Run ID: ERR11488822
Sample name:
Date: 2024-04-15T08:38:44.113350
Number of reads: 2902949
Percentage reads mapped: 96.46
Median coverage: 78.0
Strain: lineage2.2.1;lineage4.1.2.1
Spoligotype:
Drug-resistance: Pre-XDR-TB
Lineage | Family | RDs | Frequency |
---|---|---|---|
lineage2 | East-Asian | RD105 | 0.88 |
lineage4.1 | Euro-American | None | 0.09 |
lineage4.1.2 | Euro-American | None | 0.05 |
lineage4.1.2.1 | Euro-American (Haarlem) | RD182 | 0.06 |
lineage2.2.1 | East-Asian (Beijing) | RD105;RD207;RD181 | 0.89 |
lineage2.2 | East-Asian (Beijing) | RD105;RD207 | 0.89 |
lineage4 | Euro-American | None | 0.11 |
Drug | Resistance | Supporting mutations | WHO confidence | Comment |
---|---|---|---|---|
rifampicin | rpoB | p.Ser450Leu | Assoc w R | |
isoniazid | inhA | c.-777C>T | Assoc w R | Alias fabG1_c.-15C>T. Low-level resistance (multiple, genetically linked low-level resistance mutations are additive and confer high-level resistance) |
katG | p.Ser315Thr | Assoc w R | High-level resistance | |
ethambutol | embB | p.Met306Val | Assoc w R | |
pyrazinamide | pncA | p.Thr135Pro | Assoc w R | |
streptomycin | ||||
fluoroquinolones | ||||
moxifloxacin | gyrA | p.Asp89Asn | Assoc w R | Low-level resistance (multiple, genetically linked low-level resistance mutations are additive and confer high-level resistance) |
ofloxacin | ||||
levofloxacin | gyrA | p.Asp89Asn | Assoc w R | |
ciprofloxacin | ||||
aminoglycosides | ||||
amikacin | ||||
capreomycin | ||||
kanamycin | ||||
cycloserine | ||||
ethionamide | inhA | c.-777C>T | Assoc w R | Alias fabG1_c.-15C>T |
ethR | p.Ala95Thr | Uncertain significance | Mutation from literature | |
clofazimine | ||||
para-aminosalicylic_acid | ||||
delamanid | ||||
bedaquiline | ||||
linezolid |
Gene | Chromosome position | Mutation | Type | Estimated fraction | Drugs | Confidence | Comment |
---|---|---|---|---|---|---|---|
gyrA | 7566 | p.Asp89Asn | missense_variant | 0.79 | levofloxacin | Assoc w R | |
moxifloxacin | Assoc w R | Low-level resistance (multiple, genetically linked low-level resistance mutations are additive and confer high-level resistance) | |||||
rpoB | 761155 | p.Ser450Leu | missense_variant | 0.94 | rifampicin | Assoc w R | |
inhA | 1673425 | c.-777C>T | upstream_gene_variant | 0.9 | ethionamide | Assoc w R | Alias fabG1_c.-15C>T |
isoniazid | Assoc w R | Alias fabG1_c.-15C>T. Low-level resistance (multiple, genetically linked low-level resistance mutations are additive and confer high-level resistance) | |||||
katG | 2155168 | p.Ser315Thr | missense_variant | 0.14 | isoniazid | Assoc w R | High-level resistance |
pncA | 2288839 | p.Thr135Pro | missense_variant | 0.15 | pyrazinamide | Assoc w R | |
embB | 4247429 | p.Met306Val | missense_variant | 0.86 | ethambutol | Assoc w R | |
ethR | 4327831 | p.Ala95Thr | missense_variant | 0.9 | ethionamide | Uncertain significance | Mutation from literature |
Gene | Chromosome position | Mutation | Type | Estimated fraction | Drugs | Confidence |
---|---|---|---|---|---|---|
gyrA | 7362 | p.Glu21Gln | missense_variant | 1.0 | levofloxacin | Not assoc w R |
moxifloxacin | Not assoc w R | |||||
gyrA | 7585 | p.Ser95Thr | missense_variant | 1.0 | levofloxacin | Not assoc w R |
moxifloxacin | Not assoc w R | |||||
gyrA | 8693 | c.1392T>C | synonymous_variant | 0.2 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8711 | c.1410A>C | synonymous_variant | 0.19 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8714 | c.1413A>G | synonymous_variant | 0.19 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8729 | c.1428T>C | synonymous_variant | 0.16 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8731 | p.Gly477Ala | missense_variant | 0.16 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8751 | p.Ala484Asn | missense_variant | 0.14 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8762 | c.1461G>C | synonymous_variant | 0.15 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 8767 | p.Arg489Lys | missense_variant | 0.14 | levofloxacin | Uncertain significance |
moxifloxacin | Uncertain significance | |||||
gyrA | 8783 | c.1482G>C | synonymous_variant | 0.13 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 9304 | p.Gly668Asp | missense_variant | 1.0 | levofloxacin | Not assoc w R |
moxifloxacin | Not assoc w R | |||||
gyrA | 9583 | p.Arg761Lys | missense_variant | 0.14 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 9585 | c.2284T>C | synonymous_variant | 0.14 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 9590 | c.2289T>C | synonymous_variant | 0.14 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 9599 | p.Leu766Phe | missense_variant | 0.13 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 9623 | c.2322G>C | synonymous_variant | 0.17 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 9626 | c.2325T>C | synonymous_variant | 0.16 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 9630 | p.Val777Ile | missense_variant | 0.17 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 9635 | c.2334T>C | synonymous_variant | 0.17 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 9644 | c.2343T>C | synonymous_variant | 0.17 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 9650 | c.2349G>C | synonymous_variant | 0.18 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 9665 | c.2364A>G | synonymous_variant | 0.19 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 9674 | c.2373T>C | synonymous_variant | 0.21 | levofloxacin | |
moxifloxacin | ||||||
fgd1 | 491742 | c.960T>C | synonymous_variant | 0.96 | clofazimine | Not assoc w R |
pretomanid | ||||||
delamanid | Not assoc w R - Interim | |||||
mshA | 575772 | p.Val142Ala | missense_variant | 0.13 | ethionamide | |
isoniazid | ||||||
mshA | 575782 | c.435G>C | synonymous_variant | 0.17 | ethionamide | |
isoniazid | ||||||
mshA | 575785 | c.438T>G | synonymous_variant | 0.2 | ethionamide | |
isoniazid | ||||||
mshA | 575806 | c.459G>C | synonymous_variant | 0.26 | ethionamide | |
isoniazid | ||||||
mshA | 575824 | c.477T>C | synonymous_variant | 0.28 | ethionamide | |
isoniazid | ||||||
mshA | 575842 | c.495G>C | synonymous_variant | 0.26 | ethionamide | |
isoniazid | ||||||
mshA | 575848 | c.501C>T | synonymous_variant | 0.26 | ethionamide | |
isoniazid | ||||||
mshA | 575878 | c.531A>C | synonymous_variant | 0.22 | ethionamide | |
isoniazid | ||||||
mshA | 575881 | c.534C>T | synonymous_variant | 0.22 | ethionamide | |
isoniazid | ||||||
mshA | 575887 | c.540G>C | synonymous_variant | 0.27 | ethionamide | |
isoniazid | ||||||
mshA | 575893 | c.546C>G | synonymous_variant | 0.26 | ethionamide | |
isoniazid | ||||||
mshA | 575907 | p.Ala187Val | missense_variant | 0.73 | ethionamide | Not assoc w R |
isoniazid | Not assoc w R | |||||
ccsA | 620247 | p.Leu119Phe | missense_variant | 0.18 | capreomycin | |
amikacin | ||||||
kanamycin | ||||||
ccsA | 620249 | p.Ser120Cys | missense_variant | 0.18 | capreomycin | |
amikacin | ||||||
kanamycin | ||||||
ccsA | 620253 | c.363G>C | synonymous_variant | 0.17 | capreomycin | |
amikacin | ||||||
kanamycin | ||||||
ccsA | 620256 | c.366C>G | synonymous_variant | 0.18 | capreomycin | |
amikacin | ||||||
kanamycin | ||||||
ccsA | 620257 | p.Ile123Val | missense_variant | 0.17 | capreomycin | |
amikacin | ||||||
kanamycin | ||||||
ccsA | 620268 | c.378G>C | synonymous_variant | 0.17 | capreomycin | |
amikacin | ||||||
kanamycin | ||||||
ccsA | 620283 | c.393T>G | synonymous_variant | 0.14 | capreomycin | |
amikacin | Not assoc w R - Interim | |||||
kanamycin | Not assoc w R - Interim | |||||
ccsA | 620284 | p.Ala132Pro | missense_variant | 0.14 | capreomycin | |
amikacin | ||||||
kanamycin | ||||||
ccsA | 620288 | p.Arg133Gln | missense_variant | 0.14 | capreomycin | |
amikacin | ||||||
kanamycin | ||||||
ccsA | 620291 | p.Tyr134Phe | missense_variant | 0.14 | capreomycin | |
amikacin | ||||||
kanamycin | ||||||
ccsA | 620295 | c.405G>C | synonymous_variant | 0.16 | capreomycin | |
amikacin | ||||||
kanamycin | ||||||
ccsA | 620307 | c.417C>G | synonymous_variant | 0.17 | capreomycin | |
amikacin | ||||||
kanamycin | ||||||
ccsA | 620310 | c.420C>T | synonymous_variant | 0.17 | capreomycin | |
amikacin | ||||||
kanamycin | ||||||
ccsA | 620317 | c.427_429delGTCinsCG | frameshift_variant&missense_variant | 0.17 | capreomycin | |
amikacin | ||||||
kanamycin | ||||||
ccsA | 620337 | c.447C>G | synonymous_variant | 0.16 | capreomycin | |
amikacin | ||||||
kanamycin | ||||||
ccsA | 620343 | c.453G>C | synonymous_variant | 0.16 | capreomycin | |
amikacin | ||||||
kanamycin | ||||||
ccsA | 620349 | c.459A>T | synonymous_variant | 0.13 | capreomycin | |
amikacin | ||||||
kanamycin | ||||||
ccsA | 620625 | p.Ile245Met | missense_variant | 0.85 | capreomycin | Not assoc w R |
amikacin | Not assoc w R | |||||
kanamycin | Uncertain significance | |||||
Rv0565c | 657081 | c.390G>A | synonymous_variant | 0.88 | ethionamide | Not assoc w R - Interim |
Rv0565c | 657142 | p.Arg110His | missense_variant | 0.89 | ethionamide | Uncertain significance |
Rv0565c | 657671 | c.-201A>G | upstream_gene_variant | 0.15 | ethionamide | |
Rv0565c | 657686 | c.-216C>A | upstream_gene_variant | 0.19 | ethionamide | |
Rv0565c | 657689 | c.-220_-219delCAinsAG | upstream_gene_variant | 0.21 | ethionamide | |
Rv0565c | 657734 | c.-264T>C | upstream_gene_variant | 0.27 | ethionamide | |
nusG | 734147 | c.-107T>C | upstream_gene_variant | 0.15 | rifampicin | |
nusG | 734150 | c.-104G>C | upstream_gene_variant | 0.15 | rifampicin | |
nusG | 734180 | c.-74T>G | upstream_gene_variant | 0.16 | rifampicin | Uncertain significance |
nusG | 734186 | c.-68G>C | upstream_gene_variant | 0.18 | rifampicin | Uncertain significance |
nusG | 734193 | c.-61A>G | upstream_gene_variant | 0.17 | rifampicin | |
nusG | 734201 | c.-53G>C | upstream_gene_variant | 0.18 | rifampicin | |
nusG | 734205 | c.-49A>C | upstream_gene_variant | 0.19 | rifampicin | |
nusG | 734208 | c.-46T>C | upstream_gene_variant | 0.19 | rifampicin | |
nusG | 734224 | c.-30_-29delGCinsCTT | upstream_gene_variant | 0.19 | rifampicin | |
nusG | 734234 | c.-20G>T | upstream_gene_variant | 0.18 | rifampicin | |
nusG | 734239 | c.-15A>G | upstream_gene_variant | 0.18 | rifampicin | Uncertain significance |
nusG | 734240 | c.-14G>A | upstream_gene_variant | 0.19 | rifampicin | |
nusG | 734249 | c.-5A>C | upstream_gene_variant | 0.18 | rifampicin | |
nusG | 734514 | c.261A>G | synonymous_variant | 0.17 | rifampicin | |
nusG | 734532 | c.279A>G | synonymous_variant | 0.14 | rifampicin | Not assoc w R - Interim |
nusG | 734541 | c.288A>G | synonymous_variant | 0.17 | rifampicin | Not assoc w R - Interim |
nusG | 734559 | c.306T>C | synonymous_variant | 0.18 | rifampicin | |
nusG | 734580 | c.327T>C | synonymous_variant | 0.18 | rifampicin | Not assoc w R - Interim |
nusG | 734589 | c.336G>C | synonymous_variant | 0.17 | rifampicin | |
nusG | 734610 | c.357C>G | synonymous_variant | 0.14 | rifampicin | |
nusG | 734625 | c.372T>C | synonymous_variant | 0.14 | rifampicin | |
rpoB | 760115 | c.309C>T | synonymous_variant | 0.19 | rifampicin | Not assoc w R |
rpoB | 760337 | c.531C>G | synonymous_variant | 0.15 | rifampicin | |
rpoB | 760340 | c.534G>T | synonymous_variant | 0.13 | rifampicin | Not assoc w R - Interim |
rpoB | 760361 | c.555T>C | synonymous_variant | 0.18 | rifampicin | Not assoc w R - Interim |
rpoB | 760373 | c.567C>T | synonymous_variant | 0.21 | rifampicin | |
rpoB | 760376 | p.Asp190Glu | missense_variant | 0.23 | rifampicin | Uncertain significance |
rpoB | 760403 | c.597C>T | synonymous_variant | 0.23 | rifampicin | Not assoc w R - Interim |
rpoB | 760406 | c.600G>C | synonymous_variant | 0.23 | rifampicin | |
rpoB | 760418 | c.612G>C | synonymous_variant | 0.22 | rifampicin | Not assoc w R - Interim |
rpoB | 760430 | c.624T>C | synonymous_variant | 0.21 | rifampicin | Not assoc w R - Interim |
rpoB | 760475 | c.669A>G | synonymous_variant | 0.18 | rifampicin | Not assoc w R - Interim |
rpoB | 760484 | c.678A>G | synonymous_variant | 0.15 | rifampicin | Not assoc w R - Interim |
rpoB | 760919 | c.1113C>G | synonymous_variant | 0.14 | rifampicin | |
rpoB | 760920 | c.1114C>T | synonymous_variant | 0.14 | rifampicin | |
rpoB | 760925 | c.1119T>C | synonymous_variant | 0.14 | rifampicin | |
rpoB | 760931 | c.1125C>G | synonymous_variant | 0.16 | rifampicin | |
rpoB | 760946 | c.1140A>G | synonymous_variant | 0.17 | rifampicin | Not assoc w R - Interim |
rpoB | 760970 | c.1164G>C | synonymous_variant | 0.17 | rifampicin | Not assoc w R - Interim |
rpoB | 760971 | c.1165C>A | synonymous_variant | 0.17 | rifampicin | |
rpoB | 760982 | c.1176G>C | synonymous_variant | 0.18 | rifampicin | Not assoc w R - Interim |
rpoB | 760985 | c.1179G>C | synonymous_variant | 0.2 | rifampicin | Not assoc w R - Interim |
rpoB | 761015 | c.1209G>C | synonymous_variant | 0.19 | rifampicin | Not assoc w R - Interim |
rpoB | 761021 | c.1215G>C | synonymous_variant | 0.18 | rifampicin | |
rpoB | 761027 | c.1221A>G | synonymous_variant | 0.16 | rifampicin | Not assoc w R - Interim |
rpoB | 761234 | c.1428G>C | synonymous_variant | 0.14 | rifampicin | Not assoc w R - Interim |
rpoB | 761249 | c.1443A>G | synonymous_variant | 0.14 | rifampicin | Not assoc w R - Interim |
rpoB | 761252 | c.1446C>G | synonymous_variant | 0.13 | rifampicin | |
rpoB | 761261 | c.1455G>T | synonymous_variant | 0.16 | rifampicin | Not assoc w R - Interim |
rpoB | 761264 | c.1458C>G | synonymous_variant | 0.18 | rifampicin | Not assoc w R - Interim |
rpoB | 761314 | p.Phe503Ser | missense_variant | 0.62 | rifampicin | Uncertain significance |
rpoB | 761327 | c.1521A>G | synonymous_variant | 0.18 | rifampicin | Not assoc w R - Interim |
rpoB | 761330 | c.1524G>C | synonymous_variant | 0.18 | rifampicin | |
rpoB | 761333 | c.1527G>T | synonymous_variant | 0.17 | rifampicin | Not assoc w R - Interim |
rpoB | 761354 | c.1548C>T | synonymous_variant | 0.14 | rifampicin | |
rpoB | 761657 | c.1851C>G | synonymous_variant | 0.14 | rifampicin | Not assoc w R - Interim |
rpoB | 761675 | c.1869G>C | synonymous_variant | 0.17 | rifampicin | |
rpoC | 762467 | c.-903C>T | upstream_gene_variant | 0.16 | rifampicin | |
rpoC | 762476 | c.-894C>G | upstream_gene_variant | 0.18 | rifampicin | |
rpoB | 762488 | c.2682G>C | synonymous_variant | 0.19 | rifampicin | Not assoc w R - Interim |
rpoB | 762491 | c.2685T>C | synonymous_variant | 0.17 | rifampicin | Not assoc w R - Interim |
rpoB | 762510 | c.2704_2706delGCCinsCG | frameshift_variant&missense_variant | 0.2 | rifampicin | |
rpoC | 762533 | c.-837T>C | upstream_gene_variant | 0.24 | rifampicin | |
rpoC | 762536 | c.-834T>C | upstream_gene_variant | 0.23 | rifampicin | |
rpoC | 762537 | c.-833T>C | upstream_gene_variant | 0.23 | rifampicin | |
rpoC | 762545 | c.-825C>G | upstream_gene_variant | 0.26 | rifampicin | |
rpoC | 762551 | c.-819C>T | upstream_gene_variant | 0.26 | rifampicin | |
rpoC | 762581 | c.-789T>C | upstream_gene_variant | 0.22 | rifampicin | |
rpoC | 762582 | c.-788T>C | upstream_gene_variant | 0.22 | rifampicin | |
rpoC | 762590 | c.-780C>G | upstream_gene_variant | 0.2 | rifampicin | |
rpoC | 762596 | c.-774G>C | upstream_gene_variant | 0.19 | rifampicin | |
rpoB | 762599 | c.2793T>C | synonymous_variant | 0.2 | rifampicin | Not assoc w R - Interim |
rpoC | 762605 | c.-765T>C | upstream_gene_variant | 0.19 | rifampicin | |
rpoC | 762608 | c.-762C>G | upstream_gene_variant | 0.16 | rifampicin | |
rpoB | 762929 | c.3123G>C | synonymous_variant | 0.16 | rifampicin | Not assoc w R - Interim |
rpoB | 762995 | c.3189G>T | synonymous_variant | 0.16 | rifampicin | Not assoc w R - Interim |
rpoB | 763031 | c.3225T>C | synonymous_variant | 0.67 | rifampicin | Not assoc w R |
rpoB | 763070 | c.3264T>C | synonymous_variant | 0.18 | rifampicin | Not assoc w R - Interim |
rpoB | 763085 | c.3279C>G | synonymous_variant | 0.19 | rifampicin | Not assoc w R - Interim |
rpoC | 763103 | c.-267G>C | upstream_gene_variant | 0.21 | rifampicin | |
rpoB | 763115 | c.3309T>C | synonymous_variant | 0.18 | rifampicin | Not assoc w R - Interim |
rpoB | 763127 | c.3321G>C | synonymous_variant | 0.15 | rifampicin | Not assoc w R - Interim |
rpoB | 763166 | c.3360A>G | synonymous_variant | 0.17 | rifampicin | Not assoc w R - Interim |
rpoC | 763169 | c.-201A>G | upstream_gene_variant | 0.16 | rifampicin | |
rpoC | 763202 | c.-168A>G | upstream_gene_variant | 0.15 | rifampicin | |
rpoC | 763408 | c.39T>C | synonymous_variant | 0.2 | rifampicin | Not assoc w R - Interim |
rpoC | 763411 | c.42T>G | synonymous_variant | 0.19 | rifampicin | Not assoc w R - Interim |
rpoC | 763414 | c.45T>C | synonymous_variant | 0.18 | rifampicin | |
rpoC | 763441 | c.72C>T | synonymous_variant | 0.19 | rifampicin | |
rpoC | 763444 | c.75T>C | synonymous_variant | 0.19 | rifampicin | Not assoc w R - Interim |
rpoC | 763456 | c.87A>G | synonymous_variant | 0.21 | rifampicin | Not assoc w R - Interim |
rpoC | 763486 | c.117T>G | synonymous_variant | 0.22 | rifampicin | |
rpoC | 763528 | c.159G>A | synonymous_variant | 0.16 | rifampicin | Not assoc w R - Interim |
rpoC | 763537 | c.168C>G | synonymous_variant | 0.16 | rifampicin | |
rpoC | 763546 | c.177A>G | synonymous_variant | 0.15 | rifampicin | Not assoc w R - Interim |
rpoC | 763555 | c.186C>T | synonymous_variant | 0.72 | rifampicin | Not assoc w R - Interim |
rpoC | 763570 | c.201G>C | synonymous_variant | 0.14 | rifampicin | Not assoc w R - Interim |
rpoC | 763660 | c.291T>G | synonymous_variant | 0.13 | rifampicin | Not assoc w R - Interim |
rpoC | 763813 | c.444C>G | synonymous_variant | 0.14 | rifampicin | |
rpoC | 763831 | c.462A>G | synonymous_variant | 0.15 | rifampicin | |
rpoC | 763835 | p.Ala156Met | missense_variant | 0.14 | rifampicin | |
rpoC | 763851 | p.Ala161Gly | missense_variant | 0.14 | rifampicin | |
rpoC | 763894 | c.525A>G | synonymous_variant | 0.17 | rifampicin | |
rpoC | 763921 | c.552G>C | synonymous_variant | 0.22 | rifampicin | |
rpoC | 763933 | c.564C>T | synonymous_variant | 0.26 | rifampicin | Not assoc w R - Interim |
rpoC | 763945 | c.576T>C | synonymous_variant | 0.24 | rifampicin | |
rpoC | 763948 | c.579G>C | synonymous_variant | 0.24 | rifampicin | |
rpoC | 763960 | c.591T>C | synonymous_variant | 0.23 | rifampicin | Not assoc w R - Interim |
rpoC | 763963 | c.594C>G | synonymous_variant | 0.24 | rifampicin | |
rpoC | 764005 | c.636G>C | synonymous_variant | 0.23 | rifampicin | Not assoc w R - Interim |
rpoC | 764011 | c.642T>C | synonymous_variant | 0.23 | rifampicin | |
rpoC | 764024 | c.655T>C | synonymous_variant | 0.24 | rifampicin | |
rpoC | 764040 | p.Ser224Asn | missense_variant | 0.22 | rifampicin | |
rpoC | 764044 | c.675T>C | synonymous_variant | 0.22 | rifampicin | |
rpoC | 764059 | c.690G>C | synonymous_variant | 0.19 | rifampicin | |
rpoC | 764083 | c.714A>G | synonymous_variant | 0.19 | rifampicin | |
rpoC | 764087 | p.Leu240Ile | missense_variant | 0.21 | rifampicin | |
rpoC | 764098 | c.729A>G | synonymous_variant | 0.19 | rifampicin | Not assoc w R - Interim |
rpoC | 764101 | c.732C>G | synonymous_variant | 0.19 | rifampicin | Not assoc w R - Interim |
rpoC | 764131 | c.762T>C | synonymous_variant | 0.16 | rifampicin | |
rpoC | 764140 | c.771C>T | synonymous_variant | 0.22 | rifampicin | Not assoc w R - Interim |
rpoC | 764188 | c.819A>G | synonymous_variant | 0.17 | rifampicin | Not assoc w R - Interim |
rpoC | 764194 | c.825G>A | synonymous_variant | 0.16 | rifampicin | |
rpoC | 764203 | c.834G>T | synonymous_variant | 0.15 | rifampicin | |
rpoC | 764206 | p.Asp279Glu | missense_variant | 0.14 | rifampicin | |
rpoC | 764217 | p.Asn283Ser | missense_variant | 0.14 | rifampicin | |
rpoC | 764650 | c.1281G>T | synonymous_variant | 0.13 | rifampicin | Not assoc w R - Interim |
rpoC | 765383 | p.Met672Leu | missense_variant | 0.15 | rifampicin | Uncertain significance |
rpoC | 765403 | c.2034G>C | synonymous_variant | 0.17 | rifampicin | |
rpoC | 765404 | p.Leu679Val | missense_variant | 0.17 | rifampicin | |
rpoC | 765409 | c.2040T>G | synonymous_variant | 0.17 | rifampicin | Not assoc w R - Interim |
rpoC | 765421 | c.2052C>G | synonymous_variant | 0.21 | rifampicin | Not assoc w R - Interim |
rpoC | 765454 | c.2085C>G | synonymous_variant | 0.22 | rifampicin | Not assoc w R - Interim |
rpoC | 765478 | c.2109T>C | synonymous_variant | 0.18 | rifampicin | Not assoc w R - Interim |
rpoC | 765499 | c.2130C>G | synonymous_variant | 0.16 | rifampicin | Not assoc w R - Interim |
rpoC | 765688 | c.2319G>A | synonymous_variant | 0.16 | rifampicin | |
rpoC | 765694 | c.2325G>C | synonymous_variant | 0.16 | rifampicin | |
rpoC | 765700 | c.2331T>C | synonymous_variant | 0.16 | rifampicin | Not assoc w R - Interim |
rpoC | 765712 | c.2343C>G | synonymous_variant | 0.19 | rifampicin | |
rpoC | 765724 | c.2355C>G | synonymous_variant | 0.22 | rifampicin | Not assoc w R - Interim |
rpoC | 765734 | c.2365T>C | synonymous_variant | 0.22 | rifampicin | Not assoc w R - Interim |
rpoC | 765752 | p.Asp795Ser | missense_variant | 0.23 | rifampicin | |
rpoC | 765763 | c.2394G>C | synonymous_variant | 0.28 | rifampicin | |
rpoC | 765772 | c.2403C>G | synonymous_variant | 0.23 | rifampicin | |
rpoC | 765784 | c.2415C>G | synonymous_variant | 0.2 | rifampicin | |
rpoC | 765787 | c.2418C>T | synonymous_variant | 0.23 | rifampicin | |
rpoC | 765793 | c.2424C>G | synonymous_variant | 0.26 | rifampicin | |
rpoC | 765796 | c.2427C>T | synonymous_variant | 0.25 | rifampicin | |
rpoC | 765811 | c.2442T>C | synonymous_variant | 0.29 | rifampicin | Not assoc w R - Interim |
rpoC | 765814 | c.2445A>G | synonymous_variant | 0.29 | rifampicin | Not assoc w R - Interim |
rpoC | 765826 | c.2457T>C | synonymous_variant | 0.28 | rifampicin | Not assoc w R - Interim |
rpoC | 765835 | c.2466C>T | synonymous_variant | 0.28 | rifampicin | Not assoc w R - Interim |
rpoC | 765883 | c.2514C>G | synonymous_variant | 0.32 | rifampicin | |
rpoC | 765886 | c.2517C>G | synonymous_variant | 0.33 | rifampicin | |
rpoC | 765892 | c.2523T>C | synonymous_variant | 0.36 | rifampicin | Not assoc w R - Interim |
rpoC | 765967 | c.2598C>T | synonymous_variant | 0.24 | rifampicin | Not assoc w R - Interim |
rpoC | 765982 | c.2613C>G | synonymous_variant | 0.26 | rifampicin | |
rpoC | 765994 | c.2625A>T | synonymous_variant | 0.2 | rifampicin | Not assoc w R - Interim |
rpoC | 766012 | c.2643C>G | synonymous_variant | 0.15 | rifampicin | Not assoc w R - Interim |
rpoC | 766021 | c.2652G>C | synonymous_variant | 0.16 | rifampicin | |
rpoC | 766027 | c.2658G>C | synonymous_variant | 0.15 | rifampicin | |
rpoC | 766030 | c.2661C>G | synonymous_variant | 0.14 | rifampicin | |
rpoC | 766312 | c.2943T>G | synonymous_variant | 0.18 | rifampicin | |
rpoC | 766315 | c.2946C>G | synonymous_variant | 0.17 | rifampicin | |
rpoC | 766333 | c.2964G>C | synonymous_variant | 0.19 | rifampicin | |
rpoC | 766345 | c.2976T>C | synonymous_variant | 0.21 | rifampicin | |
rpoC | 766348 | c.2979A>G | synonymous_variant | 0.2 | rifampicin | Not assoc w R - Interim |
rpoC | 766366 | c.2997C>G | synonymous_variant | 0.23 | rifampicin | |
rpoC | 766369 | c.3000C>G | synonymous_variant | 0.23 | rifampicin | |
rpoC | 766381 | c.3012C>T | synonymous_variant | 0.25 | rifampicin | |
rpoC | 766384 | c.3015A>G | synonymous_variant | 0.27 | rifampicin | |
rpoC | 766387 | c.3018C>G | synonymous_variant | 0.28 | rifampicin | Not assoc w R - Interim |
rpoC | 766393 | c.3024C>G | synonymous_variant | 0.26 | rifampicin | |
rpoC | 766402 | c.3033C>G | synonymous_variant | 0.26 | rifampicin | |
rpoC | 766408 | c.3039C>G | synonymous_variant | 0.24 | rifampicin | |
rpoC | 766426 | c.3057C>T | synonymous_variant | 0.21 | rifampicin | |
rpoC | 766447 | c.3078T>C | synonymous_variant | 0.19 | rifampicin | |
rpoC | 766459 | c.3090G>C | synonymous_variant | 0.16 | rifampicin | |
rpoC | 766483 | c.3114G>C | synonymous_variant | 0.15 | rifampicin | |
rpoC | 766486 | c.3117A>G | synonymous_variant | 0.15 | rifampicin | |
rpoC | 766488 | p.Pro1040Arg | missense_variant | 0.16 | rifampicin | Uncertain significance |
rpoC | 766492 | c.3123T>C | synonymous_variant | 0.15 | rifampicin | |
rpoC | 766726 | c.3357T>C | synonymous_variant | 0.19 | rifampicin | |
rpoC | 766733 | c.3364C>T | synonymous_variant | 0.19 | rifampicin | |
rpoC | 766738 | c.3369G>C | synonymous_variant | 0.19 | rifampicin | |
rpoC | 766765 | c.3396A>C | synonymous_variant | 0.23 | rifampicin | Not assoc w R - Interim |
rpoC | 766774 | c.3405T>C | synonymous_variant | 0.24 | rifampicin | |
rpoC | 766801 | c.3432C>G | synonymous_variant | 0.21 | rifampicin | |
rpoC | 766804 | c.3435A>G | synonymous_variant | 0.22 | rifampicin | Not assoc w R - Interim |
rpoC | 766861 | c.3492G>C | synonymous_variant | 0.16 | rifampicin | Not assoc w R - Interim |
rpoC | 766864 | c.3495G>C | synonymous_variant | 0.17 | rifampicin | |
rpoC | 766882 | c.3513C>T | synonymous_variant | 0.17 | rifampicin | Not assoc w R - Interim |
rpoC | 766883 | p.Ser1172Ala | missense_variant | 0.17 | rifampicin | Uncertain significance |
rpoC | 766945 | c.3576A>G | synonymous_variant | 0.17 | rifampicin | Not assoc w R - Interim |
rpoC | 766963 | c.3594T>C | synonymous_variant | 0.19 | rifampicin | Not assoc w R - Interim |
rpoC | 766972 | c.3603G>C | synonymous_variant | 0.27 | rifampicin | |
rpoC | 766996 | c.3627C>T | synonymous_variant | 0.29 | rifampicin | Not assoc w R - Interim |
rpoC | 767023 | c.3654C>T | synonymous_variant | 0.25 | rifampicin | Not assoc w R - Interim |
rpoC | 767033 | c.3664_3666delTCGinsAGC | synonymous_variant | 0.28 | rifampicin | |
rpoC | 767059 | c.3690T>G | synonymous_variant | 0.3 | rifampicin | Not assoc w R - Interim |
rpoC | 767062 | c.3693C>A | synonymous_variant | 0.29 | rifampicin | |
rpoC | 767098 | c.3729T>C | synonymous_variant | 0.29 | rifampicin | Not assoc w R - Interim |
rpoC | 767119 | c.3750A>G | synonymous_variant | 0.2 | rifampicin | Not assoc w R - Interim |
rpoC | 767134 | c.3765C>A | synonymous_variant | 0.19 | rifampicin | |
rpoC | 767152 | c.3783T>C | synonymous_variant | 0.19 | rifampicin | Not assoc w R - Interim |
rpoC | 767158 | c.3789T>C | synonymous_variant | 0.19 | rifampicin | Not assoc w R - Interim |
rpoC | 767167 | c.3798C>G | synonymous_variant | 0.19 | rifampicin | Not assoc w R - Interim |
mmpL5 | 775639 | p.Ile948Val | missense_variant | 1.0 | clofazimine | Not assoc w R |
bedaquiline | Not assoc w R - Interim | |||||
mmpL5 | 775885 | p.Ile866Leu | missense_variant | 0.17 | clofazimine | |
bedaquiline | ||||||
mmpL5 | 775909 | p.Leu858Phe | missense_variant | 0.17 | clofazimine | |
bedaquiline | ||||||
mmpL5 | 775915 | p.Ala856Ser | missense_variant | 0.19 | clofazimine | |
bedaquiline | ||||||
mmpL5 | 775937 | c.2544G>C | synonymous_variant | 0.16 | clofazimine | |
bedaquiline | ||||||
mmpL5 | 776100 | p.Thr794Ile | missense_variant | 0.87 | clofazimine | Not assoc w R |
bedaquiline | Not assoc w R - Interim | |||||
mmpL5 | 776182 | p.Asp767Asn | missense_variant | 0.81 | clofazimine | Not assoc w R |
bedaquiline | Not assoc w R | |||||
mmpS5 | 778979 | c.-74G>T | upstream_gene_variant | 0.85 | clofazimine | Uncertain significance |
bedaquiline | Not assoc w R - Interim | |||||
mmpS5 | 779615 | c.-710C>G | upstream_gene_variant | 0.86 | clofazimine | |
bedaquiline | ||||||
rpsL | 781395 | c.-165T>C | upstream_gene_variant | 1.0 | streptomycin | Not assoc w R |
rpsL | 781760 | c.201T>C | synonymous_variant | 0.14 | streptomycin | |
rpsL | 781763 | c.204C>G | synonymous_variant | 0.15 | streptomycin | |
rpsL | 781811 | c.252C>T | synonymous_variant | 0.13 | streptomycin | |
rplC | 800516 | c.-293G>T | upstream_gene_variant | 0.15 | linezolid | |
rplC | 800537 | c.-272C>T | upstream_gene_variant | 0.19 | linezolid | |
rplC | 800546 | c.-263T>G | upstream_gene_variant | 0.22 | linezolid | |
rplC | 800567 | c.-242A>G | upstream_gene_variant | 0.21 | linezolid | |
rplC | 800582 | c.-227C>G | upstream_gene_variant | 0.23 | linezolid | |
rplC | 800612 | c.-197A>G | upstream_gene_variant | 0.22 | linezolid | |
rplC | 800618 | c.-191T>C | upstream_gene_variant | 0.22 | linezolid | |
rplC | 800648 | c.-161A>C | upstream_gene_variant | 0.2 | linezolid | |
rplC | 800654 | c.-155T>C | upstream_gene_variant | 0.19 | linezolid | |
Rv1129c | 1254562 | c.-28T>C | upstream_gene_variant | 0.89 | moxifloxacin | Not assoc w R |
levofloxacin | Not assoc w R | |||||
rifampicin | Not assoc w R | |||||
isoniazid | Not assoc w R | |||||
fbiC | 1303785 | c.855G>A | synonymous_variant | 0.15 | clofazimine | |
pretomanid | ||||||
delamanid | ||||||
fbiC | 1303789 | p.Ile287Val | missense_variant | 0.15 | clofazimine | |
pretomanid | ||||||
delamanid | ||||||
fbiC | 1303818 | c.888C>G | synonymous_variant | 0.16 | clofazimine | |
pretomanid | ||||||
delamanid | ||||||
fbiC | 1304853 | c.1923C>G | synonymous_variant | 0.15 | clofazimine | Not assoc w R - Interim |
pretomanid | ||||||
delamanid | Not assoc w R - Interim | |||||
Rv1258c | 1406760 | c.580_581insC | frameshift_variant | 0.94 | streptomycin | Uncertain significance |
isoniazid | Uncertain significance | |||||
pyrazinamide | Uncertain significance | |||||
rrs | 1471659 | n.-187C>T | upstream_gene_variant | 1.0 | streptomycin | |
kanamycin | ||||||
capreomycin | ||||||
amikacin | ||||||
rrs | 1472489 | n.644A>G | non_coding_transcript_exon_variant | 0.35 | streptomycin | Uncertain significance |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1473105 | n.1260G>A | non_coding_transcript_exon_variant | 0.31 | streptomycin | |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1473123 | n.1278delAinsTT | non_coding_transcript_exon_variant | 0.28 | streptomycin | |
kanamycin | ||||||
capreomycin | ||||||
amikacin | ||||||
rrs | 1473290 | n.1445delCinsTT | non_coding_transcript_exon_variant | 0.29 | streptomycin | |
kanamycin | ||||||
capreomycin | ||||||
amikacin | ||||||
rrl | 1473758 | n.101G>T | non_coding_transcript_exon_variant | 0.28 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1473806 | n.149C>T | non_coding_transcript_exon_variant | 0.31 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1473815 | n.158T>C | non_coding_transcript_exon_variant | 0.29 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1473876 | n.219G>A | non_coding_transcript_exon_variant | 0.15 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474717 | n.1060A>T | non_coding_transcript_exon_variant | 0.32 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474794 | n.1137C>T | non_coding_transcript_exon_variant | 0.33 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474812 | n.1155G>A | non_coding_transcript_exon_variant | 0.34 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474831 | n.1174A>G | non_coding_transcript_exon_variant | 0.32 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1474991 | n.1334T>C | non_coding_transcript_exon_variant | 0.2 | capreomycin | |
linezolid | ||||||
rrl | 1474995 | n.1338T>G | non_coding_transcript_exon_variant | 0.21 | capreomycin | |
linezolid | ||||||
rrl | 1475006 | n.1349A>G | non_coding_transcript_exon_variant | 0.22 | capreomycin | |
linezolid | ||||||
rrl | 1475027 | n.1370G>T | non_coding_transcript_exon_variant | 0.21 | capreomycin | |
linezolid | ||||||
rrl | 1475028 | n.1371G>T | non_coding_transcript_exon_variant | 0.21 | capreomycin | |
linezolid | ||||||
rrl | 1475061 | n.1404C>T | non_coding_transcript_exon_variant | 0.28 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1475088 | n.1431A>T | non_coding_transcript_exon_variant | 0.31 | capreomycin | |
linezolid | ||||||
rrl | 1475206 | n.1549C>T | non_coding_transcript_exon_variant | 0.25 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1475209 | n.1552G>A | non_coding_transcript_exon_variant | 0.28 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1475252 | n.1595C>T | non_coding_transcript_exon_variant | 0.25 | capreomycin | |
linezolid | ||||||
rrl | 1475266 | n.1609T>C | non_coding_transcript_exon_variant | 0.23 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1475267 | n.1610G>A | non_coding_transcript_exon_variant | 0.23 | capreomycin | |
linezolid | ||||||
rrl | 1475270 | n.1613G>A | non_coding_transcript_exon_variant | 0.23 | capreomycin | |
linezolid | ||||||
rrl | 1475275 | n.1618C>T | non_coding_transcript_exon_variant | 0.23 | capreomycin | |
linezolid | ||||||
rrl | 1475276 | n.1619T>C | non_coding_transcript_exon_variant | 0.24 | capreomycin | |
linezolid | ||||||
rrl | 1475289 | n.1632G>A | non_coding_transcript_exon_variant | 0.24 | capreomycin | |
linezolid | ||||||
rrl | 1475291 | n.1634A>C | non_coding_transcript_exon_variant | 0.24 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1475313 | n.1656G>A | non_coding_transcript_exon_variant | 0.25 | capreomycin | |
linezolid | ||||||
rrl | 1475315 | n.1658A>T | non_coding_transcript_exon_variant | 0.25 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1475355 | n.1698C>T | non_coding_transcript_exon_variant | 0.19 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1475369 | n.1712G>C | non_coding_transcript_exon_variant | 0.15 | capreomycin | |
linezolid | ||||||
rrl | 1475532 | n.1875A>G | non_coding_transcript_exon_variant | 0.26 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1475573 | n.1916G>A | non_coding_transcript_exon_variant | 0.24 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1475604 | n.1947A>C | non_coding_transcript_exon_variant | 0.18 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1475606 | n.1949T>C | non_coding_transcript_exon_variant | 0.18 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1475608 | n.1951T>C | non_coding_transcript_exon_variant | 0.17 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1475617 | n.1960C>G | non_coding_transcript_exon_variant | 0.17 | capreomycin | |
linezolid | ||||||
rrl | 1475625 | n.1968G>C | non_coding_transcript_exon_variant | 0.18 | capreomycin | |
linezolid | ||||||
rrl | 1475637 | n.1980T>G | non_coding_transcript_exon_variant | 0.18 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1475655 | n.1998T>C | non_coding_transcript_exon_variant | 0.19 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1475659 | n.2002G>A | non_coding_transcript_exon_variant | 0.2 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1475758 | n.2104delC | non_coding_transcript_exon_variant | 0.48 | capreomycin | |
linezolid | ||||||
rrl | 1475765 | n.2111delG | non_coding_transcript_exon_variant | 0.5 | capreomycin | |
linezolid | ||||||
rrl | 1475883 | n.2226A>G | non_coding_transcript_exon_variant | 0.24 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1475988 | n.2331A>G | non_coding_transcript_exon_variant | 0.2 | capreomycin | Not assoc w R |
linezolid | Uncertain significance | |||||
rrl | 1476033 | n.2376T>C | non_coding_transcript_exon_variant | 0.19 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1476035 | n.2378G>A | non_coding_transcript_exon_variant | 0.19 | capreomycin | |
linezolid | ||||||
rrl | 1476086 | n.2429G>A | non_coding_transcript_exon_variant | 0.19 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476089 | n.2432T>C | non_coding_transcript_exon_variant | 0.19 | capreomycin | |
linezolid | ||||||
rrl | 1476095 | n.2438C>G | non_coding_transcript_exon_variant | 0.18 | capreomycin | |
linezolid | ||||||
rrl | 1476103 | n.2446C>G | non_coding_transcript_exon_variant | 0.19 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1476105 | n.2448G>A | non_coding_transcript_exon_variant | 0.19 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1476106 | n.2449A>T | non_coding_transcript_exon_variant | 0.19 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1476110 | n.2453G>C | non_coding_transcript_exon_variant | 0.18 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1476115 | n.2458T>C | non_coding_transcript_exon_variant | 0.18 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476117 | n.2460G>C | non_coding_transcript_exon_variant | 0.18 | capreomycin | |
linezolid | ||||||
rrl | 1476131 | n.2474C>T | non_coding_transcript_exon_variant | 0.23 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476214 | n.2557G>T | non_coding_transcript_exon_variant | 0.27 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476215 | n.2558C>T | non_coding_transcript_exon_variant | 0.29 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476251 | n.2594T>C | non_coding_transcript_exon_variant | 0.34 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476583 | n.2926G>C | non_coding_transcript_exon_variant | 0.25 | capreomycin | |
linezolid | ||||||
rrl | 1476597 | n.2940G>A | non_coding_transcript_exon_variant | 0.22 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1476628 | n.2971T>A | non_coding_transcript_exon_variant | 0.2 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
inhA | 1673664 | c.-538A>C | upstream_gene_variant | 0.14 | ethionamide | |
isoniazid | ||||||
inhA | 1673712 | c.-490A>G | upstream_gene_variant | 0.15 | ethionamide | |
isoniazid | ||||||
inhA | 1673713 | c.-489T>G | upstream_gene_variant | 0.15 | ethionamide | |
isoniazid | Uncertain significance | |||||
inhA | 1673730 | c.-472C>G | upstream_gene_variant | 0.14 | ethionamide | |
isoniazid | ||||||
inhA | 1673838 | c.-364T>C | upstream_gene_variant | 0.13 | ethionamide | |
isoniazid | ||||||
inhA | 1673841 | c.-361A>G | upstream_gene_variant | 0.15 | ethionamide | |
isoniazid | ||||||
inhA | 1673847 | c.-355A>C | upstream_gene_variant | 0.15 | ethionamide | |
isoniazid | ||||||
inhA | 1673853 | c.-349A>C | upstream_gene_variant | 0.16 | ethionamide | |
isoniazid | ||||||
inhA | 1673856 | c.-346T>G | upstream_gene_variant | 0.16 | ethionamide | |
isoniazid | ||||||
fabG1 | 1673870 | p.Ser144Thr | missense_variant | 0.18 | ethionamide | |
isoniazid | ||||||
inhA | 1673901 | c.-301A>G | upstream_gene_variant | 0.19 | ethionamide | |
isoniazid | ||||||
inhA | 1673904 | c.-298C>G | upstream_gene_variant | 0.21 | ethionamide | |
isoniazid | ||||||
inhA | 1673916 | c.-286A>C | upstream_gene_variant | 0.22 | ethionamide | |
isoniazid | ||||||
inhA | 1673919 | c.-283G>C | upstream_gene_variant | 0.2 | ethionamide | |
isoniazid | ||||||
inhA | 1673922 | c.-280T>C | upstream_gene_variant | 0.19 | ethionamide | |
isoniazid | ||||||
inhA | 1673934 | c.-268C>T | upstream_gene_variant | 0.23 | ethionamide | |
isoniazid | ||||||
inhA | 1673946 | c.-256C>G | upstream_gene_variant | 0.22 | ethionamide | |
isoniazid | ||||||
fabG1 | 1673950 | p.Leu171Met | missense_variant | 0.22 | ethionamide | |
isoniazid | ||||||
inhA | 1673961 | c.-241A>C | upstream_gene_variant | 0.24 | ethionamide | |
isoniazid | ||||||
inhA | 1673973 | c.-229G>C | upstream_gene_variant | 0.23 | ethionamide | |
isoniazid | Uncertain significance | |||||
inhA | 1673976 | c.-226T>C | upstream_gene_variant | 0.24 | ethionamide | |
isoniazid | ||||||
inhA | 1673985 | c.-217C>G | upstream_gene_variant | 0.23 | ethionamide | |
isoniazid | ||||||
inhA | 1674006 | c.-196T>C | upstream_gene_variant | 0.21 | ethionamide | |
isoniazid | ||||||
fabG1 | 1674017 | p.Ala193Gly | missense_variant | 0.2 | ethionamide | |
isoniazid | ||||||
inhA | 1674024 | c.-178T>C | upstream_gene_variant | 0.18 | ethionamide | |
isoniazid | ||||||
inhA | 1674033 | c.-169T>C | upstream_gene_variant | 0.18 | ethionamide | |
isoniazid | ||||||
fabG1 | 1674037 | p.Gln200Glu | missense_variant | 0.18 | ethionamide | |
isoniazid | ||||||
inhA | 1674051 | c.-151A>G | upstream_gene_variant | 0.14 | ethionamide | |
isoniazid | ||||||
inhA | 1674714 | c.513C>G | synonymous_variant | 0.14 | ethionamide | |
isoniazid | ||||||
inhA | 1674718 | c.517A>C | synonymous_variant | 0.15 | ethionamide | |
isoniazid | ||||||
inhA | 1674729 | c.528G>C | synonymous_variant | 0.18 | ethionamide | |
isoniazid | ||||||
inhA | 1674735 | c.534G>A | synonymous_variant | 0.18 | ethionamide | |
isoniazid | ||||||
inhA | 1674738 | c.537C>G | synonymous_variant | 0.17 | ethionamide | |
isoniazid | ||||||
inhA | 1674743 | p.Lys181Thr | missense_variant | 0.15 | ethionamide | |
isoniazid | ||||||
inhA | 1674750 | c.549T>C | synonymous_variant | 0.16 | ethionamide | |
isoniazid | ||||||
inhA | 1674756 | c.555T>C | synonymous_variant | 0.17 | ethionamide | Not assoc w R - Interim |
isoniazid | Not assoc w R - Interim | |||||
inhA | 1674765 | c.564C>T | synonymous_variant | 0.17 | ethionamide | |
isoniazid | ||||||
inhA | 1674774 | c.573A>G | synonymous_variant | 0.17 | ethionamide | |
isoniazid | ||||||
inhA | 1674777 | c.576C>A | synonymous_variant | 0.16 | ethionamide | |
isoniazid | ||||||
inhA | 1674780 | c.579T>G | synonymous_variant | 0.16 | ethionamide | |
isoniazid | ||||||
inhA | 1674801 | c.600T>C | synonymous_variant | 0.15 | ethionamide | |
isoniazid | ||||||
inhA | 1674825 | c.624C>T | synonymous_variant | 0.13 | ethionamide | |
isoniazid | Not assoc w R - Interim | |||||
rpsA | 1833589 | c.48A>T | synonymous_variant | 0.15 | pyrazinamide | |
rpsA | 1833595 | c.54T>G | synonymous_variant | 0.17 | pyrazinamide | |
rpsA | 1833646 | c.105T>C | synonymous_variant | 0.27 | pyrazinamide | Not assoc w R - Interim |
rpsA | 1833667 | c.126C>G | synonymous_variant | 0.28 | pyrazinamide | |
rpsA | 1833724 | c.183C>G | synonymous_variant | 0.24 | pyrazinamide | |
rpsA | 1833727 | c.186G>C | synonymous_variant | 0.25 | pyrazinamide | |
rpsA | 1833742 | c.201A>G | synonymous_variant | 0.22 | pyrazinamide | |
rpsA | 1833745 | c.204G>C | synonymous_variant | 0.23 | pyrazinamide | |
rpsA | 1833748 | c.207C>G | synonymous_variant | 0.23 | pyrazinamide | |
rpsA | 1833778 | c.237C>T | synonymous_variant | 0.16 | pyrazinamide | |
rpsA | 1833781 | c.240T>C | synonymous_variant | 0.16 | pyrazinamide | |
rpsA | 1834177 | c.636A>C | synonymous_variant | 0.92 | pyrazinamide | Not assoc w R - Interim |
rpsA | 1834366 | c.825A>G | synonymous_variant | 0.13 | pyrazinamide | Not assoc w R - Interim |
rpsA | 1834369 | c.828C>G | synonymous_variant | 0.13 | pyrazinamide | |
rpsA | 1834375 | c.834G>A | synonymous_variant | 0.13 | pyrazinamide | |
rpsA | 1834411 | c.870T>C | synonymous_variant | 0.16 | pyrazinamide | |
rpsA | 1834417 | c.876G>C | synonymous_variant | 0.17 | pyrazinamide | |
rpsA | 1834423 | c.882G>C | synonymous_variant | 0.15 | pyrazinamide | |
rpsA | 1834451 | c.910T>C | synonymous_variant | 0.15 | pyrazinamide | |
rpsA | 1834456 | c.915T>G | synonymous_variant | 0.14 | pyrazinamide | |
rpsA | 1834459 | c.918G>A | synonymous_variant | 0.14 | pyrazinamide | |
rpsA | 1834468 | c.927A>G | synonymous_variant | 0.14 | pyrazinamide | |
rpsA | 1834525 | c.984G>A | synonymous_variant | 0.15 | pyrazinamide | |
rpsA | 1834528 | c.987T>C | synonymous_variant | 0.17 | pyrazinamide | |
rpsA | 1834546 | c.1005T>C | synonymous_variant | 0.21 | pyrazinamide | |
rpsA | 1834555 | c.1014T>C | synonymous_variant | 0.22 | pyrazinamide | |
rpsA | 1834609 | c.1068T>C | synonymous_variant | 0.21 | pyrazinamide | |
rpsA | 1834633 | c.1092A>G | synonymous_variant | 0.21 | pyrazinamide | |
rpsA | 1834639 | c.1098T>C | synonymous_variant | 0.23 | pyrazinamide | |
rpsA | 1834669 | c.1128G>C | synonymous_variant | 0.22 | pyrazinamide | |
rpsA | 1834690 | c.1149T>C | synonymous_variant | 0.17 | pyrazinamide | |
rpsA | 1834732 | c.1191T>C | synonymous_variant | 0.15 | pyrazinamide | |
tsnR | 1853370 | c.-236_-234delGCAinsTC | upstream_gene_variant | 0.17 | linezolid | |
tsnR | 1853387 | c.-219T>G | upstream_gene_variant | 0.16 | linezolid | |
tsnR | 1853390 | c.-216G>C | upstream_gene_variant | 0.16 | linezolid | |
tsnR | 1853394 | c.-212_-211delCTinsGC | upstream_gene_variant | 0.15 | linezolid | |
tsnR | 1853408 | c.-198C>G | upstream_gene_variant | 0.15 | linezolid | |
tsnR | 1853420 | c.-186T>G | upstream_gene_variant | 0.22 | linezolid | |
tsnR | 1853429 | c.-177G>C | upstream_gene_variant | 0.19 | linezolid | |
tsnR | 1853432 | c.-174G>C | upstream_gene_variant | 0.18 | linezolid | |
tsnR | 1853438 | c.-168C>G | upstream_gene_variant | 0.18 | linezolid | |
tsnR | 1853444 | c.-162C>G | upstream_gene_variant | 0.17 | linezolid | |
tsnR | 1853459 | c.-147G>C | upstream_gene_variant | 0.15 | linezolid | |
tsnR | 1853465 | c.-141C>T | upstream_gene_variant | 0.14 | linezolid | |
tsnR | 1854300 | p.Leu232Pro | missense_variant | 1.0 | linezolid | Not assoc w R |
tlyA | 1917972 | c.33A>G | synonymous_variant | 1.0 | capreomycin | Not assoc w R |
katG | 2154113 | p.Thr667Pro | missense_variant | 0.92 | isoniazid | Uncertain significance |
katG | 2154724 | p.Arg463Leu | missense_variant | 0.83 | isoniazid | Not assoc w R |
PPE35 | 2167926 | p.Leu896Ser | missense_variant | 0.87 | pyrazinamide | Not assoc w R |
Rv1979c | 2223293 | c.-129A>G | upstream_gene_variant | 1.0 | clofazimine | Not assoc w R |
bedaquiline | Not assoc w R - Interim | |||||
kasA | 2517941 | c.-174C>G | upstream_gene_variant | 0.26 | isoniazid | |
kasA | 2517974 | c.-141T>C | upstream_gene_variant | 0.22 | isoniazid | |
kasA | 2517989 | c.-126T>G | upstream_gene_variant | 0.22 | isoniazid | |
kasA | 2518076 | c.-39C>T | upstream_gene_variant | 0.15 | isoniazid | |
kasA | 2518684 | c.570C>T | synonymous_variant | 0.15 | isoniazid | |
kasA | 2518696 | c.582C>G | synonymous_variant | 0.16 | isoniazid | |
kasA | 2518705 | c.591T>C | synonymous_variant | 0.19 | isoniazid | |
kasA | 2518714 | c.600A>C | synonymous_variant | 0.18 | isoniazid | |
kasA | 2518732 | c.618C>G | synonymous_variant | 0.2 | isoniazid | |
kasA | 2518741 | c.627G>T | synonymous_variant | 0.24 | isoniazid | |
kasA | 2518747 | c.633C>G | synonymous_variant | 0.26 | isoniazid | |
kasA | 2518783 | c.669T>G | synonymous_variant | 0.25 | isoniazid | |
kasA | 2518789 | c.675G>C | synonymous_variant | 0.21 | isoniazid | |
kasA | 2518792 | c.678C>G | synonymous_variant | 0.18 | isoniazid | |
kasA | 2518795 | c.681C>G | synonymous_variant | 0.17 | isoniazid | |
kasA | 2518798 | c.684G>T | synonymous_variant | 0.16 | isoniazid | |
kasA | 2518825 | c.711T>C | synonymous_variant | 0.2 | isoniazid | |
kasA | 2518828 | c.714G>C | synonymous_variant | 0.19 | isoniazid | |
kasA | 2518864 | c.750G>C | synonymous_variant | 0.16 | isoniazid | |
kasA | 2518879 | c.765A>G | synonymous_variant | 0.16 | isoniazid | |
Rv2477c | 2782978 | c.1065C>G | synonymous_variant | 0.16 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
kanamycin | ||||||
rifampicin | ||||||
amikacin | ||||||
Rv2477c | 2782984 | c.1059T>C | synonymous_variant | 0.16 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
kanamycin | ||||||
rifampicin | ||||||
amikacin | ||||||
Rv2477c | 2783040 | p.Ala335Thr | missense_variant | 0.14 | ethambutol | Uncertain significance |
moxifloxacin | Uncertain significance | |||||
streptomycin | Uncertain significance | |||||
levofloxacin | Uncertain significance | |||||
kanamycin | Uncertain significance | |||||
rifampicin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
Rv2681 | 2997005 | c.267C>T | synonymous_variant | 0.14 | capreomycin | |
Rv2681 | 2997013 | p.Gly92Ala | missense_variant | 0.14 | capreomycin | |
Rv2681 | 2997028 | p.Val97Ala | missense_variant | 0.14 | capreomycin | |
Rv2681 | 2997035 | c.297G>A | synonymous_variant | 0.15 | capreomycin | Not assoc w R - Interim |
Rv2681 | 2997053 | c.315C>G | synonymous_variant | 0.14 | capreomycin | |
Rv2681 | 2997054 | p.Ser106Asp | missense_variant | 0.14 | capreomycin | |
Rv2681 | 2997060 | p.Asn108Asp | missense_variant | 0.14 | capreomycin | |
Rv2681 | 2997065 | c.327G>A | synonymous_variant | 0.14 | capreomycin | |
Rv2681 | 2997086 | c.348T>C | synonymous_variant | 0.13 | capreomycin | |
ald | 3086788 | c.-32T>C | upstream_gene_variant | 1.0 | cycloserine | |
Rv3236c | 3612813 | p.Thr102Ala | missense_variant | 0.85 | pyrazinamide | Not assoc w R - Interim |
mtrB | 3625065 | p.Met517Leu | missense_variant | 1.0 | bedaquiline | Uncertain significance |
rifampicin | Not assoc w R | |||||
mtrB | 3626562 | p.Pro18Ser | missense_variant | 0.85 | bedaquiline | Uncertain significance |
rifampicin | Not assoc w R | |||||
mtrB | 3626987 | c.-374C>G | upstream_gene_variant | 0.15 | bedaquiline | |
rifampicin | ||||||
mtrB | 3626999 | c.-386G>C | upstream_gene_variant | 0.17 | bedaquiline | |
rifampicin | ||||||
mtrB | 3627005 | c.-392G>C | upstream_gene_variant | 0.17 | bedaquiline | |
rifampicin | ||||||
mtrB | 3627008 | c.-395G>C | upstream_gene_variant | 0.17 | bedaquiline | |
rifampicin | ||||||
mtrB | 3627011 | c.-398T>C | upstream_gene_variant | 0.17 | bedaquiline | |
rifampicin | ||||||
rpoA | 3877587 | c.921A>G | synonymous_variant | 0.15 | rifampicin | Not assoc w R - Interim |
rpoA | 3877593 | c.915C>T | synonymous_variant | 0.16 | rifampicin | Not assoc w R - Interim |
rpoA | 3877613 | p.Ile299Val | missense_variant | 0.21 | rifampicin | |
rpoA | 3877638 | c.870T>G | synonymous_variant | 0.18 | rifampicin | |
rpoA | 3877656 | c.852T>C | synonymous_variant | 0.17 | rifampicin | Not assoc w R - Interim |
rpoA | 3877668 | c.840A>G | synonymous_variant | 0.19 | rifampicin | |
rpoA | 3877677 | p.Ala277Ser | missense_variant | 0.21 | rifampicin | |
rpoA | 3877686 | c.822A>G | synonymous_variant | 0.24 | rifampicin | Not assoc w R - Interim |
rpoA | 3877692 | c.816G>C | synonymous_variant | 0.23 | rifampicin | Not assoc w R - Interim |
rpoA | 3877704 | c.804G>C | synonymous_variant | 0.18 | rifampicin | |
rpoA | 3877737 | c.771G>C | synonymous_variant | 0.15 | rifampicin | |
rpoA | 3877818 | c.690A>G | synonymous_variant | 0.16 | rifampicin | Not assoc w R - Interim |
rpoA | 3877841 | c.667C>A | synonymous_variant | 0.15 | rifampicin | Not assoc w R - Interim |
rpoA | 3877875 | c.633T>G | synonymous_variant | 0.16 | rifampicin | |
rpoA | 3877893 | c.615C>T | synonymous_variant | 0.16 | rifampicin | Not assoc w R - Interim |
rpoA | 3877896 | c.612G>C | synonymous_variant | 0.16 | rifampicin | |
rpoA | 3877962 | c.546G>T | synonymous_variant | 0.2 | rifampicin | Not assoc w R - Interim |
rpoA | 3877986 | c.522G>C | synonymous_variant | 0.22 | rifampicin | |
rpoA | 3877989 | c.519A>G | synonymous_variant | 0.2 | rifampicin | Not assoc w R - Interim |
rpoA | 3878001 | c.507A>G | synonymous_variant | 0.18 | rifampicin | Not assoc w R - Interim |
rpoA | 3878019 | c.489A>G | synonymous_variant | 0.2 | rifampicin | |
rpoA | 3878022 | c.486T>C | synonymous_variant | 0.2 | rifampicin | |
rpoA | 3878028 | c.480G>C | synonymous_variant | 0.2 | rifampicin | |
rpoA | 3878031 | c.477T>C | synonymous_variant | 0.2 | rifampicin | |
rpoA | 3878040 | c.468T>C | synonymous_variant | 0.22 | rifampicin | Not assoc w R - Interim |
rpoA | 3878046 | c.462T>G | synonymous_variant | 0.21 | rifampicin | |
rpoA | 3878049 | c.459G>C | synonymous_variant | 0.22 | rifampicin | |
rpoA | 3878055 | c.453A>G | synonymous_variant | 0.26 | rifampicin | |
rpoA | 3878067 | c.441C>G | synonymous_variant | 0.25 | rifampicin | |
rpoA | 3878070 | c.438T>C | synonymous_variant | 0.26 | rifampicin | |
rpoA | 3878082 | c.426T>C | synonymous_variant | 0.29 | rifampicin | |
rpoA | 3878103 | c.405A>G | synonymous_variant | 0.25 | rifampicin | |
rpoA | 3878106 | c.402G>C | synonymous_variant | 0.24 | rifampicin | |
rpoA | 3878118 | c.390T>C | synonymous_variant | 0.25 | rifampicin | |
rpoA | 3878130 | c.378C>G | synonymous_variant | 0.22 | rifampicin | |
rpoA | 3878157 | c.351C>G | synonymous_variant | 0.24 | rifampicin | |
rpoA | 3878160 | c.348C>G | synonymous_variant | 0.26 | rifampicin | Not assoc w R - Interim |
rpoA | 3878187 | c.321C>G | synonymous_variant | 0.27 | rifampicin | |
rpoA | 3878193 | c.315T>G | synonymous_variant | 0.24 | rifampicin | |
rpoA | 3878205 | c.303T>C | synonymous_variant | 0.22 | rifampicin | Not assoc w R - Interim |
rpoA | 3878217 | c.291A>G | synonymous_variant | 0.23 | rifampicin | Not assoc w R - Interim |
rpoA | 3878232 | c.276G>C | synonymous_variant | 0.2 | rifampicin | |
rpoA | 3878235 | c.273G>A | synonymous_variant | 0.18 | rifampicin | Not assoc w R - Interim |
rpoA | 3878247 | c.261G>C | synonymous_variant | 0.16 | rifampicin | |
rpoA | 3878264 | p.Ser82Gly | missense_variant | 0.14 | rifampicin | |
rpoA | 3878283 | p.Glu75Asp | missense_variant | 0.13 | rifampicin | Uncertain significance |
rpoA | 3878292 | c.216T>C | synonymous_variant | 0.15 | rifampicin | Not assoc w R - Interim |
rpoA | 3878304 | c.204G>C | synonymous_variant | 0.14 | rifampicin | |
rpoA | 3878313 | c.195G>C | synonymous_variant | 0.15 | rifampicin | Not assoc w R - Interim |
rpoA | 3878322 | c.186A>G | synonymous_variant | 0.17 | rifampicin | Not assoc w R - Interim |
rpoA | 3878331 | c.177A>G | synonymous_variant | 0.17 | rifampicin | Not assoc w R - Interim |
rpoA | 3878334 | c.174T>C | synonymous_variant | 0.17 | rifampicin | Not assoc w R - Interim |
rpoA | 3878337 | c.171T>C | synonymous_variant | 0.17 | rifampicin | Not assoc w R - Interim |
rpoA | 3878346 | c.162T>C | synonymous_variant | 0.22 | rifampicin | |
rpoA | 3878364 | c.144A>C | synonymous_variant | 0.22 | rifampicin | |
rpoA | 3878367 | c.141C>G | synonymous_variant | 0.22 | rifampicin | |
rpoA | 3878370 | c.138T>C | synonymous_variant | 0.22 | rifampicin | |
rpoA | 3878385 | c.123C>G | synonymous_variant | 0.23 | rifampicin | |
rpoA | 3878391 | c.117T>G | synonymous_variant | 0.23 | rifampicin | Not assoc w R - Interim |
rpoA | 3878415 | c.93C>T | synonymous_variant | 0.22 | rifampicin | |
rpoA | 3878424 | c.84G>C | synonymous_variant | 0.17 | rifampicin | |
rpoA | 3878436 | c.72A>G | synonymous_variant | 0.16 | rifampicin | |
rpoA | 3878442 | c.66G>C | synonymous_variant | 0.16 | rifampicin | |
rpoA | 3878454 | c.54A>G | synonymous_variant | 0.16 | rifampicin | |
rpoA | 3878458 | p.Asn17Thr | missense_variant | 0.15 | rifampicin | |
rpoA | 3878698 | c.-191A>G | upstream_gene_variant | 0.17 | rifampicin | |
rpoA | 3878701 | c.-194C>G | upstream_gene_variant | 0.18 | rifampicin | |
rpoA | 3878725 | c.-218A>G | upstream_gene_variant | 0.2 | rifampicin | |
rpoA | 3878742 | c.-235G>A | upstream_gene_variant | 0.27 | rifampicin | |
rpoA | 3878746 | c.-239A>G | upstream_gene_variant | 0.28 | rifampicin | Uncertain significance |
rpoA | 3878749 | c.-242G>C | upstream_gene_variant | 0.28 | rifampicin | |
rpoA | 3878758 | c.-251G>C | upstream_gene_variant | 0.26 | rifampicin | |
rpoA | 3878764 | c.-257A>G | upstream_gene_variant | 0.3 | rifampicin | |
rpoA | 3878785 | c.-278T>C | upstream_gene_variant | 0.35 | rifampicin | |
rpoA | 3878788 | c.-281G>C | upstream_gene_variant | 0.36 | rifampicin | Uncertain significance |
rpoA | 3878791 | c.-284C>T | upstream_gene_variant | 0.36 | rifampicin | Uncertain significance |
rpoA | 3878806 | c.-299C>G | upstream_gene_variant | 0.3 | rifampicin | |
rpoA | 3878809 | c.-302T>C | upstream_gene_variant | 0.32 | rifampicin | |
rpoA | 3878824 | c.-318_-317delCGinsGC | upstream_gene_variant | 0.3 | rifampicin | |
rpoA | 3878833 | c.-326C>G | upstream_gene_variant | 0.26 | rifampicin | |
rpoA | 3878837 | c.-331_-330delAAinsTC | upstream_gene_variant | 0.22 | rifampicin | |
rpoA | 3878853 | c.-346G>A | upstream_gene_variant | 0.22 | rifampicin | |
clpC1 | 4038653 | c.2052C>T | synonymous_variant | 0.14 | pyrazinamide | |
clpC1 | 4038695 | c.2010C>G | synonymous_variant | 0.13 | pyrazinamide | |
clpC1 | 4038713 | c.1992T>C | synonymous_variant | 0.14 | pyrazinamide | |
clpC1 | 4038755 | c.1950G>C | synonymous_variant | 0.15 | pyrazinamide | |
clpC1 | 4038764 | c.1941C>G | synonymous_variant | 0.14 | pyrazinamide | |
clpC1 | 4038767 | c.1938G>T | synonymous_variant | 0.14 | pyrazinamide | |
clpC1 | 4038790 | c.1915C>T | synonymous_variant | 0.14 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4038812 | c.1893T>C | synonymous_variant | 0.22 | pyrazinamide | |
clpC1 | 4038821 | c.1884G>A | synonymous_variant | 0.24 | pyrazinamide | |
clpC1 | 4038878 | c.1827A>G | synonymous_variant | 0.21 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4038908 | c.1797C>G | synonymous_variant | 0.25 | pyrazinamide | |
clpC1 | 4038914 | c.1791G>C | synonymous_variant | 0.26 | pyrazinamide | |
clpC1 | 4038923 | c.1782A>G | synonymous_variant | 0.26 | pyrazinamide | |
clpC1 | 4038953 | c.1752A>G | synonymous_variant | 0.18 | pyrazinamide | |
clpC1 | 4038956 | c.1749T>C | synonymous_variant | 0.19 | pyrazinamide | |
clpC1 | 4038965 | c.1740T>C | synonymous_variant | 0.2 | pyrazinamide | |
clpC1 | 4038971 | c.1734T>C | synonymous_variant | 0.19 | pyrazinamide | |
clpC1 | 4038974 | c.1731T>C | synonymous_variant | 0.19 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4038997 | c.1708T>C | synonymous_variant | 0.19 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4039022 | c.1683A>G | synonymous_variant | 0.16 | pyrazinamide | |
clpC1 | 4040695 | c.10C>A | synonymous_variant | 0.14 | pyrazinamide | |
clpC1 | 4040711 | c.-7G>A | upstream_gene_variant | 0.14 | pyrazinamide | |
glpK | 4138514 | c.1242A>G | synonymous_variant | 0.15 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
rifampicin | ||||||
isoniazid | ||||||
glpK | 4138535 | c.1221T>C | synonymous_variant | 0.18 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
rifampicin | ||||||
isoniazid | ||||||
glpK | 4138568 | c.1188A>G | synonymous_variant | 0.2 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
rifampicin | ||||||
isoniazid | ||||||
glpK | 4138574 | c.1182G>C | synonymous_variant | 0.19 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
rifampicin | ||||||
isoniazid | ||||||
glpK | 4138580 | c.1176C>T | synonymous_variant | 0.19 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
rifampicin | ||||||
isoniazid | ||||||
glpK | 4138583 | c.1173G>C | synonymous_variant | 0.19 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
rifampicin | ||||||
isoniazid | ||||||
glpK | 4138604 | p.Leu384Phe | missense_variant | 0.15 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
rifampicin | ||||||
isoniazid | ||||||
glpK | 4138607 | c.1149G>T | synonymous_variant | 0.14 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
rifampicin | ||||||
isoniazid | ||||||
glpK | 4138661 | c.1095T>C | synonymous_variant | 0.15 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
rifampicin | ||||||
isoniazid | ||||||
glpK | 4138695 | p.Pro354Asp | missense_variant | 0.16 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
rifampicin | ||||||
isoniazid | ||||||
glpK | 4138703 | c.1053C>T | synonymous_variant | 0.18 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
rifampicin | ||||||
isoniazid | ||||||
glpK | 4138712 | c.1042_1044delGCGinsTA | frameshift_variant&missense_variant | 0.19 | ethambutol | Uncertain significance |
moxifloxacin | Uncertain significance | |||||
streptomycin | Uncertain significance | |||||
levofloxacin | Uncertain significance | |||||
rifampicin | Uncertain significance | |||||
isoniazid | Uncertain significance | |||||
glpK | 4138718 | c.1038T>C | synonymous_variant | 0.18 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
rifampicin | ||||||
isoniazid | ||||||
glpK | 4138724 | c.1032A>G | synonymous_variant | 0.19 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
rifampicin | ||||||
isoniazid | ||||||
glpK | 4138745 | c.1011G>C | synonymous_variant | 0.26 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
rifampicin | ||||||
isoniazid | ||||||
glpK | 4138751 | c.1005T>C | synonymous_variant | 0.25 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
rifampicin | ||||||
isoniazid | ||||||
glpK | 4138754 | c.1002C>G | synonymous_variant | 0.25 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
rifampicin | ||||||
isoniazid | ||||||
glpK | 4138757 | c.999A>G | synonymous_variant | 0.25 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
rifampicin | ||||||
isoniazid | ||||||
glpK | 4138763 | c.993G>A | synonymous_variant | 0.26 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
rifampicin | ||||||
isoniazid | ||||||
glpK | 4138775 | c.981C>A | synonymous_variant | 0.26 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
rifampicin | ||||||
isoniazid | ||||||
glpK | 4138781 | c.975G>C | synonymous_variant | 0.27 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
rifampicin | ||||||
isoniazid | ||||||
glpK | 4138802 | c.954G>C | synonymous_variant | 0.24 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
rifampicin | ||||||
isoniazid | ||||||
glpK | 4138817 | c.939T>G | synonymous_variant | 0.14 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
rifampicin | ||||||
isoniazid | ||||||
glpK | 4138822 | p.Asn312Asp | missense_variant | 0.14 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
rifampicin | ||||||
isoniazid | ||||||
glpK | 4138823 | c.933G>C | synonymous_variant | 0.13 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
rifampicin | ||||||
isoniazid | ||||||
embC | 4239298 | c.-565C>T | upstream_gene_variant | 0.19 | ethambutol | Not assoc w R |
embC | 4242643 | c.2781C>T | synonymous_variant | 1.0 | ethambutol | Not assoc w R |
embC | 4242803 | p.Val981Leu | missense_variant | 0.17 | ethambutol | Not assoc w R |
embA | 4243460 | c.228C>T | synonymous_variant | 0.91 | ethambutol | Not assoc w R |
embB | 4247491 | c.978G>C | synonymous_variant | 0.19 | ethambutol | |
embB | 4247497 | c.984T>C | synonymous_variant | 0.21 | ethambutol | |
embB | 4247506 | c.993C>G | synonymous_variant | 0.2 | ethambutol | |
embB | 4247512 | c.999T>C | synonymous_variant | 0.17 | ethambutol | |
embB | 4247536 | c.1023C>A | synonymous_variant | 0.15 | ethambutol | |
embB | 4247539 | c.1026T>C | synonymous_variant | 0.15 | ethambutol | |
embB | 4247550 | p.Ala346Gly | missense_variant | 0.15 | ethambutol | |
embB | 4247554 | c.1041T>C | synonymous_variant | 0.14 | ethambutol | |
embB | 4247566 | c.1053C>G | synonymous_variant | 0.15 | ethambutol | |
embB | 4247567 | c.1054C>T | synonymous_variant | 0.14 | ethambutol | |
embB | 4247572 | c.1059A>C | synonymous_variant | 0.17 | ethambutol | |
embB | 4247579 | p.Ala356Ile | missense_variant | 0.17 | ethambutol | |
embB | 4247590 | c.1077A>G | synonymous_variant | 0.15 | ethambutol | Not assoc w R - Interim |
aftB | 4267647 | p.Asp397Gly | missense_variant | 0.86 | ethambutol | Not assoc w R |
whiB6 | 4338595 | c.-75delG | upstream_gene_variant | 1.0 | capreomycin | Not assoc w R |
amikacin | Not assoc w R | |||||
kanamycin | Not assoc w R | |||||
whiB6 | 4338635 | c.-114A>C | upstream_gene_variant | 0.23 | capreomycin | Uncertain significance |
amikacin | Uncertain significance | |||||
kanamycin | Uncertain significance | |||||
whiB6 | 4338732 | c.-211C>T | upstream_gene_variant | 1.0 | capreomycin | |
amikacin | ||||||
kanamycin | ||||||
gid | 4407588 | c.615A>G | synonymous_variant | 0.9 | streptomycin | Not assoc w R |
gid | 4407927 | p.Glu92Asp | missense_variant | 0.89 | streptomycin | Not assoc w R |