Run ID: SRR29097058
Sample name:
Date: 2025-02-11T11:39:31.566307
Number of reads: 105963
Percentage reads mapped: 34.43
Median coverage: 0.0
Strain: lineage4.9
Spoligotype:
Drug-resistance: Other
| Lineage | Family | RDs | Frequency |
|---|---|---|---|
| lineage4 | Euro-American | None | 1.0 |
| lineage4.9 | Euro-American (H37Rv-like) | None | 1.0 |
| Drug | Resistance | Supporting mutations | WHO confidence | Comment |
|---|---|---|---|---|
| rifampicin | ||||
| isoniazid | ||||
| ethambutol | embB | p.Leu359Ile | Uncertain significance | Mutation from literature |
| pyrazinamide | ||||
| streptomycin | ||||
| fluoroquinolones | ||||
| moxifloxacin | ||||
| ofloxacin | ||||
| levofloxacin | ||||
| ciprofloxacin | ||||
| aminoglycosides | ||||
| amikacin | ||||
| capreomycin | ||||
| kanamycin | ||||
| cycloserine | ||||
| ethionamide | ||||
| clofazimine | ||||
| para-aminosalicylic_acid | ||||
| delamanid | ||||
| bedaquiline | ||||
| linezolid |
| Gene | Chromosome position | Mutation | Type | Estimated fraction | Drugs | Confidence | Comment |
|---|---|---|---|---|---|---|---|
| embB | 4247588 | p.Leu359Ile | missense_variant | 1.0 | ethambutol | Uncertain significance | Mutation from literature |
| Gene | Chromosome position | Mutation | Type | Estimated fraction | Drugs | Confidence |
|---|---|---|---|---|---|---|
| dnaA | 714 | c.714C>G | synonymous_variant | 1.0 | isoniazid | Not assoc w R - Interim |
| dnaA | 741 | c.741T>C | synonymous_variant | 1.0 | isoniazid | Not assoc w R - Interim |
| dnaA | 750 | c.750C>G | synonymous_variant | 1.0 | isoniazid | |
| dnaA | 756 | c.756T>C | synonymous_variant | 1.0 | isoniazid | |
| dnaA | 822 | c.822A>G | synonymous_variant | 1.0 | isoniazid | |
| dnaA | 828 | c.828T>C | synonymous_variant | 1.0 | isoniazid | Not assoc w R - Interim |
| dnaA | 831 | c.831A>G | synonymous_variant | 1.0 | isoniazid | |
| dnaA | 837 | c.837A>G | synonymous_variant | 1.0 | isoniazid | |
| dnaA | 840 | c.840G>A | synonymous_variant | 1.0 | isoniazid | |
| dnaA | 846 | c.846T>C | synonymous_variant | 1.0 | isoniazid | |
| dnaA | 849 | c.849A>G | synonymous_variant | 1.0 | isoniazid | |
| dnaA | 852 | c.852G>A | synonymous_variant | 1.0 | isoniazid | Not assoc w R - Interim |
| dnaA | 864 | c.864C>T | synonymous_variant | 1.0 | isoniazid | |
| dnaA | 876 | c.876C>G | synonymous_variant | 1.0 | isoniazid | |
| dnaA | 877 | c.877T>C | synonymous_variant | 1.0 | isoniazid | |
| dnaA | 885 | c.885T>C | synonymous_variant | 1.0 | isoniazid | |
| dnaA | 897 | c.897A>G | synonymous_variant | 1.0 | isoniazid | |
| dnaA | 903 | c.903C>G | synonymous_variant | 1.0 | isoniazid | Not assoc w R - Interim |
| dnaA | 909 | c.909A>C | synonymous_variant | 1.0 | isoniazid | Not assoc w R - Interim |
| dnaA | 912 | c.912T>G | synonymous_variant | 1.0 | isoniazid | |
| dnaA | 918 | c.918C>G | synonymous_variant | 1.0 | isoniazid | |
| dnaA | 921 | c.921A>G | synonymous_variant | 1.0 | isoniazid | Not assoc w R - Interim |
| dnaA | 927 | c.927G>A | synonymous_variant | 1.0 | isoniazid | |
| dnaA | 933 | c.933C>G | synonymous_variant | 1.0 | isoniazid | |
| dnaA | 955 | c.955_957delAGAinsCGG | synonymous_variant | 1.0 | isoniazid | |
| dnaA | 963 | c.963C>G | synonymous_variant | 1.0 | isoniazid | |
| dnaA | 966 | c.966T>C | synonymous_variant | 1.0 | isoniazid | |
| dnaA | 984 | c.984T>C | synonymous_variant | 1.0 | isoniazid | Not assoc w R - Interim |
| dnaA | 990 | c.990A>C | synonymous_variant | 1.0 | isoniazid | |
| dnaA | 993 | c.993A>G | synonymous_variant | 1.0 | isoniazid | |
| dnaA | 996 | c.996A>G | synonymous_variant | 1.0 | isoniazid | |
| dnaA | 1014 | c.1014C>G | synonymous_variant | 0.94 | isoniazid | |
| dnaA | 1020 | c.1020C>G | synonymous_variant | 0.94 | isoniazid | |
| dnaA | 1024 | c.1024T>C | synonymous_variant | 1.0 | isoniazid | |
| gyrA | 6565 | c.-737G>C | upstream_gene_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| gyrA | 6583 | c.-719G>C | upstream_gene_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| gyrB | 6590 | p.Arg451Ser | missense_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| gyrA | 6598 | c.-704C>G | upstream_gene_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| gyrA | 6610 | c.-692C>G | upstream_gene_variant | 0.97 | levofloxacin | |
| moxifloxacin | ||||||
| gyrA | 6613 | c.-689A>G | upstream_gene_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| gyrA | 6616 | c.-686A>G | upstream_gene_variant | 0.97 | levofloxacin | |
| moxifloxacin | ||||||
| gyrA | 6622 | c.-680C>T | upstream_gene_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| gyrA | 6637 | c.-665T>G | upstream_gene_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| gyrA | 6649 | c.-653T>C | upstream_gene_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| gyrA | 6652 | c.-650C>G | upstream_gene_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| gyrA | 6673 | c.-629A>T | upstream_gene_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| gyrA | 6676 | c.-626T>G | upstream_gene_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| gyrB | 6680 | c.1441C>T | synonymous_variant | 0.87 | levofloxacin | Not assoc w R - Interim |
| moxifloxacin | Not assoc w R - Interim | |||||
| gyrA | 6703 | c.-599G>C | upstream_gene_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| gyrA | 6709 | c.-593A>G | upstream_gene_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| gyrA | 6712 | c.-590G>C | upstream_gene_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| gyrA | 6727 | c.-575G>T | upstream_gene_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| gyrA | 6728 | c.-574_-572delCTAinsTTG | upstream_gene_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| gyrB | 6745 | c.1506T>C | synonymous_variant | 1.0 | levofloxacin | Not assoc w R - Interim |
| moxifloxacin | Not assoc w R - Interim | |||||
| gyrA | 6751 | c.-551G>C | upstream_gene_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| gyrA | 6760 | c.-542G>C | upstream_gene_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| gyrA | 6775 | c.-527G>T | upstream_gene_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| gyrA | 6787 | c.-515G>A | upstream_gene_variant | 0.5 | levofloxacin | |
| moxifloxacin | ||||||
| gyrB | 6793 | c.1554T>C | synonymous_variant | 1.0 | levofloxacin | Not assoc w R - Interim |
| moxifloxacin | Not assoc w R - Interim | |||||
| gyrB | 6797 | p.Gly520Ser | missense_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| gyrB | 6808 | c.1569C>G | synonymous_variant | 1.0 | levofloxacin | Not assoc w R - Interim |
| moxifloxacin | Not assoc w R - Interim | |||||
| gyrB | 6811 | c.1572C>T | synonymous_variant | 1.0 | levofloxacin | |
| moxifloxacin | Not assoc w R - Interim | |||||
| gyrA | 8372 | c.1071G>C | synonymous_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| gyrA | 8382 | p.Leu361Met | missense_variant | 0.91 | levofloxacin | |
| moxifloxacin | ||||||
| gyrA | 8393 | c.1092T>C | synonymous_variant | 1.0 | levofloxacin | Not assoc w R - Interim |
| moxifloxacin | Not assoc w R - Interim | |||||
| gyrA | 8399 | c.1098T>C | synonymous_variant | 0.92 | levofloxacin | Not assoc w R - Interim |
| moxifloxacin | Not assoc w R - Interim | |||||
| gyrA | 8401 | p.Asp367Ala | missense_variant | 0.92 | levofloxacin | |
| moxifloxacin | ||||||
| gyrA | 8417 | c.1116C>G | synonymous_variant | 0.92 | levofloxacin | |
| moxifloxacin | ||||||
| gyrA | 8420 | c.1119T>C | synonymous_variant | 0.92 | levofloxacin | |
| moxifloxacin | ||||||
| gyrA | 8421 | p.Val374Ile | missense_variant | 0.92 | levofloxacin | |
| moxifloxacin | ||||||
| gyrA | 8426 | c.1125G>C | synonymous_variant | 0.92 | levofloxacin | |
| moxifloxacin | ||||||
| gyrA | 8429 | c.1128C>G | synonymous_variant | 0.92 | levofloxacin | |
| moxifloxacin | ||||||
| gyrA | 8453 | c.1152A>C | synonymous_variant | 0.94 | levofloxacin | |
| moxifloxacin | ||||||
| gyrA | 8462 | c.1161A>G | synonymous_variant | 0.94 | levofloxacin | |
| moxifloxacin | ||||||
| gyrA | 8471 | c.1170T>C | synonymous_variant | 0.94 | levofloxacin | |
| moxifloxacin | ||||||
| gyrA | 8480 | c.1179C>T | synonymous_variant | 0.93 | levofloxacin | |
| moxifloxacin | ||||||
| gyrA | 8486 | c.1185T>C | synonymous_variant | 0.93 | levofloxacin | Not assoc w R - Interim |
| moxifloxacin | Not assoc w R - Interim | |||||
| gyrA | 8489 | c.1188A>G | synonymous_variant | 0.93 | levofloxacin | |
| moxifloxacin | ||||||
| gyrA | 8501 | c.1200G>C | synonymous_variant | 0.93 | levofloxacin | Not assoc w R - Interim |
| moxifloxacin | Not assoc w R - Interim | |||||
| gyrA | 8504 | c.1203G>C | synonymous_variant | 0.93 | levofloxacin | |
| moxifloxacin | ||||||
| gyrA | 8513 | c.1212C>G | synonymous_variant | 0.92 | levofloxacin | Not assoc w R - Interim |
| moxifloxacin | Not assoc w R - Interim | |||||
| gyrA | 8516 | c.1215T>C | synonymous_variant | 0.9 | levofloxacin | |
| moxifloxacin | ||||||
| gyrA | 8519 | c.1218A>G | synonymous_variant | 0.9 | levofloxacin | Not assoc w R - Interim |
| moxifloxacin | Not assoc w R - Interim | |||||
| gyrA | 8520 | c.1219C>T | synonymous_variant | 0.9 | levofloxacin | |
| moxifloxacin | ||||||
| gyrA | 8531 | c.1230G>C | synonymous_variant | 0.9 | levofloxacin | |
| moxifloxacin | ||||||
| gyrA | 8546 | c.1245T>C | synonymous_variant | 0.9 | levofloxacin | Not assoc w R - Interim |
| moxifloxacin | Not assoc w R - Interim | |||||
| gyrA | 8561 | c.1260A>C | synonymous_variant | 1.0 | levofloxacin | Not assoc w R - Interim |
| moxifloxacin | Not assoc w R - Interim | |||||
| gyrA | 8711 | c.1410A>C | synonymous_variant | 0.9 | levofloxacin | |
| moxifloxacin | ||||||
| gyrA | 8714 | c.1413A>G | synonymous_variant | 0.9 | levofloxacin | |
| moxifloxacin | ||||||
| gyrA | 8717 | c.1416C>G | synonymous_variant | 0.9 | levofloxacin | Not assoc w R - Interim |
| moxifloxacin | Not assoc w R - Interim | |||||
| gyrA | 8723 | c.1422G>T | synonymous_variant | 0.9 | levofloxacin | |
| moxifloxacin | Not assoc w R - Interim | |||||
| gyrA | 8731 | p.Gly477Ala | missense_variant | 0.9 | levofloxacin | |
| moxifloxacin | ||||||
| gyrA | 8738 | c.1437G>C | synonymous_variant | 0.92 | levofloxacin | |
| moxifloxacin | ||||||
| gyrA | 8747 | c.1446A>G | synonymous_variant | 0.92 | levofloxacin | |
| moxifloxacin | ||||||
| gyrA | 8750 | c.1449C>G | synonymous_variant | 0.92 | levofloxacin | |
| moxifloxacin | ||||||
| gyrA | 8756 | c.1455A>G | synonymous_variant | 0.93 | levofloxacin | Not assoc w R - Interim |
| moxifloxacin | Not assoc w R - Interim | |||||
| gyrA | 8762 | c.1461G>C | synonymous_variant | 0.93 | levofloxacin | Not assoc w R - Interim |
| moxifloxacin | Not assoc w R - Interim | |||||
| gyrA | 8765 | p.Asp488Glu | missense_variant | 0.93 | levofloxacin | Uncertain significance |
| moxifloxacin | Uncertain significance | |||||
| gyrA | 8767 | p.Arg489Lys | missense_variant | 0.94 | levofloxacin | Uncertain significance |
| moxifloxacin | Uncertain significance | |||||
| gyrA | 8783 | c.1482G>T | synonymous_variant | 0.96 | levofloxacin | |
| moxifloxacin | ||||||
| gyrA | 8796 | p.Ile499Val | missense_variant | 0.96 | levofloxacin | |
| moxifloxacin | ||||||
| gyrA | 8799 | p.Ala500Pro | missense_variant | 0.96 | levofloxacin | |
| moxifloxacin | ||||||
| gyrA | 8810 | c.1509A>C | synonymous_variant | 0.96 | levofloxacin | |
| moxifloxacin | ||||||
| gyrA | 8813 | p.Asp504Glu | missense_variant | 0.96 | levofloxacin | Uncertain significance |
| moxifloxacin | Uncertain significance | |||||
| gyrA | 8825 | c.1524G>A | synonymous_variant | 0.96 | levofloxacin | |
| moxifloxacin | ||||||
| gyrA | 8828 | c.1527T>C | synonymous_variant | 0.96 | levofloxacin | |
| moxifloxacin | ||||||
| gyrA | 8829 | c.1528T>C | synonymous_variant | 0.96 | levofloxacin | Not assoc w R - Interim |
| moxifloxacin | Not assoc w R - Interim | |||||
| gyrA | 8852 | c.1551T>C | synonymous_variant | 0.97 | levofloxacin | |
| moxifloxacin | ||||||
| gyrA | 8858 | c.1557T>C | synonymous_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| gyrA | 8867 | c.1566A>G | synonymous_variant | 1.0 | levofloxacin | Not assoc w R - Interim |
| moxifloxacin | Not assoc w R - Interim | |||||
| gyrA | 8870 | c.1569G>C | synonymous_variant | 1.0 | levofloxacin | Not assoc w R - Interim |
| moxifloxacin | Not assoc w R - Interim | |||||
| gyrA | 8873 | c.1572A>C | synonymous_variant | 0.97 | levofloxacin | Not assoc w R - Interim |
| moxifloxacin | Not assoc w R - Interim | |||||
| gyrA | 8885 | c.1584C>G | synonymous_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| gyrA | 8903 | c.1602T>C | synonymous_variant | 1.0 | levofloxacin | Not assoc w R - Interim |
| moxifloxacin | Not assoc w R - Interim | |||||
| gyrA | 8939 | c.1638T>C | synonymous_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| gyrA | 8945 | c.1644G>C | synonymous_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| gyrA | 8946 | c.1645_1647delTTGinsCTC | synonymous_variant | 1.0 | levofloxacin | Not assoc w R - Interim |
| moxifloxacin | Not assoc w R - Interim | |||||
| gyrA | 8967 | p.Ala556Asn | missense_variant | 0.97 | levofloxacin | |
| moxifloxacin | ||||||
| gyrA | 8981 | c.1680G>C | synonymous_variant | 1.0 | levofloxacin | Not assoc w R - Interim |
| moxifloxacin | Not assoc w R - Interim | |||||
| gyrA | 8990 | c.1689C>G | synonymous_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| gyrA | 8993 | c.1692C>T | synonymous_variant | 1.0 | levofloxacin | Not assoc w R - Interim |
| moxifloxacin | Not assoc w R - Interim | |||||
| gyrA | 8996 | c.1695T>C | synonymous_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| gyrA | 8998 | p.Leu566Trp | missense_variant | 1.0 | levofloxacin | Uncertain significance |
| moxifloxacin | Uncertain significance | |||||
| gyrA | 9017 | c.1716C>G | synonymous_variant | 1.0 | levofloxacin | Not assoc w R - Interim |
| moxifloxacin | Not assoc w R - Interim | |||||
| gyrA | 9023 | c.1722A>C | synonymous_variant | 1.0 | levofloxacin | Not assoc w R - Interim |
| moxifloxacin | Not assoc w R - Interim | |||||
| gyrA | 9029 | c.1728T>C | synonymous_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| gyrA | 9032 | c.1731T>C | synonymous_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| gyrA | 9044 | c.1743C>A | synonymous_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| ccsA | 620319 | c.429C>G | synonymous_variant | 1.0 | kanamycin | |
| capreomycin | ||||||
| amikacin | ||||||
| ccsA | 620337 | c.447C>G | synonymous_variant | 1.0 | kanamycin | |
| capreomycin | ||||||
| amikacin | ||||||
| ccsA | 620340 | c.450C>G | synonymous_variant | 1.0 | kanamycin | |
| capreomycin | ||||||
| amikacin | ||||||
| ccsA | 620343 | c.453G>C | synonymous_variant | 1.0 | kanamycin | |
| capreomycin | ||||||
| amikacin | ||||||
| ccsA | 620346 | c.456C>G | synonymous_variant | 1.0 | kanamycin | |
| capreomycin | ||||||
| amikacin | ||||||
| ccsA | 620349 | c.459A>G | synonymous_variant | 1.0 | kanamycin | |
| capreomycin | ||||||
| amikacin | ||||||
| ccsA | 620352 | c.462C>T | synonymous_variant | 1.0 | kanamycin | |
| capreomycin | ||||||
| amikacin | ||||||
| ccsA | 620358 | c.468C>G | synonymous_variant | 1.0 | kanamycin | |
| capreomycin | ||||||
| amikacin | ||||||
| ccsA | 620362 | p.Ala158Ser | missense_variant | 1.0 | kanamycin | |
| capreomycin | ||||||
| amikacin | ||||||
| ccsA | 620367 | c.477T>C | synonymous_variant | 1.0 | kanamycin | |
| capreomycin | ||||||
| amikacin | ||||||
| ccsA | 620385 | c.495G>C | synonymous_variant | 1.0 | kanamycin | |
| capreomycin | ||||||
| amikacin | ||||||
| ccsA | 620388 | c.498A>G | synonymous_variant | 1.0 | kanamycin | |
| capreomycin | ||||||
| amikacin | ||||||
| ccsA | 620412 | c.522T>C | synonymous_variant | 1.0 | kanamycin | |
| capreomycin | ||||||
| amikacin | ||||||
| ccsA | 620415 | c.525T>C | synonymous_variant | 1.0 | kanamycin | Not assoc w R - Interim |
| capreomycin | Not assoc w R - Interim | |||||
| amikacin | Not assoc w R - Interim | |||||
| ccsA | 620439 | c.549T>C | synonymous_variant | 1.0 | kanamycin | |
| capreomycin | ||||||
| amikacin | ||||||
| ccsA | 620445 | c.555A>G | synonymous_variant | 1.0 | kanamycin | |
| capreomycin | ||||||
| amikacin | ||||||
| ccsA | 620613 | c.723C>T | synonymous_variant | 0.82 | kanamycin | |
| capreomycin | ||||||
| amikacin | ||||||
| ccsA | 620625 | c.735A>C | synonymous_variant | 0.88 | kanamycin | |
| capreomycin | ||||||
| amikacin | ||||||
| ccsA | 620631 | c.741T>C | synonymous_variant | 0.88 | kanamycin | |
| capreomycin | ||||||
| amikacin | ||||||
| ccsA | 620634 | c.744C>G | synonymous_variant | 0.89 | kanamycin | |
| capreomycin | ||||||
| amikacin | ||||||
| ccsA | 620649 | c.759A>G | synonymous_variant | 0.95 | kanamycin | |
| capreomycin | ||||||
| amikacin | ||||||
| ccsA | 620661 | c.771C>G | synonymous_variant | 0.96 | kanamycin | |
| capreomycin | ||||||
| amikacin | ||||||
| ccsA | 620670 | c.780C>T | synonymous_variant | 0.96 | kanamycin | |
| capreomycin | ||||||
| amikacin | ||||||
| ccsA | 620685 | c.795G>A | synonymous_variant | 0.96 | kanamycin | Not assoc w R - Interim |
| capreomycin | Not assoc w R - Interim | |||||
| amikacin | ||||||
| ccsA | 620688 | c.798G>C | synonymous_variant | 0.96 | kanamycin | |
| capreomycin | ||||||
| amikacin | ||||||
| ccsA | 620691 | c.801G>C | synonymous_variant | 0.92 | kanamycin | |
| capreomycin | ||||||
| amikacin | ||||||
| ccsA | 620694 | c.804C>G | synonymous_variant | 0.96 | kanamycin | |
| capreomycin | ||||||
| amikacin | ||||||
| ccsA | 620698 | p.Val270Ile | missense_variant | 0.96 | kanamycin | |
| capreomycin | ||||||
| amikacin | ||||||
| ccsA | 620703 | c.813G>C | synonymous_variant | 0.96 | kanamycin | |
| capreomycin | ||||||
| amikacin | ||||||
| ccsA | 620724 | c.834C>T | synonymous_variant | 0.96 | kanamycin | |
| capreomycin | ||||||
| amikacin | ||||||
| ccsA | 620736 | c.846G>T | synonymous_variant | 0.95 | kanamycin | |
| capreomycin | ||||||
| amikacin | ||||||
| ccsA | 620739 | c.849A>G | synonymous_variant | 0.95 | kanamycin | |
| capreomycin | ||||||
| amikacin | ||||||
| ccsA | 620742 | c.852G>C | synonymous_variant | 1.0 | kanamycin | |
| capreomycin | ||||||
| amikacin | ||||||
| ccsA | 620766 | c.876C>G | synonymous_variant | 1.0 | kanamycin | |
| capreomycin | ||||||
| amikacin | ||||||
| ccsA | 620778 | c.888T>C | synonymous_variant | 1.0 | kanamycin | |
| capreomycin | ||||||
| amikacin | ||||||
| ccsA | 620783 | p.Ala298Val | missense_variant | 1.0 | kanamycin | |
| capreomycin | ||||||
| amikacin | ||||||
| nusG | 734421 | c.168A>C | synonymous_variant | 1.0 | rifampicin | |
| nusG | 734424 | c.171G>C | synonymous_variant | 1.0 | rifampicin | |
| nusG | 734439 | c.186C>G | synonymous_variant | 1.0 | rifampicin | |
| nusG | 734442 | c.189G>A | synonymous_variant | 1.0 | rifampicin | |
| nusG | 734451 | c.198G>C | synonymous_variant | 1.0 | rifampicin | |
| nusG | 734454 | c.201A>G | synonymous_variant | 1.0 | rifampicin | |
| nusG | 734460 | c.207G>C | synonymous_variant | 1.0 | rifampicin | |
| nusG | 734472 | c.219T>G | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| nusG | 734475 | c.222T>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| nusG | 734499 | c.246G>C | synonymous_variant | 1.0 | rifampicin | |
| nusG | 734532 | c.279A>G | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| nusG | 734541 | c.288A>G | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoB | 760112 | c.306T>C | synonymous_variant | 1.0 | rifampicin | |
| rpoB | 760118 | c.312T>G | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoB | 760121 | c.315T>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoB | 760130 | p.Asp108Glu | missense_variant | 1.0 | rifampicin | Uncertain significance |
| rpoB | 760139 | c.333A>T | synonymous_variant | 1.0 | rifampicin | |
| rpoB | 760142 | c.336C>G | synonymous_variant | 1.0 | rifampicin | |
| rpoB | 760181 | c.375T>C | synonymous_variant | 0.95 | rifampicin | Not assoc w R - Interim |
| rpoB | 760184 | c.378A>G | synonymous_variant | 0.95 | rifampicin | Not assoc w R - Interim |
| rpoB | 760196 | c.390C>G | synonymous_variant | 0.95 | rifampicin | Not assoc w R - Interim |
| rpoB | 760235 | c.429T>C | synonymous_variant | 0.92 | rifampicin | Not assoc w R - Interim |
| rpoB | 760244 | c.438G>C | synonymous_variant | 0.93 | rifampicin | Not assoc w R - Interim |
| rpoB | 760793 | c.987A>G | synonymous_variant | 1.0 | rifampicin | |
| rpoB | 760805 | c.999G>C | synonymous_variant | 1.0 | rifampicin | |
| rpoB | 760808 | c.1002C>G | synonymous_variant | 1.0 | rifampicin | |
| rpoB | 761180 | c.1374A>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoB | 761189 | c.1383T>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoB | 761195 | c.1389G>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoB | 761198 | c.1392G>T | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoB | 761217 | p.Pro471Ala | missense_variant | 1.0 | rifampicin | |
| rpoB | 761220 | c.1414_1416delTCGinsAGC | synonymous_variant | 1.0 | rifampicin | |
| rpoB | 761234 | c.1428G>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoB | 761249 | c.1443A>G | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoB | 761645 | c.1839C>G | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoB | 761648 | c.1842T>C | synonymous_variant | 1.0 | rifampicin | |
| rpoB | 761666 | c.1860G>C | synonymous_variant | 1.0 | rifampicin | |
| rpoB | 761669 | c.1863C>T | synonymous_variant | 1.0 | rifampicin | |
| rpoB | 761675 | c.1869G>C | synonymous_variant | 1.0 | rifampicin | |
| rpoB | 761690 | c.1884G>C | synonymous_variant | 1.0 | rifampicin | |
| rpoB | 761712 | p.Val636Ile | missense_variant | 1.0 | rifampicin | |
| rpoB | 761718 | c.1912_1913delGCinsT | frameshift_variant&missense_variant | 1.0 | rifampicin | |
| rpoB | 761722 | p.Glu639Gly | missense_variant | 1.0 | rifampicin | Uncertain significance |
| rpoB | 761727 | p.Ser641Val | missense_variant | 1.0 | rifampicin | |
| rpoB | 761729 | c.1925dupG | frameshift_variant | 1.0 | rifampicin | |
| rpoB | 761736 | p.Ile644Val | missense_variant | 1.0 | rifampicin | Uncertain significance |
| rpoB | 761747 | c.1941G>C | synonymous_variant | 1.0 | rifampicin | |
| rpoB | 761765 | c.1959T>C | synonymous_variant | 1.0 | rifampicin | |
| rpoB | 761772 | p.His656Ala | missense_variant | 1.0 | rifampicin | |
| rpoB | 761778 | p.Asn658Asp | missense_variant | 1.0 | rifampicin | |
| rpoC | 763699 | c.330G>C | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 763702 | c.333C>G | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoC | 763709 | c.340C>T | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 763714 | c.345G>C | synonymous_variant | 0.92 | rifampicin | Not assoc w R - Interim |
| rpoC | 763717 | c.348T>C | synonymous_variant | 0.92 | rifampicin | Not assoc w R - Interim |
| rpoC | 763723 | c.354G>C | synonymous_variant | 0.92 | rifampicin | |
| rpoC | 763741 | c.372C>T | synonymous_variant | 0.92 | rifampicin | |
| rpoC | 763747 | c.378G>A | synonymous_variant | 0.92 | rifampicin | |
| rpoC | 763765 | c.396T>G | synonymous_variant | 0.92 | rifampicin | Not assoc w R - Interim |
| rpoC | 763792 | p.Glu141Asp | missense_variant | 0.92 | rifampicin | |
| rpoC | 763807 | c.438T>C | synonymous_variant | 0.92 | rifampicin | Not assoc w R - Interim |
| rpoC | 763813 | c.444C>G | synonymous_variant | 0.92 | rifampicin | |
| rpoC | 763816 | c.447C>G | synonymous_variant | 0.92 | rifampicin | |
| rpoC | 763872 | p.Gly168Ala | missense_variant | 1.0 | rifampicin | |
| rpoC | 763876 | p.Glu169Asp | missense_variant | 1.0 | rifampicin | |
| rpoC | 763879 | c.510A>G | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 763891 | c.522G>C | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 763894 | c.525A>G | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 763900 | c.531G>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoC | 763921 | c.552G>C | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 763924 | c.555G>A | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 763940 | p.Ala191Ser | missense_variant | 1.0 | rifampicin | Uncertain significance |
| rpoC | 763945 | c.576T>C | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 763947 | p.Ala193Val | missense_variant | 1.0 | rifampicin | Uncertain significance |
| rpoC | 763951 | c.582G>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoC | 763960 | c.591T>G | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoC | 763978 | c.609C>G | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 763987 | c.618C>T | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 763991 | p.Ile208Leu | missense_variant | 1.0 | rifampicin | |
| rpoC | 763996 | c.627T>C | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 764002 | c.633C>G | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 764005 | c.636G>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoC | 766651 | c.3282T>C | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 766658 | p.Arg1097Gly | missense_variant | 1.0 | rifampicin | |
| rpoC | 766666 | c.3297C>G | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 766672 | c.3303T>C | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 766675 | c.3306C>T | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 766681 | c.3312C>T | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 766690 | c.3321G>C | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 766694 | p.Gln1109Asp | missense_variant | 1.0 | rifampicin | |
| rpoC | 766714 | c.3345G>C | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 766717 | c.3348C>A | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 766726 | c.3357T>C | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 766738 | c.3369G>T | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 766741 | c.3372G>C | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 767059 | c.3690T>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoC | 767098 | c.3729T>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoC | 767104 | c.3735C>G | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoC | 767105 | p.Asn1246Gln | missense_variant | 1.0 | rifampicin | Uncertain significance |
| rpoC | 767180 | p.Ala1271Gln | missense_variant | 1.0 | rifampicin | |
| rpoC | 767197 | c.3828G>A | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoC | 767221 | c.3852C>G | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoC | 767230 | c.3861G>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoC | 767233 | c.3864T>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| mmpL5 | 775814 | c.2667C>A | synonymous_variant | 0.56 | bedaquiline | |
| clofazimine | ||||||
| mmpL5 | 775817 | c.2664T>C | synonymous_variant | 1.0 | bedaquiline | Not assoc w R - Interim |
| clofazimine | Not assoc w R - Interim | |||||
| mmpL5 | 775826 | c.2655G>C | synonymous_variant | 0.88 | bedaquiline | |
| clofazimine | ||||||
| mmpL5 | 775829 | c.2652C>G | synonymous_variant | 0.39 | bedaquiline | |
| clofazimine | ||||||
| mmpL5 | 775832 | p.Ala883Ser | missense_variant | 0.35 | bedaquiline | |
| clofazimine | ||||||
| mmpL5 | 775835 | c.2646C>G | synonymous_variant | 0.47 | bedaquiline | |
| clofazimine | ||||||
| mmpL5 | 775847 | c.2634G>C | synonymous_variant | 0.48 | bedaquiline | |
| clofazimine | ||||||
| mmpL5 | 775850 | p.Ser877Thr | missense_variant | 0.51 | bedaquiline | |
| clofazimine | ||||||
| mmpL5 | 775856 | c.2625T>C | synonymous_variant | 0.45 | bedaquiline | |
| clofazimine | ||||||
| mmpL5 | 775862 | c.2619G>C | synonymous_variant | 1.0 | bedaquiline | |
| clofazimine | ||||||
| mmpL5 | 775865 | c.2616T>G | synonymous_variant | 1.0 | bedaquiline | |
| clofazimine | ||||||
| mmpL5 | 775885 | p.Ile866Leu | missense_variant | 0.79 | bedaquiline | |
| clofazimine | ||||||
| mmpL5 | 775886 | c.2595A>G | synonymous_variant | 1.0 | bedaquiline | |
| clofazimine | ||||||
| mmpL5 | 775889 | c.2592C>G | synonymous_variant | 0.8 | bedaquiline | |
| clofazimine | ||||||
| mmpL5 | 775909 | p.Leu858Ile | missense_variant | 0.39 | bedaquiline | |
| clofazimine | ||||||
| mmpL5 | 775910 | c.2571G>A | synonymous_variant | 0.45 | bedaquiline | |
| clofazimine | ||||||
| mmpL5 | 775915 | p.Ala856Ser | missense_variant | 0.9 | bedaquiline | |
| clofazimine | ||||||
| mmpL5 | 775916 | c.2565T>C | synonymous_variant | 1.0 | bedaquiline | |
| clofazimine | ||||||
| mmpL5 | 775921 | c.2560C>T | synonymous_variant | 0.73 | bedaquiline | |
| clofazimine | ||||||
| mmpL5 | 775940 | c.2541C>T | synonymous_variant | 0.78 | bedaquiline | |
| clofazimine | ||||||
| mmpL5 | 775943 | c.2538C>G | synonymous_variant | 0.7 | bedaquiline | |
| clofazimine | ||||||
| mmpL5 | 775951 | c.2530C>T | synonymous_variant | 0.82 | bedaquiline | |
| clofazimine | ||||||
| mmpL5 | 775961 | c.2520C>G | synonymous_variant | 0.94 | bedaquiline | |
| clofazimine | ||||||
| mmpL5 | 775966 | p.Ala839Ser | missense_variant | 0.83 | bedaquiline | |
| clofazimine | ||||||
| mmpL5 | 775970 | c.2511G>C | synonymous_variant | 0.75 | bedaquiline | |
| clofazimine | ||||||
| mmpL5 | 775975 | c.2506T>C | synonymous_variant | 1.0 | bedaquiline | |
| clofazimine | ||||||
| mmpL5 | 775981 | p.Leu834Met | missense_variant | 1.0 | bedaquiline | |
| clofazimine | ||||||
| mmpL5 | 775987 | p.His832Asn | missense_variant | 0.38 | bedaquiline | |
| clofazimine | ||||||
| mmpL5 | 775991 | p.Glu830Gln | missense_variant | 0.79 | bedaquiline | |
| clofazimine | ||||||
| mmpL5 | 775997 | c.2484T>G | synonymous_variant | 0.83 | bedaquiline | |
| clofazimine | ||||||
| mmpL5 | 776000 | p.Leu827Ile | missense_variant | 1.0 | bedaquiline | |
| clofazimine | ||||||
| mmpL5 | 776009 | c.2472A>G | synonymous_variant | 1.0 | bedaquiline | |
| clofazimine | ||||||
| mmpL5 | 776030 | c.2451G>C | synonymous_variant | 0.58 | bedaquiline | |
| clofazimine | ||||||
| rplC | 800633 | c.-176T>C | upstream_gene_variant | 1.0 | linezolid | |
| fbiC | 1304559 | p.Glu543Asp | missense_variant | 1.0 | pretomanid | |
| delamanid | ||||||
| clofazimine | ||||||
| fbiC | 1304565 | c.1635C>G | synonymous_variant | 1.0 | pretomanid | |
| delamanid | ||||||
| clofazimine | ||||||
| fbiC | 1304568 | c.1638T>C | synonymous_variant | 1.0 | pretomanid | |
| delamanid | ||||||
| clofazimine | ||||||
| fbiC | 1304571 | c.1641G>C | synonymous_variant | 1.0 | pretomanid | |
| delamanid | ||||||
| clofazimine | ||||||
| fbiC | 1304580 | c.1650T>C | synonymous_variant | 1.0 | pretomanid | |
| delamanid | ||||||
| clofazimine | ||||||
| fbiC | 1304613 | c.1683T>C | synonymous_variant | 1.0 | pretomanid | |
| delamanid | ||||||
| clofazimine | ||||||
| fbiC | 1304634 | c.1704C>G | synonymous_variant | 1.0 | pretomanid | |
| delamanid | ||||||
| clofazimine | ||||||
| fbiC | 1304640 | c.1710A>T | synonymous_variant | 1.0 | pretomanid | |
| delamanid | ||||||
| clofazimine | ||||||
| fbiC | 1304646 | c.1716T>C | synonymous_variant | 1.0 | pretomanid | |
| delamanid | ||||||
| clofazimine | ||||||
| fbiC | 1304658 | c.1728C>G | synonymous_variant | 1.0 | pretomanid | |
| delamanid | ||||||
| clofazimine | ||||||
| fbiC | 1304670 | c.1740G>C | synonymous_variant | 1.0 | pretomanid | |
| delamanid | ||||||
| clofazimine | ||||||
| fbiC | 1304671 | p.Val581Thr | missense_variant | 1.0 | pretomanid | |
| delamanid | ||||||
| clofazimine | ||||||
| fbiC | 1304675 | p.Gly582Asp | missense_variant | 1.0 | pretomanid | |
| delamanid | ||||||
| clofazimine | ||||||
| fbiC | 1304694 | c.1764A>C | synonymous_variant | 1.0 | pretomanid | |
| delamanid | ||||||
| clofazimine | ||||||
| fbiC | 1304706 | c.1776C>T | synonymous_variant | 1.0 | pretomanid | |
| delamanid | ||||||
| clofazimine | ||||||
| fbiC | 1304715 | c.1785G>C | synonymous_variant | 1.0 | pretomanid | |
| delamanid | ||||||
| clofazimine | ||||||
| fbiC | 1304724 | c.1794A>G | synonymous_variant | 1.0 | pretomanid | |
| delamanid | Not assoc w R - Interim | |||||
| clofazimine | Not assoc w R - Interim | |||||
| fbiC | 1304727 | c.1797A>C | synonymous_variant | 1.0 | pretomanid | |
| delamanid | ||||||
| clofazimine | ||||||
| rrs | 1471986 | n.141C>T | non_coding_transcript_exon_variant | 1.0 | kanamycin | Uncertain significance |
| capreomycin | Uncertain significance | |||||
| streptomycin | Uncertain significance | |||||
| amikacin | Uncertain significance | |||||
| rrl | 1473717 | n.60G>T | non_coding_transcript_exon_variant | 1.0 | capreomycin | Uncertain significance |
| linezolid | ||||||
| rrl | 1473746 | n.89T>C | non_coding_transcript_exon_variant | 1.0 | capreomycin | Uncertain significance |
| linezolid | ||||||
| rrl | 1473758 | n.101G>T | non_coding_transcript_exon_variant | 1.0 | capreomycin | Uncertain significance |
| linezolid | ||||||
| rrl | 1473768 | n.111A>G | non_coding_transcript_exon_variant | 1.0 | capreomycin | |
| linezolid | ||||||
| rrl | 1473770 | n.113T>G | non_coding_transcript_exon_variant | 1.0 | capreomycin | Uncertain significance |
| linezolid | Uncertain significance | |||||
| rrl | 1473788 | n.131A>G | non_coding_transcript_exon_variant | 1.0 | capreomycin | Uncertain significance |
| linezolid | ||||||
| rrl | 1473806 | n.149C>T | non_coding_transcript_exon_variant | 1.0 | capreomycin | Uncertain significance |
| linezolid | Uncertain significance | |||||
| rrl | 1473807 | n.150T>C | non_coding_transcript_exon_variant | 1.0 | capreomycin | Uncertain significance |
| linezolid | ||||||
| rrl | 1473813 | n.156C>T | non_coding_transcript_exon_variant | 1.0 | capreomycin | |
| linezolid | ||||||
| rrl | 1473815 | n.158T>C | non_coding_transcript_exon_variant | 1.0 | capreomycin | Uncertain significance |
| linezolid | Uncertain significance | |||||
| rrl | 1473823 | n.166T>C | non_coding_transcript_exon_variant | 1.0 | capreomycin | |
| linezolid | ||||||
| rrl | 1473836 | n.179A>G | non_coding_transcript_exon_variant | 1.0 | capreomycin | |
| linezolid | Uncertain significance | |||||
| rrl | 1473876 | n.219G>A | non_coding_transcript_exon_variant | 1.0 | capreomycin | Uncertain significance |
| linezolid | Uncertain significance | |||||
| rrl | 1473898 | n.241C>T | non_coding_transcript_exon_variant | 1.0 | capreomycin | Uncertain significance |
| linezolid | Uncertain significance | |||||
| rrl | 1473899 | n.242A>G | non_coding_transcript_exon_variant | 1.0 | capreomycin | Uncertain significance |
| linezolid | Uncertain significance | |||||
| inhA | 1674756 | c.555T>C | synonymous_variant | 1.0 | isoniazid | Not assoc w R - Interim |
| ethionamide | Not assoc w R - Interim | |||||
| inhA | 1674759 | c.558G>C | synonymous_variant | 1.0 | isoniazid | |
| ethionamide | ||||||
| inhA | 1674771 | c.570C>G | synonymous_variant | 1.0 | isoniazid | |
| ethionamide | ||||||
| inhA | 1674774 | c.573A>C | synonymous_variant | 1.0 | isoniazid | |
| ethionamide | ||||||
| inhA | 1674777 | c.576C>A | synonymous_variant | 1.0 | isoniazid | |
| ethionamide | ||||||
| inhA | 1674780 | c.579T>G | synonymous_variant | 1.0 | isoniazid | |
| ethionamide | ||||||
| inhA | 1674795 | c.594G>C | synonymous_variant | 1.0 | isoniazid | |
| ethionamide | ||||||
| inhA | 1674801 | c.600T>C | synonymous_variant | 1.0 | isoniazid | |
| ethionamide | ||||||
| inhA | 1674804 | c.603G>C | synonymous_variant | 1.0 | isoniazid | |
| ethionamide | Not assoc w R - Interim | |||||
| inhA | 1674822 | c.621C>G | synonymous_variant | 1.0 | isoniazid | |
| ethionamide | ||||||
| inhA | 1674827 | p.Glu209Ala | missense_variant | 1.0 | isoniazid | |
| ethionamide | ||||||
| inhA | 1674839 | p.Ala213Asp | missense_variant | 1.0 | isoniazid | |
| ethionamide | ||||||
| inhA | 1674846 | p.Ile215Met | missense_variant | 1.0 | isoniazid | |
| ethionamide | ||||||
| inhA | 1674848 | p.Gln216Arg | missense_variant | 1.0 | isoniazid | Uncertain significance |
| ethionamide | ||||||
| inhA | 1674858 | c.657G>A | synonymous_variant | 1.0 | isoniazid | |
| ethionamide | ||||||
| inhA | 1674870 | c.669T>C | synonymous_variant | 1.0 | isoniazid | |
| ethionamide | ||||||
| inhA | 1674879 | c.678T>C | synonymous_variant | 1.0 | isoniazid | |
| ethionamide | ||||||
| inhA | 1674882 | c.681G>C | synonymous_variant | 1.0 | isoniazid | |
| ethionamide | ||||||
| inhA | 1674883 | p.Ile228Val | missense_variant | 1.0 | isoniazid | Uncertain significance |
| ethionamide | Uncertain significance | |||||
| inhA | 1674904 | p.Ala235Pro | missense_variant | 1.0 | isoniazid | |
| ethionamide | ||||||
| Rv2477c | 2783920 | c.123G>C | synonymous_variant | 1.0 | kanamycin | |
| levofloxacin | ||||||
| moxifloxacin | ||||||
| streptomycin | ||||||
| rifampicin | ||||||
| ethambutol | ||||||
| amikacin | ||||||
| Rv2477c | 2783926 | c.117C>G | synonymous_variant | 1.0 | kanamycin | |
| levofloxacin | ||||||
| moxifloxacin | ||||||
| streptomycin | ||||||
| rifampicin | ||||||
| ethambutol | ||||||
| amikacin | ||||||
| Rv2477c | 2783938 | c.105T>C | synonymous_variant | 1.0 | kanamycin | |
| levofloxacin | ||||||
| moxifloxacin | ||||||
| streptomycin | ||||||
| rifampicin | ||||||
| ethambutol | ||||||
| amikacin | ||||||
| Rv2477c | 2783953 | c.90G>C | synonymous_variant | 1.0 | kanamycin | |
| levofloxacin | ||||||
| moxifloxacin | ||||||
| streptomycin | ||||||
| rifampicin | ||||||
| ethambutol | ||||||
| amikacin | ||||||
| Rv2477c | 2783956 | p.Tyr29Leu | missense_variant | 1.0 | kanamycin | |
| levofloxacin | ||||||
| moxifloxacin | ||||||
| streptomycin | ||||||
| rifampicin | ||||||
| ethambutol | ||||||
| amikacin | ||||||
| Rv2477c | 2783962 | p.Ser27Asn | missense_variant | 1.0 | kanamycin | |
| levofloxacin | ||||||
| moxifloxacin | ||||||
| streptomycin | ||||||
| rifampicin | ||||||
| ethambutol | ||||||
| amikacin | ||||||
| Rv2477c | 2783968 | p.Thr25Ser | missense_variant | 1.0 | kanamycin | |
| levofloxacin | ||||||
| moxifloxacin | ||||||
| streptomycin | ||||||
| rifampicin | ||||||
| ethambutol | ||||||
| amikacin | ||||||
| Rv2477c | 2783971 | c.72G>C | synonymous_variant | 1.0 | kanamycin | |
| levofloxacin | ||||||
| moxifloxacin | ||||||
| streptomycin | ||||||
| rifampicin | ||||||
| ethambutol | ||||||
| amikacin | ||||||
| Rv2477c | 2783980 | c.63C>T | synonymous_variant | 1.0 | kanamycin | |
| levofloxacin | ||||||
| moxifloxacin | ||||||
| streptomycin | ||||||
| rifampicin | ||||||
| ethambutol | ||||||
| amikacin | ||||||
| Rv2477c | 2783986 | c.57G>C | synonymous_variant | 1.0 | kanamycin | |
| levofloxacin | ||||||
| moxifloxacin | ||||||
| streptomycin | ||||||
| rifampicin | ||||||
| ethambutol | ||||||
| amikacin | ||||||
| Rv2477c | 2783992 | c.51T>C | synonymous_variant | 1.0 | kanamycin | Not assoc w R - Interim |
| levofloxacin | Not assoc w R - Interim | |||||
| moxifloxacin | ||||||
| streptomycin | Not assoc w R - Interim | |||||
| rifampicin | Not assoc w R - Interim | |||||
| ethambutol | Not assoc w R - Interim | |||||
| amikacin | ||||||
| Rv2477c | 2784016 | p.Lys9Arg | missense_variant | 1.0 | kanamycin | |
| levofloxacin | ||||||
| moxifloxacin | ||||||
| streptomycin | ||||||
| rifampicin | ||||||
| ethambutol | ||||||
| amikacin | ||||||
| lpqB | 3624339 | p.Arg191Pro | missense_variant | 1.0 | rifampicin | |
| bedaquiline | ||||||
| lpqB | 3624365 | c.546T>C | synonymous_variant | 1.0 | rifampicin | |
| bedaquiline | ||||||
| lpqB | 3624371 | c.540T>G | synonymous_variant | 1.0 | rifampicin | |
| bedaquiline | ||||||
| lpqB | 3624374 | c.537G>C | synonymous_variant | 1.0 | rifampicin | |
| bedaquiline | ||||||
| lpqB | 3624380 | p.Lys177Ala | missense_variant | 1.0 | rifampicin | |
| bedaquiline | ||||||
| lpqB | 3624383 | c.528C>G | synonymous_variant | 1.0 | rifampicin | |
| bedaquiline | ||||||
| lpqB | 3624389 | c.522C>G | synonymous_variant | 1.0 | rifampicin | |
| bedaquiline | ||||||
| lpqB | 3624396 | p.Ala172Val | missense_variant | 1.0 | rifampicin | |
| bedaquiline | ||||||
| lpqB | 3624404 | c.507G>C | synonymous_variant | 1.0 | rifampicin | |
| bedaquiline | ||||||
| lpqB | 3624407 | c.504C>G | synonymous_variant | 1.0 | rifampicin | |
| bedaquiline | ||||||
| lpqB | 3624416 | c.495G>A | synonymous_variant | 1.0 | rifampicin | |
| bedaquiline | ||||||
| lpqB | 3624422 | c.489G>C | synonymous_variant | 1.0 | rifampicin | |
| bedaquiline | ||||||
| lpqB | 3624425 | p.Glu162Ser | missense_variant | 1.0 | rifampicin | |
| bedaquiline | ||||||
| lpqB | 3624428 | c.483A>G | synonymous_variant | 1.0 | rifampicin | |
| bedaquiline | ||||||
| lpqB | 3624437 | c.474G>A | synonymous_variant | 1.0 | rifampicin | |
| bedaquiline | ||||||
| lpqB | 3624446 | c.465G>C | synonymous_variant | 1.0 | rifampicin | |
| bedaquiline | ||||||
| lpqB | 3624452 | c.459T>C | synonymous_variant | 1.0 | rifampicin | |
| bedaquiline | ||||||
| lpqB | 3625615 | c.-705G>C | upstream_gene_variant | 0.92 | rifampicin | |
| bedaquiline | ||||||
| mtrB | 3625621 | p.Thr331Ala | missense_variant | 0.92 | rifampicin | |
| bedaquiline | ||||||
| mtrB | 3625636 | p.Ala326Glu | missense_variant | 0.92 | rifampicin | |
| bedaquiline | ||||||
| mtrB | 3625648 | p.Tyr322His | missense_variant | 0.92 | rifampicin | |
| bedaquiline | ||||||
| mtrB | 3625656 | c.958T>C | synonymous_variant | 0.93 | rifampicin | Not assoc w R - Interim |
| bedaquiline | Not assoc w R - Interim | |||||
| mtrB | 3625687 | c.927G>A | synonymous_variant | 0.94 | rifampicin | Not assoc w R - Interim |
| bedaquiline | ||||||
| lpqB | 3625690 | c.-780T>C | upstream_gene_variant | 0.94 | rifampicin | |
| bedaquiline | ||||||
| mtrB | 3625711 | c.903C>T | synonymous_variant | 0.94 | rifampicin | Not assoc w R - Interim |
| bedaquiline | ||||||
| mtrB | 3625720 | c.894G>C | synonymous_variant | 0.95 | rifampicin | Not assoc w R - Interim |
| bedaquiline | ||||||
| mtrB | 3625729 | c.885A>G | synonymous_variant | 0.94 | rifampicin | Not assoc w R - Interim |
| bedaquiline | ||||||
| mtrB | 3625735 | c.879C>A | synonymous_variant | 0.94 | rifampicin | Not assoc w R - Interim |
| bedaquiline | ||||||
| mtrB | 3625747 | c.867G>C | synonymous_variant | 0.94 | rifampicin | Not assoc w R - Interim |
| bedaquiline | ||||||
| mtrA | 3627041 | p.Ile103Val | missense_variant | 1.0 | rifampicin | |
| bedaquiline | ||||||
| mtrB | 3627044 | c.-431C>T | upstream_gene_variant | 1.0 | rifampicin | |
| bedaquiline | ||||||
| mtrB | 3627056 | c.-443C>G | upstream_gene_variant | 1.0 | rifampicin | |
| bedaquiline | ||||||
| mtrB | 3627059 | c.-446G>C | upstream_gene_variant | 1.0 | rifampicin | |
| bedaquiline | ||||||
| rpoA | 3877848 | c.660C>T | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| clpC1 | 4038587 | c.2118C>G | synonymous_variant | 1.0 | pyrazinamide | |
| clpC1 | 4038596 | c.2109A>G | synonymous_variant | 1.0 | pyrazinamide | |
| clpC1 | 4038602 | c.2103G>C | synonymous_variant | 1.0 | pyrazinamide | |
| clpC1 | 4038623 | c.2082A>G | synonymous_variant | 1.0 | pyrazinamide | |
| clpC1 | 4039274 | c.1431G>C | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4039286 | c.1419T>C | synonymous_variant | 1.0 | pyrazinamide | |
| clpC1 | 4039295 | c.1410A>G | synonymous_variant | 1.0 | pyrazinamide | |
| clpC1 | 4039304 | c.1401G>A | synonymous_variant | 1.0 | pyrazinamide | |
| clpC1 | 4039310 | c.1395A>G | synonymous_variant | 1.0 | pyrazinamide | |
| clpC1 | 4039313 | c.1392C>G | synonymous_variant | 1.0 | pyrazinamide | |
| clpC1 | 4039316 | c.1389G>A | synonymous_variant | 1.0 | pyrazinamide | |
| clpC1 | 4039319 | c.1386T>C | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4039322 | c.1383T>C | synonymous_variant | 1.0 | pyrazinamide | |
| clpC1 | 4039328 | c.1377A>G | synonymous_variant | 1.0 | pyrazinamide | |
| clpC1 | 4039334 | c.1371G>C | synonymous_variant | 1.0 | pyrazinamide | |
| clpC1 | 4039338 | p.Thr456Gln | missense_variant | 1.0 | pyrazinamide | |
| clpC1 | 4039347 | p.Arg453Lys | missense_variant | 1.0 | pyrazinamide | |
| glpK | 4138724 | c.1032A>C | synonymous_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| isoniazid | ||||||
| streptomycin | ||||||
| rifampicin | ||||||
| ethambutol | ||||||
| glpK | 4138730 | c.1026C>G | synonymous_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| isoniazid | ||||||
| streptomycin | ||||||
| rifampicin | ||||||
| ethambutol | ||||||
| glpK | 4138748 | c.1008G>A | synonymous_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| isoniazid | ||||||
| streptomycin | ||||||
| rifampicin | ||||||
| ethambutol | ||||||
| glpK | 4138754 | c.1002C>A | synonymous_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| isoniazid | ||||||
| streptomycin | ||||||
| rifampicin | ||||||
| ethambutol | ||||||
| glpK | 4138757 | c.999A>G | synonymous_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| isoniazid | ||||||
| streptomycin | ||||||
| rifampicin | ||||||
| ethambutol | ||||||
| glpK | 4138769 | c.987G>C | synonymous_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| isoniazid | ||||||
| streptomycin | ||||||
| rifampicin | ||||||
| ethambutol | ||||||
| glpK | 4138775 | c.981C>A | synonymous_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| isoniazid | ||||||
| streptomycin | ||||||
| rifampicin | ||||||
| ethambutol | ||||||
| embB | 4247491 | c.978G>C | synonymous_variant | 1.0 | ethambutol | |
| embB | 4247500 | c.987C>G | synonymous_variant | 1.0 | ethambutol | |
| embB | 4247512 | c.999T>C | synonymous_variant | 1.0 | ethambutol | |
| embB | 4247539 | c.1026T>C | synonymous_variant | 1.0 | ethambutol | |
| embB | 4247554 | c.1041T>C | synonymous_variant | 1.0 | ethambutol | |
| embB | 4247555 | p.Leu348Ile | missense_variant | 1.0 | ethambutol | |
| embB | 4247566 | c.1053C>G | synonymous_variant | 1.0 | ethambutol | |
| embB | 4247572 | c.1059A>C | synonymous_variant | 1.0 | ethambutol | |
| embB | 4247579 | p.Ala356Ile | missense_variant | 1.0 | ethambutol | |
| embB | 4247582 | p.Ala357Cys | missense_variant | 1.0 | ethambutol | |
| embB | 4247587 | c.1074G>A | synonymous_variant | 1.0 | ethambutol | |
| embB | 4247603 | c.1090C>T | synonymous_variant | 1.0 | ethambutol | |
| embB | 4247611 | c.1098G>C | synonymous_variant | 1.0 | ethambutol | |
| embB | 4248097 | c.1584C>G | synonymous_variant | 1.0 | ethambutol | |
| embB | 4248106 | c.1593C>G | synonymous_variant | 1.0 | ethambutol | |
| embB | 4248109 | c.1596C>G | synonymous_variant | 1.0 | ethambutol | |
| embB | 4248112 | c.1599C>G | synonymous_variant | 1.0 | ethambutol | |
| embB | 4248118 | c.1605T>C | synonymous_variant | 1.0 | ethambutol | |
| embB | 4248130 | c.1617G>C | synonymous_variant | 1.0 | ethambutol | |
| embB | 4248142 | c.1629T>C | synonymous_variant | 1.0 | ethambutol | |
| embB | 4248143 | p.Leu544Ile | missense_variant | 1.0 | ethambutol | |
| embB | 4248154 | c.1641G>A | synonymous_variant | 1.0 | ethambutol | Not assoc w R - Interim |
| embB | 4248157 | c.1644A>G | synonymous_variant | 1.0 | ethambutol | Not assoc w R - Interim |
| embB | 4248159 | p.Cys549Ser | missense_variant | 1.0 | ethambutol | |
| embB | 4248167 | p.Thr552Ala | missense_variant | 1.0 | ethambutol | |
| embB | 4248172 | c.1659G>C | synonymous_variant | 0.88 | ethambutol | |
| embB | 4248173 | p.Val554Met | missense_variant | 1.0 | ethambutol | |
| embB | 4248199 | c.1686A>G | synonymous_variant | 1.0 | ethambutol | |
| embB | 4248200 | p.Ile563Val | missense_variant | 1.0 | ethambutol | |
| embB | 4248206 | p.Ser565Gly | missense_variant | 1.0 | ethambutol | Uncertain significance |
| embB | 4248211 | c.1698G>C | synonymous_variant | 1.0 | ethambutol | |
| embB | 4248220 | c.1707A>G | synonymous_variant | 1.0 | ethambutol | Not assoc w R - Interim |
| embB | 4248226 | c.1713G>C | synonymous_variant | 1.0 | ethambutol |
