Run ID: ERR2514552
Sample name:
Date: 2024-04-14T23:32:48.397277
Number of reads: 664645
Percentage reads mapped: 57.77
Median coverage: 20.0
Strain: lineage3
Spoligotype:
Drug-resistance: Sensitive
Lineage | Family | RDs | Frequency |
---|---|---|---|
lineage3 | East-African-Indian | RD750 | 1.0 |
Drug | Resistance | Supporting mutations | WHO confidence | Comment |
---|---|---|---|---|
rifampicin | ||||
isoniazid | ||||
ethambutol | ||||
pyrazinamide | ||||
streptomycin | ||||
fluoroquinolones | ||||
moxifloxacin | ||||
ofloxacin | ||||
levofloxacin | ||||
ciprofloxacin | ||||
aminoglycosides | ||||
amikacin | ||||
capreomycin | ||||
kanamycin | ||||
cycloserine | ||||
ethionamide | ||||
clofazimine | ||||
para-aminosalicylic_acid | ||||
delamanid | ||||
bedaquiline | ||||
linezolid |
Gene | Chromosome position | Mutation | Type | Estimated fraction | Drugs | Confidence | Comment |
---|
Gene | Chromosome position | Mutation | Type | Estimated fraction | Drugs | Confidence |
---|---|---|---|---|---|---|
dnaA | 693 | c.693A>C | synonymous_variant | 0.22 | isoniazid | |
dnaA | 705 | c.705A>G | synonymous_variant | 0.22 | isoniazid | |
dnaA | 708 | c.708T>C | synonymous_variant | 0.25 | isoniazid | |
dnaA | 720 | c.720G>A | synonymous_variant | 0.34 | isoniazid | |
dnaA | 741 | c.741T>C | synonymous_variant | 0.35 | isoniazid | Not assoc w R - Interim |
dnaA | 747 | c.747G>T | synonymous_variant | 0.36 | isoniazid | |
dnaA | 748 | c.748_750delCTCinsTG | frameshift_variant&missense_variant | 0.4 | isoniazid | Uncertain significance |
dnaA | 763 | p.Lys255Arg | missense_variant | 0.38 | isoniazid | |
dnaA | 771 | c.771A>G | synonymous_variant | 0.4 | isoniazid | |
dnaA | 793 | c.793_795delGTAinsAC | frameshift_variant&missense_variant | 0.39 | isoniazid | Uncertain significance |
dnaA | 801 | c.801G>T | synonymous_variant | 0.36 | isoniazid | |
dnaA | 804 | c.804G>C | synonymous_variant | 0.36 | isoniazid | |
dnaA | 805 | c.805_807delTTGinsCC | frameshift_variant&missense_variant | 0.38 | isoniazid | Uncertain significance |
dnaA | 822 | c.822A>G | synonymous_variant | 0.38 | isoniazid | |
dnaA | 828 | c.828T>C | synonymous_variant | 0.39 | isoniazid | Not assoc w R - Interim |
dnaA | 837 | c.837A>G | synonymous_variant | 0.33 | isoniazid | |
dnaA | 840 | c.840G>A | synonymous_variant | 0.32 | isoniazid | |
dnaA | 846 | c.846T>C | synonymous_variant | 0.31 | isoniazid | |
dnaA | 849 | c.849A>G | synonymous_variant | 0.31 | isoniazid | |
dnaA | 852 | c.852G>A | synonymous_variant | 0.33 | isoniazid | Not assoc w R - Interim |
gyrA | 7066 | c.-236G>T | upstream_gene_variant | 0.19 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7081 | c.-221T>C | upstream_gene_variant | 0.24 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7084 | c.-218A>G | upstream_gene_variant | 0.28 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7090 | c.-212C>T | upstream_gene_variant | 0.31 | levofloxacin | |
moxifloxacin | ||||||
gyrB | 7093 | c.1854T>C | synonymous_variant | 0.3 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrB | 7100 | c.1861T>C | synonymous_variant | 0.39 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 7123 | c.-179C>G | upstream_gene_variant | 0.36 | levofloxacin | |
moxifloxacin | ||||||
gyrB | 7126 | c.1887G>C | synonymous_variant | 0.33 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 7129 | c.-173T>G | upstream_gene_variant | 0.32 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7132 | c.-170T>C | upstream_gene_variant | 0.33 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7135 | c.-167G>A | upstream_gene_variant | 0.33 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7136 | c.-166T>C | upstream_gene_variant | 0.35 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7141 | c.-161T>G | upstream_gene_variant | 0.37 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7144 | c.-158A>G | upstream_gene_variant | 0.37 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7150 | c.-152G>A | upstream_gene_variant | 0.39 | levofloxacin | |
moxifloxacin | ||||||
gyrB | 7153 | c.1914G>C | synonymous_variant | 0.38 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 7168 | c.-134C>G | upstream_gene_variant | 0.37 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7178 | c.-124T>C | upstream_gene_variant | 0.39 | levofloxacin | |
moxifloxacin | ||||||
gyrB | 7186 | c.1947C>G | synonymous_variant | 0.37 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 7189 | c.-113C>T | upstream_gene_variant | 0.32 | levofloxacin | |
moxifloxacin | ||||||
gyrB | 7198 | c.1959C>T | synonymous_variant | 0.3 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | ||||||
gyrB | 7210 | p.Asp657Glu | missense_variant | 0.24 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7362 | p.Glu21Gln | missense_variant | 1.0 | levofloxacin | Not assoc w R |
moxifloxacin | Not assoc w R | |||||
gyrA | 7585 | p.Ser95Thr | missense_variant | 1.0 | levofloxacin | Not assoc w R |
moxifloxacin | Not assoc w R | |||||
gyrA | 7607 | c.306C>T | synonymous_variant | 0.25 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 8870 | c.1569G>C | synonymous_variant | 0.34 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 8873 | c.1572A>G | synonymous_variant | 0.34 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 8897 | c.1596T>C | synonymous_variant | 0.27 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 8903 | c.1602T>C | synonymous_variant | 0.28 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 8915 | c.1614A>G | synonymous_variant | 0.24 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 8924 | c.1623C>T | synonymous_variant | 0.23 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8942 | c.1641G>C | synonymous_variant | 0.19 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 9304 | p.Gly668Asp | missense_variant | 1.0 | levofloxacin | Not assoc w R |
moxifloxacin | Not assoc w R | |||||
Rv0565c | 657081 | c.390G>A | synonymous_variant | 1.0 | ethionamide | Not assoc w R - Interim |
hadA | 732145 | c.216C>T | synonymous_variant | 1.0 | isoniazid | Not assoc w R |
rpoB | 759746 | c.-61C>T | upstream_gene_variant | 1.0 | rifampicin | Not assoc w R |
rpoB | 760522 | p.Ser239Asn | missense_variant | 0.48 | rifampicin | Uncertain significance |
rpoB | 760532 | c.726T>C | synonymous_variant | 0.48 | rifampicin | Not assoc w R - Interim |
rpoB | 760541 | c.735G>C | synonymous_variant | 0.48 | rifampicin | Not assoc w R - Interim |
rpoB | 760553 | c.747C>G | synonymous_variant | 0.52 | rifampicin | |
rpoB | 760561 | c.757_758delCG | frameshift_variant | 0.37 | rifampicin | |
rpoB | 760567 | p.Ser254Trp | missense_variant | 0.36 | rifampicin | |
rpoB | 760568 | c.762_763insGC | frameshift_variant | 0.36 | rifampicin | |
rpoB | 760571 | c.765G>C | synonymous_variant | 0.34 | rifampicin | |
rpoB | 760588 | p.Thr261Ile | missense_variant | 0.36 | rifampicin | |
rpoB | 760591 | p.Val262Ala | missense_variant | 0.36 | rifampicin | |
rpoB | 760595 | c.789C>T | synonymous_variant | 0.36 | rifampicin | |
rpoB | 760596 | p.Thr264Pro | missense_variant | 0.38 | rifampicin | |
rpoB | 760608 | c.802C>T | synonymous_variant | 0.39 | rifampicin | Not assoc w R - Interim |
rpoB | 760611 | c.805T>C | synonymous_variant | 0.37 | rifampicin | Not assoc w R - Interim |
rpoB | 760634 | c.828T>C | synonymous_variant | 0.39 | rifampicin | Not assoc w R - Interim |
rpoB | 760646 | c.840C>G | synonymous_variant | 0.33 | rifampicin | Not assoc w R - Interim |
rpoB | 760655 | c.849A>G | synonymous_variant | 0.27 | rifampicin | Not assoc w R - Interim |
rpoB | 761051 | c.1245G>T | synonymous_variant | 0.3 | rifampicin | Not assoc w R - Interim |
rpoB | 761054 | c.1248G>C | synonymous_variant | 0.3 | rifampicin | Not assoc w R - Interim |
rpoB | 761060 | c.1254C>G | synonymous_variant | 0.29 | rifampicin | Not assoc w R - Interim |
rpoB | 761063 | c.1257C>G | synonymous_variant | 0.29 | rifampicin | Not assoc w R - Interim |
rpoB | 761084 | c.1278C>A | synonymous_variant | 0.4 | rifampicin | Not assoc w R - Interim |
rpoB | 761097 | c.1291_1293delAGCinsTCG | synonymous_variant | 0.36 | rifampicin | |
rpoB | 761102 | c.1296A>G | synonymous_variant | 0.36 | rifampicin | |
rpoB | 761132 | c.1326G>T | synonymous_variant | 0.3 | rifampicin | Not assoc w R - Interim |
rpoB | 761133 | c.1327T>C | synonymous_variant | 0.31 | rifampicin | Not assoc w R - Interim |
rpoB | 761537 | c.1731C>G | synonymous_variant | 0.25 | rifampicin | Not assoc w R - Interim |
rpoB | 761555 | c.1749G>C | synonymous_variant | 0.28 | rifampicin | Not assoc w R - Interim |
rpoB | 761558 | c.1752C>G | synonymous_variant | 0.27 | rifampicin | Not assoc w R - Interim |
rpoB | 761564 | c.1758G>C | synonymous_variant | 0.31 | rifampicin | Not assoc w R - Interim |
rpoB | 761573 | c.1767C>G | synonymous_variant | 0.31 | rifampicin | Not assoc w R - Interim |
rpoB | 761579 | c.1773G>C | synonymous_variant | 0.32 | rifampicin | Not assoc w R - Interim |
rpoB | 761606 | c.1800C>G | synonymous_variant | 0.31 | rifampicin | |
rpoB | 761612 | c.1806G>T | synonymous_variant | 0.37 | rifampicin | Not assoc w R - Interim |
rpoB | 761615 | c.1809A>C | synonymous_variant | 0.39 | rifampicin | Not assoc w R - Interim |
rpoB | 761636 | c.1830G>T | synonymous_variant | 0.46 | rifampicin | Not assoc w R - Interim |
rpoB | 761645 | c.1839C>G | synonymous_variant | 0.41 | rifampicin | Not assoc w R - Interim |
rpoB | 761648 | c.1842T>C | synonymous_variant | 0.41 | rifampicin | |
rpoB | 761657 | c.1851C>T | synonymous_variant | 0.41 | rifampicin | Not assoc w R - Interim |
rpoB | 761669 | c.1863C>T | synonymous_variant | 0.35 | rifampicin | |
rpoB | 761675 | c.1869G>C | synonymous_variant | 0.27 | rifampicin | |
rpoB | 761705 | c.1899C>A | synonymous_variant | 0.24 | rifampicin | Not assoc w R - Interim |
rpoB | 762086 | c.2280G>C | synonymous_variant | 0.36 | rifampicin | Not assoc w R - Interim |
rpoB | 762101 | c.2295C>G | synonymous_variant | 0.41 | rifampicin | Not assoc w R - Interim |
rpoB | 762114 | p.Ile770Val | missense_variant | 0.41 | rifampicin | Uncertain significance |
rpoB | 762176 | c.2370T>C | synonymous_variant | 0.36 | rifampicin | Not assoc w R - Interim |
rpoB | 762185 | c.2379G>C | synonymous_variant | 0.33 | rifampicin | Not assoc w R - Interim |
rpoB | 762194 | c.2388G>C | synonymous_variant | 0.29 | rifampicin | Not assoc w R - Interim |
rpoB | 762233 | c.2427G>C | synonymous_variant | 0.29 | rifampicin | Not assoc w R - Interim |
rpoB | 762434 | c.2628T>G | synonymous_variant | 0.8 | rifampicin | Not assoc w R |
rpoB | 762894 | c.3088C>T | synonymous_variant | 0.21 | rifampicin | Not assoc w R - Interim |
rpoB | 762899 | c.3093G>C | synonymous_variant | 0.29 | rifampicin | Not assoc w R - Interim |
rpoB | 762917 | c.3111C>G | synonymous_variant | 0.3 | rifampicin | Not assoc w R - Interim |
rpoB | 762920 | c.3114C>T | synonymous_variant | 0.29 | rifampicin | Not assoc w R - Interim |
rpoB | 762923 | c.3117C>G | synonymous_variant | 0.28 | rifampicin | Not assoc w R - Interim |
rpoB | 762929 | c.3123G>C | synonymous_variant | 0.31 | rifampicin | Not assoc w R - Interim |
rpoB | 762959 | c.3153G>C | synonymous_variant | 0.4 | rifampicin | Not assoc w R - Interim |
rpoB | 762962 | c.3156C>T | synonymous_variant | 0.4 | rifampicin | Not assoc w R - Interim |
rpoB | 763031 | c.3225T>C | synonymous_variant | 0.72 | rifampicin | Not assoc w R |
rpoC | 763468 | c.99G>C | synonymous_variant | 0.24 | rifampicin | Not assoc w R - Interim |
rpoC | 763486 | c.117T>C | synonymous_variant | 0.29 | rifampicin | Not assoc w R - Interim |
rpoC | 763492 | c.123G>C | synonymous_variant | 0.33 | rifampicin | Not assoc w R - Interim |
rpoC | 763528 | c.159G>A | synonymous_variant | 0.37 | rifampicin | Not assoc w R - Interim |
rpoC | 763531 | c.162G>T | synonymous_variant | 0.38 | rifampicin | Not assoc w R - Interim |
rpoC | 763546 | c.177A>G | synonymous_variant | 0.34 | rifampicin | Not assoc w R - Interim |
rpoC | 763570 | c.201G>C | synonymous_variant | 0.36 | rifampicin | Not assoc w R - Interim |
rpoC | 763594 | c.225C>T | synonymous_variant | 0.36 | rifampicin | Not assoc w R - Interim |
rpoC | 763609 | c.240C>T | synonymous_variant | 0.37 | rifampicin | |
rpoC | 763621 | c.252C>T | synonymous_variant | 0.32 | rifampicin | |
rpoC | 763633 | c.264T>C | synonymous_variant | 0.32 | rifampicin | Not assoc w R - Interim |
rpoC | 764509 | c.1140G>A | synonymous_variant | 0.32 | rifampicin | |
rpoC | 764510 | c.1141C>T | synonymous_variant | 0.32 | rifampicin | Not assoc w R - Interim |
rpoC | 764521 | c.1152T>C | synonymous_variant | 0.32 | rifampicin | Not assoc w R - Interim |
rpoC | 764527 | c.1158C>T | synonymous_variant | 0.32 | rifampicin | Not assoc w R - Interim |
rpoC | 764530 | c.1161C>T | synonymous_variant | 0.35 | rifampicin | Not assoc w R - Interim |
rpoC | 764533 | c.1164C>A | synonymous_variant | 0.33 | rifampicin | Not assoc w R - Interim |
rpoC | 764536 | c.1167G>T | synonymous_variant | 0.32 | rifampicin | Not assoc w R - Interim |
rpoC | 764539 | c.1170C>G | synonymous_variant | 0.32 | rifampicin | Not assoc w R - Interim |
rpoC | 764545 | c.1176C>A | synonymous_variant | 0.37 | rifampicin | Not assoc w R - Interim |
rpoC | 764575 | c.1206T>G | synonymous_variant | 0.42 | rifampicin | Not assoc w R - Interim |
rpoC | 764593 | c.1224C>T | synonymous_variant | 0.39 | rifampicin | |
rpoC | 764611 | c.1242G>T | synonymous_variant | 0.41 | rifampicin | Not assoc w R - Interim |
rpoC | 764626 | c.1257C>T | synonymous_variant | 0.36 | rifampicin | Not assoc w R - Interim |
rpoC | 764632 | c.1263T>C | synonymous_variant | 0.37 | rifampicin | Not assoc w R - Interim |
rpoC | 764650 | c.1281G>T | synonymous_variant | 0.43 | rifampicin | Not assoc w R - Interim |
rpoC | 764668 | c.1299C>T | synonymous_variant | 0.42 | rifampicin | Not assoc w R - Interim |
rpoC | 764683 | c.1314G>A | synonymous_variant | 0.45 | rifampicin | |
rpoC | 764692 | c.1323C>T | synonymous_variant | 0.45 | rifampicin | Not assoc w R - Interim |
rpoC | 764713 | c.1344G>T | synonymous_variant | 0.37 | rifampicin | Not assoc w R - Interim |
rpoC | 764716 | c.1347G>C | synonymous_variant | 0.37 | rifampicin | Not assoc w R - Interim |
rpoC | 764746 | c.1377G>T | synonymous_variant | 0.27 | rifampicin | Not assoc w R - Interim |
rpoC | 764752 | c.1383G>C | synonymous_variant | 0.27 | rifampicin | Not assoc w R - Interim |
rpoC | 764758 | c.1389C>G | synonymous_variant | 0.27 | rifampicin | Not assoc w R - Interim |
rpoC | 764764 | c.1395T>C | synonymous_variant | 0.27 | rifampicin | Not assoc w R - Interim |
rpoC | 764791 | c.1422C>G | synonymous_variant | 0.26 | rifampicin | Not assoc w R - Interim |
rpoC | 764803 | c.1434C>T | synonymous_variant | 0.19 | rifampicin | Not assoc w R - Interim |
rpoC | 764809 | c.1440C>T | synonymous_variant | 0.19 | rifampicin | Not assoc w R |
rpoC | 764810 | p.Pro481Ala | missense_variant | 0.21 | rifampicin | Uncertain significance |
rpoC | 764815 | c.1446A>G | synonymous_variant | 0.21 | rifampicin | Not assoc w R - Interim |
rpoC | 764824 | c.1455T>C | synonymous_variant | 0.23 | rifampicin | Not assoc w R - Interim |
rpoC | 764827 | c.1458G>C | synonymous_variant | 0.24 | rifampicin | Not assoc w R - Interim |
rpoC | 764858 | c.1489T>C | synonymous_variant | 0.3 | rifampicin | Not assoc w R - Interim |
rpoC | 764869 | c.1500C>T | synonymous_variant | 0.29 | rifampicin | Not assoc w R - Interim |
rpoC | 764875 | c.1506C>A | synonymous_variant | 0.29 | rifampicin | Not assoc w R - Interim |
rpoC | 764887 | c.1518G>C | synonymous_variant | 0.23 | rifampicin | Not assoc w R - Interim |
rpoC | 764888 | c.1519T>C | synonymous_variant | 0.23 | rifampicin | Not assoc w R - Interim |
rpoC | 764911 | c.1542A>G | synonymous_variant | 0.2 | rifampicin | |
rpoC | 764912 | p.Met515Gln | missense_variant | 0.2 | rifampicin | Uncertain significance |
rpoC | 764932 | c.1563C>A | synonymous_variant | 0.23 | rifampicin | Not assoc w R - Interim |
rpoC | 764968 | c.1599T>C | synonymous_variant | 0.25 | rifampicin | Not assoc w R - Interim |
rpoC | 765383 | p.Met672Leu | missense_variant | 0.32 | rifampicin | Uncertain significance |
rpoC | 765403 | c.2034G>C | synonymous_variant | 0.44 | rifampicin | |
rpoC | 765405 | p.Leu679His | missense_variant | 0.44 | rifampicin | Uncertain significance |
rpoC | 765409 | c.2040T>G | synonymous_variant | 0.4 | rifampicin | Not assoc w R - Interim |
rpoC | 765421 | c.2052C>G | synonymous_variant | 0.41 | rifampicin | Not assoc w R - Interim |
rpoC | 765449 | c.2080_2082delGCCinsTG | frameshift_variant&missense_variant | 0.42 | rifampicin | |
rpoC | 765454 | c.2085C>G | synonymous_variant | 0.43 | rifampicin | Not assoc w R - Interim |
rpoC | 765469 | c.2100G>C | synonymous_variant | 0.42 | rifampicin | Not assoc w R - Interim |
rpoC | 765478 | c.2109T>G | synonymous_variant | 0.4 | rifampicin | |
rpoC | 765480 | p.Tyr704Phe | missense_variant | 0.38 | rifampicin | Uncertain significance |
rpoC | 765499 | c.2130C>G | synonymous_variant | 0.3 | rifampicin | Not assoc w R - Interim |
rpoC | 766570 | c.3201T>C | synonymous_variant | 0.33 | rifampicin | |
rpoC | 766573 | c.3204T>G | synonymous_variant | 0.33 | rifampicin | Not assoc w R - Interim |
rpoC | 766594 | c.3225G>T | synonymous_variant | 0.33 | rifampicin | |
rpoC | 766607 | p.Ile1080Leu | missense_variant | 0.38 | rifampicin | |
rpoC | 766618 | c.3249G>T | synonymous_variant | 0.31 | rifampicin | |
rpoC | 766624 | c.3255G>C | synonymous_variant | 0.32 | rifampicin | |
rpoC | 766630 | c.3261G>C | synonymous_variant | 0.32 | rifampicin | |
rpoC | 766633 | c.3264G>C | synonymous_variant | 0.31 | rifampicin | |
rpoC | 766642 | c.3273C>T | synonymous_variant | 0.3 | rifampicin | |
rpoC | 766645 | c.3276A>G | synonymous_variant | 0.28 | rifampicin | |
rpoC | 766651 | c.3282T>C | synonymous_variant | 0.23 | rifampicin | |
mmpL5 | 775639 | p.Ile948Val | missense_variant | 1.0 | clofazimine | Not assoc w R |
bedaquiline | Not assoc w R - Interim | |||||
mmpL5 | 776100 | p.Thr794Ile | missense_variant | 1.0 | clofazimine | Not assoc w R |
bedaquiline | Not assoc w R - Interim | |||||
rpsL | 781395 | c.-165T>C | upstream_gene_variant | 1.0 | streptomycin | Not assoc w R |
rpsL | 781706 | c.147T>C | synonymous_variant | 0.24 | streptomycin | |
rpsL | 781802 | c.243G>C | synonymous_variant | 0.27 | streptomycin | |
rpsL | 781814 | c.255C>T | synonymous_variant | 0.31 | streptomycin | |
rpsL | 781817 | c.258G>T | synonymous_variant | 0.31 | streptomycin | |
rpsL | 781829 | c.270G>C | synonymous_variant | 0.3 | streptomycin | |
rpsL | 781832 | c.273T>C | synonymous_variant | 0.3 | streptomycin | |
rpsL | 781859 | c.300T>C | synonymous_variant | 0.34 | streptomycin | Not assoc w R - Interim |
rpsL | 781868 | c.309T>C | synonymous_variant | 0.34 | streptomycin | |
rpsL | 781871 | c.312G>C | synonymous_variant | 0.31 | streptomycin | |
rpsL | 781877 | c.318T>A | synonymous_variant | 0.28 | streptomycin | |
rpsL | 781892 | c.333A>G | synonymous_variant | 0.3 | streptomycin | |
rpsL | 781898 | c.339A>T | synonymous_variant | 0.3 | streptomycin | |
rpsL | 781907 | c.348T>C | synonymous_variant | 0.31 | streptomycin | |
rpsL | 781916 | c.357T>C | synonymous_variant | 0.31 | streptomycin | |
rpsL | 781929 | p.Gly124Ser | missense_variant | 0.26 | streptomycin | Uncertain significance |
rpsL | 781933 | c.374G>A | splice_region_variant&stop_retained_variant | 0.27 | streptomycin | |
Rv1129c | 1254562 | c.-28T>C | upstream_gene_variant | 1.0 | moxifloxacin | Not assoc w R |
levofloxacin | Not assoc w R | |||||
rifampicin | Not assoc w R | |||||
isoniazid | Not assoc w R | |||||
sigE | 1364703 | c.291G>C | synonymous_variant | 0.19 | pyrazinamide | |
sigE | 1364709 | c.297T>G | synonymous_variant | 0.18 | pyrazinamide | |
sigE | 1364712 | c.300T>C | synonymous_variant | 0.18 | pyrazinamide | |
sigE | 1364718 | c.306C>T | synonymous_variant | 0.2 | pyrazinamide | |
sigE | 1364726 | p.Asn105Ser | missense_variant | 0.2 | pyrazinamide | |
atpE | 1461149 | c.105T>G | synonymous_variant | 0.5 | bedaquiline | |
atpE | 1461161 | c.117C>G | synonymous_variant | 0.47 | bedaquiline | |
atpE | 1461164 | c.120C>T | synonymous_variant | 0.45 | bedaquiline | |
atpE | 1461167 | c.123G>T | synonymous_variant | 0.45 | bedaquiline | |
atpE | 1461170 | c.126A>G | synonymous_variant | 0.45 | bedaquiline | |
atpE | 1461179 | c.135G>T | synonymous_variant | 0.45 | bedaquiline | |
atpE | 1461182 | c.138A>G | synonymous_variant | 0.43 | bedaquiline | |
atpE | 1461185 | c.141G>C | synonymous_variant | 0.41 | bedaquiline | |
atpE | 1461197 | c.153A>C | synonymous_variant | 0.39 | bedaquiline | |
atpE | 1461219 | c.175T>C | synonymous_variant | 0.39 | bedaquiline | |
rrs | 1471659 | n.-187C>T | upstream_gene_variant | 1.0 | streptomycin | |
kanamycin | ||||||
capreomycin | ||||||
amikacin | ||||||
rpsA | 1833619 | c.78A>C | synonymous_variant | 0.33 | pyrazinamide | |
rpsA | 1833625 | c.84A>G | synonymous_variant | 0.32 | pyrazinamide | |
rpsA | 1833664 | c.123C>G | synonymous_variant | 0.37 | pyrazinamide | |
rpsA | 1833676 | c.135A>G | synonymous_variant | 0.33 | pyrazinamide | |
rpsA | 1833679 | c.138G>T | synonymous_variant | 0.33 | pyrazinamide | |
rpsA | 1833685 | c.144G>C | synonymous_variant | 0.35 | pyrazinamide | |
rpsA | 1833691 | c.150G>A | synonymous_variant | 0.31 | pyrazinamide | |
rpsA | 1833760 | c.219C>T | synonymous_variant | 0.38 | pyrazinamide | Not assoc w R - Interim |
rpsA | 1833787 | c.246C>G | synonymous_variant | 0.31 | pyrazinamide | |
rpsA | 1833790 | c.249T>C | synonymous_variant | 0.31 | pyrazinamide | |
rpsA | 1833802 | c.261A>G | synonymous_variant | 0.31 | pyrazinamide | |
rpsA | 1833811 | c.270G>T | synonymous_variant | 0.32 | pyrazinamide | |
rpsA | 1833823 | c.282G>A | synonymous_variant | 0.33 | pyrazinamide | |
rpsA | 1833832 | c.291G>A | synonymous_variant | 0.34 | pyrazinamide | |
rpsA | 1833835 | c.294C>T | synonymous_variant | 0.34 | pyrazinamide | |
rpsA | 1833838 | c.297G>C | synonymous_variant | 0.34 | pyrazinamide | |
rpsA | 1833841 | c.300C>G | synonymous_variant | 0.35 | pyrazinamide | |
rpsA | 1833847 | c.306C>G | synonymous_variant | 0.36 | pyrazinamide | |
rpsA | 1833862 | c.321G>T | synonymous_variant | 0.42 | pyrazinamide | |
rpsA | 1833874 | c.333T>G | synonymous_variant | 0.41 | pyrazinamide | |
rpsA | 1833877 | c.336C>G | synonymous_variant | 0.41 | pyrazinamide | |
rpsA | 1833886 | c.345C>G | synonymous_variant | 0.42 | pyrazinamide | |
rpsA | 1833894 | p.Ala118Glu | missense_variant | 0.42 | pyrazinamide | |
rpsA | 1833928 | c.387G>C | synonymous_variant | 0.41 | pyrazinamide | |
rpsA | 1833949 | c.408T>C | synonymous_variant | 0.5 | pyrazinamide | |
rpsA | 1833958 | c.417C>T | synonymous_variant | 0.47 | pyrazinamide | |
rpsA | 1833961 | c.420C>G | synonymous_variant | 0.47 | pyrazinamide | |
rpsA | 1833970 | c.429G>T | synonymous_variant | 0.5 | pyrazinamide | |
rpsA | 1833979 | c.438T>C | synonymous_variant | 0.55 | pyrazinamide | |
rpsA | 1833991 | c.450C>G | synonymous_variant | 0.55 | pyrazinamide | |
rpsA | 1834000 | c.459G>C | synonymous_variant | 0.52 | pyrazinamide | |
rpsA | 1834009 | c.468C>T | synonymous_variant | 0.46 | pyrazinamide | |
rpsA | 1834012 | c.471G>C | synonymous_variant | 0.48 | pyrazinamide | |
rpsA | 1834015 | c.474G>C | synonymous_variant | 0.48 | pyrazinamide | |
rpsA | 1834021 | c.480C>T | synonymous_variant | 0.47 | pyrazinamide | |
rpsA | 1834030 | c.489C>G | synonymous_variant | 0.46 | pyrazinamide | |
rpsA | 1834073 | p.Lys178Arg | missense_variant | 0.34 | pyrazinamide | |
rpsA | 1834096 | c.555G>C | synonymous_variant | 0.24 | pyrazinamide | |
rpsA | 1834099 | c.558C>G | synonymous_variant | 0.23 | pyrazinamide | |
rpsA | 1834240 | c.699T>C | synonymous_variant | 0.24 | pyrazinamide | |
rpsA | 1834246 | c.705G>T | synonymous_variant | 0.24 | pyrazinamide | |
rpsA | 1834249 | c.708T>C | synonymous_variant | 0.25 | pyrazinamide | |
rpsA | 1834252 | c.711C>G | synonymous_variant | 0.26 | pyrazinamide | |
rpsA | 1834261 | c.720A>G | synonymous_variant | 0.32 | pyrazinamide | Not assoc w R - Interim |
rpsA | 1834264 | c.723G>C | synonymous_variant | 0.32 | pyrazinamide | |
rpsA | 1834303 | c.762T>G | synonymous_variant | 0.32 | pyrazinamide | |
rpsA | 1834306 | c.765T>C | synonymous_variant | 0.33 | pyrazinamide | |
rpsA | 1834438 | c.897C>T | synonymous_variant | 0.25 | pyrazinamide | Not assoc w R - Interim |
rpsA | 1834451 | c.910T>C | synonymous_variant | 0.33 | pyrazinamide | |
rpsA | 1834456 | c.915T>G | synonymous_variant | 0.38 | pyrazinamide | |
rpsA | 1834468 | c.927A>G | synonymous_variant | 0.44 | pyrazinamide | |
rpsA | 1834477 | c.936C>T | synonymous_variant | 0.44 | pyrazinamide | Not assoc w R - Interim |
rpsA | 1834489 | c.948T>C | synonymous_variant | 0.48 | pyrazinamide | |
rpsA | 1834516 | c.975G>A | synonymous_variant | 0.52 | pyrazinamide | |
rpsA | 1834519 | c.978G>C | synonymous_variant | 0.57 | pyrazinamide | |
rpsA | 1834520 | c.979_981delGCCinsTG | frameshift_variant&missense_variant | 0.57 | pyrazinamide | Uncertain significance |
rpsA | 1834528 | c.987T>C | synonymous_variant | 0.54 | pyrazinamide | |
rpsA | 1834543 | c.1002C>G | synonymous_variant | 0.52 | pyrazinamide | |
rpsA | 1834546 | c.1005T>C | synonymous_variant | 0.5 | pyrazinamide | |
rpsA | 1834552 | c.1011G>T | synonymous_variant | 0.5 | pyrazinamide | |
rpsA | 1834555 | c.1014T>G | synonymous_variant | 0.48 | pyrazinamide | |
rpsA | 1834557 | p.Ala339Gly | missense_variant | 0.48 | pyrazinamide | |
rpsA | 1834606 | c.1065C>T | synonymous_variant | 0.48 | pyrazinamide | |
rpsA | 1834609 | c.1068T>C | synonymous_variant | 0.43 | pyrazinamide | |
rpsA | 1834619 | c.1078T>C | synonymous_variant | 0.4 | pyrazinamide | |
rpsA | 1834622 | c.1081_1083delTCGinsAGC | synonymous_variant | 0.42 | pyrazinamide | |
rpsA | 1834633 | c.1092A>G | synonymous_variant | 0.42 | pyrazinamide | |
rpsA | 1834639 | c.1098T>C | synonymous_variant | 0.33 | pyrazinamide | |
rpsA | 1834645 | c.1104C>T | synonymous_variant | 0.33 | pyrazinamide | |
tsnR | 1854300 | p.Leu232Pro | missense_variant | 1.0 | linezolid | Not assoc w R |
katG | 2154724 | p.Arg463Leu | missense_variant | 1.0 | isoniazid | Not assoc w R |
PPE35 | 2167926 | p.Leu896Ser | missense_variant | 1.0 | pyrazinamide | Not assoc w R |
Rv1979c | 2223293 | c.-129A>G | upstream_gene_variant | 1.0 | clofazimine | Not assoc w R |
bedaquiline | Not assoc w R - Interim | |||||
pncA | 2289047 | c.195C>T | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R |
pncA | 2289365 | c.-125delC | upstream_gene_variant | 1.0 | pyrazinamide | |
kasA | 2517917 | c.-198G>C | upstream_gene_variant | 0.63 | isoniazid | |
kasA | 2517941 | c.-174C>G | upstream_gene_variant | 0.61 | isoniazid | |
kasA | 2517953 | c.-162C>T | upstream_gene_variant | 0.6 | isoniazid | |
kasA | 2517962 | c.-153C>G | upstream_gene_variant | 0.52 | isoniazid | |
kasA | 2517968 | c.-147T>A | upstream_gene_variant | 0.55 | isoniazid | |
ahpC | 2726105 | c.-88G>A | upstream_gene_variant | 1.0 | isoniazid | Not assoc w R |
Rv2477c | 2782498 | c.1545C>T | synonymous_variant | 1.0 | ethambutol | Not assoc w R |
moxifloxacin | Not assoc w R | |||||
streptomycin | Not assoc w R - Interim | |||||
levofloxacin | Not assoc w R | |||||
kanamycin | Not assoc w R | |||||
rifampicin | Not assoc w R | |||||
amikacin | Not assoc w R | |||||
Rv2477c | 2783485 | c.558G>C | synonymous_variant | 0.33 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
kanamycin | ||||||
rifampicin | ||||||
amikacin | ||||||
Rv2477c | 2783491 | c.552C>T | synonymous_variant | 0.3 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
kanamycin | ||||||
rifampicin | ||||||
amikacin | ||||||
Rv2477c | 2783499 | c.544T>C | synonymous_variant | 0.27 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
kanamycin | ||||||
rifampicin | ||||||
amikacin | ||||||
Rv2477c | 2783502 | c.541T>C | synonymous_variant | 0.27 | ethambutol | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
streptomycin | Not assoc w R - Interim | |||||
levofloxacin | Not assoc w R - Interim | |||||
kanamycin | Not assoc w R - Interim | |||||
rifampicin | Not assoc w R - Interim | |||||
amikacin | Not assoc w R - Interim | |||||
Rv2477c | 2783509 | c.534C>A | synonymous_variant | 0.27 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
kanamycin | ||||||
rifampicin | ||||||
amikacin | ||||||
Rv2477c | 2783512 | c.531A>G | synonymous_variant | 0.26 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
kanamycin | ||||||
rifampicin | ||||||
amikacin | ||||||
Rv2477c | 2783515 | c.528C>G | synonymous_variant | 0.26 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
kanamycin | ||||||
rifampicin | ||||||
amikacin | ||||||
Rv2477c | 2783520 | c.523T>C | synonymous_variant | 0.24 | ethambutol | Not assoc w R - Interim |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
kanamycin | ||||||
rifampicin | Not assoc w R - Interim | |||||
amikacin | ||||||
Rv2477c | 2783523 | c.520C>T | synonymous_variant | 0.24 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
kanamycin | ||||||
rifampicin | ||||||
amikacin | ||||||
Rv2477c | 2783527 | c.516A>G | synonymous_variant | 0.24 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
kanamycin | ||||||
rifampicin | ||||||
amikacin | ||||||
Rv2477c | 2783548 | c.495T>C | synonymous_variant | 0.27 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
kanamycin | ||||||
rifampicin | ||||||
amikacin | ||||||
ald | 3086788 | c.-32T>C | upstream_gene_variant | 1.0 | cycloserine | |
mtrB | 3626717 | c.-104C>T | upstream_gene_variant | 0.26 | bedaquiline | |
rifampicin | ||||||
mtrB | 3626726 | c.-113T>C | upstream_gene_variant | 0.29 | bedaquiline | |
rifampicin | ||||||
mtrB | 3626732 | c.-119A>G | upstream_gene_variant | 0.28 | bedaquiline | |
rifampicin | ||||||
mtrA | 3626741 | c.609C>G | synonymous_variant | 0.26 | bedaquiline | |
rifampicin | Not assoc w R - Interim | |||||
mtrA | 3626756 | c.594C>G | synonymous_variant | 0.27 | bedaquiline | |
rifampicin | Not assoc w R - Interim | |||||
mtrA | 3626759 | c.591T>C | synonymous_variant | 0.27 | bedaquiline | |
rifampicin | Not assoc w R - Interim | |||||
mtrA | 3626762 | c.588G>C | synonymous_variant | 0.28 | bedaquiline | |
rifampicin | Not assoc w R - Interim | |||||
mtrA | 3626786 | c.564A>G | synonymous_variant | 0.36 | bedaquiline | |
rifampicin | Not assoc w R - Interim | |||||
mtrA | 3626792 | c.558G>T | synonymous_variant | 0.35 | bedaquiline | |
rifampicin | Not assoc w R - Interim | |||||
mtrA | 3626804 | c.546A>G | synonymous_variant | 0.29 | bedaquiline | |
rifampicin | Not assoc w R - Interim | |||||
mtrA | 3626825 | c.525T>A | synonymous_variant | 0.22 | bedaquiline | |
rifampicin | Not assoc w R - Interim | |||||
mtrA | 3627098 | c.252A>C | synonymous_variant | 0.35 | bedaquiline | |
rifampicin | Not assoc w R - Interim | |||||
mtrB | 3627110 | c.-497G>C | upstream_gene_variant | 0.35 | bedaquiline | |
rifampicin | ||||||
mtrA | 3627119 | c.231T>G | synonymous_variant | 0.32 | bedaquiline | |
rifampicin | Not assoc w R - Interim | |||||
mtrB | 3627122 | c.-509T>G | upstream_gene_variant | 0.32 | bedaquiline | |
rifampicin | ||||||
mtrB | 3627128 | c.-515T>C | upstream_gene_variant | 0.3 | bedaquiline | |
rifampicin | ||||||
mtrA | 3627133 | p.Ala73Ser | missense_variant | 0.3 | bedaquiline | |
rifampicin | ||||||
mtrB | 3627139 | c.-526T>C | upstream_gene_variant | 0.26 | bedaquiline | |
rifampicin | ||||||
mtrB | 3627143 | c.-530G>C | upstream_gene_variant | 0.26 | bedaquiline | |
rifampicin | ||||||
mtrB | 3627149 | c.-536G>A | upstream_gene_variant | 0.29 | bedaquiline | |
rifampicin | ||||||
rpoA | 3877587 | c.921A>G | synonymous_variant | 0.39 | rifampicin | Not assoc w R - Interim |
rpoA | 3877593 | c.915C>T | synonymous_variant | 0.39 | rifampicin | Not assoc w R - Interim |
rpoA | 3877614 | c.894G>A | synonymous_variant | 0.37 | rifampicin | Not assoc w R - Interim |
rpoA | 3877620 | c.888G>A | synonymous_variant | 0.39 | rifampicin | Not assoc w R - Interim |
rpoA | 3877638 | c.870T>C | synonymous_variant | 0.35 | rifampicin | Not assoc w R - Interim |
rpoA | 3877656 | c.852T>G | synonymous_variant | 0.38 | rifampicin | Not assoc w R - Interim |
rpoA | 3877665 | c.843C>G | synonymous_variant | 0.38 | rifampicin | Not assoc w R - Interim |
rpoA | 3877677 | c.831G>C | synonymous_variant | 0.39 | rifampicin | Not assoc w R - Interim |
rpoA | 3877680 | c.828G>C | synonymous_variant | 0.36 | rifampicin | Not assoc w R - Interim |
rpoA | 3877686 | c.822A>G | synonymous_variant | 0.36 | rifampicin | Not assoc w R - Interim |
rpoA | 3877692 | c.816G>C | synonymous_variant | 0.38 | rifampicin | Not assoc w R - Interim |
rpoA | 3877704 | c.804G>T | synonymous_variant | 0.4 | rifampicin | Not assoc w R - Interim |
rpoA | 3877737 | c.771G>C | synonymous_variant | 0.33 | rifampicin | |
rpoA | 3877743 | c.765T>C | synonymous_variant | 0.33 | rifampicin | Not assoc w R - Interim |
rpoA | 3877764 | c.744C>G | synonymous_variant | 0.35 | rifampicin | Not assoc w R - Interim |
rpoA | 3877770 | c.738A>G | synonymous_variant | 0.35 | rifampicin | Not assoc w R - Interim |
rpoA | 3877773 | c.735G>C | synonymous_variant | 0.35 | rifampicin | |
rpoA | 3877776 | c.732T>C | synonymous_variant | 0.33 | rifampicin | Not assoc w R - Interim |
rpoA | 3877782 | c.726T>C | synonymous_variant | 0.33 | rifampicin | Not assoc w R - Interim |
rpoA | 3877797 | c.711G>A | synonymous_variant | 0.27 | rifampicin | Not assoc w R - Interim |
rpoA | 3877848 | c.660C>T | synonymous_variant | 0.29 | rifampicin | Not assoc w R - Interim |
rpoA | 3877857 | c.651G>A | synonymous_variant | 0.21 | rifampicin | |
rpoA | 3877875 | c.633T>C | synonymous_variant | 0.24 | rifampicin | Not assoc w R - Interim |
rpoA | 3877905 | c.603A>G | synonymous_variant | 0.24 | rifampicin | Not assoc w R - Interim |
rpoA | 3877908 | c.600T>C | synonymous_variant | 0.24 | rifampicin | Not assoc w R - Interim |
rpoA | 3877920 | c.588G>C | synonymous_variant | 0.24 | rifampicin | Not assoc w R - Interim |
rpoA | 3878259 | c.249G>C | synonymous_variant | 0.57 | rifampicin | Not assoc w R - Interim |
rpoA | 3878271 | c.237T>C | synonymous_variant | 0.5 | rifampicin | Not assoc w R - Interim |
rpoA | 3878283 | p.Glu75Asp | missense_variant | 0.48 | rifampicin | Uncertain significance |
rpoA | 3878292 | c.216T>C | synonymous_variant | 0.41 | rifampicin | Not assoc w R - Interim |
rpoA | 3878298 | c.210A>G | synonymous_variant | 0.37 | rifampicin | Not assoc w R - Interim |
rpoA | 3878301 | c.207C>G | synonymous_variant | 0.37 | rifampicin | Not assoc w R - Interim |
rpoA | 3878310 | c.198G>T | synonymous_variant | 0.38 | rifampicin | Not assoc w R - Interim |
rpoA | 3878313 | c.195G>C | synonymous_variant | 0.38 | rifampicin | Not assoc w R - Interim |
rpoA | 3878322 | c.186A>G | synonymous_variant | 0.35 | rifampicin | Not assoc w R - Interim |
rpoA | 3878331 | c.177A>G | synonymous_variant | 0.31 | rifampicin | Not assoc w R - Interim |
rpoA | 3878337 | c.171T>C | synonymous_variant | 0.35 | rifampicin | Not assoc w R - Interim |
rpoA | 3878343 | c.165C>T | synonymous_variant | 0.38 | rifampicin | Not assoc w R - Interim |
rpoA | 3878346 | c.162T>C | synonymous_variant | 0.38 | rifampicin | |
rpoA | 3878364 | c.144A>C | synonymous_variant | 0.23 | rifampicin | |
rpoA | 3878367 | c.141C>G | synonymous_variant | 0.22 | rifampicin | |
rpoA | 3878373 | c.135G>C | synonymous_variant | 0.2 | rifampicin | |
clpC1 | 4038767 | c.1938G>T | synonymous_variant | 0.16 | pyrazinamide | |
clpC1 | 4038770 | c.1935C>T | synonymous_variant | 0.16 | pyrazinamide | |
clpC1 | 4038773 | c.1932T>C | synonymous_variant | 0.17 | pyrazinamide | |
clpC1 | 4038782 | c.1923G>T | synonymous_variant | 0.15 | pyrazinamide | |
clpC1 | 4038790 | c.1915C>T | synonymous_variant | 0.15 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4038795 | p.Ser637Thr | missense_variant | 0.14 | pyrazinamide | |
clpC1 | 4038812 | c.1893T>C | synonymous_variant | 0.14 | pyrazinamide | |
clpC1 | 4038815 | c.1890G>T | synonymous_variant | 0.14 | pyrazinamide | |
clpC1 | 4038842 | c.1863G>C | synonymous_variant | 0.14 | pyrazinamide | |
clpC1 | 4038845 | c.1858_1860delTCGinsAGC | synonymous_variant | 0.15 | pyrazinamide | |
clpC1 | 4038860 | c.1845G>T | synonymous_variant | 0.18 | pyrazinamide | |
clpC1 | 4038878 | c.1827A>G | synonymous_variant | 0.27 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4039094 | c.1611C>T | synonymous_variant | 0.44 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4039097 | c.1608G>T | synonymous_variant | 0.44 | pyrazinamide | |
clpC1 | 4039106 | c.1599G>C | synonymous_variant | 0.53 | pyrazinamide | |
clpC1 | 4039112 | c.1593C>G | synonymous_variant | 0.53 | pyrazinamide | |
clpC1 | 4039121 | c.1584T>C | synonymous_variant | 0.5 | pyrazinamide | |
clpC1 | 4039142 | c.1563A>G | synonymous_variant | 0.46 | pyrazinamide | |
clpC1 | 4039145 | c.1560G>C | synonymous_variant | 0.46 | pyrazinamide | |
clpC1 | 4039165 | c.1540C>T | synonymous_variant | 0.32 | pyrazinamide | |
clpC1 | 4039169 | p.Glu512Asp | missense_variant | 0.32 | pyrazinamide | |
clpC1 | 4039172 | c.1533A>G | synonymous_variant | 0.3 | pyrazinamide | |
clpC1 | 4039178 | c.1527G>C | synonymous_variant | 0.32 | pyrazinamide | |
clpC1 | 4039183 | c.1522T>C | synonymous_variant | 0.32 | pyrazinamide | |
clpC1 | 4039190 | c.1515C>T | synonymous_variant | 0.27 | pyrazinamide | |
clpC1 | 4039409 | c.1296T>C | synonymous_variant | 0.32 | pyrazinamide | |
clpC1 | 4039412 | c.1293T>G | synonymous_variant | 0.32 | pyrazinamide | |
clpC1 | 4039415 | p.Glu430Asp | missense_variant | 0.33 | pyrazinamide | Uncertain significance |
clpC1 | 4039472 | c.1233G>C | synonymous_variant | 0.33 | pyrazinamide | |
clpC1 | 4039478 | c.1227G>C | synonymous_variant | 0.32 | pyrazinamide | |
clpC1 | 4039481 | c.1224T>C | synonymous_variant | 0.38 | pyrazinamide | |
clpC1 | 4039487 | c.1218G>C | synonymous_variant | 0.38 | pyrazinamide | |
clpC1 | 4039522 | c.1183C>T | synonymous_variant | 0.47 | pyrazinamide | |
clpC1 | 4039528 | c.1177C>A | synonymous_variant | 0.5 | pyrazinamide | |
clpC1 | 4039541 | c.1164C>G | synonymous_variant | 0.56 | pyrazinamide | |
clpC1 | 4039544 | c.1161C>T | synonymous_variant | 0.57 | pyrazinamide | |
clpC1 | 4039556 | c.1149G>C | synonymous_variant | 0.52 | pyrazinamide | |
clpC1 | 4039559 | c.1146C>G | synonymous_variant | 0.52 | pyrazinamide | |
clpC1 | 4039565 | c.1140G>T | synonymous_variant | 0.48 | pyrazinamide | |
clpC1 | 4039570 | p.Met379Leu | missense_variant | 0.46 | pyrazinamide | Uncertain significance |
clpC1 | 4039574 | p.Ala377Gly | missense_variant | 0.44 | pyrazinamide | |
clpC1 | 4039586 | c.1119G>C | synonymous_variant | 0.46 | pyrazinamide | |
clpC1 | 4039601 | c.1104G>A | synonymous_variant | 0.45 | pyrazinamide | |
clpC1 | 4039610 | c.1095G>C | synonymous_variant | 0.45 | pyrazinamide | |
clpC1 | 4039616 | c.1089G>C | synonymous_variant | 0.45 | pyrazinamide | |
clpC1 | 4039622 | c.1083C>T | synonymous_variant | 0.43 | pyrazinamide | |
clpC1 | 4039661 | c.1044T>C | synonymous_variant | 0.42 | pyrazinamide | |
clpC1 | 4039694 | c.1011G>C | synonymous_variant | 0.36 | pyrazinamide | |
clpC1 | 4039724 | c.981A>G | synonymous_variant | 0.38 | pyrazinamide | |
clpC1 | 4039913 | c.792C>T | synonymous_variant | 0.38 | pyrazinamide | |
clpC1 | 4039931 | c.774T>C | synonymous_variant | 0.42 | pyrazinamide | |
clpC1 | 4039934 | c.771G>C | synonymous_variant | 0.31 | pyrazinamide | |
clpC1 | 4039943 | c.762G>C | synonymous_variant | 0.31 | pyrazinamide | |
clpC1 | 4039946 | c.759A>G | synonymous_variant | 0.3 | pyrazinamide | |
clpC1 | 4039952 | c.753T>C | synonymous_variant | 0.24 | pyrazinamide | |
clpC1 | 4039958 | c.747G>C | synonymous_variant | 0.21 | pyrazinamide | |
clpC1 | 4039964 | c.741C>G | synonymous_variant | 0.28 | pyrazinamide | |
clpC1 | 4039975 | p.Asp244Asn | missense_variant | 0.29 | pyrazinamide | Uncertain significance |
clpC1 | 4039979 | c.726C>G | synonymous_variant | 0.29 | pyrazinamide | |
clpC1 | 4039982 | c.723G>A | synonymous_variant | 0.35 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4040009 | c.696C>G | synonymous_variant | 0.41 | pyrazinamide | |
clpC1 | 4040015 | c.690G>C | synonymous_variant | 0.41 | pyrazinamide | |
clpC1 | 4040021 | c.684A>T | synonymous_variant | 0.39 | pyrazinamide | |
clpC1 | 4040024 | c.681A>G | synonymous_variant | 0.44 | pyrazinamide | |
clpC1 | 4040033 | c.672G>C | synonymous_variant | 0.38 | pyrazinamide | |
clpC1 | 4040048 | c.657C>T | synonymous_variant | 0.43 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4040087 | c.618G>C | synonymous_variant | 0.38 | pyrazinamide | |
clpC1 | 4040090 | c.613_615delTCTinsAGC | synonymous_variant | 0.38 | pyrazinamide | |
clpC1 | 4040093 | c.612C>G | synonymous_variant | 0.39 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4040126 | c.579C>T | synonymous_variant | 0.33 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4040495 | c.210C>T | synonymous_variant | 0.35 | pyrazinamide | |
clpC1 | 4040522 | c.183T>C | synonymous_variant | 0.31 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4040531 | c.174T>G | synonymous_variant | 0.31 | pyrazinamide | |
clpC1 | 4040540 | c.165G>T | synonymous_variant | 0.31 | pyrazinamide | |
clpC1 | 4040546 | c.159G>C | synonymous_variant | 0.26 | pyrazinamide | |
clpC1 | 4040558 | c.147G>C | synonymous_variant | 0.26 | pyrazinamide | |
clpC1 | 4040561 | c.144A>G | synonymous_variant | 0.26 | pyrazinamide | |
panD | 4044872 | c.-591C>T | upstream_gene_variant | 1.0 | pyrazinamide | |
glpK | 4138622 | c.1134C>T | synonymous_variant | 0.8 | ethambutol | Not assoc w R |
moxifloxacin | Not assoc w R | |||||
streptomycin | Not assoc w R - Interim | |||||
levofloxacin | Not assoc w R | |||||
rifampicin | Not assoc w R | |||||
isoniazid | Not assoc w R | |||||
glpK | 4138643 | c.1113A>G | synonymous_variant | 0.25 | ethambutol | Not assoc w R - Interim |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
rifampicin | Not assoc w R - Interim | |||||
isoniazid | Not assoc w R - Interim | |||||
glpK | 4138664 | c.1092G>C | synonymous_variant | 0.28 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
rifampicin | ||||||
isoniazid | ||||||
embC | 4240756 | c.894G>C | synonymous_variant | 0.2 | ethambutol | |
embC | 4240771 | c.909G>C | synonymous_variant | 0.2 | ethambutol | |
embC | 4240772 | p.Ser304Ala | missense_variant | 0.21 | ethambutol | |
embC | 4240778 | p.His306Gly | missense_variant | 0.21 | ethambutol | |
embC | 4240781 | p.Ala307Ser | missense_variant | 0.21 | ethambutol | Uncertain significance |
embC | 4240789 | c.927T>C | synonymous_variant | 0.24 | ethambutol | |
embC | 4240819 | c.957A>C | synonymous_variant | 0.3 | ethambutol | |
embC | 4240826 | p.Ala322Ser | missense_variant | 0.29 | ethambutol | |
embC | 4240831 | c.969T>G | synonymous_variant | 0.29 | ethambutol | |
embC | 4240856 | c.994_996delGCGinsAC | frameshift_variant&missense_variant | 0.26 | ethambutol | |
embC | 4240859 | c.997_999delCTGinsAC | frameshift_variant&missense_variant | 0.24 | ethambutol | |
embC | 4240876 | c.1014C>T | synonymous_variant | 0.21 | ethambutol | |
embC | 4240879 | c.1017G>T | synonymous_variant | 0.22 | ethambutol | |
embC | 4242075 | p.Arg738Gln | missense_variant | 1.0 | ethambutol | Not assoc w R |
ethA | 4328212 | c.-740delC | upstream_gene_variant | 1.0 | ethionamide | |
whiB6 | 4338595 | c.-75delG | upstream_gene_variant | 1.0 | capreomycin | Not assoc w R |
amikacin | Not assoc w R | |||||
kanamycin | Not assoc w R | |||||
whiB6 | 4338732 | c.-211C>T | upstream_gene_variant | 1.0 | capreomycin | |
amikacin | ||||||
kanamycin | ||||||
gid | 4407588 | c.615A>G | synonymous_variant | 1.0 | streptomycin | Not assoc w R |