TB-Profiler

Lineage	Family	RDs	Frequency
lineage4	Euro-American	None	1.0
lineage4.8	Euro-American (mainly T)	RD219	1.0

Gene	Chromosome position	Mutation	Type	Estimated fraction	Drugs	Confidence	Comment
rrs	1473247	n.1402C>A	non_coding_transcript_exon_variant	0.69	amikacin	Uncertain significance	Mutation from literature
capreomycin	Uncertain significance	Mutation from literature
kanamycin	Uncertain significance	Mutation from literature
rrs	1473329	n.1484G>T	non_coding_transcript_exon_variant	0.62	kanamycin	Assoc w R
amikacin	Assoc w R
capreomycin	Assoc w R

Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance

Gene	Chromosome position	Mutation	Type	Estimated fraction	Drugs	Confidence
gyrA	7362	p.Glu21Gln	missense_variant	1.0	levofloxacin	Not assoc w R
gyrA	7362	p.Glu21Gln	missense_variant	1.0	moxifloxacin	Not assoc w R
Rv0565c	656265	c.1204_1205delAC	frameshift_variant	1.0	ethionamide	Uncertain significance
nusG	734658	c.405A>G	synonymous_variant	1.0	rifampicin	Not assoc w R
rpoB	762929	c.3123G>C	synonymous_variant	0.17	rifampicin	Not assoc w R - Interim
rpoC	762959	c.-411G>T	upstream_gene_variant	0.17	rifampicin
rpoC	762971	c.-399G>C	upstream_gene_variant	0.18	rifampicin
rpoC	762983	c.-387C>T	upstream_gene_variant	0.17	rifampicin
mmpL5	775639	p.Ile948Val	missense_variant	0.98	clofazimine	Not assoc w R
mmpL5	775639	p.Ile948Val	missense_variant	0.98	bedaquiline	Not assoc w R - Interim
rpsL	781275	c.-285A>C	upstream_gene_variant	1.0	streptomycin
rpsL	781395	c.-165T>C	upstream_gene_variant	1.0	streptomycin	Not assoc w R
rrs	1471659	n.-187C>T	upstream_gene_variant	1.0	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472085	n.240C>T	non_coding_transcript_exon_variant	0.2	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472106	n.261G>A	non_coding_transcript_exon_variant	0.23	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1472107	n.262A>G	non_coding_transcript_exon_variant	0.23	streptomycin
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472108	n.263C>T	non_coding_transcript_exon_variant	0.23	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472112	n.267C>T	non_coding_transcript_exon_variant	0.24	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472122	n.277G>T	non_coding_transcript_exon_variant	0.24	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472123	n.278A>T	non_coding_transcript_exon_variant	0.24	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472124	n.279C>T	non_coding_transcript_exon_variant	0.24	streptomycin
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472150	n.305T>A	non_coding_transcript_exon_variant	0.4	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Not assoc w R
					amikacin	Not assoc w R
rrs	1472160	n.315C>T	non_coding_transcript_exon_variant	0.5	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472225	n.380C>G	non_coding_transcript_exon_variant	0.58	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472240	n.395G>A	non_coding_transcript_exon_variant	0.58	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472251	n.406G>C	non_coding_transcript_exon_variant	0.59	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472279	n.434T>G	non_coding_transcript_exon_variant	0.59	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472285	n.440A>G	non_coding_transcript_exon_variant	0.59	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472288	n.443A>T	non_coding_transcript_exon_variant	0.59	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472289	n.444T>G	non_coding_transcript_exon_variant	0.59	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472290	n.445C>T	non_coding_transcript_exon_variant	0.59	streptomycin
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472298	n.453_467delGTCCGGGTTCTCTCGinsCGT	non_coding_transcript_exon_variant	0.64	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472315	n.470T>G	non_coding_transcript_exon_variant	0.63	streptomycin
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472324	n.479G>A	non_coding_transcript_exon_variant	0.63	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472325	n.480G>T	non_coding_transcript_exon_variant	0.62	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472326	n.481T>G	non_coding_transcript_exon_variant	0.62	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472329	n.484A>T	non_coding_transcript_exon_variant	0.63	streptomycin	Uncertain significance
					kanamycin
					capreomycin
					amikacin
rrs	1472330	n.485G>A	non_coding_transcript_exon_variant	0.63	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472344	n.499C>T	non_coding_transcript_exon_variant	0.69	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Not assoc w R
					amikacin	Not assoc w R
rrs	1472368	n.523A>G	non_coding_transcript_exon_variant	0.76	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472396	n.551A>T	non_coding_transcript_exon_variant	0.75	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472400	n.555C>T	non_coding_transcript_exon_variant	0.74	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Not assoc w R
					amikacin	Not assoc w R
rrs	1472412	n.567A>G	non_coding_transcript_exon_variant	0.72	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472427	n.582T>G	non_coding_transcript_exon_variant	0.67	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472428	n.583G>A	non_coding_transcript_exon_variant	0.66	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472435	n.590T>C	non_coding_transcript_exon_variant	0.66	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472437	n.592T>G	non_coding_transcript_exon_variant	0.68	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472438	n.593T>A	non_coding_transcript_exon_variant	0.68	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472439	n.594C>A	non_coding_transcript_exon_variant	0.68	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472443	n.598A>T	non_coding_transcript_exon_variant	0.68	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472449	n.604C>T	non_coding_transcript_exon_variant	0.69	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472450	n.605A>G	non_coding_transcript_exon_variant	0.7	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472451	n.606C>G	non_coding_transcript_exon_variant	0.7	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472460	n.615T>C	non_coding_transcript_exon_variant	0.68	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472461	n.616G>C	non_coding_transcript_exon_variant	0.68	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472471	n.626G>T	non_coding_transcript_exon_variant	0.69	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472472	n.627G>T	non_coding_transcript_exon_variant	0.7	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472473	n.628G>T	non_coding_transcript_exon_variant	0.69	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472483	n.638C>T	non_coding_transcript_exon_variant	0.69	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472484	n.639A>T	non_coding_transcript_exon_variant	0.7	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472489	n.644A>T	non_coding_transcript_exon_variant	0.7	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472493	n.648T>G	non_coding_transcript_exon_variant	0.7	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472495	n.650C>A	non_coding_transcript_exon_variant	0.69	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472496	n.651T>G	non_coding_transcript_exon_variant	0.7	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472498	n.653C>T	non_coding_transcript_exon_variant	0.71	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472507	n.662C>A	non_coding_transcript_exon_variant	0.76	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472522	n.677T>G	non_coding_transcript_exon_variant	0.8	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472557	n.712G>A	non_coding_transcript_exon_variant	0.79	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472571	n.726G>T	non_coding_transcript_exon_variant	0.79	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472581	n.736A>C	non_coding_transcript_exon_variant	0.79	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472582	n.737G>T	non_coding_transcript_exon_variant	0.79	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472584	n.739A>T	non_coding_transcript_exon_variant	0.79	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472585	n.740A>C	non_coding_transcript_exon_variant	0.79	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472623	n.778A>C	non_coding_transcript_exon_variant	0.77	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472647	n.802C>T	non_coding_transcript_exon_variant	0.78	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472673	n.828T>G	non_coding_transcript_exon_variant	0.79	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472675	n.830T>C	non_coding_transcript_exon_variant	0.79	streptomycin
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472677	n.832C>A	non_coding_transcript_exon_variant	0.79	streptomycin
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472682	n.837T>A	non_coding_transcript_exon_variant	0.79	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472683	n.838T>C	non_coding_transcript_exon_variant	0.79	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472687	n.842A>T	non_coding_transcript_exon_variant	0.79	streptomycin
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472707	n.862A>T	non_coding_transcript_exon_variant	0.81	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472767	n.922G>C	non_coding_transcript_exon_variant	0.84	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472790	n.945T>C	non_coding_transcript_exon_variant	0.81	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472812	n.967A>T	non_coding_transcript_exon_variant	0.79	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472837	n.992C>G	non_coding_transcript_exon_variant	0.69	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472839	n.994_995delCAinsTCG	non_coding_transcript_exon_variant	0.69	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472843	n.999_1001delCGC	non_coding_transcript_exon_variant	0.69	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472849	n.1004_1005delCTinsGCTC	non_coding_transcript_exon_variant	0.68	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472857	n.1012A>G	non_coding_transcript_exon_variant	0.68	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472860	n.1015C>T	non_coding_transcript_exon_variant	0.68	streptomycin
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472862	n.1017_1018insGCC	non_coding_transcript_exon_variant	0.68	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472865	n.1020C>T	non_coding_transcript_exon_variant	0.67	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472866	n.1021C>T	non_coding_transcript_exon_variant	0.67	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472870	n.1025T>G	non_coding_transcript_exon_variant	0.66	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472873	n.1028C>T	non_coding_transcript_exon_variant	0.66	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472875	n.1030T>G	non_coding_transcript_exon_variant	0.69	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472878	n.1033G>T	non_coding_transcript_exon_variant	0.7	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472879	n.1034T>C	non_coding_transcript_exon_variant	0.7	streptomycin	Uncertain significance
					kanamycin
					capreomycin
					amikacin
rrs	1472880	n.1035G>A	non_coding_transcript_exon_variant	0.7	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472954	n.1110delC	non_coding_transcript_exon_variant	0.74	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472958	n.1113_1114insC	non_coding_transcript_exon_variant	0.75	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472973	n.1128A>T	non_coding_transcript_exon_variant	0.79	streptomycin
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472986	n.1141_1142insA	non_coding_transcript_exon_variant	0.77	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472989	n.1145delA	non_coding_transcript_exon_variant	0.77	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472996	n.1151T>C	non_coding_transcript_exon_variant	0.8	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473066	n.1221A>G	non_coding_transcript_exon_variant	0.82	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473081	n.1236C>T	non_coding_transcript_exon_variant	0.78	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473088	n.1243A>G	non_coding_transcript_exon_variant	0.75	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473091	n.1246G>A	non_coding_transcript_exon_variant	0.73	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473093	n.1248C>T	non_coding_transcript_exon_variant	0.73	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473094	n.1249T>G	non_coding_transcript_exon_variant	0.73	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1473099	n.1254T>G	non_coding_transcript_exon_variant	0.73	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473100	n.1255G>C	non_coding_transcript_exon_variant	0.73	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1473102	n.1257C>T	non_coding_transcript_exon_variant	0.74	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473104	n.1259C>T	non_coding_transcript_exon_variant	0.74	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473109	n.1264T>G	non_coding_transcript_exon_variant	0.73	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1473111	n.1266A>G	non_coding_transcript_exon_variant	0.73	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473120	n.1275C>T	non_coding_transcript_exon_variant	0.73	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473121	n.1276T>C	non_coding_transcript_exon_variant	0.74	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Not assoc w R
					amikacin	Not assoc w R
rrs	1473122	n.1277T>G	non_coding_transcript_exon_variant	0.73	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1473123	n.1278A>G	non_coding_transcript_exon_variant	0.74	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473145	n.1300C>T	non_coding_transcript_exon_variant	0.78	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473164	n.1319C>T	non_coding_transcript_exon_variant	0.78	streptomycin	Uncertain significance
					kanamycin
					capreomycin
					amikacin
rrs	1473166	n.1321G>A	non_coding_transcript_exon_variant	0.78	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473226	n.1381C>G	non_coding_transcript_exon_variant	0.71	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1473259	n.1414C>T	non_coding_transcript_exon_variant	0.69	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1473276	n.1431A>G	non_coding_transcript_exon_variant	0.65	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473288	n.1443C>G	non_coding_transcript_exon_variant	0.62	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473290	n.1445C>T	non_coding_transcript_exon_variant	0.62	streptomycin
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473292	n.1447G>T	non_coding_transcript_exon_variant	0.62	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1473294	n.1449A>G	non_coding_transcript_exon_variant	0.63	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473301	n.1456T>C	non_coding_transcript_exon_variant	0.63	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473315	n.1470T>C	non_coding_transcript_exon_variant	0.62	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473316	n.1471C>T	non_coding_transcript_exon_variant	0.61	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473319	n.1474C>T	non_coding_transcript_exon_variant	0.62	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473324	n.1479G>A	non_coding_transcript_exon_variant	0.62	streptomycin
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin
rrl	1474001	n.344C>T	non_coding_transcript_exon_variant	1.0	capreomycin	Not assoc w R
rrl	1474001	n.344C>T	non_coding_transcript_exon_variant	1.0	linezolid	Not assoc w R
rrl	1474202	n.545T>G	non_coding_transcript_exon_variant	0.19	capreomycin
rrl	1474202	n.545T>G	non_coding_transcript_exon_variant	0.19	linezolid
rrl	1474218	n.561T>G	non_coding_transcript_exon_variant	0.23	capreomycin
rrl	1474218	n.561T>G	non_coding_transcript_exon_variant	0.23	linezolid
rrl	1474253	n.596A>T	non_coding_transcript_exon_variant	0.23	capreomycin	Uncertain significance
rrl	1474253	n.596A>T	non_coding_transcript_exon_variant	0.23	linezolid	Uncertain significance
rrl	1474348	n.691C>T	non_coding_transcript_exon_variant	0.18	capreomycin	Uncertain significance
rrl	1474348	n.691C>T	non_coding_transcript_exon_variant	0.18	linezolid	Uncertain significance
rrl	1474351	n.694G>T	non_coding_transcript_exon_variant	0.16	capreomycin	Uncertain significance
rrl	1474351	n.694G>T	non_coding_transcript_exon_variant	0.16	linezolid	Uncertain significance
rrl	1474476	n.819C>T	non_coding_transcript_exon_variant	0.18	capreomycin
rrl	1474476	n.819C>T	non_coding_transcript_exon_variant	0.18	linezolid
rrl	1474488	n.831G>A	non_coding_transcript_exon_variant	0.24	capreomycin
rrl	1474488	n.831G>A	non_coding_transcript_exon_variant	0.24	linezolid
rrl	1474496	n.839C>T	non_coding_transcript_exon_variant	0.26	capreomycin
rrl	1474496	n.839C>T	non_coding_transcript_exon_variant	0.26	linezolid
rrl	1474497	n.840G>C	non_coding_transcript_exon_variant	0.26	capreomycin	Uncertain significance
rrl	1474497	n.840G>C	non_coding_transcript_exon_variant	0.26	linezolid	Uncertain significance
rrl	1474506	n.849C>G	non_coding_transcript_exon_variant	0.27	capreomycin	Uncertain significance
rrl	1474506	n.849C>G	non_coding_transcript_exon_variant	0.27	linezolid	Uncertain significance
rrl	1474507	n.850G>T	non_coding_transcript_exon_variant	0.3	capreomycin	Uncertain significance
rrl	1474507	n.850G>T	non_coding_transcript_exon_variant	0.3	linezolid	Uncertain significance
rrl	1474516	n.859C>T	non_coding_transcript_exon_variant	0.37	capreomycin
rrl	1474516	n.859C>T	non_coding_transcript_exon_variant	0.37	linezolid
rrl	1474529	n.872A>C	non_coding_transcript_exon_variant	0.37	capreomycin
rrl	1474529	n.872A>C	non_coding_transcript_exon_variant	0.37	linezolid
rrl	1474530	n.873G>A	non_coding_transcript_exon_variant	0.37	capreomycin
rrl	1474530	n.873G>A	non_coding_transcript_exon_variant	0.37	linezolid
rrl	1474537	n.880G>A	non_coding_transcript_exon_variant	0.38	capreomycin	Uncertain significance
rrl	1474537	n.880G>A	non_coding_transcript_exon_variant	0.38	linezolid	Uncertain significance
rrl	1474539	n.882C>T	non_coding_transcript_exon_variant	0.38	capreomycin
rrl	1474539	n.882C>T	non_coding_transcript_exon_variant	0.38	linezolid
rrl	1474540	n.883T>G	non_coding_transcript_exon_variant	0.38	capreomycin
rrl	1474540	n.883T>G	non_coding_transcript_exon_variant	0.38	linezolid
rrl	1474552	n.895C>T	non_coding_transcript_exon_variant	0.51	capreomycin
rrl	1474552	n.895C>T	non_coding_transcript_exon_variant	0.51	linezolid
rrl	1474558	n.901G>A	non_coding_transcript_exon_variant	0.52	capreomycin	Uncertain significance
rrl	1474558	n.901G>A	non_coding_transcript_exon_variant	0.52	linezolid
rrl	1474582	n.925T>A	non_coding_transcript_exon_variant	0.63	capreomycin
rrl	1474582	n.925T>A	non_coding_transcript_exon_variant	0.63	linezolid
rrl	1474636	n.979A>T	non_coding_transcript_exon_variant	0.64	capreomycin	Uncertain significance
rrl	1474636	n.979A>T	non_coding_transcript_exon_variant	0.64	linezolid
rrl	1474637	n.980C>T	non_coding_transcript_exon_variant	0.63	capreomycin	Uncertain significance
rrl	1474637	n.980C>T	non_coding_transcript_exon_variant	0.63	linezolid
rrl	1474638	n.981C>G	non_coding_transcript_exon_variant	0.64	capreomycin	Uncertain significance
rrl	1474638	n.981C>G	non_coding_transcript_exon_variant	0.64	linezolid	Uncertain significance
rrl	1474639	n.982G>T	non_coding_transcript_exon_variant	0.64	capreomycin	Uncertain significance
rrl	1474639	n.982G>T	non_coding_transcript_exon_variant	0.64	linezolid
rrl	1474640	n.983C>T	non_coding_transcript_exon_variant	0.63	capreomycin	Uncertain significance
rrl	1474640	n.983C>T	non_coding_transcript_exon_variant	0.63	linezolid
rrl	1474651	n.995delT	non_coding_transcript_exon_variant	0.62	capreomycin
rrl	1474651	n.995delT	non_coding_transcript_exon_variant	0.62	linezolid
rrl	1474662	n.1005C>T	non_coding_transcript_exon_variant	0.62	capreomycin
rrl	1474662	n.1005C>T	non_coding_transcript_exon_variant	0.62	linezolid
rrl	1474664	n.1007G>T	non_coding_transcript_exon_variant	0.62	capreomycin	Uncertain significance
rrl	1474664	n.1007G>T	non_coding_transcript_exon_variant	0.62	linezolid	Uncertain significance
rrl	1474666	n.1009T>G	non_coding_transcript_exon_variant	0.61	capreomycin	Uncertain significance
rrl	1474666	n.1009T>G	non_coding_transcript_exon_variant	0.61	linezolid	Uncertain significance
rrl	1474670	n.1013C>G	non_coding_transcript_exon_variant	0.61	capreomycin	Uncertain significance
rrl	1474670	n.1013C>G	non_coding_transcript_exon_variant	0.61	linezolid	Uncertain significance
rrl	1474672	n.1015C>T	non_coding_transcript_exon_variant	0.6	capreomycin	Uncertain significance
rrl	1474672	n.1015C>T	non_coding_transcript_exon_variant	0.6	linezolid	Uncertain significance
rrl	1474675	n.1018C>T	non_coding_transcript_exon_variant	0.59	capreomycin
rrl	1474675	n.1018C>T	non_coding_transcript_exon_variant	0.59	linezolid
rrl	1474676	n.1019T>C	non_coding_transcript_exon_variant	0.6	capreomycin	Uncertain significance
rrl	1474676	n.1019T>C	non_coding_transcript_exon_variant	0.6	linezolid	Uncertain significance
rrl	1474677	n.1020A>G	non_coding_transcript_exon_variant	0.6	capreomycin	Uncertain significance
rrl	1474677	n.1020A>G	non_coding_transcript_exon_variant	0.6	linezolid	Uncertain significance
rrl	1474679	n.1022G>C	non_coding_transcript_exon_variant	0.59	capreomycin	Uncertain significance
rrl	1474679	n.1022G>C	non_coding_transcript_exon_variant	0.59	linezolid	Uncertain significance
rrl	1474684	n.1027T>C	non_coding_transcript_exon_variant	0.62	capreomycin	Uncertain significance
rrl	1474684	n.1027T>C	non_coding_transcript_exon_variant	0.62	linezolid	Uncertain significance
rrl	1474687	n.1030C>A	non_coding_transcript_exon_variant	0.62	capreomycin	Uncertain significance
rrl	1474687	n.1030C>A	non_coding_transcript_exon_variant	0.62	linezolid	Uncertain significance
rrl	1474688	n.1031G>A	non_coding_transcript_exon_variant	0.62	capreomycin
rrl	1474688	n.1031G>A	non_coding_transcript_exon_variant	0.62	linezolid
rrl	1474707	n.1051_1052delCG	non_coding_transcript_exon_variant	0.65	capreomycin
rrl	1474707	n.1051_1052delCG	non_coding_transcript_exon_variant	0.65	linezolid
rrl	1474711	n.1055_1056insCAAG	non_coding_transcript_exon_variant	0.64	capreomycin
rrl	1474711	n.1055_1056insCAAG	non_coding_transcript_exon_variant	0.64	linezolid
rrl	1474715	n.1060_1061delAA	non_coding_transcript_exon_variant	0.66	capreomycin
rrl	1474715	n.1060_1061delAA	non_coding_transcript_exon_variant	0.66	linezolid
rrl	1474749	n.1092C>T	non_coding_transcript_exon_variant	0.68	capreomycin	Uncertain significance
rrl	1474749	n.1092C>T	non_coding_transcript_exon_variant	0.68	linezolid	Uncertain significance
rrl	1474752	n.1096delA	non_coding_transcript_exon_variant	0.69	capreomycin
rrl	1474752	n.1096delA	non_coding_transcript_exon_variant	0.69	linezolid
rrl	1474760	n.1103A>G	non_coding_transcript_exon_variant	0.7	capreomycin	Uncertain significance
rrl	1474760	n.1103A>G	non_coding_transcript_exon_variant	0.7	linezolid	Uncertain significance
rrl	1474779	n.1122G>A	non_coding_transcript_exon_variant	0.67	capreomycin	Uncertain significance
rrl	1474779	n.1122G>A	non_coding_transcript_exon_variant	0.67	linezolid	Uncertain significance
rrl	1474780	n.1123C>T	non_coding_transcript_exon_variant	0.66	capreomycin	Uncertain significance
rrl	1474780	n.1123C>T	non_coding_transcript_exon_variant	0.66	linezolid	Uncertain significance
rrl	1474782	n.1125G>A	non_coding_transcript_exon_variant	0.66	capreomycin	Not assoc w R
rrl	1474782	n.1125G>A	non_coding_transcript_exon_variant	0.66	linezolid	Uncertain significance
rrl	1474794	n.1137C>T	non_coding_transcript_exon_variant	0.61	capreomycin	Uncertain significance
rrl	1474794	n.1137C>T	non_coding_transcript_exon_variant	0.61	linezolid	Uncertain significance
rrl	1474798	n.1141C>T	non_coding_transcript_exon_variant	0.6	capreomycin	Uncertain significance
rrl	1474798	n.1141C>T	non_coding_transcript_exon_variant	0.6	linezolid	Uncertain significance
rrl	1474799	n.1143delT	non_coding_transcript_exon_variant	0.6	capreomycin
rrl	1474799	n.1143delT	non_coding_transcript_exon_variant	0.6	linezolid
rrl	1474803	n.1146_1147insA	non_coding_transcript_exon_variant	0.6	capreomycin
rrl	1474803	n.1146_1147insA	non_coding_transcript_exon_variant	0.6	linezolid
rrl	1474806	n.1149A>C	non_coding_transcript_exon_variant	0.59	capreomycin
rrl	1474806	n.1149A>C	non_coding_transcript_exon_variant	0.59	linezolid
rrl	1474823	n.1166C>G	non_coding_transcript_exon_variant	0.59	capreomycin	Uncertain significance
rrl	1474823	n.1166C>G	non_coding_transcript_exon_variant	0.59	linezolid	Uncertain significance
rrl	1474827	n.1170C>T	non_coding_transcript_exon_variant	0.59	capreomycin	Uncertain significance
rrl	1474827	n.1170C>T	non_coding_transcript_exon_variant	0.59	linezolid	Uncertain significance
rrl	1474830	n.1173A>G	non_coding_transcript_exon_variant	0.59	capreomycin	Uncertain significance
rrl	1474830	n.1173A>G	non_coding_transcript_exon_variant	0.59	linezolid	Uncertain significance
rrl	1474831	n.1174A>T	non_coding_transcript_exon_variant	0.59	capreomycin	Uncertain significance
rrl	1474831	n.1174A>T	non_coding_transcript_exon_variant	0.59	linezolid	Uncertain significance
rrl	1474853	n.1196A>G	non_coding_transcript_exon_variant	0.52	capreomycin
rrl	1474853	n.1196A>G	non_coding_transcript_exon_variant	0.52	linezolid
rrl	1474864	n.1207C>T	non_coding_transcript_exon_variant	0.45	capreomycin	Not assoc w R
rrl	1474864	n.1207C>T	non_coding_transcript_exon_variant	0.45	linezolid	Uncertain significance
rrl	1474904	n.1247G>C	non_coding_transcript_exon_variant	0.21	capreomycin	Uncertain significance
rrl	1474904	n.1247G>C	non_coding_transcript_exon_variant	0.21	linezolid	Uncertain significance
rrl	1474905	n.1248T>C	non_coding_transcript_exon_variant	0.21	capreomycin	Uncertain significance
rrl	1474905	n.1248T>C	non_coding_transcript_exon_variant	0.21	linezolid	Uncertain significance
rrl	1475673	n.2016T>C	non_coding_transcript_exon_variant	0.4	capreomycin	Uncertain significance
rrl	1475673	n.2016T>C	non_coding_transcript_exon_variant	0.4	linezolid	Uncertain significance
rrl	1475699	n.2042C>T	non_coding_transcript_exon_variant	0.56	capreomycin	Uncertain significance
rrl	1475699	n.2042C>T	non_coding_transcript_exon_variant	0.56	linezolid	Uncertain significance
rrl	1475722	n.2065G>T	non_coding_transcript_exon_variant	0.68	capreomycin
rrl	1475722	n.2065G>T	non_coding_transcript_exon_variant	0.68	linezolid
rrl	1475747	n.2090A>G	non_coding_transcript_exon_variant	0.67	capreomycin	Uncertain significance
rrl	1475747	n.2090A>G	non_coding_transcript_exon_variant	0.67	linezolid	Uncertain significance
rrl	1475751	n.2094C>A	non_coding_transcript_exon_variant	0.67	capreomycin
rrl	1475751	n.2094C>A	non_coding_transcript_exon_variant	0.67	linezolid
rrl	1475753	n.2096C>T	non_coding_transcript_exon_variant	0.66	capreomycin	Uncertain significance
rrl	1475753	n.2096C>T	non_coding_transcript_exon_variant	0.66	linezolid
rrl	1475756	n.2099_2107delTAACCCGCAinsG	non_coding_transcript_exon_variant	0.68	capreomycin
rrl	1475756	n.2099_2107delTAACCCGCAinsG	non_coding_transcript_exon_variant	0.68	linezolid
rrl	1475767	n.2110G>T	non_coding_transcript_exon_variant	0.68	capreomycin
rrl	1475767	n.2110G>T	non_coding_transcript_exon_variant	0.68	linezolid	Uncertain significance
rrl	1475770	n.2113_2114delGAinsATGCGT	non_coding_transcript_exon_variant	0.68	capreomycin
rrl	1475770	n.2113_2114delGAinsATGCGT	non_coding_transcript_exon_variant	0.68	linezolid
rrl	1475777	n.2120A>T	non_coding_transcript_exon_variant	0.71	capreomycin
rrl	1475777	n.2120A>T	non_coding_transcript_exon_variant	0.71	linezolid
rrl	1475781	n.2124T>C	non_coding_transcript_exon_variant	0.7	capreomycin	Uncertain significance
rrl	1475781	n.2124T>C	non_coding_transcript_exon_variant	0.7	linezolid
rrl	1475869	n.2212C>A	non_coding_transcript_exon_variant	0.66	capreomycin
rrl	1475869	n.2212C>A	non_coding_transcript_exon_variant	0.66	linezolid
rrl	1475877	n.2220C>T	non_coding_transcript_exon_variant	0.62	capreomycin	Uncertain significance
rrl	1475877	n.2220C>T	non_coding_transcript_exon_variant	0.62	linezolid
rrl	1475881	n.2224T>C	non_coding_transcript_exon_variant	0.61	capreomycin
rrl	1475881	n.2224T>C	non_coding_transcript_exon_variant	0.61	linezolid
rrl	1475883	n.2226A>T	non_coding_transcript_exon_variant	0.61	capreomycin	Uncertain significance
rrl	1475883	n.2226A>T	non_coding_transcript_exon_variant	0.61	linezolid	Uncertain significance
rrl	1475892	n.2235A>C	non_coding_transcript_exon_variant	0.61	capreomycin
rrl	1475892	n.2235A>C	non_coding_transcript_exon_variant	0.61	linezolid
rrl	1475898	n.2241A>G	non_coding_transcript_exon_variant	0.6	capreomycin	Uncertain significance
rrl	1475898	n.2241A>G	non_coding_transcript_exon_variant	0.6	linezolid
rrl	1475899	n.2242G>A	non_coding_transcript_exon_variant	0.6	capreomycin	Uncertain significance
rrl	1475899	n.2242G>A	non_coding_transcript_exon_variant	0.6	linezolid
rrl	1475906	n.2249C>T	non_coding_transcript_exon_variant	0.63	capreomycin	Uncertain significance
rrl	1475906	n.2249C>T	non_coding_transcript_exon_variant	0.63	linezolid	Uncertain significance
rrl	1475916	n.2259C>T	non_coding_transcript_exon_variant	0.63	capreomycin	Uncertain significance
rrl	1475916	n.2259C>T	non_coding_transcript_exon_variant	0.63	linezolid	Uncertain significance
rrl	1475943	n.2286G>A	non_coding_transcript_exon_variant	0.65	capreomycin	Uncertain significance
rrl	1475943	n.2286G>A	non_coding_transcript_exon_variant	0.65	linezolid	Uncertain significance
rrl	1475952	n.2295A>G	non_coding_transcript_exon_variant	0.64	capreomycin	Uncertain significance
rrl	1475952	n.2295A>G	non_coding_transcript_exon_variant	0.64	linezolid	Uncertain significance
rrl	1475970	n.2313C>T	non_coding_transcript_exon_variant	0.6	capreomycin	Uncertain significance
rrl	1475970	n.2313C>T	non_coding_transcript_exon_variant	0.6	linezolid	Uncertain significance
rrl	1475975	n.2318C>T	non_coding_transcript_exon_variant	0.59	capreomycin	Uncertain significance
rrl	1475975	n.2318C>T	non_coding_transcript_exon_variant	0.59	linezolid	Uncertain significance
rrl	1475977	n.2320A>G	non_coding_transcript_exon_variant	0.55	capreomycin	Uncertain significance
rrl	1475977	n.2320A>G	non_coding_transcript_exon_variant	0.55	linezolid	Uncertain significance
rrl	1475978	n.2321C>T	non_coding_transcript_exon_variant	0.55	capreomycin	Uncertain significance
rrl	1475978	n.2321C>T	non_coding_transcript_exon_variant	0.55	linezolid	Uncertain significance
rrl	1475988	n.2331A>G	non_coding_transcript_exon_variant	0.53	capreomycin	Not assoc w R
rrl	1475988	n.2331A>G	non_coding_transcript_exon_variant	0.53	linezolid	Uncertain significance
rrl	1475991	n.2334T>A	non_coding_transcript_exon_variant	0.51	capreomycin
rrl	1475991	n.2334T>A	non_coding_transcript_exon_variant	0.51	linezolid
rrl	1475993	n.2336C>T	non_coding_transcript_exon_variant	0.5	capreomycin	Uncertain significance
rrl	1475993	n.2336C>T	non_coding_transcript_exon_variant	0.5	linezolid	Uncertain significance
rrl	1475996	n.2339T>G	non_coding_transcript_exon_variant	0.49	capreomycin
rrl	1475996	n.2339T>G	non_coding_transcript_exon_variant	0.49	linezolid
rrl	1476024	n.2367T>G	non_coding_transcript_exon_variant	0.21	capreomycin
rrl	1476024	n.2367T>G	non_coding_transcript_exon_variant	0.21	linezolid
rrl	1476115	n.2458T>C	non_coding_transcript_exon_variant	0.41	capreomycin	Uncertain significance
rrl	1476115	n.2458T>C	non_coding_transcript_exon_variant	0.41	linezolid	Uncertain significance
rrl	1476117	n.2460G>A	non_coding_transcript_exon_variant	0.43	capreomycin
rrl	1476117	n.2460G>A	non_coding_transcript_exon_variant	0.43	linezolid
rrl	1476130	n.2473G>A	non_coding_transcript_exon_variant	0.58	capreomycin	Uncertain significance
rrl	1476130	n.2473G>A	non_coding_transcript_exon_variant	0.58	linezolid	Uncertain significance
rrl	1476131	n.2474C>T	non_coding_transcript_exon_variant	0.59	capreomycin	Uncertain significance
rrl	1476131	n.2474C>T	non_coding_transcript_exon_variant	0.59	linezolid	Uncertain significance
rrl	1476141	n.2484A>G	non_coding_transcript_exon_variant	0.62	capreomycin	Uncertain significance
rrl	1476141	n.2484A>G	non_coding_transcript_exon_variant	0.62	linezolid	Uncertain significance
rrl	1476153	n.2496T>C	non_coding_transcript_exon_variant	0.67	capreomycin	Uncertain significance
rrl	1476153	n.2496T>C	non_coding_transcript_exon_variant	0.67	linezolid	Uncertain significance
rrl	1476164	n.2507A>G	non_coding_transcript_exon_variant	0.7	capreomycin	Uncertain significance
rrl	1476164	n.2507A>G	non_coding_transcript_exon_variant	0.7	linezolid	Uncertain significance
rrl	1476165	n.2508T>G	non_coding_transcript_exon_variant	0.7	capreomycin	Not assoc w R
rrl	1476165	n.2508T>G	non_coding_transcript_exon_variant	0.7	linezolid	Uncertain significance
rrl	1476194	n.2537A>G	non_coding_transcript_exon_variant	0.79	capreomycin	Not assoc w R
rrl	1476194	n.2537A>G	non_coding_transcript_exon_variant	0.79	linezolid	Uncertain significance
rrl	1476200	n.2543A>T	non_coding_transcript_exon_variant	0.79	capreomycin	Not assoc w R
rrl	1476200	n.2543A>T	non_coding_transcript_exon_variant	0.79	linezolid	Uncertain significance
rrl	1476201	n.2544C>T	non_coding_transcript_exon_variant	0.79	capreomycin	Not assoc w R
rrl	1476201	n.2544C>T	non_coding_transcript_exon_variant	0.79	linezolid	Uncertain significance
rrl	1476204	n.2547C>T	non_coding_transcript_exon_variant	0.81	capreomycin
rrl	1476204	n.2547C>T	non_coding_transcript_exon_variant	0.81	linezolid
rrl	1476215	n.2558C>T	non_coding_transcript_exon_variant	0.84	capreomycin	Uncertain significance
rrl	1476215	n.2558C>T	non_coding_transcript_exon_variant	0.84	linezolid	Uncertain significance
rrl	1476224	n.2567A>G	non_coding_transcript_exon_variant	0.83	capreomycin	Uncertain significance
rrl	1476224	n.2567A>G	non_coding_transcript_exon_variant	0.83	linezolid	Uncertain significance
rrl	1476235	n.2578A>G	non_coding_transcript_exon_variant	0.82	capreomycin
rrl	1476235	n.2578A>G	non_coding_transcript_exon_variant	0.82	linezolid
rrl	1476245	n.2588C>T	non_coding_transcript_exon_variant	0.82	capreomycin	Uncertain significance
rrl	1476245	n.2588C>T	non_coding_transcript_exon_variant	0.82	linezolid	Uncertain significance
rrl	1476252	n.2595T>G	non_coding_transcript_exon_variant	0.82	capreomycin	Uncertain significance
rrl	1476252	n.2595T>G	non_coding_transcript_exon_variant	0.82	linezolid	Uncertain significance
rrl	1476256	n.2599A>G	non_coding_transcript_exon_variant	0.82	capreomycin	Uncertain significance
rrl	1476256	n.2599A>G	non_coding_transcript_exon_variant	0.82	linezolid	Uncertain significance
rrl	1476260	n.2603A>G	non_coding_transcript_exon_variant	0.82	capreomycin	Not assoc w R
rrl	1476260	n.2603A>G	non_coding_transcript_exon_variant	0.82	linezolid	Uncertain significance
rrl	1476281	n.2624T>C	non_coding_transcript_exon_variant	0.82	capreomycin	Uncertain significance
rrl	1476281	n.2624T>C	non_coding_transcript_exon_variant	0.82	linezolid	Uncertain significance
rrl	1476288	n.2635_2643delGCACCCCCG	non_coding_transcript_exon_variant	0.82	capreomycin
rrl	1476288	n.2635_2643delGCACCCCCG	non_coding_transcript_exon_variant	0.82	linezolid
rrl	1476299	n.2642C>T	non_coding_transcript_exon_variant	0.8	capreomycin	Uncertain significance
rrl	1476299	n.2642C>T	non_coding_transcript_exon_variant	0.8	linezolid	Uncertain significance
rrl	1476301	n.2644_2645insCGGTGGCTT	non_coding_transcript_exon_variant	0.8	capreomycin
rrl	1476301	n.2644_2645insCGGTGGCTT	non_coding_transcript_exon_variant	0.8	linezolid
rrl	1476307	n.2650A>T	non_coding_transcript_exon_variant	0.79	capreomycin
rrl	1476307	n.2650A>T	non_coding_transcript_exon_variant	0.79	linezolid
rrl	1476309	n.2652G>C	non_coding_transcript_exon_variant	0.81	capreomycin	Uncertain significance
rrl	1476309	n.2652G>C	non_coding_transcript_exon_variant	0.81	linezolid	Uncertain significance
rrl	1476311	n.2654G>C	non_coding_transcript_exon_variant	0.8	capreomycin	Uncertain significance
rrl	1476311	n.2654G>C	non_coding_transcript_exon_variant	0.8	linezolid	Uncertain significance
rrl	1476312	n.2655T>C	non_coding_transcript_exon_variant	0.8	capreomycin	Uncertain significance
rrl	1476312	n.2655T>C	non_coding_transcript_exon_variant	0.8	linezolid	Uncertain significance
rrl	1476316	n.2659G>A	non_coding_transcript_exon_variant	0.82	capreomycin
rrl	1476316	n.2659G>A	non_coding_transcript_exon_variant	0.82	linezolid
rrl	1476359	n.2702C>G	non_coding_transcript_exon_variant	0.83	capreomycin	Uncertain significance
rrl	1476359	n.2702C>G	non_coding_transcript_exon_variant	0.83	linezolid	Uncertain significance
rrl	1476363	n.2706A>G	non_coding_transcript_exon_variant	0.82	capreomycin
rrl	1476363	n.2706A>G	non_coding_transcript_exon_variant	0.82	linezolid
rrl	1476366	n.2709A>C	non_coding_transcript_exon_variant	0.83	capreomycin
rrl	1476366	n.2709A>C	non_coding_transcript_exon_variant	0.83	linezolid
rrl	1476368	n.2711T>C	non_coding_transcript_exon_variant	0.82	capreomycin	Uncertain significance
rrl	1476368	n.2711T>C	non_coding_transcript_exon_variant	0.82	linezolid
rrl	1476369	n.2712C>T	non_coding_transcript_exon_variant	0.82	capreomycin	Uncertain significance
rrl	1476369	n.2712C>T	non_coding_transcript_exon_variant	0.82	linezolid	Uncertain significance
rrl	1476374	n.2717T>G	non_coding_transcript_exon_variant	0.82	capreomycin
rrl	1476374	n.2717T>G	non_coding_transcript_exon_variant	0.82	linezolid
rrl	1476381	n.2724G>C	non_coding_transcript_exon_variant	0.82	capreomycin	Uncertain significance
rrl	1476381	n.2724G>C	non_coding_transcript_exon_variant	0.82	linezolid	Uncertain significance
rrl	1476428	n.2771C>T	non_coding_transcript_exon_variant	0.74	capreomycin	Not assoc w R
rrl	1476428	n.2771C>T	non_coding_transcript_exon_variant	0.74	linezolid	Uncertain significance
rrl	1476429	n.2772A>C	non_coding_transcript_exon_variant	0.74	capreomycin	Uncertain significance
rrl	1476429	n.2772A>C	non_coding_transcript_exon_variant	0.74	linezolid	Uncertain significance
rrl	1476481	n.2824T>C	non_coding_transcript_exon_variant	0.58	capreomycin	Not assoc w R
rrl	1476481	n.2824T>C	non_coding_transcript_exon_variant	0.58	linezolid	Uncertain significance
rrl	1476506	n.2849T>C	non_coding_transcript_exon_variant	0.39	capreomycin	Not assoc w R
rrl	1476506	n.2849T>C	non_coding_transcript_exon_variant	0.39	linezolid	Uncertain significance
rpsA	1834345	c.804C>T	synonymous_variant	0.15	pyrazinamide
tlyA	1917972	c.33A>G	synonymous_variant	1.0	capreomycin	Not assoc w R
tlyA	1918631	p.Pro231Arg	missense_variant	1.0	capreomycin
PPE35	2168149	p.Pro822Ser	missense_variant	1.0	pyrazinamide	Not assoc w R
Rv1979c	2223293	c.-129A>G	upstream_gene_variant	1.0	clofazimine	Not assoc w R
Rv1979c	2223293	c.-129A>G	upstream_gene_variant	1.0	bedaquiline	Not assoc w R - Interim
Rv2680	2995848	c.-257G>A	upstream_gene_variant	1.0	capreomycin
Rv3236c	3613636	c.-520A>G	upstream_gene_variant	1.0	pyrazinamide	Not assoc w R
mtrA	3627020	c.330G>A	synonymous_variant	1.0	bedaquiline	Not assoc w R - Interim
mtrA	3627020	c.330G>A	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
clpC1	4039729	p.Asp326Asn	missense_variant	1.0	pyrazinamide	Not assoc w R
embC	4242643	c.2781C>T	synonymous_variant	1.0	ethambutol	Not assoc w R
whiB6	4338595	c.-75delG	upstream_gene_variant	1.0	capreomycin	Not assoc w R
					amikacin	Not assoc w R
					kanamycin	Not assoc w R

Drug	Resistance	Supporting mutations	WHO confidence	Comment
rifampicin
isoniazid
ethambutol
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin	rrs	n.1402C>A	Uncertain significance	Mutation from literature
amikacin	rrs	n.1484G>T	Assoc w R
capreomycin	rrs	n.1402C>A	Uncertain significance	Mutation from literature
capreomycin	rrs	n.1484G>T	Assoc w R
kanamycin	rrs	n.1402C>A	Uncertain significance	Mutation from literature
kanamycin	rrs	n.1484G>T	Assoc w R
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid

TB-Profiler result