TB-Profiler result

Run: ERR11465802
Summary

Run ID: ERR11465802

Sample name:

Date: 2024-03-25T22:30:25.759628

Number of reads: 6026622

Percentage reads mapped: 98.21

Median coverage: 120.0

Strain: La1.7;lineage4.3.4.1

Spoligotype:

Drug-resistance: Other

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage4.3 Euro-American (LAM) None 0.98
La1.7 M.bovis None 0.09
lineage4.3.4.1 Euro-American (LAM) RD174 0.99
lineage4 Euro-American None 1.0
lineage4.3.4 Euro-American (LAM) RD174 1.0
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol
pyrazinamide
streptomycin rrs n.462C>T Uncertain significance Mutation from literature
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid fbiC c.916_918delTTCinsGG Assoc w R - Interim Confers DLM-PMD cross-resistance
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
fbiC 1303846 c.916_918delTTCinsGG frameshift_variant&missense_variant 0.17 pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
rrs 1472307 n.462C>T non_coding_transcript_exon_variant 0.21 streptomycin Uncertain significance Mutation from literature
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
gyrA 7165 c.-137C>T upstream_gene_variant 0.18 levofloxacin
moxifloxacin
gyrA 7168 c.-134C>G upstream_gene_variant 0.17 levofloxacin
moxifloxacin
gyrA 7178 c.-124T>C upstream_gene_variant 0.15 levofloxacin
moxifloxacin
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7832 c.531G>T synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 7835 c.534A>G synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7847 c.546G>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 7853 c.552C>T synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7859 c.558A>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 7886 c.585T>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 7892 c.591G>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 7898 p.Asp199Glu missense_variant 0.18 levofloxacin
moxifloxacin
gyrA 7913 c.612G>C synonymous_variant 0.13 levofloxacin
moxifloxacin
gyrA 7942 p.Glu214Ala missense_variant 0.14 levofloxacin
moxifloxacin
gyrA 7946 c.645C>G synonymous_variant 0.14 levofloxacin
moxifloxacin
gyrA 8603 c.1302A>G synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8627 c.1326C>T synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8642 c.1341A>G synonymous_variant 0.14 levofloxacin
moxifloxacin
gyrA 8645 c.1344C>T synonymous_variant 0.14 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8648 c.1347G>A synonymous_variant 0.14 levofloxacin
moxifloxacin
gyrA 8655 p.Ile452Val missense_variant 0.16 levofloxacin
moxifloxacin
gyrA 8672 c.1371A>G synonymous_variant 0.14 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8915 c.1614A>G synonymous_variant 0.14 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8918 c.1617C>G synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 8996 c.1695T>C synonymous_variant 0.14 levofloxacin
moxifloxacin
gyrA 9089 c.1788G>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 9092 c.1791C>G synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 9099 c.1798_1800delTTAinsCG frameshift_variant&missense_variant 0.18 levofloxacin
moxifloxacin
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
Rv0010c 13483 p.Ala26Thr missense_variant 1.0 isoniazid Uncertain significance
fgd1 491217 c.435T>G synonymous_variant 0.14 clofazimine
pretomanid
delamanid
fgd1 491232 c.450T>C synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fgd1 491241 p.Asp153Glu missense_variant 0.21 clofazimine
pretomanid
delamanid
fgd1 491244 c.462T>C synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fgd1 491259 c.477T>C synonymous_variant 0.16 clofazimine
pretomanid
delamanid
mshA 575686 c.339G>C synonymous_variant 0.13 ethionamide
isoniazid
mshA 575704 c.357T>C synonymous_variant 0.14 ethionamide
isoniazid
mshA 575705 c.358T>C synonymous_variant 0.15 ethionamide
isoniazid
mshA 575719 c.372C>T synonymous_variant 0.17 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
mshA 575720 c.373C>T synonymous_variant 0.17 ethionamide
isoniazid
mshA 575725 c.378C>G synonymous_variant 0.17 ethionamide
isoniazid
mshA 575806 c.459G>C synonymous_variant 0.2 ethionamide
isoniazid
mshA 575809 c.462C>T synonymous_variant 0.2 ethionamide
isoniazid
mshA 575816 c.469C>T synonymous_variant 0.19 ethionamide
isoniazid
mshA 575821 c.474G>C synonymous_variant 0.19 ethionamide
isoniazid
mshA 575839 c.492G>C synonymous_variant 0.15 ethionamide
isoniazid
mshA 575842 c.495G>C synonymous_variant 0.15 ethionamide
isoniazid
mshA 575845 c.498C>A synonymous_variant 0.16 ethionamide
isoniazid
mshA 575851 c.504C>T synonymous_variant 0.2 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
mshA 575872 c.525C>T synonymous_variant 0.2 ethionamide
isoniazid
mshA 575878 c.531A>G synonymous_variant 0.16 ethionamide
isoniazid
mshA 575893 c.546C>G synonymous_variant 0.15 ethionamide
isoniazid
mshA 575905 c.558G>C synonymous_variant 0.15 ethionamide
isoniazid
mshA 575908 c.561A>G synonymous_variant 0.15 ethionamide
isoniazid
mshA 575916 p.Asp190Ala missense_variant 0.14 ethionamide
isoniazid
mshA 575924 p.Gly193Ile missense_variant 0.14 ethionamide
isoniazid
mshA 576190 c.843C>T synonymous_variant 0.15 ethionamide Not assoc w R - Interim
isoniazid
mshA 576193 c.846T>C synonymous_variant 0.15 ethionamide
isoniazid
hadA 731789 c.-141A>G upstream_gene_variant 0.15 isoniazid
hadA 731852 c.-78A>G upstream_gene_variant 0.15 isoniazid
nusG 734451 c.198G>C synonymous_variant 0.14 rifampicin
nusG 734460 c.207G>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
nusG 734532 c.279A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
nusG 734589 c.336G>C synonymous_variant 0.13 rifampicin
rpoB 760235 c.429T>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 760298 c.492G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760358 c.552C>G synonymous_variant 0.17 rifampicin
rpoB 760361 c.555T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760376 p.Asp190Glu missense_variant 0.16 rifampicin Uncertain significance
rpoB 760406 c.600G>C synonymous_variant 0.14 rifampicin
rpoB 760424 c.618C>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760451 c.645C>G synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 760646 c.840C>G synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 760655 c.849A>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 760661 c.855A>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760670 c.864G>C synonymous_variant 0.19 rifampicin
rpoB 760674 c.868T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760679 c.873A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760683 c.877T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760718 c.912C>T synonymous_variant 0.18 rifampicin
rpoB 760724 c.918T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 760730 c.924T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 760748 c.942C>G synonymous_variant 0.14 rifampicin
rpoB 760751 c.945G>C synonymous_variant 0.14 rifampicin
rpoB 760796 c.990A>G synonymous_variant 0.15 rifampicin
rpoB 760830 c.1024_1026delTTGinsCC frameshift_variant&missense_variant 0.15 rifampicin
rpoB 760919 c.1113C>G synonymous_variant 0.14 rifampicin
rpoB 760925 c.1119T>C synonymous_variant 0.15 rifampicin
rpoB 760928 c.1122G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 760931 c.1125C>G synonymous_variant 0.16 rifampicin
rpoB 760946 c.1140A>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 761132 c.1326G>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 761133 c.1327T>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 761510 c.1704T>C synonymous_variant 0.27 rifampicin
rpoB 761537 c.1731C>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 761573 c.1767C>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 761579 c.1773G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 761582 c.1776G>A synonymous_variant 0.22 rifampicin
rpoB 761606 c.1800C>G synonymous_variant 0.25 rifampicin
rpoB 761612 c.1806G>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 761615 c.1809A>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 761645 c.1839C>G synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 762101 c.2295C>G synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoB 762813 p.Met1003Val missense_variant 0.14 rifampicin
rpoB 762818 c.3012C>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 762857 c.3051C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 762929 c.3123G>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 762956 c.-414G>C upstream_gene_variant 0.17 rifampicin
rpoB 762959 c.3153G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 762983 c.-387C>G upstream_gene_variant 0.14 rifampicin
rpoC 763483 c.114G>C synonymous_variant 0.15 rifampicin
rpoC 763486 c.117T>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 763492 c.123G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 763594 c.225C>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 763603 c.234C>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 763615 c.246G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 763618 c.249C>T synonymous_variant 0.28 rifampicin
rpoC 763624 c.255C>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 763648 c.279C>G synonymous_variant 0.23 rifampicin
rpoC 763660 c.291T>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 763666 c.297G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 763669 c.300C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 763696 c.327T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 763699 c.330G>C synonymous_variant 0.17 rifampicin
rpoC 763702 c.333C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 763709 c.340C>T synonymous_variant 0.19 rifampicin
rpoC 763714 c.345G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 763717 c.348T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 763732 c.363C>G synonymous_variant 0.25 rifampicin
rpoC 763735 c.366G>C synonymous_variant 0.26 rifampicin
rpoC 763765 c.396T>C synonymous_variant 0.23 rifampicin
rpoC 763768 c.399C>G synonymous_variant 0.23 rifampicin
rpoC 763781 p.Ser138Ala missense_variant 0.2 rifampicin
rpoC 763792 p.Glu141Asp missense_variant 0.22 rifampicin
rpoC 763807 c.438T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 763816 c.447C>G synonymous_variant 0.23 rifampicin
rpoC 763822 c.453C>G synonymous_variant 0.23 rifampicin
rpoC 763825 c.456G>A synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 763828 c.459C>G synonymous_variant 0.24 rifampicin
rpoC 763836 p.Ala156Val missense_variant 0.23 rifampicin
rpoC 763858 c.489A>G synonymous_variant 0.26 rifampicin
rpoC 763872 p.Gly168Ala missense_variant 0.24 rifampicin
rpoC 763876 p.Glu169Asp missense_variant 0.23 rifampicin
rpoC 763879 c.510A>G synonymous_variant 0.24 rifampicin
rpoC 763888 c.519G>C synonymous_variant 0.19 rifampicin
rpoC 763891 c.522G>C synonymous_variant 0.18 rifampicin
rpoC 763894 c.525A>G synonymous_variant 0.18 rifampicin
rpoC 763900 c.531G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 763945 c.576T>C synonymous_variant 0.14 rifampicin
rpoC 763948 c.579G>C synonymous_variant 0.14 rifampicin
rpoC 763949 c.580C>A synonymous_variant 0.14 rifampicin
rpoC 763960 c.591T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764227 c.858G>C synonymous_variant 0.17 rifampicin
rpoC 764266 c.897T>C synonymous_variant 0.15 rifampicin
rpoC 764548 c.1179G>A synonymous_variant 0.15 rifampicin
rpoC 764803 c.1434C>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 764809 c.1440C>T synonymous_variant 0.14 rifampicin Not assoc w R
rpoC 764812 c.1443C>G synonymous_variant 0.14 rifampicin
rpoC 764824 c.1455T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 764833 c.1464A>G synonymous_variant 0.16 rifampicin
rpoC 764836 c.1467G>A synonymous_variant 0.17 rifampicin
rpoC 764842 c.1473C>T synonymous_variant 0.18 rifampicin
rpoC 764858 c.1489T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 764869 c.1500C>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764875 c.1506C>G synonymous_variant 0.17 rifampicin
rpoC 764893 c.1524T>C synonymous_variant 0.2 rifampicin
rpoC 764896 c.1527C>T synonymous_variant 0.19 rifampicin
rpoC 764911 c.1542A>G synonymous_variant 0.19 rifampicin
rpoC 764968 c.1599T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764995 c.1626C>G synonymous_variant 0.82 rifampicin Not assoc w R
rpoC 765478 c.2109T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 765499 c.2130C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 765508 c.2139C>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 766297 c.2928G>C synonymous_variant 0.14 rifampicin
rpoC 766381 c.3012C>T synonymous_variant 0.16 rifampicin
rpoC 766384 c.3015A>G synonymous_variant 0.16 rifampicin
rpoC 766393 c.3024C>G synonymous_variant 0.22 rifampicin
rpoC 766408 c.3039C>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 766426 c.3057C>T synonymous_variant 0.16 rifampicin
rpoC 766429 c.3060C>G synonymous_variant 0.16 rifampicin
rpoC 766435 c.3066G>A synonymous_variant 0.16 rifampicin
rpoC 766447 c.3078T>C synonymous_variant 0.17 rifampicin
rpoC 766459 c.3090G>T synonymous_variant 0.15 rifampicin
rpoC 766462 c.3093G>C synonymous_variant 0.16 rifampicin
rpoC 766549 c.3180G>C synonymous_variant 0.14 rifampicin
rpoC 766558 c.3189G>A synonymous_variant 0.19 rifampicin
rpoC 766564 c.3195C>T synonymous_variant 0.15 rifampicin
rpoC 766565 p.Ile1066Val missense_variant 0.15 rifampicin Uncertain significance
rpoC 766573 c.3204T>C synonymous_variant 0.13 rifampicin
rpoC 766585 c.3216T>C synonymous_variant 0.18 rifampicin
rpoC 766607 c.3238_3240delATCinsCG frameshift_variant&missense_variant 0.18 rifampicin
rpoC 766618 c.3249G>T synonymous_variant 0.21 rifampicin
rpoC 766624 c.3255G>C synonymous_variant 0.22 rifampicin
rpoC 766645 c.3276A>G synonymous_variant 0.27 rifampicin
rpoC 766657 c.3288A>G synonymous_variant 0.25 rifampicin
rpoC 766667 p.Ser1100Ala missense_variant 0.24 rifampicin Uncertain significance
rpoC 766672 c.3303T>C synonymous_variant 0.22 rifampicin
rpoC 766726 c.3357T>C synonymous_variant 0.18 rifampicin
rpoC 766738 c.3369G>C synonymous_variant 0.18 rifampicin
rpoC 766750 c.3381C>G synonymous_variant 0.18 rifampicin
rpoC 766753 c.3384C>T synonymous_variant 0.17 rifampicin
rpoC 766765 c.3396A>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 766774 c.3405T>C synonymous_variant 0.21 rifampicin
rpoC 766798 c.3429C>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 766804 c.3435A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 766843 c.3474T>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 766861 c.3492G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 766864 c.3495G>C synonymous_variant 0.19 rifampicin
rpoC 766918 c.3549C>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 766933 c.3564A>G synonymous_variant 0.15 rifampicin
rpoC 766945 c.3576A>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 766960 c.3591C>T synonymous_variant 0.2 rifampicin
rpoC 766963 c.3594T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 766972 c.3603G>C synonymous_variant 0.19 rifampicin
rpoC 766996 c.3627C>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 767033 c.3664_3666delTCGinsAGT synonymous_variant 0.2 rifampicin
rpoC 767059 c.3690T>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 767062 c.3693C>A synonymous_variant 0.19 rifampicin
rpoC 767098 c.3729T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 767119 c.3750A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 767134 c.3765C>A synonymous_variant 0.18 rifampicin
rpoC 767152 c.3783T>G synonymous_variant 0.15 rifampicin
rpoC 767155 c.3786C>G synonymous_variant 0.15 rifampicin
mmpL5 775639 p.Ile948Val missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781655 c.96T>C synonymous_variant 0.14 streptomycin
rpsL 781658 c.99A>G synonymous_variant 0.15 streptomycin
rpsL 781832 c.273T>C synonymous_variant 0.14 streptomycin
rpsL 781865 c.306G>C synonymous_variant 0.15 streptomycin
rpsL 781868 c.309T>C synonymous_variant 0.15 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.14 streptomycin
rplC 800516 c.-293G>C upstream_gene_variant 0.16 linezolid
fbiC 1303536 c.606G>C synonymous_variant 0.15 clofazimine
pretomanid
delamanid
fbiC 1303545 c.615A>G synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1303584 c.654C>G synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1303590 c.660A>G synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1303614 c.684C>G synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1303623 c.693C>T synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1303632 c.702T>G synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1303641 c.711C>T synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1303650 c.720G>C synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1303654 c.724C>T synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1303661 p.Val244Ala missense_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1303695 c.765T>C synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1303701 c.771C>T synonymous_variant 0.19 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1303704 c.774T>G synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1303713 c.783C>G synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1303731 c.801A>G synonymous_variant 0.14 clofazimine
pretomanid
delamanid
fbiC 1303732 p.Ser268Ala missense_variant 0.14 clofazimine
pretomanid
delamanid
fbiC 1303740 c.810C>G synonymous_variant 0.14 clofazimine
pretomanid
delamanid
fbiC 1303746 c.816T>C synonymous_variant 0.13 clofazimine
pretomanid
delamanid
fbiC 1303818 c.888C>G synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1303844 p.Ala305Asp missense_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1303851 c.921C>T synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1303860 c.930A>C synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1303872 c.942C>T synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1303884 c.954T>G synonymous_variant 0.14 clofazimine
pretomanid
delamanid
fbiC 1303893 c.963G>C synonymous_variant 0.13 clofazimine
pretomanid
delamanid
fbiC 1303905 c.975G>C synonymous_variant 0.15 clofazimine
pretomanid
delamanid
fbiC 1303908 c.978C>A synonymous_variant 0.14 clofazimine
pretomanid
delamanid
fbiC 1303911 c.981G>C synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1304799 c.1869G>C synonymous_variant 0.14 clofazimine
pretomanid
delamanid
fbiC 1304811 c.1881C>G synonymous_variant 0.15 clofazimine
pretomanid
delamanid
sigE 1364434 p.Arg8Trp missense_variant 1.0 pyrazinamide Not assoc w R
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472225 n.380C>A non_coding_transcript_exon_variant 0.22 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Uncertain significance
rrs 1472314 n.469A>G non_coding_transcript_exon_variant 0.17 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472315 n.470T>C non_coding_transcript_exon_variant 0.17 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472489 n.644A>T non_coding_transcript_exon_variant 0.28 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472969 n.1124A>G non_coding_transcript_exon_variant 0.13 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472970 n.1125C>G non_coding_transcript_exon_variant 0.13 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472977 n.1132G>C non_coding_transcript_exon_variant 0.13 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472978 n.1133T>C non_coding_transcript_exon_variant 0.16 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrl 1474181 n.524C>T non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid
rrl 1474266 n.609T>C non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474362 n.705A>G non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474639 n.982G>A non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474716 n.1059A>C non_coding_transcript_exon_variant 0.31 capreomycin
linezolid
rrl 1474794 n.1137C>A non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474831 n.1174A>G non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid
rrl 1475429 n.1772G>A non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475443 n.1786G>A non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475479 n.1822C>T non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475480 n.1823A>T non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475505 n.1848G>A non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475573 n.1916G>A non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid
rrl 1475599 n.1942A>G non_coding_transcript_exon_variant 0.16 capreomycin
linezolid Uncertain significance
rrl 1475604 n.1947A>C non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid
rrl 1475606 n.1949T>C non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid
rrl 1475760 n.2103C>T non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1475763 n.2106C>T non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid
rrl 1476214 n.2557G>T non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476215 n.2558C>T non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476297 n.2640C>T non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476299 n.2642C>T non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476580 n.2923G>A non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1476597 n.2940G>A non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid
rrl 1476608 n.2951C>T non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476619 n.2962C>T non_coding_transcript_exon_variant 0.16 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid Uncertain significance
rpsA 1833661 c.120A>G synonymous_variant 0.15 pyrazinamide
rpsA 1833664 c.123C>A synonymous_variant 0.16 pyrazinamide
rpsA 1833724 c.183C>G synonymous_variant 0.21 pyrazinamide
rpsA 1833727 c.186G>C synonymous_variant 0.21 pyrazinamide
rpsA 1833742 c.201A>G synonymous_variant 0.16 pyrazinamide
rpsA 1833745 c.204G>C synonymous_variant 0.17 pyrazinamide
rpsA 1833802 c.261A>G synonymous_variant 0.25 pyrazinamide
rpsA 1833811 c.270G>T synonymous_variant 0.28 pyrazinamide
rpsA 1833820 c.279G>A synonymous_variant 0.3 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.26 pyrazinamide
rpsA 1833859 c.318C>T synonymous_variant 0.27 pyrazinamide
rpsA 1833874 c.333T>C synonymous_variant 0.25 pyrazinamide
rpsA 1833894 p.Ala118Glu missense_variant 0.25 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.2 pyrazinamide
rpsA 1833940 c.399C>G synonymous_variant 0.26 pyrazinamide
rpsA 1833970 c.429G>C synonymous_variant 0.2 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.2 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.22 pyrazinamide
rpsA 1834012 c.471G>C synonymous_variant 0.15 pyrazinamide
rpsA 1834018 c.477C>T synonymous_variant 0.22 pyrazinamide
rpsA 1834021 c.480C>T synonymous_variant 0.23 pyrazinamide
rpsA 1834030 c.489C>G synonymous_variant 0.24 pyrazinamide
rpsA 1834042 c.501G>A synonymous_variant 0.18 pyrazinamide
rpsA 1834051 c.510G>A synonymous_variant 0.18 pyrazinamide
rpsA 1834093 c.552G>C synonymous_variant 0.13 pyrazinamide
rpsA 1834099 c.558C>G synonymous_variant 0.14 pyrazinamide
rpsA 1834177 c.636A>C synonymous_variant 0.14 pyrazinamide Not assoc w R - Interim
rpsA 1834195 c.654G>C synonymous_variant 0.15 pyrazinamide
rpsA 1834240 c.699T>C synonymous_variant 0.13 pyrazinamide
rpsA 1834297 c.756C>G synonymous_variant 0.17 pyrazinamide
rpsA 1834303 c.762T>G synonymous_variant 0.16 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.16 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 0.15 pyrazinamide Not assoc w R - Interim
rpsA 1834366 c.825A>G synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
rpsA 1834369 c.828C>G synonymous_variant 0.17 pyrazinamide
rpsA 1834396 c.855G>C synonymous_variant 0.17 pyrazinamide
rpsA 1834411 c.870T>C synonymous_variant 0.18 pyrazinamide
rpsA 1834451 c.910T>C synonymous_variant 0.17 pyrazinamide
rpsA 1834456 c.915T>G synonymous_variant 0.17 pyrazinamide
rpsA 1834459 c.918G>C synonymous_variant 0.17 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.17 pyrazinamide
rpsA 1834489 c.948T>C synonymous_variant 0.14 pyrazinamide
rpsA 1834499 c.958C>T synonymous_variant 0.16 pyrazinamide
rpsA 1834507 c.966C>T synonymous_variant 0.17 pyrazinamide
rpsA 1834534 c.993C>G synonymous_variant 0.15 pyrazinamide
rpsA 1834555 c.1014T>C synonymous_variant 0.14 pyrazinamide
tsnR 1853429 c.-177G>C upstream_gene_variant 0.13 linezolid
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
katG 2154846 c.1266C>A synonymous_variant 0.23 isoniazid
Rv1979c 2222854 p.Ile104Thr missense_variant 1.0 clofazimine Uncertain significance
bedaquiline Uncertain significance
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
kasA 2518747 c.633C>G synonymous_variant 0.17 isoniazid
kasA 2518765 c.651G>A synonymous_variant 0.18 isoniazid
kasA 2518768 c.654C>G synonymous_variant 0.18 isoniazid
kasA 2518783 c.669T>C synonymous_variant 0.19 isoniazid
kasA 2518792 c.678C>G synonymous_variant 0.23 isoniazid
kasA 2518795 c.681C>G synonymous_variant 0.26 isoniazid
kasA 2518816 c.702C>G synonymous_variant 0.19 isoniazid
kasA 2518822 c.708C>G synonymous_variant 0.17 isoniazid
kasA 2518825 c.711T>C synonymous_variant 0.17 isoniazid
kasA 2518843 c.729T>G synonymous_variant 0.17 isoniazid
kasA 2518846 c.732G>A synonymous_variant 0.17 isoniazid
kasA 2518847 p.Leu245Met missense_variant 0.17 isoniazid
kasA 2518853 p.Leu247Ile missense_variant 0.17 isoniazid
kasA 2518864 c.750G>C synonymous_variant 0.21 isoniazid
kasA 2518879 c.765A>G synonymous_variant 0.16 isoniazid
folC 2747059 c.538_540delCGTinsAC frameshift_variant&missense_variant 0.16 para-aminosalicylic_acid
folC 2747062 c.537A>C synonymous_variant 0.16 para-aminosalicylic_acid
folC 2747065 c.534C>T synonymous_variant 0.16 para-aminosalicylic_acid
folC 2747086 c.513A>G synonymous_variant 0.13 para-aminosalicylic_acid
Rv2477c 2783440 c.603T>C synonymous_variant 0.14 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
pepQ 2859450 c.969C>G synonymous_variant 0.17 clofazimine
bedaquiline
Rv2752c 3065463 c.729T>C synonymous_variant 0.13 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
thyA 3073868 p.Thr202Ala missense_variant 0.94 para-aminosalicylic_acid
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
Rv3236c 3612009 p.Ala370Thr missense_variant 1.0 pyrazinamide Not assoc w R
mtrB 3625065 p.Met517Leu missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
lpqB 3625537 c.-627T>C upstream_gene_variant 0.14 bedaquiline
rifampicin
lpqB 3625543 c.-633G>C upstream_gene_variant 0.15 bedaquiline
rifampicin
mtrB 3625569 c.1045T>C synonymous_variant 0.14 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625579 c.-669A>C upstream_gene_variant 0.14 bedaquiline
rifampicin
mtrB 3625592 p.Ser341Asn missense_variant 0.14 bedaquiline
rifampicin
lpqB 3625594 c.-684T>C upstream_gene_variant 0.14 bedaquiline
rifampicin
lpqB 3625602 c.-692T>C upstream_gene_variant 0.14 bedaquiline
rifampicin
lpqB 3625612 c.-702G>C upstream_gene_variant 0.14 bedaquiline
rifampicin
mtrB 3625623 p.Thr331Ala missense_variant 0.13 bedaquiline
rifampicin
lpqB 3625627 c.-717C>T upstream_gene_variant 0.14 bedaquiline
rifampicin
lpqB 3625630 c.-720C>G upstream_gene_variant 0.14 bedaquiline
rifampicin
mtrB 3625638 p.Ala326Ser missense_variant 0.16 bedaquiline
rifampicin
lpqB 3625648 c.-738T>C upstream_gene_variant 0.17 bedaquiline
rifampicin
mtrB 3625656 c.958T>C synonymous_variant 0.17 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
lpqB 3625663 c.-753G>C upstream_gene_variant 0.16 bedaquiline
rifampicin
mtrB 3625720 c.894G>C synonymous_variant 0.16 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625723 c.-813C>T upstream_gene_variant 0.16 bedaquiline
rifampicin
lpqB 3625731 c.-821C>T upstream_gene_variant 0.16 bedaquiline
rifampicin
mtrB 3625744 c.870G>A synonymous_variant 0.2 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625747 c.867G>C synonymous_variant 0.2 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625753 c.859_861delGCCinsAT frameshift_variant&missense_variant 0.21 bedaquiline Uncertain significance
rifampicin Uncertain significance
mtrB 3625765 c.849C>G synonymous_variant 0.23 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625774 c.840G>A synonymous_variant 0.28 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625806 c.808A>C synonymous_variant 0.26 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625807 c.807C>G synonymous_variant 0.26 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625828 c.-918G>C upstream_gene_variant 0.25 bedaquiline
rifampicin
mtrB 3625852 c.762A>G synonymous_variant 0.28 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625867 c.747A>G synonymous_variant 0.28 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625912 c.702G>C synonymous_variant 0.34 bedaquiline
rifampicin
mtrB 3625915 c.699G>T synonymous_variant 0.34 bedaquiline
rifampicin
mtrB 3625927 c.687T>C synonymous_variant 0.27 bedaquiline
rifampicin
mtrB 3625936 c.678C>G synonymous_variant 0.22 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625942 c.670_672delGTCinsCT frameshift_variant&missense_variant 0.18 bedaquiline Uncertain significance
rifampicin Uncertain significance
mtrB 3625945 c.669A>G synonymous_variant 0.18 bedaquiline
rifampicin
mtrB 3625950 c.664C>T synonymous_variant 0.19 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625951 c.663A>G synonymous_variant 0.18 bedaquiline
rifampicin
mtrB 3625956 c.658C>T synonymous_variant 0.21 bedaquiline
rifampicin
mtrB 3626266 c.348C>T synonymous_variant 0.13 bedaquiline
rifampicin
mtrB 3626284 c.330T>C synonymous_variant 0.15 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626296 c.318T>G synonymous_variant 0.17 bedaquiline
rifampicin
mtrB 3626308 c.306T>C synonymous_variant 0.18 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626329 c.285G>A synonymous_variant 0.26 bedaquiline
rifampicin
mtrB 3626344 c.270G>A synonymous_variant 0.24 bedaquiline
rifampicin
mtrB 3626357 p.Thr86Gly missense_variant 0.18 bedaquiline
rifampicin
mtrB 3626362 c.252A>G synonymous_variant 0.17 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626377 c.237C>T synonymous_variant 0.2 bedaquiline
rifampicin
mtrB 3626381 p.Ile78Thr missense_variant 0.2 bedaquiline
rifampicin
mtrB 3626390 p.Arg75Lys missense_variant 0.18 bedaquiline
rifampicin
mtrB 3626398 c.214_216delATCinsGG frameshift_variant&missense_variant 0.24 bedaquiline Uncertain significance
rifampicin Uncertain significance
mtrB 3626410 c.204T>C synonymous_variant 0.23 bedaquiline
rifampicin
mtrB 3626705 c.-92G>T upstream_gene_variant 0.15 bedaquiline
rifampicin
mtrB 3626711 c.-98T>C upstream_gene_variant 0.14 bedaquiline
rifampicin
mtrA 3626741 c.609C>G synonymous_variant 0.25 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626744 c.-131G>C upstream_gene_variant 0.25 bedaquiline
rifampicin
mtrB 3626750 c.-137T>C upstream_gene_variant 0.24 bedaquiline
rifampicin
mtrA 3626759 c.591T>C synonymous_variant 0.21 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3626774 c.574_576delAGGinsCC frameshift_variant&missense_variant 0.18 bedaquiline
rifampicin
mtrB 3626780 c.-167T>C upstream_gene_variant 0.18 bedaquiline
rifampicin
mtrB 3626783 c.-170C>G upstream_gene_variant 0.19 bedaquiline
rifampicin
mtrA 3626786 c.564A>G synonymous_variant 0.19 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626798 c.-185T>A upstream_gene_variant 0.24 bedaquiline
rifampicin
mtrB 3626804 c.-191A>C upstream_gene_variant 0.24 bedaquiline
rifampicin
mtrB 3626866 c.-253T>C upstream_gene_variant 0.15 bedaquiline
rifampicin
mtrB 3626876 c.-263A>G upstream_gene_variant 0.15 bedaquiline
rifampicin
mtrB 3626885 c.-272A>G upstream_gene_variant 0.17 bedaquiline
rifampicin
mtrB 3626890 c.-277T>C upstream_gene_variant 0.17 bedaquiline
rifampicin
mtrB 3626891 c.-278G>C upstream_gene_variant 0.17 bedaquiline
rifampicin
mtrB 3626930 c.-317A>G upstream_gene_variant 0.19 bedaquiline
rifampicin
mtrA 3626939 p.Glu137Asp missense_variant 0.2 bedaquiline
rifampicin
mtrB 3626942 c.-329A>C upstream_gene_variant 0.21 bedaquiline
rifampicin
mtrB 3626954 c.-341C>G upstream_gene_variant 0.15 bedaquiline
rifampicin
mtrB 3626969 c.-356C>G upstream_gene_variant 0.2 bedaquiline
rifampicin
mtrB 3626972 c.-359A>G upstream_gene_variant 0.2 bedaquiline
rifampicin
mtrB 3627008 c.-395G>C upstream_gene_variant 0.2 bedaquiline
rifampicin
mtrB 3627011 c.-398T>G upstream_gene_variant 0.2 bedaquiline
rifampicin
mtrB 3627059 c.-446G>C upstream_gene_variant 0.22 bedaquiline
rifampicin
mtrA 3627068 c.282T>C synonymous_variant 0.21 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627071 c.-458G>C upstream_gene_variant 0.22 bedaquiline
rifampicin
mtrA 3627080 c.270T>C synonymous_variant 0.24 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3627098 c.252A>C synonymous_variant 0.14 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627104 c.-491C>G upstream_gene_variant 0.14 bedaquiline
rifampicin
mtrB 3627317 c.-704T>C upstream_gene_variant 0.14 bedaquiline
rifampicin
rpoA 3877533 c.975C>G synonymous_variant 0.14 rifampicin
rpoA 3877557 c.951C>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoA 3877569 c.939G>C synonymous_variant 0.16 rifampicin
rpoA 3877587 c.921A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoA 3877593 c.915C>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3877596 c.912G>C synonymous_variant 0.19 rifampicin
rpoA 3877613 p.Ile299Val missense_variant 0.23 rifampicin
rpoA 3877737 c.771G>C synonymous_variant 0.17 rifampicin
rpoA 3877743 c.765T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoA 3877818 c.690A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3877839 c.669G>T synonymous_variant 0.2 rifampicin
rpoA 3877848 c.660C>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3877857 c.651G>A synonymous_variant 0.2 rifampicin
rpoA 3877872 c.636C>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3877875 c.633T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3877881 c.627G>C synonymous_variant 0.18 rifampicin
rpoA 3877893 c.615C>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3877900 p.Ser203Thr missense_variant 0.15 rifampicin
rpoA 3877905 c.603A>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoA 3877908 p.Asn200Ser missense_variant 0.15 rifampicin
rpoA 3878247 c.261G>C synonymous_variant 0.2 rifampicin
rpoA 3878253 c.255G>C synonymous_variant 0.15 rifampicin
rpoA 3879022 c.-515G>C upstream_gene_variant 0.15 rifampicin
clpC1 4038287 c.2418C>T synonymous_variant 0.92 pyrazinamide Not assoc w R
clpC1 4038368 c.2337T>G synonymous_variant 0.16 pyrazinamide
clpC1 4038388 c.2317T>C synonymous_variant 0.15 pyrazinamide
clpC1 4038392 c.2313C>T synonymous_variant 0.16 pyrazinamide
clpC1 4038398 c.2307G>T synonymous_variant 0.15 pyrazinamide
clpC1 4038403 c.2302T>C synonymous_variant 0.15 pyrazinamide Not assoc w R - Interim
clpC1 4038487 p.Gly740Ser missense_variant 0.14 pyrazinamide
clpC1 4038569 c.2136C>T synonymous_variant 0.22 pyrazinamide
clpC1 4038596 c.2109A>G synonymous_variant 0.15 pyrazinamide
clpC1 4039952 c.753T>C synonymous_variant 0.15 pyrazinamide
clpC1 4039958 c.747G>C synonymous_variant 0.14 pyrazinamide
clpC1 4039991 c.714G>A synonymous_variant 0.89 pyrazinamide Not assoc w R
clpC1 4040654 c.51G>A synonymous_variant 0.19 pyrazinamide
clpC1 4040657 c.48T>G synonymous_variant 0.18 pyrazinamide Not assoc w R - Interim
panD 4044725 c.-444C>T upstream_gene_variant 0.15 pyrazinamide
panD 4044728 c.-447C>T upstream_gene_variant 0.15 pyrazinamide
glpK 4138404 p.Val451Glu missense_variant 0.13 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138718 c.1038T>C synonymous_variant 0.14 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
embC 4241215 c.1353C>G synonymous_variant 0.14 ethambutol
embC 4241224 c.1362G>A synonymous_variant 0.17 ethambutol
embC 4241228 c.1366_1368delCTAinsTG frameshift_variant&stop_gained 0.15 ethambutol
embC 4241689 c.1827G>C synonymous_variant 0.14 ethambutol
embC 4241695 c.1833T>C synonymous_variant 0.15 ethambutol
embC 4241719 c.1857G>C synonymous_variant 0.15 ethambutol
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
embB 4249276 c.2763A>C synonymous_variant 0.16 ethambutol
embB 4249282 c.2769A>C synonymous_variant 0.2 ethambutol
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 capreomycin
amikacin
kanamycin
gid 4408156 p.Leu16Arg missense_variant 1.0 streptomycin Not assoc w R