TB-Profiler result

Run: ERR11465025
Summary

Run ID: ERR11465025

Sample name:

Date: 2024-03-26T22:08:16.866145

Number of reads: 1138597

Percentage reads mapped: 93.41

Median coverage: 34.0

Strain: lineage4.1.1.3

Spoligotype:

Drug-resistance: Other

Download CSV Download TXT Download JSON
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage4.1 Euro-American None 1.0
lineage4.1.1.3 Euro-American (X-type) RD193 1.0
lineage4 Euro-American None 1.0
lineage4.1.1 Euro-American (X-type) None 1.0
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol embB p.His312Arg Mutation from literature
pyrazinamide
streptomycin rrs n.462C>T Uncertain significance Mutation from literature
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
rrs 1472307 n.462C>T non_coding_transcript_exon_variant 0.38 streptomycin Uncertain significance Mutation from literature
embB 4247448 p.His312Arg missense_variant 0.26 ethambutol Mutation from literature
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
gyrB 4982 c.-258C>G upstream_gene_variant 1.0 levofloxacin
moxifloxacin
gyrA 6703 c.-599G>C upstream_gene_variant 0.24 levofloxacin
moxifloxacin
gyrA 6709 c.-593A>G upstream_gene_variant 0.27 levofloxacin
moxifloxacin
gyrA 6712 c.-590G>C upstream_gene_variant 0.24 levofloxacin
moxifloxacin
gyrB 6728 c.1489_1491delCTAinsTG frameshift_variant&stop_gained 0.27 levofloxacin Uncertain significance
moxifloxacin
gyrA 6742 c.-560A>G upstream_gene_variant 0.26 levofloxacin
moxifloxacin
gyrB 6745 c.1506T>G synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6751 c.-551G>C upstream_gene_variant 0.26 levofloxacin
moxifloxacin
gyrA 6760 c.-542G>C upstream_gene_variant 0.25 levofloxacin
moxifloxacin
gyrB 6763 c.1524G>C synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6973 c.-329G>C upstream_gene_variant 0.17 levofloxacin
moxifloxacin
gyrA 6982 c.-320A>C upstream_gene_variant 0.18 levofloxacin
moxifloxacin
gyrA 7006 c.-296T>C upstream_gene_variant 0.18 levofloxacin
moxifloxacin
gyrA 7007 c.-295C>T upstream_gene_variant 0.18 levofloxacin
moxifloxacin
gyrA 7010 c.-292C>T upstream_gene_variant 0.18 levofloxacin
moxifloxacin
gyrA 7015 c.-287G>A upstream_gene_variant 0.18 levofloxacin
moxifloxacin
gyrA 7018 c.-284G>A upstream_gene_variant 0.18 levofloxacin
moxifloxacin
gyrB 7023 p.Leu595Gln missense_variant 0.15 levofloxacin
moxifloxacin
gyrA 7033 c.-269G>C upstream_gene_variant 0.17 levofloxacin
moxifloxacin
gyrB 7051 p.Glu604Asp missense_variant 0.16 levofloxacin
moxifloxacin
gyrA 7066 c.-236G>C upstream_gene_variant 0.15 levofloxacin
moxifloxacin
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 8294 c.993T>C synonymous_variant 0.14 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8324 c.1023T>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8330 c.1029C>G synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8339 c.1038A>G synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8340 p.Ala347Ser missense_variant 0.18 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8576 c.1275C>G synonymous_variant 0.13 levofloxacin
moxifloxacin
gyrA 8588 c.1287G>A synonymous_variant 0.14 levofloxacin
moxifloxacin
gyrA 8597 c.1296C>G synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8603 c.1302A>G synonymous_variant 0.14 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8619 c.1318_1320delTTGinsCA frameshift_variant&missense_variant 0.16 levofloxacin
moxifloxacin
gyrA 8624 c.1323G>C synonymous_variant 0.14 levofloxacin
moxifloxacin
gyrA 8636 c.1335A>C synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8642 c.1341A>G synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8672 c.1371A>G synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9056 c.1755C>G synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9062 c.1761C>G synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 9068 c.1767G>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 9071 c.1770G>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 9080 c.1779G>T synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 9089 c.1788G>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 9099 c.1798_1800delTTAinsCG frameshift_variant&missense_variant 0.18 levofloxacin
moxifloxacin
gyrA 9104 c.1803C>G synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9119 c.1818A>G synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 9122 c.1821C>G synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9143 c.1842T>C synonymous_variant 0.34 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9152 c.1851C>T synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9153 p.Thr618Glu missense_variant 0.26 levofloxacin
moxifloxacin
gyrA 9158 c.1857C>T synonymous_variant 0.29 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9161 c.1860C>G synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 9182 c.1881T>C synonymous_variant 0.28 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9191 c.1890G>C synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 9200 c.1899A>G synonymous_variant 0.28 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9204 p.Ser635Thr missense_variant 0.29 levofloxacin
moxifloxacin
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
mshA 575566 c.219G>A synonymous_variant 1.0 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
Rv0565c 657269 p.Ser68Pro missense_variant 1.0 ethionamide Uncertain significance
hadA 731682 c.-248C>G upstream_gene_variant 0.17 isoniazid
hadA 731687 c.-243_-242insCACAGATCTTTT upstream_gene_variant 0.17 isoniazid
hadA 731693 c.-237C>A upstream_gene_variant 0.17 isoniazid
hadA 731696 c.-233_-232delTT upstream_gene_variant 0.18 isoniazid
hadA 731708 c.-222G>C upstream_gene_variant 0.22 isoniazid
hadA 731710 c.-220A>T upstream_gene_variant 0.23 isoniazid
hadA 731711 c.-219T>C upstream_gene_variant 0.23 isoniazid
hadA 731717 c.-213T>G upstream_gene_variant 0.23 isoniazid
hadA 731732 c.-198G>A upstream_gene_variant 0.24 isoniazid
hadA 731747 c.-183T>C upstream_gene_variant 0.26 isoniazid
hadA 731774 c.-156T>C upstream_gene_variant 0.17 isoniazid
rpoB 760091 c.285G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760101 c.295T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760112 c.306T>C synonymous_variant 0.19 rifampicin
rpoB 760118 c.312T>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760121 c.315T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760130 p.Asp108Glu missense_variant 0.22 rifampicin Uncertain significance
rpoB 760139 c.333A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760142 c.336C>G synonymous_variant 0.2 rifampicin
rpoB 760283 c.477G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760298 c.492G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 760307 c.501T>C synonymous_variant 0.2 rifampicin
rpoB 760310 c.504G>C synonymous_variant 0.19 rifampicin
rpoB 760328 c.522G>C synonymous_variant 0.2 rifampicin
rpoB 760331 c.525G>C synonymous_variant 0.2 rifampicin
rpoB 760340 c.534G>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760361 c.555T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760370 c.564C>G synonymous_variant 0.26 rifampicin
rpoB 760376 p.Asp190Glu missense_variant 0.26 rifampicin Uncertain significance
rpoB 760380 p.Thr192Leu missense_variant 0.23 rifampicin
rpoB 760406 c.600G>C synonymous_variant 0.22 rifampicin
rpoB 760412 c.606C>G synonymous_variant 0.22 rifampicin
rpoB 760424 c.618C>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760430 c.624T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760475 c.669A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760481 c.675G>T synonymous_variant 0.18 rifampicin
rpoB 760484 c.678A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760591 p.Val262Ala missense_variant 0.18 rifampicin
rpoB 760611 c.805T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 760670 c.864G>C synonymous_variant 0.15 rifampicin
rpoB 760715 c.909C>G synonymous_variant 0.16 rifampicin
rpoB 760718 c.912C>T synonymous_variant 0.16 rifampicin
rpoB 760925 c.1119T>C synonymous_variant 0.24 rifampicin
rpoB 760928 c.1122G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760931 c.1125C>G synonymous_variant 0.24 rifampicin
rpoB 760934 c.1128C>T synonymous_variant 0.24 rifampicin
rpoB 760946 c.1140A>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 760982 c.1176G>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 760985 c.1179G>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 760991 c.1185G>C synonymous_variant 0.34 rifampicin
rpoB 761006 c.1200C>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 761015 c.1209G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 761021 c.1215G>C synonymous_variant 0.27 rifampicin
rpoB 761027 c.1221A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 761036 c.1230G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 761037 c.1231T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 761057 c.1251G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 761408 c.1602G>C synonymous_variant 0.3 rifampicin
rpoB 761414 c.1608A>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 761423 c.1617T>C synonymous_variant 0.3 rifampicin
rpoB 761435 c.1629T>C synonymous_variant 0.29 rifampicin
rpoB 761438 c.1632G>C synonymous_variant 0.29 rifampicin
rpoB 761439 c.1633_1635delGACinsAG frameshift_variant&missense_variant 0.29 rifampicin
rpoB 761444 c.1638T>C synonymous_variant 0.28 rifampicin
rpoB 761447 c.1641C>G synonymous_variant 0.28 rifampicin
rpoB 761452 p.Val549Glu missense_variant 0.28 rifampicin
rpoB 761457 p.Pro551Ser missense_variant 0.26 rifampicin
rpoB 761477 c.1671C>G synonymous_variant 0.28 rifampicin
rpoB 761492 c.1686G>C synonymous_variant 0.28 rifampicin
rpoB 761615 c.1809A>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 761645 c.1839C>G synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 761648 c.1842T>C synonymous_variant 0.14 rifampicin
rpoB 761657 c.1851C>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 761675 c.1869G>C synonymous_variant 0.23 rifampicin
rpoB 761747 c.1941G>C synonymous_variant 0.24 rifampicin
rpoB 761750 c.1944G>C synonymous_variant 0.25 rifampicin
rpoB 761765 c.1959T>C synonymous_variant 0.27 rifampicin
rpoB 761772 p.His656Ala missense_variant 0.27 rifampicin
rpoB 761778 p.Asn658Asp missense_variant 0.27 rifampicin
rpoB 761791 p.Arg662His missense_variant 0.25 rifampicin
rpoB 761885 c.2079T>C synonymous_variant 0.21 rifampicin
rpoB 761906 c.2100C>G synonymous_variant 0.16 rifampicin
rpoB 761909 c.2103T>C synonymous_variant 0.16 rifampicin
rpoB 761912 c.2106T>C synonymous_variant 0.17 rifampicin
rpoB 761915 p.Asp703Glu missense_variant 0.16 rifampicin
rpoB 761916 p.Asp704Asn missense_variant 0.16 rifampicin
rpoB 761948 c.2142G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 761954 c.2148C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 762008 c.2202C>T synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 762014 c.2208C>T synonymous_variant 0.31 rifampicin
rpoB 762017 c.2211A>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 762053 c.2247T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 762062 c.2256T>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 762083 c.2277T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 762086 c.2280G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 762101 c.2295C>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 762114 p.Ile770Val missense_variant 0.27 rifampicin Uncertain significance
rpoB 762176 c.2370T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 762185 c.2379G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 762206 c.2400C>G synonymous_variant 0.38 rifampicin
rpoB 762233 c.2427G>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 762246 c.2440C>T synonymous_variant 0.33 rifampicin
rpoB 762254 c.2448T>G synonymous_variant 0.33 rifampicin
rpoB 762257 c.2451C>G synonymous_variant 0.33 rifampicin
rpoB 762266 c.2460T>C synonymous_variant 0.27 rifampicin
rpoB 762284 c.2478G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 762293 c.2487T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 762314 c.2508C>T synonymous_variant 0.22 rifampicin
rpoB 762317 c.2511A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 762329 c.2523G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 762338 c.2532T>C synonymous_variant 0.2 rifampicin
rpoB 762347 c.2541T>C synonymous_variant 0.24 rifampicin
rpoB 762359 c.2553C>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 762362 p.Glu852Asp missense_variant 0.2 rifampicin
rpoB 762369 c.2563T>C synonymous_variant 0.22 rifampicin
rpoC 762398 c.-972T>C upstream_gene_variant 0.26 rifampicin
rpoC 762401 c.-969G>C upstream_gene_variant 0.27 rifampicin
rpoB 762404 c.2598T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 762410 c.-960T>C upstream_gene_variant 0.31 rifampicin
rpoB 762416 c.2610A>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 762419 c.-951C>G upstream_gene_variant 0.32 rifampicin
rpoC 762434 c.-936T>C upstream_gene_variant 0.35 rifampicin
rpoB 762449 c.2643C>A synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 762467 c.-903C>T upstream_gene_variant 0.36 rifampicin
rpoC 763570 c.201G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 763573 c.204G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 763594 c.225C>T synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 763603 c.234C>T synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 763636 c.267T>C synonymous_variant 0.27 rifampicin
rpoC 763657 c.288G>A synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 763660 c.291T>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 763675 c.306C>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 763696 c.327T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 763702 c.333C>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 763717 c.348T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 763723 c.354G>C synonymous_variant 0.26 rifampicin
rpoC 763732 c.363C>G synonymous_variant 0.28 rifampicin
rpoC 763741 c.372C>T synonymous_variant 0.28 rifampicin
rpoC 763744 c.375G>C synonymous_variant 0.27 rifampicin
rpoC 763765 c.396T>C synonymous_variant 0.39 rifampicin
rpoC 763774 c.405G>C synonymous_variant 0.39 rifampicin
rpoC 763807 c.438T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 763816 c.447C>G synonymous_variant 0.33 rifampicin
rpoC 763835 p.Ala156Met missense_variant 0.26 rifampicin
rpoC 763853 p.Val162Ile missense_variant 0.28 rifampicin
rpoC 763858 c.489A>G synonymous_variant 0.29 rifampicin
rpoC 763872 p.Gly168Ala missense_variant 0.26 rifampicin
rpoC 763876 p.Glu169Asp missense_variant 0.27 rifampicin
rpoC 763879 c.510A>G synonymous_variant 0.27 rifampicin
rpoC 763888 c.519G>C synonymous_variant 0.2 rifampicin
rpoC 763891 c.522G>C synonymous_variant 0.2 rifampicin
rpoC 763894 c.525A>G synonymous_variant 0.21 rifampicin
rpoC 763900 c.531G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764024 c.655_657delTTGinsCC frameshift_variant&missense_variant 0.32 rifampicin
rpoC 764032 p.Asp221Glu missense_variant 0.33 rifampicin
rpoC 764040 p.Ser224Thr missense_variant 0.31 rifampicin
rpoC 764044 c.675T>C synonymous_variant 0.31 rifampicin
rpoC 764059 c.690G>T synonymous_variant 0.31 rifampicin
rpoC 764083 c.714A>G synonymous_variant 0.3 rifampicin
rpoC 764098 c.729A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 764101 c.732C>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764102 p.Val245Ile missense_variant 0.29 rifampicin
rpoC 764112 p.Tyr248Phe missense_variant 0.38 rifampicin
rpoC 764116 c.747C>T synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 764131 c.762T>C synonymous_variant 0.28 rifampicin
rpoC 764188 c.819A>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 764195 p.Ser276Ile missense_variant 0.34 rifampicin
rpoC 764203 c.834G>C synonymous_variant 0.35 rifampicin
rpoC 764206 c.837T>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 764215 c.846A>G synonymous_variant 0.4 rifampicin
rpoC 764236 c.867G>A synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 764248 c.879C>G synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 764257 c.888G>C synonymous_variant 0.35 rifampicin
rpoC 764266 c.897T>C synonymous_variant 0.34 rifampicin
rpoC 764269 c.900G>C synonymous_variant 0.37 rifampicin
rpoC 764272 c.903G>C synonymous_variant 0.36 rifampicin
rpoC 764278 c.909A>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 764353 c.984G>C synonymous_variant 0.3 rifampicin
rpoC 764428 c.1059G>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 764431 c.1062G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 764434 c.1065A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764446 c.1077T>C synonymous_variant 0.15 rifampicin
rpoC 764458 c.1089G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764461 c.1092A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764489 c.1120C>T synonymous_variant 0.2 rifampicin
rpoC 764497 c.1128A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764510 c.1141C>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 764521 c.1152T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764527 c.1158C>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 764536 c.1167G>C synonymous_variant 0.29 rifampicin
rpoC 764539 c.1170C>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 764548 c.1179G>A synonymous_variant 0.56 rifampicin
rpoC 764551 c.1182G>C synonymous_variant 0.53 rifampicin
rpoC 764554 c.1185C>T synonymous_variant 0.48 rifampicin
rpoC 764560 c.1191T>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 764566 c.1197C>G synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 764575 c.1206T>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 764593 c.1224C>T synonymous_variant 0.39 rifampicin
rpoC 764611 c.1242G>T synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>C synonymous_variant 0.23 rifampicin
rpoC 764651 c.1282_1284delTCGinsAGC synonymous_variant 0.24 rifampicin
rpoC 764815 c.1446A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 764827 c.1458G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764858 c.1489T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 764872 c.1503A>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764888 c.1519T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 764911 c.1542A>G synonymous_variant 0.3 rifampicin
rpoC 764932 c.1563C>A synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764948 c.1579T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 765150 p.Gly594Glu missense_variant 1.0 rifampicin Not assoc w R
rpoC 765700 c.2331T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 765734 c.2365T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 765739 c.2370G>T synonymous_variant 0.2 rifampicin
rpoC 765751 c.2382C>G synonymous_variant 0.2 rifampicin
rpoC 765753 p.Asp795Ala missense_variant 0.2 rifampicin Uncertain significance
rpoC 765772 c.2403C>G synonymous_variant 0.29 rifampicin
rpoC 765784 c.2415C>G synonymous_variant 0.28 rifampicin
rpoC 765787 c.2418C>T synonymous_variant 0.3 rifampicin
rpoC 765793 c.2424C>G synonymous_variant 0.28 rifampicin
rpoC 765796 c.2427C>T synonymous_variant 0.29 rifampicin
rpoC 765811 c.2442T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 765814 c.2445A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 766327 c.2958C>A synonymous_variant 0.15 rifampicin
rpoC 766345 c.2976T>C synonymous_variant 0.19 rifampicin
rpoC 766348 c.2979A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 766357 c.2988C>T synonymous_variant 0.2 rifampicin
rpoC 766363 c.2994G>C synonymous_variant 0.21 rifampicin
rpoC 766366 c.2997C>G synonymous_variant 0.21 rifampicin
rpoC 766381 c.3012C>T synonymous_variant 0.26 rifampicin
rpoC 766384 c.3015A>G synonymous_variant 0.28 rifampicin
rpoC 766390 c.3021C>T synonymous_variant 0.25 rifampicin
rpoC 766393 c.3024C>G synonymous_variant 0.25 rifampicin
rpoC 766522 c.3153C>G synonymous_variant 0.14 rifampicin
rpoC 766531 c.3162G>C synonymous_variant 0.15 rifampicin
rpoC 766594 c.3225G>C synonymous_variant 0.18 rifampicin
rpoC 766597 c.3228C>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 766607 p.Ile1080Leu missense_variant 0.22 rifampicin
rpoC 766630 c.3261G>C synonymous_variant 0.23 rifampicin
rpoC 766657 c.3288A>G synonymous_variant 0.22 rifampicin
rpoC 766672 c.3303T>C synonymous_variant 0.18 rifampicin
rpoC 766673 p.Gly1102Asn missense_variant 0.18 rifampicin
rpoC 766726 c.3357T>C synonymous_variant 0.21 rifampicin
rpoC 766738 c.3369G>C synonymous_variant 0.24 rifampicin
rpoC 766765 c.3396A>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 766774 c.3405T>C synonymous_variant 0.28 rifampicin
rpoC 766801 c.3432C>G synonymous_variant 0.26 rifampicin
rpoC 766804 c.3435A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 766861 c.3492G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 766864 c.3495G>C synonymous_variant 0.25 rifampicin
rpoC 766933 c.3564A>G synonymous_variant 0.29 rifampicin
rpoC 766945 c.3576A>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 766963 c.3594T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 766972 c.3603G>C synonymous_variant 0.32 rifampicin
rpoC 766996 c.3627C>T synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 767059 c.3690T>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 767062 c.3693C>A synonymous_variant 0.19 rifampicin
mmpL5 775639 p.Ile948Val missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781655 c.96T>C synonymous_variant 0.28 streptomycin
rpsL 781736 c.177T>C synonymous_variant 0.29 streptomycin
rpsL 781742 c.183C>T synonymous_variant 0.25 streptomycin
rpsL 781754 c.195G>C synonymous_variant 0.31 streptomycin
rpsL 781760 c.201T>C synonymous_variant 0.29 streptomycin
rpsL 781772 c.213C>A synonymous_variant 0.31 streptomycin
rpsL 781808 c.249C>T synonymous_variant 0.29 streptomycin
rpsL 781811 c.252C>T synonymous_variant 0.29 streptomycin
rpsL 781832 c.273T>C synonymous_variant 0.26 streptomycin
rpsL 781838 c.279G>C synonymous_variant 0.28 streptomycin
rpsL 781841 c.282C>G synonymous_variant 0.27 streptomycin
rpsL 781865 c.306G>C synonymous_variant 0.26 streptomycin
rpsL 781868 c.309T>C synonymous_variant 0.25 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.25 streptomycin
rpsL 781877 c.318T>C synonymous_variant 0.27 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.23 streptomycin
rpsL 781898 c.339A>T synonymous_variant 0.23 streptomycin
rpsL 781916 c.357T>C synonymous_variant 0.28 streptomycin
rpsL 781929 p.Gly124Ser missense_variant 0.24 streptomycin Uncertain significance
rplC 800219 c.-590T>C upstream_gene_variant 1.0 linezolid
rplC 800516 c.-293G>T upstream_gene_variant 0.25 linezolid
rplC 800537 c.-272C>T upstream_gene_variant 0.31 linezolid
rplC 800540 c.-269T>C upstream_gene_variant 0.3 linezolid
rplC 800546 c.-263T>G upstream_gene_variant 0.32 linezolid
rplC 800567 c.-242A>G upstream_gene_variant 0.33 linezolid
rplC 800582 c.-227C>G upstream_gene_variant 0.35 linezolid
rplC 800612 c.-197A>G upstream_gene_variant 0.37 linezolid
rplC 800618 c.-191T>C upstream_gene_variant 0.4 linezolid
rplC 800627 c.-182C>T upstream_gene_variant 0.4 linezolid
rplC 800648 c.-161A>T upstream_gene_variant 0.32 linezolid
rplC 800654 c.-155T>C upstream_gene_variant 0.33 linezolid
rplC 800693 c.-116A>G upstream_gene_variant 0.25 linezolid
rplC 800703 c.-106T>C upstream_gene_variant 0.25 linezolid
rplC 800715 c.-94A>C upstream_gene_variant 0.23 linezolid
rplC 800720 c.-89T>C upstream_gene_variant 0.24 linezolid
rplC 800723 c.-86C>G upstream_gene_variant 0.24 linezolid
rplC 800747 c.-62C>G upstream_gene_variant 0.24 linezolid
rplC 800771 c.-38C>T upstream_gene_variant 0.25 linezolid
rplC 800794 c.-15A>G upstream_gene_variant 0.23 linezolid
rplC 800796 c.-13A>G upstream_gene_variant 0.23 linezolid
rplC 800798 c.-10_-9delGG upstream_gene_variant 0.23 linezolid
rplC 800814 c.6A>G synonymous_variant 0.22 linezolid
rplC 800817 c.9A>T synonymous_variant 0.19 linezolid
rplC 801339 c.531T>C synonymous_variant 0.17 linezolid
rplC 801341 p.Leu178Gln missense_variant 0.17 linezolid
rplC 801348 c.540T>G synonymous_variant 0.18 linezolid
rplC 801357 c.549T>C synonymous_variant 0.17 linezolid
rplC 801367 p.Ala187Thr missense_variant 0.17 linezolid
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471969 n.124T>C non_coding_transcript_exon_variant 0.36 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471970 n.125G>A non_coding_transcript_exon_variant 0.39 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472028 n.183A>T non_coding_transcript_exon_variant 0.18 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472029 n.184C>T non_coding_transcript_exon_variant 0.21 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472030 n.185G>T non_coding_transcript_exon_variant 0.21 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472031 n.186G>A non_coding_transcript_exon_variant 0.2 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472033 n.188A>G non_coding_transcript_exon_variant 0.19 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472034 n.189T>C non_coding_transcript_exon_variant 0.19 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472044 n.199G>T non_coding_transcript_exon_variant 0.22 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472045 n.200T>A non_coding_transcript_exon_variant 0.21 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472053 n.211_212delGC non_coding_transcript_exon_variant 0.21 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472061 n.216A>T non_coding_transcript_exon_variant 0.21 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472075 n.230A>G non_coding_transcript_exon_variant 0.24 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.26 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473105 n.1260G>A non_coding_transcript_exon_variant 0.33 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473123 n.1278delAinsTT non_coding_transcript_exon_variant 0.31 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.37 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473290 n.1445C>T non_coding_transcript_exon_variant 0.29 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrl 1473668 n.11C>T non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid
rrl 1473756 n.99G>A non_coding_transcript_exon_variant 0.53 capreomycin
linezolid
rrl 1473758 n.101G>T non_coding_transcript_exon_variant 0.54 capreomycin Uncertain significance
linezolid
rrl 1473806 n.149C>T non_coding_transcript_exon_variant 0.53 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473877 n.220G>A non_coding_transcript_exon_variant 0.58 capreomycin
linezolid
rrl 1473898 n.241C>T non_coding_transcript_exon_variant 0.55 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473943 n.286G>T non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid
rrl 1473945 n.288T>A non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid
rrl 1473946 n.289A>T non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid
rrl 1473986 n.329T>C non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1473987 n.330G>A non_coding_transcript_exon_variant 0.35 capreomycin
linezolid
rrl 1473995 n.338G>T non_coding_transcript_exon_variant 0.5 capreomycin
linezolid
rrl 1474001 n.344C>T non_coding_transcript_exon_variant 0.52 capreomycin Not assoc w R
linezolid Not assoc w R
rrl 1474009 n.352A>G non_coding_transcript_exon_variant 0.55 capreomycin
linezolid
rrl 1474012 n.355C>T non_coding_transcript_exon_variant 0.47 capreomycin
linezolid
rrl 1474093 n.436G>T non_coding_transcript_exon_variant 0.46 capreomycin
linezolid
rrl 1474099 n.442G>A non_coding_transcript_exon_variant 0.4 capreomycin
linezolid
rrl 1474103 n.446A>T non_coding_transcript_exon_variant 0.38 capreomycin
linezolid
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474181 n.524C>T non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid
rrl 1474356 n.699T>C non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid
rrl 1474362 n.705A>G non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474376 n.719T>C non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1474639 n.982G>A non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474823 n.1166C>T non_coding_transcript_exon_variant 0.42 capreomycin
linezolid
rrl 1474831 n.1174A>G non_coding_transcript_exon_variant 0.45 capreomycin Uncertain significance
linezolid
rrl 1475199 n.1542G>A non_coding_transcript_exon_variant 0.54 capreomycin
linezolid
rrl 1475206 n.1549C>T non_coding_transcript_exon_variant 0.59 capreomycin Uncertain significance
linezolid
rrl 1475209 n.1552G>C non_coding_transcript_exon_variant 0.58 capreomycin Uncertain significance
linezolid
rrl 1475213 n.1556C>T non_coding_transcript_exon_variant 0.6 capreomycin Uncertain significance
linezolid
rrl 1475249 n.1592T>C non_coding_transcript_exon_variant 0.48 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475252 n.1595C>T non_coding_transcript_exon_variant 0.44 capreomycin
linezolid
rrl 1475266 n.1609T>C non_coding_transcript_exon_variant 0.48 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475267 n.1610G>A non_coding_transcript_exon_variant 0.48 capreomycin
linezolid
rrl 1475275 n.1618C>T non_coding_transcript_exon_variant 0.41 capreomycin
linezolid
rrl 1475276 n.1619T>C non_coding_transcript_exon_variant 0.41 capreomycin
linezolid
rrl 1475291 n.1634A>C non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475355 n.1698C>T non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475369 n.1712G>T non_coding_transcript_exon_variant 0.38 capreomycin
linezolid
rrl 1475402 n.1745C>T non_coding_transcript_exon_variant 0.42 capreomycin
linezolid
rrl 1475419 n.1762C>T non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid
rrl 1475429 n.1772G>A non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475436 n.1779C>T non_coding_transcript_exon_variant 0.41 capreomycin
linezolid
rrl 1475483 n.1826C>T non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475505 n.1848G>A non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475599 n.1942A>G non_coding_transcript_exon_variant 0.57 capreomycin
linezolid Uncertain significance
rrl 1475608 n.1951T>C non_coding_transcript_exon_variant 0.54 capreomycin Uncertain significance
linezolid
rrl 1475642 n.1985T>C non_coding_transcript_exon_variant 0.42 capreomycin
linezolid
rrl 1475657 n.2000A>G non_coding_transcript_exon_variant 0.41 capreomycin
linezolid
rrl 1475659 n.2002G>T non_coding_transcript_exon_variant 0.41 capreomycin
linezolid
rrl 1475761 n.2104_2106delCGCinsGT non_coding_transcript_exon_variant 0.46 capreomycin
linezolid
rrl 1475765 n.2111delG non_coding_transcript_exon_variant 0.5 capreomycin
linezolid
rrl 1475881 n.2224T>C non_coding_transcript_exon_variant 0.55 capreomycin
linezolid
rrl 1476214 n.2557G>A non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.43 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.26 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476594 n.2937C>T non_coding_transcript_exon_variant 0.26 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476597 n.2940G>A non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid
rrl 1476603 n.2946G>A non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476608 n.2951C>G non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476689 n.3032A>T non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1476690 n.3033C>T non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid
rrl 1476693 n.3036G>A non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1476695 n.3038T>A non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1476716 n.3059A>C non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid
rrl 1476726 n.3069A>G non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
inhA 1674582 c.381T>C synonymous_variant 0.17 ethionamide
isoniazid
inhA 1674585 c.384T>C synonymous_variant 0.17 ethionamide
isoniazid
inhA 1674589 p.Met130Leu missense_variant 0.17 ethionamide
isoniazid
inhA 1674601 p.Leu134Thr missense_variant 0.19 ethionamide
isoniazid
inhA 1674624 c.423A>C synonymous_variant 0.22 ethionamide
isoniazid
inhA 1674630 c.429C>G synonymous_variant 0.2 ethionamide
isoniazid
inhA 1674672 c.471C>G synonymous_variant 0.24 ethionamide
isoniazid
inhA 1674703 c.502T>C synonymous_variant 0.2 ethionamide
isoniazid
inhA 1674708 c.507G>A synonymous_variant 0.17 ethionamide
isoniazid
inhA 1674718 c.517A>C synonymous_variant 0.2 ethionamide
isoniazid
inhA 1674723 c.522C>T synonymous_variant 0.18 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
rpsA 1833532 c.-10A>C upstream_gene_variant 0.14 pyrazinamide
rpsA 1833554 p.Thr5Ala missense_variant 0.18 pyrazinamide Uncertain significance
rpsA 1833568 c.27G>C synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
rpsA 1833589 c.48A>T synonymous_variant 0.19 pyrazinamide
rpsA 1833595 c.54T>C synonymous_variant 0.19 pyrazinamide
rpsA 1833661 c.120A>G synonymous_variant 0.31 pyrazinamide
rpsA 1833667 c.126C>G synonymous_variant 0.34 pyrazinamide
rpsA 1833721 c.180A>G synonymous_variant 0.29 pyrazinamide
rpsA 1833724 c.183C>G synonymous_variant 0.29 pyrazinamide
rpsA 1833727 c.186G>C synonymous_variant 0.26 pyrazinamide
rpsA 1833742 c.201A>G synonymous_variant 0.27 pyrazinamide
rpsA 1833745 c.204G>C synonymous_variant 0.28 pyrazinamide
rpsA 1833748 c.207C>G synonymous_variant 0.28 pyrazinamide
rpsA 1833874 c.333T>C synonymous_variant 0.34 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.38 pyrazinamide
rpsA 1833940 c.399C>G synonymous_variant 0.31 pyrazinamide
rpsA 1833971 c.430C>T synonymous_variant 0.26 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.24 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.26 pyrazinamide
rpsA 1834021 c.480C>T synonymous_variant 0.24 pyrazinamide
rpsA 1834540 c.999G>C synonymous_variant 0.17 pyrazinamide
rpsA 1834546 c.1005T>C synonymous_variant 0.17 pyrazinamide
rpsA 1834609 c.1068T>C synonymous_variant 0.21 pyrazinamide
rpsA 1834633 c.1092A>G synonymous_variant 0.24 pyrazinamide
rpsA 1834639 c.1098T>C synonymous_variant 0.23 pyrazinamide
rpsA 1834654 p.Glu371Asp missense_variant 0.31 pyrazinamide
rpsA 1834732 c.1191T>C synonymous_variant 0.27 pyrazinamide
rpsA 1834733 p.Ala398Ser missense_variant 0.27 pyrazinamide
rpsA 1834738 c.1197A>G synonymous_variant 0.26 pyrazinamide
rpsA 1834753 c.1212T>C synonymous_variant 0.25 pyrazinamide
rpsA 1834775 p.Ala412Thr missense_variant 0.22 pyrazinamide
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
kasA 2517950 c.-165C>G upstream_gene_variant 0.34 isoniazid
eis 2715620 c.-288C>T upstream_gene_variant 1.0 amikacin
kanamycin
Rv2477c 2783656 c.387G>C synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783665 c.378A>G synonymous_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783674 c.369T>C synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783883 c.160T>C synonymous_variant 0.32 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783884 c.159T>C synonymous_variant 0.32 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783887 c.156C>G synonymous_variant 0.33 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783914 c.129T>C synonymous_variant 0.39 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
mtrB 3625065 p.Met517Leu missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
mtrB 3625636 c.978C>G synonymous_variant 0.26 bedaquiline
rifampicin Not assoc w R - Interim
fbiB 3641298 c.-237G>A upstream_gene_variant 1.0 clofazimine
pretomanid
delamanid
rpoA 3877571 p.Pro313Ala missense_variant 0.16 rifampicin
rpoA 3877587 c.921A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3877613 p.Ile299Val missense_variant 0.35 rifampicin
rpoA 3877656 c.852T>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoA 3877668 c.840A>G synonymous_variant 0.31 rifampicin
rpoA 3877679 p.Ala277Ser missense_variant 0.3 rifampicin
rpoA 3877686 c.822A>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoA 3877692 c.816G>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoA 3877704 c.804G>C synonymous_variant 0.29 rifampicin
rpoA 3877737 c.771G>C synonymous_variant 0.26 rifampicin
rpoA 3877743 c.765T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoA 3878761 c.-254G>C upstream_gene_variant 0.25 rifampicin
rpoA 3878764 c.-257A>G upstream_gene_variant 0.26 rifampicin
rpoA 3878785 c.-278T>G upstream_gene_variant 0.28 rifampicin
rpoA 3878788 c.-281G>C upstream_gene_variant 0.28 rifampicin Uncertain significance
rpoA 3878806 c.-299C>G upstream_gene_variant 0.24 rifampicin
rpoA 3878809 c.-302T>C upstream_gene_variant 0.24 rifampicin
rpoA 3878824 c.-317G>C upstream_gene_variant 0.27 rifampicin
rpoA 3878833 c.-326C>G upstream_gene_variant 0.24 rifampicin
rpoA 3878836 c.-331_-329delAAGinsTCC upstream_gene_variant 0.2 rifampicin
rpoA 3878853 c.-346G>A upstream_gene_variant 0.26 rifampicin
rpoA 3878878 c.-371T>C upstream_gene_variant 0.21 rifampicin Uncertain significance
rpoA 3878909 c.-402A>G upstream_gene_variant 0.2 rifampicin
rpoA 3878914 c.-407T>C upstream_gene_variant 0.17 rifampicin Uncertain significance
rpoA 3878917 c.-410G>A upstream_gene_variant 0.16 rifampicin Uncertain significance
rpoA 3878938 c.-431T>C upstream_gene_variant 0.14 rifampicin
rpoA 3878947 c.-440G>C upstream_gene_variant 0.15 rifampicin Uncertain significance
rpoA 3878968 c.-461T>C upstream_gene_variant 0.18 rifampicin Uncertain significance
rpoA 3878976 c.-469A>G upstream_gene_variant 0.18 rifampicin Uncertain significance
rpoA 3878986 c.-479G>C upstream_gene_variant 0.18 rifampicin
rpoA 3878998 c.-491C>G upstream_gene_variant 0.21 rifampicin Uncertain significance
rpoA 3879005 c.-499_-498delAAinsCG upstream_gene_variant 0.18 rifampicin
rpoA 3879013 c.-506A>G upstream_gene_variant 0.19 rifampicin
clpC1 4038356 c.2349T>C synonymous_variant 0.15 pyrazinamide
clpC1 4038359 c.2346A>G synonymous_variant 0.16 pyrazinamide
clpC1 4038368 c.2337T>C synonymous_variant 0.22 pyrazinamide
clpC1 4038392 c.2313C>T synonymous_variant 0.14 pyrazinamide
clpC1 4038683 c.2022T>C synonymous_variant 0.15 pyrazinamide Not assoc w R - Interim
clpC1 4038695 c.2010C>G synonymous_variant 0.2 pyrazinamide
clpC1 4038701 c.2004G>C synonymous_variant 0.2 pyrazinamide
clpC1 4038704 c.2001T>C synonymous_variant 0.18 pyrazinamide
clpC1 4038707 c.1998C>G synonymous_variant 0.18 pyrazinamide
clpC1 4038710 c.1995G>C synonymous_variant 0.18 pyrazinamide
clpC1 4038713 c.1992T>C synonymous_variant 0.17 pyrazinamide
clpC1 4038749 c.1956C>G synonymous_variant 0.18 pyrazinamide
clpC1 4038755 c.1950G>T synonymous_variant 0.19 pyrazinamide
clpC1 4038770 c.1935C>T synonymous_variant 0.17 pyrazinamide
clpC1 4038773 c.1932T>C synonymous_variant 0.17 pyrazinamide
clpC1 4038782 c.1923G>C synonymous_variant 0.18 pyrazinamide
clpC1 4038812 c.1893T>C synonymous_variant 0.14 pyrazinamide
clpC1 4038860 c.1845G>C synonymous_variant 0.23 pyrazinamide Not assoc w R - Interim
clpC1 4038878 c.1827A>G synonymous_variant 0.24 pyrazinamide Not assoc w R - Interim
clpC1 4038908 c.1797C>G synonymous_variant 0.16 pyrazinamide
clpC1 4038914 c.1791G>C synonymous_variant 0.16 pyrazinamide
clpC1 4038923 c.1780_1782delCTAinsTG frameshift_variant&synonymous_variant 0.16 pyrazinamide
clpC1 4038953 c.1752A>G synonymous_variant 0.17 pyrazinamide
clpC1 4038956 c.1749T>C synonymous_variant 0.21 pyrazinamide
clpC1 4038965 c.1740T>C synonymous_variant 0.21 pyrazinamide
clpC1 4038971 c.1734T>C synonymous_variant 0.2 pyrazinamide
clpC1 4038974 c.1731T>C synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
clpC1 4038989 c.1716T>C synonymous_variant 0.27 pyrazinamide
clpC1 4038997 c.1708T>C synonymous_variant 0.22 pyrazinamide Not assoc w R - Interim
clpC1 4039142 c.1563A>G synonymous_variant 0.21 pyrazinamide
clpC1 4039145 c.1560G>C synonymous_variant 0.21 pyrazinamide
clpC1 4039169 p.Glu512Asp missense_variant 0.17 pyrazinamide
clpC1 4039172 c.1533A>G synonymous_variant 0.19 pyrazinamide
clpC1 4039178 c.1527G>C synonymous_variant 0.19 pyrazinamide
clpC1 4039183 c.1522T>C synonymous_variant 0.19 pyrazinamide
clpC1 4039186 c.1519C>T synonymous_variant 0.2 pyrazinamide
clpC1 4039190 c.1515C>G synonymous_variant 0.19 pyrazinamide
clpC1 4039226 c.1479T>C synonymous_variant 0.15 pyrazinamide Not assoc w R - Interim
clpC1 4039229 c.1476C>G synonymous_variant 0.15 pyrazinamide
clpC1 4039391 c.1314T>G synonymous_variant 0.26 pyrazinamide
clpC1 4039409 c.1296T>C synonymous_variant 0.22 pyrazinamide
clpC1 4039412 c.1293T>G synonymous_variant 0.22 pyrazinamide
clpC1 4039415 p.Glu430Asp missense_variant 0.2 pyrazinamide Uncertain significance
clpC1 4039430 c.1275T>C synonymous_variant 0.21 pyrazinamide
clpC1 4039442 c.1263A>G synonymous_variant 0.16 pyrazinamide
clpC1 4039826 c.879C>G synonymous_variant 0.18 pyrazinamide
clpC1 4039831 c.874T>C synonymous_variant 0.17 pyrazinamide
clpC1 4039928 c.775_777delAGCinsTCG synonymous_variant 0.2 pyrazinamide
clpC1 4039931 c.774T>C synonymous_variant 0.2 pyrazinamide
clpC1 4039937 c.768G>C synonymous_variant 0.2 pyrazinamide
clpC1 4039946 c.759A>C synonymous_variant 0.2 pyrazinamide
clpC1 4039952 c.753T>C synonymous_variant 0.22 pyrazinamide
clpC1 4039982 c.723G>A synonymous_variant 0.22 pyrazinamide Not assoc w R - Interim
clpC1 4039988 c.717C>G synonymous_variant 0.23 pyrazinamide
clpC1 4039991 c.714G>C synonymous_variant 0.23 pyrazinamide
clpC1 4040225 c.480A>C synonymous_variant 0.23 pyrazinamide
clpC1 4040228 c.477G>T synonymous_variant 0.22 pyrazinamide
clpC1 4040237 c.468C>T synonymous_variant 0.23 pyrazinamide
clpC1 4040246 c.459C>G synonymous_variant 0.21 pyrazinamide
clpC1 4040249 c.456A>G synonymous_variant 0.24 pyrazinamide
clpC1 4040291 c.414G>C synonymous_variant 0.19 pyrazinamide
clpC1 4040387 c.318A>G synonymous_variant 0.17 pyrazinamide
clpC1 4040431 c.274T>C synonymous_variant 0.14 pyrazinamide
clpC1 4040444 c.261C>T synonymous_variant 0.23 pyrazinamide
clpC1 4040450 c.255A>G synonymous_variant 0.21 pyrazinamide Not assoc w R - Interim
clpC1 4040459 c.246C>G synonymous_variant 0.23 pyrazinamide
clpC1 4040465 c.240T>C synonymous_variant 0.23 pyrazinamide
clpC1 4040471 c.234T>C synonymous_variant 0.23 pyrazinamide Not assoc w R - Interim
panD 4044954 c.-674_-673delCCinsAT upstream_gene_variant 0.26 pyrazinamide
panD 4044980 c.-699A>G upstream_gene_variant 0.28 pyrazinamide
panD 4044983 c.-702G>T upstream_gene_variant 0.27 pyrazinamide
panD 4044989 c.-708T>C upstream_gene_variant 0.27 pyrazinamide
panD 4045000 c.-719A>C upstream_gene_variant 0.24 pyrazinamide
panD 4045001 c.-720G>C upstream_gene_variant 0.25 pyrazinamide
panD 4045019 c.-738G>C upstream_gene_variant 0.2 pyrazinamide
panD 4045022 c.-741C>G upstream_gene_variant 0.2 pyrazinamide
panD 4045028 c.-747C>G upstream_gene_variant 0.18 pyrazinamide
panD 4045034 c.-753A>C upstream_gene_variant 0.19 pyrazinamide
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
embC 4242803 p.Val981Leu missense_variant 1.0 ethambutol Not assoc w R
embB 4245740 c.-774T>C upstream_gene_variant 0.13 ethambutol
embB 4245764 c.-750G>C upstream_gene_variant 0.21 ethambutol
embA 4245772 p.Asn847Thr missense_variant 0.21 ethambutol
embA 4245785 c.2553G>C synonymous_variant 0.21 ethambutol Not assoc w R - Interim
embB 4246292 c.-222A>G upstream_gene_variant 0.21 ethambutol
embA 4246305 p.Ser1025Glu missense_variant 0.21 ethambutol
embA 4246308 p.Thr1026Ala missense_variant 0.23 ethambutol
embB 4246316 c.-198T>G upstream_gene_variant 0.22 ethambutol
embB 4246319 c.-195G>C upstream_gene_variant 0.22 ethambutol
embA 4246329 p.Thr1033Ala missense_variant 0.18 ethambutol
embB 4247395 c.882C>G synonymous_variant 0.21 ethambutol
embB 4247401 c.888T>C synonymous_variant 0.24 ethambutol
embB 4247407 c.894G>C synonymous_variant 0.23 ethambutol
embB 4247425 c.912G>C synonymous_variant 0.23 ethambutol
embB 4247434 c.921C>G synonymous_variant 0.23 ethambutol
embB 4247437 c.924A>G synonymous_variant 0.26 ethambutol Not assoc w R - Interim
embB 4247440 c.927C>G synonymous_variant 0.26 ethambutol
embB 4247446 c.933C>T synonymous_variant 0.25 ethambutol
embB 4247464 c.951C>G synonymous_variant 0.31 ethambutol
embB 4247470 c.957T>C synonymous_variant 0.32 ethambutol
embB 4247491 c.978G>C synonymous_variant 0.33 ethambutol
embB 4247497 c.984T>C synonymous_variant 0.33 ethambutol
embB 4247512 c.999T>C synonymous_variant 0.31 ethambutol
embB 4247539 c.1026T>C synonymous_variant 0.22 ethambutol
embB 4247554 c.1041T>C synonymous_variant 0.19 ethambutol
embB 4247566 c.1053C>A synonymous_variant 0.18 ethambutol
embB 4247572 c.1059A>G synonymous_variant 0.19 ethambutol
embB 4247579 p.Ala356Phe missense_variant 0.19 ethambutol
embB 4247587 c.1074G>A synonymous_variant 0.18 ethambutol
embB 4247588 c.1075_1077delCTAinsAC frameshift_variant&missense_variant 0.18 ethambutol
embB 4247603 c.1090C>T synonymous_variant 0.17 ethambutol
embB 4247773 c.1260G>A synonymous_variant 0.2 ethambutol
embB 4247776 c.1263G>T synonymous_variant 0.22 ethambutol
embB 4247797 c.1284C>G synonymous_variant 0.27 ethambutol
embB 4247800 c.1287A>T synonymous_variant 0.27 ethambutol
embB 4247803 c.1290G>C synonymous_variant 0.31 ethambutol
embB 4247815 c.1302C>G synonymous_variant 0.3 ethambutol
embB 4247819 c.1306_1308delGTTinsAC frameshift_variant&missense_variant 0.3 ethambutol
embB 4247830 c.1317A>G synonymous_variant 0.27 ethambutol Not assoc w R - Interim
embB 4247836 c.1323A>G synonymous_variant 0.3 ethambutol Not assoc w R - Interim
embB 4247839 c.1326G>C synonymous_variant 0.32 ethambutol Not assoc w R - Interim
embB 4247866 c.1353G>C synonymous_variant 0.34 ethambutol
embB 4247875 c.1362G>C synonymous_variant 0.31 ethambutol
embB 4247876 c.1363C>T synonymous_variant 0.32 ethambutol
embB 4247881 c.1368G>C synonymous_variant 0.32 ethambutol
embB 4247887 c.1374C>T synonymous_variant 0.33 ethambutol Not assoc w R - Interim
embB 4247893 c.1380C>T synonymous_variant 0.34 ethambutol
embB 4247899 p.Met462Ile missense_variant 0.31 ethambutol
embB 4247905 c.1392G>C synonymous_variant 0.31 ethambutol Not assoc w R - Interim
embB 4247909 c.1396T>C synonymous_variant 0.3 ethambutol
embB 4247914 c.1401G>C synonymous_variant 0.29 ethambutol Not assoc w R - Interim
embB 4247932 c.1419C>G synonymous_variant 0.28 ethambutol
embB 4247940 p.Leu476Trp missense_variant 0.27 ethambutol
embB 4247945 c.1432T>C synonymous_variant 0.26 ethambutol
embB 4247951 p.Ser480Ala missense_variant 0.27 ethambutol
embB 4247956 c.1443G>C synonymous_variant 0.2 ethambutol Not assoc w R - Interim
embB 4248007 c.1494C>G synonymous_variant 0.19 ethambutol
embB 4248011 p.Ser500Arg missense_variant 0.17 ethambutol
embB 4248014 p.Thr501Ala missense_variant 0.17 ethambutol Uncertain significance
embB 4248035 p.Val508Ile missense_variant 0.18 ethambutol
embB 4248040 c.1527C>G synonymous_variant 0.17 ethambutol
embB 4248041 p.Ala510Thr missense_variant 0.17 ethambutol Uncertain significance
embB 4248044 p.Lys511Ala missense_variant 0.18 ethambutol
embB 4248070 c.1557T>C synonymous_variant 0.16 ethambutol
embB 4248157 c.1644A>G synonymous_variant 0.14 ethambutol Not assoc w R - Interim
embB 4248220 c.1707A>C synonymous_variant 0.16 ethambutol
embB 4248304 c.1791G>C synonymous_variant 0.19 ethambutol
embB 4248316 c.1803C>G synonymous_variant 0.21 ethambutol
embB 4248319 c.1806A>G synonymous_variant 0.21 ethambutol
embB 4249408 c.2895G>A synonymous_variant 0.94 ethambutol Not assoc w R
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 capreomycin
amikacin
kanamycin