TB-Profiler result

Run: SRR14334194
Summary

Run ID: SRR14334194

Sample name:

Date: 03-04-2023 10:34:04

Number of reads: 2671659

Percentage reads mapped: 41.82

Strain: lineage2.2.1

Drug-resistance: Pre-XDR-TB

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage2 East-Asian Beijing RD105 0.99
lineage2.2 East-Asian (Beijing) Beijing-RD207 RD105;RD207 1.0
lineage2.2.1 East-Asian (Beijing) Beijing-RD181 RD105;RD207;RD181 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
gyrA 7570 p.Ala90Val missense_variant 1.0 ofloxacin, moxifloxacin, levofloxacin, fluoroquinolones, ciprofloxacin
gyrA 7572 p.Ser91Pro missense_variant 1.0 ofloxacin, moxifloxacin, levofloxacin, fluoroquinolones, ciprofloxacin
rpoB 761155 p.Ser450Leu missense_variant 1.0 rifampicin
rpsL 781687 p.Lys43Arg missense_variant 1.0 streptomycin
rrs 1472644 n.799C>T non_coding_transcript_exon_variant 0.46 streptomycin
rrs 1472733 n.888G>A non_coding_transcript_exon_variant 0.3 streptomycin
rrs 1473247 n.1402C>A non_coding_transcript_exon_variant 0.27 kanamycin, capreomycin, aminoglycosides, amikacin
katG 2154987 c.1124dupC frameshift_variant 0.15 isoniazid
katG 2155168 p.Ser315Thr missense_variant 1.0 isoniazid
pncA 2289207 p.Asp12Gly missense_variant 0.97 pyrazinamide
embB 4248003 p.Gln497Arg missense_variant 1.0 ethambutol
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrB 5509 c.270C>A synonymous_variant 0.13
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7585 p.Ser95Thr missense_variant 1.0
gyrA 8576 c.1275C>A synonymous_variant 0.2
gyrA 8840 c.1539C>G synonymous_variant 0.12
gyrA 9304 p.Gly668Asp missense_variant 1.0
fgd1 491742 c.960T>C synonymous_variant 1.0
mshA 575213 c.-135G>C upstream_gene_variant 0.15
mshA 575494 c.147G>T synonymous_variant 0.25
mshA 575907 p.Ala187Val missense_variant 1.0
ccsA 620625 p.Ile245Met missense_variant 1.0
rpoB 760430 c.624T>C synonymous_variant 0.4
rpoB 760436 c.630C>G synonymous_variant 0.4
rpoB 760475 c.669A>G synonymous_variant 0.4
rpoB 760481 c.675G>C synonymous_variant 0.4
rpoB 760484 c.678A>G synonymous_variant 0.4
rpoB 760502 c.696C>G synonymous_variant 0.25
rpoB 760916 c.1110C>T synonymous_variant 0.14
rpoB 760946 c.1140A>G synonymous_variant 0.17
rpoB 760958 c.1152G>C synonymous_variant 0.17
rpoB 760960 p.Val385Ala missense_variant 0.12
rpoB 760965 p.Met387Leu missense_variant 0.2
rpoB 760970 c.1164G>C synonymous_variant 0.2
rpoB 760982 c.1176G>C synonymous_variant 0.14
rpoB 760985 c.1179G>C synonymous_variant 0.14
rpoB 760991 c.1185G>C synonymous_variant 0.18
rpoB 760997 c.1191G>C synonymous_variant 0.12
rpoB 761015 c.1209G>C synonymous_variant 0.25
rpoB 761027 c.1221A>C synonymous_variant 0.2
rpoB 761036 c.1230G>C synonymous_variant 0.2
rpoB 761037 c.1231T>C synonymous_variant 0.2
rpoB 762181 p.Asp792Ala missense_variant 0.12
rpoB 762185 c.2379_2380insC frameshift_variant 0.12
rpoB 762206 c.2400C>G synonymous_variant 0.12
rpoB 762209 c.2403C>G synonymous_variant 0.24
rpoB 762218 c.2412T>C synonymous_variant 0.27
rpoB 762233 c.2427G>C synonymous_variant 0.15
rpoB 762236 c.2430G>C synonymous_variant 0.15
rpoB 762251 c.2445G>C synonymous_variant 0.18
rpoB 762254 c.2448T>C synonymous_variant 0.18
rpoB 762257 c.2451C>G synonymous_variant 0.15
rpoB 762266 c.2460T>C synonymous_variant 0.22
rpoC 762857 c.-513C>G upstream_gene_variant 0.14
rpoB 762878 p.Ile1024Met missense_variant 0.13
rpoB 762879 p.Met1025Leu missense_variant 0.17
rpoC 763031 c.-339T>C upstream_gene_variant 0.95
rpoB 763083 p.Arg1093Ser missense_variant 0.23
rpoC 763483 c.114G>C synonymous_variant 0.24
rpoC 763486 c.117T>G synonymous_variant 0.24
rpoC 763507 c.138G>C synonymous_variant 0.14
rpoC 763528 c.159G>C synonymous_variant 0.18
rpoC 763531 c.162G>C synonymous_variant 0.12
rpoC 763534 c.165T>C synonymous_variant 0.24
rpoC 763537 c.168C>G synonymous_variant 0.22
rpoC 763546 c.177A>G synonymous_variant 0.29
rpoC 763550 p.Tyr61Ala missense_variant 0.14
rpoC 763570 c.201G>C synonymous_variant 0.23
rpoC 763573 c.204G>C synonymous_variant 0.17
rpoC 763622 p.Ala85Ser missense_variant 0.27
rpoC 763627 p.Lys86Asn missense_variant 0.18
rpoC 763633 c.264T>C synonymous_variant 0.22
rpoC 763636 c.267T>C synonymous_variant 0.19
rpoC 763642 c.273G>C synonymous_variant 0.25
rpoC 763669 c.300C>G synonymous_variant 0.22
rpoC 763696 c.327T>C synonymous_variant 0.14
rpoC 763708 c.339G>C synonymous_variant 0.14
rpoC 763714 c.345G>C synonymous_variant 0.12
rpoC 763717 c.348T>C synonymous_variant 0.13
rpoC 763732 c.363C>G synonymous_variant 0.14
rpoC 763926 p.Ala186Val missense_variant 0.22
rpoC 764308 c.939G>C synonymous_variant 0.18
rpoC 764365 c.996C>T synonymous_variant 0.14
rpoC 764380 c.1011G>C synonymous_variant 0.15
rpoC 764387 c.1018T>C synonymous_variant 0.17
rpoC 764461 c.1092A>G synonymous_variant 0.12
rpoC 764497 c.1128A>G synonymous_variant 0.2
rpoC 764498 p.Ser377Ala missense_variant 0.21
rpoC 764503 c.1134G>C synonymous_variant 0.21
rpoC 764507 p.Ala380Ser missense_variant 0.21
rpoC 764521 c.1152T>C synonymous_variant 0.35
rpoC 764536 c.1167G>C synonymous_variant 0.2
rpoC 764539 c.1170C>G synonymous_variant 0.32
rpoC 764548 c.1179G>C synonymous_variant 0.29
rpoC 764560 c.1191T>C synonymous_variant 0.16
rpoC 764566 c.1197C>G synonymous_variant 0.21
rpoC 764575 c.1206T>G synonymous_variant 0.21
rpoC 764581 c.1212T>C synonymous_variant 0.38
rpoC 764582 p.Leu405Met missense_variant 0.29
rpoC 764605 c.1236G>C synonymous_variant 0.16
rpoC 764611 c.1242G>T synonymous_variant 0.23
rpoC 764623 c.1254C>G synonymous_variant 0.19
rpoC 764632 c.1263T>C synonymous_variant 0.23
rpoC 764635 c.1266C>G synonymous_variant 0.14
rpoC 764644 c.1275G>C synonymous_variant 0.26
rpoC 764650 c.1281G>T synonymous_variant 0.21
rpoC 764695 c.1326T>C synonymous_variant 0.13
rpoC 764706 p.Leu446Gln missense_variant 0.23
rpoC 764749 c.1380G>C synonymous_variant 0.17
rpoC 764764 c.1395T>C synonymous_variant 0.19
rpoC 764780 c.1411_1412delAGinsTC synonymous_variant 0.15
rpoC 764858 c.1489T>C synonymous_variant 0.15
rpoC 764916 p.Leu516Pro missense_variant 0.91
rpoC 765350 p.Ala661Ser missense_variant 0.29
rpoC 766218 p.Asp950Gly missense_variant 0.13
rpoC 766636 p.Phe1089Leu missense_variant 0.25
rpoC 766661 p.Val1098Leu missense_variant 0.27
rpoC 766690 c.3321G>T synonymous_variant 0.17
mmpL5 775639 p.Ile948Val missense_variant 1.0
mmpL5 776100 p.Thr794Ile missense_variant 1.0
mmpL5 776182 p.Asp767Asn missense_variant 1.0
mmpL5 777103 p.Ala460Ser missense_variant 0.17
mmpL5 777851 c.630C>A synonymous_variant 0.17
mmpS5 779615 c.-710C>G upstream_gene_variant 1.0
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
fbiC 1304359 c.1429_1431delCGCinsAGA synonymous_variant 0.25
fbiC 1304908 p.Gly660Trp missense_variant 0.21
Rv1258c 1406760 c.580_581insC frameshift_variant 1.0
embR 1416968 p.Ala127Asp missense_variant 0.14
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrs 1472106 n.261G>A non_coding_transcript_exon_variant 0.26
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.27
rrs 1472123 n.278A>T non_coding_transcript_exon_variant 0.21
rrs 1472150 n.305T>A non_coding_transcript_exon_variant 0.36
rrs 1472151 n.306C>A non_coding_transcript_exon_variant 0.33
rrs 1472160 n.315C>T non_coding_transcript_exon_variant 0.2
rrs 1472172 n.327T>C non_coding_transcript_exon_variant 0.5
rrs 1472177 n.332C>T non_coding_transcript_exon_variant 0.18
rrs 1472203 n.358G>A non_coding_transcript_exon_variant 0.2
rrs 1472210 n.365A>C non_coding_transcript_exon_variant 0.17
rrs 1472214 n.369C>G non_coding_transcript_exon_variant 0.13
rrs 1472215 n.370A>G non_coding_transcript_exon_variant 0.15
rrs 1472234 n.389T>C non_coding_transcript_exon_variant 0.12
rrs 1472240 n.395G>A non_coding_transcript_exon_variant 0.16
rrs 1472251 n.406G>A non_coding_transcript_exon_variant 0.31
rrs 1472259 n.414C>A non_coding_transcript_exon_variant 0.15
rrs 1472286 n.441C>G non_coding_transcript_exon_variant 0.13
rrs 1472289 n.444T>G non_coding_transcript_exon_variant 0.24
rrs 1472290 n.445C>G non_coding_transcript_exon_variant 0.23
rrs 1472324 n.479G>C non_coding_transcript_exon_variant 0.25
rrs 1472325 n.480G>C non_coding_transcript_exon_variant 0.25
rrs 1472328 n.483G>C non_coding_transcript_exon_variant 0.17
rrs 1472344 n.499C>T non_coding_transcript_exon_variant 0.45
rrs 1472382 n.537G>A non_coding_transcript_exon_variant 0.21
rrs 1472389 n.544G>A non_coding_transcript_exon_variant 0.2
rrs 1472400 n.555C>T non_coding_transcript_exon_variant 0.19
rrs 1472435 n.590T>C non_coding_transcript_exon_variant 0.16
rrs 1472439 n.594C>T non_coding_transcript_exon_variant 0.16
rrs 1472448 n.603T>C non_coding_transcript_exon_variant 0.14
rrs 1472450 n.605A>G non_coding_transcript_exon_variant 0.14
rrs 1472462 n.617T>C non_coding_transcript_exon_variant 0.14
rrs 1472464 n.619A>G non_coding_transcript_exon_variant 0.21
rrs 1472471 n.626G>A non_coding_transcript_exon_variant 0.16
rrs 1472489 n.644A>T non_coding_transcript_exon_variant 0.15
rrs 1472494 n.649A>G non_coding_transcript_exon_variant 0.13
rrs 1472498 n.653C>T non_coding_transcript_exon_variant 0.36
rrs 1472530 n.685G>A non_coding_transcript_exon_variant 0.29
rrs 1472558 n.713G>A non_coding_transcript_exon_variant 0.45
rrs 1472569 n.724G>A non_coding_transcript_exon_variant 0.42
rrs 1472573 n.728C>T non_coding_transcript_exon_variant 0.17
rrs 1472581 n.736A>T non_coding_transcript_exon_variant 0.25
rrs 1472584 n.739A>T non_coding_transcript_exon_variant 0.24
rrs 1472596 n.751G>T non_coding_transcript_exon_variant 0.14
rrs 1472598 n.753A>T non_coding_transcript_exon_variant 0.15
rrs 1472607 n.762G>A non_coding_transcript_exon_variant 0.44
rrs 1472612 n.767G>T non_coding_transcript_exon_variant 0.27
rrs 1472614 n.769G>T non_coding_transcript_exon_variant 0.15
rrs 1472616 n.771G>A non_coding_transcript_exon_variant 0.18
rrs 1472655 n.810G>T non_coding_transcript_exon_variant 0.2
rrs 1472660 n.815T>C non_coding_transcript_exon_variant 0.48
rrs 1472661 n.816A>G non_coding_transcript_exon_variant 0.44
rrs 1472697 n.852T>C non_coding_transcript_exon_variant 0.17
rrs 1472713 n.868T>C non_coding_transcript_exon_variant 0.59
rrs 1472714 n.869A>G non_coding_transcript_exon_variant 0.48
rrs 1472716 n.871C>T non_coding_transcript_exon_variant 0.25
rrs 1472742 n.897C>T non_coding_transcript_exon_variant 0.33
rrs 1472744 n.899A>G non_coding_transcript_exon_variant 0.37
rrs 1472767 n.922G>A non_coding_transcript_exon_variant 0.36
rrs 1472781 n.936C>T non_coding_transcript_exon_variant 0.43
rrs 1472793 n.948A>T non_coding_transcript_exon_variant 0.4
rrs 1472803 n.958T>A non_coding_transcript_exon_variant 0.19
rrs 1472828 n.983T>C non_coding_transcript_exon_variant 0.41
rrs 1472874 n.1029C>T non_coding_transcript_exon_variant 0.18
rrs 1472875 n.1030T>G non_coding_transcript_exon_variant 0.15
rrs 1472880 n.1035G>A non_coding_transcript_exon_variant 0.3
rrs 1472895 n.1050C>T non_coding_transcript_exon_variant 0.46
rrs 1472952 n.1107T>C non_coding_transcript_exon_variant 0.23
rrs 1472955 n.1110C>T non_coding_transcript_exon_variant 0.25
rrs 1472956 n.1111T>C non_coding_transcript_exon_variant 0.37
rrs 1472957 n.1112C>T non_coding_transcript_exon_variant 0.51
rrs 1472973 n.1128A>G non_coding_transcript_exon_variant 0.23
rrs 1472974 n.1129A>T non_coding_transcript_exon_variant 0.16
rrs 1472977 n.1133dupT non_coding_transcript_exon_variant 0.15
rrs 1472987 n.1142G>A non_coding_transcript_exon_variant 0.53
rrs 1472989 n.1144G>A non_coding_transcript_exon_variant 0.15
rrs 1472990 n.1145A>G non_coding_transcript_exon_variant 0.32
rrs 1473005 n.1160C>T non_coding_transcript_exon_variant 0.19
rrs 1473009 n.1164T>C non_coding_transcript_exon_variant 0.14
rrs 1473026 n.1181T>C non_coding_transcript_exon_variant 0.15
rrs 1473035 n.1190G>A non_coding_transcript_exon_variant 0.4
rrs 1473055 n.1210C>T non_coding_transcript_exon_variant 0.15
rrs 1473056 n.1211A>T non_coding_transcript_exon_variant 0.22
rrs 1473066 n.1221A>G non_coding_transcript_exon_variant 0.18
rrs 1473080 n.1235C>T non_coding_transcript_exon_variant 0.32
rrs 1473088 n.1243A>G non_coding_transcript_exon_variant 0.19
rrs 1473089 n.1244A>C non_coding_transcript_exon_variant 0.15
rrs 1473093 n.1248C>T non_coding_transcript_exon_variant 0.19
rrs 1473099 n.1254T>C non_coding_transcript_exon_variant 0.12
rrs 1473100 n.1255G>A non_coding_transcript_exon_variant 0.32
rrs 1473102 n.1257C>T non_coding_transcript_exon_variant 0.23
rrs 1473104 n.1259C>T non_coding_transcript_exon_variant 0.35
rrs 1473110 n.1265T>G non_coding_transcript_exon_variant 0.32
rrs 1473111 n.1266A>G non_coding_transcript_exon_variant 0.36
rrs 1473115 n.1270G>T non_coding_transcript_exon_variant 0.15
rrs 1473121 n.1276T>C non_coding_transcript_exon_variant 0.28
rrs 1473123 n.1278A>G non_coding_transcript_exon_variant 0.16
rrs 1473132 n.1287T>C non_coding_transcript_exon_variant 0.15
rrs 1473135 n.1290C>T non_coding_transcript_exon_variant 0.19
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.56
rrs 1473148 n.1303G>A non_coding_transcript_exon_variant 0.19
rrs 1473163 n.1318C>T non_coding_transcript_exon_variant 0.27
rrs 1473164 n.1319C>A non_coding_transcript_exon_variant 0.15
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.64
rrs 1473177 n.1332G>A non_coding_transcript_exon_variant 0.21
rrs 1473206 n.1361G>A non_coding_transcript_exon_variant 0.18
rrs 1473226 n.1381C>T non_coding_transcript_exon_variant 0.2
rrs 1473252 n.1407T>C non_coding_transcript_exon_variant 0.42
rrs 1473259 n.1414C>T non_coding_transcript_exon_variant 0.46
rrs 1473276 n.1431A>G non_coding_transcript_exon_variant 0.32
rrs 1473283 n.1438T>C non_coding_transcript_exon_variant 0.26
rrs 1473301 n.1456T>C non_coding_transcript_exon_variant 0.25
rrs 1473315 n.1470T>C non_coding_transcript_exon_variant 0.12
rrl 1474124 n.467G>C non_coding_transcript_exon_variant 0.25
rrl 1474125 n.468C>G non_coding_transcript_exon_variant 0.25
rrl 1474135 n.478G>A non_coding_transcript_exon_variant 0.18
rrl 1474140 n.483C>T non_coding_transcript_exon_variant 0.37
rrl 1474141 n.484G>C non_coding_transcript_exon_variant 0.2
rrl 1474142 n.485C>G non_coding_transcript_exon_variant 0.21
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.44
rrl 1474155 n.498G>A non_coding_transcript_exon_variant 0.26
rrl 1474164 n.507C>T non_coding_transcript_exon_variant 0.31
rrl 1474174 n.517A>G non_coding_transcript_exon_variant 0.22
rrl 1474181 n.524C>T non_coding_transcript_exon_variant 0.27
rrl 1474183 n.526T>C non_coding_transcript_exon_variant 0.35
rrl 1474184 n.527C>T non_coding_transcript_exon_variant 0.39
rrl 1474202 n.545T>C non_coding_transcript_exon_variant 0.26
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 0.39
rrl 1474253 n.596A>T non_coding_transcript_exon_variant 0.24
rrl 1474263 n.606G>A non_coding_transcript_exon_variant 0.35
rrl 1474269 n.612C>T non_coding_transcript_exon_variant 0.32
rrl 1474348 n.691C>T non_coding_transcript_exon_variant 0.19
rrl 1474351 n.694G>C non_coding_transcript_exon_variant 0.32
rrl 1474353 n.696A>G non_coding_transcript_exon_variant 0.33
rrl 1474362 n.705A>G non_coding_transcript_exon_variant 0.29
rrl 1474384 n.727C>T non_coding_transcript_exon_variant 0.18
rrl 1474387 n.730C>T non_coding_transcript_exon_variant 0.3
rrl 1474402 n.745T>C non_coding_transcript_exon_variant 0.14
rrl 1474467 n.810A>G non_coding_transcript_exon_variant 0.16
rrl 1474488 n.831G>T non_coding_transcript_exon_variant 0.21
rrl 1474497 n.840G>C non_coding_transcript_exon_variant 0.23
rrl 1474498 n.841G>T non_coding_transcript_exon_variant 0.15
rrl 1474505 n.848C>G non_coding_transcript_exon_variant 0.15
rrl 1474506 n.849C>G non_coding_transcript_exon_variant 0.22
rrl 1474516 n.859C>A non_coding_transcript_exon_variant 0.33
rrl 1474527 n.870T>C non_coding_transcript_exon_variant 0.13
rrl 1474529 n.872A>C non_coding_transcript_exon_variant 0.2
rrl 1474537 n.880G>A non_coding_transcript_exon_variant 0.49
rrl 1474540 n.883T>G non_coding_transcript_exon_variant 0.15
rrl 1474551 n.894G>C non_coding_transcript_exon_variant 0.14
rrl 1474558 n.901G>A non_coding_transcript_exon_variant 0.15
rrl 1474626 n.969T>C non_coding_transcript_exon_variant 0.26
rrl 1474632 n.975G>T non_coding_transcript_exon_variant 0.35
rrl 1474636 n.979A>T non_coding_transcript_exon_variant 0.33
rrl 1474637 n.980C>T non_coding_transcript_exon_variant 0.33
rrl 1474639 n.982G>C non_coding_transcript_exon_variant 0.33
rrl 1474663 n.1006C>T non_coding_transcript_exon_variant 0.15
rrl 1474676 n.1019T>A non_coding_transcript_exon_variant 0.23
rrl 1474692 n.1035G>A non_coding_transcript_exon_variant 0.25
rrl 1474734 n.1077G>T non_coding_transcript_exon_variant 0.3
rrl 1474736 n.1079C>T non_coding_transcript_exon_variant 0.19
rrl 1474749 n.1092C>T non_coding_transcript_exon_variant 0.32
rrl 1474751 n.1094G>A non_coding_transcript_exon_variant 0.26
rrl 1474753 n.1097delC non_coding_transcript_exon_variant 0.43
rrl 1474760 n.1103A>G non_coding_transcript_exon_variant 0.42
rrl 1474777 n.1120T>C non_coding_transcript_exon_variant 0.17
rrl 1474779 n.1122G>A non_coding_transcript_exon_variant 0.23
rrl 1474782 n.1125G>A non_coding_transcript_exon_variant 0.14
rrl 1474783 n.1126G>A non_coding_transcript_exon_variant 0.17
rrl 1474784 n.1127C>T non_coding_transcript_exon_variant 0.32
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.65
rrl 1474798 n.1141C>G non_coding_transcript_exon_variant 0.32
rrl 1474803 n.1146G>A non_coding_transcript_exon_variant 0.18
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.31
rrl 1474823 n.1166C>G non_coding_transcript_exon_variant 0.49
rrl 1474824 n.1167A>G non_coding_transcript_exon_variant 0.2
rrl 1474825 n.1168G>A non_coding_transcript_exon_variant 0.27
rrl 1474827 n.1170C>T non_coding_transcript_exon_variant 0.2
rrl 1474830 n.1173A>G non_coding_transcript_exon_variant 0.31
rrl 1474837 n.1180A>G non_coding_transcript_exon_variant 0.26
rrl 1474844 n.1187G>T non_coding_transcript_exon_variant 0.17
rrl 1474864 n.1207C>T non_coding_transcript_exon_variant 0.43
rrl 1474866 n.1209C>A non_coding_transcript_exon_variant 0.25
rrl 1474869 n.1212G>T non_coding_transcript_exon_variant 0.36
rrl 1474892 n.1235G>A non_coding_transcript_exon_variant 0.35
rrl 1474896 n.1239A>G non_coding_transcript_exon_variant 0.6
rrl 1474901 n.1244A>G non_coding_transcript_exon_variant 0.26
rrl 1474902 n.1245T>C non_coding_transcript_exon_variant 0.34
rrl 1474903 n.1246T>A non_coding_transcript_exon_variant 0.31
rrl 1474904 n.1247G>C non_coding_transcript_exon_variant 0.66
rrl 1474905 n.1248T>C non_coding_transcript_exon_variant 0.33
rrl 1474913 n.1256T>A non_coding_transcript_exon_variant 0.64
rrl 1474913 n.1256T>C non_coding_transcript_exon_variant 0.68
rrl 1474918 n.1261T>C non_coding_transcript_exon_variant 0.13
rrl 1474920 n.1263G>C non_coding_transcript_exon_variant 0.38
rrl 1474921 n.1264C>T non_coding_transcript_exon_variant 0.3
rrl 1474932 n.1275C>T non_coding_transcript_exon_variant 0.4
rrl 1474938 n.1281G>A non_coding_transcript_exon_variant 0.25
rrl 1475060 n.1404delC non_coding_transcript_exon_variant 0.16
rrl 1475063 n.1406A>T non_coding_transcript_exon_variant 0.16
rrl 1475076 n.1419C>T non_coding_transcript_exon_variant 0.15
rrl 1475088 n.1431A>G non_coding_transcript_exon_variant 0.14
rrl 1475090 n.1433A>T non_coding_transcript_exon_variant 0.14
rrl 1475108 n.1451C>T non_coding_transcript_exon_variant 0.2
rrl 1475110 n.1454_1457delGGCC non_coding_transcript_exon_variant 0.25
rrl 1475118 n.1461C>T non_coding_transcript_exon_variant 0.19
rrl 1475120 n.1463_1464insTCTC non_coding_transcript_exon_variant 0.21
rrl 1475129 n.1472G>T non_coding_transcript_exon_variant 0.22
rrl 1475137 n.1480A>T non_coding_transcript_exon_variant 0.16
rrl 1475170 n.1513A>T non_coding_transcript_exon_variant 0.25
rrl 1475190 n.1533T>A non_coding_transcript_exon_variant 0.2
rrl 1475197 n.1540G>A non_coding_transcript_exon_variant 0.25
rrl 1475224 n.1567T>C non_coding_transcript_exon_variant 0.18
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.18
rrl 1475531 n.1874C>T non_coding_transcript_exon_variant 0.17
rrl 1475539 n.1882A>T non_coding_transcript_exon_variant 0.17
rrl 1475545 n.1888T>G non_coding_transcript_exon_variant 0.15
rrl 1475550 n.1893A>C non_coding_transcript_exon_variant 0.14
rrl 1475552 n.1895G>C non_coding_transcript_exon_variant 0.14
rrl 1475672 n.2015C>T non_coding_transcript_exon_variant 0.14
rrl 1475673 n.2016T>C non_coding_transcript_exon_variant 0.15
rrl 1475696 n.2039T>A non_coding_transcript_exon_variant 0.15
rrl 1475699 n.2042C>T non_coding_transcript_exon_variant 0.29
rrl 1475703 n.2046A>T non_coding_transcript_exon_variant 0.15
rrl 1475704 n.2047C>T non_coding_transcript_exon_variant 0.18
rrl 1475713 n.2056C>G non_coding_transcript_exon_variant 0.16
rrl 1475716 n.2059A>G non_coding_transcript_exon_variant 0.14
rrl 1475722 n.2065G>T non_coding_transcript_exon_variant 0.29
rrl 1475753 n.2096C>T non_coding_transcript_exon_variant 0.25
rrl 1475756 n.2101_2108delACCCGCAA non_coding_transcript_exon_variant 0.32
rrl 1475766 n.2109G>C non_coding_transcript_exon_variant 0.18
rrl 1475769 n.2112T>C non_coding_transcript_exon_variant 0.31
rrl 1475775 n.2118G>T non_coding_transcript_exon_variant 0.14
rrl 1475803 n.2146T>C non_coding_transcript_exon_variant 0.17
rrl 1475804 n.2147G>C non_coding_transcript_exon_variant 0.17
rrl 1475816 n.2159C>G non_coding_transcript_exon_variant 0.21
rrl 1475817 n.2160A>G non_coding_transcript_exon_variant 0.23
rrl 1475858 n.2201T>C non_coding_transcript_exon_variant 0.14
rrl 1475869 n.2212C>A non_coding_transcript_exon_variant 0.16
rrl 1475881 n.2224T>C non_coding_transcript_exon_variant 0.36
rrl 1475883 n.2226A>T non_coding_transcript_exon_variant 0.42
rrl 1475884 n.2227A>G non_coding_transcript_exon_variant 0.32
rrl 1475897 n.2240T>C non_coding_transcript_exon_variant 0.38
rrl 1475898 n.2241A>G non_coding_transcript_exon_variant 0.28
rrl 1475899 n.2242G>A non_coding_transcript_exon_variant 0.24
rrl 1475900 n.2243A>G non_coding_transcript_exon_variant 0.19
rrl 1475902 n.2245T>C non_coding_transcript_exon_variant 0.22
rrl 1475906 n.2249C>T non_coding_transcript_exon_variant 0.26
rrl 1475916 n.2259C>G non_coding_transcript_exon_variant 0.22
rrl 1475943 n.2286G>A non_coding_transcript_exon_variant 0.27
rrl 1475952 n.2295A>G non_coding_transcript_exon_variant 0.31
rrl 1475970 n.2313C>T non_coding_transcript_exon_variant 0.18
rrl 1475975 n.2318C>T non_coding_transcript_exon_variant 0.38
rrl 1475977 n.2320A>G non_coding_transcript_exon_variant 0.4
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.38
rrl 1475993 n.2336C>T non_coding_transcript_exon_variant 0.19
rrl 1475997 n.2340A>T non_coding_transcript_exon_variant 0.15
rrl 1476131 n.2474C>T non_coding_transcript_exon_variant 0.18
rrl 1476194 n.2537A>G non_coding_transcript_exon_variant 0.3
rrl 1476200 n.2543A>T non_coding_transcript_exon_variant 0.27
rrl 1476201 n.2544C>T non_coding_transcript_exon_variant 0.24
rrl 1476215 n.2558C>T non_coding_transcript_exon_variant 0.15
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.2
rrl 1476225 n.2568T>G non_coding_transcript_exon_variant 0.18
rrl 1476229 n.2572C>T non_coding_transcript_exon_variant 0.22
rrl 1476245 n.2588C>T non_coding_transcript_exon_variant 0.18
rrl 1476251 n.2594T>C non_coding_transcript_exon_variant 0.4
rrl 1476252 n.2595T>G non_coding_transcript_exon_variant 0.16
rrl 1476256 n.2599A>T non_coding_transcript_exon_variant 0.15
rrl 1476260 n.2603A>G non_coding_transcript_exon_variant 0.59
rrl 1476268 n.2611A>T non_coding_transcript_exon_variant 0.32
rrl 1476275 n.2618T>A non_coding_transcript_exon_variant 0.31
rrl 1476279 n.2622G>A non_coding_transcript_exon_variant 0.29
rrl 1476280 n.2623A>C non_coding_transcript_exon_variant 0.33
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.24
rrl 1476293 n.2636C>T non_coding_transcript_exon_variant 0.33
rrl 1476294 n.2637A>G non_coding_transcript_exon_variant 0.33
rrl 1476295 n.2638C>G non_coding_transcript_exon_variant 0.36
rrl 1476296 n.2639C>T non_coding_transcript_exon_variant 0.35
rrl 1476297 n.2640C>T non_coding_transcript_exon_variant 0.46
rrl 1476300 n.2643G>T non_coding_transcript_exon_variant 0.16
rrl 1476301 n.2644A>C non_coding_transcript_exon_variant 0.36
rrl 1476302 n.2645G>A non_coding_transcript_exon_variant 0.25
rrl 1476311 n.2654G>C non_coding_transcript_exon_variant 0.38
rrl 1476312 n.2655T>C non_coding_transcript_exon_variant 0.38
rrl 1476313 n.2656G>A non_coding_transcript_exon_variant 0.38
rrl 1476332 n.2675G>C non_coding_transcript_exon_variant 0.37
rrl 1476353 n.2696G>T non_coding_transcript_exon_variant 0.45
rrl 1476358 n.2701T>C non_coding_transcript_exon_variant 0.52
rrl 1476359 n.2702C>G non_coding_transcript_exon_variant 0.18
rrl 1476369 n.2712C>T non_coding_transcript_exon_variant 0.53
rrl 1476372 n.2715T>C non_coding_transcript_exon_variant 0.49
rrl 1476381 n.2724G>C non_coding_transcript_exon_variant 0.18
rrl 1476382 n.2725A>G non_coding_transcript_exon_variant 0.5
rrl 1476383 n.2726T>A non_coding_transcript_exon_variant 0.5
rrl 1476408 n.2751G>A non_coding_transcript_exon_variant 0.53
rrl 1476425 n.2768G>T non_coding_transcript_exon_variant 0.45
rrl 1476428 n.2771C>T non_coding_transcript_exon_variant 0.8
rrl 1476429 n.2772A>C non_coding_transcript_exon_variant 0.53
rrl 1476466 n.2809C>T non_coding_transcript_exon_variant 0.59
rrl 1476481 n.2824T>C non_coding_transcript_exon_variant 0.72
rrl 1476506 n.2849T>C non_coding_transcript_exon_variant 0.6
rrl 1476514 n.2857C>T non_coding_transcript_exon_variant 0.23
rrl 1476515 n.2858C>T non_coding_transcript_exon_variant 0.21
rrl 1476517 n.2860C>T non_coding_transcript_exon_variant 0.24
rrl 1476519 n.2862C>G non_coding_transcript_exon_variant 0.16
rrl 1476530 n.2873C>T non_coding_transcript_exon_variant 0.27
rrl 1476535 n.2878G>A non_coding_transcript_exon_variant 0.19
rrl 1476536 n.2879G>A non_coding_transcript_exon_variant 0.42
rrl 1476537 n.2880A>G non_coding_transcript_exon_variant 0.17
rrl 1476538 n.2881A>G non_coding_transcript_exon_variant 0.31
rrl 1476539 n.2882A>G non_coding_transcript_exon_variant 0.4
rrl 1476540 n.2883C>G non_coding_transcript_exon_variant 0.52
rrl 1476547 n.2890C>T non_coding_transcript_exon_variant 0.3
rrl 1476567 n.2910C>T non_coding_transcript_exon_variant 0.38
rrl 1476572 n.2915G>A non_coding_transcript_exon_variant 0.28
rrl 1476573 n.2916A>T non_coding_transcript_exon_variant 0.45
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.42
inhA 1674892 p.Asn231Asp missense_variant 1.0
rpsA 1833727 c.186G>C synonymous_variant 0.12
rpsA 1833829 c.288A>G synonymous_variant 0.13
rpsA 1833841 c.300C>G synonymous_variant 0.17
rpsA 1833847 c.306C>G synonymous_variant 0.16
rpsA 1833856 c.315A>G synonymous_variant 0.19
rpsA 1833928 c.387G>C synonymous_variant 0.12
rpsA 1833949 c.408T>C synonymous_variant 0.12
rpsA 1833979 c.438T>C synonymous_variant 0.12
rpsA 1834069 c.528G>C synonymous_variant 0.12
rpsA 1834177 c.636A>C synonymous_variant 1.0
rpsA 1834249 c.708T>C synonymous_variant 0.12
rpsA 1834489 c.948T>C synonymous_variant 0.14
rpsA 1834528 c.987T>C synonymous_variant 0.14
tlyA 1917972 c.33A>G synonymous_variant 1.0
ndh 2101990 c.1053G>T synonymous_variant 0.14
ndh 2102392 c.651C>A synonymous_variant 0.15
ndh 2102398 c.645C>T synonymous_variant 0.17
katG 2154724 p.Arg463Leu missense_variant 1.0
katG 2155051 p.Thr354Ile missense_variant 0.18
katG 2155389 c.723C>A synonymous_variant 0.18
katG 2155784 p.Ala110Ser missense_variant 0.22
katG 2155787 p.Ala109Thr missense_variant 0.22
katG 2155794 c.318G>A synonymous_variant 0.22
PPE35 2167814 c.2799C>T synonymous_variant 0.33
PPE35 2167865 c.2748G>C synonymous_variant 0.14
PPE35 2167868 c.2745A>C synonymous_variant 0.13
PPE35 2167926 p.Leu896Ser missense_variant 1.0
PPE35 2168255 c.2357delT frameshift_variant 0.17
PPE35 2170048 p.Leu189Val missense_variant 0.18
PPE35 2170053 p.Thr187Ser missense_variant 0.19
PPE35 2170147 p.Ser156Ala missense_variant 0.17
PPE35 2170351 p.Thr88Ala missense_variant 0.13
PPE35 2170372 p.Thr81Ala missense_variant 0.18
PPE35 2170385 c.228G>T synonymous_variant 0.15
PPE35 2170547 c.66A>C synonymous_variant 0.15
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
eis 2714131 p.Glu401Gly missense_variant 0.15
eis 2714136 c.1197G>T synonymous_variant 0.15
eis 2715005 p.Asp110Tyr missense_variant 0.15
eis 2715579 c.-247G>C upstream_gene_variant 0.33
folC 2746789 p.Ile270Met missense_variant 0.14
pepQ 2859877 p.Leu181Pro missense_variant 0.17
thyX 3068083 c.-138T>C upstream_gene_variant 0.12
thyX 3068091 c.-146T>G upstream_gene_variant 0.12
thyA 3074532 c.-61C>A upstream_gene_variant 0.15
ald 3086788 c.-32T>C upstream_gene_variant 1.0
fbiD 3339650 p.Leu178Pro missense_variant 0.14
Rv3083 3449209 p.Asp236Tyr missense_variant 0.22
Rv3083 3449753 p.Gly417Val missense_variant 0.16
fprA 3473996 c.-11_-10insA upstream_gene_variant 1.0
fprA 3474035 p.Gly10Val missense_variant 0.17
fprA 3474099 p.Asp31Glu missense_variant 0.22
fprA 3474243 c.237C>T synonymous_variant 0.15
Rv3236c 3612813 p.Thr102Ala missense_variant 1.0
rpoA 3878624 c.-117C>A upstream_gene_variant 0.33
ddn 3986653 c.-191G>C upstream_gene_variant 0.14
clpC1 4038173 p.Glu844Asp missense_variant 0.18
clpC1 4039178 c.1527G>C synonymous_variant 0.12
clpC1 4039714 p.Tyr331His missense_variant 0.12
clpC1 4039829 c.874_876delTTGinsCTC synonymous_variant 0.15
clpC1 4039838 c.867G>C synonymous_variant 0.15
clpC1 4039850 c.855T>C synonymous_variant 0.14
clpC1 4039929 p.Ser259Thr missense_variant 0.13
clpC1 4039934 c.771G>C synonymous_variant 0.13
clpC1 4039946 c.759A>C synonymous_variant 0.14
clpC1 4039952 c.753T>C synonymous_variant 0.14
clpC1 4039994 p.Glu237Asp missense_variant 0.21
clpC1 4040003 c.702G>C synonymous_variant 0.12
clpC1 4040024 c.681A>G synonymous_variant 0.16
embC 4240982 p.Ser374Gly missense_variant 0.12
embC 4242096 p.Ala745Asp missense_variant 0.2
embC 4242377 p.Leu839Met missense_variant 0.4
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embC 4242735 p.Ile958Thr missense_variant 0.12
embA 4243115 c.-118C>T upstream_gene_variant 0.14
embA 4243460 c.228C>T synonymous_variant 1.0
embA 4244845 c.1614dupC frameshift_variant 0.17
embA 4245739 p.Arg836His missense_variant 0.33
embB 4246544 p.Thr11Pro missense_variant 0.36
embB 4246548 p.Pro12Gln missense_variant 0.21
embB 4246555 c.42G>C synonymous_variant 0.27
embB 4246556 p.Ala15Pro missense_variant 0.27
embB 4246567 c.54_55insT frameshift_variant 0.31
embB 4246712 p.Val67Leu missense_variant 0.15
embB 4246897 c.384C>A synonymous_variant 0.2
embB 4247739 p.Ala409Glu missense_variant 0.15
embB 4249757 p.Thr1082Ala missense_variant 1.0
aftB 4267647 p.Asp397Gly missense_variant 1.0
aftB 4268623 p.Trp72Arg missense_variant 0.5
aftB 4268848 c.-12C>A upstream_gene_variant 0.15
ubiA 4269116 p.Arg240Cys missense_variant 1.0
ethA 4326125 p.Gly450Val missense_variant 0.18
ethA 4326405 p.Asp357Tyr missense_variant 1.0
ethA 4327275 p.Arg67Ser missense_variant 0.22
ethR 4328055 p.His169Gln missense_variant 0.13
ethA 4328458 c.-985C>T upstream_gene_variant 0.13
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
gid 4407588 c.615A>G synonymous_variant 1.0
gid 4407605 p.Ala200Thr missense_variant 0.13
gid 4407927 p.Glu92Asp missense_variant 1.0
gid 4408414 c.-212G>T upstream_gene_variant 0.18