TB-Profiler result

Run: ERR4821704
Summary

Run ID: ERR4821704

Sample name:

Date: 01-04-2023 17:24:17

Number of reads: 641939

Percentage reads mapped: 38.15

Strain: lineage4.3.3

Drug-resistance: MDR-TB

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.3 Euro-American (LAM) mainly-LAM None 1.0
lineage4.3.3 Euro-American (LAM) LAM;T RD115 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
rpoB 761127 p.Ser441Ala missense_variant 0.2 rifampicin
rrs 1472359 n.514A>C non_coding_transcript_exon_variant 0.57 streptomycin
rrs 1472733 n.888G>A non_coding_transcript_exon_variant 0.57 streptomycin
fabG1 1673425 c.-15C>T upstream_gene_variant 1.0 isoniazid, ethionamide
katG 2155168 p.Ser315Thr missense_variant 1.0 isoniazid
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7585 p.Ser95Thr missense_variant 1.0
gyrA 8040 p.Gly247Ser missense_variant 1.0
gyrA 9304 p.Gly668Asp missense_variant 1.0
mshA 575405 p.Arg20Cys missense_variant 0.18
mshA 576690 p.Tyr448Phe missense_variant 0.13
ccsA 620033 p.Ala48Val missense_variant 0.15
rpoB 761015 c.1209G>C synonymous_variant 0.18
rpoB 761021 c.1215G>C synonymous_variant 0.2
rpoB 761036 c.1230G>C synonymous_variant 0.25
rpoB 761037 c.1231T>C synonymous_variant 0.33
rpoB 761054 c.1248G>C synonymous_variant 0.29
rpoB 761058 p.Val418Thr missense_variant 0.5
rpoB 761088 c.1282_1283delAGinsTC synonymous_variant 0.38
rpoB 761096 c.1290G>C synonymous_variant 0.33
rpoB 761102 c.1296A>G synonymous_variant 0.25
rpoB 761132 c.1326G>C synonymous_variant 0.2
rpoB 761133 c.1327T>C synonymous_variant 0.21
rpoB 761150 c.1344A>C synonymous_variant 0.13
rpoB 761154 p.Ser450Asn missense_variant 0.13
rpoB 761159 c.1353G>C synonymous_variant 0.13
rpoB 761165 c.1359G>C synonymous_variant 0.12
rpoB 761180 c.1374A>C synonymous_variant 0.12
rpoB 761534 c.1728G>C synonymous_variant 0.25
rpoB 761537 c.1731C>G synonymous_variant 0.22
rpoB 761557 p.Ala584Gly missense_variant 0.2
rpoB 761562 p.Ala586Ser missense_variant 0.2
rpoB 761565 p.Met587Leu missense_variant 0.2
rpoB 761570 c.1764T>C synonymous_variant 0.2
rpoB 761579 c.1773G>C synonymous_variant 0.2
rpoB 761990 c.2184G>C synonymous_variant 0.25
rpoB 761997 p.Leu731Ile missense_variant 0.17
rpoB 762003 p.Asn733Gln missense_variant 0.17
rpoB 762009 p.Leu735Val missense_variant 0.15
rpoB 762016 p.Glu737Ala missense_variant 0.15
rpoB 762024 p.Val740Met missense_variant 0.15
rpoB 762053 c.2247T>C synonymous_variant 0.18
rpoB 762212 c.2406G>C synonymous_variant 0.21
rpoB 762228 c.2422C>T synonymous_variant 0.14
rpoB 762245 c.2439G>C synonymous_variant 0.21
rpoB 762248 c.2442G>C synonymous_variant 0.14
rpoB 762251 c.2445G>A synonymous_variant 0.17
rpoB 762254 c.2448T>C synonymous_variant 0.23
rpoB 762287 c.2481C>T synonymous_variant 0.12
rpoB 762293 c.2487T>C synonymous_variant 0.19
rpoB 762296 c.2490G>C synonymous_variant 0.12
rpoB 762849 p.Tyr1015Asp missense_variant 0.12
rpoB 762855 p.Val1017Ile missense_variant 0.11
rpoB 762858 p.Thr1018Ser missense_variant 0.12
rpoB 762879 p.Met1025Leu missense_variant 0.48
rpoC 762887 c.-483G>C upstream_gene_variant 0.26
rpoC 762896 c.-474G>C upstream_gene_variant 0.25
rpoC 762902 c.-468C>T upstream_gene_variant 0.15
rpoC 762911 c.-459C>T upstream_gene_variant 0.2
rpoC 762917 c.-453C>T upstream_gene_variant 0.19
rpoC 762920 c.-450C>T upstream_gene_variant 0.19
rpoC 762926 c.-444C>G upstream_gene_variant 0.21
rpoC 762929 c.-441G>T upstream_gene_variant 0.41
rpoC 762938 c.-432G>C upstream_gene_variant 0.25
rpoC 762944 c.-426C>T upstream_gene_variant 0.29
rpoC 762962 c.-408C>T upstream_gene_variant 0.2
rpoC 763468 c.99G>C synonymous_variant 0.12
rpoC 763483 c.114G>C synonymous_variant 0.29
rpoC 763486 c.117T>C synonymous_variant 0.29
rpoC 763492 c.123G>C synonymous_variant 0.28
rpoC 763507 c.138G>C synonymous_variant 0.36
rpoC 763528 c.159G>C synonymous_variant 0.36
rpoC 763531 c.162G>C synonymous_variant 0.36
rpoC 763534 c.165T>C synonymous_variant 0.36
rpoC 763537 c.168C>G synonymous_variant 0.36
rpoC 763546 c.177A>G synonymous_variant 0.36
rpoC 763550 p.Tyr61Ala missense_variant 0.38
rpoC 763570 c.201G>C synonymous_variant 0.22
rpoC 763578 p.Phe70Tyr missense_variant 0.21
rpoC 763585 c.216C>G synonymous_variant 0.28
rpoC 763589 p.Ile74Val missense_variant 0.21
rpoC 763606 c.237C>A synonymous_variant 0.12
rpoC 763615 c.246G>C synonymous_variant 0.12
rpoC 763622 p.Ala85Ser missense_variant 0.19
rpoC 763636 c.267T>C synonymous_variant 0.24
rpoC 763642 c.273G>C synonymous_variant 0.21
rpoC 763647 p.Gly93Ala missense_variant 0.36
rpoC 763655 p.Glu96Lys missense_variant 0.38
rpoC 763660 c.291T>C synonymous_variant 0.41
rpoC 763666 c.297G>C synonymous_variant 0.11
rpoC 763669 c.300C>G synonymous_variant 0.33
rpoC 763675 c.306C>G synonymous_variant 0.16
rpoC 763696 c.327T>C synonymous_variant 0.16
rpoC 763699 c.330G>T synonymous_variant 0.24
rpoC 763708 c.339G>C synonymous_variant 0.44
rpoC 763714 c.345G>C synonymous_variant 0.47
rpoC 763717 c.348T>C synonymous_variant 0.47
rpoC 763718 p.Leu117Val missense_variant 0.19
rpoC 763723 c.354G>C synonymous_variant 0.4
rpoC 763724 p.Asp119Asn missense_variant 0.4
rpoC 763729 c.360G>C synonymous_variant 0.36
rpoC 763732 c.363C>G synonymous_variant 0.33
rpoC 763735 c.366G>C synonymous_variant 0.43
rpoC 763744 c.375G>C synonymous_variant 0.21
rpoC 763751 p.Ile128Val missense_variant 0.42
rpoC 763772 p.Val135Met missense_variant 0.2
rpoC 764353 c.984G>T synonymous_variant 0.17
rpoC 764359 c.990C>G synonymous_variant 0.2
rpoC 764365 c.996C>T synonymous_variant 0.33
rpoC 764371 c.1002G>C synonymous_variant 0.25
rpoC 764374 c.1005C>T synonymous_variant 0.22
rpoC 764377 c.1008C>G synonymous_variant 0.22
rpoC 764380 c.1011G>C synonymous_variant 0.38
rpoC 764387 c.1018T>C synonymous_variant 0.3
rpoC 764404 c.1035C>T synonymous_variant 0.2
rpoC 764405 c.1036_1038delAGGinsCGT synonymous_variant 0.33
rpoC 764419 c.1050C>T synonymous_variant 0.22
rpoC 764566 c.1197C>G synonymous_variant 0.17
rpoC 764572 c.1203G>C synonymous_variant 0.16
rpoC 764575 c.1206T>G synonymous_variant 0.16
rpoC 764581 c.1212T>C synonymous_variant 0.17
rpoC 764582 p.Leu405Met missense_variant 0.21
rpoC 764605 c.1236G>C synonymous_variant 0.25
rpoC 764611 c.1242G>C synonymous_variant 0.25
rpoC 764620 c.1251G>C synonymous_variant 0.14
rpoC 764623 c.1254C>G synonymous_variant 0.32
rpoC 764635 c.1266C>G synonymous_variant 0.21
rpoC 764644 c.1275G>T synonymous_variant 0.14
rpoC 764650 c.1281G>T synonymous_variant 0.24
rpoC 764656 c.1287C>A synonymous_variant 0.14
rpoC 764662 c.1293G>C synonymous_variant 0.14
rpoC 764664 p.Val432Gly missense_variant 0.12
rpoC 764671 c.1302G>C synonymous_variant 0.23
rpoC 764703 p.Lys445Arg missense_variant 0.14
rpoC 764706 p.Leu446Gln missense_variant 0.17
rpoC 764995 c.1626C>G synonymous_variant 1.0
rpoC 765822 p.Ala818Val missense_variant 0.17
rpoC 765937 c.2568T>C synonymous_variant 0.44
rpoC 765940 c.2571A>T synonymous_variant 0.44
rpoC 765947 c.2578T>C synonymous_variant 0.44
rpoC 765958 c.2589C>G synonymous_variant 0.5
rpoC 765962 c.2593T>C synonymous_variant 0.5
rpoC 765967 c.2598C>T synonymous_variant 0.57
rpoC 765988 c.2619G>C synonymous_variant 0.5
rpoC 765991 c.2622C>G synonymous_variant 0.5
rpoC 765994 c.2625A>C synonymous_variant 0.43
rpoC 766003 c.2634G>C synonymous_variant 0.67
rpoC 766009 c.2640G>C synonymous_variant 0.8
rpoC 766021 c.2652G>C synonymous_variant 0.38
rpoC 766027 c.2658G>C synonymous_variant 0.29
rpoC 766799 p.Ala1144Ser missense_variant 0.14
rpoC 766804 c.3435A>G synonymous_variant 0.13
rpoC 766807 c.3438T>C synonymous_variant 0.12
rpoC 766811 p.Ser1148Asp missense_variant 0.14
rpoC 766820 p.Asp1151Ser missense_variant 0.12
rpoC 766843 c.3474T>G synonymous_variant 0.11
mmpL5 775616 c.2865G>A synonymous_variant 0.13
mmpL5 775639 p.Ile948Val missense_variant 1.0
mmpL5 777589 p.Ala298Ser missense_variant 0.12
mmpS5 778482 p.Ala142Ser missense_variant 0.12
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
rpsL 781751 c.192G>C synonymous_variant 0.15
rpsL 781760 c.201T>C synonymous_variant 0.15
rpsL 781766 c.207C>T synonymous_variant 0.2
rpsL 781796 p.Met79Ile missense_variant 0.17
rpsL 781802 c.243G>C synonymous_variant 0.15
rpsL 781805 c.246G>T synonymous_variant 0.17
rpsL 781811 c.252C>T synonymous_variant 0.17
rpsL 781814 c.255C>T synonymous_variant 0.17
rpsL 781817 c.258G>T synonymous_variant 0.17
rpsL 781829 c.270G>C synonymous_variant 0.14
rpsL 781832 c.273T>C synonymous_variant 0.14
rpsL 781838 c.279G>T synonymous_variant 0.14
rplC 800632 c.-177_-176delATinsTC upstream_gene_variant 0.21
rplC 800639 c.-170C>G upstream_gene_variant 0.25
rplC 800645 c.-164C>G upstream_gene_variant 0.27
rplC 800648 c.-161A>G upstream_gene_variant 0.27
rplC 800654 c.-155T>C upstream_gene_variant 0.23
rplC 800667 c.-142_-140delTCGinsAGC upstream_gene_variant 0.23
rplC 800672 c.-137G>C upstream_gene_variant 0.21
rplC 800693 c.-116A>G upstream_gene_variant 0.17
fbiC 1303095 c.165G>A synonymous_variant 1.0
fbiC 1304962 p.Trp678Gly missense_variant 1.0
embR 1416431 p.Ala306Val missense_variant 0.12
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrs 1472068 n.223T>G non_coding_transcript_exon_variant 0.6
rrs 1472075 n.230A>G non_coding_transcript_exon_variant 0.75
rrs 1472078 n.233C>T non_coding_transcript_exon_variant 0.8
rrs 1472082 n.237G>A non_coding_transcript_exon_variant 0.17
rrs 1472102 n.257G>A non_coding_transcript_exon_variant 0.15
rrs 1472106 n.261G>A non_coding_transcript_exon_variant 0.14
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.75
rrs 1472112 n.267C>T non_coding_transcript_exon_variant 0.17
rrs 1472113 n.268T>C non_coding_transcript_exon_variant 0.17
rrs 1472122 n.277G>T non_coding_transcript_exon_variant 0.2
rrs 1472123 n.278A>G non_coding_transcript_exon_variant 0.57
rrs 1472124 n.279C>T non_coding_transcript_exon_variant 0.64
rrs 1472150 n.305T>A non_coding_transcript_exon_variant 0.92
rrs 1472150 n.305T>G non_coding_transcript_exon_variant 0.93
rrs 1472151 n.306C>A non_coding_transcript_exon_variant 0.51
rrs 1472155 n.310C>T non_coding_transcript_exon_variant 0.63
rrs 1472160 n.315C>T non_coding_transcript_exon_variant 0.15
rrs 1472172 n.327T>C non_coding_transcript_exon_variant 0.65
rrs 1472225 n.380C>A non_coding_transcript_exon_variant 0.12
rrs 1472240 n.395G>A non_coding_transcript_exon_variant 0.13
rrs 1472251 n.406G>A non_coding_transcript_exon_variant 1.0
rrs 1472258 n.413A>G non_coding_transcript_exon_variant 0.25
rrs 1472259 n.414C>A non_coding_transcript_exon_variant 0.53
rrs 1472285 n.440A>G non_coding_transcript_exon_variant 1.0
rrs 1472325 n.480G>C non_coding_transcript_exon_variant 0.75
rrs 1472330 n.485G>T non_coding_transcript_exon_variant 0.75
rrs 1472338 n.493A>G non_coding_transcript_exon_variant 0.75
rrs 1472344 n.499C>T non_coding_transcript_exon_variant 0.5
rrs 1472379 n.534T>C non_coding_transcript_exon_variant 0.44
rrs 1472400 n.555C>T non_coding_transcript_exon_variant 0.44
rrs 1472498 n.653C>A non_coding_transcript_exon_variant 0.75
rrs 1472507 n.662C>G non_coding_transcript_exon_variant 0.77
rrs 1472513 n.668T>C non_coding_transcript_exon_variant 0.13
rrs 1472517 n.672T>A non_coding_transcript_exon_variant 0.79
rrs 1472518 n.673G>T non_coding_transcript_exon_variant 0.79
rrs 1472530 n.685G>A non_coding_transcript_exon_variant 0.92
rrs 1472537 n.692C>T non_coding_transcript_exon_variant 0.93
rrs 1472544 n.699C>A non_coding_transcript_exon_variant 0.9
rrs 1472545 n.700A>T non_coding_transcript_exon_variant 0.9
rrs 1472566 n.721G>A non_coding_transcript_exon_variant 0.89
rrs 1472571 n.726G>C non_coding_transcript_exon_variant 0.88
rrs 1472579 n.734G>C non_coding_transcript_exon_variant 0.53
rrs 1472579 n.734G>T non_coding_transcript_exon_variant 0.83
rrs 1472580 n.735C>T non_coding_transcript_exon_variant 0.16
rrs 1472581 n.736A>T non_coding_transcript_exon_variant 0.96
rrs 1472598 n.753A>C non_coding_transcript_exon_variant 0.85
rrs 1472599 n.754G>T non_coding_transcript_exon_variant 0.84
rrs 1472616 n.771G>A non_coding_transcript_exon_variant 0.57
rrs 1472655 n.810G>A non_coding_transcript_exon_variant 0.84
rrs 1472658 n.813G>A non_coding_transcript_exon_variant 0.71
rrs 1472660 n.815T>C non_coding_transcript_exon_variant 0.13
rrs 1472661 n.816A>G non_coding_transcript_exon_variant 0.71
rrs 1472670 n.825G>T non_coding_transcript_exon_variant 0.7
rrs 1472673 n.828T>G non_coding_transcript_exon_variant 0.79
rrs 1472675 n.830T>C non_coding_transcript_exon_variant 0.83
rrs 1472677 n.832C>T non_coding_transcript_exon_variant 0.9
rrs 1472681 n.837_838delTT non_coding_transcript_exon_variant 0.9
rrs 1472687 n.842_843insC non_coding_transcript_exon_variant 0.81
rrs 1472687 n.843dupT non_coding_transcript_exon_variant 0.67
rrs 1472690 n.845C>A non_coding_transcript_exon_variant 0.83
rrs 1472697 n.852T>C non_coding_transcript_exon_variant 0.57
rrs 1472713 n.868T>C non_coding_transcript_exon_variant 0.6
rrs 1472714 n.869A>G non_coding_transcript_exon_variant 0.38
rrs 1472716 n.871C>T non_coding_transcript_exon_variant 0.58
rrs 1472742 n.897C>T non_coding_transcript_exon_variant 0.56
rrs 1472744 n.899A>G non_coding_transcript_exon_variant 0.56
rrs 1472755 n.910G>A non_coding_transcript_exon_variant 0.13
rrs 1472781 n.936C>T non_coding_transcript_exon_variant 0.56
rrs 1472790 n.945T>C non_coding_transcript_exon_variant 0.42
rrs 1472793 n.948A>T non_coding_transcript_exon_variant 0.57
rrs 1472803 n.958T>A non_coding_transcript_exon_variant 0.62
rrs 1472824 n.979T>A non_coding_transcript_exon_variant 0.86
rrs 1472825 n.980G>A non_coding_transcript_exon_variant 0.24
rrs 1472827 n.982G>T non_coding_transcript_exon_variant 0.5
rrs 1472828 n.983T>C non_coding_transcript_exon_variant 0.96
rrs 1472895 n.1050C>T non_coding_transcript_exon_variant 0.83
rrs 1472952 n.1107T>C non_coding_transcript_exon_variant 0.34
rrs 1472955 n.1110C>T non_coding_transcript_exon_variant 0.33
rrs 1472956 n.1111T>C non_coding_transcript_exon_variant 0.95
rrs 1472957 n.1112C>T non_coding_transcript_exon_variant 0.42
rrs 1472958 n.1113A>G non_coding_transcript_exon_variant 0.51
rrs 1472973 n.1128A>T non_coding_transcript_exon_variant 0.95
rrs 1472974 n.1129A>G non_coding_transcript_exon_variant 0.48
rrs 1472987 n.1142G>A non_coding_transcript_exon_variant 0.27
rrs 1472988 n.1143T>C non_coding_transcript_exon_variant 0.58
rrs 1472989 n.1144G>A non_coding_transcript_exon_variant 0.27
rrs 1472990 n.1145A>G non_coding_transcript_exon_variant 0.95
rrs 1473035 n.1190G>A non_coding_transcript_exon_variant 0.94
rrs 1473055 n.1210C>T non_coding_transcript_exon_variant 0.9
rrs 1473056 n.1211A>T non_coding_transcript_exon_variant 0.93
rrs 1473066 n.1221A>G non_coding_transcript_exon_variant 0.95
rrs 1473088 n.1243A>G non_coding_transcript_exon_variant 0.97
rrs 1473093 n.1248C>T non_coding_transcript_exon_variant 0.32
rrs 1473100 n.1255G>A non_coding_transcript_exon_variant 0.92
rrs 1473102 n.1257C>T non_coding_transcript_exon_variant 0.23
rrs 1473104 n.1259C>T non_coding_transcript_exon_variant 0.96
rrs 1473110 n.1265T>G non_coding_transcript_exon_variant 0.96
rrs 1473111 n.1266A>G non_coding_transcript_exon_variant 0.96
rrs 1473115 n.1270G>T non_coding_transcript_exon_variant 0.2
rrs 1473121 n.1276T>C non_coding_transcript_exon_variant 0.87
rrs 1473123 n.1278A>T non_coding_transcript_exon_variant 0.72
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.39
rrs 1473148 n.1303G>T non_coding_transcript_exon_variant 0.65
rrs 1473163 n.1318C>A non_coding_transcript_exon_variant 0.7
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.38
rrs 1473172 n.1327T>G non_coding_transcript_exon_variant 0.19
rrs 1473173 n.1328C>T non_coding_transcript_exon_variant 0.75
rrs 1473221 n.1376C>T non_coding_transcript_exon_variant 0.61
rrs 1473252 n.1407T>C non_coding_transcript_exon_variant 0.2
rrs 1473259 n.1414C>T non_coding_transcript_exon_variant 0.23
rrs 1473262 n.1417T>C non_coding_transcript_exon_variant 0.59
rrs 1473276 n.1431A>C non_coding_transcript_exon_variant 0.71
rrs 1473277 n.1432G>A non_coding_transcript_exon_variant 0.11
rrs 1473283 n.1438T>C non_coding_transcript_exon_variant 0.52
rrs 1473284 n.1439A>T non_coding_transcript_exon_variant 0.45
rrs 1473300 n.1455C>T non_coding_transcript_exon_variant 0.17
rrs 1473301 n.1456T>G non_coding_transcript_exon_variant 0.76
rrs 1473314 n.1469A>G non_coding_transcript_exon_variant 0.5
rrs 1473315 n.1470T>C non_coding_transcript_exon_variant 0.5
rrs 1473316 n.1471C>T non_coding_transcript_exon_variant 0.72
rrs 1473319 n.1474C>T non_coding_transcript_exon_variant 0.5
rrl 1473768 n.111A>G non_coding_transcript_exon_variant 0.4
rrl 1473782 n.125A>G non_coding_transcript_exon_variant 0.8
rrl 1473783 n.126A>G non_coding_transcript_exon_variant 0.8
rrl 1473788 n.131A>G non_coding_transcript_exon_variant 0.83
rrl 1473797 n.140G>T non_coding_transcript_exon_variant 0.88
rrl 1473806 n.149C>T non_coding_transcript_exon_variant 0.88
rrl 1473807 n.150T>C non_coding_transcript_exon_variant 0.88
rrl 1473811 n.154C>T non_coding_transcript_exon_variant 0.88
rrl 1473832 n.175C>T non_coding_transcript_exon_variant 0.82
rrl 1473836 n.179A>G non_coding_transcript_exon_variant 0.9
rrl 1473839 n.182G>T non_coding_transcript_exon_variant 0.9
rrl 1473840 n.183A>G non_coding_transcript_exon_variant 0.9
rrl 1473877 n.220G>A non_coding_transcript_exon_variant 0.6
rrl 1474181 n.524C>A non_coding_transcript_exon_variant 0.43
rrl 1474184 n.527C>T non_coding_transcript_exon_variant 0.6
rrl 1474197 n.540C>T non_coding_transcript_exon_variant 0.83
rrl 1474199 n.542G>C non_coding_transcript_exon_variant 0.25
rrl 1474200 n.545delT non_coding_transcript_exon_variant 0.91
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 0.88
rrl 1474264 n.607T>G non_coding_transcript_exon_variant 0.77
rrl 1474266 n.609T>C non_coding_transcript_exon_variant 0.83
rrl 1474269 n.612C>T non_coding_transcript_exon_variant 0.83
rrl 1474275 n.618T>G non_coding_transcript_exon_variant 0.83
rrl 1474282 n.625G>A non_coding_transcript_exon_variant 0.2
rrl 1474288 n.631C>T non_coding_transcript_exon_variant 0.6
rrl 1474310 n.653T>G non_coding_transcript_exon_variant 0.6
rrl 1474315 n.658A>G non_coding_transcript_exon_variant 0.27
rrl 1474326 n.669T>A non_coding_transcript_exon_variant 0.46
rrl 1474348 n.691C>T non_coding_transcript_exon_variant 0.38
rrl 1474351 n.694G>T non_coding_transcript_exon_variant 0.87
rrl 1474353 n.696A>G non_coding_transcript_exon_variant 0.87
rrl 1474355 n.698A>G non_coding_transcript_exon_variant 0.87
rrl 1474362 n.705A>G non_coding_transcript_exon_variant 0.88
rrl 1474381 n.724T>G non_coding_transcript_exon_variant 0.25
rrl 1474383 n.726G>T non_coding_transcript_exon_variant 0.25
rrl 1474387 n.730C>T non_coding_transcript_exon_variant 0.85
rrl 1474393 n.736A>G non_coding_transcript_exon_variant 0.61
rrl 1474402 n.745T>C non_coding_transcript_exon_variant 0.61
rrl 1474405 n.749delT non_coding_transcript_exon_variant 0.17
rrl 1474413 n.757_776delCCCACACGCGCATACGCGCG non_coding_transcript_exon_variant 0.8
rrl 1474437 n.781_782delAA non_coding_transcript_exon_variant 0.67
rrl 1474448 n.791T>C non_coding_transcript_exon_variant 0.8
rrl 1474467 n.810A>G non_coding_transcript_exon_variant 0.92
rrl 1474488 n.831G>T non_coding_transcript_exon_variant 0.81
rrl 1474495 n.838G>A non_coding_transcript_exon_variant 0.82
rrl 1474498 n.841G>T non_coding_transcript_exon_variant 0.82
rrl 1474505 n.848C>G non_coding_transcript_exon_variant 0.82
rrl 1474508 n.851C>T non_coding_transcript_exon_variant 0.82
rrl 1474516 n.859C>A non_coding_transcript_exon_variant 0.86
rrl 1474527 n.870T>C non_coding_transcript_exon_variant 0.71
rrl 1474529 n.872A>C non_coding_transcript_exon_variant 0.15
rrl 1474530 n.873G>A non_coding_transcript_exon_variant 0.15
rrl 1474537 n.880G>A non_coding_transcript_exon_variant 0.87
rrl 1474539 n.882C>T non_coding_transcript_exon_variant 0.16
rrl 1474540 n.883T>G non_coding_transcript_exon_variant 0.16
rrl 1474542 n.885A>G non_coding_transcript_exon_variant 0.7
rrl 1474626 n.969T>C non_coding_transcript_exon_variant 0.52
rrl 1474632 n.975G>T non_coding_transcript_exon_variant 0.55
rrl 1474634 n.977T>G non_coding_transcript_exon_variant 0.55
rrl 1474636 n.979A>C non_coding_transcript_exon_variant 0.86
rrl 1474637 n.980C>G non_coding_transcript_exon_variant 0.32
rrl 1474638 n.981C>G non_coding_transcript_exon_variant 0.86
rrl 1474643 n.986A>G non_coding_transcript_exon_variant 0.3
rrl 1474658 n.1001A>G non_coding_transcript_exon_variant 0.55
rrl 1474663 n.1006C>T non_coding_transcript_exon_variant 0.89
rrl 1474672 n.1015C>T non_coding_transcript_exon_variant 0.29
rrl 1474673 n.1016T>C non_coding_transcript_exon_variant 0.59
rrl 1474676 n.1019T>A non_coding_transcript_exon_variant 0.9
rrl 1474677 n.1020A>G non_coding_transcript_exon_variant 0.9
rrl 1474692 n.1035G>A non_coding_transcript_exon_variant 0.91
rrl 1474706 n.1049G>A non_coding_transcript_exon_variant 0.25
rrl 1474734 n.1077G>A non_coding_transcript_exon_variant 0.88
rrl 1474734 n.1077G>C non_coding_transcript_exon_variant 0.95
rrl 1474736 n.1079C>T non_coding_transcript_exon_variant 0.29
rrl 1474760 n.1103A>G non_coding_transcript_exon_variant 0.96
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.96
rrl 1474824 n.1167A>G non_coding_transcript_exon_variant 0.95
rrl 1474830 n.1173A>G non_coding_transcript_exon_variant 0.91
rrl 1474831 n.1174A>C non_coding_transcript_exon_variant 0.9
rrl 1474831 n.1174A>T non_coding_transcript_exon_variant 0.87
rrl 1474832 n.1175A>T non_coding_transcript_exon_variant 0.35
rrl 1474864 n.1207C>T non_coding_transcript_exon_variant 0.9
rrl 1474903 n.1246T>C non_coding_transcript_exon_variant 0.78
rrl 1474913 n.1256T>C non_coding_transcript_exon_variant 0.81
rrl 1474938 n.1281G>A non_coding_transcript_exon_variant 0.18
rrl 1474945 n.1288C>A non_coding_transcript_exon_variant 0.22
rrl 1475031 n.1374G>C non_coding_transcript_exon_variant 1.0
rrl 1475059 n.1403_1404insTA non_coding_transcript_exon_variant 1.0
rrl 1475062 n.1405A>T non_coding_transcript_exon_variant 1.0
rrl 1475065 n.1409_1411delCAA non_coding_transcript_exon_variant 1.0
rrl 1475080 n.1425_1426delCC non_coding_transcript_exon_variant 1.0
rrl 1475090 n.1433A>T non_coding_transcript_exon_variant 1.0
rrl 1475104 n.1447T>A non_coding_transcript_exon_variant 1.0
rrl 1475109 n.1452C>T non_coding_transcript_exon_variant 0.35
rrl 1475114 n.1457C>T non_coding_transcript_exon_variant 1.0
rrl 1475124 n.1467A>T non_coding_transcript_exon_variant 1.0
rrl 1475137 n.1480A>T non_coding_transcript_exon_variant 0.36
rrl 1475170 n.1513A>G non_coding_transcript_exon_variant 0.29
rrl 1475171 n.1514C>T non_coding_transcript_exon_variant 0.94
rrl 1475172 n.1515A>G non_coding_transcript_exon_variant 0.53
rrl 1475175 n.1518G>C non_coding_transcript_exon_variant 0.29
rrl 1475188 n.1531C>G non_coding_transcript_exon_variant 0.22
rrl 1475499 n.1842C>T non_coding_transcript_exon_variant 0.29
rrl 1475518 n.1861A>G non_coding_transcript_exon_variant 0.29
rrl 1475521 n.1864T>C non_coding_transcript_exon_variant 0.25
rrl 1475526 n.1869C>T non_coding_transcript_exon_variant 0.25
rrl 1475529 n.1872A>G non_coding_transcript_exon_variant 0.25
rrl 1475532 n.1875A>T non_coding_transcript_exon_variant 0.33
rrl 1475538 n.1881T>C non_coding_transcript_exon_variant 0.33
rrl 1475548 n.1891C>T non_coding_transcript_exon_variant 0.4
rrl 1475549 n.1892T>C non_coding_transcript_exon_variant 0.4
rrl 1475696 n.2039T>C non_coding_transcript_exon_variant 0.6
rrl 1475699 n.2042C>T non_coding_transcript_exon_variant 0.6
rrl 1475703 n.2046A>G non_coding_transcript_exon_variant 0.6
rrl 1475715 n.2058G>T non_coding_transcript_exon_variant 0.15
rrl 1475751 n.2094C>A non_coding_transcript_exon_variant 0.96
rrl 1475754 n.2097G>A non_coding_transcript_exon_variant 0.79
rrl 1475756 n.2099T>C non_coding_transcript_exon_variant 0.96
rrl 1475758 n.2101A>G non_coding_transcript_exon_variant 0.15
rrl 1475774 n.2117C>T non_coding_transcript_exon_variant 0.77
rrl 1475777 n.2120A>T non_coding_transcript_exon_variant 0.97
rrl 1475881 n.2224T>C non_coding_transcript_exon_variant 0.59
rrl 1475883 n.2226A>C non_coding_transcript_exon_variant 0.97
rrl 1475883 n.2226A>T non_coding_transcript_exon_variant 0.96
rrl 1475884 n.2227A>G non_coding_transcript_exon_variant 0.6
rrl 1475898 n.2241A>G non_coding_transcript_exon_variant 0.95
rrl 1475899 n.2242G>A non_coding_transcript_exon_variant 0.94
rrl 1475900 n.2243A>G non_coding_transcript_exon_variant 0.51
rrl 1475916 n.2259C>G non_coding_transcript_exon_variant 0.88
rrl 1475916 n.2259C>T non_coding_transcript_exon_variant 0.85
rrl 1475937 n.2280A>T non_coding_transcript_exon_variant 0.44
rrl 1475943 n.2286G>A non_coding_transcript_exon_variant 0.88
rrl 1475945 n.2288C>A non_coding_transcript_exon_variant 0.86
rrl 1475952 n.2295A>G non_coding_transcript_exon_variant 0.8
rrl 1476131 n.2474C>T non_coding_transcript_exon_variant 0.25
rrl 1476164 n.2507A>T non_coding_transcript_exon_variant 0.58
rrl 1476165 n.2508T>G non_coding_transcript_exon_variant 0.15
rrl 1476179 n.2522C>T non_coding_transcript_exon_variant 0.56
rrl 1476194 n.2537A>T non_coding_transcript_exon_variant 0.57
rrl 1476197 n.2540T>C non_coding_transcript_exon_variant 0.24
rrl 1476200 n.2543A>T non_coding_transcript_exon_variant 0.82
rrl 1476201 n.2544C>T non_coding_transcript_exon_variant 0.35
rrl 1476204 n.2547C>T non_coding_transcript_exon_variant 0.47
rrl 1476207 n.2550T>C non_coding_transcript_exon_variant 0.47
rrl 1476209 n.2552A>G non_coding_transcript_exon_variant 0.24
rrl 1476214 n.2557G>T non_coding_transcript_exon_variant 0.6
rrl 1476215 n.2558C>T non_coding_transcript_exon_variant 0.8
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.5
rrl 1476225 n.2568T>G non_coding_transcript_exon_variant 0.39
rrl 1476227 n.2570C>T non_coding_transcript_exon_variant 0.25
rrl 1476229 n.2572C>T non_coding_transcript_exon_variant 0.28
rrl 1476235 n.2578A>G non_coding_transcript_exon_variant 0.22
rrl 1476250 n.2593C>G non_coding_transcript_exon_variant 0.58
rrl 1476251 n.2594T>C non_coding_transcript_exon_variant 0.67
rrl 1476252 n.2595T>G non_coding_transcript_exon_variant 0.19
rrl 1476256 n.2599A>G non_coding_transcript_exon_variant 0.11
rrl 1476257 n.2600G>C non_coding_transcript_exon_variant 0.61
rrl 1476260 n.2603A>G non_coding_transcript_exon_variant 0.79
rrl 1476280 n.2623A>C non_coding_transcript_exon_variant 0.54
rrl 1476337 n.2680C>T non_coding_transcript_exon_variant 0.13
rrl 1476357 n.2700T>C non_coding_transcript_exon_variant 0.55
rrl 1476359 n.2702C>G non_coding_transcript_exon_variant 0.92
rrl 1476381 n.2724G>C non_coding_transcript_exon_variant 0.88
rrl 1476428 n.2771C>T non_coding_transcript_exon_variant 0.28
rrl 1476429 n.2772A>C non_coding_transcript_exon_variant 0.27
rrl 1476466 n.2809C>T non_coding_transcript_exon_variant 0.88
rrl 1476481 n.2824T>C non_coding_transcript_exon_variant 0.16
rrl 1476506 n.2849T>C non_coding_transcript_exon_variant 0.82
rrl 1476513 n.2856G>T non_coding_transcript_exon_variant 0.78
rrl 1476515 n.2858C>T non_coding_transcript_exon_variant 0.79
rrl 1476523 n.2866T>C non_coding_transcript_exon_variant 0.33
rrl 1476524 n.2867C>A non_coding_transcript_exon_variant 0.6
rrl 1476524 n.2867C>T non_coding_transcript_exon_variant 0.67
rrl 1476525 n.2868A>G non_coding_transcript_exon_variant 0.76
rrl 1476528 n.2871A>G non_coding_transcript_exon_variant 0.42
rrl 1476536 n.2879G>A non_coding_transcript_exon_variant 0.44
rrl 1476538 n.2881A>G non_coding_transcript_exon_variant 0.61
rrl 1476539 n.2882A>G non_coding_transcript_exon_variant 0.5
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.87
rrl 1476585 n.2928A>G non_coding_transcript_exon_variant 0.87
rrl 1476596 n.2939C>T non_coding_transcript_exon_variant 0.13
rrl 1476600 n.2943A>C non_coding_transcript_exon_variant 0.73
rrl 1476608 n.2951C>G non_coding_transcript_exon_variant 0.87
rrl 1476614 n.2957A>T non_coding_transcript_exon_variant 0.86
rrl 1476616 n.2959A>G non_coding_transcript_exon_variant 0.88
rrl 1476619 n.2962C>T non_coding_transcript_exon_variant 0.9
rrl 1476628 n.2971T>G non_coding_transcript_exon_variant 0.9
rrl 1476629 n.2972C>A non_coding_transcript_exon_variant 0.9
rrl 1476633 n.2976A>G non_coding_transcript_exon_variant 0.86
rrl 1476664 n.3007T>A non_coding_transcript_exon_variant 0.91
rrl 1476668 n.3011C>T non_coding_transcript_exon_variant 0.82
rrl 1476675 n.3018C>A non_coding_transcript_exon_variant 0.89
fabG1 1673922 p.Ile161Met missense_variant 0.12
inhA 1674747 c.546C>T synonymous_variant 0.22
rpsA 1833661 c.120A>G synonymous_variant 0.14
rpsA 1833667 c.126C>T synonymous_variant 0.12
rpsA 1833668 p.Ile43Val missense_variant 0.12
rpsA 1833676 c.135A>G synonymous_variant 0.12
rpsA 1833679 c.138G>C synonymous_variant 0.12
rpsA 1833685 c.144G>T synonymous_variant 0.12
rpsA 1833688 c.147C>T synonymous_variant 0.13
rpsA 1833694 c.153G>C synonymous_variant 0.14
rpsA 1833727 c.186G>C synonymous_variant 0.2
rpsA 1833732 p.Pro64Leu missense_variant 0.21
rpsA 1833736 c.195C>T synonymous_variant 0.18
rpsA 1833742 c.201A>G synonymous_variant 0.18
rpsA 1833770 p.Asn77Asp missense_variant 0.12
rpsA 1833874 c.333T>C synonymous_variant 0.14
rpsA 1833905 p.Lys122Glu missense_variant 0.17
rpsA 1833912 p.Glu124Gly missense_variant 0.18
rpsA 1833915 p.Ala125Val missense_variant 0.18
rpsA 1833921 p.Lys127Thr missense_variant 0.19
rpsA 1833926 p.Thr129Ser missense_variant 0.2
rpsA 1833949 c.408T>C synonymous_variant 0.29
rpsA 1833952 c.411C>T synonymous_variant 0.27
rpsA 1833955 c.414G>C synonymous_variant 0.27
rpsA 1833961 c.420C>G synonymous_variant 0.21
rpsA 1833994 c.453G>C synonymous_variant 0.18
rpsA 1834009 c.468C>T synonymous_variant 0.12
rpsA 1834012 c.471G>C synonymous_variant 0.12
rpsA 1834015 c.474G>T synonymous_variant 0.12
rpsA 1834024 c.483G>C synonymous_variant 0.11
rpsA 1834195 c.654G>C synonymous_variant 0.23
rpsA 1834210 c.669C>T synonymous_variant 0.26
rpsA 1834213 c.672G>C synonymous_variant 0.25
rpsA 1834219 c.678C>G synonymous_variant 0.25
rpsA 1834222 c.681T>C synonymous_variant 0.24
rpsA 1834225 c.684C>G synonymous_variant 0.25
rpsA 1834228 c.687C>T synonymous_variant 0.29
rpsA 1834231 c.690T>C synonymous_variant 0.25
rpsA 1834234 c.693G>C synonymous_variant 0.44
rpsA 1834240 c.699T>C synonymous_variant 0.28
rpsA 1834246 c.705G>C synonymous_variant 0.36
rpsA 1834249 c.708T>C synonymous_variant 0.46
rpsA 1834261 c.720A>G synonymous_variant 0.49
rpsA 1834264 c.723G>C synonymous_variant 0.49
rpsA 1834285 c.744G>C synonymous_variant 0.38
rpsA 1834294 c.753G>C synonymous_variant 0.41
rpsA 1834298 p.Gln253Glu missense_variant 0.43
rpsA 1834303 c.762T>C synonymous_variant 0.32
rpsA 1834306 c.765T>C synonymous_variant 0.19
rpsA 1834307 p.Asp256Asn missense_variant 0.33
rpsA 1834318 c.777C>G synonymous_variant 0.29
rpsA 1834327 c.786G>C synonymous_variant 0.36
rpsA 1834330 c.789C>G synonymous_variant 0.26
rpsA 1834546 p.Asp335Glu missense_variant 0.12
rpsA 1834684 c.1143C>T synonymous_variant 0.15
rpsA 1834758 p.Gly406Asp missense_variant 0.3
rpsA 1834836 p.Met432Thr missense_variant 1.0
tlyA 1917972 c.33A>G synonymous_variant 1.0
ndh 2101756 c.1287G>T synonymous_variant 0.17
katG 2155397 p.Pro239Ser missense_variant 0.12
katG 2156196 c.-85C>T upstream_gene_variant 1.0
katG 2156207 c.-96T>A upstream_gene_variant 0.18
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
kasA 2518919 p.Gly269Ser missense_variant 1.0
kasA 2519092 c.978C>T synonymous_variant 0.12
eis 2714171 p.Ala388Ser missense_variant 0.17
eis 2715317 p.Cys6Arg missense_variant 0.1
folC 2746340 p.Ala420Val missense_variant 1.0
folC 2747352 p.Asp83Asn missense_variant 0.18
ribD 2986827 c.-12G>A upstream_gene_variant 1.0
ribD 2986959 p.Leu41Met missense_variant 0.12
ribD 2987311 p.Gly158Ala missense_variant 0.18
Rv2752c 3064864 p.Pro443Leu missense_variant 0.18
Rv2752c 3066143 p.Arg17Trp missense_variant 0.29
thyX 3067612 p.Lys112Glu missense_variant 0.12
thyX 3068156 c.-211G>T upstream_gene_variant 0.12
thyA 3073868 p.Thr202Ala missense_variant 1.0
ald 3086788 c.-32T>C upstream_gene_variant 1.0
ald 3086997 p.Thr60Gly missense_variant 0.2
fprA 3473996 c.-11_-10insA upstream_gene_variant 1.0
whiB7 3568723 c.-44T>C upstream_gene_variant 0.12
alr 3840374 p.Asp349Glu missense_variant 0.11
alr 3840602 c.819G>T synonymous_variant 0.15
rpoA 3877786 p.Ala241Val missense_variant 0.33
rpoA 3878227 p.Thr94Ile missense_variant 0.17
rpoA 3878394 c.114G>A synonymous_variant 0.15
ddn 3986799 c.-45G>T upstream_gene_variant 0.18
ddn 3987000 p.Gly53Cys missense_variant 0.2
clpC1 4038169 p.Ala846Pro missense_variant 0.17
clpC1 4038287 c.2418C>T synonymous_variant 1.0
clpC1 4038793 c.1912C>T synonymous_variant 0.12
clpC1 4038794 p.Ser637Thr missense_variant 0.12
clpC1 4038806 p.Glu633Asp missense_variant 0.11
clpC1 4038810 p.Gln632Pro missense_variant 0.15
clpC1 4038815 c.1890G>T synonymous_variant 0.15
clpC1 4038821 c.1884G>A synonymous_variant 0.16
clpC1 4038826 p.Ile627Val missense_variant 0.11
clpC1 4038845 c.1860G>C synonymous_variant 0.31
clpC1 4038854 p.Lys617Arg missense_variant 0.12
clpC1 4038860 c.1845G>C synonymous_variant 0.12
clpC1 4038878 c.1827A>G synonymous_variant 0.27
clpC1 4038890 p.Glu605Asp missense_variant 0.17
clpC1 4038905 c.1800A>C synonymous_variant 0.14
clpC1 4038911 c.1794G>T synonymous_variant 0.23
clpC1 4038914 c.1791G>C synonymous_variant 0.15
clpC1 4038968 c.1737G>A synonymous_variant 1.0
clpC1 4040003 c.702G>C synonymous_variant 0.13
clpC1 4040015 p.Ala230Ser missense_variant 0.15
clpC1 4040021 c.684A>C synonymous_variant 0.15
clpC1 4040024 c.681A>G synonymous_variant 0.27
clpC1 4040045 c.660C>G synonymous_variant 0.42
clpC1 4040051 c.654C>G synonymous_variant 0.41
clpC1 4040057 c.648C>G synonymous_variant 0.44
clpC1 4040063 c.642G>C synonymous_variant 0.5
clpC1 4040066 c.639G>C synonymous_variant 0.5
clpC1 4040069 c.636G>C synonymous_variant 0.53
clpC1 4040090 c.615T>C synonymous_variant 0.57
clpC1 4040096 c.609G>C synonymous_variant 0.46
clpC1 4040110 c.595C>A synonymous_variant 0.27
clpC1 4040114 p.Ile197Met missense_variant 0.23
clpC1 4040117 c.588A>G synonymous_variant 0.2
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embA 4243192 c.-40delT upstream_gene_variant 1.0
embA 4243833 p.Ala201Pro missense_variant 0.18
embB 4246582 c.69T>C synonymous_variant 0.15
embB 4247195 p.Ala228Thr missense_variant 0.14
embB 4248334 c.1821C>A synonymous_variant 0.12
embB 4248337 c.1824G>A synonymous_variant 0.12
ethR 4327888 p.Phe114Leu missense_variant 0.18
ethA 4328337 c.-864C>A upstream_gene_variant 0.11
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
gid 4407860 c.341_342delTC frameshift_variant 0.17
gid 4408156 p.Leu16Arg missense_variant 1.0
gid 4408263 c.-61G>T upstream_gene_variant 0.18