TB-Profiler result

Run: ERR11465025
Summary

Run ID: ERR11465025

Sample name:

Date: 2024-10-04T13:58:00.709017

Number of reads: 1138597

Percentage reads mapped: 93.41

Median coverage: 34.0

Strain: lineage4.1.1.3

Spoligotype:

Drug-resistance: Other

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage4.1 Euro-American None 1.0
lineage4.1.1.3 Euro-American (X-type) RD193 1.0
lineage4 Euro-American None 1.0
lineage4.1.1 Euro-American (X-type) None 1.0
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol embB p.His312Arg Mutation from literature
p.Leu359Ile Uncertain significance Mutation from literature
pyrazinamide
streptomycin rrs n.462C>T Uncertain significance Mutation from literature
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
rrs 1472307 n.462C>T non_coding_transcript_exon_variant 0.38 streptomycin Uncertain significance Mutation from literature
embB 4247448 p.His312Arg missense_variant 0.26 ethambutol Mutation from literature
embB 4247588 p.Leu359Ile missense_variant 0.18 ethambutol Uncertain significance Mutation from literature
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
gyrB 4982 c.-258C>G upstream_gene_variant 1.0 levofloxacin
moxifloxacin
gyrA 6703 c.-599G>C upstream_gene_variant 0.24 levofloxacin
moxifloxacin
gyrA 6709 c.-593A>G upstream_gene_variant 0.27 levofloxacin
moxifloxacin
gyrA 6712 c.-590G>C upstream_gene_variant 0.24 levofloxacin
moxifloxacin
gyrA 6728 c.-574_-572delCTAinsTTG upstream_gene_variant 0.27 levofloxacin
moxifloxacin
gyrA 6742 c.-560A>G upstream_gene_variant 0.26 levofloxacin
moxifloxacin
gyrB 6745 c.1506T>G synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6751 c.-551G>C upstream_gene_variant 0.26 levofloxacin
moxifloxacin
gyrA 6760 c.-542G>C upstream_gene_variant 0.25 levofloxacin
moxifloxacin
gyrB 6763 c.1524G>C synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6973 c.-329G>C upstream_gene_variant 0.17 levofloxacin
moxifloxacin
gyrA 6982 c.-320A>C upstream_gene_variant 0.18 levofloxacin
moxifloxacin
gyrA 7006 c.-296T>C upstream_gene_variant 0.18 levofloxacin
moxifloxacin
gyrA 7007 c.-295C>T upstream_gene_variant 0.18 levofloxacin
moxifloxacin
gyrA 7010 c.-292C>T upstream_gene_variant 0.18 levofloxacin
moxifloxacin
gyrA 7015 c.-287G>A upstream_gene_variant 0.18 levofloxacin
moxifloxacin
gyrA 7018 c.-284G>A upstream_gene_variant 0.18 levofloxacin
moxifloxacin
gyrB 7023 p.Leu595Gln missense_variant 0.15 levofloxacin
moxifloxacin
gyrA 7033 c.-269G>C upstream_gene_variant 0.17 levofloxacin
moxifloxacin
gyrB 7051 p.Glu604Asp missense_variant 0.16 levofloxacin
moxifloxacin
gyrA 7066 c.-236G>C upstream_gene_variant 0.15 levofloxacin
moxifloxacin
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 8294 c.993T>C synonymous_variant 0.14 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8324 c.1023T>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8330 c.1029C>G synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8339 c.1038A>G synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8340 p.Ala347Ser missense_variant 0.18 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8576 c.1275C>G synonymous_variant 0.13 levofloxacin
moxifloxacin
gyrA 8588 c.1287G>A synonymous_variant 0.14 levofloxacin
moxifloxacin
gyrA 8597 c.1296C>G synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8603 c.1302A>G synonymous_variant 0.14 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8619 c.1318_1320delTTGinsCTA synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8624 c.1323G>C synonymous_variant 0.14 levofloxacin
moxifloxacin
gyrA 8636 c.1335A>C synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8642 c.1341A>G synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8672 c.1371A>G synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9056 c.1755C>G synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9062 c.1761C>G synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 9068 c.1767G>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 9071 c.1770G>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 9080 c.1779G>T synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 9089 c.1788G>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 9099 c.1798_1800delTTAinsCTG synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 9104 c.1803C>G synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9119 c.1818A>G synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 9122 c.1821C>G synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9143 c.1842T>C synonymous_variant 0.34 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9152 c.1851C>T synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9153 p.Thr618Glu missense_variant 0.26 levofloxacin
moxifloxacin
gyrA 9158 c.1857C>T synonymous_variant 0.29 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9161 c.1860C>G synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 9182 c.1881T>C synonymous_variant 0.28 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9191 c.1890G>C synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 9200 c.1899A>G synonymous_variant 0.28 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9204 p.Ser635Thr missense_variant 0.29 levofloxacin
moxifloxacin
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
mshA 575566 c.219G>A synonymous_variant 1.0 isoniazid Not assoc w R - Interim
ethionamide Not assoc w R - Interim
Rv0565c 657269 p.Ser68Pro missense_variant 1.0 ethionamide Uncertain significance
hadA 731682 c.-248C>G upstream_gene_variant 0.17 isoniazid
hadA 731687 c.-243_-242insCACAGATCTTTT upstream_gene_variant 0.17 isoniazid
hadA 731693 c.-237C>A upstream_gene_variant 0.17 isoniazid
hadA 731696 c.-233_-232delTT upstream_gene_variant 0.18 isoniazid
hadA 731708 c.-222G>C upstream_gene_variant 0.22 isoniazid
hadA 731710 c.-220A>T upstream_gene_variant 0.23 isoniazid
hadA 731711 c.-219T>C upstream_gene_variant 0.23 isoniazid
hadA 731717 c.-213T>G upstream_gene_variant 0.23 isoniazid
hadA 731732 c.-198G>A upstream_gene_variant 0.24 isoniazid
hadA 731747 c.-183T>C upstream_gene_variant 0.26 isoniazid
hadA 731774 c.-156T>C upstream_gene_variant 0.17 isoniazid
rpoB 760091 c.285G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760101 c.295T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760112 c.306T>C synonymous_variant 0.19 rifampicin
rpoB 760118 c.312T>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760121 c.315T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760130 p.Asp108Glu missense_variant 0.22 rifampicin Uncertain significance
rpoB 760139 c.333A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760142 c.336C>G synonymous_variant 0.2 rifampicin
rpoB 760283 c.477G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760298 c.492G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 760307 c.501T>C synonymous_variant 0.2 rifampicin
rpoB 760310 c.504G>C synonymous_variant 0.19 rifampicin
rpoB 760328 c.522G>C synonymous_variant 0.2 rifampicin
rpoB 760331 c.525G>C synonymous_variant 0.2 rifampicin
rpoB 760340 c.534G>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760361 c.555T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760370 c.564C>G synonymous_variant 0.26 rifampicin
rpoB 760376 p.Asp190Glu missense_variant 0.26 rifampicin Uncertain significance
rpoB 760380 p.Thr192Leu missense_variant 0.23 rifampicin
rpoB 760406 c.600G>C synonymous_variant 0.22 rifampicin
rpoB 760412 c.606C>G synonymous_variant 0.22 rifampicin
rpoB 760424 c.618C>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760430 c.624T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760475 c.669A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760481 c.675G>T synonymous_variant 0.18 rifampicin
rpoB 760484 c.678A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760591 p.Val262Ala missense_variant 0.18 rifampicin
rpoB 760611 c.805T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 760670 c.864G>C synonymous_variant 0.15 rifampicin
rpoB 760715 c.909C>G synonymous_variant 0.16 rifampicin
rpoB 760718 c.912C>T synonymous_variant 0.16 rifampicin
rpoB 760925 c.1119T>C synonymous_variant 0.24 rifampicin
rpoB 760928 c.1122G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760931 c.1125C>G synonymous_variant 0.24 rifampicin
rpoB 760934 c.1128C>T synonymous_variant 0.24 rifampicin
rpoB 760946 c.1140A>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 760982 c.1176G>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 760985 c.1179G>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 760991 c.1185G>C synonymous_variant 0.34 rifampicin
rpoB 761006 c.1200C>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 761015 c.1209G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 761021 c.1215G>C synonymous_variant 0.27 rifampicin
rpoB 761027 c.1221A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 761036 c.1230G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 761037 c.1231T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 761057 c.1251G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 761408 c.1602G>C synonymous_variant 0.3 rifampicin
rpoB 761414 c.1608A>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 761423 c.1617T>C synonymous_variant 0.3 rifampicin
rpoB 761435 c.1629T>C synonymous_variant 0.29 rifampicin
rpoB 761438 c.1632G>C synonymous_variant 0.29 rifampicin
rpoB 761439 p.Asp545Lys missense_variant 0.29 rifampicin
rpoB 761444 c.1638T>C synonymous_variant 0.28 rifampicin
rpoB 761447 c.1641C>G synonymous_variant 0.28 rifampicin
rpoB 761452 p.Val549Glu missense_variant 0.28 rifampicin
rpoB 761457 p.Pro551Ser missense_variant 0.26 rifampicin
rpoB 761477 c.1671C>G synonymous_variant 0.28 rifampicin
rpoB 761492 c.1686G>C synonymous_variant 0.28 rifampicin
rpoB 761615 c.1809A>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 761645 c.1839C>G synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 761648 c.1842T>C synonymous_variant 0.14 rifampicin
rpoB 761657 c.1851C>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 761675 c.1869G>C synonymous_variant 0.23 rifampicin
rpoB 761747 c.1941G>C synonymous_variant 0.24 rifampicin
rpoB 761750 c.1944G>C synonymous_variant 0.25 rifampicin
rpoB 761765 c.1959T>C synonymous_variant 0.27 rifampicin
rpoB 761772 p.His656Ala missense_variant 0.27 rifampicin
rpoB 761778 p.Asn658Asp missense_variant 0.27 rifampicin
rpoB 761791 p.Arg662His missense_variant 0.25 rifampicin
rpoB 761885 c.2079T>C synonymous_variant 0.21 rifampicin
rpoB 761906 c.2100C>G synonymous_variant 0.16 rifampicin
rpoB 761909 c.2103T>C synonymous_variant 0.16 rifampicin
rpoB 761912 c.2106T>C synonymous_variant 0.17 rifampicin
rpoB 761915 p.Asp703Glu missense_variant 0.16 rifampicin
rpoB 761916 p.Asp704Asn missense_variant 0.16 rifampicin
rpoB 761948 c.2142G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 761954 c.2148C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 762008 c.2202C>T synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 762014 c.2208C>T synonymous_variant 0.31 rifampicin
rpoB 762017 c.2211A>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 762053 c.2247T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 762062 c.2256T>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 762083 c.2277T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 762086 c.2280G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 762101 c.2295C>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 762114 p.Ile770Val missense_variant 0.27 rifampicin Uncertain significance
rpoB 762176 c.2370T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 762185 c.2379G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 762206 c.2400C>G synonymous_variant 0.38 rifampicin
rpoB 762233 c.2427G>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 762246 c.2440C>T synonymous_variant 0.33 rifampicin
rpoB 762254 c.2448T>G synonymous_variant 0.33 rifampicin
rpoB 762257 c.2451C>G synonymous_variant 0.33 rifampicin
rpoB 762266 c.2460T>C synonymous_variant 0.27 rifampicin
rpoB 762284 c.2478G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 762293 c.2487T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 762314 c.2508C>T synonymous_variant 0.22 rifampicin
rpoB 762317 c.2511A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 762329 c.2523G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 762338 c.2532T>C synonymous_variant 0.2 rifampicin
rpoB 762347 c.2541T>C synonymous_variant 0.24 rifampicin
rpoB 762359 c.2553C>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 762362 p.Glu852Asp missense_variant 0.2 rifampicin
rpoB 762369 c.2563T>C synonymous_variant 0.22 rifampicin
rpoC 762398 c.-972T>C upstream_gene_variant 0.26 rifampicin
rpoC 762401 c.-969G>C upstream_gene_variant 0.27 rifampicin
rpoB 762404 c.2598T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 762410 c.-960T>C upstream_gene_variant 0.31 rifampicin
rpoB 762416 c.2610A>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 762419 c.-951C>G upstream_gene_variant 0.32 rifampicin
rpoC 762434 c.-936T>C upstream_gene_variant 0.35 rifampicin
rpoB 762449 c.2643C>A synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 762467 c.-903C>T upstream_gene_variant 0.36 rifampicin
rpoC 763570 c.201G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 763573 c.204G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 763594 c.225C>T synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 763603 c.234C>T synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 763636 c.267T>C synonymous_variant 0.27 rifampicin
rpoC 763657 c.288G>A synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 763660 c.291T>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 763675 c.306C>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 763696 c.327T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 763702 c.333C>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 763717 c.348T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 763723 c.354G>C synonymous_variant 0.26 rifampicin
rpoC 763732 c.363C>G synonymous_variant 0.28 rifampicin
rpoC 763741 c.372C>T synonymous_variant 0.28 rifampicin
rpoC 763744 c.375G>C synonymous_variant 0.27 rifampicin
rpoC 763765 c.396T>C synonymous_variant 0.39 rifampicin
rpoC 763774 c.405G>C synonymous_variant 0.39 rifampicin
rpoC 763807 c.438T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 763816 c.447C>G synonymous_variant 0.33 rifampicin
rpoC 763835 p.Ala156Met missense_variant 0.26 rifampicin
rpoC 763853 p.Val162Ile missense_variant 0.28 rifampicin
rpoC 763858 c.489A>G synonymous_variant 0.29 rifampicin
rpoC 763872 p.Gly168Ala missense_variant 0.26 rifampicin
rpoC 763876 p.Glu169Asp missense_variant 0.27 rifampicin
rpoC 763879 c.510A>G synonymous_variant 0.27 rifampicin
rpoC 763888 c.519G>C synonymous_variant 0.2 rifampicin
rpoC 763891 c.522G>C synonymous_variant 0.2 rifampicin
rpoC 763894 c.525A>G synonymous_variant 0.21 rifampicin
rpoC 763900 c.531G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764024 c.655_657delTTGinsCTC synonymous_variant 0.32 rifampicin
rpoC 764032 p.Asp221Glu missense_variant 0.33 rifampicin
rpoC 764040 p.Ser224Thr missense_variant 0.31 rifampicin
rpoC 764044 c.675T>C synonymous_variant 0.31 rifampicin
rpoC 764059 c.690G>T synonymous_variant 0.31 rifampicin
rpoC 764083 c.714A>G synonymous_variant 0.3 rifampicin
rpoC 764098 c.729A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 764101 c.732C>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764102 p.Val245Ile missense_variant 0.29 rifampicin
rpoC 764112 p.Tyr248Phe missense_variant 0.38 rifampicin
rpoC 764116 c.747C>T synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 764131 c.762T>C synonymous_variant 0.28 rifampicin
rpoC 764188 c.819A>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 764195 p.Ser276Ile missense_variant 0.34 rifampicin
rpoC 764203 c.834G>C synonymous_variant 0.35 rifampicin
rpoC 764206 c.837T>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 764215 c.846A>G synonymous_variant 0.4 rifampicin
rpoC 764236 c.867G>A synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 764248 c.879C>G synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 764257 c.888G>C synonymous_variant 0.35 rifampicin
rpoC 764266 c.897T>C synonymous_variant 0.34 rifampicin
rpoC 764269 c.900G>C synonymous_variant 0.37 rifampicin
rpoC 764272 c.903G>C synonymous_variant 0.36 rifampicin
rpoC 764278 c.909A>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 764353 c.984G>C synonymous_variant 0.3 rifampicin
rpoC 764428 c.1059G>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 764431 c.1062G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 764434 c.1065A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764446 c.1077T>C synonymous_variant 0.15 rifampicin
rpoC 764458 c.1089G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764461 c.1092A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764489 c.1120C>T synonymous_variant 0.2 rifampicin
rpoC 764497 c.1128A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764510 c.1141C>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 764521 c.1152T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764527 c.1158C>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 764536 c.1167G>C synonymous_variant 0.29 rifampicin
rpoC 764539 c.1170C>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 764548 c.1179G>A synonymous_variant 0.56 rifampicin
rpoC 764551 c.1182G>C synonymous_variant 0.53 rifampicin
rpoC 764554 c.1185C>T synonymous_variant 0.48 rifampicin
rpoC 764560 c.1191T>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 764566 c.1197C>G synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 764575 c.1206T>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 764593 c.1224C>T synonymous_variant 0.39 rifampicin
rpoC 764611 c.1242G>T synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>C synonymous_variant 0.23 rifampicin
rpoC 764651 c.1282_1284delTCGinsAGC synonymous_variant 0.24 rifampicin
rpoC 764815 c.1446A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 764827 c.1458G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764858 c.1489T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 764872 c.1503A>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764888 c.1519T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 764911 c.1542A>G synonymous_variant 0.3 rifampicin
rpoC 764932 c.1563C>A synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764948 c.1579T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 765150 p.Gly594Glu missense_variant 1.0 rifampicin Not assoc w R
rpoC 765700 c.2331T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 765734 c.2365T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 765739 c.2370G>T synonymous_variant 0.2 rifampicin
rpoC 765751 c.2382C>G synonymous_variant 0.2 rifampicin
rpoC 765753 p.Asp795Ala missense_variant 0.2 rifampicin Uncertain significance
rpoC 765772 c.2403C>G synonymous_variant 0.29 rifampicin
rpoC 765784 c.2415C>G synonymous_variant 0.28 rifampicin
rpoC 765787 c.2418C>T synonymous_variant 0.3 rifampicin
rpoC 765793 c.2424C>G synonymous_variant 0.28 rifampicin
rpoC 765796 c.2427C>T synonymous_variant 0.29 rifampicin
rpoC 765811 c.2442T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 765814 c.2445A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 766327 c.2958C>A synonymous_variant 0.15 rifampicin
rpoC 766345 c.2976T>C synonymous_variant 0.19 rifampicin
rpoC 766348 c.2979A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 766357 c.2988C>T synonymous_variant 0.2 rifampicin
rpoC 766363 c.2994G>C synonymous_variant 0.21 rifampicin
rpoC 766366 c.2997C>G synonymous_variant 0.21 rifampicin
rpoC 766381 c.3012C>T synonymous_variant 0.26 rifampicin
rpoC 766384 c.3015A>G synonymous_variant 0.28 rifampicin
rpoC 766390 c.3021C>T synonymous_variant 0.25 rifampicin
rpoC 766393 c.3024C>G synonymous_variant 0.25 rifampicin
rpoC 766522 c.3153C>G synonymous_variant 0.14 rifampicin
rpoC 766531 c.3162G>C synonymous_variant 0.15 rifampicin
rpoC 766594 c.3225G>C synonymous_variant 0.18 rifampicin
rpoC 766597 c.3228C>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 766607 p.Ile1080Leu missense_variant 0.22 rifampicin
rpoC 766630 c.3261G>C synonymous_variant 0.23 rifampicin
rpoC 766657 c.3288A>G synonymous_variant 0.22 rifampicin
rpoC 766672 c.3303T>C synonymous_variant 0.18 rifampicin
rpoC 766673 p.Gly1102Asn missense_variant 0.18 rifampicin
rpoC 766726 c.3357T>C synonymous_variant 0.21 rifampicin
rpoC 766738 c.3369G>C synonymous_variant 0.24 rifampicin
rpoC 766765 c.3396A>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 766774 c.3405T>C synonymous_variant 0.28 rifampicin
rpoC 766801 c.3432C>G synonymous_variant 0.26 rifampicin
rpoC 766804 c.3435A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 766861 c.3492G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 766864 c.3495G>C synonymous_variant 0.25 rifampicin
rpoC 766933 c.3564A>G synonymous_variant 0.29 rifampicin
rpoC 766945 c.3576A>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 766963 c.3594T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 766972 c.3603G>C synonymous_variant 0.32 rifampicin
rpoC 766996 c.3627C>T synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 767059 c.3690T>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 767062 c.3693C>A synonymous_variant 0.19 rifampicin
mmpL5 775639 p.Ile948Val missense_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781655 c.96T>C synonymous_variant 0.28 streptomycin
rpsL 781736 c.177T>C synonymous_variant 0.29 streptomycin
rpsL 781742 c.183C>T synonymous_variant 0.25 streptomycin
rpsL 781754 c.195G>C synonymous_variant 0.31 streptomycin
rpsL 781760 c.201T>C synonymous_variant 0.29 streptomycin
rpsL 781772 c.213C>A synonymous_variant 0.31 streptomycin
rpsL 781808 c.249C>T synonymous_variant 0.29 streptomycin
rpsL 781811 c.252C>T synonymous_variant 0.29 streptomycin
rpsL 781832 c.273T>C synonymous_variant 0.26 streptomycin
rpsL 781838 c.279G>C synonymous_variant 0.28 streptomycin
rpsL 781841 c.282C>G synonymous_variant 0.27 streptomycin
rpsL 781865 c.306G>C synonymous_variant 0.26 streptomycin
rpsL 781868 c.309T>C synonymous_variant 0.25 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.25 streptomycin
rpsL 781877 c.318T>C synonymous_variant 0.27 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.23 streptomycin
rpsL 781898 c.339A>T synonymous_variant 0.23 streptomycin
rpsL 781916 c.357T>C synonymous_variant 0.28 streptomycin
rpsL 781929 p.Gly124Ser missense_variant 0.24 streptomycin Uncertain significance
rplC 800219 c.-590T>C upstream_gene_variant 1.0 linezolid
rplC 800516 c.-293G>T upstream_gene_variant 0.25 linezolid
rplC 800537 c.-272C>T upstream_gene_variant 0.31 linezolid
rplC 800540 c.-269T>C upstream_gene_variant 0.3 linezolid
rplC 800546 c.-263T>G upstream_gene_variant 0.32 linezolid
rplC 800567 c.-242A>G upstream_gene_variant 0.33 linezolid
rplC 800582 c.-227C>G upstream_gene_variant 0.35 linezolid
rplC 800612 c.-197A>G upstream_gene_variant 0.37 linezolid
rplC 800618 c.-191T>C upstream_gene_variant 0.4 linezolid
rplC 800627 c.-182C>T upstream_gene_variant 0.4 linezolid
rplC 800648 c.-161A>T upstream_gene_variant 0.32 linezolid
rplC 800654 c.-155T>C upstream_gene_variant 0.33 linezolid
rplC 800693 c.-116A>G upstream_gene_variant 0.25 linezolid
rplC 800703 c.-106T>C upstream_gene_variant 0.25 linezolid
rplC 800715 c.-94A>C upstream_gene_variant 0.23 linezolid
rplC 800720 c.-89T>C upstream_gene_variant 0.24 linezolid
rplC 800723 c.-86C>G upstream_gene_variant 0.24 linezolid
rplC 800747 c.-62C>G upstream_gene_variant 0.24 linezolid
rplC 800771 c.-38C>T upstream_gene_variant 0.25 linezolid
rplC 800794 c.-15A>G upstream_gene_variant 0.23 linezolid
rplC 800796 c.-13A>G upstream_gene_variant 0.23 linezolid
rplC 800798 c.-10_-9delGG upstream_gene_variant 0.23 linezolid
rplC 800814 c.6A>G synonymous_variant 0.22 linezolid
rplC 800817 c.9A>T synonymous_variant 0.19 linezolid
rplC 801339 c.531T>C synonymous_variant 0.17 linezolid
rplC 801341 p.Leu178Gln missense_variant 0.17 linezolid
rplC 801348 c.540T>G synonymous_variant 0.18 linezolid
rplC 801357 c.549T>C synonymous_variant 0.17 linezolid
rplC 801367 p.Ala187Thr missense_variant 0.17 linezolid
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 kanamycin
capreomycin
streptomycin
amikacin
rrs 1471969 n.124T>C non_coding_transcript_exon_variant 0.36 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1471970 n.125G>A non_coding_transcript_exon_variant 0.39 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472028 n.183A>T non_coding_transcript_exon_variant 0.18 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472029 n.184C>T non_coding_transcript_exon_variant 0.21 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472030 n.185G>T non_coding_transcript_exon_variant 0.21 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472031 n.186G>A non_coding_transcript_exon_variant 0.2 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472033 n.188A>G non_coding_transcript_exon_variant 0.19 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472034 n.189T>C non_coding_transcript_exon_variant 0.19 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472044 n.199G>T non_coding_transcript_exon_variant 0.22 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472045 n.200T>A non_coding_transcript_exon_variant 0.21 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472053 n.211_212delGC non_coding_transcript_exon_variant 0.21 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472061 n.216A>T non_coding_transcript_exon_variant 0.21 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472075 n.230A>G non_coding_transcript_exon_variant 0.24 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.26 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473105 n.1260G>A non_coding_transcript_exon_variant 0.33 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1473123 n.1278delAinsTT non_coding_transcript_exon_variant 0.31 kanamycin
capreomycin
streptomycin
amikacin
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.37 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473290 n.1445C>T non_coding_transcript_exon_variant 0.29 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrl 1473668 n.11C>T non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid
rrl 1473756 n.99G>A non_coding_transcript_exon_variant 0.53 capreomycin
linezolid
rrl 1473758 n.101G>T non_coding_transcript_exon_variant 0.54 capreomycin Uncertain significance
linezolid
rrl 1473806 n.149C>T non_coding_transcript_exon_variant 0.53 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473877 n.220G>A non_coding_transcript_exon_variant 0.58 capreomycin
linezolid
rrl 1473898 n.241C>T non_coding_transcript_exon_variant 0.55 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473943 n.286G>T non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid
rrl 1473945 n.288T>A non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid
rrl 1473946 n.289A>T non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid
rrl 1473986 n.329T>C non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1473987 n.330G>A non_coding_transcript_exon_variant 0.35 capreomycin
linezolid
rrl 1473995 n.338G>T non_coding_transcript_exon_variant 0.5 capreomycin
linezolid
rrl 1474001 n.344C>T non_coding_transcript_exon_variant 0.52 capreomycin Not assoc w R
linezolid Not assoc w R
rrl 1474009 n.352A>G non_coding_transcript_exon_variant 0.55 capreomycin
linezolid
rrl 1474012 n.355C>T non_coding_transcript_exon_variant 0.47 capreomycin
linezolid
rrl 1474093 n.436G>T non_coding_transcript_exon_variant 0.46 capreomycin
linezolid
rrl 1474099 n.442G>A non_coding_transcript_exon_variant 0.4 capreomycin
linezolid
rrl 1474103 n.446A>T non_coding_transcript_exon_variant 0.38 capreomycin
linezolid
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474181 n.524C>T non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid
rrl 1474356 n.699T>C non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid
rrl 1474362 n.705A>G non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474376 n.719T>C non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1474639 n.982G>A non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474823 n.1166C>T non_coding_transcript_exon_variant 0.42 capreomycin
linezolid
rrl 1474831 n.1174A>G non_coding_transcript_exon_variant 0.45 capreomycin Uncertain significance
linezolid
rrl 1475199 n.1542G>A non_coding_transcript_exon_variant 0.54 capreomycin
linezolid
rrl 1475206 n.1549C>T non_coding_transcript_exon_variant 0.59 capreomycin Uncertain significance
linezolid
rrl 1475209 n.1552G>C non_coding_transcript_exon_variant 0.58 capreomycin Uncertain significance
linezolid
rrl 1475213 n.1556C>T non_coding_transcript_exon_variant 0.6 capreomycin Uncertain significance
linezolid
rrl 1475249 n.1592T>C non_coding_transcript_exon_variant 0.48 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475252 n.1595C>T non_coding_transcript_exon_variant 0.44 capreomycin
linezolid
rrl 1475266 n.1609T>C non_coding_transcript_exon_variant 0.48 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475267 n.1610G>A non_coding_transcript_exon_variant 0.48 capreomycin
linezolid
rrl 1475275 n.1618C>T non_coding_transcript_exon_variant 0.41 capreomycin
linezolid
rrl 1475276 n.1619T>C non_coding_transcript_exon_variant 0.41 capreomycin
linezolid
rrl 1475291 n.1634A>C non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475355 n.1698C>T non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475369 n.1712G>T non_coding_transcript_exon_variant 0.38 capreomycin
linezolid
rrl 1475402 n.1745C>T non_coding_transcript_exon_variant 0.42 capreomycin
linezolid
rrl 1475419 n.1762C>T non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid
rrl 1475429 n.1772G>A non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475436 n.1779C>T non_coding_transcript_exon_variant 0.41 capreomycin
linezolid
rrl 1475483 n.1826C>T non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475505 n.1848G>A non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475599 n.1942A>G non_coding_transcript_exon_variant 0.57 capreomycin
linezolid Uncertain significance
rrl 1475608 n.1951T>C non_coding_transcript_exon_variant 0.54 capreomycin Uncertain significance
linezolid
rrl 1475642 n.1985T>C non_coding_transcript_exon_variant 0.42 capreomycin
linezolid
rrl 1475657 n.2000A>G non_coding_transcript_exon_variant 0.41 capreomycin
linezolid
rrl 1475659 n.2002G>T non_coding_transcript_exon_variant 0.41 capreomycin
linezolid
rrl 1475761 n.2104_2106delCGCinsGT non_coding_transcript_exon_variant 0.46 capreomycin
linezolid
rrl 1475765 n.2111delG non_coding_transcript_exon_variant 0.5 capreomycin
linezolid
rrl 1475881 n.2224T>C non_coding_transcript_exon_variant 0.55 capreomycin
linezolid
rrl 1476214 n.2557G>A non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.43 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.26 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476594 n.2937C>T non_coding_transcript_exon_variant 0.26 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476597 n.2940G>A non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid
rrl 1476603 n.2946G>A non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476608 n.2951C>G non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476689 n.3032A>T non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1476690 n.3033C>T non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid
rrl 1476693 n.3036G>A non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1476695 n.3038T>A non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1476716 n.3059A>C non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid
rrl 1476726 n.3069A>G non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
inhA 1674582 c.381T>C synonymous_variant 0.17 isoniazid
ethionamide
inhA 1674585 c.384T>C synonymous_variant 0.17 isoniazid
ethionamide
inhA 1674589 p.Met130Leu missense_variant 0.17 isoniazid
ethionamide
inhA 1674601 p.Leu134Thr missense_variant 0.19 isoniazid
ethionamide
inhA 1674624 c.423A>C synonymous_variant 0.22 isoniazid
ethionamide
inhA 1674630 c.429C>G synonymous_variant 0.2 isoniazid
ethionamide
inhA 1674672 c.471C>G synonymous_variant 0.24 isoniazid
ethionamide
inhA 1674703 c.502T>C synonymous_variant 0.2 isoniazid
ethionamide
inhA 1674708 c.507G>A synonymous_variant 0.17 isoniazid
ethionamide
inhA 1674718 c.517A>C synonymous_variant 0.2 isoniazid
ethionamide
inhA 1674723 c.522C>T synonymous_variant 0.18 isoniazid Not assoc w R - Interim
ethionamide Not assoc w R - Interim
rpsA 1833532 c.-10A>C upstream_gene_variant 0.14 pyrazinamide
rpsA 1833554 p.Thr5Ala missense_variant 0.18 pyrazinamide Uncertain significance
rpsA 1833568 c.27G>C synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
rpsA 1833589 c.48A>T synonymous_variant 0.19 pyrazinamide
rpsA 1833595 c.54T>C synonymous_variant 0.19 pyrazinamide
rpsA 1833661 c.120A>G synonymous_variant 0.31 pyrazinamide
rpsA 1833667 c.126C>G synonymous_variant 0.34 pyrazinamide
rpsA 1833721 c.180A>G synonymous_variant 0.29 pyrazinamide
rpsA 1833724 c.183C>G synonymous_variant 0.29 pyrazinamide
rpsA 1833727 c.186G>C synonymous_variant 0.26 pyrazinamide
rpsA 1833742 c.201A>G synonymous_variant 0.27 pyrazinamide
rpsA 1833745 c.204G>C synonymous_variant 0.28 pyrazinamide
rpsA 1833748 c.207C>G synonymous_variant 0.28 pyrazinamide
rpsA 1833874 c.333T>C synonymous_variant 0.34 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.38 pyrazinamide
rpsA 1833940 c.399C>G synonymous_variant 0.31 pyrazinamide
rpsA 1833971 c.430C>T synonymous_variant 0.26 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.24 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.26 pyrazinamide
rpsA 1834021 c.480C>T synonymous_variant 0.24 pyrazinamide
rpsA 1834540 c.999G>C synonymous_variant 0.17 pyrazinamide
rpsA 1834546 c.1005T>C synonymous_variant 0.17 pyrazinamide
rpsA 1834609 c.1068T>C synonymous_variant 0.21 pyrazinamide
rpsA 1834633 c.1092A>G synonymous_variant 0.24 pyrazinamide
rpsA 1834639 c.1098T>C synonymous_variant 0.23 pyrazinamide
rpsA 1834654 p.Glu371Asp missense_variant 0.31 pyrazinamide
rpsA 1834732 c.1191T>C synonymous_variant 0.27 pyrazinamide
rpsA 1834733 p.Ala398Ser missense_variant 0.27 pyrazinamide
rpsA 1834738 c.1197A>G synonymous_variant 0.26 pyrazinamide
rpsA 1834753 c.1212T>C synonymous_variant 0.25 pyrazinamide
rpsA 1834775 p.Ala412Thr missense_variant 0.22 pyrazinamide
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
kasA 2517950 c.-165C>G upstream_gene_variant 0.34 isoniazid
eis 2715620 c.-288C>T upstream_gene_variant 1.0 kanamycin
amikacin
Rv2477c 2783656 c.387G>C synonymous_variant 0.19 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783665 c.378A>G synonymous_variant 0.22 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783674 c.369T>C synonymous_variant 0.21 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783883 c.160T>C synonymous_variant 0.32 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783884 c.159T>C synonymous_variant 0.32 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783887 c.156C>G synonymous_variant 0.33 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783914 c.129T>C synonymous_variant 0.39 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
mtrB 3625065 p.Met517Leu missense_variant 1.0 rifampicin Not assoc w R
bedaquiline Uncertain significance
mtrB 3625636 c.978C>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
bedaquiline
fbiB 3641298 c.-237G>A upstream_gene_variant 1.0 pretomanid
delamanid
clofazimine
rpoA 3877571 p.Pro313Ala missense_variant 0.16 rifampicin
rpoA 3877587 c.921A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3877613 p.Ile299Val missense_variant 0.35 rifampicin
rpoA 3877656 c.852T>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoA 3877668 c.840A>G synonymous_variant 0.31 rifampicin
rpoA 3877679 p.Ala277Ser missense_variant 0.3 rifampicin
rpoA 3877686 c.822A>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoA 3877692 c.816G>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoA 3877704 c.804G>C synonymous_variant 0.29 rifampicin
rpoA 3877737 c.771G>C synonymous_variant 0.26 rifampicin
rpoA 3877743 c.765T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoA 3878761 c.-254G>C upstream_gene_variant 0.25 rifampicin
rpoA 3878764 c.-257A>G upstream_gene_variant 0.26 rifampicin
rpoA 3878785 c.-278T>G upstream_gene_variant 0.28 rifampicin
rpoA 3878788 c.-281G>C upstream_gene_variant 0.28 rifampicin Uncertain significance
rpoA 3878806 c.-299C>G upstream_gene_variant 0.24 rifampicin
rpoA 3878809 c.-302T>C upstream_gene_variant 0.24 rifampicin
rpoA 3878824 c.-317G>C upstream_gene_variant 0.27 rifampicin
rpoA 3878833 c.-326C>G upstream_gene_variant 0.24 rifampicin
rpoA 3878836 c.-331_-329delAAGinsTCC upstream_gene_variant 0.2 rifampicin
rpoA 3878853 c.-346G>A upstream_gene_variant 0.26 rifampicin
rpoA 3878878 c.-371T>C upstream_gene_variant 0.21 rifampicin Uncertain significance
rpoA 3878909 c.-402A>G upstream_gene_variant 0.2 rifampicin
rpoA 3878914 c.-407T>C upstream_gene_variant 0.17 rifampicin Uncertain significance
rpoA 3878917 c.-410G>A upstream_gene_variant 0.16 rifampicin Uncertain significance
rpoA 3878938 c.-431T>C upstream_gene_variant 0.14 rifampicin
rpoA 3878947 c.-440G>C upstream_gene_variant 0.15 rifampicin Uncertain significance
rpoA 3878968 c.-461T>C upstream_gene_variant 0.18 rifampicin Uncertain significance
rpoA 3878976 c.-469A>G upstream_gene_variant 0.18 rifampicin Uncertain significance
rpoA 3878986 c.-479G>C upstream_gene_variant 0.18 rifampicin
rpoA 3878998 c.-491C>G upstream_gene_variant 0.21 rifampicin Uncertain significance
rpoA 3879005 c.-499_-498delAAinsCG upstream_gene_variant 0.18 rifampicin
rpoA 3879013 c.-506A>G upstream_gene_variant 0.19 rifampicin
clpC1 4038356 c.2349T>C synonymous_variant 0.15 pyrazinamide
clpC1 4038359 c.2346A>G synonymous_variant 0.16 pyrazinamide
clpC1 4038368 c.2337T>C synonymous_variant 0.22 pyrazinamide
clpC1 4038392 c.2313C>T synonymous_variant 0.14 pyrazinamide
clpC1 4038683 c.2022T>C synonymous_variant 0.15 pyrazinamide Not assoc w R - Interim
clpC1 4038695 c.2010C>G synonymous_variant 0.2 pyrazinamide
clpC1 4038701 c.2004G>C synonymous_variant 0.2 pyrazinamide
clpC1 4038704 c.2001T>C synonymous_variant 0.18 pyrazinamide
clpC1 4038707 c.1998C>G synonymous_variant 0.18 pyrazinamide
clpC1 4038710 c.1995G>C synonymous_variant 0.18 pyrazinamide
clpC1 4038713 c.1992T>C synonymous_variant 0.17 pyrazinamide
clpC1 4038749 c.1956C>G synonymous_variant 0.18 pyrazinamide
clpC1 4038755 c.1950G>T synonymous_variant 0.19 pyrazinamide
clpC1 4038770 c.1935C>T synonymous_variant 0.17 pyrazinamide
clpC1 4038773 c.1932T>C synonymous_variant 0.17 pyrazinamide
clpC1 4038782 c.1923G>C synonymous_variant 0.18 pyrazinamide
clpC1 4038812 c.1893T>C synonymous_variant 0.14 pyrazinamide
clpC1 4038860 c.1845G>C synonymous_variant 0.23 pyrazinamide Not assoc w R - Interim
clpC1 4038878 c.1827A>G synonymous_variant 0.24 pyrazinamide Not assoc w R - Interim
clpC1 4038908 c.1797C>G synonymous_variant 0.16 pyrazinamide
clpC1 4038914 c.1791G>C synonymous_variant 0.16 pyrazinamide
clpC1 4038923 c.1780_1782delCTAinsTTG synonymous_variant 0.16 pyrazinamide
clpC1 4038953 c.1752A>G synonymous_variant 0.17 pyrazinamide
clpC1 4038956 c.1749T>C synonymous_variant 0.21 pyrazinamide
clpC1 4038965 c.1740T>C synonymous_variant 0.21 pyrazinamide
clpC1 4038971 c.1734T>C synonymous_variant 0.2 pyrazinamide
clpC1 4038974 c.1731T>C synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
clpC1 4038989 c.1716T>C synonymous_variant 0.27 pyrazinamide
clpC1 4038997 c.1708T>C synonymous_variant 0.22 pyrazinamide Not assoc w R - Interim
clpC1 4039142 c.1563A>G synonymous_variant 0.21 pyrazinamide
clpC1 4039145 c.1560G>C synonymous_variant 0.21 pyrazinamide
clpC1 4039169 p.Glu512Asp missense_variant 0.17 pyrazinamide
clpC1 4039172 c.1533A>G synonymous_variant 0.19 pyrazinamide
clpC1 4039178 c.1527G>C synonymous_variant 0.19 pyrazinamide
clpC1 4039183 c.1522T>C synonymous_variant 0.19 pyrazinamide
clpC1 4039186 c.1519C>T synonymous_variant 0.2 pyrazinamide
clpC1 4039190 c.1515C>G synonymous_variant 0.19 pyrazinamide
clpC1 4039226 c.1479T>C synonymous_variant 0.15 pyrazinamide Not assoc w R - Interim
clpC1 4039229 c.1476C>G synonymous_variant 0.15 pyrazinamide
clpC1 4039391 c.1314T>G synonymous_variant 0.26 pyrazinamide
clpC1 4039409 c.1296T>C synonymous_variant 0.22 pyrazinamide
clpC1 4039412 c.1293T>G synonymous_variant 0.22 pyrazinamide
clpC1 4039415 p.Glu430Asp missense_variant 0.2 pyrazinamide Uncertain significance
clpC1 4039430 c.1275T>C synonymous_variant 0.21 pyrazinamide
clpC1 4039442 c.1263A>G synonymous_variant 0.16 pyrazinamide
clpC1 4039826 c.879C>G synonymous_variant 0.18 pyrazinamide
clpC1 4039831 c.874T>C synonymous_variant 0.17 pyrazinamide
clpC1 4039928 c.775_777delAGCinsTCG synonymous_variant 0.2 pyrazinamide
clpC1 4039931 c.774T>C synonymous_variant 0.2 pyrazinamide
clpC1 4039937 c.768G>C synonymous_variant 0.2 pyrazinamide
clpC1 4039946 c.759A>C synonymous_variant 0.2 pyrazinamide
clpC1 4039952 c.753T>C synonymous_variant 0.22 pyrazinamide
clpC1 4039982 c.723G>A synonymous_variant 0.22 pyrazinamide Not assoc w R - Interim
clpC1 4039988 c.717C>G synonymous_variant 0.23 pyrazinamide
clpC1 4039991 c.714G>C synonymous_variant 0.23 pyrazinamide
clpC1 4040225 c.480A>C synonymous_variant 0.23 pyrazinamide
clpC1 4040228 c.477G>T synonymous_variant 0.22 pyrazinamide
clpC1 4040237 c.468C>T synonymous_variant 0.23 pyrazinamide
clpC1 4040246 c.459C>G synonymous_variant 0.21 pyrazinamide
clpC1 4040249 c.456A>G synonymous_variant 0.24 pyrazinamide
clpC1 4040291 c.414G>C synonymous_variant 0.19 pyrazinamide
clpC1 4040387 c.318A>G synonymous_variant 0.17 pyrazinamide
clpC1 4040431 c.274T>C synonymous_variant 0.14 pyrazinamide
clpC1 4040444 c.261C>T synonymous_variant 0.23 pyrazinamide
clpC1 4040450 c.255A>G synonymous_variant 0.21 pyrazinamide Not assoc w R - Interim
clpC1 4040459 c.246C>G synonymous_variant 0.23 pyrazinamide
clpC1 4040465 c.240T>C synonymous_variant 0.23 pyrazinamide
clpC1 4040471 c.234T>C synonymous_variant 0.23 pyrazinamide Not assoc w R - Interim
panD 4044954 c.-674_-673delCCinsAT upstream_gene_variant 0.26 pyrazinamide
panD 4044980 c.-699A>G upstream_gene_variant 0.28 pyrazinamide
panD 4044983 c.-702G>T upstream_gene_variant 0.27 pyrazinamide
panD 4044989 c.-708T>C upstream_gene_variant 0.27 pyrazinamide
panD 4045000 c.-719A>C upstream_gene_variant 0.24 pyrazinamide
panD 4045001 c.-720G>C upstream_gene_variant 0.25 pyrazinamide
panD 4045019 c.-738G>C upstream_gene_variant 0.2 pyrazinamide
panD 4045022 c.-741C>G upstream_gene_variant 0.2 pyrazinamide
panD 4045028 c.-747C>G upstream_gene_variant 0.18 pyrazinamide
panD 4045034 c.-753A>C upstream_gene_variant 0.19 pyrazinamide
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
embC 4242803 p.Val981Leu missense_variant 1.0 ethambutol Not assoc w R
embB 4245740 c.-774T>C upstream_gene_variant 0.13 ethambutol
embB 4245764 c.-750G>C upstream_gene_variant 0.21 ethambutol
embA 4245772 p.Asn847Thr missense_variant 0.21 ethambutol
embA 4245785 c.2553G>C synonymous_variant 0.21 ethambutol Not assoc w R - Interim
embB 4246292 c.-222A>G upstream_gene_variant 0.21 ethambutol
embA 4246305 p.Ser1025Glu missense_variant 0.21 ethambutol
embA 4246308 p.Thr1026Ala missense_variant 0.23 ethambutol
embB 4246316 c.-198T>G upstream_gene_variant 0.22 ethambutol
embB 4246319 c.-195G>C upstream_gene_variant 0.22 ethambutol
embA 4246329 p.Thr1033Ala missense_variant 0.18 ethambutol
embB 4247395 c.882C>G synonymous_variant 0.21 ethambutol
embB 4247401 c.888T>C synonymous_variant 0.24 ethambutol
embB 4247407 c.894G>C synonymous_variant 0.23 ethambutol
embB 4247425 c.912G>C synonymous_variant 0.23 ethambutol
embB 4247434 c.921C>G synonymous_variant 0.23 ethambutol
embB 4247437 c.924A>G synonymous_variant 0.26 ethambutol Not assoc w R - Interim
embB 4247440 c.927C>G synonymous_variant 0.26 ethambutol
embB 4247446 c.933C>T synonymous_variant 0.25 ethambutol
embB 4247464 c.951C>G synonymous_variant 0.31 ethambutol
embB 4247470 c.957T>C synonymous_variant 0.32 ethambutol
embB 4247491 c.978G>C synonymous_variant 0.33 ethambutol
embB 4247497 c.984T>C synonymous_variant 0.33 ethambutol
embB 4247512 c.999T>C synonymous_variant 0.31 ethambutol
embB 4247539 c.1026T>C synonymous_variant 0.22 ethambutol
embB 4247554 c.1041T>C synonymous_variant 0.19 ethambutol
embB 4247566 c.1053C>A synonymous_variant 0.18 ethambutol
embB 4247572 c.1059A>G synonymous_variant 0.19 ethambutol
embB 4247579 p.Ala356Phe missense_variant 0.19 ethambutol
embB 4247587 c.1074G>A synonymous_variant 0.18 ethambutol
embB 4247603 c.1090C>T synonymous_variant 0.17 ethambutol
embB 4247773 c.1260G>A synonymous_variant 0.2 ethambutol
embB 4247776 c.1263G>T synonymous_variant 0.22 ethambutol
embB 4247797 c.1284C>G synonymous_variant 0.27 ethambutol
embB 4247800 c.1287A>T synonymous_variant 0.27 ethambutol
embB 4247803 c.1290G>C synonymous_variant 0.31 ethambutol
embB 4247815 c.1302C>G synonymous_variant 0.3 ethambutol
embB 4247819 p.Val436Ile missense_variant 0.3 ethambutol Uncertain significance
embB 4247830 c.1317A>G synonymous_variant 0.27 ethambutol Not assoc w R - Interim
embB 4247836 c.1323A>G synonymous_variant 0.3 ethambutol Not assoc w R - Interim
embB 4247839 c.1326G>C synonymous_variant 0.32 ethambutol Not assoc w R - Interim
embB 4247866 c.1353G>C synonymous_variant 0.34 ethambutol
embB 4247875 c.1362G>C synonymous_variant 0.31 ethambutol
embB 4247876 c.1363C>T synonymous_variant 0.32 ethambutol
embB 4247881 c.1368G>C synonymous_variant 0.32 ethambutol
embB 4247887 c.1374C>T synonymous_variant 0.33 ethambutol Not assoc w R - Interim
embB 4247893 c.1380C>T synonymous_variant 0.34 ethambutol
embB 4247899 p.Met462Ile missense_variant 0.31 ethambutol
embB 4247905 c.1392G>C synonymous_variant 0.31 ethambutol Not assoc w R - Interim
embB 4247909 c.1396T>C synonymous_variant 0.3 ethambutol
embB 4247914 c.1401G>C synonymous_variant 0.29 ethambutol Not assoc w R - Interim
embB 4247932 c.1419C>G synonymous_variant 0.28 ethambutol
embB 4247940 p.Leu476Trp missense_variant 0.27 ethambutol
embB 4247945 c.1432T>C synonymous_variant 0.26 ethambutol
embB 4247951 p.Ser480Ala missense_variant 0.27 ethambutol
embB 4247956 c.1443G>C synonymous_variant 0.2 ethambutol Not assoc w R - Interim
embB 4248007 c.1494C>G synonymous_variant 0.19 ethambutol
embB 4248011 p.Ser500Arg missense_variant 0.17 ethambutol
embB 4248014 p.Thr501Ala missense_variant 0.17 ethambutol Uncertain significance
embB 4248035 p.Val508Ile missense_variant 0.18 ethambutol
embB 4248040 c.1527C>G synonymous_variant 0.17 ethambutol
embB 4248041 p.Ala510Thr missense_variant 0.17 ethambutol Uncertain significance
embB 4248044 p.Lys511Ala missense_variant 0.18 ethambutol
embB 4248070 c.1557T>C synonymous_variant 0.16 ethambutol
embB 4248157 c.1644A>G synonymous_variant 0.14 ethambutol Not assoc w R - Interim
embB 4248220 c.1707A>C synonymous_variant 0.16 ethambutol
embB 4248304 c.1791G>C synonymous_variant 0.19 ethambutol
embB 4248316 c.1803C>G synonymous_variant 0.21 ethambutol
embB 4248319 c.1806A>G synonymous_variant 0.21 ethambutol
embB 4249408 c.2895G>A synonymous_variant 0.94 ethambutol Not assoc w R
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 kanamycin
capreomycin
amikacin