TB-Profiler result

Run: SRR26399490
Summary

Run ID: SRR26399490

Sample name:

Date: 2024-04-15T01:26:40.520217

Number of reads: 108545

Percentage reads mapped: 58.0

Median coverage: 1.0

Strain: lineage4.9

Spoligotype:

Drug-resistance: Sensitive

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage4 Euro-American None 0.97
lineage4.9 Euro-American (H37Rv-like) None 1.0
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
gyrA 7514 c.213C>G synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 7517 c.216G>A synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 7520 c.219G>C synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 7523 c.222C>A synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 7538 c.237G>A synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 7541 c.240C>G synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7571 c.270G>C synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7592 c.291G>C synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7595 c.294C>G synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 7607 c.306C>G synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7626 c.325C>T synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 7631 c.330G>C synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 7652 c.351C>T synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 7658 c.357A>C synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7664 c.363T>C synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 7670 c.369A>C synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 7671 c.370_372delCCGinsGC frameshift_variant&missense_variant 1.0 levofloxacin
moxifloxacin
gyrA 7676 c.375G>C synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 7679 c.378G>C synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 7683 c.382_384delAGGinsCT frameshift_variant&missense_variant 1.0 levofloxacin
moxifloxacin
gyrA 7694 c.393A>G synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 7697 c.396C>T synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7715 c.414G>T synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 7728 c.427_429delAGGinsCC frameshift_variant&missense_variant 1.0 levofloxacin
moxifloxacin
gyrA 7745 c.444G>A synonymous_variant 0.96 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7758 c.457_459delATCinsGT frameshift_variant&missense_variant 0.95 levofloxacin
moxifloxacin
gyrA 7763 c.462T>G synonymous_variant 0.95 levofloxacin
moxifloxacin
gyrA 7784 c.483A>G synonymous_variant 0.9 levofloxacin
moxifloxacin
gyrA 7793 c.492G>C synonymous_variant 0.86 levofloxacin
moxifloxacin
gyrA 7799 c.498A>G synonymous_variant 0.86 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7814 c.513C>G synonymous_variant 0.86 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7820 c.519G>A synonymous_variant 0.86 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7832 c.531G>T synonymous_variant 0.86 levofloxacin
moxifloxacin
gyrA 7835 c.534A>C synonymous_variant 0.86 levofloxacin
moxifloxacin
gyrA 7841 c.540C>T synonymous_variant 0.86 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7853 c.552C>T synonymous_variant 0.84 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7859 c.558A>G synonymous_variant 0.82 levofloxacin
moxifloxacin
gyrA 7865 c.564T>C synonymous_variant 0.81 levofloxacin
moxifloxacin
gyrA 7886 c.585T>C synonymous_variant 0.8 levofloxacin
moxifloxacin
gyrA 8829 c.1528T>C synonymous_variant 0.92 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8834 c.1533C>T synonymous_variant 0.87 levofloxacin
moxifloxacin
gyrA 8852 c.1551T>C synonymous_variant 0.88 levofloxacin
moxifloxacin
gyrA 8855 c.1554C>T synonymous_variant 0.88 levofloxacin
moxifloxacin
gyrA 8858 c.1557T>C synonymous_variant 0.88 levofloxacin
moxifloxacin
gyrA 8861 c.1560C>T synonymous_variant 0.88 levofloxacin
moxifloxacin
gyrA 8867 c.1566A>G synonymous_variant 0.9 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8870 c.1569G>C synonymous_variant 0.91 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8873 c.1572A>C synonymous_variant 0.92 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8903 c.1602T>C synonymous_variant 0.94 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8909 c.1608C>T synonymous_variant 0.94 levofloxacin
moxifloxacin
gyrA 8915 c.1614A>G synonymous_variant 0.94 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8918 c.1617C>G synonymous_variant 0.94 levofloxacin
moxifloxacin
gyrA 8933 c.1632G>A synonymous_variant 0.94 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8939 c.1638T>C synonymous_variant 0.94 levofloxacin
moxifloxacin
gyrA 8942 c.1641G>C synonymous_variant 0.93 levofloxacin
moxifloxacin
gyrA 8945 c.1644G>C synonymous_variant 0.93 levofloxacin
moxifloxacin
gyrA 8946 c.1645_1647delTTGinsCC frameshift_variant&missense_variant 0.93 levofloxacin
moxifloxacin
gyrA 9092 c.1791C>G synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 9096 c.1795C>T synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 9099 c.1798_1800delTTAinsCG frameshift_variant&missense_variant 1.0 levofloxacin
moxifloxacin
gyrA 9116 c.1815G>A synonymous_variant 0.95 levofloxacin
moxifloxacin
gyrA 9119 c.1818A>G synonymous_variant 0.95 levofloxacin
moxifloxacin
gyrA 9128 c.1827C>T synonymous_variant 0.95 levofloxacin
moxifloxacin
gyrA 9143 c.1842T>C synonymous_variant 0.95 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9144 p.Arg615Lys missense_variant 0.95 levofloxacin
moxifloxacin
gyrA 9153 p.Thr618Glu missense_variant 0.95 levofloxacin
moxifloxacin
gyrA 9161 c.1860C>G synonymous_variant 0.95 levofloxacin
moxifloxacin
gyrA 9167 c.1866C>T synonymous_variant 0.95 levofloxacin
moxifloxacin
gyrA 9174 c.1873C>T synonymous_variant 0.95 levofloxacin
moxifloxacin
gyrA 9182 c.1881T>C synonymous_variant 0.95 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9191 c.1890G>A synonymous_variant 0.95 levofloxacin
moxifloxacin
gyrA 9197 c.1896G>C synonymous_variant 0.95 levofloxacin
moxifloxacin
gyrA 9200 c.1899A>G synonymous_variant 0.95 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9227 c.1926C>G synonymous_variant 0.92 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9230 c.1929T>C synonymous_variant 0.91 levofloxacin
moxifloxacin
gyrA 9236 c.1935G>C synonymous_variant 0.9 levofloxacin
moxifloxacin
gyrA 9239 c.1938C>T synonymous_variant 0.9 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9242 c.1941A>C synonymous_variant 0.92 levofloxacin
moxifloxacin
gyrA 9252 p.Val651Ile missense_variant 0.91 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9276 c.1975C>T synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 9281 c.1980C>G synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 9284 c.1983T>C synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 9288 p.Val663Met missense_variant 1.0 levofloxacin
moxifloxacin
gyrA 9299 c.1998G>C synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9304 p.Gly668Glu missense_variant 1.0 levofloxacin
moxifloxacin
gyrA 9315 c.2014C>T synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9323 c.2022C>G synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9330 p.Asn677Leu missense_variant 1.0 levofloxacin
moxifloxacin
gyrA 9335 c.2034G>A synonymous_variant 1.0 levofloxacin
moxifloxacin
mshA 575770 c.423G>C synonymous_variant 1.0 ethionamide
isoniazid
mshA 575772 p.Val142Ala missense_variant 1.0 ethionamide
isoniazid
mshA 575785 c.438T>C synonymous_variant 1.0 ethionamide
isoniazid
mshA 575786 p.Tyr147His missense_variant 1.0 ethionamide
isoniazid
mshA 575795 p.Ile150Val missense_variant 1.0 ethionamide
isoniazid
mshA 575803 c.456C>T synonymous_variant 1.0 ethionamide
isoniazid Not assoc w R - Interim
mshA 575818 c.471G>T synonymous_variant 1.0 ethionamide
isoniazid
mshA 575821 c.474G>C synonymous_variant 1.0 ethionamide
isoniazid
mshA 575840 c.494dupC frameshift_variant 1.0 ethionamide Uncertain significance
isoniazid Uncertain significance
mshA 575844 c.498delC frameshift_variant 1.0 ethionamide Uncertain significance
isoniazid Uncertain significance
mshA 575851 c.504C>G synonymous_variant 1.0 ethionamide
isoniazid
mshA 575864 c.517T>C synonymous_variant 1.0 ethionamide
isoniazid
mshA 575878 c.531A>G synonymous_variant 1.0 ethionamide
isoniazid
nusG 734407 c.154_156delGTTinsAC frameshift_variant&missense_variant 0.88 rifampicin
nusG 734421 c.168A>C synonymous_variant 0.92 rifampicin
nusG 734439 c.186C>G synonymous_variant 0.93 rifampicin
nusG 734442 c.189G>A synonymous_variant 0.93 rifampicin
nusG 734451 c.198G>C synonymous_variant 0.93 rifampicin
nusG 734454 c.201A>G synonymous_variant 0.93 rifampicin
nusG 734460 c.207G>C synonymous_variant 0.93 rifampicin
nusG 734472 c.219T>C synonymous_variant 0.96 rifampicin
nusG 734475 c.222T>C synonymous_variant 0.96 rifampicin Not assoc w R - Interim
nusG 734502 c.249G>A synonymous_variant 1.0 rifampicin
nusG 734532 c.279A>G synonymous_variant 0.96 rifampicin Not assoc w R - Interim
nusG 734541 c.288A>G synonymous_variant 0.96 rifampicin Not assoc w R - Interim
rpoB 761222 c.1416G>C synonymous_variant 0.8 rifampicin
rpoB 761240 c.1434C>T synonymous_variant 0.92 rifampicin
rpoB 761249 c.1443A>G synonymous_variant 0.93 rifampicin Not assoc w R - Interim
rpoB 761255 c.1449T>G synonymous_variant 0.93 rifampicin Not assoc w R - Interim
rpoB 761258 c.1452G>A synonymous_variant 0.93 rifampicin Not assoc w R - Interim
rpoB 761261 c.1455G>C synonymous_variant 0.93 rifampicin Not assoc w R - Interim
rpoB 761282 c.1476C>A synonymous_variant 0.93 rifampicin
rpoB 761300 c.1494G>A synonymous_variant 0.93 rifampicin Not assoc w R - Interim
rpoB 761318 c.1512G>C synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoB 761327 c.1521A>G synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoB 761330 c.1524G>C synonymous_variant 0.92 rifampicin
rpoB 761345 c.1539G>C synonymous_variant 0.92 rifampicin
rpoB 761346 p.Val514Asn missense_variant 0.9 rifampicin
rpoC 765478 c.2109T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 765523 c.2154C>T synonymous_variant 0.96 rifampicin
rpoC 765533 p.Tyr722His missense_variant 0.96 rifampicin Uncertain significance
rpoC 765547 c.2178C>T synonymous_variant 0.96 rifampicin Not assoc w R - Interim
rpoC 765548 c.2179_2181delAGCinsTCG synonymous_variant 0.96 rifampicin
rpoC 765553 c.2184C>A synonymous_variant 0.96 rifampicin
rpoC 765556 c.2187G>C synonymous_variant 0.96 rifampicin
rpoC 765562 c.2193G>C synonymous_variant 0.97 rifampicin
rpoC 765611 p.His748Ser missense_variant 0.96 rifampicin Uncertain significance
rpoC 765625 c.2256C>T synonymous_variant 0.96 rifampicin
rpoC 765628 c.2259G>C synonymous_variant 0.96 rifampicin Not assoc w R - Interim
rpoC 765635 c.2266_2268delGTCinsCG frameshift_variant&missense_variant 0.95 rifampicin
rpoC 765640 c.2271A>G synonymous_variant 0.95 rifampicin
rpsL 781859 c.300T>C synonymous_variant 1.0 streptomycin Not assoc w R - Interim
rpsL 781868 c.309T>C synonymous_variant 1.0 streptomycin
rpsL 781871 c.312G>C synonymous_variant 1.0 streptomycin
rpsL 781877 c.318T>A synonymous_variant 1.0 streptomycin
rpsL 781892 c.333A>G synonymous_variant 1.0 streptomycin
rpsL 781898 c.339A>C synonymous_variant 1.0 streptomycin
rpsL 781907 c.348T>C synonymous_variant 1.0 streptomycin
rpsL 781916 c.357T>G synonymous_variant 1.0 streptomycin
rpsL 781929 p.Gly124Ser missense_variant 1.0 streptomycin Uncertain significance
inhA 1674507 c.306G>C synonymous_variant 0.95 ethionamide
isoniazid
inhA 1674534 c.333G>C synonymous_variant 0.96 ethionamide
isoniazid Not assoc w R - Interim
inhA 1674542 p.Ala114Glu missense_variant 0.96 ethionamide
isoniazid
inhA 1674546 c.345T>C synonymous_variant 0.96 ethionamide
isoniazid
inhA 1674549 c.348G>C synonymous_variant 0.96 ethionamide
isoniazid
inhA 1674550 p.Ser117Ala missense_variant 0.96 ethionamide
isoniazid
inhA 1674573 c.372G>C synonymous_variant 0.94 ethionamide
isoniazid
inhA 1674576 c.375T>C synonymous_variant 0.94 ethionamide
isoniazid
inhA 1674579 c.378G>C synonymous_variant 0.94 ethionamide
isoniazid
inhA 1674585 c.384T>C synonymous_variant 0.94 ethionamide
isoniazid
inhA 1674589 p.Met130Leu missense_variant 0.95 ethionamide
isoniazid
inhA 1674597 c.396G>A synonymous_variant 0.95 ethionamide
isoniazid
inhA 1674601 p.Leu134Val missense_variant 0.95 ethionamide
isoniazid
inhA 1674624 c.423A>T synonymous_variant 0.94 ethionamide
isoniazid
inhA 1674627 c.426T>C synonymous_variant 0.94 ethionamide
isoniazid
inhA 1674628 p.Ser143Gly missense_variant 0.94 ethionamide
isoniazid
inhA 1674639 c.438C>T synonymous_variant 0.94 ethionamide
isoniazid
inhA 1674656 p.Ser152Thr missense_variant 0.96 ethionamide
isoniazid
inhA 1674663 c.462G>A synonymous_variant 0.97 ethionamide
isoniazid
inhA 1674690 c.489C>G synonymous_variant 0.96 ethionamide
isoniazid
inhA 1674702 c.501G>C synonymous_variant 0.92 ethionamide
isoniazid
inhA 1674703 c.502T>C synonymous_variant 0.92 ethionamide
isoniazid
inhA 1674714 c.513C>G synonymous_variant 0.9 ethionamide
isoniazid
inhA 1674718 c.517_519delAGGinsCA frameshift_variant&missense_variant 0.94 ethionamide
isoniazid
inhA 1674741 c.540C>A synonymous_variant 0.91 ethionamide
isoniazid
inhA 1674742 p.Lys181Gln missense_variant 0.96 ethionamide
isoniazid
inhA 1674745 p.Tyr182Val missense_variant 0.96 ethionamide
isoniazid
inhA 1674756 c.555T>G synonymous_variant 0.97 ethionamide
isoniazid
inhA 1674765 c.564C>G synonymous_variant 0.97 ethionamide
isoniazid
inhA 1674771 c.570C>G synonymous_variant 0.97 ethionamide
isoniazid
inhA 1674774 c.573A>C synonymous_variant 0.97 ethionamide
isoniazid
inhA 1674777 c.576C>G synonymous_variant 0.94 ethionamide
isoniazid
inhA 1674780 c.579T>G synonymous_variant 0.97 ethionamide
isoniazid
inhA 1674789 c.588G>C synonymous_variant 0.97 ethionamide
isoniazid
inhA 1674801 c.600T>C synonymous_variant 0.97 ethionamide
isoniazid
inhA 1674825 c.624C>T synonymous_variant 0.93 ethionamide
isoniazid Not assoc w R - Interim
inhA 1674828 c.627G>A synonymous_variant 0.89 ethionamide
isoniazid
inhA 1674830 p.Glu210Gly missense_variant 0.89 ethionamide
isoniazid
inhA 1674839 p.Ala213Glu missense_variant 0.86 ethionamide
isoniazid
inhA 1674846 c.645C>T synonymous_variant 0.86 ethionamide
isoniazid
inhA 1674848 p.Gln216Arg missense_variant 0.86 ethionamide
isoniazid Uncertain significance
inhA 1674855 c.654C>G synonymous_variant 0.89 ethionamide
isoniazid Not assoc w R - Interim
inhA 1674870 c.669T>C synonymous_variant 0.9 ethionamide
isoniazid
inhA 1674876 c.675C>T synonymous_variant 0.88 ethionamide
isoniazid
inhA 1674879 c.678T>C synonymous_variant 0.88 ethionamide
isoniazid
inhA 1674888 c.687C>T synonymous_variant 0.88 ethionamide
isoniazid
inhA 1674892 p.Asn231Asp missense_variant 0.88 ethionamide Uncertain significance
isoniazid Uncertain significance
inhA 1674903 c.702T>C synonymous_variant 0.83 ethionamide
isoniazid
inhA 1674904 p.Ala235Pro missense_variant 0.8 ethionamide
isoniazid
inhA 1674915 c.714C>G synonymous_variant 0.79 ethionamide
isoniazid
inhA 1674924 c.723G>C synonymous_variant 0.71 ethionamide
isoniazid
inhA 1674927 c.726G>C synonymous_variant 0.71 ethionamide
isoniazid
inhA 1674933 c.732G>C synonymous_variant 0.69 ethionamide
isoniazid
inhA 1674934 c.733C>T synonymous_variant 0.69 ethionamide
isoniazid
inhA 1674939 c.738G>C synonymous_variant 0.69 ethionamide
isoniazid
inhA 1674942 c.741T>C synonymous_variant 0.69 ethionamide
isoniazid
rpsA 1834240 c.699T>C synonymous_variant 1.0 pyrazinamide
rpsA 1834249 c.708T>C synonymous_variant 1.0 pyrazinamide
rpsA 1834261 c.720A>G synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
rpsA 1834264 c.723G>C synonymous_variant 1.0 pyrazinamide
rpsA 1834294 c.753G>C synonymous_variant 1.0 pyrazinamide
rpsA 1834297 c.756C>T synonymous_variant 1.0 pyrazinamide
rpsA 1834303 c.762T>G synonymous_variant 1.0 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 1.0 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
rpsA 1834361 c.820T>C synonymous_variant 1.0 pyrazinamide
rpsA 1834366 c.825A>G synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
rpsA 1834375 c.834G>C synonymous_variant 1.0 pyrazinamide
rpsA 1834396 c.855G>C synonymous_variant 1.0 pyrazinamide
rpsA 1834411 c.870T>C synonymous_variant 1.0 pyrazinamide
rpsA 1834423 c.882G>T synonymous_variant 1.0 pyrazinamide
rpsA 1834432 c.891G>C synonymous_variant 1.0 pyrazinamide
rpsA 1834451 c.910T>C synonymous_variant 1.0 pyrazinamide
rpsA 1834456 c.915T>G synonymous_variant 1.0 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 1.0 pyrazinamide
rpsA 1834477 c.936C>T synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
rpsA 1834489 c.948T>C synonymous_variant 1.0 pyrazinamide
rpsA 1834498 c.957C>T synonymous_variant 1.0 pyrazinamide
rpsA 1834522 c.981C>T synonymous_variant 0.96 pyrazinamide
rpsA 1834527 p.Arg329His missense_variant 0.96 pyrazinamide
rpsA 1834540 c.999G>C synonymous_variant 0.97 pyrazinamide
rpsA 1834543 c.1002C>G synonymous_variant 0.97 pyrazinamide
rpsA 1834546 c.1005T>C synonymous_variant 0.97 pyrazinamide
rpsA 1834555 c.1014T>C synonymous_variant 0.97 pyrazinamide
rpsA 1834558 c.1017C>G synonymous_variant 0.97 pyrazinamide
rpsA 1834570 c.1029C>T synonymous_variant 0.97 pyrazinamide Not assoc w R - Interim
rpsA 1834573 c.1032G>C synonymous_variant 0.97 pyrazinamide
rpsA 1834603 p.Glu354Asp missense_variant 0.95 pyrazinamide
rpsA 1834609 c.1068T>C synonymous_variant 0.94 pyrazinamide
rpsA 1834619 c.1078T>C synonymous_variant 0.94 pyrazinamide
rpsA 1834666 c.1125G>C synonymous_variant 1.0 pyrazinamide
rpsA 1834667 p.Ala376Ser missense_variant 1.0 pyrazinamide
rpsA 1834690 c.1149T>C synonymous_variant 0.96 pyrazinamide
rpsA 1834732 c.1191T>C synonymous_variant 0.97 pyrazinamide
rpsA 1834738 p.Glu399Asp missense_variant 0.95 pyrazinamide
rpsA 1834747 c.1206A>G synonymous_variant 0.95 pyrazinamide
rpsA 1834751 c.1210_1212delCTTinsAC frameshift_variant&missense_variant 0.95 pyrazinamide Uncertain significance
rpsA 1834756 p.Glu405Asp missense_variant 0.93 pyrazinamide
rpsA 1834759 c.1218A>T synonymous_variant 0.93 pyrazinamide
rpsA 1834765 p.Glu408Asp missense_variant 0.93 pyrazinamide
rpsA 1834775 p.Ala412Thr missense_variant 0.93 pyrazinamide
rpsA 1834780 c.1239A>G synonymous_variant 0.93 pyrazinamide
rpsA 1834786 c.1245A>G synonymous_variant 0.9 pyrazinamide
rpsA 1834789 c.1248T>C synonymous_variant 0.9 pyrazinamide
rpsA 1834792 c.1251G>C synonymous_variant 0.9 pyrazinamide
rpsA 1834829 p.Ala430Thr missense_variant 0.86 pyrazinamide
kasA 2518636 c.522C>T synonymous_variant 0.92 isoniazid
kasA 2518642 c.528A>G synonymous_variant 0.92 isoniazid
kasA 2518648 c.534C>T synonymous_variant 0.92 isoniazid
kasA 2518651 c.537C>G synonymous_variant 0.92 isoniazid
kasA 2518672 c.558G>C synonymous_variant 0.83 isoniazid
kasA 2518684 c.570C>G synonymous_variant 0.83 isoniazid
kasA 2518688 p.Val192Phe missense_variant 0.83 isoniazid
kasA 2518693 c.579C>G synonymous_variant 0.83 isoniazid
ahpC 2726571 p.Ala127Ser missense_variant 0.5 isoniazid
ahpC 2726579 c.387T>C synonymous_variant 0.58 isoniazid
ahpC 2726582 c.390G>C synonymous_variant 0.54 isoniazid
ahpC 2726591 c.399C>G synonymous_variant 0.58 isoniazid
ahpC 2726593 p.Val134Ala missense_variant 0.58 isoniazid
ahpC 2726600 c.408T>C synonymous_variant 0.64 isoniazid
ahpC 2726604 p.Val138Ile missense_variant 0.64 isoniazid
ahpC 2726624 c.432C>T synonymous_variant 0.7 isoniazid Not assoc w R - Interim
ahpC 2726638 p.Ala149Val missense_variant 0.7 isoniazid
ahpC 2726642 c.450C>G synonymous_variant 0.7 isoniazid
ahpC 2726645 c.453C>G synonymous_variant 0.64 isoniazid
ahpC 2726648 c.456T>A synonymous_variant 0.64 isoniazid
ahpC 2726657 c.465A>C synonymous_variant 0.64 isoniazid Not assoc w R - Interim
ahpC 2726666 c.474C>T synonymous_variant 0.64 isoniazid
ahpC 2726669 c.477T>C synonymous_variant 0.64 isoniazid
ahpC 2726675 c.483A>G synonymous_variant 0.64 isoniazid
ahpC 2726681 c.489A>G synonymous_variant 0.64 isoniazid
ahpC 2726687 c.495C>G synonymous_variant 0.64 isoniazid
ahpC 2726693 c.501C>A synonymous_variant 0.64 isoniazid
ahpC 2726696 c.504C>G synonymous_variant 0.64 isoniazid
lpqB 3624353 c.558C>G synonymous_variant 0.89 bedaquiline
rifampicin
lpqB 3624362 c.549G>C synonymous_variant 0.9 bedaquiline
rifampicin
lpqB 3624374 c.537G>C synonymous_variant 0.86 bedaquiline
rifampicin
lpqB 3624377 c.534C>G synonymous_variant 0.86 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3624389 c.522C>G synonymous_variant 0.86 bedaquiline
rifampicin
lpqB 3624396 p.Ala172Val missense_variant 0.86 bedaquiline
rifampicin
lpqB 3624404 c.507G>C synonymous_variant 0.9 bedaquiline
rifampicin
lpqB 3624407 c.504C>G synonymous_variant 0.9 bedaquiline
rifampicin
lpqB 3624416 c.495G>A synonymous_variant 0.9 bedaquiline
rifampicin
lpqB 3624422 c.489G>C synonymous_variant 0.95 bedaquiline
rifampicin
lpqB 3624425 p.Glu162Ala missense_variant 0.95 bedaquiline
rifampicin
lpqB 3624428 c.483A>G synonymous_variant 0.95 bedaquiline
rifampicin
lpqB 3624464 c.447A>G synonymous_variant 0.94 bedaquiline
rifampicin
lpqB 3624467 c.444C>G synonymous_variant 0.94 bedaquiline
rifampicin
lpqB 3624470 c.441T>C synonymous_variant 0.94 bedaquiline
rifampicin
lpqB 3624485 c.426T>C synonymous_variant 0.86 bedaquiline
rifampicin
lpqB 3624491 c.420G>C synonymous_variant 0.82 bedaquiline
rifampicin
mtrB 3625699 c.915C>T synonymous_variant 0.92 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625729 c.885A>G synonymous_variant 0.93 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625732 c.882C>T synonymous_variant 0.93 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625744 c.870G>A synonymous_variant 0.93 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625747 c.867G>C synonymous_variant 0.93 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625750 c.864G>A synonymous_variant 0.93 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625755 p.Ala287Thr missense_variant 0.93 bedaquiline
rifampicin Uncertain significance
mtrB 3625761 p.Gln285Glu missense_variant 0.92 bedaquiline
rifampicin Uncertain significance
mtrB 3625762 c.852A>T synonymous_variant 0.92 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625765 c.849C>G synonymous_variant 0.85 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625768 c.-858G>C upstream_gene_variant 0.94 bedaquiline
rifampicin
mtrB 3625806 c.808A>C synonymous_variant 1.0 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625819 c.795G>A synonymous_variant 1.0 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625822 c.-912C>T upstream_gene_variant 1.0 bedaquiline
rifampicin
mtrB 3625837 c.777C>G synonymous_variant 1.0 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625864 c.-954T>G upstream_gene_variant 1.0 bedaquiline
rifampicin
mtrB 3625867 c.747A>G synonymous_variant 1.0 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625899 p.Val239Leu missense_variant 1.0 bedaquiline
rifampicin
lpqB 3625906 c.-996G>A upstream_gene_variant 1.0 bedaquiline
rifampicin
lpqB 3625909 c.-999T>G upstream_gene_variant 1.0 bedaquiline
rifampicin
mtrB 3625915 c.699G>A synonymous_variant 1.0 bedaquiline
rifampicin
mtrB 3625923 c.691C>T synonymous_variant 1.0 bedaquiline
rifampicin
mtrB 3625924 c.690G>T synonymous_variant 1.0 bedaquiline
rifampicin
mtrB 3625927 c.687T>C synonymous_variant 1.0 bedaquiline
rifampicin
mtrB 3625930 c.684C>T synonymous_variant 1.0 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
mtrB 3625936 c.678C>G synonymous_variant 1.0 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625942 c.672C>G synonymous_variant 1.0 bedaquiline
rifampicin
mtrB 3625945 c.669A>G synonymous_variant 1.0 bedaquiline
rifampicin
mtrB 3625951 c.663A>G synonymous_variant 1.0 bedaquiline
rifampicin
mtrB 3626927 c.-314G>C upstream_gene_variant 0.73 bedaquiline
rifampicin
mtrB 3626930 c.-317A>G upstream_gene_variant 0.79 bedaquiline
rifampicin
mtrA 3626939 p.Glu137Asp missense_variant 0.81 bedaquiline
rifampicin
mtrA 3626942 c.406_408delGTAinsAC frameshift_variant&missense_variant 0.81 bedaquiline
rifampicin
mtrB 3626954 c.-341C>G upstream_gene_variant 0.84 bedaquiline
rifampicin
mtrB 3626969 c.-356C>G upstream_gene_variant 0.86 bedaquiline
rifampicin
mtrB 3626972 c.-359A>G upstream_gene_variant 0.86 bedaquiline
rifampicin
mtrB 3626993 c.-380G>C upstream_gene_variant 0.91 bedaquiline
rifampicin
mtrB 3627008 c.-395G>C upstream_gene_variant 0.95 bedaquiline
rifampicin
mtrB 3627011 c.-398T>G upstream_gene_variant 0.91 bedaquiline
rifampicin
mtrA 3627068 c.282T>G synonymous_variant 0.9 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627071 c.-458G>C upstream_gene_variant 0.9 bedaquiline
rifampicin
mtrA 3627080 c.270T>C synonymous_variant 0.92 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627083 c.-470G>C upstream_gene_variant 0.92 bedaquiline
rifampicin
mtrA 3627098 c.252A>C synonymous_variant 0.92 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3627119 c.231T>G synonymous_variant 0.86 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627122 c.-509T>C upstream_gene_variant 0.86 bedaquiline
rifampicin
mtrB 3627128 c.-515T>C upstream_gene_variant 0.85 bedaquiline
rifampicin
mtrA 3627131 p.Ala73Lys missense_variant 0.85 bedaquiline
rifampicin
mtrB 3627139 c.-526T>C upstream_gene_variant 0.85 bedaquiline
rifampicin
mtrA 3627146 c.204C>T synonymous_variant 0.85 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627149 c.-536G>C upstream_gene_variant 0.85 bedaquiline
rifampicin
mtrB 3627167 c.-554T>C upstream_gene_variant 0.8 bedaquiline
rifampicin
clpC1 4038953 c.1752A>G synonymous_variant 0.92 pyrazinamide
clpC1 4038965 c.1740T>C synonymous_variant 0.93 pyrazinamide
clpC1 4038971 c.1734T>C synonymous_variant 0.93 pyrazinamide
clpC1 4038974 c.1731T>C synonymous_variant 0.93 pyrazinamide Not assoc w R - Interim
clpC1 4038989 c.1716T>C synonymous_variant 0.93 pyrazinamide
clpC1 4038997 c.1708T>C synonymous_variant 0.93 pyrazinamide Not assoc w R - Interim
clpC1 4039001 c.1702_1704delAACinsGG frameshift_variant&missense_variant 0.93 pyrazinamide
clpC1 4039004 c.1701C>G synonymous_variant 0.93 pyrazinamide
clpC1 4039022 c.1683A>G synonymous_variant 0.93 pyrazinamide
clpC1 4039028 c.1677G>A synonymous_variant 0.93 pyrazinamide
clpC1 4039070 c.1635G>C synonymous_variant 0.92 pyrazinamide
clpC1 4039073 c.1632C>G synonymous_variant 0.92 pyrazinamide
clpC1 4040048 c.657C>T synonymous_variant 0.91 pyrazinamide Not assoc w R - Interim
clpC1 4040057 c.648C>T synonymous_variant 0.92 pyrazinamide
clpC1 4040090 c.613_615delTCTinsAGC synonymous_variant 0.96 pyrazinamide
clpC1 4040093 c.610_612delCTCinsTG frameshift_variant&synonymous_variant 0.96 pyrazinamide
clpC1 4040138 c.567G>C synonymous_variant 0.97 pyrazinamide
clpC1 4040144 c.561G>C synonymous_variant 0.97 pyrazinamide
clpC1 4040147 c.558A>G synonymous_variant 0.97 pyrazinamide Not assoc w R - Interim
clpC1 4040153 c.552A>G synonymous_variant 0.97 pyrazinamide
clpC1 4040159 c.546G>C synonymous_variant 0.97 pyrazinamide
clpC1 4040162 c.543G>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4040168 c.537G>C synonymous_variant 1.0 pyrazinamide
clpC1 4040171 c.534C>G synonymous_variant 1.0 pyrazinamide
clpC1 4040180 c.525C>T synonymous_variant 1.0 pyrazinamide
clpC1 4040200 c.505T>C synonymous_variant 1.0 pyrazinamide
clpC1 4040201 c.504C>G synonymous_variant 1.0 pyrazinamide
clpC1 4040204 c.501G>C synonymous_variant 1.0 pyrazinamide
clpC1 4040207 c.498T>C synonymous_variant 1.0 pyrazinamide
clpC1 4040213 c.492T>A synonymous_variant 1.0 pyrazinamide
clpC1 4040225 c.480A>T synonymous_variant 1.0 pyrazinamide
clpC1 4040228 c.477G>C synonymous_variant 1.0 pyrazinamide
clpC1 4040231 c.474C>G synonymous_variant 1.0 pyrazinamide
clpC1 4040234 c.471C>A synonymous_variant 1.0 pyrazinamide
clpC1 4040237 c.468C>G synonymous_variant 1.0 pyrazinamide
clpC1 4040249 c.456A>G synonymous_variant 1.0 pyrazinamide
clpC1 4040252 c.453C>G synonymous_variant 1.0 pyrazinamide
clpC1 4040257 p.Ala150Thr missense_variant 1.0 pyrazinamide
clpC1 4040267 c.438A>G synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
glpK 4138514 c.1242A>C synonymous_variant 0.7 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138523 c.1233C>G synonymous_variant 0.67 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138526 p.Asp410Glu missense_variant 0.67 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138529 p.Val409Ala missense_variant 0.67 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138565 c.1191G>C synonymous_variant 0.87 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138568 c.1188A>C synonymous_variant 0.87 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138571 c.1185C>G synonymous_variant 0.87 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138574 c.1182G>C synonymous_variant 0.87 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138580 c.1176C>T synonymous_variant 0.87 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138583 c.1173G>A synonymous_variant 0.87 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138598 c.1158G>C synonymous_variant 0.86 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138610 c.1146C>G synonymous_variant 0.85 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138625 c.1131G>C synonymous_variant 0.88 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138631 c.1125C>G synonymous_variant 0.92 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138634 c.1122G>T synonymous_variant 0.92 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138643 c.1113A>G synonymous_variant 0.93 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4138654 c.1102C>T synonymous_variant 0.93 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4138655 c.1101G>C synonymous_variant 0.93 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138676 c.1080T>C synonymous_variant 0.92 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138682 c.1074C>G synonymous_variant 0.9 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138696 p.Pro354Ser missense_variant 0.86 ethambutol Uncertain significance
moxifloxacin
streptomycin
levofloxacin
rifampicin Uncertain significance
isoniazid Uncertain significance
embB 4248001 c.1488C>T synonymous_variant 0.9 ethambutol Not assoc w R - Interim