TB-Profiler result

Run: ERR4820410
Summary

Run ID: ERR4820410

Sample name:

Date: 2024-04-15T02:05:26.537118

Number of reads: 467164

Percentage reads mapped: 21.2

Median coverage: 8.0

Strain: lineage3.1.1

Spoligotype:

Drug-resistance: RR-TB

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage3 East-African-Indian RD750 1.0
lineage3.1.1 East-African-Indian RD750 1.0
lineage3.1 East-African-Indian RD750 1.0
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin rpoB c.1321_1323delTCGinsGC Assoc w R - Interim Expert rule: Non-silent variants in RRDR of rpoB
isoniazid
ethambutol
pyrazinamide
streptomycin rrs n.888G>A Uncertain significance Mutation from literature
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
rpoB 761127 c.1321_1323delTCGinsGC frameshift_variant&missense_variant 0.7 rifampicin Assoc w R - Interim Expert rule: Non-silent variants in RRDR of rpoB
rrs 1472733 n.888G>A non_coding_transcript_exon_variant 0.35 streptomycin Uncertain significance Mutation from literature
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
gyrA 7625 c.324G>C synonymous_variant 0.43 levofloxacin
moxifloxacin
gyrA 7628 c.327G>C synonymous_variant 0.43 levofloxacin
moxifloxacin
gyrA 7631 c.330G>C synonymous_variant 0.46 levofloxacin
moxifloxacin
gyrA 7633 p.Asp111Ala missense_variant 0.58 levofloxacin
moxifloxacin
fgd1 491742 c.960T>C synonymous_variant 1.0 clofazimine Not assoc w R
pretomanid
delamanid Not assoc w R - Interim
rpoB 761030 c.1224G>C synonymous_variant 0.39 rifampicin
rpoB 761037 c.1231_1233delTTGinsCC frameshift_variant&missense_variant 0.58 rifampicin
rpoB 761051 c.1245G>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 761054 c.1248G>C synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoB 761057 c.1251G>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoB 761084 c.1278C>A synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoB 761088 c.1282_1283delAGinsTC synonymous_variant 0.88 rifampicin
rpoB 761096 c.1290G>C synonymous_variant 0.85 rifampicin
rpoB 761097 c.1291_1293delAGCinsTCG synonymous_variant 0.69 rifampicin
rpoB 761102 c.1296A>G synonymous_variant 0.86 rifampicin
rpoB 761132 c.1326G>C synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoB 761133 c.1327T>C synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoB 761150 c.1344A>T synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoB 761159 c.1353G>C synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoB 761165 c.1359G>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 762024 c.2218_2220delGTGinsAC frameshift_variant&missense_variant 0.41 rifampicin
rpoB 762051 c.2245_2247delCATinsTC frameshift_variant&missense_variant 0.56 rifampicin
rpoB 762057 p.Ile751Val missense_variant 0.65 rifampicin Uncertain significance
rpoB 762062 c.2256T>C synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>C synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoB 762071 p.Asp755Glu missense_variant 0.58 rifampicin
rpoB 762080 c.2274G>C synonymous_variant 0.65 rifampicin
rpoB 762085 p.Ala760Glu missense_variant 0.62 rifampicin
rpoB 762089 c.2283G>A synonymous_variant 0.62 rifampicin
rpoB 762092 c.2286G>A synonymous_variant 0.61 rifampicin
rpoB 762104 c.2298C>T synonymous_variant 0.43 rifampicin
rpoB 762110 c.2304G>C synonymous_variant 0.68 rifampicin
rpoB 762143 c.2337T>C synonymous_variant 0.44 rifampicin
rpoB 762149 c.2343G>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 762156 c.2350_2352delGTGinsAC frameshift_variant&missense_variant 0.41 rifampicin
rpoB 762194 c.2388G>C synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoB 762218 c.2412T>A synonymous_variant 0.52 rifampicin
rpoB 762233 c.2427G>C synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoB 762234 c.2428_2430delCCGinsTC frameshift_variant&missense_variant 0.59 rifampicin
rpoB 762239 c.2433G>A synonymous_variant 0.57 rifampicin
rpoB 762245 c.2439G>C synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoB 762254 c.2448T>C synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoB 762929 c.3123G>T synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>C synonymous_variant 0.92 rifampicin Not assoc w R
rpoB 763038 p.Thr1078Ala missense_variant 0.65 rifampicin
rpoC 763043 c.-327G>C upstream_gene_variant 0.71 rifampicin
rpoB 763053 c.3247T>C synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoB 763070 c.3264T>C synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoB 763077 p.Val1091Thr missense_variant 0.73 rifampicin
rpoC 763103 c.-267G>C upstream_gene_variant 0.7 rifampicin
rpoB 763115 c.3309T>C synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoB 763119 p.Asn1105Asp missense_variant 0.68 rifampicin
rpoB 763127 c.3321G>C synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoC 763133 c.-237G>C upstream_gene_variant 0.59 rifampicin
rpoC 763699 c.330G>T synonymous_variant 0.64 rifampicin
rpoC 763708 c.339G>C synonymous_variant 0.73 rifampicin
rpoC 763714 c.345G>C synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoC 763717 c.348T>C synonymous_variant 0.81 rifampicin Not assoc w R - Interim
rpoC 763718 p.Leu117Val missense_variant 0.64 rifampicin
rpoC 763723 c.354G>C synonymous_variant 0.73 rifampicin
rpoC 763724 p.Asp119Asn missense_variant 0.73 rifampicin
rpoC 763729 c.360G>C synonymous_variant 0.71 rifampicin
rpoC 763732 c.363C>G synonymous_variant 0.8 rifampicin
rpoC 763735 c.366G>C synonymous_variant 0.76 rifampicin
rpoC 763744 c.375G>C synonymous_variant 0.67 rifampicin
rpoC 763751 p.Ile128Val missense_variant 0.84 rifampicin
rpoC 763772 p.Val135Met missense_variant 0.79 rifampicin
rpoC 764405 c.1036_1038delAGGinsCC frameshift_variant&missense_variant 0.6 rifampicin
rpoC 764410 c.1041G>C synonymous_variant 0.67 rifampicin
rpoC 764424 p.Asn352Thr missense_variant 0.7 rifampicin
rpoC 764428 c.1059G>A synonymous_variant 0.7 rifampicin
rpoC 764431 c.1062G>C synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoC 764434 c.1065A>G synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoC 764435 c.1066_1068delAGGinsCC frameshift_variant&missense_variant 0.7 rifampicin
rpoC 764441 p.Ile358Leu missense_variant 0.75 rifampicin
rpoC 764446 p.Asp359Glu missense_variant 0.76 rifampicin
rpoC 764455 c.1086G>C synonymous_variant 0.77 rifampicin
rpoC 764458 c.1089G>C synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoC 764461 c.1092A>G synonymous_variant 0.78 rifampicin Not assoc w R - Interim
rpoC 764485 c.1116G>C synonymous_variant 0.83 rifampicin
rpoC 764491 c.1122G>T synonymous_variant 0.81 rifampicin
rpoC 764497 c.1128A>G synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoC 764503 c.1134G>T synonymous_variant 0.88 rifampicin
rpoC 764509 c.1140G>C synonymous_variant 0.89 rifampicin Not assoc w R - Interim
rpoC 764512 c.1143G>C synonymous_variant 0.82 rifampicin
rpoC 764521 c.1152T>C synonymous_variant 0.79 rifampicin Not assoc w R - Interim
rpoC 764536 c.1167G>C synonymous_variant 0.71 rifampicin
rpoC 764543 c.1174_1176delACCinsGG frameshift_variant&missense_variant 0.47 rifampicin
rpoC 764548 c.1179G>C synonymous_variant 0.46 rifampicin
rpoC 764566 c.1197C>G synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoC 764581 c.1212T>C synonymous_variant 0.47 rifampicin
rpoC 764582 p.Leu405Met missense_variant 0.47 rifampicin
rpoC 764602 c.1233C>T synonymous_variant 0.59 rifampicin
rpoC 764605 c.1236G>T synonymous_variant 0.65 rifampicin
rpoC 764611 c.1242G>T synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoC 764626 c.1257C>T synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 764632 c.1263T>C synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoC 764647 c.1278C>T synonymous_variant 0.56 rifampicin
rpoC 764650 c.1281G>T synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoC 764653 c.1284G>C synonymous_variant 0.58 rifampicin
rpoC 764656 c.1287C>T synonymous_variant 0.68 rifampicin
rpoC 764662 c.1293G>C synonymous_variant 0.81 rifampicin Not assoc w R - Interim
rpoC 764671 c.1302G>C synonymous_variant 0.22 rifampicin
rpoC 764677 c.1308C>G synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoC 764678 p.Lys437Gln missense_variant 0.54 rifampicin
rpoC 764692 c.1323C>T synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 764706 p.Leu446Gln missense_variant 0.53 rifampicin Uncertain significance
rpoC 764713 c.1344G>C synonymous_variant 0.53 rifampicin Not assoc w R - Interim
mmpL5 775639 p.Ile948Val missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
mmpL5 776100 p.Thr794Ile missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
rpsL 781745 c.186G>A synonymous_variant 0.32 streptomycin
rpsL 781751 c.192G>C synonymous_variant 0.55 streptomycin
rpsL 781760 c.201T>C synonymous_variant 0.46 streptomycin
rpsL 781766 c.207C>T synonymous_variant 0.65 streptomycin Not assoc w R - Interim
rpsL 781772 c.213C>T synonymous_variant 0.24 streptomycin Not assoc w R - Interim
rpsL 781796 p.Met79Ile missense_variant 0.75 streptomycin
rpsL 781802 c.243G>C synonymous_variant 0.68 streptomycin
rpsL 781811 c.252C>T synonymous_variant 0.75 streptomycin
rpsL 781814 c.255C>T synonymous_variant 0.65 streptomycin
rpsL 781817 c.258G>T synonymous_variant 0.65 streptomycin
rpsL 781832 c.273T>C synonymous_variant 0.62 streptomycin
rpsL 781835 c.276T>C synonymous_variant 0.5 streptomycin Not assoc w R - Interim
rpsL 781841 c.282C>T synonymous_variant 0.56 streptomycin
rrs 1472075 n.230A>G non_coding_transcript_exon_variant 1.0 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472078 n.233C>T non_coding_transcript_exon_variant 0.95 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.91 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472122 n.277G>T non_coding_transcript_exon_variant 0.85 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472123 n.278A>T non_coding_transcript_exon_variant 0.88 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472124 n.279C>T non_coding_transcript_exon_variant 0.9 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472150 n.305T>A non_coding_transcript_exon_variant 0.8 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472150 n.305T>G non_coding_transcript_exon_variant 0.19 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472151 n.306C>A non_coding_transcript_exon_variant 0.2 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472155 n.310C>T non_coding_transcript_exon_variant 0.84 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472160 n.315C>T non_coding_transcript_exon_variant 0.72 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472172 n.327T>C non_coding_transcript_exon_variant 0.2 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472225 n.380C>A non_coding_transcript_exon_variant 0.63 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Uncertain significance
rrs 1472251 n.406G>A non_coding_transcript_exon_variant 0.97 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472258 n.413A>G non_coding_transcript_exon_variant 0.63 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472259 n.414C>A non_coding_transcript_exon_variant 0.94 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472344 n.499C>T non_coding_transcript_exon_variant 1.0 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472382 n.537G>A non_coding_transcript_exon_variant 0.5 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472400 n.555C>T non_coding_transcript_exon_variant 0.75 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472530 n.685G>A non_coding_transcript_exon_variant 0.5 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472537 n.692C>T non_coding_transcript_exon_variant 0.63 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472549 n.704G>A non_coding_transcript_exon_variant 0.26 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472566 n.721G>A non_coding_transcript_exon_variant 0.65 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472571 n.726G>C non_coding_transcript_exon_variant 0.73 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472579 n.734G>T non_coding_transcript_exon_variant 0.55 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472580 n.735C>T non_coding_transcript_exon_variant 0.29 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472581 n.736A>T non_coding_transcript_exon_variant 0.69 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472584 n.739A>T non_coding_transcript_exon_variant 0.31 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472598 n.753A>C non_coding_transcript_exon_variant 0.68 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472599 n.754G>T non_coding_transcript_exon_variant 0.67 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472616 n.771G>A non_coding_transcript_exon_variant 0.51 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472692 n.847T>C non_coding_transcript_exon_variant 0.45 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472697 n.852T>C non_coding_transcript_exon_variant 0.12 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472707 n.862A>T non_coding_transcript_exon_variant 0.45 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472713 n.868T>C non_coding_transcript_exon_variant 0.33 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472714 n.869A>G non_coding_transcript_exon_variant 0.67 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472716 n.871C>T non_coding_transcript_exon_variant 0.34 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472742 n.897C>T non_coding_transcript_exon_variant 0.33 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472744 n.899A>G non_coding_transcript_exon_variant 0.38 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472781 n.936C>T non_coding_transcript_exon_variant 0.37 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472790 n.945T>C non_coding_transcript_exon_variant 0.58 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472793 n.948A>T non_coding_transcript_exon_variant 0.4 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472803 n.958T>A non_coding_transcript_exon_variant 0.38 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472824 n.979T>A non_coding_transcript_exon_variant 0.97 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472825 n.980G>A non_coding_transcript_exon_variant 0.46 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472827 n.982G>T non_coding_transcript_exon_variant 0.29 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472828 n.983T>C non_coding_transcript_exon_variant 1.0 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472895 n.1050C>T non_coding_transcript_exon_variant 0.9 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472954 n.1109T>C non_coding_transcript_exon_variant 0.56 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472956 n.1111T>C non_coding_transcript_exon_variant 0.97 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472957 n.1112C>T non_coding_transcript_exon_variant 0.66 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472958 n.1113A>G non_coding_transcript_exon_variant 0.3 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472973 n.1128A>G non_coding_transcript_exon_variant 0.57 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472973 n.1128A>T non_coding_transcript_exon_variant 0.43 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472974 n.1129A>G non_coding_transcript_exon_variant 0.3 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472988 n.1143T>C non_coding_transcript_exon_variant 0.28 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472990 n.1145A>G non_coding_transcript_exon_variant 0.95 streptomycin Uncertain significance
kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472992 n.1147A>G non_coding_transcript_exon_variant 0.56 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473005 n.1160C>T non_coding_transcript_exon_variant 0.62 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473035 n.1190G>A non_coding_transcript_exon_variant 0.95 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1473055 n.1210C>T non_coding_transcript_exon_variant 0.88 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473056 n.1211A>T non_coding_transcript_exon_variant 0.96 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1473066 n.1221A>G non_coding_transcript_exon_variant 0.91 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473080 n.1235C>T non_coding_transcript_exon_variant 0.62 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473081 n.1236C>T non_coding_transcript_exon_variant 0.63 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473088 n.1243A>G non_coding_transcript_exon_variant 0.96 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473093 n.1248C>T non_coding_transcript_exon_variant 0.85 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473100 n.1255G>A non_coding_transcript_exon_variant 0.98 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473101 n.1256C>T non_coding_transcript_exon_variant 0.44 streptomycin
kanamycin Uncertain significance
capreomycin
amikacin Uncertain significance
rrs 1473102 n.1257C>T non_coding_transcript_exon_variant 0.39 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473104 n.1259C>T non_coding_transcript_exon_variant 0.98 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473110 n.1265T>G non_coding_transcript_exon_variant 0.95 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473111 n.1266A>G non_coding_transcript_exon_variant 1.0 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473115 n.1270G>T non_coding_transcript_exon_variant 0.13 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473121 n.1276T>C non_coding_transcript_exon_variant 0.84 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1473123 n.1278A>T non_coding_transcript_exon_variant 0.92 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473130 n.1285G>A non_coding_transcript_exon_variant 0.7 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.89 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473148 n.1303G>T non_coding_transcript_exon_variant 0.17 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473163 n.1318C>A non_coding_transcript_exon_variant 0.17 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.88 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473172 n.1327T>G non_coding_transcript_exon_variant 0.82 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473173 n.1328C>T non_coding_transcript_exon_variant 0.92 streptomycin Not assoc w R
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1473221 n.1376C>T non_coding_transcript_exon_variant 0.89 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473252 n.1407T>C non_coding_transcript_exon_variant 0.9 streptomycin Uncertain significance
kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1473259 n.1414C>T non_coding_transcript_exon_variant 0.91 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1473276 n.1431A>C non_coding_transcript_exon_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473277 n.1432G>A non_coding_transcript_exon_variant 0.86 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473288 n.1443_1455delCTCGGGAGGGAGCinsGGCTTGTCCGGGGGGAGT non_coding_transcript_exon_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473301 n.1456T>G non_coding_transcript_exon_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473316 n.1471C>T non_coding_transcript_exon_variant 1.0 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrl 1474164 n.507C>T non_coding_transcript_exon_variant 0.8 capreomycin
linezolid
rrl 1474181 n.524C>A non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1474184 n.527C>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474197 n.540C>T non_coding_transcript_exon_variant 0.97 capreomycin Uncertain significance
linezolid
rrl 1474199 n.542G>C non_coding_transcript_exon_variant 0.88 capreomycin
linezolid
rrl 1474200 n.545delT non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 0.9 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474636 n.979A>C non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474637 n.980C>G non_coding_transcript_exon_variant 0.78 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474638 n.981C>G non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474643 n.986A>G non_coding_transcript_exon_variant 0.75 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474663 n.1006C>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474672 n.1015C>T non_coding_transcript_exon_variant 0.67 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474676 n.1019T>A non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474677 n.1020A>G non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474692 n.1035G>A non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474706 n.1049G>A non_coding_transcript_exon_variant 0.67 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474734 n.1077G>A non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1474753 n.1096_1097delACinsT non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474760 n.1103A>G non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.98 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474824 n.1167A>G non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474830 n.1173A>G non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474831 n.1174A>C non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474831 n.1174A>T non_coding_transcript_exon_variant 0.6 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474832 n.1175A>T non_coding_transcript_exon_variant 0.59 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474864 n.1207C>T non_coding_transcript_exon_variant 1.0 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1474903 n.1246T>C non_coding_transcript_exon_variant 0.85 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474913 n.1256T>C non_coding_transcript_exon_variant 0.81 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475777 n.2120A>T non_coding_transcript_exon_variant 0.92 capreomycin
linezolid
rrl 1475881 n.2224T>C non_coding_transcript_exon_variant 0.27 capreomycin
linezolid
rrl 1475883 n.2226A>C non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid
rrl 1475883 n.2226A>T non_coding_transcript_exon_variant 0.52 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475884 n.2227A>G non_coding_transcript_exon_variant 0.66 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475898 n.2241A>G non_coding_transcript_exon_variant 0.62 capreomycin Uncertain significance
linezolid
rrl 1475899 n.2242G>A non_coding_transcript_exon_variant 0.62 capreomycin Uncertain significance
linezolid
rrl 1475900 n.2243A>G non_coding_transcript_exon_variant 0.56 capreomycin Uncertain significance
linezolid
rrl 1475902 n.2245T>C non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid
rrl 1475906 n.2249C>T non_coding_transcript_exon_variant 0.61 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475916 n.2259C>G non_coding_transcript_exon_variant 0.96 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475937 n.2280A>T non_coding_transcript_exon_variant 0.83 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476179 n.2522C>T non_coding_transcript_exon_variant 0.93 capreomycin
linezolid
rrl 1476194 n.2537A>T non_coding_transcript_exon_variant 0.68 capreomycin
linezolid
rrl 1476200 n.2543A>T non_coding_transcript_exon_variant 1.0 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476204 n.2547C>T non_coding_transcript_exon_variant 0.88 capreomycin
linezolid
rrl 1476207 n.2550T>C non_coding_transcript_exon_variant 0.81 capreomycin
linezolid
rrl 1476214 n.2557G>T non_coding_transcript_exon_variant 0.94 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476215 n.2558C>T non_coding_transcript_exon_variant 0.88 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.78 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476250 n.2593C>G non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476251 n.2594T>C non_coding_transcript_exon_variant 0.55 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476252 n.2595T>A non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid
rrl 1476252 n.2595T>G non_coding_transcript_exon_variant 0.43 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476256 n.2599A>G non_coding_transcript_exon_variant 0.43 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476257 n.2600G>C non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476260 n.2603A>G non_coding_transcript_exon_variant 1.0 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476267 n.2610G>T non_coding_transcript_exon_variant 0.4 capreomycin
linezolid
rrl 1476280 n.2623A>C non_coding_transcript_exon_variant 0.8 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476357 n.2700T>C non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1476359 n.2702C>G non_coding_transcript_exon_variant 0.94 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476381 n.2724G>C non_coding_transcript_exon_variant 0.95 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476428 n.2771C>T non_coding_transcript_exon_variant 0.75 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476429 n.2772A>T non_coding_transcript_exon_variant 0.73 capreomycin Uncertain significance
linezolid
rrl 1476466 n.2809C>T non_coding_transcript_exon_variant 0.96 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476481 n.2824T>C non_coding_transcript_exon_variant 0.54 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476506 n.2849T>C non_coding_transcript_exon_variant 0.9 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476513 n.2856G>T non_coding_transcript_exon_variant 0.81 capreomycin
linezolid
rrl 1476515 n.2858C>T non_coding_transcript_exon_variant 0.76 capreomycin Uncertain significance
linezolid
rrl 1476567 n.2910C>T non_coding_transcript_exon_variant 0.75 capreomycin Uncertain significance
linezolid Uncertain significance
rpsA 1834195 c.654G>C synonymous_variant 0.68 pyrazinamide
rpsA 1834228 c.687C>T synonymous_variant 0.82 pyrazinamide
rpsA 1834234 c.693G>C synonymous_variant 0.9 pyrazinamide
rpsA 1834240 c.699T>C synonymous_variant 0.87 pyrazinamide
rpsA 1834246 c.705G>T synonymous_variant 0.79 pyrazinamide
rpsA 1834249 c.708T>C synonymous_variant 0.92 pyrazinamide
rpsA 1834261 c.720A>G synonymous_variant 0.95 pyrazinamide Not assoc w R - Interim
rpsA 1834264 c.723G>C synonymous_variant 0.95 pyrazinamide
rpsA 1834294 c.753G>C synonymous_variant 0.86 pyrazinamide
rpsA 1834298 p.Gln253Glu missense_variant 0.81 pyrazinamide
rpsA 1834303 c.762T>C synonymous_variant 0.36 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.73 pyrazinamide
rpsA 1834307 c.766_768delGACinsCG frameshift_variant&missense_variant 0.73 pyrazinamide Uncertain significance
rpsA 1834312 c.771G>A synonymous_variant 0.73 pyrazinamide
rpsA 1834327 c.786G>T synonymous_variant 0.76 pyrazinamide
rpsA 1834345 c.804C>T synonymous_variant 0.62 pyrazinamide
rpsA 1834411 c.870T>C synonymous_variant 0.54 pyrazinamide
rpsA 1834417 c.876G>C synonymous_variant 0.54 pyrazinamide
rpsA 1834435 c.894G>C synonymous_variant 0.73 pyrazinamide
rpsA 1834451 c.910_912delTTGinsCC frameshift_variant&missense_variant 0.6 pyrazinamide Uncertain significance
rpsA 1834456 c.915T>C synonymous_variant 0.6 pyrazinamide
rpsA 1834459 c.918G>C synonymous_variant 0.69 pyrazinamide
rpsA 1834465 c.924T>C synonymous_variant 0.69 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.67 pyrazinamide
rpsA 1834486 p.Glu315Asp missense_variant 0.67 pyrazinamide
rpsA 1834489 c.948T>C synonymous_variant 0.67 pyrazinamide
embC 4240172 p.Val104Met missense_variant 1.0 ethambutol Not assoc w R
embC 4242075 p.Arg738Gln missense_variant 1.0 ethambutol Not assoc w R
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 capreomycin
amikacin
kanamycin