 n.586G>A non_coding_transcript_exon_variant 1.0
rrs 1472435 n.590T>C non_coding_transcript_exon_variant 1.0
rrs 1472437 n.592T>G non_coding_transcript_exon_variant 1.0
rrs 1472439 n.594C>T non_coding_transcript_exon_variant 1.0
rrs 1472446 n.601T>G non_coding_transcript_exon_variant 1.0
rrs 1472448 n.603T>C non_coding_transcript_exon_variant 1.0
rrs 1472450 n.605A>G non_coding_transcript_exon_variant 1.0
rrs 1472451 n.606C>G non_coding_transcript_exon_variant 1.0
rrs 1472460 n.615T>C non_coding_transcript_exon_variant 0.9
rrs 1472461 n.616G>C non_coding_transcript_exon_variant 0.9
rrs 1472462 n.617T>C non_coding_transcript_exon_variant 0.89
rrs 1472464 n.619A>G non_coding_transcript_exon_variant 0.9
rrs 1472466 n.621C>T non_coding_transcript_exon_variant 0.9
rrs 1472467 n.622G>C non_coding_transcript_exon_variant 0.9
rrs 1472471 n.626G>A non_coding_transcript_exon_variant 0.9
rrs 1472473 n.628G>T non_coding_transcript_exon_variant 0.9
rrs 1472486 n.641A>G non_coding_transcript_exon_variant 0.92
rrs 1472494 n.649A>T non_coding_transcript_exon_variant 0.92
rrs 1472496 n.651T>G non_coding_transcript_exon_variant 0.92
rrs 1472498 n.653C>T non_coding_transcript_exon_variant 0.92
rrs 1472507 n.662C>T non_coding_transcript_exon_variant 0.92
rrs 1472508 n.663T>C non_coding_transcript_exon_variant 0.92
rrs 1472530 n.685G>A non_coding_transcript_exon_variant 0.93
rrs 1472571 n.726G>A non_coding_transcript_exon_variant 0.95
rrs 1472581 n.736A>C non_coding_transcript_exon_variant 0.95
rrs 1472583 n.738T>A non_coding_transcript_exon_variant 0.95
rrs 1472584 n.739A>T non_coding_transcript_exon_variant 0.95
rrs 1472660 n.815T>C non_coding_transcript_exon_variant 0.9
rrs 1472673 n.828T>C non_coding_transcript_exon_variant 0.89
rrs 1472674 n.829T>A non_coding_transcript_exon_variant 0.89
rrs 1472675 n.830T>A non_coding_transcript_exon_variant 0.89
rrs 1472677 n.832C>A non_coding_transcript_exon_variant 0.89
rrs 1472697 n.852T>C non_coding_transcript_exon_variant 0.91
rrs 1472714 n.869A>G non_coding_transcript_exon_variant 0.92
rrs 1472793 n.948A>C non_coding_transcript_exon_variant 0.78
rrs 1472803 n.958T>C non_coding_transcript_exon_variant 0.79
rrs 1472824 n.979T>A non_coding_transcript_exon_variant 0.69
rrs 1472825 n.980G>A non_coding_transcript_exon_variant 0.69
rrs 1472828 n.983T>C non_coding_transcript_exon_variant 0.69
rrs 1472836 n.991G>A non_coding_transcript_exon_variant 0.69
rrs 1472840 n.995A>C non_coding_transcript_exon_variant 0.69
rrs 1472851 n.1006A>G non_coding_transcript_exon_variant 0.73
rrs 1472856 n.1011T>C non_coding_transcript_exon_variant 0.73
rrs 1472860 n.1015C>G non_coding_transcript_exon_variant 0.73
rrs 1472861 n.1016G>T non_coding_transcript_exon_variant 0.73
rrs 1472862 n.1017T>C non_coding_transcript_exon_variant 0.73
rrs 1472863 n.1018T>C non_coding_transcript_exon_variant 0.73
rrs 1472873 n.1028C>T non_coding_transcript_exon_variant 0.79
rrs 1472875 n.1030T>G non_coding_transcript_exon_variant 0.79
rrs 1472880 n.1035G>A non_coding_transcript_exon_variant 0.88
rrs 1472956 n.1111T>C non_coding_transcript_exon_variant 0.85
rrs 1472958 n.1113A>G non_coding_transcript_exon_variant 0.85
rrs 1472973 n.1128A>G non_coding_transcript_exon_variant 0.87
rrs 1472974 n.1129A>G non_coding_transcript_exon_variant 0.84
rrs 1472977 n.1132G>C non_coding_transcript_exon_variant 0.84
rrs 1472987 n.1142G>A non_coding_transcript_exon_variant 0.87
rrs 1472988 n.1143T>C non_coding_transcript_exon_variant 0.87
rrs 1472990 n.1145A>G non_coding_transcript_exon_variant 0.87
rrs 1472996 n.1151T>C non_coding_transcript_exon_variant 0.91
rrs 1473026 n.1181T>C non_coding_transcript_exon_variant 0.95
rrs 1473055 n.1210C>T non_coding_transcript_exon_variant 0.95
rrs 1473056 n.1211A>T non_coding_transcript_exon_variant 0.95
rrs 1473062 n.1217T>G non_coding_transcript_exon_variant 0.96
rrs 1473068 n.1223A>G non_coding_transcript_exon_variant 0.94
rrs 1473089 n.1244A>T non_coding_transcript_exon_variant 0.95
rrs 1473091 n.1246G>A non_coding_transcript_exon_variant 0.95
rrs 1473100 n.1255G>A non_coding_transcript_exon_variant 0.98
rrs 1473110 n.1265T>G non_coding_transcript_exon_variant 0.98
rrs 1473111 n.1266A>G non_coding_transcript_exon_variant 0.98
rrs 1473120 n.1275C>T non_coding_transcript_exon_variant 0.98
rrs 1473121 n.1276T>C non_coding_transcript_exon_variant 0.98
rrs 1473122 n.1277T>A non_coding_transcript_exon_variant 0.98
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.98
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.98
rrs 1473201 n.1356A>T non_coding_transcript_exon_variant 0.98
rrs 1473202 n.1357C>T non_coding_transcript_exon_variant 0.98
rrs 1473252 n.1407T>C non_coding_transcript_exon_variant 1.0
rrs 1473276 n.1431A>G non_coding_transcript_exon_variant 1.0
rrs 1473283 n.1438T>C non_coding_transcript_exon_variant 0.97
rrs 1473315 n.1470T>C non_coding_transcript_exon_variant 0.96
rrs 1473316 n.1471C>T non_coding_transcript_exon_variant 0.96
rrl 1474001 n.344C>T non_coding_transcript_exon_variant 1.0
rrl 1474476 n.819C>G non_coding_transcript_exon_variant 0.5
rrl 1474483 n.826C>G non_coding_transcript_exon_variant 0.5
rrl 1474488 n.831G>T non_coding_transcript_exon_variant 0.5
rrl 1474496 n.839C>G non_coding_transcript_exon_variant 0.5
rrl 1474497 n.840G>A non_coding_transcript_exon_variant 0.5
rrl 1474506 n.849C>T non_coding_transcript_exon_variant 0.5
rrl 1474507 n.850G>T non_coding_transcript_exon_variant 0.5
rrl 1474516 n.859C>A non_coding_transcript_exon_variant 0.5
rrl 1474527 n.870T>C non_coding_transcript_exon_variant 0.5
rrl 1474528 n.871T>A non_coding_transcript_exon_variant 0.5
rrl 1474529 n.872A>G non_coding_transcript_exon_variant 0.6
rrl 1474537 n.880G>A non_coding_transcript_exon_variant 0.6
rrl 1474540 n.883T>C non_coding_transcript_exon_variant 0.6
rrl 1474541 n.884G>T non_coding_transcript_exon_variant 0.6
rrl 1474542 n.885A>G non_coding_transcript_exon_variant 0.6
rrl 1474551 n.894G>C non_coding_transcript_exon_variant 0.6
rrl 1474558 n.901G>T non_coding_transcript_exon_variant 0.71
rrl 1474626 n.969T>C non_coding_transcript_exon_variant 0.87
rrl 1474628 n.971C>T non_coding_transcript_exon_variant 0.87
rrl 1474632 n.975G>T non_coding_transcript_exon_variant 0.87
rrl 1474636 n.979A>T non_coding_transcript_exon_variant 0.87
rrl 1474637 n.980C>T non_coding_transcript_exon_variant 0.87
rrl 1474638 n.981C>G non_coding_transcript_exon_variant 0.87
rrl 1474639 n.982G>C non_coding_transcript_exon_variant 0.87
rrl 1474651 n.995delT non_coding_transcript_exon_variant 0.88
rrl 1474660 n.1003G>A non_coding_transcript_exon_variant 0.9
rrl 1474662 n.1005C>G non_coding_transcript_exon_variant 0.9
rrl 1474676 n.1019T>C non_coding_transcript_exon_variant 0.91
rrl 1474677 n.1020A>G non_coding_transcript_exon_variant 0.91
rrl 1474688 n.1031G>C non_coding_transcript_exon_variant 0.92
rrl 1474690 n.1033C>T non_coding_transcript_exon_variant 0.92
rrl 1474709 n.1053_1056delTGGT non_coding_transcript_exon_variant 0.95
rrl 1474717 n.1060_1061insGTGAG non_coding_transcript_exon_variant 0.95
rrl 1474722 n.1065T>C non_coding_transcript_exon_variant 0.96
rrl 1474734 n.1077G>T non_coding_transcript_exon_variant 0.96
rrl 1474736 n.1079C>T non_coding_transcript_exon_variant 0.96
rrl 1474751 n.1094G>A non_coding_transcript_exon_variant 1.0
rrl 1474760 n.1103A>G non_coding_transcript_exon_variant 1.0
rrl 1474777 n.1120T>G non_coding_transcript_exon_variant 1.0
rrl 1474779 n.1122G>A non_coding_transcript_exon_variant 1.0
rrl 1474780 n.1123C>T non_coding_transcript_exon_variant 1.0
rrl 1474783 n.1126G>A non_coding_transcript_exon_variant 1.0
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 1.0
rrl 1474801 n.1144G>A non_coding_transcript_exon_variant 1.0
rrl 1474802 n.1145T>C non_coding_transcript_exon_variant 1.0
rrl 1474823 n.1166C>G non_coding_transcript_exon_variant 1.0
rrl 1474831 n.1174A>C non_coding_transcript_exon_variant 0.93
rrl 1474896 n.1239A>T non_coding_transcript_exon_variant 1.0
rrl 1474904 n.1247G>C non_coding_transcript_exon_variant 1.0
rrl 1474905 n.1248T>C non_coding_transcript_exon_variant 1.0
rrl 1474913 n.1256T>C non_coding_transcript_exon_variant 1.0
rrl 1475129 n.1472G>A non_coding_transcript_exon_variant 1.0
rrl 1475171 n.1514C>T non_coding_transcript_exon_variant 1.0
rrl 1475175 n.1518G>C non_coding_transcript_exon_variant 1.0
rrl 1475499 n.1842C>T non_coding_transcript_exon_variant 1.0
rrl 1475508 n.1851A>T non_coding_transcript_exon_variant 1.0
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.75
rrl 1475532 n.1875A>G non_coding_transcript_exon_variant 0.75
rrl 1475539 n.1882A>T non_coding_transcript_exon_variant 0.75
rrl 1475542 n.1885A>G non_coding_transcript_exon_variant 0.75
rrl 1475544 n.1887A>T non_coding_transcript_exon_variant 0.75
rrl 1475545 n.1888T>G non_coding_transcript_exon_variant 0.75
rrl 1475599 n.1942A>G non_coding_transcript_exon_variant 0.75
rrl 1475601 n.1945_1947delGGA non_coding_transcript_exon_variant 0.75
rrl 1475606 n.1950delA non_coding_transcript_exon_variant 0.75
rrl 1475609 n.1952_1953insTTG non_coding_transcript_exon_variant 0.67
rrl 1475614 n.1957A>T non_coding_transcript_exon_variant 0.75
rrl 1475623 n.1966C>A non_coding_transcript_exon_variant 0.5
rrl 1475625 n.1968G>C non_coding_transcript_exon_variant 0.5
rrl 1475630 n.1973A>G non_coding_transcript_exon_variant 0.4
rrl 1475642 n.1985T>C non_coding_transcript_exon_variant 0.5
rrl 1475649 n.1992A>G non_coding_transcript_exon_variant 0.62
rrl 1475655 n.1998T>C non_coding_transcript_exon_variant 0.7
rrl 1475659 n.2002G>A non_coding_transcript_exon_variant 0.7
rrl 1475696 n.2039T>C non_coding_transcript_exon_variant 0.87
rrl 1475699 n.2042C>T non_coding_transcript_exon_variant 0.87
rrl 1475703 n.2046A>G non_coding_transcript_exon_variant 0.87
rrl 1475740 n.2083G>C non_coding_transcript_exon_variant 0.94
rrl 1475747 n.2090A>G non_coding_transcript_exon_variant 0.94
rrl 1475753 n.2096C>G non_coding_transcript_exon_variant 0.94
rrl 1475758 n.2101A>G non_coding_transcript_exon_variant 0.93
rrl 1475760 n.2103C>T non_coding_transcript_exon_variant 0.93
rrl 1475761 n.2105delG non_coding_transcript_exon_variant 0.93
rrl 1475769 n.2112T>C non_coding_transcript_exon_variant 0.94
rrl 1475775 n.2118G>T non_coding_transcript_exon_variant 0.95
rrl 1475781 n.2124T>C non_coding_transcript_exon_variant 0.95
rrl 1475788 n.2131C>G non_coding_transcript_exon_variant 0.95
rrl 1475883 n.2226A>G non_coding_transcript_exon_variant 1.0
rrl 1475900 n.2243A>G non_coding_transcript_exon_variant 1.0
rrl 1475902 n.2245T>C non_coding_transcript_exon_variant 1.0
rrl 1475906 n.2249C>T non_coding_transcript_exon_variant 1.0
rrl 1475937 n.2280A>T non_coding_transcript_exon_variant 1.0
rrl 1475943 n.2286G>A non_coding_transcript_exon_variant 1.0
rrl 1475952 n.2295A>G non_coding_transcript_exon_variant 1.0
rrl 1475970 n.2313C>T non_coding_transcript_exon_variant 1.0
rrl 1475977 n.2320A>G non_coding_transcript_exon_variant 1.0
rrl 1475978 n.2321C>T non_coding_transcript_exon_variant 1.0
rrl 1475982 n.2325G>A non_coding_transcript_exon_variant 1.0
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 1.0
rrl 1475997 n.2340A>T non_coding_transcript_exon_variant 1.0
rrl 1476001 n.2344T>C non_coding_transcript_exon_variant 1.0
rrl 1476015 n.2358G>C non_coding_transcript_exon_variant 1.0
rrl 1476025 n.2368G>T non_coding_transcript_exon_variant 1.0
rrl 1476035 n.2378_2379insC non_coding_transcript_exon_variant 1.0
rrl 1476044 n.2387T>G non_coding_transcript_exon_variant 1.0
rrl 1476045 n.2388G>T non_coding_transcript_exon_variant 1.0
rrl 1476049 n.2392C>T non_coding_transcript_exon_variant 1.0
rrl 1476058 n.2401T>C non_coding_transcript_exon_variant 1.0
rrl 1476071 n.2414C>G non_coding_transcript_exon_variant 1.0
rrl 1476076 n.2419A>G non_coding_transcript_exon_variant 1.0
rrl 1476164 n.2507A>G non_coding_transcript_exon_variant 0.8
rrl 1476165 n.2508T>G non_coding_transcript_exon_variant 0.8
rrl 1476194 n.2537A>G non_coding_transcript_exon_variant 0.83
rrl 1476200 n.2543A>T non_coding_transcript_exon_variant 0.83
rrl 1476201 n.2544C>T non_coding_transcript_exon_variant 0.83
rrl 1476214 n.2557G>T non_coding_transcript_exon_variant 0.86
rrl 1476215 n.2558C>T non_coding_transcript_exon_variant 0.86
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.88
rrl 1476245 n.2588C>T non_coding_transcript_exon_variant 0.89
rrl 1476251 n.2594T>C non_coding_transcript_exon_variant 0.88
rrl 1476252 n.2595T>G non_coding_transcript_exon_variant 0.88
rrl 1476255 n.2598A>G non_coding_transcript_exon_variant 0.88
rrl 1476256 n.2599A>G non_coding_transcript_exon_variant 0.88
rrl 1476260 n.2603A>G non_coding_transcript_exon_variant 0.89
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.89
rrl 1476294 n.2637A>G non_coding_transcript_exon_variant 0.89
rrl 1476295 n.2638C>G non_coding_transcript_exon_variant 0.89
rrl 1476296 n.2639C>T non_coding_transcript_exon_variant 0.89
rrl 1476297 n.2640C>G non_coding_transcript_exon_variant 0.89
rrl 1476298 n.2641C>G non_coding_transcript_exon_variant 0.89
rrl 1476300 n.2643G>T non_coding_transcript_exon_variant 0.89
rrl 1476301 n.2644A>T non_coding_transcript_exon_variant 0.89
rrl 1476309 n.2652G>C non_coding_transcript_exon_variant 0.89
rrl 1476311 n.2654G>C non_coding_transcript_exon_variant 0.89
rrl 1476312 n.2655T>C non_coding_transcript_exon_variant 0.89
rrl 1476428 n.2771C>T non_coding_transcript_exon_variant 0.96
rrl 1476429 n.2772A>C non_coding_transcript_exon_variant 0.95
rrl 1476466 n.2809C>T non_coding_transcript_exon_variant 0.95
rrl 1476506 n.2849T>C non_coding_transcript_exon_variant 0.93
rrl 1476515 n.2858C>T non_coding_transcript_exon_variant 0.91
rrl 1476517 n.2860C>T non_coding_transcript_exon_variant 0.91
rrl 1476524 n.2867C>A non_coding_transcript_exon_variant 0.91
rrl 1476525 n.2868A>G non_coding_transcript_exon_variant 0.91
rrl 1476528 n.2871A>G non_coding_transcript_exon_variant 0.91
rrl 1476529 n.2872A>T non_coding_transcript_exon_variant 0.91
rrl 1476536 n.2879G>A non_coding_transcript_exon_variant 1.0
rrl 1476538 n.2881A>G non_coding_transcript_exon_variant 1.0
rrl 1476539 n.2882A>G non_coding_transcript_exon_variant 1.0
rrl 1476540 n.2883C>G non_coding_transcript_exon_variant 1.0
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 1.0
rrl 1476585 n.2928A>G non_coding_transcript_exon_variant 1.0
rrl 1476594 n.2937C>T non_coding_transcript_exon_variant 1.0
rrl 1476596 n.2939C>T non_coding_transcript_exon_variant 1.0
rrl 1476601 n.2944G>A non_coding_transcript_exon_variant 1.0
rrl 1476607 n.2950C>T non_coding_transcript_exon_variant 1.0
rrl 1476608 n.2951C>G non_coding_transcript_exon_variant 1.0
rrl 1476614 n.2957A>T non_coding_transcript_exon_variant 0.83
rrl 1476616 n.2959A>G non_coding_transcript_exon_variant 0.83
rrl 1476619 n.2962C>T non_coding_transcript_exon_variant 0.83
rrl 1476628 n.2971T>G non_coding_transcript_exon_variant 0.83
rrl 1476629 n.2972C>A non_coding_transcript_exon_variant 0.83
rrl 1476630 n.2973A>G non_coding_transcript_exon_variant 0.83
rrl 1476661 n.3004A>G non_coding_transcript_exon_variant 0.67
rpsA 1833694 c.153G>C synonymous_variant 0.15
rpsA 1833697 c.156C>G synonymous_variant 0.14
rpsA 1833709 c.168C>T synonymous_variant 0.13
rpsA 1833724 c.183C>T synonymous_variant 0.14
rpsA 1833727 c.186G>C synonymous_variant 0.15
rpsA 1833733 c.192C>G synonymous_variant 0.15
rpsA 1833734 p.Ala65Ser missense_variant 0.15
rpsA 1833742 c.201A>G synonymous_variant 0.13
rpsA 1833745 c.204G>C synonymous_variant 0.14
rpsA 1833748 c.207C>G synonymous_variant 0.14
rpsA 1833781 c.240T>C synonymous_variant 0.2
rpsA 1833782 p.Ser81Ala missense_variant 0.2
rpsA 1833797 p.Val86Ile missense_variant 0.2
rpsA 1833802 c.261A>G synonymous_variant 0.2
rpsA 1833811 c.270G>C synonymous_variant 0.2
rpsA 1833815 p.Thr92Gln missense_variant 0.2
rpsA 1833829 c.288A>G synonymous_variant 0.3
rpsA 1833832 c.291G>A synonymous_variant 0.33
rpsA 1833838 c.297G>C synonymous_variant 0.38
rpsA 1833841 c.300C>G synonymous_variant 0.38
rpsA 1833850 c.309C>G synonymous_variant 0.25
rpsA 1833856 c.315A>G synonymous_variant 0.33
rpsA 1833862 c.321G>C synonymous_variant 0.29
rpsA 1833874 c.333T>G synonymous_variant 0.5
rpsA 1833893 p.Ala118Lys missense_variant 0.33
rpsA 1833896 p.Leu119Ile missense_variant 0.36
rpsA 1833904 c.363G>A synonymous_variant 0.27
rpsA 1833905 p.Lys122Glu missense_variant 0.27
rpsA 1833910 c.371_372delAG frameshift_variant 0.3
rpsA 1833915 c.374_375insAT frameshift_variant 0.38
rpsA 1833921 p.Lys127Thr missense_variant 0.38
rpsA 1833925 c.384C>T synonymous_variant 0.38
rpsA 1833928 c.387G>C synonymous_variant 0.38
rpsA 1833952 c.411C>T synonymous_variant 0.45
rpsA 1833955 c.414G>C synonymous_variant 0.36
rpsA 1833970 c.429G>C synonymous_variant 0.36
rpsA 1833973 c.432G>C synonymous_variant 0.36
rpsA 1833979 c.438T>C synonymous_variant 0.36
rpsA 1833985 c.444G>C synonymous_variant 0.36
rpsA 1833988 c.447C>G synonymous_variant 0.36
rpsA 1833994 c.453G>C synonymous_variant 0.36
rpsA 1834000 c.459G>C synonymous_variant 0.36
rpsA 1834012 c.471G>C synonymous_variant 0.33
rpsA 1834015 c.474G>C synonymous_variant 0.33
rpsA 1834024 c.483G>C synonymous_variant 0.33
rpsA 1834034 p.Ile165Val missense_variant 0.38
rpsA 1834046 p.Ile169Leu missense_variant 0.29
rpsA 1834054 c.513C>G synonymous_variant 0.29
rpsA 1834093 c.552G>C synonymous_variant 0.33
rpsA 1834102 c.561T>C synonymous_variant 0.42
rpsA 1834105 c.564C>T synonymous_variant 0.42
rpsA 1834210 c.669C>T synonymous_variant 0.22
rpsA 1834213 c.672G>C synonymous_variant 0.22
rpsA 1834219 c.678C>G synonymous_variant 0.22
rpsA 1834222 c.681T>C synonymous_variant 0.22
rpsA 1834225 c.684C>G synonymous_variant 0.22
rpsA 1834228 c.687C>T synonymous_variant 0.22
rpsA 1834231 c.690T>C synonymous_variant 0.2
rpsA 1834234 c.693G>C synonymous_variant 0.3
rpsA 1834246 c.705G>C synonymous_variant 0.27
rpsA 1834249 c.708T>C synonymous_variant 0.33
rpsA 1834255 c.714C>T synonymous_variant 0.22
rpsA 1834261 c.720A>G synonymous_variant 0.43
rpsA 1834264 c.723G>C synonymous_variant 0.43
rpsA 1834294 c.753G>C synonymous_variant 0.57
rpsA 1834298 p.Gln253Glu missense_variant 0.57
rpsA 1834303 c.762T>C synonymous_variant 0.57
rpsA 1834306 c.765T>C synonymous_variant 0.57
rpsA 1834307 p.Asp256Gln missense_variant 0.57
rpsA 1834327 c.786G>T synonymous_variant 0.5
rpsA 1834336 c.795C>G synonymous_variant 0.44
rpsA 1834348 c.807T>C synonymous_variant 0.44
rpsA 1834354 c.813G>C synonymous_variant 0.44
rpsA 1834357 c.816T>C synonymous_variant 0.44
rpsA 1834360 c.819G>C synonymous_variant 0.44
rpsA 1834361 c.820T>C synonymous_variant 0.44
rpsA 1834366 c.825A>G synonymous_variant 0.44
rpsA 1834369 c.828C>G synonymous_variant 0.5
rpsA 1834378 c.837T>C synonymous_variant 0.5
rpsA 1834395 p.Arg285Gln missense_variant 0.56
rpsA 1834399 p.His286Gln missense_variant 0.56
rpsA 1834411 c.870T>C synonymous_variant 0.56
rpsA 1834415 p.Ala292Gln missense_variant 0.5
rpsA 1834423 c.882G>C synonymous_variant 0.45
rpsA 1834427 p.Ile296Val missense_variant 0.45
rpsA 1834435 c.894G>C synonymous_variant 0.45
rpsA 1834447 c.906C>G synonymous_variant 0.45
rpsA 1834451 c.910T>C synonymous_variant 0.45
rpsA 1834468 c.927A>G synonymous_variant 0.25
rpsA 1834480 c.939C>G synonymous_variant 0.25
rpsA 1834483 p.Glu314Asp missense_variant 0.25
rpsA 1834489 c.948T>C synonymous_variant 0.27
rpsA 1834498 c.957C>T synonymous_variant 0.27
rpsA 1834504 c.963G>C synonymous_variant 0.3
rpsA 1834528 c.987T>C synonymous_variant 0.2
tlyA 1917972 c.33A>G synonymous_variant 1.0
katG 2153961 p.Gln717His missense_variant 0.22
PPE35 2168149 p.Pro822Ser missense_variant 1.0
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
kasA 2519035 c.921C>T synonymous_variant 0.33
eis 2715493 c.-161G>T upstream_gene_variant 0.17
ribD 2986743 c.-96G>T upstream_gene_variant 0.91
Rv2752c 3065554 p.Pro213Leu missense_variant 1.0
fprA 3474259 p.Gly85Ser missense_variant 0.5
fprA 3474578 p.Ile191Thr missense_variant 0.2
rpoA 3877923 p.Asp195Glu missense_variant 1.0
rpoA 3878065 p.Pro148Leu missense_variant 0.25
clpC1 4039022 c.1683A>G synonymous_variant 0.17
clpC1 4039067 p.Ser546Gly missense_variant 0.18
clpC1 4039079 c.1626C>G synonymous_variant 0.18
clpC1 4039085 c.1620A>G synonymous_variant 0.18
clpC1 4039091 c.1614G>T synonymous_variant 0.2
clpC1 4039097 c.1608G>T synonymous_variant 0.2
clpC1 4039106 c.1599G>C synonymous_variant 0.2
clpC1 4039112 c.1593C>G synonymous_variant 0.2
clpC1 4039586 c.1119G>C synonymous_variant 0.33
clpC1 4039589 c.1116G>C synonymous_variant 0.29
clpC1 4039592 c.1113G>C synonymous_variant 0.25
clpC1 4039616 c.1089G>C synonymous_variant 0.33
clpC1 4039622 c.1083C>G synonymous_variant 0.31
clpC1 4039640 c.1065C>G synonymous_variant 0.31
clpC1 4039647 p.Glu353Pro missense_variant 0.25
clpC1 4039651 p.Val352Leu missense_variant 0.27
clpC1 4039654 p.Thr351Ser missense_variant 0.25
clpC1 4039661 p.Gly348Ala missense_variant 0.25
clpC1 4039664 c.1041G>C synonymous_variant 0.25
clpC1 4039670 p.Val345Ile missense_variant 0.25
clpC1 4039673 c.1032G>C synonymous_variant 0.27
clpC1 4039691 c.1014G>C synonymous_variant 0.27
clpC1 4039694 c.1011G>C synonymous_variant 0.27
clpC1 4039697 c.1008C>G synonymous_variant 0.27
clpC1 4039709 p.Ile332Leu missense_variant 0.3
clpC1 4039714 p.Tyr331His missense_variant 0.21
clpC1 4039724 c.981A>G synonymous_variant 0.21
clpC1 4039729 p.Asp326Asn missense_variant 0.79
clpC1 4039730 c.975C>G synonymous_variant 0.21
clpC1 4039739 c.966C>G synonymous_variant 0.2
clpC1 4039742 c.963C>T synonymous_variant 0.2
clpC1 4039748 c.957G>C synonymous_variant 0.21
clpC1 4039751 c.954A>G synonymous_variant 0.23
clpC1 4039757 c.948A>G synonymous_variant 0.25
clpC1 4039766 c.939T>C synonymous_variant 0.25
clpC1 4039769 c.936C>G synonymous_variant 0.25
clpC1 4039773 p.Lys311Met missense_variant 0.25
clpC1 4039778 c.927A>G synonymous_variant 0.25
clpC1 4039781 c.924G>C synonymous_variant 0.25
clpC1 4039787 c.916_918delTCGinsAGC synonymous_variant 0.25
clpC1 4039790 c.915C>G synonymous_variant 0.25
clpC1 4039802 c.903G>C synonymous_variant 0.25
clpC1 4039817 c.888A>T synonymous_variant 0.47
clpC1 4039820 c.885T>G synonymous_variant 0.47
clpC1 4039831 c.874T>C synonymous_variant 0.44
clpC1 4039832 c.873C>G synonymous_variant 0.41
clpC1 4039850 c.855T>C synonymous_variant 0.44
clpC1 4039865 c.840T>C synonymous_variant 0.5
clpC1 4039875 p.Asn277Arg missense_variant 0.53
clpC1 4039898 c.807C>G synonymous_variant 0.42
clpC1 4039904 c.801A>G synonymous_variant 0.4
clpC1 4039929 c.775_776delAGinsTC synonymous_variant 0.38
clpC1 4039931 c.774T>C synonymous_variant 0.38
clpC1 4039934 c.771G>C synonymous_variant 0.38
clpC1 4039937 c.768G>C synonymous_variant 0.38
clpC1 4039943 p.Ser254Ala missense_variant 0.38
clpC1 4039946 c.759A>C synonymous_variant 0.38
clpC1 4039949 c.756G>C synonymous_variant 0.36
clpC1 4039952 c.753T>C synonymous_variant 0.36
clpC1 4039958 c.747G>C synonymous_variant 0.36
clpC1 4039967 p.Gln246His missense_variant 0.39
clpC1 4039982 c.723G>C synonymous_variant 0.41
clpC1 4040000 p.His235Lys missense_variant 0.41
clpC1 4040003 c.702G>C synonymous_variant 0.41
clpC1 4040018 c.687G>C synonymous_variant 0.38
clpC1 4040021 c.684A>C synonymous_variant 0.39
clpC1 4040024 c.681A>G synonymous_variant 0.39
clpC1 4040033 c.672G>C synonymous_variant 0.39
clpC1 4040057 c.648C>T synonymous_variant 0.33
clpC1 4040063 c.642G>C synonymous_variant 0.26
clpC1 4040291 c.414G>C synonymous_variant 0.29
clpC1 4040300 c.405C>G synonymous_variant 0.25
embC 4240555 p.Met231Ile missense_variant 1.0
embC 4242044 p.Ile728Val missense_variant 0.2
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embA 4245943 p.Arg904His missense_variant 0.33
embB 4247573 p.Asp354Asn missense_variant 0.4
embB 4248506 p.Gly665Trp missense_variant 0.25
aftB 4269075 c.-239T>A upstream_gene_variant 0.13
ethA 4326364 p.Lys370Asn missense_variant 0.13
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
gid 4408431 c.-229G>A upstream_gene_variant 0.4
Rv3083 3448507 c.5_*1408del frameshift_variant&stop_lost&splice_region_variant 1.0