TB-Profiler result

Run: ERR13245558
Summary

Run ID: ERR13245558

Sample name:

Date: 2025-02-11T13:44:40.949716

Number of reads: 2137952

Percentage reads mapped: 94.98

Median coverage: 88.0

Strain: La3;lineage2.2.2

Spoligotype:

Drug-resistance: MDR-TB

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage2 East-Asian RD105 0.99
lineage2.2.2 East-Asian (Beijing) RD105;RD207 0.99
lineage2.2 East-Asian (Beijing) RD105;RD207 1.0
La3 M.orygis None 0.05
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin rpoB p.Ser450Leu Assoc w R
isoniazid katG p.Ser315Thr Assoc w R High-level resistance
ethambutol embB p.Gly406Ala Assoc w R
pyrazinamide
streptomycin rrs n.462C>T Uncertain significance Mutation from literature
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
rpoB 761155 p.Ser450Leu missense_variant 0.83 rifampicin Assoc w R
rrs 1472307 n.462C>T non_coding_transcript_exon_variant 0.32 streptomycin Uncertain significance Mutation from literature
katG 2155168 p.Ser315Thr missense_variant 1.0 isoniazid Assoc w R High-level resistance
embB 4247730 p.Gly406Ala missense_variant 1.0 ethambutol Assoc w R
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 8672 c.1371A>G synonymous_variant 0.14 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8693 c.1392T>C synonymous_variant 0.13 levofloxacin
moxifloxacin
gyrA 8780 p.Asp493Glu missense_variant 0.16 levofloxacin
moxifloxacin
gyrA 8786 c.1485T>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8801 c.1500G>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8807 c.1506C>T synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8810 c.1509A>G synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8816 c.1515C>G synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8818 p.Ser506Asn missense_variant 0.16 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8828 c.1527T>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8837 c.1536C>T synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8852 c.1551T>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8858 c.1557T>C synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 8867 c.1566A>G synonymous_variant 0.28 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8870 c.1569G>C synonymous_variant 0.28 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8873 c.1572A>C synonymous_variant 0.28 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8891 c.1590G>A synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 8897 c.1596T>C synonymous_variant 0.3 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8903 c.1602T>C synonymous_variant 0.28 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8933 c.1632G>C synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 8939 c.1638T>C synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 8942 c.1641G>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8946 c.1645_1647delTTGinsCTC synonymous_variant 0.25 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8966 c.1665C>G synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8967 p.Ala556Arg missense_variant 0.23 levofloxacin
moxifloxacin
gyrA 8987 c.1686C>G synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8990 c.1689C>G synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8996 c.1695T>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8998 p.Leu566Trp missense_variant 0.19 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9017 c.1716C>G synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9023 c.1722A>C synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9029 c.1728T>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 9032 c.1731T>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 9035 c.1734G>C synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 9050 p.Asp583Glu missense_variant 0.17 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9051 c.1750T>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 9056 c.1755C>G synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9062 c.1761C>G synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 9068 c.1767G>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 9071 c.1770G>C synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 9080 c.1779G>T synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 9089 c.1788G>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 9099 c.1798_1800delTTAinsCTG synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 9104 c.1803C>G synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9119 c.1818A>G synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 9122 c.1821C>G synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9143 c.1842T>C synonymous_variant 0.15 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9152 c.1851C>T synonymous_variant 0.13 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9154 p.Thr618Asn missense_variant 0.13 levofloxacin
moxifloxacin
gyrA 9158 c.1857C>T synonymous_variant 0.14 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9161 c.1860C>G synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 9182 c.1881T>C synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9191 c.1890G>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 9200 c.1899A>G synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9204 p.Ser635Thr missense_variant 0.15 levofloxacin
moxifloxacin
gyrA 9224 c.1923C>T synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 9230 c.1929T>C synonymous_variant 0.14 levofloxacin
moxifloxacin
gyrA 9233 c.1932C>G synonymous_variant 0.14 levofloxacin
moxifloxacin
gyrA 9239 c.1938C>T synonymous_variant 0.14 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
fgd1 491742 c.960T>C synonymous_variant 1.0 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R
ccsA 620362 p.Ala158Thr missense_variant 0.13 kanamycin
capreomycin
amikacin
ccsA 620682 c.792G>A synonymous_variant 0.15 kanamycin
capreomycin
amikacin
ccsA 620688 c.798G>C synonymous_variant 0.16 kanamycin
capreomycin
amikacin
ccsA 620710 p.Val274Ile missense_variant 0.14 kanamycin
capreomycin
amikacin
ccsA 620734 c.844C>A synonymous_variant 0.13 kanamycin
capreomycin
amikacin
Rv0565c 657081 c.390G>A synonymous_variant 1.0 ethionamide Not assoc w R - Interim
Rv0565c 657142 p.Arg110His missense_variant 1.0 ethionamide Uncertain significance
Rv0565c 657734 c.-264T>C upstream_gene_variant 0.15 ethionamide
hadA 732110 p.Cys61Gly missense_variant 1.0 isoniazid Uncertain significance
rpoB 760181 c.375T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 760184 c.378A>G synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 760223 c.417T>C synonymous_variant 0.14 rifampicin
rpoB 760235 c.429T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760283 c.477G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760298 c.492G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760307 c.501T>C synonymous_variant 0.22 rifampicin
rpoB 760310 c.504G>C synonymous_variant 0.22 rifampicin
rpoB 760328 c.522G>C synonymous_variant 0.26 rifampicin
rpoB 760331 c.525G>C synonymous_variant 0.25 rifampicin
rpoB 760340 c.534G>T synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 760361 c.555T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 760370 c.564C>G synonymous_variant 0.33 rifampicin
rpoB 760376 p.Asp190Glu missense_variant 0.33 rifampicin Uncertain significance
rpoB 760380 p.Thr192Leu missense_variant 0.32 rifampicin
rpoB 760406 c.600G>C synonymous_variant 0.37 rifampicin
rpoB 760412 c.606C>G synonymous_variant 0.36 rifampicin
rpoB 760424 c.618C>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 760430 c.624T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 760475 c.669A>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 760481 c.675G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 760484 c.678A>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 760522 p.Ser239Asn missense_variant 0.2 rifampicin Uncertain significance
rpoB 760532 c.726T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760533 p.Val243Thr missense_variant 0.15 rifampicin
rpoB 760547 c.741G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 760564 p.Arg253Leu missense_variant 0.12 rifampicin
rpoB 760591 p.Val262Ala missense_variant 0.13 rifampicin
rpoB 760611 c.805T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 760925 c.1119T>C synonymous_variant 0.15 rifampicin
rpoB 760928 c.1122G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 760931 c.1125C>G synonymous_variant 0.15 rifampicin
rpoB 760934 c.1128C>T synonymous_variant 0.15 rifampicin
rpoB 760946 c.1140A>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 760982 c.1176G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760985 c.1179G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760991 c.1185G>C synonymous_variant 0.17 rifampicin
rpoB 761006 c.1200C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 761015 c.1209G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 761021 c.1215G>C synonymous_variant 0.18 rifampicin
rpoB 761027 c.1221A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761036 c.1230G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761037 c.1231T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761057 c.1251G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761102 c.1296A>G synonymous_variant 0.22 rifampicin
rpoB 761129 c.1323G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761132 c.1326G>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 761133 c.1327T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761150 c.1344A>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 761153 c.1347G>T synonymous_variant 0.17 rifampicin
rpoB 761165 c.1359G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761588 c.1782C>T synonymous_variant 0.13 rifampicin
rpoB 761636 c.1830G>T synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 761645 c.1839C>G synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 761648 c.1842T>C synonymous_variant 0.16 rifampicin
rpoB 761657 c.1851C>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 761675 c.1869G>C synonymous_variant 0.15 rifampicin
rpoB 761765 c.1959T>C synonymous_variant 0.14 rifampicin
rpoB 761791 p.Arg662His missense_variant 0.15 rifampicin
rpoB 761815 p.Ala670Asp missense_variant 0.13 rifampicin
rpoB 762149 c.2343G>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 762176 c.2370T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 762185 c.2379G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 762206 c.2400C>G synonymous_variant 0.17 rifampicin
rpoB 762233 c.2427G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 762246 c.2440C>T synonymous_variant 0.19 rifampicin
rpoB 762254 c.2448T>G synonymous_variant 0.2 rifampicin
rpoB 762257 c.2451C>G synonymous_variant 0.2 rifampicin
rpoB 762266 c.2460T>C synonymous_variant 0.19 rifampicin
rpoB 762284 c.2478G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 762293 c.2487T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 762296 c.2490G>A synonymous_variant 0.19 rifampicin
rpoB 762317 c.2511A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 762329 c.2523G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 762338 c.2532T>C synonymous_variant 0.2 rifampicin
rpoB 762347 c.2541T>C synonymous_variant 0.22 rifampicin
rpoB 762362 p.Glu852Asp missense_variant 0.19 rifampicin
rpoB 762369 c.2563T>C synonymous_variant 0.19 rifampicin
rpoC 762398 c.-972T>C upstream_gene_variant 0.18 rifampicin
rpoC 762401 c.-969G>C upstream_gene_variant 0.18 rifampicin
rpoB 762404 c.2598T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 762410 c.-960T>C upstream_gene_variant 0.2 rifampicin
rpoB 762416 c.2610A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 762434 c.-936T>C upstream_gene_variant 0.18 rifampicin
rpoC 762443 c.-927G>C upstream_gene_variant 0.18 rifampicin
rpoB 762449 c.2643C>A synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 762452 c.2646G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 762458 c.-912C>G upstream_gene_variant 0.17 rifampicin
rpoB 762929 c.3123G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>C synonymous_variant 1.0 rifampicin Not assoc w R
rpoC 763402 c.33C>G synonymous_variant 0.14 rifampicin
rpoC 763411 c.42T>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 763414 c.45T>C synonymous_variant 0.16 rifampicin
rpoC 763441 c.72C>T synonymous_variant 0.19 rifampicin
rpoC 763444 c.75T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 763456 c.87A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 763486 c.117T>G synonymous_variant 0.17 rifampicin
rpoC 763492 c.123G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 763528 c.159G>A synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 763573 c.204G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 763594 c.225C>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 763603 c.234C>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 763853 p.Val162Ile missense_variant 0.13 rifampicin
rpoC 763900 c.531G>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 763945 c.576T>C synonymous_variant 0.15 rifampicin
rpoC 763951 c.582G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 763960 c.591T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 763991 p.Ile208Leu missense_variant 0.14 rifampicin
rpoC 763996 c.627T>C synonymous_variant 0.15 rifampicin
rpoC 764002 c.633C>G synonymous_variant 0.16 rifampicin
rpoC 764005 c.636G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 764024 c.655_657delTTGinsCTC synonymous_variant 0.17 rifampicin
rpoC 764032 p.Asp221Glu missense_variant 0.16 rifampicin
rpoC 764040 p.Ser224Thr missense_variant 0.17 rifampicin
rpoC 764044 c.675T>C synonymous_variant 0.18 rifampicin
rpoC 764059 c.690G>T synonymous_variant 0.19 rifampicin
rpoC 764083 c.714A>G synonymous_variant 0.19 rifampicin
rpoC 764098 c.729A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764101 c.732C>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764102 p.Val245Ile missense_variant 0.15 rifampicin
rpoC 764112 p.Tyr248Phe missense_variant 0.2 rifampicin
rpoC 764116 c.747C>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764131 c.762T>C synonymous_variant 0.19 rifampicin
rpoC 764188 c.819A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764195 p.Ser276Ile missense_variant 0.17 rifampicin
rpoC 764203 c.834G>C synonymous_variant 0.17 rifampicin
rpoC 764206 c.837T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764215 c.846A>G synonymous_variant 0.2 rifampicin
rpoC 764236 c.867G>A synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764248 c.879C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764257 c.888G>C synonymous_variant 0.19 rifampicin
rpoC 764266 c.897T>C synonymous_variant 0.17 rifampicin
rpoC 764269 c.900G>C synonymous_variant 0.17 rifampicin
rpoC 764272 c.903G>C synonymous_variant 0.17 rifampicin
rpoC 764278 c.909A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764338 c.969G>A synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764353 c.984G>C synonymous_variant 0.16 rifampicin
rpoC 764365 c.996C>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 764380 c.1011G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 764381 c.1012_1013delTCinsAG synonymous_variant 0.14 rifampicin
rpoC 764389 p.Leu340Phe missense_variant 0.14 rifampicin Uncertain significance
rpoC 764405 c.1036A>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 764428 c.1059G>C synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoC 764489 c.1120C>T synonymous_variant 0.14 rifampicin
rpoC 764611 c.1242G>T synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>C synonymous_variant 0.14 rifampicin
rpoC 764651 c.1282_1284delTCGinsAGC synonymous_variant 0.14 rifampicin
rpoC 764752 c.1383G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764764 c.1395T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764809 c.1440C>T synonymous_variant 0.19 rifampicin Not assoc w R
rpoC 764815 c.1446A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764827 c.1458G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 764844 p.Ala492Val missense_variant 0.84 rifampicin Uncertain significance
rpoC 764858 c.1489T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 764872 c.1503A>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 764888 c.1519T>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 764911 c.1542A>G synonymous_variant 0.14 rifampicin
rpoC 764932 c.1563C>A synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 765541 c.2172C>G synonymous_variant 0.14 rifampicin
rpoC 765553 c.2184C>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 765556 c.2187G>C synonymous_variant 0.15 rifampicin
rpoC 765559 c.2190G>C synonymous_variant 0.17 rifampicin
rpoC 765580 c.2211G>C synonymous_variant 0.16 rifampicin
rpoC 765613 p.His748Gln missense_variant 0.21 rifampicin
rpoC 765625 c.2256C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 765631 p.Asp754Glu missense_variant 0.24 rifampicin
rpoC 765700 c.2331T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 765734 c.2365T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 765739 c.2370G>T synonymous_variant 0.21 rifampicin
rpoC 765751 c.2382C>G synonymous_variant 0.2 rifampicin
rpoC 765753 p.Asp795Ala missense_variant 0.21 rifampicin Uncertain significance
rpoC 765772 c.2403C>G synonymous_variant 0.2 rifampicin
rpoC 765784 c.2415C>G synonymous_variant 0.17 rifampicin
rpoC 765787 c.2418C>T synonymous_variant 0.16 rifampicin
rpoC 765793 c.2424C>G synonymous_variant 0.15 rifampicin
rpoC 765796 c.2427C>T synonymous_variant 0.15 rifampicin
rpoC 766381 c.3012C>T synonymous_variant 0.14 rifampicin
rpoC 766390 c.3021C>T synonymous_variant 0.15 rifampicin
rpoC 766393 c.3024C>G synonymous_variant 0.15 rifampicin
rpoC 766408 c.3039C>G synonymous_variant 0.16 rifampicin
rpoC 766411 c.3042C>G synonymous_variant 0.16 rifampicin
rpoC 766426 c.3057C>T synonymous_variant 0.18 rifampicin
rpoC 766447 c.3078T>C synonymous_variant 0.18 rifampicin
rpoC 766462 c.3093G>C synonymous_variant 0.24 rifampicin
rpoC 766483 c.3114G>C synonymous_variant 0.19 rifampicin
rpoC 766484 p.Val1039Ile missense_variant 0.19 rifampicin Uncertain significance
rpoC 766492 c.3123T>C synonymous_variant 0.21 rifampicin
rpoC 766522 c.3153C>G synonymous_variant 0.23 rifampicin
rpoC 766528 c.3159T>C synonymous_variant 0.22 rifampicin
rpoC 766531 c.3162G>C synonymous_variant 0.22 rifampicin
rpoC 766540 p.Asp1057Glu missense_variant 0.22 rifampicin
rpoC 766549 c.3180G>C synonymous_variant 0.21 rifampicin
rpoC 766573 c.3204T>C synonymous_variant 0.22 rifampicin
rpoC 766582 c.3213C>G synonymous_variant 0.21 rifampicin
rpoC 766583 p.Gly1072Ser missense_variant 0.2 rifampicin
rpoC 766591 c.3222A>G synonymous_variant 0.18 rifampicin
rpoC 766594 c.3225G>C synonymous_variant 0.18 rifampicin
rpoC 766597 c.3228C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 766607 p.Ile1080Leu missense_variant 0.2 rifampicin
rpoC 766630 c.3261G>C synonymous_variant 0.21 rifampicin
rpoC 766657 c.3288A>G synonymous_variant 0.21 rifampicin
rpoC 766672 c.3303T>C synonymous_variant 0.22 rifampicin
rpoC 766673 p.Gly1102Asn missense_variant 0.22 rifampicin
rpoC 766726 c.3357T>C synonymous_variant 0.17 rifampicin
rpoC 766738 c.3369G>C synonymous_variant 0.18 rifampicin
rpoC 766765 c.3396A>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 766774 c.3405T>C synonymous_variant 0.17 rifampicin
rpoC 766801 c.3432C>G synonymous_variant 0.19 rifampicin
rpoC 766804 c.3435A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 766861 c.3492G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 766864 c.3495G>C synonymous_variant 0.22 rifampicin
rpoC 766900 c.3531T>C synonymous_variant 0.26 rifampicin
rpoC 766933 c.3564A>G synonymous_variant 0.28 rifampicin
rpoC 766945 c.3576A>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 766963 c.3594T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 766972 c.3603G>C synonymous_variant 0.32 rifampicin
rpoC 766996 c.3627C>T synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 767009 c.3640_3642delTCGinsAGC synonymous_variant 0.3 rifampicin
rpoC 767014 c.3645G>C synonymous_variant 0.3 rifampicin
rpoC 767033 c.3664_3666delTCGinsAGC synonymous_variant 0.3 rifampicin
rpoC 767059 c.3690T>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 767062 c.3693C>A synonymous_variant 0.28 rifampicin
rpoC 767098 c.3729T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 767119 c.3750A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 767134 c.3765C>A synonymous_variant 0.15 rifampicin
mmpL5 775639 p.Ile948Val missense_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
mmpL5 776100 p.Thr794Ile missense_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
mmpS5 779615 c.-710C>G upstream_gene_variant 1.0 bedaquiline
clofazimine
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781700 c.141G>C synonymous_variant 0.18 streptomycin
rpsL 781703 c.144G>T synonymous_variant 0.18 streptomycin
rpsL 781715 c.156T>C synonymous_variant 0.18 streptomycin
rpsL 781728 c.169T>C synonymous_variant 0.19 streptomycin
rpsL 781736 c.177T>C synonymous_variant 0.19 streptomycin
rpsL 781742 c.183C>T synonymous_variant 0.2 streptomycin
rpsL 781748 c.189C>G synonymous_variant 0.21 streptomycin
rpsL 781754 c.195G>C synonymous_variant 0.22 streptomycin
rpsL 781760 c.201T>C synonymous_variant 0.23 streptomycin
rpsL 781772 c.213C>A synonymous_variant 0.22 streptomycin
rpsL 781808 c.249C>T synonymous_variant 0.23 streptomycin
rpsL 781811 c.252C>T synonymous_variant 0.23 streptomycin
rpsL 781832 c.273T>C synonymous_variant 0.25 streptomycin
rpsL 781838 c.279G>C synonymous_variant 0.26 streptomycin
rpsL 781841 c.282C>G synonymous_variant 0.26 streptomycin
rpsL 781865 c.306G>C synonymous_variant 0.26 streptomycin
rpsL 781868 c.309T>C synonymous_variant 0.27 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.26 streptomycin
rpsL 781877 c.318T>C synonymous_variant 0.27 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.26 streptomycin
rpsL 781898 c.339A>T synonymous_variant 0.25 streptomycin
rpsL 781916 c.357T>C synonymous_variant 0.26 streptomycin
rpsL 781929 p.Gly124Ser missense_variant 0.29 streptomycin Uncertain significance
rplC 800814 c.6A>G synonymous_variant 0.14 linezolid
rplC 800817 c.9A>T synonymous_variant 0.15 linezolid
rplC 801442 p.Ile212Val missense_variant 0.13 linezolid
Rv1129c 1254562 c.-28T>C upstream_gene_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
isoniazid Not assoc w R
rifampicin Not assoc w R
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 kanamycin
capreomycin
streptomycin
amikacin
rrs 1471969 n.124T>C non_coding_transcript_exon_variant 0.18 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1471970 n.125G>A non_coding_transcript_exon_variant 0.19 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472028 n.183A>T non_coding_transcript_exon_variant 0.25 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472029 n.184C>T non_coding_transcript_exon_variant 0.24 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472030 n.185G>T non_coding_transcript_exon_variant 0.24 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472031 n.186G>A non_coding_transcript_exon_variant 0.24 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472033 n.188A>G non_coding_transcript_exon_variant 0.25 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472034 n.189T>C non_coding_transcript_exon_variant 0.25 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472044 n.199G>T non_coding_transcript_exon_variant 0.27 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472045 n.200T>A non_coding_transcript_exon_variant 0.28 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472053 n.211_212delGC non_coding_transcript_exon_variant 0.28 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472061 n.216A>T non_coding_transcript_exon_variant 0.29 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472075 n.230A>G non_coding_transcript_exon_variant 0.31 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.31 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472753 n.908A>C non_coding_transcript_exon_variant 0.92 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473105 n.1260G>A non_coding_transcript_exon_variant 0.24 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1473123 n.1278delAinsTT non_coding_transcript_exon_variant 0.21 kanamycin
capreomycin
streptomycin
amikacin
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.22 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.21 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473290 n.1445C>T non_coding_transcript_exon_variant 0.15 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrl 1473668 n.11C>T non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid
rrl 1473756 n.99G>A non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1473758 n.101G>T non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid
rrl 1473806 n.149C>T non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473877 n.220G>A non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1473898 n.241C>T non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473943 n.286G>T non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid
rrl 1473945 n.288T>A non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid
rrl 1473946 n.289A>T non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid
rrl 1473986 n.329T>C non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1473987 n.330G>A non_coding_transcript_exon_variant 0.29 capreomycin
linezolid
rrl 1473995 n.338G>T non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1474001 n.344C>T non_coding_transcript_exon_variant 0.28 capreomycin Not assoc w R
linezolid Not assoc w R
rrl 1474009 n.352A>G non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1474012 n.355C>T non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1474093 n.436G>T non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1474099 n.442G>A non_coding_transcript_exon_variant 0.29 capreomycin
linezolid
rrl 1474103 n.446A>T non_coding_transcript_exon_variant 0.32 capreomycin
linezolid
rrl 1474140 n.483C>T non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474181 n.524C>T non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid
rrl 1475249 n.1592T>C non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475252 n.1595C>T non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1475266 n.1609T>C non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475267 n.1610G>A non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1475275 n.1618C>T non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1475276 n.1619T>C non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1475291 n.1634A>C non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475313 n.1656G>A non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1475315 n.1658A>T non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475355 n.1698C>T non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475369 n.1712G>T non_coding_transcript_exon_variant 0.43 capreomycin
linezolid
rrl 1475402 n.1745C>T non_coding_transcript_exon_variant 0.45 capreomycin
linezolid
rrl 1475419 n.1762C>T non_coding_transcript_exon_variant 0.45 capreomycin Uncertain significance
linezolid
rrl 1475429 n.1772G>A non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475436 n.1779C>T non_coding_transcript_exon_variant 0.47 capreomycin
linezolid
rrl 1475483 n.1826C>T non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475505 n.1848G>A non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475599 n.1942A>G non_coding_transcript_exon_variant 0.31 capreomycin
linezolid Uncertain significance
rrl 1475608 n.1951T>C non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid
rrl 1475642 n.1985T>C non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1475657 n.2000A>G non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1475659 n.2002G>T non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1475761 n.2104_2106delCGCinsGT non_coding_transcript_exon_variant 0.37 capreomycin
linezolid
rrl 1475765 n.2111delG non_coding_transcript_exon_variant 0.38 capreomycin
linezolid
rrl 1475881 n.2224T>C non_coding_transcript_exon_variant 0.47 capreomycin
linezolid
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.23 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476583 n.2926G>A non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.21 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476594 n.2937C>T non_coding_transcript_exon_variant 0.19 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476597 n.2940G>A non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid
rrl 1476603 n.2946G>A non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476608 n.2951C>G non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476689 n.3032A>T non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1476690 n.3033C>T non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid
rrl 1476693 n.3036G>A non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
rrl 1476695 n.3038T>A non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
rrl 1476716 n.3059A>C non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid
rrl 1476726 n.3069A>G non_coding_transcript_exon_variant 0.15 capreomycin
linezolid
rrl 1476732 n.3075T>C non_coding_transcript_exon_variant 0.14 capreomycin
linezolid
rpsA 1833589 c.48A>T synonymous_variant 0.16 pyrazinamide
rpsA 1833595 c.54T>C synonymous_variant 0.17 pyrazinamide
rpsA 1833661 c.120A>G synonymous_variant 0.21 pyrazinamide
rpsA 1833667 c.126C>G synonymous_variant 0.21 pyrazinamide
rpsA 1833721 c.180A>G synonymous_variant 0.21 pyrazinamide
rpsA 1833724 c.183C>G synonymous_variant 0.21 pyrazinamide
rpsA 1833727 c.186G>C synonymous_variant 0.21 pyrazinamide
rpsA 1833742 c.201A>G synonymous_variant 0.2 pyrazinamide
rpsA 1833745 c.204G>C synonymous_variant 0.21 pyrazinamide
rpsA 1833748 c.207C>G synonymous_variant 0.22 pyrazinamide
rpsA 1833787 c.246C>G synonymous_variant 0.24 pyrazinamide
rpsA 1833790 c.249T>C synonymous_variant 0.24 pyrazinamide
rpsA 1833802 c.261A>G synonymous_variant 0.23 pyrazinamide
rpsA 1833811 c.270G>T synonymous_variant 0.25 pyrazinamide
rpsA 1833838 c.297G>C synonymous_variant 0.26 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.26 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.27 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.28 pyrazinamide
rpsA 1833874 c.333T>C synonymous_variant 0.31 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.31 pyrazinamide
rpsA 1833940 c.399C>G synonymous_variant 0.34 pyrazinamide
rpsA 1833971 c.430C>T synonymous_variant 0.35 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.35 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.31 pyrazinamide
rpsA 1834021 c.480C>T synonymous_variant 0.31 pyrazinamide
rpsA 1834030 c.489C>G synonymous_variant 0.31 pyrazinamide
rpsA 1834099 c.558C>G synonymous_variant 0.27 pyrazinamide
rpsA 1834102 c.561T>C synonymous_variant 0.28 pyrazinamide
rpsA 1834105 c.564C>G synonymous_variant 0.28 pyrazinamide
rpsA 1834108 c.567C>G synonymous_variant 0.28 pyrazinamide
rpsA 1834123 c.582C>G synonymous_variant 0.27 pyrazinamide
rpsA 1834150 c.609G>C synonymous_variant 0.24 pyrazinamide
rpsA 1834153 c.612T>C synonymous_variant 0.25 pyrazinamide
rpsA 1834154 p.Asn205Gln missense_variant 0.24 pyrazinamide
rpsA 1834157 c.616T>C synonymous_variant 0.24 pyrazinamide
rpsA 1834162 c.621A>G synonymous_variant 0.24 pyrazinamide Not assoc w R - Interim
rpsA 1834165 c.624A>G synonymous_variant 0.24 pyrazinamide
rpsA 1834169 p.Thr210Ala missense_variant 0.25 pyrazinamide Uncertain significance
rpsA 1834177 c.636A>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
rpsA 1834189 c.648G>C synonymous_variant 0.22 pyrazinamide
rpsA 1834195 c.654G>C synonymous_variant 0.22 pyrazinamide
rpsA 1834210 c.669C>T synonymous_variant 0.22 pyrazinamide
rpsA 1834222 c.681T>C synonymous_variant 0.22 pyrazinamide
rpsA 1834231 c.690T>C synonymous_variant 0.23 pyrazinamide
rpsA 1834234 c.693G>C synonymous_variant 0.23 pyrazinamide
rpsA 1834249 c.708T>C synonymous_variant 0.27 pyrazinamide
rpsA 1834261 c.720A>G synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
rpsA 1834262 c.721_723delTCGinsAGC synonymous_variant 0.2 pyrazinamide
rpsA 1834303 c.762T>C synonymous_variant 0.16 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.16 pyrazinamide
rpsA 1834333 c.792C>T synonymous_variant 0.14 pyrazinamide
rpsA 1834609 c.1068T>C synonymous_variant 0.17 pyrazinamide
rpsA 1834633 c.1092A>G synonymous_variant 0.2 pyrazinamide
rpsA 1834639 c.1098T>C synonymous_variant 0.19 pyrazinamide
rpsA 1834654 p.Glu371Asp missense_variant 0.23 pyrazinamide
rpsA 1834684 c.1143C>T synonymous_variant 0.28 pyrazinamide
rpsA 1834690 c.1149T>C synonymous_variant 0.27 pyrazinamide
rpsA 1834732 c.1191T>C synonymous_variant 0.23 pyrazinamide
rpsA 1834733 p.Ala398Ser missense_variant 0.23 pyrazinamide
rpsA 1834738 c.1197A>G synonymous_variant 0.23 pyrazinamide
rpsA 1834753 c.1212T>C synonymous_variant 0.22 pyrazinamide
rpsA 1834765 p.Glu408Asp missense_variant 0.18 pyrazinamide
rpsA 1834775 p.Ala412Thr missense_variant 0.18 pyrazinamide
rpsA 1834780 c.1239A>G synonymous_variant 0.17 pyrazinamide
rpsA 1834786 c.1245A>G synonymous_variant 0.17 pyrazinamide
rpsA 1834789 c.1248T>C synonymous_variant 0.16 pyrazinamide
rpsA 1834792 c.1251G>C synonymous_variant 0.16 pyrazinamide
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
katG 2154724 p.Arg463Leu missense_variant 0.99 isoniazid Not assoc w R
PPE35 2167926 p.Leu896Ser missense_variant 1.0 pyrazinamide Not assoc w R
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
kasA 2517993 c.-122G>T upstream_gene_variant 0.13 isoniazid
kasA 2518825 c.711T>C synonymous_variant 0.15 isoniazid
folC 2747275 c.324T>C synonymous_variant 0.15 para-aminosalicylic_acid
folC 2747289 p.Pro104Ala missense_variant 0.13 para-aminosalicylic_acid
folC 2747293 c.306G>A synonymous_variant 0.13 para-aminosalicylic_acid
folC 2747302 c.297A>G synonymous_variant 0.14 para-aminosalicylic_acid
folC 2747314 c.285A>C synonymous_variant 0.16 para-aminosalicylic_acid
folC 2747317 c.282C>G synonymous_variant 0.15 para-aminosalicylic_acid
folC 2747343 p.Val86Ile missense_variant 0.13 para-aminosalicylic_acid
Rv2477c 2783194 c.849A>G synonymous_variant 0.15 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783221 c.822G>C synonymous_variant 0.15 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783224 c.819C>G synonymous_variant 0.15 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783230 c.813T>G synonymous_variant 0.16 kanamycin
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin
Rv2477c 2783235 c.808T>C synonymous_variant 0.19 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783254 c.789A>G synonymous_variant 0.15 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783263 c.780G>C synonymous_variant 0.15 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783751 p.Ile98Val missense_variant 0.17 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783758 p.Asp95Glu missense_variant 0.17 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783761 c.282G>C synonymous_variant 0.15 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783766 p.Met93Leu missense_variant 0.15 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783776 c.267G>C synonymous_variant 0.16 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783779 c.264T>C synonymous_variant 0.16 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783797 p.Asp82Glu missense_variant 0.17 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783815 c.228A>G synonymous_variant 0.17 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783821 p.Gln74Leu missense_variant 0.17 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783833 c.210G>C synonymous_variant 0.17 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783839 c.204C>G synonymous_variant 0.16 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783843 p.Gly67Asp missense_variant 0.16 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783846 p.Thr66Asn missense_variant 0.16 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783860 c.183T>C synonymous_variant 0.19 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783863 c.180C>T synonymous_variant 0.18 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783883 c.160T>C synonymous_variant 0.21 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783884 c.159T>C synonymous_variant 0.21 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783887 c.156C>G synonymous_variant 0.22 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783914 c.129T>C synonymous_variant 0.23 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783920 c.123G>C synonymous_variant 0.22 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783929 c.114C>G synonymous_variant 0.21 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783932 c.111C>T synonymous_variant 0.21 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783938 c.105T>C synonymous_variant 0.18 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783953 c.90G>A synonymous_variant 0.18 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783962 c.81T>C synonymous_variant 0.18 kanamycin Not assoc w R - Interim
levofloxacin
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783971 c.72G>C synonymous_variant 0.15 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
pepQ 2859676 p.Glu248Ala missense_variant 0.98 bedaquiline
clofazimine
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
Rv3236c 3612813 p.Thr102Ala missense_variant 1.0 pyrazinamide Not assoc w R - Interim
mtrB 3625065 p.Met517Leu missense_variant 1.0 rifampicin Not assoc w R
bedaquiline Uncertain significance
rpoA 3877613 p.Ile299Val missense_variant 0.15 rifampicin
rpoA 3877656 c.852T>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3877668 c.840A>G synonymous_variant 0.17 rifampicin
rpoA 3877679 p.Ala277Ser missense_variant 0.18 rifampicin
rpoA 3877686 c.822A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3877692 c.816G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoA 3877704 c.804G>C synonymous_variant 0.22 rifampicin
rpoA 3877737 c.771G>C synonymous_variant 0.26 rifampicin
rpoA 3877743 c.765T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoA 3877764 c.744C>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoA 3877770 c.738A>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoA 3877776 c.732T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoA 3877782 c.726T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoA 3877791 c.717C>G synonymous_variant 0.32 rifampicin
rpoA 3877818 c.690A>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoA 3877839 c.669G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoA 3877848 c.660C>T synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoA 3877857 c.651G>A synonymous_variant 0.3 rifampicin
rpoA 3877866 c.642G>C synonymous_variant 0.27 rifampicin
rpoA 3877875 c.633T>G synonymous_variant 0.24 rifampicin
rpoA 3877878 c.630G>C synonymous_variant 0.24 rifampicin
rpoA 3877909 p.Asn200Ser missense_variant 0.21 rifampicin
rpoA 3877920 c.588G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoA 3877923 c.585C>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoA 3877926 c.582G>C synonymous_variant 0.16 rifampicin
rpoA 3878232 c.276G>C synonymous_variant 0.16 rifampicin
rpoA 3878247 c.261G>C synonymous_variant 0.2 rifampicin
rpoA 3878271 c.237T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoA 3878284 p.Glu75Ala missense_variant 0.25 rifampicin
rpoA 3878292 c.216T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoA 3878298 c.210A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoA 3878304 c.204G>C synonymous_variant 0.27 rifampicin
rpoA 3878313 c.195G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoA 3878322 c.186A>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoA 3878331 c.177A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoA 3878334 c.174T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoA 3878337 c.171T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoA 3878346 c.162T>C synonymous_variant 0.25 rifampicin
rpoA 3878364 c.144A>T synonymous_variant 0.26 rifampicin
rpoA 3878367 c.141C>G synonymous_variant 0.24 rifampicin
rpoA 3878376 c.132G>C synonymous_variant 0.23 rifampicin
rpoA 3878385 c.123C>G synonymous_variant 0.22 rifampicin
rpoA 3878388 c.120C>G synonymous_variant 0.22 rifampicin
rpoA 3878391 c.117T>C synonymous_variant 0.22 rifampicin
rpoA 3878415 c.93C>T synonymous_variant 0.22 rifampicin
rpoA 3878424 c.84G>C synonymous_variant 0.19 rifampicin
rpoA 3878436 c.72A>G synonymous_variant 0.17 rifampicin
rpoA 3878442 c.66G>C synonymous_variant 0.17 rifampicin
rpoA 3878454 c.54A>C synonymous_variant 0.18 rifampicin
rpoA 3878472 p.Asp12Glu missense_variant 0.18 rifampicin
rpoA 3878478 c.30C>G synonymous_variant 0.17 rifampicin
rpoA 3878484 c.24C>A synonymous_variant 0.17 rifampicin
rpoA 3878490 c.18C>A synonymous_variant 0.18 rifampicin
rpoA 3878496 c.12A>T synonymous_variant 0.2 rifampicin
rpoA 3878878 c.-371T>C upstream_gene_variant 0.15 rifampicin Uncertain significance
rpoA 3878909 c.-402A>G upstream_gene_variant 0.15 rifampicin
rpoA 3878914 c.-407T>C upstream_gene_variant 0.15 rifampicin Uncertain significance
rpoA 3878938 c.-431T>C upstream_gene_variant 0.15 rifampicin
rpoA 3878947 c.-440G>C upstream_gene_variant 0.15 rifampicin Uncertain significance
rpoA 3878998 c.-491C>G upstream_gene_variant 0.14 rifampicin Uncertain significance
rpoA 3879005 c.-499_-498delAAinsCG upstream_gene_variant 0.15 rifampicin
rpoA 3879013 c.-506A>G upstream_gene_variant 0.15 rifampicin
rpoA 3879079 c.-572A>G upstream_gene_variant 0.17 rifampicin
rpoA 3879088 c.-581A>C upstream_gene_variant 0.18 rifampicin
rpoA 3879094 c.-587T>C upstream_gene_variant 0.17 rifampicin
rpoA 3879121 c.-614T>G upstream_gene_variant 0.16 rifampicin
rpoA 3879127 c.-620T>C upstream_gene_variant 0.16 rifampicin
rpoA 3879154 c.-647T>C upstream_gene_variant 0.19 rifampicin
rpoA 3879160 c.-653A>G upstream_gene_variant 0.17 rifampicin
rpoA 3879178 c.-671T>C upstream_gene_variant 0.17 rifampicin
rpoA 3879222 c.-715T>C upstream_gene_variant 0.16 rifampicin
rpoA 3879226 c.-719G>C upstream_gene_variant 0.15 rifampicin
rpoA 3879229 c.-722A>G upstream_gene_variant 0.15 rifampicin
rpoA 3879232 c.-725A>G upstream_gene_variant 0.16 rifampicin
clpC1 4038368 c.2337T>C synonymous_variant 0.14 pyrazinamide
clpC1 4038498 p.Ser736Asn missense_variant 0.13 pyrazinamide
clpC1 4038509 c.2196C>T synonymous_variant 0.14 pyrazinamide
clpC1 4038530 p.Glu725Asp missense_variant 0.15 pyrazinamide
clpC1 4038541 c.2164C>T synonymous_variant 0.17 pyrazinamide
clpC1 4038596 c.2109A>G synonymous_variant 0.2 pyrazinamide
clpC1 4038623 c.2082A>G synonymous_variant 0.21 pyrazinamide
clpC1 4038640 p.Asp689Asn missense_variant 0.23 pyrazinamide
clpC1 4038653 c.2052C>T synonymous_variant 0.21 pyrazinamide
clpC1 4038658 p.Lys683Gln missense_variant 0.21 pyrazinamide
clpC1 4038661 p.Ser682Thr missense_variant 0.21 pyrazinamide
clpC1 4038662 c.2043T>C synonymous_variant 0.21 pyrazinamide
clpC1 4038671 c.2034T>C synonymous_variant 0.21 pyrazinamide
clpC1 4038683 c.2022T>C synonymous_variant 0.22 pyrazinamide Not assoc w R - Interim
clpC1 4038695 c.2010C>G synonymous_variant 0.23 pyrazinamide
clpC1 4038701 c.2004G>C synonymous_variant 0.23 pyrazinamide
clpC1 4038704 c.2001T>C synonymous_variant 0.23 pyrazinamide
clpC1 4038707 c.1998C>G synonymous_variant 0.23 pyrazinamide
clpC1 4038710 c.1995G>C synonymous_variant 0.22 pyrazinamide
clpC1 4038713 c.1992T>C synonymous_variant 0.22 pyrazinamide
clpC1 4038749 c.1956C>G synonymous_variant 0.15 pyrazinamide
clpC1 4038755 c.1950G>T synonymous_variant 0.15 pyrazinamide
clpC1 4038770 c.1935C>T synonymous_variant 0.15 pyrazinamide
clpC1 4038773 c.1932T>C synonymous_variant 0.14 pyrazinamide
clpC1 4038956 c.1749T>C synonymous_variant 0.14 pyrazinamide
clpC1 4038965 c.1740T>C synonymous_variant 0.16 pyrazinamide
clpC1 4038971 c.1734T>C synonymous_variant 0.15 pyrazinamide
clpC1 4038974 c.1731T>C synonymous_variant 0.14 pyrazinamide Not assoc w R - Interim
clpC1 4038989 c.1716T>C synonymous_variant 0.17 pyrazinamide
clpC1 4038997 c.1708T>C synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
clpC1 4039004 c.1701C>G synonymous_variant 0.16 pyrazinamide
clpC1 4039022 c.1683A>G synonymous_variant 0.18 pyrazinamide
clpC1 4039064 c.1641C>T synonymous_variant 0.17 pyrazinamide
clpC1 4039103 c.1602T>C synonymous_variant 0.14 pyrazinamide
clpC1 4039106 c.1599G>C synonymous_variant 0.14 pyrazinamide
clpC1 4040021 c.684A>C synonymous_variant 0.14 pyrazinamide Not assoc w R - Interim
panD 4044848 c.-567T>A upstream_gene_variant 0.13 pyrazinamide
panD 4044936 c.-655A>T upstream_gene_variant 0.12 pyrazinamide
embC 4240819 c.957A>G synonymous_variant 0.16 ethambutol
embC 4240828 c.966G>A synonymous_variant 0.17 ethambutol
embC 4240831 c.969T>G synonymous_variant 0.16 ethambutol
embC 4240867 c.1005T>C synonymous_variant 0.14 ethambutol
embC 4240880 p.Ala340Thr missense_variant 0.14 ethambutol Uncertain significance
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
embA 4243460 c.228C>T synonymous_variant 1.0 ethambutol Not assoc w R
embB 4247497 c.984T>C synonymous_variant 0.15 ethambutol
embB 4247512 c.999T>C synonymous_variant 0.16 ethambutol
embB 4247539 c.1026T>C synonymous_variant 0.15 ethambutol
embB 4247611 c.1098G>T synonymous_variant 0.13 ethambutol Not assoc w R - Interim
embB 4247746 c.1233C>T synonymous_variant 0.16 ethambutol
embB 4247761 c.1248T>C synonymous_variant 0.19 ethambutol
embB 4247773 c.1260G>A synonymous_variant 0.2 ethambutol
embB 4247776 c.1263G>T synonymous_variant 0.2 ethambutol
embB 4247797 c.1284C>G synonymous_variant 0.2 ethambutol
embB 4247800 c.1287A>T synonymous_variant 0.2 ethambutol
embB 4247803 c.1290G>C synonymous_variant 0.2 ethambutol
embB 4247815 c.1302C>G synonymous_variant 0.21 ethambutol
embB 4247819 p.Val436Ile missense_variant 0.19 ethambutol Uncertain significance
embB 4247830 c.1317A>G synonymous_variant 0.19 ethambutol Not assoc w R - Interim
embB 4247836 c.1323A>G synonymous_variant 0.19 ethambutol Not assoc w R - Interim
embB 4247839 c.1326G>C synonymous_variant 0.19 ethambutol Not assoc w R - Interim
embB 4247866 c.1353G>C synonymous_variant 0.2 ethambutol
embB 4247875 c.1362G>C synonymous_variant 0.19 ethambutol
embB 4247876 c.1363C>T synonymous_variant 0.19 ethambutol
embB 4247881 c.1368G>C synonymous_variant 0.17 ethambutol
embB 4247887 c.1374C>T synonymous_variant 0.17 ethambutol Not assoc w R - Interim
embB 4247893 c.1380C>T synonymous_variant 0.17 ethambutol
embB 4247899 p.Met462Ile missense_variant 0.17 ethambutol
embB 4247905 c.1392G>C synonymous_variant 0.18 ethambutol Not assoc w R - Interim
embB 4247909 c.1396T>C synonymous_variant 0.19 ethambutol
embB 4247914 c.1401G>C synonymous_variant 0.19 ethambutol Not assoc w R - Interim
embB 4247932 c.1419C>G synonymous_variant 0.19 ethambutol
embB 4247940 p.Leu476Trp missense_variant 0.16 ethambutol
embB 4247945 c.1432T>C synonymous_variant 0.16 ethambutol
embB 4247951 p.Ser480Ala missense_variant 0.16 ethambutol
embB 4247956 c.1443G>C synonymous_variant 0.15 ethambutol Not assoc w R - Interim
embB 4248035 p.Val508Ile missense_variant 0.14 ethambutol
embB 4248070 c.1557T>C synonymous_variant 0.14 ethambutol
embB 4248085 c.1572T>C synonymous_variant 0.16 ethambutol
embB 4248097 c.1584C>G synonymous_variant 0.17 ethambutol
embB 4248130 c.1617G>C synonymous_variant 0.22 ethambutol
embB 4248142 c.1629T>C synonymous_variant 0.22 ethambutol
embB 4248143 c.1630T>C synonymous_variant 0.22 ethambutol
embB 4248157 c.1644A>G synonymous_variant 0.2 ethambutol Not assoc w R - Interim
embB 4248172 c.1659G>C synonymous_variant 0.2 ethambutol
embB 4248199 c.1686A>G synonymous_variant 0.21 ethambutol
embB 4248200 p.Ile563Val missense_variant 0.21 ethambutol
embB 4248205 c.1692C>G synonymous_variant 0.21 ethambutol
embB 4248206 p.Ser565Gly missense_variant 0.21 ethambutol Uncertain significance
embB 4248220 c.1707A>C synonymous_variant 0.22 ethambutol
aftB 4267647 p.Asp397Gly missense_variant 1.0 ethambutol Not assoc w R
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 kanamycin
capreomycin
amikacin
gid 4407588 c.615A>G synonymous_variant 1.0 streptomycin Not assoc w R
gid 4407624 c.579G>C synonymous_variant 1.0 streptomycin Not assoc w R - Interim
gid 4407847 p.Ala119Asp missense_variant 1.0 streptomycin Uncertain significance
gid 4407927 p.Glu92Asp missense_variant 1.0 streptomycin Not assoc w R