TB-Profiler result

Run: SRR26399239
Summary

Run ID: SRR26399239

Sample name:

Date: 2024-04-14T01:51:16.026747

Number of reads: 121159

Percentage reads mapped: 59.78

Median coverage: 0.0

Strain: lineage4.9

Spoligotype:

Drug-resistance: Sensitive

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage4 Euro-American None 1.0
lineage4.9 Euro-American (H37Rv-like) None 0.97
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
gyrA 7406 c.105G>C synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 7415 c.114C>A synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 7418 c.117C>T synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 7421 c.120G>C synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 7442 c.141G>C synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 7448 c.147G>A synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 7451 c.150C>G synonymous_variant 0.97 levofloxacin
moxifloxacin
gyrA 7457 c.156T>C synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 7463 c.162G>C synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 7472 c.171T>C synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7475 c.174A>C synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 7480 p.Phe60Tyr missense_variant 1.0 levofloxacin
moxifloxacin
gyrA 7484 c.183T>C synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 7487 c.186C>G synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7490 c.189C>G synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 7496 c.195C>T synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 7499 c.198G>C synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 7506 p.Ser69Gly missense_variant 1.0 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 7517 c.216G>A synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 7523 c.222C>G synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7532 c.231T>C synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7569 p.Ala90Ser missense_variant 1.0 levofloxacin
moxifloxacin
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7587 c.286C>T synonymous_variant 0.95 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7601 c.300C>G synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7605 p.Pro102Ser missense_variant 1.0 levofloxacin
moxifloxacin
gyrA 7614 p.Leu105Met missense_variant 1.0 levofloxacin
moxifloxacin
gyrA 7631 c.330G>C synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 7637 c.336C>T synonymous_variant 0.94 levofloxacin
moxifloxacin
gyrA 7652 c.351C>G synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 7658 c.357A>G synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 7661 c.360C>T synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 7664 c.363T>C synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 7670 c.369A>G synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 7671 c.370_372delCCGinsGT frameshift_variant&missense_variant 1.0 levofloxacin
moxifloxacin
gyrA 7679 c.378G>C synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 7683 c.382A>C synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 7694 c.393A>G synonymous_variant 0.97 levofloxacin
moxifloxacin
gyrA 7697 c.396C>A synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 7706 c.405C>G synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 7710 c.409T>C synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 7728 c.427_429delAGGinsCC frameshift_variant&missense_variant 1.0 levofloxacin
moxifloxacin
gyrA 7748 c.447A>C synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 7763 c.462T>C synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7781 c.480G>C synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 7790 c.489G>C synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 7797 c.496_498delCTAinsTG frameshift_variant&stop_gained 1.0 levofloxacin
moxifloxacin
gyrA 7821 c.520C>T synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7832 c.531G>C synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 7835 c.534A>C synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 8930 c.1629C>G synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 8939 c.1638T>C synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 8945 c.1644G>T synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 8946 c.1645_1647delTTGinsCC frameshift_variant&missense_variant 1.0 levofloxacin
moxifloxacin
gyrA 8951 c.1650G>A synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 8967 p.Ala556Lys missense_variant 1.0 levofloxacin
moxifloxacin
gyrA 8981 c.1680G>C synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8996 c.1695T>C synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 8998 p.Leu566Trp missense_variant 1.0 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9023 c.1722A>C synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9029 c.1728T>G synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 9032 c.1731T>C synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 9035 c.1734G>C synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 9051 c.1750T>C synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 9056 c.1755C>G synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9068 c.1767G>C synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 9071 c.1770G>C synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 9074 c.1773G>C synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 9080 c.1779G>C synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 9099 c.1798_1800delTTAinsCG frameshift_variant&missense_variant 0.95 levofloxacin
moxifloxacin
gyrA 9113 c.1812C>G synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 9119 c.1818A>G synonymous_variant 1.0 levofloxacin
moxifloxacin
mshA 575864 c.517T>C synonymous_variant 0.96 ethionamide
isoniazid
mshA 575878 c.531A>C synonymous_variant 0.95 ethionamide
isoniazid
mshA 575884 c.537G>C synonymous_variant 0.94 ethionamide
isoniazid
mshA 575887 c.540G>C synonymous_variant 0.93 ethionamide
isoniazid
rpoB 761015 c.1209G>C synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoB 761027 c.1221A>G synonymous_variant 0.93 rifampicin Not assoc w R - Interim
rpoB 761036 c.1230G>C synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoB 761037 c.1231T>C synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoB 761051 c.1245G>C synonymous_variant 0.96 rifampicin Not assoc w R - Interim
rpoB 761097 c.1291_1293delAGCinsTCG synonymous_variant 0.97 rifampicin
rpoB 761102 c.1296A>G synonymous_variant 0.97 rifampicin
rpoB 761150 c.1344A>T synonymous_variant 0.97 rifampicin Not assoc w R - Interim
rpoB 761171 c.1365C>T synonymous_variant 0.97 rifampicin Not assoc w R - Interim
rpoB 761180 c.1374A>G synonymous_variant 0.97 rifampicin
rpoB 761183 c.1377T>G synonymous_variant 0.96 rifampicin
rpoB 761189 c.1383T>G synonymous_variant 0.96 rifampicin
rpoB 761220 c.1414_1416delTCGinsAGC synonymous_variant 0.95 rifampicin
rpoB 761249 c.1443A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 761255 c.1449T>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 761258 c.1452G>A synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 761261 c.1455G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 761579 c.1773G>C synonymous_variant 0.96 rifampicin Not assoc w R - Interim
rpoB 761627 c.1821C>T synonymous_variant 0.95 rifampicin Not assoc w R - Interim
rpoB 761636 c.1830G>C synonymous_variant 0.96 rifampicin Not assoc w R - Interim
rpoB 761645 c.1839C>G synonymous_variant 0.95 rifampicin Not assoc w R - Interim
rpoB 761648 c.1842T>C synonymous_variant 0.95 rifampicin
rpoB 761666 c.1860G>C synonymous_variant 1.0 rifampicin
rpoB 761675 c.1869G>C synonymous_variant 1.0 rifampicin
rpoB 761682 c.1876C>T synonymous_variant 1.0 rifampicin
rpoB 761687 c.1881C>T synonymous_variant 1.0 rifampicin
rpoB 761690 c.1884G>C synonymous_variant 1.0 rifampicin
rpoB 761693 c.1887G>C synonymous_variant 1.0 rifampicin
rpoB 761705 c.1899C>T synonymous_variant 1.0 rifampicin
rpoB 761732 c.1926C>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 761735 c.1929C>G synonymous_variant 1.0 rifampicin
rpoB 761747 c.1941G>C synonymous_variant 1.0 rifampicin
rpoB 761750 c.1944G>C synonymous_variant 1.0 rifampicin
rpoB 761765 c.1959T>G synonymous_variant 1.0 rifampicin
rpoB 761772 p.His656Ala missense_variant 1.0 rifampicin
rpoB 761778 p.Asn658Asp missense_variant 1.0 rifampicin
rpoB 761789 c.1983G>C synonymous_variant 1.0 rifampicin
rpoB 761790 c.1984_1986delCGTinsAG frameshift_variant&missense_variant 1.0 rifampicin
rpoB 761813 c.2007T>C synonymous_variant 1.0 rifampicin
rpoB 761814 p.Ala670Asn missense_variant 1.0 rifampicin
rpoB 761834 c.2028T>C synonymous_variant 1.0 rifampicin
rpoB 762078 c.2272C>T synonymous_variant 1.0 rifampicin
rpoB 762083 c.2277T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 762086 c.2280G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 762110 c.2304G>C synonymous_variant 1.0 rifampicin
rpoB 762140 c.2334G>C synonymous_variant 1.0 rifampicin
rpoB 762143 c.2337T>C synonymous_variant 1.0 rifampicin
rpoB 762149 c.2343G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 762170 c.2364C>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 762176 c.2370T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 762185 c.2379G>T synonymous_variant 1.0 rifampicin
rpoB 762362 p.Glu852Asp missense_variant 1.0 rifampicin
rpoB 762369 c.2563T>C synonymous_variant 1.0 rifampicin
rpoC 762374 c.-996G>C upstream_gene_variant 1.0 rifampicin
rpoC 762380 c.-990T>G upstream_gene_variant 1.0 rifampicin
rpoC 762395 c.-975G>C upstream_gene_variant 1.0 rifampicin
rpoC 762398 c.-972T>G upstream_gene_variant 1.0 rifampicin
rpoC 762401 c.-969G>C upstream_gene_variant 1.0 rifampicin
rpoB 762404 c.2598T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 762407 c.-963G>C upstream_gene_variant 1.0 rifampicin
rpoB 762410 c.2604T>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 762416 c.2610A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 762467 c.-903C>T upstream_gene_variant 1.0 rifampicin
rpoB 762486 p.Pro894Ala missense_variant 1.0 rifampicin
rpoB 762489 p.Val895Gln missense_variant 1.0 rifampicin
rpoC 762509 c.-861T>G upstream_gene_variant 0.97 rifampicin
rpoB 762510 p.Ala902Pro missense_variant 0.97 rifampicin Uncertain significance
rpoC 762518 c.-852C>A upstream_gene_variant 1.0 rifampicin
rpoC 762527 c.-843G>C upstream_gene_variant 1.0 rifampicin
rpoC 762533 c.-837T>C upstream_gene_variant 1.0 rifampicin
rpoC 762536 c.-834T>C upstream_gene_variant 1.0 rifampicin
rpoC 762551 c.-819C>T upstream_gene_variant 1.0 rifampicin
rpoC 762581 c.-789T>C upstream_gene_variant 1.0 rifampicin
rpoC 762582 c.-788T>C upstream_gene_variant 1.0 rifampicin
rpoC 763741 c.372C>T synonymous_variant 1.0 rifampicin
rpoC 763747 c.378G>A synonymous_variant 1.0 rifampicin
rpoC 763765 c.396T>C synonymous_variant 1.0 rifampicin
rpoC 763781 p.Ser138Ala missense_variant 0.96 rifampicin
rpoC 763792 p.Glu141Asp missense_variant 0.96 rifampicin
rpoC 763801 c.432C>G synonymous_variant 0.96 rifampicin
rpoC 763807 c.438T>C synonymous_variant 0.96 rifampicin Not assoc w R - Interim
rpoC 763813 c.444C>G synonymous_variant 0.96 rifampicin
rpoC 763816 c.447C>G synonymous_variant 0.96 rifampicin
rpoC 763819 c.450G>C synonymous_variant 0.96 rifampicin
rpoC 763825 c.456G>A synonymous_variant 0.97 rifampicin Not assoc w R - Interim
rpoC 763831 c.462A>G synonymous_variant 0.97 rifampicin
rpoC 763836 p.Ala156Gly missense_variant 0.97 rifampicin
rpoC 763858 c.489A>G synonymous_variant 0.97 rifampicin
rpoC 763867 c.498C>T synonymous_variant 0.97 rifampicin Not assoc w R - Interim
rpoC 763872 p.Gly168Ala missense_variant 0.97 rifampicin
rpoC 763876 p.Glu169Asp missense_variant 0.97 rifampicin
rpoC 763879 c.510A>G synonymous_variant 0.96 rifampicin
rpoC 763894 c.525A>G synonymous_variant 0.96 rifampicin
rpoC 763900 c.531G>C synonymous_variant 0.96 rifampicin Not assoc w R - Interim
rpoC 763903 c.534G>A synonymous_variant 0.96 rifampicin
rpoC 763912 c.543G>C synonymous_variant 0.97 rifampicin
rpoC 763933 c.564C>A synonymous_variant 1.0 rifampicin
rpoC 763945 c.576T>C synonymous_variant 1.0 rifampicin
rpoC 763960 c.591T>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 763963 c.594C>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 763972 c.603C>T synonymous_variant 1.0 rifampicin
rpoC 763987 c.618C>T synonymous_variant 1.0 rifampicin
rpoC 763991 c.622_624delATCinsCG frameshift_variant&missense_variant 1.0 rifampicin
rpoC 764002 c.633C>T synonymous_variant 1.0 rifampicin
rpoC 764005 c.636G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764011 c.642T>C synonymous_variant 1.0 rifampicin
rpoC 764014 c.645G>A synonymous_variant 1.0 rifampicin
rpoC 764024 c.655_657delTTGinsCC frameshift_variant&missense_variant 1.0 rifampicin
rpoC 764032 p.Asp221Glu missense_variant 1.0 rifampicin
rpoC 764040 p.Ser224Thr missense_variant 1.0 rifampicin
rpoC 764044 c.675T>G synonymous_variant 1.0 rifampicin
rpoC 764059 c.690G>C synonymous_variant 1.0 rifampicin
rpoC 764071 c.702G>C synonymous_variant 1.0 rifampicin
rpoC 764075 p.Val236Ile missense_variant 1.0 rifampicin Uncertain significance
rpoC 764083 c.714A>G synonymous_variant 1.0 rifampicin
rpoC 764085 p.Asn239Ser missense_variant 1.0 rifampicin Uncertain significance
rpoC 764087 p.Leu240Ile missense_variant 1.0 rifampicin
rpoC 764098 c.729A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764113 c.744C>T synonymous_variant 1.0 rifampicin
rpoC 764131 c.762T>C synonymous_variant 0.98 rifampicin
rpoC 764134 c.765C>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764188 c.819A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764191 c.822C>G synonymous_variant 1.0 rifampicin
rpoC 764203 c.834G>C synonymous_variant 1.0 rifampicin
rpoC 764206 c.837T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764213 p.Arg282Lys missense_variant 1.0 rifampicin Uncertain significance
rpoC 764227 c.858G>C synonymous_variant 1.0 rifampicin
rpoC 765493 c.2124G>C synonymous_variant 0.91 rifampicin
rpoC 765520 c.2151G>A synonymous_variant 0.93 rifampicin
rpoC 765529 c.2160C>G synonymous_variant 0.93 rifampicin
rpoC 765550 c.2181C>T synonymous_variant 0.94 rifampicin
rpoC 765553 c.2184C>T synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoC 765556 c.2187G>C synonymous_variant 0.94 rifampicin
rpoC 765559 c.2190G>C synonymous_variant 0.97 rifampicin
rpoC 765562 c.2193G>C synonymous_variant 0.97 rifampicin
rpoC 765565 c.2196G>C synonymous_variant 0.97 rifampicin
rpoC 765580 c.2211G>C synonymous_variant 0.97 rifampicin
rpoC 765611 p.His748Ala missense_variant 0.97 rifampicin
rpoC 765625 c.2256C>G synonymous_variant 0.97 rifampicin Not assoc w R - Interim
rpoC 765628 c.2259G>C synonymous_variant 0.97 rifampicin Not assoc w R - Interim
rpoC 765658 c.2289C>G synonymous_variant 1.0 rifampicin
rpoC 765661 c.2292T>G synonymous_variant 1.0 rifampicin
rpoC 765662 c.2293_2295delTTGinsCC frameshift_variant&missense_variant 1.0 rifampicin
rpoC 765669 p.His767Arg missense_variant 1.0 rifampicin
rpoC 765681 p.Asn771Thr missense_variant 1.0 rifampicin
rpoC 765700 c.2331T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 765712 c.2343C>G synonymous_variant 1.0 rifampicin
rpoC 765718 p.Asp783Glu missense_variant 1.0 rifampicin Uncertain significance
rpoC 765728 c.2359_2361delCAGinsAC frameshift_variant&missense_variant 1.0 rifampicin
rpoC 765734 c.2365T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 765751 c.2382C>G synonymous_variant 1.0 rifampicin
rpoC 765752 p.Asp795Ser missense_variant 1.0 rifampicin
rpoC 765772 c.2403C>G synonymous_variant 1.0 rifampicin
rpoC 765778 c.2409C>G synonymous_variant 1.0 rifampicin
rpoC 765781 p.Asp804Glu missense_variant 1.0 rifampicin
rpoC 765796 c.2427C>T synonymous_variant 1.0 rifampicin
rpoC 765811 c.2442T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 765814 c.2445A>C synonymous_variant 1.0 rifampicin
rpoC 765817 c.2448G>C synonymous_variant 1.0 rifampicin
rpoC 765826 c.2457T>G synonymous_variant 1.0 rifampicin
rpoC 765835 c.2466C>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 765850 c.2481G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 765875 p.Val836Ile missense_variant 1.0 rifampicin Uncertain significance
rpoC 766456 c.3087C>G synonymous_variant 1.0 rifampicin
rpoC 766459 c.3090G>C synonymous_variant 1.0 rifampicin
rpoC 766486 c.3117A>G synonymous_variant 1.0 rifampicin
rpoC 766492 c.3123T>C synonymous_variant 1.0 rifampicin
rpoC 766517 p.Thr1050Ala missense_variant 1.0 rifampicin
rpoC 766522 c.3153C>G synonymous_variant 0.97 rifampicin
rpoC 766525 c.3156G>C synonymous_variant 0.97 rifampicin
rpoC 766526 c.3157_3159delGTTinsAC frameshift_variant&missense_variant 0.97 rifampicin
rpoC 766531 c.3162G>C synonymous_variant 1.0 rifampicin
rpoC 766534 c.3165C>G synonymous_variant 1.0 rifampicin
rpoC 766540 p.Asp1057Glu missense_variant 1.0 rifampicin
rpoC 766542 p.Gly1058Asp missense_variant 1.0 rifampicin
rpoC 766564 c.3195C>G synonymous_variant 1.0 rifampicin
rpoC 766568 c.3199_3201delGTTinsAC frameshift_variant&missense_variant 1.0 rifampicin
rpoC 766573 c.3204T>C synonymous_variant 1.0 rifampicin
rpoC 766591 c.3222A>G synonymous_variant 1.0 rifampicin
rpoC 766592 p.Val1075Leu missense_variant 1.0 rifampicin
rpoC 767059 c.3690T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 767062 c.3693C>G synonymous_variant 1.0 rifampicin
mmpL5 777011 p.Lys490Thr missense_variant 1.0 clofazimine
bedaquiline
mmpL5 777017 p.Asp488Leu missense_variant 1.0 clofazimine
bedaquiline
mmpL5 777032 c.1449C>G synonymous_variant 1.0 clofazimine
bedaquiline
mmpL5 777044 p.Ser479Gly missense_variant 1.0 clofazimine
bedaquiline
mmpL5 777047 c.1434A>C synonymous_variant 1.0 clofazimine
bedaquiline
mmpL5 777050 c.1431G>C synonymous_variant 1.0 clofazimine Not assoc w R - Interim
bedaquiline Not assoc w R - Interim
mmpL5 777059 p.Ala474Gln missense_variant 1.0 clofazimine
bedaquiline
mmpL5 777065 c.1416T>C synonymous_variant 1.0 clofazimine
bedaquiline
mmpL5 777094 c.1387T>C synonymous_variant 1.0 clofazimine
bedaquiline
mmpL5 777095 c.1386T>C synonymous_variant 1.0 clofazimine
bedaquiline
mmpL5 777106 p.Ser459Pro missense_variant 1.0 clofazimine
bedaquiline
mmpL5 777107 c.1374T>C synonymous_variant 1.0 clofazimine
bedaquiline
mmpL5 777110 c.1371T>C synonymous_variant 1.0 clofazimine
bedaquiline
rpsL 781832 c.273T>C synonymous_variant 1.0 streptomycin
rplC 801171 c.363A>G synonymous_variant 1.0 linezolid
rplC 801183 c.375C>G synonymous_variant 1.0 linezolid
rplC 801205 p.Arg133Ala missense_variant 1.0 linezolid
rplC 801210 c.402T>A synonymous_variant 1.0 linezolid
rplC 801222 c.414T>C synonymous_variant 1.0 linezolid
rplC 801228 c.420T>C synonymous_variant 1.0 linezolid
rplC 801229 p.Ala141Thr missense_variant 1.0 linezolid
rplC 801246 c.438C>T synonymous_variant 1.0 linezolid
rplC 801249 c.441T>C synonymous_variant 1.0 linezolid
rplC 801252 c.444G>C synonymous_variant 1.0 linezolid
rplC 801264 c.456C>T synonymous_variant 1.0 linezolid
rplC 801267 c.459A>C synonymous_variant 1.0 linezolid
rplC 801270 c.462T>C synonymous_variant 1.0 linezolid
rplC 801276 c.468G>C synonymous_variant 1.0 linezolid
rplC 801279 c.471G>C synonymous_variant 0.8 linezolid
rplC 801312 c.504G>C synonymous_variant 1.0 linezolid
rplC 801324 c.516T>C synonymous_variant 1.0 linezolid
atpE 1461122 c.78C>T synonymous_variant 1.0 bedaquiline
atpE 1461132 p.Val30Ile missense_variant 1.0 bedaquiline
atpE 1461149 c.105T>G synonymous_variant 1.0 bedaquiline
atpE 1461153 p.Ser37Ala missense_variant 1.0 bedaquiline Uncertain significance
atpE 1461159 p.Val39Ile missense_variant 1.0 bedaquiline Uncertain significance
atpE 1461164 c.120C>A synonymous_variant 1.0 bedaquiline
atpE 1461167 c.123G>T synonymous_variant 1.0 bedaquiline
atpE 1461170 c.126A>G synonymous_variant 1.0 bedaquiline
atpE 1461179 c.135G>T synonymous_variant 1.0 bedaquiline
atpE 1461182 c.138A>G synonymous_variant 1.0 bedaquiline
atpE 1461185 c.141G>C synonymous_variant 1.0 bedaquiline
atpE 1461197 c.153A>C synonymous_variant 1.0 bedaquiline
atpE 1461212 c.168C>G synonymous_variant 1.0 bedaquiline
atpE 1461224 c.180T>G synonymous_variant 1.0 bedaquiline
atpE 1461230 c.186G>C synonymous_variant 1.0 bedaquiline
atpE 1461233 c.189A>G synonymous_variant 1.0 bedaquiline
atpE 1461254 c.210T>C synonymous_variant 1.0 bedaquiline
rrl 1475608 n.1951T>C non_coding_transcript_exon_variant 0.8 capreomycin Uncertain significance
linezolid
rrl 1475612 n.1955G>C non_coding_transcript_exon_variant 0.8 capreomycin Uncertain significance
linezolid
rrl 1475621 n.1964T>C non_coding_transcript_exon_variant 0.8 capreomycin Uncertain significance
linezolid
rrl 1475629 n.1973dupA non_coding_transcript_exon_variant 0.8 capreomycin Uncertain significance
linezolid
rrl 1475659 n.2002G>A non_coding_transcript_exon_variant 0.8 capreomycin Uncertain significance
linezolid Uncertain significance
inhA 1674507 c.306G>C synonymous_variant 1.0 ethionamide
isoniazid
inhA 1674514 p.Ile105Val missense_variant 1.0 ethionamide
isoniazid
inhA 1674534 c.333G>C synonymous_variant 1.0 ethionamide
isoniazid Not assoc w R - Interim
inhA 1674542 p.Ala114Glu missense_variant 1.0 ethionamide
isoniazid
inhA 1674546 c.345T>C synonymous_variant 1.0 ethionamide
isoniazid
inhA 1674549 c.348G>C synonymous_variant 1.0 ethionamide
isoniazid
inhA 1674550 p.Ser117Ala missense_variant 1.0 ethionamide
isoniazid
inhA 1674570 c.369G>C synonymous_variant 1.0 ethionamide
isoniazid
inhA 1674573 c.372G>C synonymous_variant 1.0 ethionamide
isoniazid
inhA 1674576 c.375T>C synonymous_variant 0.97 ethionamide
isoniazid
inhA 1674582 c.381T>C synonymous_variant 0.97 ethionamide
isoniazid
inhA 1674585 c.384T>G synonymous_variant 0.97 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
inhA 1674589 p.Met130Leu missense_variant 0.97 ethionamide
isoniazid
inhA 1674601 p.Leu134Val missense_variant 0.97 ethionamide
isoniazid
inhA 1674624 c.423A>C synonymous_variant 0.97 ethionamide
isoniazid
inhA 1674630 c.429C>G synonymous_variant 0.97 ethionamide
isoniazid
inhA 1674636 c.435C>G synonymous_variant 0.97 ethionamide
isoniazid
inhA 1674656 p.Ser152Thr missense_variant 0.95 ethionamide
isoniazid
inhA 1674687 c.486G>C synonymous_variant 0.92 ethionamide
isoniazid
inhA 1674690 c.489C>G synonymous_variant 0.92 ethionamide
isoniazid
inhA 1674696 c.495G>A synonymous_variant 0.92 ethionamide
isoniazid
rpsA 1834102 c.561T>G synonymous_variant 1.0 pyrazinamide
rpsA 1834144 c.603G>A synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
rpsA 1834150 c.609G>C synonymous_variant 1.0 pyrazinamide
rpsA 1834153 c.612T>C synonymous_variant 1.0 pyrazinamide
rpsA 1834154 p.Asn205His missense_variant 1.0 pyrazinamide
rpsA 1834157 c.616T>C synonymous_variant 1.0 pyrazinamide
rpsA 1834162 c.621A>G synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
rpsA 1834165 c.624A>G synonymous_variant 1.0 pyrazinamide
rpsA 1834169 p.Thr210Ala missense_variant 1.0 pyrazinamide Uncertain significance
rpsA 1834177 c.636A>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
rpsA 1834189 c.648G>C synonymous_variant 1.0 pyrazinamide
rpsA 1834222 c.681T>C synonymous_variant 1.0 pyrazinamide
rpsA 1834231 c.690T>G synonymous_variant 1.0 pyrazinamide
rpsA 1834240 c.699T>C synonymous_variant 1.0 pyrazinamide
rpsA 1834249 c.708T>C synonymous_variant 1.0 pyrazinamide
rpsA 1834261 c.720A>G synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
rpsA 1834264 c.723G>C synonymous_variant 1.0 pyrazinamide
rpsA 1834288 c.747C>G synonymous_variant 1.0 pyrazinamide
rpsA 1834294 c.753G>C synonymous_variant 0.93 pyrazinamide
rpsA 1834298 p.Gln253Ala missense_variant 0.93 pyrazinamide
rpsA 1834303 c.762T>C synonymous_variant 0.93 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.93 pyrazinamide
rpsA 1834336 c.795C>G synonymous_variant 0.93 pyrazinamide
tsnR 1853361 c.-245T>C upstream_gene_variant 1.0 linezolid
tsnR 1853370 c.-236_-234delGCAinsTG upstream_gene_variant 1.0 linezolid
tsnR 1853384 c.-222G>C upstream_gene_variant 1.0 linezolid
tsnR 1853387 c.-219T>C upstream_gene_variant 1.0 linezolid
tsnR 1853390 c.-216G>C upstream_gene_variant 0.92 linezolid
tsnR 1853394 c.-212_-211delCTinsGC upstream_gene_variant 1.0 linezolid
tsnR 1853417 c.-189G>C upstream_gene_variant 1.0 linezolid
tsnR 1853420 c.-186T>C upstream_gene_variant 1.0 linezolid
tsnR 1853429 c.-177G>C upstream_gene_variant 1.0 linezolid
tsnR 1853432 c.-174G>C upstream_gene_variant 1.0 linezolid
kasA 2518528 c.414C>G synonymous_variant 1.0 isoniazid
kasA 2518540 c.426T>G synonymous_variant 1.0 isoniazid
kasA 2518561 c.447T>C synonymous_variant 1.0 isoniazid
kasA 2518573 c.459G>C synonymous_variant 1.0 isoniazid
kasA 2518574 p.Ile154Ala missense_variant 1.0 isoniazid
kasA 2518579 c.465T>G synonymous_variant 1.0 isoniazid
kasA 2518585 c.471G>A synonymous_variant 1.0 isoniazid
kasA 2518588 c.474T>C synonymous_variant 1.0 isoniazid
kasA 2518591 c.477G>C synonymous_variant 1.0 isoniazid
kasA 2518606 c.492G>C synonymous_variant 1.0 isoniazid
kasA 2518609 p.Met165Ile missense_variant 1.0 isoniazid
kasA 2518612 c.498C>A synonymous_variant 1.0 isoniazid
kasA 2518630 c.516G>C synonymous_variant 1.0 isoniazid
kasA 2518636 c.522C>T synonymous_variant 1.0 isoniazid
kasA 2518639 c.525G>C synonymous_variant 1.0 isoniazid
kasA 2518642 c.528A>G synonymous_variant 1.0 isoniazid
kasA 2518663 c.549T>C synonymous_variant 1.0 isoniazid
kasA 2518672 c.558G>C synonymous_variant 1.0 isoniazid
kasA 2518678 c.564C>T synonymous_variant 1.0 isoniazid
kasA 2518684 c.570C>G synonymous_variant 1.0 isoniazid
kasA 2518825 c.711T>C synonymous_variant 1.0 isoniazid
kasA 2518843 c.729T>C synonymous_variant 1.0 isoniazid
kasA 2518847 p.Leu245Met missense_variant 1.0 isoniazid
kasA 2518853 p.Leu247Ile missense_variant 1.0 isoniazid
kasA 2518864 c.750G>C synonymous_variant 1.0 isoniazid
kasA 2518879 c.765A>G synonymous_variant 1.0 isoniazid
kasA 2518885 c.771T>C synonymous_variant 1.0 isoniazid
kasA 2518898 c.784T>C synonymous_variant 1.0 isoniazid
kasA 2518903 c.789C>T synonymous_variant 1.0 isoniazid
kasA 2518906 c.792A>G synonymous_variant 1.0 isoniazid
kasA 2518910 p.Leu266Met missense_variant 1.0 isoniazid
kasA 2518921 c.807T>A synonymous_variant 1.0 isoniazid
Rv2477c 2782957 c.1086A>G synonymous_variant 1.0 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2782969 c.1074A>C synonymous_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782981 c.1062G>C synonymous_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782984 c.1059T>C synonymous_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782987 c.1056C>G synonymous_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782990 c.1053C>G synonymous_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783002 c.1041T>C synonymous_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783013 c.1030T>C synonymous_variant 1.0 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783015 p.Ser343Thr missense_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783040 p.Ala335Thr missense_variant 1.0 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
kanamycin Uncertain significance
rifampicin Uncertain significance
amikacin Uncertain significance
Rv2477c 2783044 c.999G>A synonymous_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783048 p.Asp332Gly missense_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783051 p.Tyr331Phe missense_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783053 c.990C>T synonymous_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783059 c.984T>C synonymous_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783068 p.Asp325Glu missense_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783071 c.972C>G synonymous_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783077 c.966T>C synonymous_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783083 c.960G>C synonymous_variant 1.0 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783092 c.951A>G synonymous_variant 1.0 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783095 c.948C>G synonymous_variant 1.0 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R
amikacin Not assoc w R - Interim
Rv2477c 2783098 c.945C>G synonymous_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783116 c.927T>C synonymous_variant 0.96 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783131 c.912C>G synonymous_variant 0.92 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783140 c.903C>G synonymous_variant 0.9 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783149 c.894G>C synonymous_variant 0.83 ethambutol
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783158 c.885A>C synonymous_variant 0.8 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783395 c.648T>G synonymous_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783422 c.621T>G synonymous_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783425 p.Pro206Glu missense_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783432 p.Ser204Ala missense_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783440 c.603T>C synonymous_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783446 c.597A>G synonymous_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783464 c.579A>G synonymous_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783467 c.576G>C synonymous_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783473 c.570A>C synonymous_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783485 c.558G>C synonymous_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783499 c.544T>C synonymous_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783502 c.541T>C synonymous_variant 1.0 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783506 c.537C>T synonymous_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783509 c.534C>G synonymous_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783520 c.523T>C synonymous_variant 1.0 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783527 c.516A>G synonymous_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783548 c.495T>C synonymous_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783554 c.489C>G synonymous_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783557 c.486T>C synonymous_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783563 c.480A>C synonymous_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783566 p.Asn159Lys missense_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783572 c.471A>G synonymous_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783581 p.Asp154Glu missense_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783674 c.369T>C synonymous_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783683 c.360A>G synonymous_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783719 c.324A>G synonymous_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783737 c.306C>G synonymous_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783746 c.297G>A synonymous_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783751 p.Ile98Val missense_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783758 p.Asp95Glu missense_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783761 c.282G>C synonymous_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783764 c.277_279delATGinsCC frameshift_variant&missense_variant 1.0 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
kanamycin Uncertain significance
rifampicin Uncertain significance
amikacin Uncertain significance
Rv2477c 2783773 c.270A>G synonymous_variant 1.0 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783776 c.267G>C synonymous_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783779 c.264T>C synonymous_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783788 c.255T>C synonymous_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783797 p.Asp82Glu missense_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2752c 3065894 p.Ile100Leu missense_variant 1.0 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065901 c.291A>T synonymous_variant 1.0 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065907 c.285G>A synonymous_variant 1.0 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065919 c.273G>C synonymous_variant 1.0 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065922 c.270T>C synonymous_variant 1.0 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065940 c.252G>A synonymous_variant 1.0 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065946 p.Gly82Ala missense_variant 1.0 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065979 c.211_213delCTTinsGC frameshift_variant&missense_variant 1.0 ethambutol Uncertain significance
moxifloxacin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
Rv2752c 3065982 c.210G>C synonymous_variant 1.0 ethambutol Not assoc w R - Interim
moxifloxacin
levofloxacin
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
Rv2752c 3065988 c.204A>G synonymous_variant 1.0 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065993 p.Val67Ile missense_variant 1.0 ethambutol Uncertain significance
moxifloxacin
levofloxacin
rifampicin Uncertain significance
isoniazid Uncertain significance
Rv2752c 3065994 c.198T>C synonymous_variant 1.0 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066002 p.Met64Leu missense_variant 1.0 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066017 c.175C>T synonymous_variant 1.0 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066021 c.171C>G synonymous_variant 1.0 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066024 c.168T>C synonymous_variant 1.0 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066027 c.165C>G synonymous_variant 1.0 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066039 c.153C>T synonymous_variant 1.0 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
mtrB 3627227 c.-614T>G upstream_gene_variant 1.0 bedaquiline
rifampicin
mtrB 3627233 c.-620T>C upstream_gene_variant 1.0 bedaquiline
rifampicin
mtrB 3627236 c.-623T>C upstream_gene_variant 1.0 bedaquiline
rifampicin
mtrA 3627239 c.111C>T synonymous_variant 1.0 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
mtrB 3627263 c.-650C>T upstream_gene_variant 1.0 bedaquiline
rifampicin
mtrB 3627266 c.-653A>G upstream_gene_variant 1.0 bedaquiline
rifampicin
mtrB 3627272 c.-659G>T upstream_gene_variant 1.0 bedaquiline
rifampicin
mtrB 3627301 c.-688T>C upstream_gene_variant 1.0 bedaquiline
rifampicin
mtrB 3627305 c.-692T>G upstream_gene_variant 1.0 bedaquiline
rifampicin
mtrB 3627317 c.-704T>C upstream_gene_variant 1.0 bedaquiline
rifampicin
mtrA 3627323 c.25_27delTTGinsCC frameshift_variant&missense_variant 1.0 bedaquiline
rifampicin
mtrB 3627326 c.-713T>C upstream_gene_variant 1.0 bedaquiline
rifampicin
mtrA 3627336 p.Arg5Lys missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Uncertain significance
mtrA 3627343 p.Thr3Pro missense_variant 1.0 bedaquiline
rifampicin
rpoA 3877545 c.963G>C synonymous_variant 1.0 rifampicin
rpoA 3877557 c.951C>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoA 3877569 c.937_939delCCGinsGC frameshift_variant&missense_variant 1.0 rifampicin
rpoA 3877587 c.919_921delTCAinsGG frameshift_variant&missense_variant 1.0 rifampicin
rpoA 3877613 p.Ile299Val missense_variant 1.0 rifampicin
rpoA 3877656 c.852T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoA 3877668 c.840A>G synonymous_variant 1.0 rifampicin
rpoA 3877677 c.831G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoA 3877680 c.828G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoA 3877685 c.823C>T synonymous_variant 1.0 rifampicin
rpoA 3877686 c.822A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoA 3877689 c.819C>G synonymous_variant 1.0 rifampicin
rpoA 3877692 c.816G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoA 3877704 c.804G>C synonymous_variant 1.0 rifampicin
rpoA 3877707 c.801G>A synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoA 3877710 c.798C>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoA 3877731 c.777G>C synonymous_variant 1.0 rifampicin
rpoA 3877737 c.771G>C synonymous_variant 1.0 rifampicin
rpoA 3877743 c.765T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoA 3877764 c.744C>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoA 3877770 c.738A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoA 3877776 c.732T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoA 3877782 c.726T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoA 3878848 c.-341C>T upstream_gene_variant 0.9 rifampicin Uncertain significance
rpoA 3878853 c.-346G>A upstream_gene_variant 0.91 rifampicin
rpoA 3878938 c.-431T>C upstream_gene_variant 1.0 rifampicin
rpoA 3878947 c.-440G>C upstream_gene_variant 1.0 rifampicin Uncertain significance
rpoA 3878953 c.-446C>G upstream_gene_variant 1.0 rifampicin
rpoA 3878956 c.-449G>C upstream_gene_variant 1.0 rifampicin
rpoA 3878968 c.-461T>C upstream_gene_variant 1.0 rifampicin Uncertain significance
rpoA 3878976 c.-469A>G upstream_gene_variant 1.0 rifampicin Uncertain significance
clpC1 4038698 c.2007C>G synonymous_variant 0.94 pyrazinamide
clpC1 4038704 c.2001T>C synonymous_variant 0.94 pyrazinamide
clpC1 4038710 c.1995G>C synonymous_variant 0.94 pyrazinamide
clpC1 4038713 c.1992T>C synonymous_variant 0.97 pyrazinamide
clpC1 4038721 c.1984C>T synonymous_variant 0.98 pyrazinamide
clpC1 4038740 c.1965G>C synonymous_variant 0.98 pyrazinamide
clpC1 4038770 c.1935C>T synonymous_variant 1.0 pyrazinamide
clpC1 4038773 c.1932T>C synonymous_variant 1.0 pyrazinamide
clpC1 4038782 c.1923G>C synonymous_variant 1.0 pyrazinamide
clpC1 4038812 c.1893T>C synonymous_variant 1.0 pyrazinamide
clpC1 4038878 c.1827A>G synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4038905 c.1800A>C synonymous_variant 1.0 pyrazinamide
clpC1 4038908 c.1797C>G synonymous_variant 1.0 pyrazinamide
clpC1 4038911 c.1794G>C synonymous_variant 1.0 pyrazinamide
clpC1 4038914 c.1791G>C synonymous_variant 1.0 pyrazinamide
clpC1 4038923 c.1782A>G synonymous_variant 1.0 pyrazinamide
clpC1 4038932 c.1773G>C synonymous_variant 1.0 pyrazinamide
clpC1 4038953 c.1752A>G synonymous_variant 1.0 pyrazinamide
clpC1 4038956 c.1749T>C synonymous_variant 1.0 pyrazinamide
clpC1 4038965 c.1740T>C synonymous_variant 1.0 pyrazinamide
clpC1 4038971 c.1734T>C synonymous_variant 1.0 pyrazinamide
clpC1 4038974 c.1731T>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4038989 c.1716T>C synonymous_variant 1.0 pyrazinamide
clpC1 4038997 c.1708T>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4039001 c.1702_1704delAACinsGG frameshift_variant&missense_variant 1.0 pyrazinamide
clpC1 4039004 c.1701C>G synonymous_variant 1.0 pyrazinamide
clpC1 4039007 c.1698G>C synonymous_variant 1.0 pyrazinamide
clpC1 4039022 c.1683A>G synonymous_variant 1.0 pyrazinamide
clpC1 4039031 c.1674T>C synonymous_variant 1.0 pyrazinamide
clpC1 4039037 c.1668T>G synonymous_variant 1.0 pyrazinamide
clpC1 4039046 c.1659C>T synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4039064 c.1641C>G synonymous_variant 1.0 pyrazinamide
clpC1 4039073 c.1632C>G synonymous_variant 1.0 pyrazinamide
clpC1 4039076 c.1629G>A synonymous_variant 1.0 pyrazinamide
clpC1 4039079 c.1626C>G synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4039085 c.1620A>G synonymous_variant 1.0 pyrazinamide
clpC1 4039097 c.1608G>C synonymous_variant 1.0 pyrazinamide
clpC1 4039112 c.1593C>G synonymous_variant 1.0 pyrazinamide
clpC1 4039121 c.1584T>G synonymous_variant 1.0 pyrazinamide
clpC1 4039124 c.1581C>G synonymous_variant 1.0 pyrazinamide
clpC1 4039127 p.Lys526Asn missense_variant 0.98 pyrazinamide
clpC1 4039133 c.1572C>G synonymous_variant 1.0 pyrazinamide
clpC1 4039139 p.Glu522Asp missense_variant 1.0 pyrazinamide
clpC1 4039145 c.1560G>C synonymous_variant 1.0 pyrazinamide
clpC1 4039169 p.Glu512Asp missense_variant 1.0 pyrazinamide
clpC1 4039199 c.1506C>G synonymous_variant 1.0 pyrazinamide
clpC1 4039226 c.1479T>G synonymous_variant 1.0 pyrazinamide
clpC1 4039274 c.1431G>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4039286 c.1419T>C synonymous_variant 1.0 pyrazinamide
clpC1 4039292 c.1413C>G synonymous_variant 1.0 pyrazinamide
clpC1 4039295 c.1410A>C synonymous_variant 1.0 pyrazinamide
clpC1 4039304 c.1401G>A synonymous_variant 1.0 pyrazinamide
clpC1 4039320 p.Ala462Ser missense_variant 1.0 pyrazinamide
clpC1 4039322 c.1383T>C synonymous_variant 1.0 pyrazinamide
clpC1 4039328 c.1377A>C synonymous_variant 1.0 pyrazinamide
clpC1 4039338 p.Thr456Gln missense_variant 1.0 pyrazinamide
clpC1 4039347 p.Arg453Gln missense_variant 1.0 pyrazinamide Uncertain significance
clpC1 4039352 c.1353C>T synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4039391 c.1314T>G synonymous_variant 1.0 pyrazinamide
clpC1 4039409 c.1296T>C synonymous_variant 1.0 pyrazinamide
clpC1 4039412 p.Ala431Val missense_variant 1.0 pyrazinamide
clpC1 4039415 p.Glu430Asp missense_variant 1.0 pyrazinamide Uncertain significance
clpC1 4039430 c.1275T>C synonymous_variant 0.95 pyrazinamide
clpC1 4039442 c.1263A>G synonymous_variant 1.0 pyrazinamide
clpC1 4039448 c.1257A>G synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4039454 c.1251A>G synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4039463 c.1242C>G synonymous_variant 1.0 pyrazinamide
clpC1 4039466 c.1239T>C synonymous_variant 1.0 pyrazinamide
clpC1 4039469 c.1236T>C synonymous_variant 1.0 pyrazinamide
clpC1 4040393 c.312G>C synonymous_variant 0.92 pyrazinamide Not assoc w R - Interim
clpC1 4040411 c.294T>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4040423 c.282A>G synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4040426 c.279T>C synonymous_variant 1.0 pyrazinamide
clpC1 4040431 c.274T>C synonymous_variant 1.0 pyrazinamide
clpC1 4040441 c.262_264delCTCinsTG frameshift_variant&synonymous_variant 1.0 pyrazinamide
clpC1 4040444 c.261C>G synonymous_variant 1.0 pyrazinamide
clpC1 4040450 c.255A>G synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4040459 c.246C>G synonymous_variant 1.0 pyrazinamide
clpC1 4040465 c.240T>C synonymous_variant 0.96 pyrazinamide
clpC1 4040471 c.234T>C synonymous_variant 0.96 pyrazinamide Not assoc w R - Interim
clpC1 4040480 c.225T>C synonymous_variant 0.96 pyrazinamide Not assoc w R - Interim
clpC1 4040486 c.219G>A synonymous_variant 0.96 pyrazinamide
clpC1 4040522 c.183T>C synonymous_variant 0.89 pyrazinamide Not assoc w R - Interim
clpC1 4040531 c.174T>G synonymous_variant 0.92 pyrazinamide
clpC1 4040534 c.171A>G synonymous_variant 0.92 pyrazinamide Not assoc w R - Interim
clpC1 4040540 c.165G>C synonymous_variant 0.91 pyrazinamide
clpC1 4040551 c.154T>C synonymous_variant 0.89 pyrazinamide Not assoc w R - Interim
clpC1 4040561 c.144A>G synonymous_variant 0.87 pyrazinamide
embC 4238909 c.-954C>G upstream_gene_variant 1.0 ethambutol
embC 4238911 c.-952A>T upstream_gene_variant 1.0 ethambutol
embC 4238921 c.-942G>C upstream_gene_variant 1.0 ethambutol
embC 4238937 c.-926G>A upstream_gene_variant 1.0 ethambutol
embC 4238940 c.-923_-921delAGCinsTCG upstream_gene_variant 1.0 ethambutol
embC 4238944 c.-919A>G upstream_gene_variant 1.0 ethambutol
embC 4238966 c.-897C>T upstream_gene_variant 1.0 ethambutol
embC 4238969 c.-894A>G upstream_gene_variant 1.0 ethambutol
embC 4238975 c.-888A>C upstream_gene_variant 1.0 ethambutol
embC 4238986 c.-877_-876delCAinsAG upstream_gene_variant 1.0 ethambutol
embC 4238993 c.-870C>G upstream_gene_variant 1.0 ethambutol
embC 4238999 c.-864C>G upstream_gene_variant 1.0 ethambutol Uncertain significance
embC 4239012 c.-851T>A upstream_gene_variant 1.0 ethambutol
embC 4239023 c.-840C>G upstream_gene_variant 1.0 ethambutol
embC 4239027 c.-836_-834delATCinsCG upstream_gene_variant 1.0 ethambutol
embC 4239032 c.-831T>C upstream_gene_variant 1.0 ethambutol Uncertain significance
embC 4241039 p.Asp393Asn missense_variant 1.0 ethambutol
embC 4241047 c.1185C>G synonymous_variant 1.0 ethambutol
embC 4241050 c.1188T>G synonymous_variant 1.0 ethambutol
embC 4241053 c.1191G>C synonymous_variant 1.0 ethambutol
embC 4241059 c.1197G>A synonymous_variant 1.0 ethambutol
embC 4241083 c.1221G>T synonymous_variant 1.0 ethambutol
embC 4241084 c.1222C>T synonymous_variant 1.0 ethambutol
embC 4241107 c.1245G>C synonymous_variant 1.0 ethambutol
embC 4241140 c.1278A>G synonymous_variant 1.0 ethambutol Not assoc w R - Interim
embC 4241141 p.Ile427Val missense_variant 1.0 ethambutol Uncertain significance
embC 4241158 c.1296T>C synonymous_variant 1.0 ethambutol
embC 4241161 c.1299C>G synonymous_variant 1.0 ethambutol Not assoc w R - Interim
embC 4241162 c.1300T>C synonymous_variant 1.0 ethambutol
embC 4241185 c.1323G>C synonymous_variant 1.0 ethambutol
embC 4241188 c.1326C>G synonymous_variant 1.0 ethambutol
embC 4241189 c.1327_1329delATCinsGG frameshift_variant&missense_variant 1.0 ethambutol
embC 4241203 c.1341T>G synonymous_variant 1.0 ethambutol
embC 4241215 c.1353C>G synonymous_variant 1.0 ethambutol
embB 4248118 c.1605T>G synonymous_variant 0.9 ethambutol
embB 4248121 c.1608G>A synonymous_variant 0.91 ethambutol
embB 4248133 c.1620C>G synonymous_variant 0.94 ethambutol
embB 4248139 c.1626C>G synonymous_variant 0.95 ethambutol
embB 4248142 c.1629T>C synonymous_variant 0.95 ethambutol
embB 4248157 c.1644A>G synonymous_variant 0.96 ethambutol Not assoc w R - Interim
embB 4248173 p.Val554Met missense_variant 0.97 ethambutol
embB 4248179 p.Ile556Leu missense_variant 0.97 ethambutol
embB 4248185 c.1672T>C synonymous_variant 0.97 ethambutol
embB 4248194 p.Lys561Gly missense_variant 0.97 ethambutol
embB 4248199 c.1686A>G synonymous_variant 0.97 ethambutol
embB 4248200 p.Ile563Val missense_variant 0.97 ethambutol
embB 4248206 c.1693_1695delAGCinsGG frameshift_variant&missense_variant 0.97 ethambutol
embB 4248214 c.1701C>G synonymous_variant 0.98 ethambutol
embB 4248220 c.1707A>G synonymous_variant 0.98 ethambutol Not assoc w R - Interim
embB 4248232 c.1719G>A synonymous_variant 0.98 ethambutol Not assoc w R - Interim
embB 4248256 c.1743C>G synonymous_variant 1.0 ethambutol
embB 4248277 c.1764G>C synonymous_variant 1.0 ethambutol
embB 4248304 c.1791G>C synonymous_variant 1.0 ethambutol
embB 4248316 c.1803C>G synonymous_variant 1.0 ethambutol
embB 4248319 c.1806A>G synonymous_variant 1.0 ethambutol
embB 4248322 c.1809G>T synonymous_variant 1.0 ethambutol
embB 4248334 c.1821C>G synonymous_variant 0.96 ethambutol
embB 4248337 c.1824G>A synonymous_variant 0.96 ethambutol
embB 4248341 c.1828_1830delACGinsGC frameshift_variant&missense_variant 0.96 ethambutol
embB 4248355 c.1842A>C synonymous_variant 0.94 ethambutol
embB 4248358 c.1845C>G synonymous_variant 0.92 ethambutol
embB 4248360 p.Pro616Arg missense_variant 0.92 ethambutol
embB 4248375 p.Trp621Ser missense_variant 0.92 ethambutol Uncertain significance
embB 4248377 p.Ser622Ala missense_variant 0.91 ethambutol