TB-Profiler result

Run: SRR1181020
Summary

Run ID: SRR1181020

Sample name:

Date: 2024-04-16T10:36:17.976867

Number of reads: 677996

Percentage reads mapped: 64.4

Median coverage: 15.0

Strain: lineage2.2.1

Spoligotype:

Drug-resistance: Other

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage2 East-Asian RD105 1.0
lineage2.2.1 East-Asian (Beijing) RD105;RD207;RD181 0.92
lineage2.2 East-Asian (Beijing) RD105;RD207 0.99
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol
pyrazinamide
streptomycin rrs n.462C>T Uncertain significance Mutation from literature
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
rrs 1472307 n.462C>T non_coding_transcript_exon_variant 0.44 streptomycin Uncertain significance Mutation from literature
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
gyrB 6196 c.957C>T synonymous_variant 0.35 levofloxacin
moxifloxacin
gyrA 6727 c.-575G>T upstream_gene_variant 0.37 levofloxacin
moxifloxacin
gyrB 6728 c.1489_1491delCTAinsTG frameshift_variant&stop_gained 0.35 levofloxacin Uncertain significance
moxifloxacin
gyrA 6760 c.-542G>C upstream_gene_variant 0.38 levofloxacin
moxifloxacin
gyrB 6775 c.1536G>C synonymous_variant 0.33 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6793 c.1554T>C synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6798 p.Gly520Ala missense_variant 0.24 levofloxacin Not assoc w R
moxifloxacin Uncertain significance
gyrB 6808 c.1569C>T synonymous_variant 0.27 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 8324 c.1023T>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8327 c.1026C>G synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 8330 c.1029C>G synonymous_variant 0.27 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8339 c.1038A>C synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 8340 p.Ala347Ser missense_variant 0.27 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8372 c.1071G>C synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 8375 c.1074G>C synonymous_variant 0.29 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 8382 p.Leu361Met missense_variant 0.33 levofloxacin
moxifloxacin
gyrA 8453 c.1152A>C synonymous_variant 0.37 levofloxacin
moxifloxacin
gyrA 8462 c.1161A>G synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 8465 c.1164C>G synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 8471 c.1170T>C synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 8472 c.1171C>T synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 8480 c.1179C>T synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 8486 c.1185T>C synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8489 c.1188A>G synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 8504 c.1203G>C synonymous_variant 0.38 levofloxacin
moxifloxacin
gyrA 8516 c.1215T>C synonymous_variant 0.46 levofloxacin
moxifloxacin
gyrA 8519 c.1218A>C synonymous_variant 0.44 levofloxacin
moxifloxacin
gyrA 8528 c.1227G>C synonymous_variant 0.38 levofloxacin
moxifloxacin
gyrA 8546 p.Asp415Glu missense_variant 0.32 levofloxacin
moxifloxacin
gyrA 8552 c.1251C>G synonymous_variant 0.39 levofloxacin
moxifloxacin
gyrA 8561 c.1260A>C synonymous_variant 0.38 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8603 c.1302A>G synonymous_variant 0.41 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8619 c.1318T>C synonymous_variant 0.41 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8624 c.1323G>C synonymous_variant 0.43 levofloxacin
moxifloxacin
gyrA 8627 c.1326C>G synonymous_variant 0.47 levofloxacin
moxifloxacin
gyrA 8636 c.1335A>C synonymous_variant 0.5 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8642 c.1341A>G synonymous_variant 0.5 levofloxacin
moxifloxacin
gyrA 8903 c.1602T>C synonymous_variant 0.42 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8915 c.1614A>G synonymous_variant 0.42 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8933 c.1632G>C synonymous_variant 0.45 levofloxacin
moxifloxacin
gyrA 8939 c.1638T>C synonymous_variant 0.45 levofloxacin
moxifloxacin
gyrA 8942 c.1641G>C synonymous_variant 0.48 levofloxacin
moxifloxacin
gyrA 8966 c.1665C>G synonymous_variant 0.52 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8967 p.Ala556Arg missense_variant 0.52 levofloxacin
moxifloxacin
gyrA 8990 c.1689C>G synonymous_variant 0.46 levofloxacin
moxifloxacin
gyrA 8998 p.Leu566Trp missense_variant 0.39 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9002 c.1701C>T synonymous_variant 0.37 levofloxacin
moxifloxacin
gyrA 9017 c.1716C>G synonymous_variant 0.41 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9023 c.1722A>C synonymous_variant 0.45 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9029 c.1728T>G synonymous_variant 0.45 levofloxacin
moxifloxacin
gyrA 9051 c.1750T>C synonymous_variant 0.34 levofloxacin
moxifloxacin
gyrA 9248 c.1947G>C synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrA 9267 p.Asn656Gly missense_variant 0.37 levofloxacin
moxifloxacin
gyrA 9291 c.1990C>T synonymous_variant 0.36 levofloxacin
moxifloxacin
gyrA 9296 c.1995T>C synonymous_variant 0.35 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9299 c.1998G>C synonymous_variant 0.33 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9304 p.Gly668Glu missense_variant 1.0 levofloxacin
moxifloxacin
gyrA 9335 c.2034G>C synonymous_variant 0.35 levofloxacin
moxifloxacin
fgd1 491742 c.960T>C synonymous_variant 1.0 clofazimine Not assoc w R
pretomanid
delamanid Not assoc w R - Interim
Rv0565c 657081 c.390G>A synonymous_variant 1.0 ethionamide Not assoc w R - Interim
Rv0565c 657142 p.Arg110His missense_variant 1.0 ethionamide Uncertain significance
hadA 732346 c.417T>C synonymous_variant 0.43 isoniazid
hadA 732378 c.450_452dupAGA disruptive_inframe_insertion 0.5 isoniazid
hadA 732389 p.Ser154Thr missense_variant 0.5 isoniazid
hadA 732396 p.Gly156Ala missense_variant 0.5 isoniazid
hadA 732398 p.Ala157Thr missense_variant 0.44 isoniazid
rpoB 760091 c.285G>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 760101 c.295T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 760112 c.306T>C synonymous_variant 0.48 rifampicin
rpoB 760118 c.312T>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoB 760130 p.Asp108Glu missense_variant 0.57 rifampicin Uncertain significance
rpoB 760139 c.333A>G synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoB 760142 c.336C>G synonymous_variant 0.54 rifampicin
rpoB 760181 c.375T>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 760184 c.378A>G synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 760196 c.390C>G synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoB 760223 c.417T>C synonymous_variant 0.4 rifampicin
rpoB 760235 c.429T>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 760274 c.468G>A synonymous_variant 0.48 rifampicin
rpoB 760283 c.477G>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 760328 c.522G>C synonymous_variant 0.48 rifampicin
rpoB 760331 c.525G>C synonymous_variant 0.45 rifampicin
rpoB 760337 c.531C>G synonymous_variant 0.43 rifampicin
rpoB 760340 c.534G>C synonymous_variant 0.43 rifampicin
rpoB 760361 c.555T>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 760403 c.597C>T synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 760424 c.618C>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 760430 c.624T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 760460 c.654G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 760475 c.669A>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 760481 c.675G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 760484 c.678A>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 760511 c.705G>C synonymous_variant 0.41 rifampicin
rpoB 760520 c.714C>G synonymous_variant 0.32 rifampicin
rpoB 760522 p.Ser239Asn missense_variant 0.33 rifampicin Uncertain significance
rpoB 760532 c.726T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 760533 p.Val243Thr missense_variant 0.33 rifampicin
rpoB 760547 c.741G>T synonymous_variant 0.42 rifampicin
rpoB 760591 p.Val262Ala missense_variant 0.5 rifampicin
rpoB 760598 c.792C>T synonymous_variant 0.5 rifampicin
rpoB 760611 c.805T>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 760646 c.840C>G synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoB 760655 c.849A>G synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoB 760661 c.855A>G synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoB 760670 c.864G>C synonymous_variant 0.41 rifampicin
rpoB 760674 c.868T>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 760679 c.873A>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 760683 c.877T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 760765 p.Glu320Ala missense_variant 0.44 rifampicin
rpoB 760769 c.963C>G synonymous_variant 0.41 rifampicin
rpoB 760793 c.987A>G synonymous_variant 0.27 rifampicin
rpoB 760805 c.999G>C synonymous_variant 0.25 rifampicin
rpoB 760830 c.1024T>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 760886 c.1080A>G synonymous_variant 0.36 rifampicin
rpoB 760919 c.1113C>G synonymous_variant 0.4 rifampicin
rpoB 760925 c.1119T>C synonymous_variant 0.35 rifampicin
rpoB 760928 c.1122G>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 760931 c.1125C>G synonymous_variant 0.38 rifampicin
rpoB 760946 c.1140A>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 761180 c.1374A>C synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoB 761189 c.1383T>C synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoB 761195 c.1389G>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 761207 c.1401C>T synonymous_variant 0.53 rifampicin
rpoB 761234 c.1428G>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoB 761249 c.1443A>G synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoB 761255 c.1449T>G synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoB 761972 c.2166C>G synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 761999 c.2193G>C synonymous_variant 0.33 rifampicin
rpoB 762008 c.2202C>G synonymous_variant 0.4 rifampicin
rpoB 762014 c.2208C>T synonymous_variant 0.4 rifampicin
rpoB 762017 c.2211A>G synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 762053 c.2247T>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 762062 c.2256T>C synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>C synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoB 762074 c.2268C>G synonymous_variant 0.59 rifampicin
rpoB 762083 c.2277T>C synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoB 762086 c.2280G>C synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoB 762101 c.2295C>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 762114 p.Ile770Val missense_variant 0.39 rifampicin Uncertain significance
rpoB 762131 c.2325C>G synonymous_variant 0.28 rifampicin
rpoB 762233 c.2427G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 762254 c.2448T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 762257 c.2451C>G synonymous_variant 0.38 rifampicin
rpoB 762284 c.2478G>T synonymous_variant 0.5 rifampicin
rpoB 762293 c.2487T>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoB 762296 c.2490G>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoB 762317 c.2511A>G synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 762329 c.2523G>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 762338 c.2532T>C synonymous_variant 0.47 rifampicin
rpoB 762347 c.2541T>C synonymous_variant 0.48 rifampicin
rpoB 762362 p.Glu852Asp missense_variant 0.48 rifampicin
rpoB 762369 c.2563T>C synonymous_variant 0.42 rifampicin
rpoB 762489 p.Val895Gln missense_variant 0.27 rifampicin
rpoC 762509 c.-861T>G upstream_gene_variant 0.35 rifampicin
rpoB 762510 c.2704_2706delGCCinsCG frameshift_variant&missense_variant 0.35 rifampicin
rpoC 762533 c.-837T>C upstream_gene_variant 0.29 rifampicin
rpoC 762536 c.-834T>C upstream_gene_variant 0.27 rifampicin
rpoC 762537 c.-833T>C upstream_gene_variant 0.29 rifampicin
rpoB 762857 c.3051C>G synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoB 762860 c.3054G>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 762863 c.-507T>G upstream_gene_variant 0.5 rifampicin
rpoB 762899 c.3093G>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoB 762962 c.3156C>T synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoB 763028 c.3222T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>C synonymous_variant 0.69 rifampicin Not assoc w R
rpoB 763031 c.3225T>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 763034 c.3228C>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 763040 c.3234C>G synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 763070 c.3264T>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 763085 c.3279C>G synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 763115 c.3309T>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 763148 c.-222G>C upstream_gene_variant 0.36 rifampicin
rpoC 763158 c.-212C>T upstream_gene_variant 0.33 rifampicin
rpoB 763166 c.3360A>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 763202 c.-168A>C upstream_gene_variant 0.4 rifampicin
rpoC 763205 c.-165G>C upstream_gene_variant 0.38 rifampicin
rpoC 763206 c.-164_-162delAGTinsTCG upstream_gene_variant 0.38 rifampicin
rpoC 763402 c.33C>T synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 763408 c.39T>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 763411 c.42T>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 763414 c.45T>C synonymous_variant 0.38 rifampicin
rpoC 763441 c.72C>T synonymous_variant 0.52 rifampicin
rpoC 763444 c.75T>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 763456 c.87A>G synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoC 763486 c.117T>G synonymous_variant 0.57 rifampicin
rpoC 763501 c.132C>T synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoC 763528 c.159G>A synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 763573 c.204G>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 763576 c.207C>G synonymous_variant 0.37 rifampicin
rpoC 763594 c.225C>T synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 763603 c.234C>T synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 763636 c.267T>C synonymous_variant 0.29 rifampicin
rpoC 764338 c.969G>A synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 764497 c.1128A>G synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 764500 c.1131C>G synonymous_variant 0.41 rifampicin
rpoC 764521 c.1152T>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 764527 c.1158C>T synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 764536 c.1167G>C synonymous_variant 0.44 rifampicin
rpoC 764539 c.1170C>G synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 764548 c.1179G>A synonymous_variant 0.5 rifampicin
rpoC 764554 c.1185C>T synonymous_variant 0.45 rifampicin
rpoC 764575 c.1206T>C synonymous_variant 0.45 rifampicin
rpoC 764581 c.1212T>C synonymous_variant 0.48 rifampicin
rpoC 764593 c.1224C>T synonymous_variant 0.5 rifampicin
rpoC 764611 c.1242G>C synonymous_variant 0.52 rifampicin
rpoC 764626 c.1257C>T synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>T synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoC 764668 c.1299C>T synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoC 764764 c.1395T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 764803 c.1434C>T synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 764809 c.1440C>T synonymous_variant 0.44 rifampicin Not assoc w R
rpoC 764815 c.1446A>G synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 764827 c.1458G>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 764858 c.1489T>C synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoC 764888 c.1519T>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 764932 c.1563C>G synonymous_variant 0.47 rifampicin
rpoC 764948 c.1579T>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 764968 c.1599T>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 765469 c.2100G>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 765478 c.2109T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 765499 c.2130C>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 765508 c.2139C>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 765529 c.2160C>T synonymous_variant 0.38 rifampicin
rpoC 765541 c.2172C>G synonymous_variant 0.43 rifampicin
rpoC 765553 c.2184C>T synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 765556 c.2187G>C synonymous_variant 0.39 rifampicin
rpoC 765700 c.2331T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 765734 c.2365T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 765739 c.2370G>T synonymous_variant 0.33 rifampicin
rpoC 765772 c.2403C>G synonymous_variant 0.45 rifampicin
rpoC 765778 c.2409C>G synonymous_variant 0.45 rifampicin
rpoC 765784 c.2415C>G synonymous_variant 0.5 rifampicin
rpoC 765793 c.2424C>G synonymous_variant 0.52 rifampicin
rpoC 765796 c.2427C>T synonymous_variant 0.52 rifampicin
rpoC 765811 c.2442T>G synonymous_variant 0.55 rifampicin
rpoC 765826 c.2457T>C synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoC 765886 c.2517C>G synonymous_variant 0.5 rifampicin
rpoC 766522 c.3153C>T synonymous_variant 0.32 rifampicin
rpoC 766672 c.3303T>C synonymous_variant 0.56 rifampicin
rpoC 766774 c.3405T>C synonymous_variant 0.37 rifampicin
rpoC 766801 c.3432C>T synonymous_variant 0.35 rifampicin
rpoC 766804 c.3435A>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 766843 c.3474T>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 766861 c.3492G>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 766864 c.3495G>C synonymous_variant 0.37 rifampicin
rpoC 767167 c.3798C>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 767180 p.Ala1271Gln missense_variant 0.53 rifampicin
rpoC 767191 c.3822C>G synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoC 767206 c.3837C>G synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoC 767209 c.3840T>C synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoC 767212 c.3843G>C synonymous_variant 0.58 rifampicin
rpoC 767221 c.3852C>G synonymous_variant 0.58 rifampicin Not assoc w R - Interim
mmpL5 776100 p.Thr794Ile missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
mmpL5 776182 p.Asp767Asn missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R
mmpS5 779615 c.-710C>G upstream_gene_variant 1.0 clofazimine
bedaquiline
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781808 c.249C>T synonymous_variant 0.32 streptomycin
rpsL 781814 c.255C>T synonymous_variant 0.29 streptomycin
rpsL 781817 c.258G>T synonymous_variant 0.3 streptomycin
rpsL 781898 c.339A>T synonymous_variant 0.3 streptomycin
rpsL 781916 c.357T>C synonymous_variant 0.33 streptomycin
rplC 800567 c.-242A>G upstream_gene_variant 0.42 linezolid
rplC 800582 c.-227C>G upstream_gene_variant 0.5 linezolid
rplC 800591 c.-218C>T upstream_gene_variant 0.46 linezolid
rplC 800600 c.-209G>T upstream_gene_variant 0.5 linezolid
rplC 800612 c.-197A>G upstream_gene_variant 0.42 linezolid
rplC 800654 c.-155T>C upstream_gene_variant 0.35 linezolid
rplC 800693 c.-116A>G upstream_gene_variant 0.31 linezolid
rplC 800703 c.-106_-104delTTGinsCC upstream_gene_variant 0.27 linezolid
Rv1129c 1254562 c.-28T>C upstream_gene_variant 1.0 moxifloxacin Not assoc w R
levofloxacin Not assoc w R
rifampicin Not assoc w R
isoniazid Not assoc w R
fbiC 1303728 c.798G>C synonymous_variant 0.46 clofazimine
pretomanid
delamanid
fbiC 1303755 c.825T>C synonymous_variant 0.4 clofazimine
pretomanid
delamanid
fbiC 1304811 c.1881C>G synonymous_variant 0.5 clofazimine
pretomanid
delamanid
fbiC 1304817 c.1887T>C synonymous_variant 0.47 clofazimine
pretomanid
delamanid
Rv1258c 1406760 c.580_581insC frameshift_variant 1.0 streptomycin Uncertain significance
isoniazid Uncertain significance
pyrazinamide Uncertain significance
atpE 1461170 c.126A>G synonymous_variant 0.37 bedaquiline
atpE 1461185 c.141G>C synonymous_variant 0.35 bedaquiline
atpE 1461189 c.145C>T synonymous_variant 0.4 bedaquiline
atpE 1461194 c.150C>T synonymous_variant 0.42 bedaquiline
atpE 1461197 c.153A>G synonymous_variant 0.47 bedaquiline
atpE 1461219 c.175T>C synonymous_variant 0.5 bedaquiline
atpE 1461233 c.189A>C synonymous_variant 0.5 bedaquiline
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471923 n.78T>C non_coding_transcript_exon_variant 0.54 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471934 n.89A>G non_coding_transcript_exon_variant 0.57 streptomycin Uncertain significance
kanamycin
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.42 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472969 n.1124A>G non_coding_transcript_exon_variant 0.42 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472970 n.1125C>G non_coding_transcript_exon_variant 0.44 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472977 n.1132G>C non_coding_transcript_exon_variant 0.46 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472978 n.1133T>C non_coding_transcript_exon_variant 0.46 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473104 n.1259C>T non_coding_transcript_exon_variant 0.52 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473105 n.1260G>A non_coding_transcript_exon_variant 0.5 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473123 n.1278delAinsTT non_coding_transcript_exon_variant 0.59 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.55 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.42 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473288 n.1443C>T non_coding_transcript_exon_variant 0.44 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473290 n.1445C>T non_coding_transcript_exon_variant 0.44 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473291 n.1446G>T non_coding_transcript_exon_variant 0.46 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrl 1473756 n.99G>A non_coding_transcript_exon_variant 0.41 capreomycin
linezolid
rrl 1473758 n.101G>T non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid
rrl 1473839 n.182G>T non_coding_transcript_exon_variant 0.43 capreomycin
linezolid
rrl 1473877 n.220G>A non_coding_transcript_exon_variant 0.53 capreomycin
linezolid
rrl 1473898 n.241C>T non_coding_transcript_exon_variant 0.45 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473899 n.242A>C non_coding_transcript_exon_variant 0.45 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473936 n.279A>G non_coding_transcript_exon_variant 0.47 capreomycin
linezolid
rrl 1473943 n.286G>T non_coding_transcript_exon_variant 0.45 capreomycin Uncertain significance
linezolid
rrl 1473944 n.287G>A non_coding_transcript_exon_variant 0.45 capreomycin
linezolid
rrl 1474111 n.454T>C non_coding_transcript_exon_variant 0.59 capreomycin
linezolid
rrl 1474181 n.524C>T non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid
rrl 1474639 n.982G>A non_coding_transcript_exon_variant 0.54 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.42 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474823 n.1166C>T non_coding_transcript_exon_variant 0.46 capreomycin
linezolid
rrl 1474831 n.1174A>G non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid
rrl 1474956 n.1299C>T non_coding_transcript_exon_variant 0.42 capreomycin
linezolid
rrl 1474960 n.1303C>G non_coding_transcript_exon_variant 0.45 capreomycin
linezolid
rrl 1474963 n.1306G>T non_coding_transcript_exon_variant 0.43 capreomycin Uncertain significance
linezolid
rrl 1474964 n.1307T>A non_coding_transcript_exon_variant 0.45 capreomycin
linezolid
rrl 1474965 n.1308G>C non_coding_transcript_exon_variant 0.41 capreomycin
linezolid
rrl 1474970 n.1313G>A non_coding_transcript_exon_variant 0.43 capreomycin
linezolid
rrl 1475088 n.1431A>T non_coding_transcript_exon_variant 0.43 capreomycin
linezolid
rrl 1475199 n.1542G>A non_coding_transcript_exon_variant 0.44 capreomycin
linezolid
rrl 1475201 n.1544G>A non_coding_transcript_exon_variant 0.44 capreomycin
linezolid
rrl 1475206 n.1549C>T non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid
rrl 1475209 n.1552G>C non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid
rrl 1475213 n.1556C>T non_coding_transcript_exon_variant 0.43 capreomycin Uncertain significance
linezolid
rrl 1475249 n.1592T>C non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475252 n.1595C>T non_coding_transcript_exon_variant 0.29 capreomycin
linezolid
rrl 1475266 n.1609T>C non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475267 n.1610G>A non_coding_transcript_exon_variant 0.28 capreomycin
linezolid
rrl 1475275 n.1618C>T non_coding_transcript_exon_variant 0.28 capreomycin
linezolid
rrl 1475276 n.1619T>C non_coding_transcript_exon_variant 0.29 capreomycin
linezolid
rrl 1475291 n.1634A>C non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475315 n.1658A>T non_coding_transcript_exon_variant 0.48 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475355 n.1698C>T non_coding_transcript_exon_variant 0.69 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475369 n.1712G>C non_coding_transcript_exon_variant 0.66 capreomycin
linezolid
rrl 1475402 n.1745C>T non_coding_transcript_exon_variant 0.57 capreomycin
linezolid
rrl 1475409 n.1752T>C non_coding_transcript_exon_variant 0.54 capreomycin
linezolid
rrl 1475419 n.1762C>T non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid
rrl 1475429 n.1772G>A non_coding_transcript_exon_variant 0.47 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475483 n.1826C>T non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475505 n.1848G>A non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475599 n.1942A>G non_coding_transcript_exon_variant 0.44 capreomycin
linezolid Uncertain significance
rrl 1475608 n.1951T>C non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid
rrl 1475638 n.1981C>T non_coding_transcript_exon_variant 0.46 capreomycin
linezolid
rrl 1475642 n.1985T>C non_coding_transcript_exon_variant 0.42 capreomycin
linezolid
rrl 1475761 n.2104_2106delCGCinsGT non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1475765 n.2111delG non_coding_transcript_exon_variant 0.36 capreomycin
linezolid
rrl 1475881 n.2224T>C non_coding_transcript_exon_variant 0.63 capreomycin
linezolid
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.46 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476025 n.2368G>T non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1476045 n.2388G>T non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid
rrl 1476047 n.2390G>T non_coding_transcript_exon_variant 0.32 capreomycin
linezolid
rrl 1476048 n.2391G>A non_coding_transcript_exon_variant 0.32 capreomycin
linezolid
rrl 1476049 n.2392C>T non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476115 n.2458T>C non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476117 n.2460G>C non_coding_transcript_exon_variant 0.29 capreomycin
linezolid
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476297 n.2640C>T non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476299 n.2642C>T non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476583 n.2926G>A non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.41 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476597 n.2940G>A non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid
rrl 1476608 n.2951C>G non_coding_transcript_exon_variant 0.48 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.48 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476689 n.3032A>T non_coding_transcript_exon_variant 0.47 capreomycin
linezolid
rrl 1476690 n.3033C>T non_coding_transcript_exon_variant 0.47 capreomycin Uncertain significance
linezolid
rrl 1476693 n.3036G>A non_coding_transcript_exon_variant 0.47 capreomycin
linezolid
rrl 1476695 n.3038T>A non_coding_transcript_exon_variant 0.47 capreomycin
linezolid
inhA 1674690 c.489C>G synonymous_variant 0.38 ethionamide
isoniazid
inhA 1674703 c.502T>C synonymous_variant 0.35 ethionamide
isoniazid
inhA 1674708 c.507G>A synonymous_variant 0.32 ethionamide
isoniazid
inhA 1674714 c.513C>G synonymous_variant 0.35 ethionamide
isoniazid
rpsA 1833703 c.162C>T synonymous_variant 0.61 pyrazinamide Not assoc w R - Interim
rpsA 1833724 c.183C>G synonymous_variant 0.67 pyrazinamide
rpsA 1833727 c.186G>C synonymous_variant 0.65 pyrazinamide
rpsA 1833742 c.201A>G synonymous_variant 0.73 pyrazinamide
rpsA 1833745 c.204G>C synonymous_variant 0.73 pyrazinamide
rpsA 1833760 c.219C>T synonymous_variant 0.6 pyrazinamide Not assoc w R - Interim
rpsA 1833793 c.252C>T synonymous_variant 0.59 pyrazinamide
rpsA 1833811 c.270G>C synonymous_variant 0.62 pyrazinamide
rpsA 1833835 c.294C>T synonymous_variant 0.62 pyrazinamide
rpsA 1833838 c.297G>C synonymous_variant 0.58 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.56 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.59 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.64 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.4 pyrazinamide
rpsA 1833971 c.430C>T synonymous_variant 0.33 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.27 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.31 pyrazinamide
rpsA 1834021 c.480C>T synonymous_variant 0.44 pyrazinamide
rpsA 1834030 c.489C>G synonymous_variant 0.41 pyrazinamide
rpsA 1834097 c.556_557delTCinsAG synonymous_variant 0.44 pyrazinamide
rpsA 1834102 c.561T>G synonymous_variant 0.38 pyrazinamide
rpsA 1834177 c.636A>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
rpsA 1834222 c.681T>C synonymous_variant 0.39 pyrazinamide
rpsA 1834240 c.699T>C synonymous_variant 0.5 pyrazinamide
rpsA 1834249 c.708T>C synonymous_variant 0.52 pyrazinamide
rpsA 1834261 c.720A>G synonymous_variant 0.53 pyrazinamide Not assoc w R - Interim
rpsA 1834264 c.723G>C synonymous_variant 0.47 pyrazinamide
rpsA 1834294 c.753G>T synonymous_variant 0.5 pyrazinamide
rpsA 1834297 c.756C>T synonymous_variant 0.5 pyrazinamide
rpsA 1834303 c.762T>C synonymous_variant 0.44 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.46 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 0.39 pyrazinamide Not assoc w R - Interim
rpsA 1834396 c.855G>C synonymous_variant 0.44 pyrazinamide
rpsA 1834546 c.1005T>C synonymous_variant 0.47 pyrazinamide
rpsA 1834633 c.1092A>G synonymous_variant 0.34 pyrazinamide
rpsA 1834639 c.1098T>C synonymous_variant 0.31 pyrazinamide
rpsA 1834738 c.1197A>G synonymous_variant 0.4 pyrazinamide
rpsA 1834765 p.Glu408Asp missense_variant 0.47 pyrazinamide
PPE35 2167926 p.Leu896Ser missense_variant 1.0 pyrazinamide Not assoc w R
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
kasA 2518636 c.522C>T synonymous_variant 0.36 isoniazid
kasA 2518642 c.528A>G synonymous_variant 0.3 isoniazid
kasA 2518672 c.558G>C synonymous_variant 0.3 isoniazid
kasA 2518678 c.564C>T synonymous_variant 0.28 isoniazid
ahpC 2726633 c.441C>G synonymous_variant 0.5 isoniazid
ahpC 2726638 p.Ala149Val missense_variant 0.55 isoniazid
ahpC 2726645 c.453C>G synonymous_variant 0.5 isoniazid
ahpC 2726651 c.459G>C synonymous_variant 0.46 isoniazid
ahpC 2726657 c.465A>C synonymous_variant 0.4 isoniazid Not assoc w R - Interim
ahpC 2726669 p.Asp159Glu missense_variant 0.35 isoniazid
ahpC 2726675 c.483A>G synonymous_variant 0.33 isoniazid
ahpC 2726681 c.489A>C synonymous_variant 0.32 isoniazid Not assoc w R - Interim
Rv2477c 2782510 c.1533G>C synonymous_variant 0.45 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782528 c.1515G>C synonymous_variant 0.47 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782957 c.1086A>G synonymous_variant 0.41 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2782969 c.1074A>C synonymous_variant 0.38 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782981 c.1062G>C synonymous_variant 0.27 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782984 c.1059T>C synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783002 c.1041T>C synonymous_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783008 c.1035C>G synonymous_variant 0.3 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783013 c.1030T>C synonymous_variant 0.32 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783015 p.Ser343Thr missense_variant 0.31 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783020 c.1023G>C synonymous_variant 0.31 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783040 p.Ala335Thr missense_variant 0.39 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
kanamycin Uncertain significance
rifampicin Uncertain significance
amikacin Uncertain significance
Rv2477c 2783044 c.999G>C synonymous_variant 0.38 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783051 p.Tyr331Phe missense_variant 0.32 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783059 c.984T>C synonymous_variant 0.33 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783065 c.978C>T synonymous_variant 0.35 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783068 p.Asp325Glu missense_variant 0.35 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783077 c.966T>C synonymous_variant 0.42 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783086 c.957C>T synonymous_variant 0.44 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783092 c.951A>G synonymous_variant 0.43 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783095 c.948C>G synonymous_variant 0.44 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R
amikacin Not assoc w R - Interim
Rv2477c 2783116 c.927T>C synonymous_variant 0.46 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783140 c.903C>G synonymous_variant 0.42 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783149 c.894G>C synonymous_variant 0.54 ethambutol
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783158 c.885A>C synonymous_variant 0.5 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783182 c.861C>G synonymous_variant 0.41 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783193 p.Ser284Gly missense_variant 0.36 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783194 c.849A>G synonymous_variant 0.36 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783203 c.840C>T synonymous_variant 0.4 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783305 c.738G>A synonymous_variant 0.35 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783311 c.732T>C synonymous_variant 0.35 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783332 c.711T>C synonymous_variant 0.33 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783335 c.708C>G synonymous_variant 0.3 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
Rv3236c 3612813 p.Thr102Ala missense_variant 1.0 pyrazinamide Not assoc w R - Interim
mtrB 3626562 p.Pro18Ser missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
mtrB 3627104 c.-491C>G upstream_gene_variant 0.32 bedaquiline
rifampicin
mtrA 3627119 c.231T>G synonymous_variant 0.33 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627122 c.-509T>C upstream_gene_variant 0.36 bedaquiline
rifampicin
mtrB 3627128 c.-515T>C upstream_gene_variant 0.35 bedaquiline
rifampicin
mtrB 3627167 c.-554T>C upstream_gene_variant 0.48 bedaquiline
rifampicin
mtrB 3627181 c.-568T>C upstream_gene_variant 0.47 bedaquiline
rifampicin
mtrB 3627182 c.-569T>C upstream_gene_variant 0.47 bedaquiline
rifampicin
mtrA 3627187 c.163T>C synonymous_variant 0.5 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3627188 c.162A>G synonymous_variant 0.5 bedaquiline
rifampicin Not assoc w R - Interim
rpoA 3877656 c.852T>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoA 3877668 c.840A>G synonymous_variant 0.5 rifampicin
rpoA 3877677 p.Ala277Ser missense_variant 0.5 rifampicin
rpoA 3877704 c.804G>C synonymous_variant 0.44 rifampicin
rpoA 3877737 c.771G>C synonymous_variant 0.35 rifampicin
rpoA 3877770 c.738A>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoA 3877776 c.732T>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoA 3877782 c.726T>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoA 3878436 c.72A>G synonymous_variant 0.35 rifampicin
rpoA 3878442 c.66G>C synonymous_variant 0.38 rifampicin
rpoA 3878809 c.-302T>C upstream_gene_variant 0.32 rifampicin
rpoA 3878833 c.-326C>G upstream_gene_variant 0.33 rifampicin
rpoA 3878845 c.-338G>T upstream_gene_variant 0.36 rifampicin
rpoA 3878853 c.-346G>A upstream_gene_variant 0.36 rifampicin
rpoA 3878862 c.-355T>C upstream_gene_variant 0.3 rifampicin
rpoA 3878878 c.-371T>C upstream_gene_variant 0.32 rifampicin Uncertain significance
clpC1 4038359 c.2346A>G synonymous_variant 0.4 pyrazinamide
clpC1 4038368 c.2337T>C synonymous_variant 0.38 pyrazinamide
clpC1 4038388 c.2317T>C synonymous_variant 0.32 pyrazinamide
clpC1 4038392 c.2313C>T synonymous_variant 0.32 pyrazinamide
clpC1 4038671 c.2034T>C synonymous_variant 0.44 pyrazinamide
clpC1 4038683 c.2022T>C synonymous_variant 0.39 pyrazinamide Not assoc w R - Interim
clpC1 4038740 c.1965G>C synonymous_variant 0.35 pyrazinamide
clpC1 4038755 c.1950G>T synonymous_variant 0.3 pyrazinamide
clpC1 4038773 c.1932T>C synonymous_variant 0.32 pyrazinamide
clpC1 4038790 c.1915C>T synonymous_variant 0.39 pyrazinamide Not assoc w R - Interim
clpC1 4038812 c.1893T>C synonymous_variant 0.42 pyrazinamide
clpC1 4038815 c.1890G>C synonymous_variant 0.42 pyrazinamide
clpC1 4039064 c.1641C>T synonymous_variant 0.38 pyrazinamide
clpC1 4039898 c.807C>G synonymous_variant 0.33 pyrazinamide
clpC1 4039904 c.801A>G synonymous_variant 0.38 pyrazinamide
clpC1 4039931 c.774T>C synonymous_variant 0.3 pyrazinamide
clpC1 4039946 c.759A>T synonymous_variant 0.33 pyrazinamide
clpC1 4039952 c.753T>C synonymous_variant 0.35 pyrazinamide
embA 4245182 c.1950T>C synonymous_variant 0.33 ethambutol
embA 4245186 p.Thr652Ala missense_variant 0.33 ethambutol
aftB 4267647 p.Asp397Gly missense_variant 0.91 ethambutol Not assoc w R
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Not assoc w R
gid 4407588 c.615A>G synonymous_variant 1.0 streptomycin Not assoc w R
gid 4407620 p.Tyr195His missense_variant 1.0 streptomycin Not assoc w R