Run ID: ERR4769457
Sample name:
Date: 2024-04-15T09:16:18.453404
Number of reads: 82228
Percentage reads mapped: 2.1
Median coverage: 1.0
Strain: lineage4.9
Spoligotype:
Drug-resistance: Other
Lineage | Family | RDs | Frequency |
---|---|---|---|
lineage4 | Euro-American | None | 0.98 |
lineage4.9 | Euro-American (H37Rv-like) | None | 0.99 |
Drug | Resistance | Supporting mutations | WHO confidence | Comment |
---|---|---|---|---|
rifampicin | ||||
isoniazid | ||||
ethambutol | embB | p.Ala356Val | Uncertain significance | Mutation from literature |
pyrazinamide | ||||
streptomycin | ||||
fluoroquinolones | ||||
moxifloxacin | ||||
ofloxacin | ||||
levofloxacin | ||||
ciprofloxacin | ||||
aminoglycosides | ||||
amikacin | ||||
capreomycin | ||||
kanamycin | ||||
cycloserine | ||||
ethionamide | ||||
clofazimine | ||||
para-aminosalicylic_acid | ||||
delamanid | ||||
bedaquiline | ||||
linezolid |
Gene | Chromosome position | Mutation | Type | Estimated fraction | Drugs | Confidence | Comment |
---|---|---|---|---|---|---|---|
embB | 4247580 | p.Ala356Val | missense_variant | 0.9 | ethambutol | Uncertain significance | Mutation from literature |
Gene | Chromosome position | Mutation | Type | Estimated fraction | Drugs | Confidence |
---|---|---|---|---|---|---|
gyrA | 6676 | c.-626T>G | upstream_gene_variant | 1.0 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 6700 | c.-602T>C | upstream_gene_variant | 1.0 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 6703 | c.-599G>C | upstream_gene_variant | 1.0 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 6706 | c.-596G>A | upstream_gene_variant | 1.0 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 6709 | c.-593A>G | upstream_gene_variant | 1.0 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 6712 | c.-590G>C | upstream_gene_variant | 0.9 | levofloxacin | |
moxifloxacin | ||||||
gyrB | 6715 | c.1476C>G | synonymous_variant | 1.0 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 7394 | c.93T>C | synonymous_variant | 0.92 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | ||||||
gyrA | 7418 | c.117C>G | synonymous_variant | 0.92 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7421 | c.120G>A | synonymous_variant | 0.92 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7427 | c.126G>C | synonymous_variant | 0.91 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7442 | c.141G>C | synonymous_variant | 0.91 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7451 | c.150C>G | synonymous_variant | 0.91 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7457 | c.156T>C | synonymous_variant | 0.91 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7472 | c.171T>C | synonymous_variant | 0.91 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | ||||||
gyrA | 7475 | c.174A>G | synonymous_variant | 0.91 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 7484 | c.183T>C | synonymous_variant | 0.91 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7784 | c.483A>G | synonymous_variant | 1.0 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7799 | c.498A>G | synonymous_variant | 1.0 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 7814 | c.513C>G | synonymous_variant | 1.0 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 7832 | c.531G>C | synonymous_variant | 1.0 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7859 | c.558A>G | synonymous_variant | 1.0 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7865 | c.564T>C | synonymous_variant | 1.0 | levofloxacin | |
moxifloxacin | ||||||
mshA | 575795 | p.Ile150Val | missense_variant | 1.0 | ethionamide | |
isoniazid | ||||||
mshA | 575803 | c.456C>T | synonymous_variant | 1.0 | ethionamide | |
isoniazid | Not assoc w R - Interim | |||||
mshA | 575818 | c.471G>C | synonymous_variant | 1.0 | ethionamide | |
isoniazid | ||||||
mshA | 575840 | c.494dupC | frameshift_variant | 1.0 | ethionamide | Uncertain significance |
isoniazid | Uncertain significance | |||||
mshA | 575844 | c.498delC | frameshift_variant | 1.0 | ethionamide | Uncertain significance |
isoniazid | Uncertain significance | |||||
mshA | 575864 | c.517T>C | synonymous_variant | 1.0 | ethionamide | |
isoniazid | ||||||
rpoB | 761282 | c.1476C>G | synonymous_variant | 0.9 | rifampicin | |
rpoB | 762338 | c.2532T>C | synonymous_variant | 1.0 | rifampicin | |
rpoB | 762347 | c.2541T>C | synonymous_variant | 1.0 | rifampicin | |
rpoB | 762362 | p.Glu852Asp | missense_variant | 1.0 | rifampicin | |
rpoB | 762369 | c.2563T>C | synonymous_variant | 1.0 | rifampicin | |
rpoC | 762374 | c.-996G>C | upstream_gene_variant | 1.0 | rifampicin | |
rpoC | 762380 | c.-990T>G | upstream_gene_variant | 1.0 | rifampicin | |
rpoC | 762398 | c.-972T>C | upstream_gene_variant | 1.0 | rifampicin | |
rpoC | 762401 | c.-969G>C | upstream_gene_variant | 1.0 | rifampicin | |
rpoC | 762407 | c.-963G>C | upstream_gene_variant | 1.0 | rifampicin | |
rpoB | 762410 | c.2604T>G | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
rpoB | 762416 | c.2610A>G | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
rpoB | 762452 | c.2646G>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
rpoB | 762470 | c.2664G>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
rpoB | 763040 | c.3234C>G | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
rpoC | 763528 | c.159G>A | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
rpoC | 763546 | c.177A>G | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
rpoC | 763570 | c.201G>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
rpoC | 763594 | c.225C>T | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
rpoC | 763603 | c.234C>T | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
rpoC | 763618 | c.249C>T | synonymous_variant | 1.0 | rifampicin | |
rpoC | 764458 | c.1089G>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
rpoC | 764461 | c.1092A>G | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
rpoC | 764497 | c.1128A>G | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
rpoC | 764503 | c.1134G>C | synonymous_variant | 1.0 | rifampicin | |
rpoC | 764521 | c.1152T>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
rpoC | 764527 | c.1158C>T | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
rpoC | 764539 | c.1170C>G | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
rpoC | 764548 | c.1179G>C | synonymous_variant | 1.0 | rifampicin | |
rpoC | 764566 | c.1197C>G | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
rpoC | 764593 | c.1224C>T | synonymous_variant | 1.0 | rifampicin | |
rpoC | 764632 | c.1263T>C | synonymous_variant | 0.94 | rifampicin | Not assoc w R - Interim |
rpoC | 764650 | c.1281G>T | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
rpoC | 764668 | c.1299C>T | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
rpoC | 764713 | c.1344G>A | synonymous_variant | 1.0 | rifampicin | |
rpoC | 764746 | c.1377G>T | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
rpoC | 764752 | c.1383G>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
rpoC | 764758 | c.1389C>G | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
rpoC | 764764 | c.1395T>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
rpoC | 764791 | c.1422C>A | synonymous_variant | 1.0 | rifampicin | |
rpoC | 764815 | c.1446A>G | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
rpoC | 764824 | c.1455T>C | synonymous_variant | 0.91 | rifampicin | Not assoc w R - Interim |
rpoC | 764827 | c.1458G>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
rpoC | 764858 | c.1489T>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
rpoC | 764863 | c.1494G>C | synonymous_variant | 0.92 | rifampicin | Not assoc w R - Interim |
rpoC | 764869 | c.1500C>T | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
rpoC | 764888 | c.1519T>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
rpoC | 764902 | c.1533C>G | synonymous_variant | 0.9 | rifampicin | |
rpoC | 764911 | c.1542A>G | synonymous_variant | 1.0 | rifampicin | |
rpoC | 764912 | p.Met515Gln | missense_variant | 1.0 | rifampicin | Uncertain significance |
rpoC | 764923 | c.1554A>G | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
rpoC | 764948 | c.1579T>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
rpoC | 764962 | c.1593G>C | synonymous_variant | 0.92 | rifampicin | Not assoc w R - Interim |
rpoC | 764968 | c.1599T>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
rpoC | 764995 | c.1626C>A | synonymous_variant | 1.0 | rifampicin | |
rpoC | 764998 | c.1629G>C | synonymous_variant | 1.0 | rifampicin | |
rpoC | 765445 | c.2076G>T | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
rpoC | 765453 | p.Ala695Val | missense_variant | 1.0 | rifampicin | Uncertain significance |
rpoC | 765562 | c.2193G>C | synonymous_variant | 1.0 | rifampicin | |
rpoC | 765607 | c.2238C>G | synonymous_variant | 1.0 | rifampicin | |
rpoC | 765611 | p.His748Ser | missense_variant | 1.0 | rifampicin | Uncertain significance |
rpoC | 765619 | c.2250G>A | synonymous_variant | 1.0 | rifampicin | |
rpoC | 765628 | c.2259G>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
rpoC | 765700 | c.2331T>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
rpoC | 765718 | p.Asp783Glu | missense_variant | 1.0 | rifampicin | Uncertain significance |
rpoC | 765811 | c.2442T>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
rpoC | 765814 | c.2445A>G | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
rpoC | 765826 | c.2457T>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
rpoC | 765835 | c.2466C>T | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
rpoC | 765850 | c.2481G>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
rpoC | 765871 | c.2502T>G | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
rpoC | 765875 | p.Val836Ile | missense_variant | 1.0 | rifampicin | Uncertain significance |
rpoC | 765904 | c.2535C>G | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
rpoC | 765934 | c.2565C>T | synonymous_variant | 1.0 | rifampicin | |
rpoC | 765967 | c.2598C>T | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
rpsL | 781808 | c.249C>T | synonymous_variant | 1.0 | streptomycin | |
rpsL | 781811 | c.252C>T | synonymous_variant | 1.0 | streptomycin | |
rpsL | 781832 | c.273T>G | synonymous_variant | 1.0 | streptomycin | |
rpsL | 781868 | c.309T>C | synonymous_variant | 1.0 | streptomycin | |
rrs | 1471923 | n.78T>C | non_coding_transcript_exon_variant | 1.0 | streptomycin | Uncertain significance |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1471925 | n.80T>C | non_coding_transcript_exon_variant | 1.0 | streptomycin | |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1471932 | n.87A>G | non_coding_transcript_exon_variant | 1.0 | streptomycin | |
kanamycin | ||||||
capreomycin | ||||||
amikacin | ||||||
rrs | 1471934 | n.89A>G | non_coding_transcript_exon_variant | 1.0 | streptomycin | Uncertain significance |
kanamycin | ||||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1471985 | n.140T>C | non_coding_transcript_exon_variant | 1.0 | streptomycin | Uncertain significance |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1471986 | n.141C>T | non_coding_transcript_exon_variant | 1.0 | streptomycin | Uncertain significance |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1471996 | n.151C>T | non_coding_transcript_exon_variant | 1.0 | streptomycin | |
kanamycin | ||||||
capreomycin | ||||||
amikacin | ||||||
rrs | 1472029 | n.184C>T | non_coding_transcript_exon_variant | 1.0 | streptomycin | Uncertain significance |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472041 | n.196C>T | non_coding_transcript_exon_variant | 1.0 | streptomycin | Uncertain significance |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472042 | n.197T>C | non_coding_transcript_exon_variant | 1.0 | streptomycin | |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472053 | n.211_212delGC | non_coding_transcript_exon_variant | 1.0 | streptomycin | |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472061 | n.216A>T | non_coding_transcript_exon_variant | 1.0 | streptomycin | |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472075 | n.230A>G | non_coding_transcript_exon_variant | 1.0 | streptomycin | |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472108 | n.263C>T | non_coding_transcript_exon_variant | 1.0 | streptomycin | Uncertain significance |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472286 | n.441C>G | non_coding_transcript_exon_variant | 1.0 | streptomycin | |
kanamycin | ||||||
capreomycin | ||||||
amikacin | ||||||
rrs | 1472287 | n.442C>T | non_coding_transcript_exon_variant | 1.0 | streptomycin | |
kanamycin | ||||||
capreomycin | ||||||
amikacin | ||||||
rrs | 1472292 | n.447A>G | non_coding_transcript_exon_variant | 1.0 | streptomycin | Uncertain significance |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472327 | n.482G>A | non_coding_transcript_exon_variant | 1.0 | streptomycin | |
kanamycin | ||||||
capreomycin | ||||||
amikacin | ||||||
rrs | 1472328 | n.483G>C | non_coding_transcript_exon_variant | 1.0 | streptomycin | Uncertain significance |
kanamycin | ||||||
capreomycin | ||||||
amikacin | ||||||
rrs | 1472438 | n.593T>C | non_coding_transcript_exon_variant | 1.0 | streptomycin | Uncertain significance |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472446 | n.601T>A | non_coding_transcript_exon_variant | 1.0 | streptomycin | |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472452 | n.607G>A | non_coding_transcript_exon_variant | 1.0 | streptomycin | |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472456 | n.611T>C | non_coding_transcript_exon_variant | 1.0 | streptomycin | |
kanamycin | ||||||
capreomycin | ||||||
amikacin | ||||||
rrs | 1472464 | n.619A>G | non_coding_transcript_exon_variant | 1.0 | streptomycin | Uncertain significance |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472489 | n.644A>G | non_coding_transcript_exon_variant | 1.0 | streptomycin | Uncertain significance |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472498 | n.653C>T | non_coding_transcript_exon_variant | 1.0 | streptomycin | Uncertain significance |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472683 | n.838_839insTA | non_coding_transcript_exon_variant | 1.0 | streptomycin | |
kanamycin | ||||||
capreomycin | ||||||
amikacin | ||||||
rrs | 1472973 | n.1128A>T | non_coding_transcript_exon_variant | 0.91 | streptomycin | |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1473104 | n.1259C>T | non_coding_transcript_exon_variant | 0.95 | streptomycin | Uncertain significance |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1473111 | n.1266A>T | non_coding_transcript_exon_variant | 1.0 | streptomycin | |
kanamycin | ||||||
capreomycin | ||||||
amikacin | ||||||
rrs | 1473123 | n.1278A>T | non_coding_transcript_exon_variant | 1.0 | streptomycin | Uncertain significance |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrl | 1473770 | n.113T>G | non_coding_transcript_exon_variant | 1.0 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1473788 | n.131A>G | non_coding_transcript_exon_variant | 1.0 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1473806 | n.149C>T | non_coding_transcript_exon_variant | 1.0 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1473807 | n.150T>C | non_coding_transcript_exon_variant | 1.0 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1473812 | n.155G>T | non_coding_transcript_exon_variant | 1.0 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1473814 | n.157A>C | non_coding_transcript_exon_variant | 1.0 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1473815 | n.158T>G | non_coding_transcript_exon_variant | 1.0 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1473816 | n.159C>G | non_coding_transcript_exon_variant | 1.0 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1473822 | n.165A>G | non_coding_transcript_exon_variant | 1.0 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1473839 | n.182G>T | non_coding_transcript_exon_variant | 1.0 | capreomycin | |
linezolid | ||||||
rrl | 1473877 | n.220G>A | non_coding_transcript_exon_variant | 1.0 | capreomycin | |
linezolid | ||||||
rrl | 1473899 | n.242A>G | non_coding_transcript_exon_variant | 1.0 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1473916 | n.259C>A | non_coding_transcript_exon_variant | 1.0 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474083 | n.426C>T | non_coding_transcript_exon_variant | 1.0 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1474089 | n.432C>T | non_coding_transcript_exon_variant | 1.0 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1474093 | n.436G>A | non_coding_transcript_exon_variant | 1.0 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1474103 | n.446A>T | non_coding_transcript_exon_variant | 1.0 | capreomycin | |
linezolid | ||||||
rrl | 1474105 | n.448delTinsCA | non_coding_transcript_exon_variant | 1.0 | capreomycin | |
linezolid | ||||||
rrl | 1474108 | n.451C>G | non_coding_transcript_exon_variant | 1.0 | capreomycin | |
linezolid | ||||||
rrl | 1474110 | n.453A>T | non_coding_transcript_exon_variant | 1.0 | capreomycin | |
linezolid | ||||||
rrl | 1474116 | n.459G>A | non_coding_transcript_exon_variant | 1.0 | capreomycin | |
linezolid | ||||||
rrl | 1474127 | n.470G>A | non_coding_transcript_exon_variant | 1.0 | capreomycin | |
linezolid | ||||||
rrl | 1474139 | n.482C>T | non_coding_transcript_exon_variant | 1.0 | capreomycin | |
linezolid | ||||||
rrl | 1474151 | n.494C>T | non_coding_transcript_exon_variant | 1.0 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474174 | n.517A>G | non_coding_transcript_exon_variant | 1.0 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474181 | n.524C>T | non_coding_transcript_exon_variant | 1.0 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1474201 | n.544T>C | non_coding_transcript_exon_variant | 1.0 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474202 | n.545T>G | non_coding_transcript_exon_variant | 1.0 | capreomycin | |
linezolid | ||||||
rrl | 1474249 | n.592G>T | non_coding_transcript_exon_variant | 1.0 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474263 | n.606G>A | non_coding_transcript_exon_variant | 1.0 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1474287 | n.630_647delTCCTTTTCCTCTCCGGAGinsCTCTCTTT | non_coding_transcript_exon_variant | 1.0 | capreomycin | |
linezolid | ||||||
rrl | 1474308 | n.651G>T | non_coding_transcript_exon_variant | 1.0 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474310 | n.653T>G | non_coding_transcript_exon_variant | 1.0 | capreomycin | |
linezolid | ||||||
rrl | 1474350 | n.693G>C | non_coding_transcript_exon_variant | 1.0 | capreomycin | |
linezolid | ||||||
rrl | 1474351 | n.694G>C | non_coding_transcript_exon_variant | 1.0 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1474353 | n.696A>G | non_coding_transcript_exon_variant | 1.0 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474356 | n.699T>C | non_coding_transcript_exon_variant | 1.0 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1474362 | n.705A>G | non_coding_transcript_exon_variant | 1.0 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474708 | n.1052dupG | non_coding_transcript_exon_variant | 0.94 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1474711 | n.1054_1055insA | non_coding_transcript_exon_variant | 0.94 | capreomycin | |
linezolid | ||||||
rrl | 1474715 | n.1061delA | non_coding_transcript_exon_variant | 0.94 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1474753 | n.1096A>G | non_coding_transcript_exon_variant | 0.94 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1474760 | n.1103A>G | non_coding_transcript_exon_variant | 0.95 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474794 | n.1137C>A | non_coding_transcript_exon_variant | 0.95 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474812 | n.1155G>A | non_coding_transcript_exon_variant | 0.88 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474830 | n.1173A>G | non_coding_transcript_exon_variant | 0.92 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1475120 | n.1463G>T | non_coding_transcript_exon_variant | 1.0 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1475452 | n.1795C>A | non_coding_transcript_exon_variant | 1.0 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1475458 | n.1801C>T | non_coding_transcript_exon_variant | 1.0 | capreomycin | |
linezolid | ||||||
rrl | 1475460 | n.1803A>G | non_coding_transcript_exon_variant | 1.0 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1475659 | n.2002G>A | non_coding_transcript_exon_variant | 1.0 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1475753 | n.2096C>G | non_coding_transcript_exon_variant | 1.0 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1475762 | n.2105G>T | non_coding_transcript_exon_variant | 1.0 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1475763 | n.2106C>T | non_coding_transcript_exon_variant | 1.0 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1475764 | n.2107A>C | non_coding_transcript_exon_variant | 1.0 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1475765 | n.2108A>G | non_coding_transcript_exon_variant | 1.0 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1475775 | n.2118G>T | non_coding_transcript_exon_variant | 1.0 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1475916 | n.2259C>T | non_coding_transcript_exon_variant | 1.0 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1475975 | n.2318C>T | non_coding_transcript_exon_variant | 1.0 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1475977 | n.2320A>G | non_coding_transcript_exon_variant | 1.0 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1475995 | n.2338G>A | non_coding_transcript_exon_variant | 1.0 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1475997 | n.2340A>G | non_coding_transcript_exon_variant | 1.0 | capreomycin | |
linezolid | ||||||
rrl | 1476086 | n.2429G>A | non_coding_transcript_exon_variant | 1.0 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476088 | n.2431A>C | non_coding_transcript_exon_variant | 1.0 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476095 | n.2438C>T | non_coding_transcript_exon_variant | 1.0 | capreomycin | |
linezolid | ||||||
rrl | 1476103 | n.2446C>A | non_coding_transcript_exon_variant | 1.0 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1476108 | n.2451T>G | non_coding_transcript_exon_variant | 1.0 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1476110 | n.2453G>T | non_coding_transcript_exon_variant | 1.0 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476115 | n.2458T>C | non_coding_transcript_exon_variant | 1.0 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476131 | n.2474C>T | non_coding_transcript_exon_variant | 1.0 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476214 | n.2557G>T | non_coding_transcript_exon_variant | 1.0 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476215 | n.2558C>T | non_coding_transcript_exon_variant | 1.0 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476224 | n.2567A>G | non_coding_transcript_exon_variant | 0.95 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476245 | n.2588C>T | non_coding_transcript_exon_variant | 0.95 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476246 | n.2589G>A | non_coding_transcript_exon_variant | 0.95 | capreomycin | |
linezolid | ||||||
rrl | 1476252 | n.2595T>G | non_coding_transcript_exon_variant | 0.91 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476256 | n.2599A>C | non_coding_transcript_exon_variant | 0.91 | capreomycin | |
linezolid | ||||||
rrl | 1476262 | n.2605G>A | non_coding_transcript_exon_variant | 0.91 | capreomycin | |
linezolid | ||||||
rrl | 1476281 | n.2624T>C | non_coding_transcript_exon_variant | 0.92 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476529 | n.2872A>T | non_coding_transcript_exon_variant | 1.0 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1476583 | n.2926G>A | non_coding_transcript_exon_variant | 0.95 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1476584 | n.2927C>T | non_coding_transcript_exon_variant | 0.95 | capreomycin | Not assoc w R |
linezolid | Uncertain significance | |||||
rrl | 1476594 | n.2937C>T | non_coding_transcript_exon_variant | 0.95 | capreomycin | Not assoc w R |
linezolid | Uncertain significance | |||||
rrl | 1476597 | n.2940G>A | non_coding_transcript_exon_variant | 0.94 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1476603 | n.2946G>A | non_coding_transcript_exon_variant | 0.94 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476608 | n.2951C>G | non_coding_transcript_exon_variant | 1.0 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476616 | n.2959A>G | non_coding_transcript_exon_variant | 1.0 | capreomycin | |
linezolid | ||||||
rrl | 1476628 | n.2971T>A | non_coding_transcript_exon_variant | 1.0 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rpsA | 1833778 | c.237C>G | synonymous_variant | 1.0 | pyrazinamide | |
rpsA | 1833835 | c.294C>T | synonymous_variant | 1.0 | pyrazinamide | |
rpsA | 1834303 | c.762T>G | synonymous_variant | 0.9 | pyrazinamide | |
rpsA | 1834306 | c.765T>C | synonymous_variant | 0.91 | pyrazinamide | |
rpsA | 1834411 | c.870T>C | synonymous_variant | 0.8 | pyrazinamide | |
rpsA | 1834417 | c.876G>C | synonymous_variant | 0.8 | pyrazinamide | |
rpsA | 1834451 | c.910T>C | synonymous_variant | 0.82 | pyrazinamide | |
rpsA | 1834456 | c.915T>G | synonymous_variant | 0.8 | pyrazinamide | |
rpsA | 1834468 | c.927A>G | synonymous_variant | 0.9 | pyrazinamide | |
rpsA | 1834489 | c.948T>C | synonymous_variant | 0.9 | pyrazinamide | |
rpsA | 1834522 | c.981C>T | synonymous_variant | 0.82 | pyrazinamide | |
rpsA | 1834527 | p.Arg329Gln | missense_variant | 0.8 | pyrazinamide | |
rpsA | 1834546 | c.1005T>C | synonymous_variant | 0.8 | pyrazinamide | |
rpsA | 1834633 | c.1092A>G | synonymous_variant | 0.92 | pyrazinamide | |
rpsA | 1834639 | c.1098T>C | synonymous_variant | 0.92 | pyrazinamide | |
rpsA | 1834666 | c.1125G>C | synonymous_variant | 1.0 | pyrazinamide | |
rpsA | 1834667 | p.Ala376Ser | missense_variant | 1.0 | pyrazinamide | |
rpsA | 1834690 | c.1149T>C | synonymous_variant | 1.0 | pyrazinamide | |
rpsA | 1834732 | c.1191T>C | synonymous_variant | 1.0 | pyrazinamide | |
kasA | 2518627 | c.513T>C | synonymous_variant | 1.0 | isoniazid | |
kasA | 2518636 | c.522C>A | synonymous_variant | 1.0 | isoniazid | |
kasA | 2518639 | c.525G>C | synonymous_variant | 1.0 | isoniazid | |
kasA | 2518645 | c.531G>C | synonymous_variant | 1.0 | isoniazid | |
kasA | 2518651 | c.537C>G | synonymous_variant | 1.0 | isoniazid | |
kasA | 2518678 | c.564C>T | synonymous_variant | 0.92 | isoniazid | |
kasA | 2518684 | c.570C>G | synonymous_variant | 0.92 | isoniazid | |
kasA | 2518688 | p.Val192Phe | missense_variant | 0.92 | isoniazid | |
kasA | 2518693 | c.579C>G | synonymous_variant | 0.92 | isoniazid | |
kasA | 2518714 | c.600A>C | synonymous_variant | 0.91 | isoniazid | |
kasA | 2518715 | p.Pro201Gly | missense_variant | 0.91 | isoniazid | |
kasA | 2518732 | c.618C>G | synonymous_variant | 0.92 | isoniazid | |
kasA | 2518739 | p.Ala209Thr | missense_variant | 0.93 | isoniazid | |
kasA | 2518747 | c.633C>G | synonymous_variant | 0.93 | isoniazid | |
kasA | 2518756 | c.642G>C | synonymous_variant | 0.9 | isoniazid | |
kasA | 2518759 | c.645C>G | synonymous_variant | 0.91 | isoniazid | |
kasA | 2518780 | p.Glu222Asp | missense_variant | 0.92 | isoniazid | |
kasA | 2518783 | c.669T>C | synonymous_variant | 0.92 | isoniazid | |
kasA | 2518787 | c.673_675delCGGinsGT | frameshift_variant&missense_variant | 0.92 | isoniazid | |
kasA | 2518792 | c.678C>G | synonymous_variant | 0.92 | isoniazid | |
kasA | 2518795 | c.681C>G | synonymous_variant | 0.92 | isoniazid | |
mtrB | 3625729 | c.885A>G | synonymous_variant | 0.93 | bedaquiline | |
rifampicin | Not assoc w R - Interim | |||||
mtrB | 3625744 | c.870G>A | synonymous_variant | 0.92 | bedaquiline | |
rifampicin | Not assoc w R - Interim | |||||
mtrB | 3625747 | c.867G>C | synonymous_variant | 0.92 | bedaquiline | |
rifampicin | Not assoc w R - Interim | |||||
mtrB | 3625755 | p.Ala287Thr | missense_variant | 0.91 | bedaquiline | |
rifampicin | Uncertain significance | |||||
lpqB | 3625762 | c.-852A>C | upstream_gene_variant | 0.91 | bedaquiline | |
rifampicin | ||||||
mtrB | 3625765 | c.849C>G | synonymous_variant | 0.91 | bedaquiline | |
rifampicin | Not assoc w R - Interim | |||||
lpqB | 3625795 | c.-885G>C | upstream_gene_variant | 0.92 | bedaquiline | |
rifampicin | ||||||
lpqB | 3625801 | c.-891G>C | upstream_gene_variant | 0.93 | bedaquiline | |
rifampicin | ||||||
mtrB | 3625806 | c.808A>C | synonymous_variant | 0.93 | bedaquiline | |
rifampicin | Not assoc w R - Interim | |||||
mtrB | 3625819 | c.795G>A | synonymous_variant | 0.94 | bedaquiline | |
rifampicin | Not assoc w R - Interim | |||||
lpqB | 3625828 | c.-918G>A | upstream_gene_variant | 0.94 | bedaquiline | |
rifampicin | ||||||
lpqB | 3625849 | c.-939T>C | upstream_gene_variant | 0.93 | bedaquiline | |
rifampicin | ||||||
mtrB | 3625852 | c.762A>G | synonymous_variant | 0.93 | bedaquiline | |
rifampicin | Not assoc w R - Interim | |||||
lpqB | 3625864 | c.-954T>G | upstream_gene_variant | 1.0 | bedaquiline | |
rifampicin | ||||||
rpoA | 3877875 | c.633T>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
rpoA | 3877881 | c.627G>C | synonymous_variant | 1.0 | rifampicin | |
rpoA | 3877893 | c.615C>G | synonymous_variant | 1.0 | rifampicin | |
clpC1 | 4039319 | c.1386T>C | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4039322 | c.1383T>C | synonymous_variant | 1.0 | pyrazinamide | |
clpC1 | 4039328 | c.1377A>G | synonymous_variant | 1.0 | pyrazinamide | |
clpC1 | 4039334 | c.1371G>C | synonymous_variant | 1.0 | pyrazinamide | |
clpC1 | 4039338 | p.Thr456Gln | missense_variant | 1.0 | pyrazinamide | |
clpC1 | 4039352 | c.1353C>G | synonymous_variant | 1.0 | pyrazinamide | |
clpC1 | 4039382 | c.1323C>G | synonymous_variant | 1.0 | pyrazinamide | |
clpC1 | 4039391 | c.1314T>G | synonymous_variant | 1.0 | pyrazinamide | |
clpC1 | 4039409 | c.1296T>C | synonymous_variant | 1.0 | pyrazinamide | |
clpC1 | 4039415 | p.Glu430Asp | missense_variant | 1.0 | pyrazinamide | Uncertain significance |
clpC1 | 4039430 | c.1275T>C | synonymous_variant | 1.0 | pyrazinamide | |
clpC1 | 4039442 | c.1263A>G | synonymous_variant | 1.0 | pyrazinamide | |
clpC1 | 4039610 | c.1095G>C | synonymous_variant | 1.0 | pyrazinamide | |
clpC1 | 4039649 | c.1056G>C | synonymous_variant | 1.0 | pyrazinamide | |
clpC1 | 4039652 | c.1053G>C | synonymous_variant | 1.0 | pyrazinamide | |
clpC1 | 4039655 | c.1050G>C | synonymous_variant | 1.0 | pyrazinamide | |
clpC1 | 4039664 | c.1041G>C | synonymous_variant | 1.0 | pyrazinamide | |
clpC1 | 4040423 | c.282A>G | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
embB | 4247566 | c.1053C>G | synonymous_variant | 0.9 | ethambutol | |
embB | 4247572 | c.1059A>G | synonymous_variant | 0.9 | ethambutol | |
embB | 4247576 | c.1063C>T | synonymous_variant | 0.9 | ethambutol |