Run ID: SRR1181020
Sample name:
Date: 2024-04-16T10:36:17.976867
Number of reads: 677996
Percentage reads mapped: 64.4
Median coverage: 15.0
Strain: lineage2.2.1
Spoligotype:
Drug-resistance: Other
Lineage | Family | RDs | Frequency |
---|---|---|---|
lineage2 | East-Asian | RD105 | 1.0 |
lineage2.2.1 | East-Asian (Beijing) | RD105;RD207;RD181 | 0.92 |
lineage2.2 | East-Asian (Beijing) | RD105;RD207 | 0.99 |
Drug | Resistance | Supporting mutations | WHO confidence | Comment |
---|---|---|---|---|
rifampicin | ||||
isoniazid | ||||
ethambutol | ||||
pyrazinamide | ||||
streptomycin | rrs | n.462C>T | Uncertain significance | Mutation from literature |
fluoroquinolones | ||||
moxifloxacin | ||||
ofloxacin | ||||
levofloxacin | ||||
ciprofloxacin | ||||
aminoglycosides | ||||
amikacin | ||||
capreomycin | ||||
kanamycin | ||||
cycloserine | ||||
ethionamide | ||||
clofazimine | ||||
para-aminosalicylic_acid | ||||
delamanid | ||||
bedaquiline | ||||
linezolid |
Gene | Chromosome position | Mutation | Type | Estimated fraction | Drugs | Confidence | Comment |
---|---|---|---|---|---|---|---|
rrs | 1472307 | n.462C>T | non_coding_transcript_exon_variant | 0.44 | streptomycin | Uncertain significance | Mutation from literature |
Gene | Chromosome position | Mutation | Type | Estimated fraction | Drugs | Confidence |
---|---|---|---|---|---|---|
gyrB | 6196 | c.957C>T | synonymous_variant | 0.35 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 6727 | c.-575G>T | upstream_gene_variant | 0.37 | levofloxacin | |
moxifloxacin | ||||||
gyrB | 6728 | c.1489_1491delCTAinsTG | frameshift_variant&stop_gained | 0.35 | levofloxacin | Uncertain significance |
moxifloxacin | ||||||
gyrA | 6760 | c.-542G>C | upstream_gene_variant | 0.38 | levofloxacin | |
moxifloxacin | ||||||
gyrB | 6775 | c.1536G>C | synonymous_variant | 0.33 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrB | 6793 | c.1554T>C | synonymous_variant | 0.26 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrB | 6798 | p.Gly520Ala | missense_variant | 0.24 | levofloxacin | Not assoc w R |
moxifloxacin | Uncertain significance | |||||
gyrB | 6808 | c.1569C>T | synonymous_variant | 0.27 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 7362 | p.Glu21Gln | missense_variant | 1.0 | levofloxacin | Not assoc w R |
moxifloxacin | Not assoc w R | |||||
gyrA | 7585 | p.Ser95Thr | missense_variant | 1.0 | levofloxacin | Not assoc w R |
moxifloxacin | Not assoc w R | |||||
gyrA | 8324 | c.1023T>C | synonymous_variant | 0.24 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8327 | c.1026C>G | synonymous_variant | 0.27 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8330 | c.1029C>G | synonymous_variant | 0.27 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 8339 | c.1038A>C | synonymous_variant | 0.29 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8340 | p.Ala347Ser | missense_variant | 0.27 | levofloxacin | Uncertain significance |
moxifloxacin | Uncertain significance | |||||
gyrA | 8372 | c.1071G>C | synonymous_variant | 0.29 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8375 | c.1074G>C | synonymous_variant | 0.29 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | ||||||
gyrA | 8382 | p.Leu361Met | missense_variant | 0.33 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8453 | c.1152A>C | synonymous_variant | 0.37 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8462 | c.1161A>G | synonymous_variant | 0.27 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8465 | c.1164C>G | synonymous_variant | 0.29 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8471 | c.1170T>C | synonymous_variant | 0.27 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8472 | c.1171C>T | synonymous_variant | 0.27 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8480 | c.1179C>T | synonymous_variant | 0.27 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8486 | c.1185T>C | synonymous_variant | 0.26 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 8489 | c.1188A>G | synonymous_variant | 0.26 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8504 | c.1203G>C | synonymous_variant | 0.38 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8516 | c.1215T>C | synonymous_variant | 0.46 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8519 | c.1218A>C | synonymous_variant | 0.44 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8528 | c.1227G>C | synonymous_variant | 0.38 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8546 | p.Asp415Glu | missense_variant | 0.32 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8552 | c.1251C>G | synonymous_variant | 0.39 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8561 | c.1260A>C | synonymous_variant | 0.38 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 8603 | c.1302A>G | synonymous_variant | 0.41 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 8619 | c.1318T>C | synonymous_variant | 0.41 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 8624 | c.1323G>C | synonymous_variant | 0.43 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8627 | c.1326C>G | synonymous_variant | 0.47 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8636 | c.1335A>C | synonymous_variant | 0.5 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 8642 | c.1341A>G | synonymous_variant | 0.5 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8903 | c.1602T>C | synonymous_variant | 0.42 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 8915 | c.1614A>G | synonymous_variant | 0.42 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 8933 | c.1632G>C | synonymous_variant | 0.45 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8939 | c.1638T>C | synonymous_variant | 0.45 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8942 | c.1641G>C | synonymous_variant | 0.48 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8966 | c.1665C>G | synonymous_variant | 0.52 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 8967 | p.Ala556Arg | missense_variant | 0.52 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8990 | c.1689C>G | synonymous_variant | 0.46 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8998 | p.Leu566Trp | missense_variant | 0.39 | levofloxacin | Uncertain significance |
moxifloxacin | Uncertain significance | |||||
gyrA | 9002 | c.1701C>T | synonymous_variant | 0.37 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 9017 | c.1716C>G | synonymous_variant | 0.41 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 9023 | c.1722A>C | synonymous_variant | 0.45 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 9029 | c.1728T>G | synonymous_variant | 0.45 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 9051 | c.1750T>C | synonymous_variant | 0.34 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 9248 | c.1947G>C | synonymous_variant | 0.33 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 9267 | p.Asn656Gly | missense_variant | 0.37 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 9291 | c.1990C>T | synonymous_variant | 0.36 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 9296 | c.1995T>C | synonymous_variant | 0.35 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 9299 | c.1998G>C | synonymous_variant | 0.33 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 9304 | p.Gly668Glu | missense_variant | 1.0 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 9335 | c.2034G>C | synonymous_variant | 0.35 | levofloxacin | |
moxifloxacin | ||||||
fgd1 | 491742 | c.960T>C | synonymous_variant | 1.0 | clofazimine | Not assoc w R |
pretomanid | ||||||
delamanid | Not assoc w R - Interim | |||||
Rv0565c | 657081 | c.390G>A | synonymous_variant | 1.0 | ethionamide | Not assoc w R - Interim |
Rv0565c | 657142 | p.Arg110His | missense_variant | 1.0 | ethionamide | Uncertain significance |
hadA | 732346 | c.417T>C | synonymous_variant | 0.43 | isoniazid | |
hadA | 732378 | c.450_452dupAGA | disruptive_inframe_insertion | 0.5 | isoniazid | |
hadA | 732389 | p.Ser154Thr | missense_variant | 0.5 | isoniazid | |
hadA | 732396 | p.Gly156Ala | missense_variant | 0.5 | isoniazid | |
hadA | 732398 | p.Ala157Thr | missense_variant | 0.44 | isoniazid | |
rpoB | 760091 | c.285G>C | synonymous_variant | 0.32 | rifampicin | Not assoc w R - Interim |
rpoB | 760101 | c.295T>C | synonymous_variant | 0.35 | rifampicin | Not assoc w R - Interim |
rpoB | 760112 | c.306T>C | synonymous_variant | 0.48 | rifampicin | |
rpoB | 760118 | c.312T>C | synonymous_variant | 0.52 | rifampicin | Not assoc w R - Interim |
rpoB | 760130 | p.Asp108Glu | missense_variant | 0.57 | rifampicin | Uncertain significance |
rpoB | 760139 | c.333A>G | synonymous_variant | 0.58 | rifampicin | Not assoc w R - Interim |
rpoB | 760142 | c.336C>G | synonymous_variant | 0.54 | rifampicin | |
rpoB | 760181 | c.375T>C | synonymous_variant | 0.39 | rifampicin | Not assoc w R - Interim |
rpoB | 760184 | c.378A>G | synonymous_variant | 0.4 | rifampicin | Not assoc w R - Interim |
rpoB | 760196 | c.390C>G | synonymous_variant | 0.45 | rifampicin | Not assoc w R - Interim |
rpoB | 760223 | c.417T>C | synonymous_variant | 0.4 | rifampicin | |
rpoB | 760235 | c.429T>C | synonymous_variant | 0.42 | rifampicin | Not assoc w R - Interim |
rpoB | 760274 | c.468G>A | synonymous_variant | 0.48 | rifampicin | |
rpoB | 760283 | c.477G>C | synonymous_variant | 0.48 | rifampicin | Not assoc w R - Interim |
rpoB | 760328 | c.522G>C | synonymous_variant | 0.48 | rifampicin | |
rpoB | 760331 | c.525G>C | synonymous_variant | 0.45 | rifampicin | |
rpoB | 760337 | c.531C>G | synonymous_variant | 0.43 | rifampicin | |
rpoB | 760340 | c.534G>C | synonymous_variant | 0.43 | rifampicin | |
rpoB | 760361 | c.555T>C | synonymous_variant | 0.37 | rifampicin | Not assoc w R - Interim |
rpoB | 760403 | c.597C>T | synonymous_variant | 0.3 | rifampicin | Not assoc w R - Interim |
rpoB | 760424 | c.618C>G | synonymous_variant | 0.28 | rifampicin | Not assoc w R - Interim |
rpoB | 760430 | c.624T>C | synonymous_variant | 0.27 | rifampicin | Not assoc w R - Interim |
rpoB | 760460 | c.654G>C | synonymous_variant | 0.29 | rifampicin | Not assoc w R - Interim |
rpoB | 760475 | c.669A>G | synonymous_variant | 0.32 | rifampicin | Not assoc w R - Interim |
rpoB | 760481 | c.675G>C | synonymous_variant | 0.33 | rifampicin | Not assoc w R - Interim |
rpoB | 760484 | c.678A>G | synonymous_variant | 0.38 | rifampicin | Not assoc w R - Interim |
rpoB | 760511 | c.705G>C | synonymous_variant | 0.41 | rifampicin | |
rpoB | 760520 | c.714C>G | synonymous_variant | 0.32 | rifampicin | |
rpoB | 760522 | p.Ser239Asn | missense_variant | 0.33 | rifampicin | Uncertain significance |
rpoB | 760532 | c.726T>C | synonymous_variant | 0.33 | rifampicin | Not assoc w R - Interim |
rpoB | 760533 | p.Val243Thr | missense_variant | 0.33 | rifampicin | |
rpoB | 760547 | c.741G>T | synonymous_variant | 0.42 | rifampicin | |
rpoB | 760591 | p.Val262Ala | missense_variant | 0.5 | rifampicin | |
rpoB | 760598 | c.792C>T | synonymous_variant | 0.5 | rifampicin | |
rpoB | 760611 | c.805T>C | synonymous_variant | 0.48 | rifampicin | Not assoc w R - Interim |
rpoB | 760646 | c.840C>G | synonymous_variant | 0.55 | rifampicin | Not assoc w R - Interim |
rpoB | 760655 | c.849A>G | synonymous_variant | 0.53 | rifampicin | Not assoc w R - Interim |
rpoB | 760661 | c.855A>G | synonymous_variant | 0.47 | rifampicin | Not assoc w R - Interim |
rpoB | 760670 | c.864G>C | synonymous_variant | 0.41 | rifampicin | |
rpoB | 760674 | c.868T>C | synonymous_variant | 0.39 | rifampicin | Not assoc w R - Interim |
rpoB | 760679 | c.873A>G | synonymous_variant | 0.38 | rifampicin | Not assoc w R - Interim |
rpoB | 760683 | c.877T>C | synonymous_variant | 0.31 | rifampicin | Not assoc w R - Interim |
rpoB | 760765 | p.Glu320Ala | missense_variant | 0.44 | rifampicin | |
rpoB | 760769 | c.963C>G | synonymous_variant | 0.41 | rifampicin | |
rpoB | 760793 | c.987A>G | synonymous_variant | 0.27 | rifampicin | |
rpoB | 760805 | c.999G>C | synonymous_variant | 0.25 | rifampicin | |
rpoB | 760830 | c.1024T>C | synonymous_variant | 0.36 | rifampicin | Not assoc w R - Interim |
rpoB | 760886 | c.1080A>G | synonymous_variant | 0.36 | rifampicin | |
rpoB | 760919 | c.1113C>G | synonymous_variant | 0.4 | rifampicin | |
rpoB | 760925 | c.1119T>C | synonymous_variant | 0.35 | rifampicin | |
rpoB | 760928 | c.1122G>C | synonymous_variant | 0.35 | rifampicin | Not assoc w R - Interim |
rpoB | 760931 | c.1125C>G | synonymous_variant | 0.38 | rifampicin | |
rpoB | 760946 | c.1140A>G | synonymous_variant | 0.36 | rifampicin | Not assoc w R - Interim |
rpoB | 761180 | c.1374A>C | synonymous_variant | 0.53 | rifampicin | Not assoc w R - Interim |
rpoB | 761189 | c.1383T>C | synonymous_variant | 0.56 | rifampicin | Not assoc w R - Interim |
rpoB | 761195 | c.1389G>C | synonymous_variant | 0.5 | rifampicin | Not assoc w R - Interim |
rpoB | 761207 | c.1401C>T | synonymous_variant | 0.53 | rifampicin | |
rpoB | 761234 | c.1428G>C | synonymous_variant | 0.45 | rifampicin | Not assoc w R - Interim |
rpoB | 761249 | c.1443A>G | synonymous_variant | 0.47 | rifampicin | Not assoc w R - Interim |
rpoB | 761255 | c.1449T>G | synonymous_variant | 0.47 | rifampicin | Not assoc w R - Interim |
rpoB | 761972 | c.2166C>G | synonymous_variant | 0.48 | rifampicin | Not assoc w R - Interim |
rpoB | 761999 | c.2193G>C | synonymous_variant | 0.33 | rifampicin | |
rpoB | 762008 | c.2202C>G | synonymous_variant | 0.4 | rifampicin | |
rpoB | 762014 | c.2208C>T | synonymous_variant | 0.4 | rifampicin | |
rpoB | 762017 | c.2211A>G | synonymous_variant | 0.4 | rifampicin | Not assoc w R - Interim |
rpoB | 762053 | c.2247T>C | synonymous_variant | 0.5 | rifampicin | Not assoc w R - Interim |
rpoB | 762062 | c.2256T>C | synonymous_variant | 0.57 | rifampicin | Not assoc w R - Interim |
rpoB | 762065 | c.2259T>C | synonymous_variant | 0.57 | rifampicin | Not assoc w R - Interim |
rpoB | 762074 | c.2268C>G | synonymous_variant | 0.59 | rifampicin | |
rpoB | 762083 | c.2277T>C | synonymous_variant | 0.56 | rifampicin | Not assoc w R - Interim |
rpoB | 762086 | c.2280G>C | synonymous_variant | 0.54 | rifampicin | Not assoc w R - Interim |
rpoB | 762101 | c.2295C>G | synonymous_variant | 0.5 | rifampicin | Not assoc w R - Interim |
rpoB | 762114 | p.Ile770Val | missense_variant | 0.39 | rifampicin | Uncertain significance |
rpoB | 762131 | c.2325C>G | synonymous_variant | 0.28 | rifampicin | |
rpoB | 762233 | c.2427G>C | synonymous_variant | 0.33 | rifampicin | Not assoc w R - Interim |
rpoB | 762254 | c.2448T>C | synonymous_variant | 0.35 | rifampicin | Not assoc w R - Interim |
rpoB | 762257 | c.2451C>G | synonymous_variant | 0.38 | rifampicin | |
rpoB | 762284 | c.2478G>T | synonymous_variant | 0.5 | rifampicin | |
rpoB | 762293 | c.2487T>C | synonymous_variant | 0.46 | rifampicin | Not assoc w R - Interim |
rpoB | 762296 | c.2490G>C | synonymous_variant | 0.45 | rifampicin | Not assoc w R - Interim |
rpoB | 762317 | c.2511A>G | synonymous_variant | 0.42 | rifampicin | Not assoc w R - Interim |
rpoB | 762329 | c.2523G>C | synonymous_variant | 0.43 | rifampicin | Not assoc w R - Interim |
rpoB | 762338 | c.2532T>C | synonymous_variant | 0.47 | rifampicin | |
rpoB | 762347 | c.2541T>C | synonymous_variant | 0.48 | rifampicin | |
rpoB | 762362 | p.Glu852Asp | missense_variant | 0.48 | rifampicin | |
rpoB | 762369 | c.2563T>C | synonymous_variant | 0.42 | rifampicin | |
rpoB | 762489 | p.Val895Gln | missense_variant | 0.27 | rifampicin | |
rpoC | 762509 | c.-861T>G | upstream_gene_variant | 0.35 | rifampicin | |
rpoB | 762510 | c.2704_2706delGCCinsCG | frameshift_variant&missense_variant | 0.35 | rifampicin | |
rpoC | 762533 | c.-837T>C | upstream_gene_variant | 0.29 | rifampicin | |
rpoC | 762536 | c.-834T>C | upstream_gene_variant | 0.27 | rifampicin | |
rpoC | 762537 | c.-833T>C | upstream_gene_variant | 0.29 | rifampicin | |
rpoB | 762857 | c.3051C>G | synonymous_variant | 0.45 | rifampicin | Not assoc w R - Interim |
rpoB | 762860 | c.3054G>C | synonymous_variant | 0.43 | rifampicin | Not assoc w R - Interim |
rpoC | 762863 | c.-507T>G | upstream_gene_variant | 0.5 | rifampicin | |
rpoB | 762899 | c.3093G>C | synonymous_variant | 0.55 | rifampicin | Not assoc w R - Interim |
rpoB | 762962 | c.3156C>T | synonymous_variant | 0.47 | rifampicin | Not assoc w R - Interim |
rpoB | 763028 | c.3222T>C | synonymous_variant | 0.31 | rifampicin | Not assoc w R - Interim |
rpoB | 763031 | c.3225T>C | synonymous_variant | 0.69 | rifampicin | Not assoc w R |
rpoB | 763031 | c.3225T>G | synonymous_variant | 0.31 | rifampicin | Not assoc w R - Interim |
rpoB | 763034 | c.3228C>G | synonymous_variant | 0.37 | rifampicin | Not assoc w R - Interim |
rpoB | 763040 | c.3234C>G | synonymous_variant | 0.42 | rifampicin | Not assoc w R - Interim |
rpoB | 763070 | c.3264T>C | synonymous_variant | 0.42 | rifampicin | Not assoc w R - Interim |
rpoB | 763085 | c.3279C>G | synonymous_variant | 0.4 | rifampicin | Not assoc w R - Interim |
rpoB | 763115 | c.3309T>C | synonymous_variant | 0.42 | rifampicin | Not assoc w R - Interim |
rpoC | 763148 | c.-222G>C | upstream_gene_variant | 0.36 | rifampicin | |
rpoC | 763158 | c.-212C>T | upstream_gene_variant | 0.33 | rifampicin | |
rpoB | 763166 | c.3360A>G | synonymous_variant | 0.38 | rifampicin | Not assoc w R - Interim |
rpoC | 763202 | c.-168A>C | upstream_gene_variant | 0.4 | rifampicin | |
rpoC | 763205 | c.-165G>C | upstream_gene_variant | 0.38 | rifampicin | |
rpoC | 763206 | c.-164_-162delAGTinsTCG | upstream_gene_variant | 0.38 | rifampicin | |
rpoC | 763402 | c.33C>T | synonymous_variant | 0.37 | rifampicin | Not assoc w R - Interim |
rpoC | 763408 | c.39T>C | synonymous_variant | 0.37 | rifampicin | Not assoc w R - Interim |
rpoC | 763411 | c.42T>G | synonymous_variant | 0.38 | rifampicin | Not assoc w R - Interim |
rpoC | 763414 | c.45T>C | synonymous_variant | 0.38 | rifampicin | |
rpoC | 763441 | c.72C>T | synonymous_variant | 0.52 | rifampicin | |
rpoC | 763444 | c.75T>C | synonymous_variant | 0.48 | rifampicin | Not assoc w R - Interim |
rpoC | 763456 | c.87A>G | synonymous_variant | 0.61 | rifampicin | Not assoc w R - Interim |
rpoC | 763486 | c.117T>G | synonymous_variant | 0.57 | rifampicin | |
rpoC | 763501 | c.132C>T | synonymous_variant | 0.58 | rifampicin | Not assoc w R - Interim |
rpoC | 763528 | c.159G>A | synonymous_variant | 0.55 | rifampicin | Not assoc w R - Interim |
rpoC | 763546 | c.177A>G | synonymous_variant | 0.54 | rifampicin | Not assoc w R - Interim |
rpoC | 763570 | c.201G>C | synonymous_variant | 0.44 | rifampicin | Not assoc w R - Interim |
rpoC | 763573 | c.204G>C | synonymous_variant | 0.41 | rifampicin | Not assoc w R - Interim |
rpoC | 763576 | c.207C>G | synonymous_variant | 0.37 | rifampicin | |
rpoC | 763594 | c.225C>T | synonymous_variant | 0.39 | rifampicin | Not assoc w R - Interim |
rpoC | 763603 | c.234C>T | synonymous_variant | 0.38 | rifampicin | Not assoc w R - Interim |
rpoC | 763636 | c.267T>C | synonymous_variant | 0.29 | rifampicin | |
rpoC | 764338 | c.969G>A | synonymous_variant | 0.42 | rifampicin | Not assoc w R - Interim |
rpoC | 764497 | c.1128A>G | synonymous_variant | 0.4 | rifampicin | Not assoc w R - Interim |
rpoC | 764500 | c.1131C>G | synonymous_variant | 0.41 | rifampicin | |
rpoC | 764521 | c.1152T>C | synonymous_variant | 0.43 | rifampicin | Not assoc w R - Interim |
rpoC | 764527 | c.1158C>T | synonymous_variant | 0.42 | rifampicin | Not assoc w R - Interim |
rpoC | 764536 | c.1167G>C | synonymous_variant | 0.44 | rifampicin | |
rpoC | 764539 | c.1170C>G | synonymous_variant | 0.44 | rifampicin | Not assoc w R - Interim |
rpoC | 764548 | c.1179G>A | synonymous_variant | 0.5 | rifampicin | |
rpoC | 764554 | c.1185C>T | synonymous_variant | 0.45 | rifampicin | |
rpoC | 764575 | c.1206T>C | synonymous_variant | 0.45 | rifampicin | |
rpoC | 764581 | c.1212T>C | synonymous_variant | 0.48 | rifampicin | |
rpoC | 764593 | c.1224C>T | synonymous_variant | 0.5 | rifampicin | |
rpoC | 764611 | c.1242G>C | synonymous_variant | 0.52 | rifampicin | |
rpoC | 764626 | c.1257C>T | synonymous_variant | 0.55 | rifampicin | Not assoc w R - Interim |
rpoC | 764650 | c.1281G>T | synonymous_variant | 0.67 | rifampicin | Not assoc w R - Interim |
rpoC | 764668 | c.1299C>T | synonymous_variant | 0.7 | rifampicin | Not assoc w R - Interim |
rpoC | 764764 | c.1395T>C | synonymous_variant | 0.29 | rifampicin | Not assoc w R - Interim |
rpoC | 764803 | c.1434C>T | synonymous_variant | 0.44 | rifampicin | Not assoc w R - Interim |
rpoC | 764809 | c.1440C>T | synonymous_variant | 0.44 | rifampicin | Not assoc w R |
rpoC | 764815 | c.1446A>G | synonymous_variant | 0.46 | rifampicin | Not assoc w R - Interim |
rpoC | 764827 | c.1458G>C | synonymous_variant | 0.48 | rifampicin | Not assoc w R - Interim |
rpoC | 764858 | c.1489T>C | synonymous_variant | 0.54 | rifampicin | Not assoc w R - Interim |
rpoC | 764888 | c.1519T>C | synonymous_variant | 0.45 | rifampicin | Not assoc w R - Interim |
rpoC | 764932 | c.1563C>G | synonymous_variant | 0.47 | rifampicin | |
rpoC | 764948 | c.1579T>C | synonymous_variant | 0.47 | rifampicin | Not assoc w R - Interim |
rpoC | 764968 | c.1599T>C | synonymous_variant | 0.5 | rifampicin | Not assoc w R - Interim |
rpoC | 765469 | c.2100G>C | synonymous_variant | 0.35 | rifampicin | Not assoc w R - Interim |
rpoC | 765478 | c.2109T>C | synonymous_variant | 0.35 | rifampicin | Not assoc w R - Interim |
rpoC | 765499 | c.2130C>G | synonymous_variant | 0.38 | rifampicin | Not assoc w R - Interim |
rpoC | 765508 | c.2139C>G | synonymous_variant | 0.38 | rifampicin | Not assoc w R - Interim |
rpoC | 765529 | c.2160C>T | synonymous_variant | 0.38 | rifampicin | |
rpoC | 765541 | c.2172C>G | synonymous_variant | 0.43 | rifampicin | |
rpoC | 765553 | c.2184C>T | synonymous_variant | 0.43 | rifampicin | Not assoc w R - Interim |
rpoC | 765556 | c.2187G>C | synonymous_variant | 0.39 | rifampicin | |
rpoC | 765700 | c.2331T>C | synonymous_variant | 0.35 | rifampicin | Not assoc w R - Interim |
rpoC | 765734 | c.2365T>C | synonymous_variant | 0.3 | rifampicin | Not assoc w R - Interim |
rpoC | 765739 | c.2370G>T | synonymous_variant | 0.33 | rifampicin | |
rpoC | 765772 | c.2403C>G | synonymous_variant | 0.45 | rifampicin | |
rpoC | 765778 | c.2409C>G | synonymous_variant | 0.45 | rifampicin | |
rpoC | 765784 | c.2415C>G | synonymous_variant | 0.5 | rifampicin | |
rpoC | 765793 | c.2424C>G | synonymous_variant | 0.52 | rifampicin | |
rpoC | 765796 | c.2427C>T | synonymous_variant | 0.52 | rifampicin | |
rpoC | 765811 | c.2442T>G | synonymous_variant | 0.55 | rifampicin | |
rpoC | 765826 | c.2457T>C | synonymous_variant | 0.63 | rifampicin | Not assoc w R - Interim |
rpoC | 765886 | c.2517C>G | synonymous_variant | 0.5 | rifampicin | |
rpoC | 766522 | c.3153C>T | synonymous_variant | 0.32 | rifampicin | |
rpoC | 766672 | c.3303T>C | synonymous_variant | 0.56 | rifampicin | |
rpoC | 766774 | c.3405T>C | synonymous_variant | 0.37 | rifampicin | |
rpoC | 766801 | c.3432C>T | synonymous_variant | 0.35 | rifampicin | |
rpoC | 766804 | c.3435A>G | synonymous_variant | 0.38 | rifampicin | Not assoc w R - Interim |
rpoC | 766843 | c.3474T>C | synonymous_variant | 0.47 | rifampicin | Not assoc w R - Interim |
rpoC | 766861 | c.3492G>C | synonymous_variant | 0.37 | rifampicin | Not assoc w R - Interim |
rpoC | 766864 | c.3495G>C | synonymous_variant | 0.37 | rifampicin | |
rpoC | 767167 | c.3798C>G | synonymous_variant | 0.5 | rifampicin | Not assoc w R - Interim |
rpoC | 767180 | p.Ala1271Gln | missense_variant | 0.53 | rifampicin | |
rpoC | 767191 | c.3822C>G | synonymous_variant | 0.57 | rifampicin | Not assoc w R - Interim |
rpoC | 767206 | c.3837C>G | synonymous_variant | 0.62 | rifampicin | Not assoc w R - Interim |
rpoC | 767209 | c.3840T>C | synonymous_variant | 0.58 | rifampicin | Not assoc w R - Interim |
rpoC | 767212 | c.3843G>C | synonymous_variant | 0.58 | rifampicin | |
rpoC | 767221 | c.3852C>G | synonymous_variant | 0.58 | rifampicin | Not assoc w R - Interim |
mmpL5 | 776100 | p.Thr794Ile | missense_variant | 1.0 | clofazimine | Not assoc w R |
bedaquiline | Not assoc w R - Interim | |||||
mmpL5 | 776182 | p.Asp767Asn | missense_variant | 1.0 | clofazimine | Not assoc w R |
bedaquiline | Not assoc w R | |||||
mmpS5 | 779615 | c.-710C>G | upstream_gene_variant | 1.0 | clofazimine | |
bedaquiline | ||||||
rpsL | 781395 | c.-165T>C | upstream_gene_variant | 1.0 | streptomycin | Not assoc w R |
rpsL | 781808 | c.249C>T | synonymous_variant | 0.32 | streptomycin | |
rpsL | 781814 | c.255C>T | synonymous_variant | 0.29 | streptomycin | |
rpsL | 781817 | c.258G>T | synonymous_variant | 0.3 | streptomycin | |
rpsL | 781898 | c.339A>T | synonymous_variant | 0.3 | streptomycin | |
rpsL | 781916 | c.357T>C | synonymous_variant | 0.33 | streptomycin | |
rplC | 800567 | c.-242A>G | upstream_gene_variant | 0.42 | linezolid | |
rplC | 800582 | c.-227C>G | upstream_gene_variant | 0.5 | linezolid | |
rplC | 800591 | c.-218C>T | upstream_gene_variant | 0.46 | linezolid | |
rplC | 800600 | c.-209G>T | upstream_gene_variant | 0.5 | linezolid | |
rplC | 800612 | c.-197A>G | upstream_gene_variant | 0.42 | linezolid | |
rplC | 800654 | c.-155T>C | upstream_gene_variant | 0.35 | linezolid | |
rplC | 800693 | c.-116A>G | upstream_gene_variant | 0.31 | linezolid | |
rplC | 800703 | c.-106_-104delTTGinsCC | upstream_gene_variant | 0.27 | linezolid | |
Rv1129c | 1254562 | c.-28T>C | upstream_gene_variant | 1.0 | moxifloxacin | Not assoc w R |
levofloxacin | Not assoc w R | |||||
rifampicin | Not assoc w R | |||||
isoniazid | Not assoc w R | |||||
fbiC | 1303728 | c.798G>C | synonymous_variant | 0.46 | clofazimine | |
pretomanid | ||||||
delamanid | ||||||
fbiC | 1303755 | c.825T>C | synonymous_variant | 0.4 | clofazimine | |
pretomanid | ||||||
delamanid | ||||||
fbiC | 1304811 | c.1881C>G | synonymous_variant | 0.5 | clofazimine | |
pretomanid | ||||||
delamanid | ||||||
fbiC | 1304817 | c.1887T>C | synonymous_variant | 0.47 | clofazimine | |
pretomanid | ||||||
delamanid | ||||||
Rv1258c | 1406760 | c.580_581insC | frameshift_variant | 1.0 | streptomycin | Uncertain significance |
isoniazid | Uncertain significance | |||||
pyrazinamide | Uncertain significance | |||||
atpE | 1461170 | c.126A>G | synonymous_variant | 0.37 | bedaquiline | |
atpE | 1461185 | c.141G>C | synonymous_variant | 0.35 | bedaquiline | |
atpE | 1461189 | c.145C>T | synonymous_variant | 0.4 | bedaquiline | |
atpE | 1461194 | c.150C>T | synonymous_variant | 0.42 | bedaquiline | |
atpE | 1461197 | c.153A>G | synonymous_variant | 0.47 | bedaquiline | |
atpE | 1461219 | c.175T>C | synonymous_variant | 0.5 | bedaquiline | |
atpE | 1461233 | c.189A>C | synonymous_variant | 0.5 | bedaquiline | |
rrs | 1471659 | n.-187C>T | upstream_gene_variant | 1.0 | streptomycin | |
kanamycin | ||||||
capreomycin | ||||||
amikacin | ||||||
rrs | 1471923 | n.78T>C | non_coding_transcript_exon_variant | 0.54 | streptomycin | Uncertain significance |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1471934 | n.89A>G | non_coding_transcript_exon_variant | 0.57 | streptomycin | Uncertain significance |
kanamycin | ||||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472108 | n.263C>T | non_coding_transcript_exon_variant | 0.42 | streptomycin | Uncertain significance |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472969 | n.1124A>G | non_coding_transcript_exon_variant | 0.42 | streptomycin | Uncertain significance |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472970 | n.1125C>G | non_coding_transcript_exon_variant | 0.44 | streptomycin | |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472977 | n.1132G>C | non_coding_transcript_exon_variant | 0.46 | streptomycin | |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472978 | n.1133T>C | non_coding_transcript_exon_variant | 0.46 | streptomycin | Uncertain significance |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1473104 | n.1259C>T | non_coding_transcript_exon_variant | 0.52 | streptomycin | Uncertain significance |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1473105 | n.1260G>A | non_coding_transcript_exon_variant | 0.5 | streptomycin | |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1473123 | n.1278delAinsTT | non_coding_transcript_exon_variant | 0.59 | streptomycin | |
kanamycin | ||||||
capreomycin | ||||||
amikacin | ||||||
rrs | 1473145 | n.1300C>T | non_coding_transcript_exon_variant | 0.55 | streptomycin | Uncertain significance |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1473166 | n.1321G>A | non_coding_transcript_exon_variant | 0.42 | streptomycin | Uncertain significance |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1473288 | n.1443C>T | non_coding_transcript_exon_variant | 0.44 | streptomycin | |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1473290 | n.1445C>T | non_coding_transcript_exon_variant | 0.44 | streptomycin | |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1473291 | n.1446G>T | non_coding_transcript_exon_variant | 0.46 | streptomycin | |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrl | 1473756 | n.99G>A | non_coding_transcript_exon_variant | 0.41 | capreomycin | |
linezolid | ||||||
rrl | 1473758 | n.101G>T | non_coding_transcript_exon_variant | 0.41 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1473839 | n.182G>T | non_coding_transcript_exon_variant | 0.43 | capreomycin | |
linezolid | ||||||
rrl | 1473877 | n.220G>A | non_coding_transcript_exon_variant | 0.53 | capreomycin | |
linezolid | ||||||
rrl | 1473898 | n.241C>T | non_coding_transcript_exon_variant | 0.45 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1473899 | n.242A>C | non_coding_transcript_exon_variant | 0.45 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1473936 | n.279A>G | non_coding_transcript_exon_variant | 0.47 | capreomycin | |
linezolid | ||||||
rrl | 1473943 | n.286G>T | non_coding_transcript_exon_variant | 0.45 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1473944 | n.287G>A | non_coding_transcript_exon_variant | 0.45 | capreomycin | |
linezolid | ||||||
rrl | 1474111 | n.454T>C | non_coding_transcript_exon_variant | 0.59 | capreomycin | |
linezolid | ||||||
rrl | 1474181 | n.524C>T | non_coding_transcript_exon_variant | 0.37 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1474639 | n.982G>A | non_coding_transcript_exon_variant | 0.54 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474794 | n.1137C>T | non_coding_transcript_exon_variant | 0.42 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474812 | n.1155G>A | non_coding_transcript_exon_variant | 0.5 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474823 | n.1166C>T | non_coding_transcript_exon_variant | 0.46 | capreomycin | |
linezolid | ||||||
rrl | 1474831 | n.1174A>G | non_coding_transcript_exon_variant | 0.39 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1474956 | n.1299C>T | non_coding_transcript_exon_variant | 0.42 | capreomycin | |
linezolid | ||||||
rrl | 1474960 | n.1303C>G | non_coding_transcript_exon_variant | 0.45 | capreomycin | |
linezolid | ||||||
rrl | 1474963 | n.1306G>T | non_coding_transcript_exon_variant | 0.43 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1474964 | n.1307T>A | non_coding_transcript_exon_variant | 0.45 | capreomycin | |
linezolid | ||||||
rrl | 1474965 | n.1308G>C | non_coding_transcript_exon_variant | 0.41 | capreomycin | |
linezolid | ||||||
rrl | 1474970 | n.1313G>A | non_coding_transcript_exon_variant | 0.43 | capreomycin | |
linezolid | ||||||
rrl | 1475088 | n.1431A>T | non_coding_transcript_exon_variant | 0.43 | capreomycin | |
linezolid | ||||||
rrl | 1475199 | n.1542G>A | non_coding_transcript_exon_variant | 0.44 | capreomycin | |
linezolid | ||||||
rrl | 1475201 | n.1544G>A | non_coding_transcript_exon_variant | 0.44 | capreomycin | |
linezolid | ||||||
rrl | 1475206 | n.1549C>T | non_coding_transcript_exon_variant | 0.39 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1475209 | n.1552G>C | non_coding_transcript_exon_variant | 0.41 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1475213 | n.1556C>T | non_coding_transcript_exon_variant | 0.43 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1475249 | n.1592T>C | non_coding_transcript_exon_variant | 0.26 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1475252 | n.1595C>T | non_coding_transcript_exon_variant | 0.29 | capreomycin | |
linezolid | ||||||
rrl | 1475266 | n.1609T>C | non_coding_transcript_exon_variant | 0.29 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1475267 | n.1610G>A | non_coding_transcript_exon_variant | 0.28 | capreomycin | |
linezolid | ||||||
rrl | 1475275 | n.1618C>T | non_coding_transcript_exon_variant | 0.28 | capreomycin | |
linezolid | ||||||
rrl | 1475276 | n.1619T>C | non_coding_transcript_exon_variant | 0.29 | capreomycin | |
linezolid | ||||||
rrl | 1475291 | n.1634A>C | non_coding_transcript_exon_variant | 0.4 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1475315 | n.1658A>T | non_coding_transcript_exon_variant | 0.48 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1475355 | n.1698C>T | non_coding_transcript_exon_variant | 0.69 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1475369 | n.1712G>C | non_coding_transcript_exon_variant | 0.66 | capreomycin | |
linezolid | ||||||
rrl | 1475402 | n.1745C>T | non_coding_transcript_exon_variant | 0.57 | capreomycin | |
linezolid | ||||||
rrl | 1475409 | n.1752T>C | non_coding_transcript_exon_variant | 0.54 | capreomycin | |
linezolid | ||||||
rrl | 1475419 | n.1762C>T | non_coding_transcript_exon_variant | 0.5 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1475429 | n.1772G>A | non_coding_transcript_exon_variant | 0.47 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1475483 | n.1826C>T | non_coding_transcript_exon_variant | 0.36 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1475505 | n.1848G>A | non_coding_transcript_exon_variant | 0.32 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1475526 | n.1869C>A | non_coding_transcript_exon_variant | 0.33 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1475599 | n.1942A>G | non_coding_transcript_exon_variant | 0.44 | capreomycin | |
linezolid | Uncertain significance | |||||
rrl | 1475608 | n.1951T>C | non_coding_transcript_exon_variant | 0.38 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1475638 | n.1981C>T | non_coding_transcript_exon_variant | 0.46 | capreomycin | |
linezolid | ||||||
rrl | 1475642 | n.1985T>C | non_coding_transcript_exon_variant | 0.42 | capreomycin | |
linezolid | ||||||
rrl | 1475761 | n.2104_2106delCGCinsGT | non_coding_transcript_exon_variant | 0.33 | capreomycin | |
linezolid | ||||||
rrl | 1475765 | n.2111delG | non_coding_transcript_exon_variant | 0.36 | capreomycin | |
linezolid | ||||||
rrl | 1475881 | n.2224T>C | non_coding_transcript_exon_variant | 0.63 | capreomycin | |
linezolid | ||||||
rrl | 1475988 | n.2331A>G | non_coding_transcript_exon_variant | 0.46 | capreomycin | Not assoc w R |
linezolid | Uncertain significance | |||||
rrl | 1476025 | n.2368G>T | non_coding_transcript_exon_variant | 0.33 | capreomycin | |
linezolid | ||||||
rrl | 1476045 | n.2388G>T | non_coding_transcript_exon_variant | 0.3 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1476047 | n.2390G>T | non_coding_transcript_exon_variant | 0.32 | capreomycin | |
linezolid | ||||||
rrl | 1476048 | n.2391G>A | non_coding_transcript_exon_variant | 0.32 | capreomycin | |
linezolid | ||||||
rrl | 1476049 | n.2392C>T | non_coding_transcript_exon_variant | 0.33 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476115 | n.2458T>C | non_coding_transcript_exon_variant | 0.29 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476117 | n.2460G>C | non_coding_transcript_exon_variant | 0.29 | capreomycin | |
linezolid | ||||||
rrl | 1476281 | n.2624T>C | non_coding_transcript_exon_variant | 0.41 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476297 | n.2640C>T | non_coding_transcript_exon_variant | 0.46 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476299 | n.2642C>T | non_coding_transcript_exon_variant | 0.46 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476583 | n.2926G>A | non_coding_transcript_exon_variant | 0.41 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1476584 | n.2927C>T | non_coding_transcript_exon_variant | 0.41 | capreomycin | Not assoc w R |
linezolid | Uncertain significance | |||||
rrl | 1476597 | n.2940G>A | non_coding_transcript_exon_variant | 0.39 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1476608 | n.2951C>G | non_coding_transcript_exon_variant | 0.48 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476628 | n.2971T>A | non_coding_transcript_exon_variant | 0.48 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476689 | n.3032A>T | non_coding_transcript_exon_variant | 0.47 | capreomycin | |
linezolid | ||||||
rrl | 1476690 | n.3033C>T | non_coding_transcript_exon_variant | 0.47 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1476693 | n.3036G>A | non_coding_transcript_exon_variant | 0.47 | capreomycin | |
linezolid | ||||||
rrl | 1476695 | n.3038T>A | non_coding_transcript_exon_variant | 0.47 | capreomycin | |
linezolid | ||||||
inhA | 1674690 | c.489C>G | synonymous_variant | 0.38 | ethionamide | |
isoniazid | ||||||
inhA | 1674703 | c.502T>C | synonymous_variant | 0.35 | ethionamide | |
isoniazid | ||||||
inhA | 1674708 | c.507G>A | synonymous_variant | 0.32 | ethionamide | |
isoniazid | ||||||
inhA | 1674714 | c.513C>G | synonymous_variant | 0.35 | ethionamide | |
isoniazid | ||||||
rpsA | 1833703 | c.162C>T | synonymous_variant | 0.61 | pyrazinamide | Not assoc w R - Interim |
rpsA | 1833724 | c.183C>G | synonymous_variant | 0.67 | pyrazinamide | |
rpsA | 1833727 | c.186G>C | synonymous_variant | 0.65 | pyrazinamide | |
rpsA | 1833742 | c.201A>G | synonymous_variant | 0.73 | pyrazinamide | |
rpsA | 1833745 | c.204G>C | synonymous_variant | 0.73 | pyrazinamide | |
rpsA | 1833760 | c.219C>T | synonymous_variant | 0.6 | pyrazinamide | Not assoc w R - Interim |
rpsA | 1833793 | c.252C>T | synonymous_variant | 0.59 | pyrazinamide | |
rpsA | 1833811 | c.270G>C | synonymous_variant | 0.62 | pyrazinamide | |
rpsA | 1833835 | c.294C>T | synonymous_variant | 0.62 | pyrazinamide | |
rpsA | 1833838 | c.297G>C | synonymous_variant | 0.58 | pyrazinamide | |
rpsA | 1833841 | c.300C>G | synonymous_variant | 0.56 | pyrazinamide | |
rpsA | 1833847 | c.306C>G | synonymous_variant | 0.59 | pyrazinamide | |
rpsA | 1833856 | c.315A>G | synonymous_variant | 0.64 | pyrazinamide | |
rpsA | 1833928 | c.387G>C | synonymous_variant | 0.4 | pyrazinamide | |
rpsA | 1833971 | c.430C>T | synonymous_variant | 0.33 | pyrazinamide | |
rpsA | 1833979 | c.438T>C | synonymous_variant | 0.27 | pyrazinamide | |
rpsA | 1834000 | c.459G>C | synonymous_variant | 0.31 | pyrazinamide | |
rpsA | 1834021 | c.480C>T | synonymous_variant | 0.44 | pyrazinamide | |
rpsA | 1834030 | c.489C>G | synonymous_variant | 0.41 | pyrazinamide | |
rpsA | 1834097 | c.556_557delTCinsAG | synonymous_variant | 0.44 | pyrazinamide | |
rpsA | 1834102 | c.561T>G | synonymous_variant | 0.38 | pyrazinamide | |
rpsA | 1834177 | c.636A>C | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
rpsA | 1834222 | c.681T>C | synonymous_variant | 0.39 | pyrazinamide | |
rpsA | 1834240 | c.699T>C | synonymous_variant | 0.5 | pyrazinamide | |
rpsA | 1834249 | c.708T>C | synonymous_variant | 0.52 | pyrazinamide | |
rpsA | 1834261 | c.720A>G | synonymous_variant | 0.53 | pyrazinamide | Not assoc w R - Interim |
rpsA | 1834264 | c.723G>C | synonymous_variant | 0.47 | pyrazinamide | |
rpsA | 1834294 | c.753G>T | synonymous_variant | 0.5 | pyrazinamide | |
rpsA | 1834297 | c.756C>T | synonymous_variant | 0.5 | pyrazinamide | |
rpsA | 1834303 | c.762T>C | synonymous_variant | 0.44 | pyrazinamide | |
rpsA | 1834306 | c.765T>C | synonymous_variant | 0.46 | pyrazinamide | |
rpsA | 1834348 | c.807T>C | synonymous_variant | 0.39 | pyrazinamide | Not assoc w R - Interim |
rpsA | 1834396 | c.855G>C | synonymous_variant | 0.44 | pyrazinamide | |
rpsA | 1834546 | c.1005T>C | synonymous_variant | 0.47 | pyrazinamide | |
rpsA | 1834633 | c.1092A>G | synonymous_variant | 0.34 | pyrazinamide | |
rpsA | 1834639 | c.1098T>C | synonymous_variant | 0.31 | pyrazinamide | |
rpsA | 1834738 | c.1197A>G | synonymous_variant | 0.4 | pyrazinamide | |
rpsA | 1834765 | p.Glu408Asp | missense_variant | 0.47 | pyrazinamide | |
PPE35 | 2167926 | p.Leu896Ser | missense_variant | 1.0 | pyrazinamide | Not assoc w R |
Rv1979c | 2223293 | c.-129A>G | upstream_gene_variant | 1.0 | clofazimine | Not assoc w R |
bedaquiline | Not assoc w R - Interim | |||||
kasA | 2518636 | c.522C>T | synonymous_variant | 0.36 | isoniazid | |
kasA | 2518642 | c.528A>G | synonymous_variant | 0.3 | isoniazid | |
kasA | 2518672 | c.558G>C | synonymous_variant | 0.3 | isoniazid | |
kasA | 2518678 | c.564C>T | synonymous_variant | 0.28 | isoniazid | |
ahpC | 2726633 | c.441C>G | synonymous_variant | 0.5 | isoniazid | |
ahpC | 2726638 | p.Ala149Val | missense_variant | 0.55 | isoniazid | |
ahpC | 2726645 | c.453C>G | synonymous_variant | 0.5 | isoniazid | |
ahpC | 2726651 | c.459G>C | synonymous_variant | 0.46 | isoniazid | |
ahpC | 2726657 | c.465A>C | synonymous_variant | 0.4 | isoniazid | Not assoc w R - Interim |
ahpC | 2726669 | p.Asp159Glu | missense_variant | 0.35 | isoniazid | |
ahpC | 2726675 | c.483A>G | synonymous_variant | 0.33 | isoniazid | |
ahpC | 2726681 | c.489A>C | synonymous_variant | 0.32 | isoniazid | Not assoc w R - Interim |
Rv2477c | 2782510 | c.1533G>C | synonymous_variant | 0.45 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
kanamycin | ||||||
rifampicin | ||||||
amikacin | ||||||
Rv2477c | 2782528 | c.1515G>C | synonymous_variant | 0.47 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
kanamycin | ||||||
rifampicin | ||||||
amikacin | ||||||
Rv2477c | 2782957 | c.1086A>G | synonymous_variant | 0.41 | ethambutol | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
streptomycin | Not assoc w R - Interim | |||||
levofloxacin | Not assoc w R - Interim | |||||
kanamycin | Not assoc w R - Interim | |||||
rifampicin | Not assoc w R - Interim | |||||
amikacin | Not assoc w R - Interim | |||||
Rv2477c | 2782969 | c.1074A>C | synonymous_variant | 0.38 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
kanamycin | ||||||
rifampicin | ||||||
amikacin | ||||||
Rv2477c | 2782981 | c.1062G>C | synonymous_variant | 0.27 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
kanamycin | ||||||
rifampicin | ||||||
amikacin | ||||||
Rv2477c | 2782984 | c.1059T>C | synonymous_variant | 0.29 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
kanamycin | ||||||
rifampicin | ||||||
amikacin | ||||||
Rv2477c | 2783002 | c.1041T>C | synonymous_variant | 0.28 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
kanamycin | ||||||
rifampicin | ||||||
amikacin | ||||||
Rv2477c | 2783008 | c.1035C>G | synonymous_variant | 0.3 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
kanamycin | ||||||
rifampicin | ||||||
amikacin | ||||||
Rv2477c | 2783013 | c.1030T>C | synonymous_variant | 0.32 | ethambutol | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
streptomycin | Not assoc w R - Interim | |||||
levofloxacin | Not assoc w R - Interim | |||||
kanamycin | Not assoc w R - Interim | |||||
rifampicin | Not assoc w R - Interim | |||||
amikacin | Not assoc w R - Interim | |||||
Rv2477c | 2783015 | p.Ser343Thr | missense_variant | 0.31 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
kanamycin | ||||||
rifampicin | ||||||
amikacin | ||||||
Rv2477c | 2783020 | c.1023G>C | synonymous_variant | 0.31 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
kanamycin | ||||||
rifampicin | ||||||
amikacin | ||||||
Rv2477c | 2783040 | p.Ala335Thr | missense_variant | 0.39 | ethambutol | Uncertain significance |
moxifloxacin | Uncertain significance | |||||
streptomycin | Uncertain significance | |||||
levofloxacin | Uncertain significance | |||||
kanamycin | Uncertain significance | |||||
rifampicin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
Rv2477c | 2783044 | c.999G>C | synonymous_variant | 0.38 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
kanamycin | ||||||
rifampicin | ||||||
amikacin | ||||||
Rv2477c | 2783051 | p.Tyr331Phe | missense_variant | 0.32 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
kanamycin | ||||||
rifampicin | ||||||
amikacin | ||||||
Rv2477c | 2783059 | c.984T>C | synonymous_variant | 0.33 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
kanamycin | ||||||
rifampicin | ||||||
amikacin | ||||||
Rv2477c | 2783065 | c.978C>T | synonymous_variant | 0.35 | ethambutol | Not assoc w R - Interim |
moxifloxacin | ||||||
streptomycin | Not assoc w R - Interim | |||||
levofloxacin | ||||||
kanamycin | ||||||
rifampicin | Not assoc w R - Interim | |||||
amikacin | ||||||
Rv2477c | 2783068 | p.Asp325Glu | missense_variant | 0.35 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
kanamycin | ||||||
rifampicin | ||||||
amikacin | ||||||
Rv2477c | 2783077 | c.966T>C | synonymous_variant | 0.42 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
kanamycin | ||||||
rifampicin | ||||||
amikacin | ||||||
Rv2477c | 2783086 | c.957C>T | synonymous_variant | 0.44 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
kanamycin | ||||||
rifampicin | ||||||
amikacin | ||||||
Rv2477c | 2783092 | c.951A>G | synonymous_variant | 0.43 | ethambutol | Not assoc w R - Interim |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
kanamycin | ||||||
rifampicin | Not assoc w R - Interim | |||||
amikacin | ||||||
Rv2477c | 2783095 | c.948C>G | synonymous_variant | 0.44 | ethambutol | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
streptomycin | Not assoc w R - Interim | |||||
levofloxacin | Not assoc w R - Interim | |||||
kanamycin | Not assoc w R - Interim | |||||
rifampicin | Not assoc w R | |||||
amikacin | Not assoc w R - Interim | |||||
Rv2477c | 2783116 | c.927T>C | synonymous_variant | 0.46 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
kanamycin | ||||||
rifampicin | ||||||
amikacin | ||||||
Rv2477c | 2783140 | c.903C>G | synonymous_variant | 0.42 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
kanamycin | ||||||
rifampicin | ||||||
amikacin | ||||||
Rv2477c | 2783149 | c.894G>C | synonymous_variant | 0.54 | ethambutol | |
moxifloxacin | Not assoc w R - Interim | |||||
streptomycin | ||||||
levofloxacin | Not assoc w R - Interim | |||||
kanamycin | Not assoc w R - Interim | |||||
rifampicin | Not assoc w R - Interim | |||||
amikacin | Not assoc w R - Interim | |||||
Rv2477c | 2783158 | c.885A>C | synonymous_variant | 0.5 | ethambutol | Not assoc w R - Interim |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | Not assoc w R - Interim | |||||
kanamycin | Not assoc w R - Interim | |||||
rifampicin | Not assoc w R - Interim | |||||
amikacin | Not assoc w R - Interim | |||||
Rv2477c | 2783182 | c.861C>G | synonymous_variant | 0.41 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
kanamycin | ||||||
rifampicin | ||||||
amikacin | ||||||
Rv2477c | 2783193 | p.Ser284Gly | missense_variant | 0.36 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
kanamycin | ||||||
rifampicin | ||||||
amikacin | ||||||
Rv2477c | 2783194 | c.849A>G | synonymous_variant | 0.36 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
kanamycin | ||||||
rifampicin | ||||||
amikacin | ||||||
Rv2477c | 2783203 | c.840C>T | synonymous_variant | 0.4 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
kanamycin | ||||||
rifampicin | ||||||
amikacin | ||||||
Rv2477c | 2783305 | c.738G>A | synonymous_variant | 0.35 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
kanamycin | ||||||
rifampicin | ||||||
amikacin | ||||||
Rv2477c | 2783311 | c.732T>C | synonymous_variant | 0.35 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
kanamycin | ||||||
rifampicin | ||||||
amikacin | ||||||
Rv2477c | 2783332 | c.711T>C | synonymous_variant | 0.33 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
kanamycin | ||||||
rifampicin | ||||||
amikacin | ||||||
Rv2477c | 2783335 | c.708C>G | synonymous_variant | 0.3 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
kanamycin | ||||||
rifampicin | ||||||
amikacin | ||||||
ald | 3086788 | c.-32T>C | upstream_gene_variant | 1.0 | cycloserine | |
Rv3236c | 3612813 | p.Thr102Ala | missense_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
mtrB | 3626562 | p.Pro18Ser | missense_variant | 1.0 | bedaquiline | Uncertain significance |
rifampicin | Not assoc w R | |||||
mtrB | 3627104 | c.-491C>G | upstream_gene_variant | 0.32 | bedaquiline | |
rifampicin | ||||||
mtrA | 3627119 | c.231T>G | synonymous_variant | 0.33 | bedaquiline | |
rifampicin | Not assoc w R - Interim | |||||
mtrB | 3627122 | c.-509T>C | upstream_gene_variant | 0.36 | bedaquiline | |
rifampicin | ||||||
mtrB | 3627128 | c.-515T>C | upstream_gene_variant | 0.35 | bedaquiline | |
rifampicin | ||||||
mtrB | 3627167 | c.-554T>C | upstream_gene_variant | 0.48 | bedaquiline | |
rifampicin | ||||||
mtrB | 3627181 | c.-568T>C | upstream_gene_variant | 0.47 | bedaquiline | |
rifampicin | ||||||
mtrB | 3627182 | c.-569T>C | upstream_gene_variant | 0.47 | bedaquiline | |
rifampicin | ||||||
mtrA | 3627187 | c.163T>C | synonymous_variant | 0.5 | bedaquiline | |
rifampicin | Not assoc w R - Interim | |||||
mtrA | 3627188 | c.162A>G | synonymous_variant | 0.5 | bedaquiline | |
rifampicin | Not assoc w R - Interim | |||||
rpoA | 3877656 | c.852T>C | synonymous_variant | 0.47 | rifampicin | Not assoc w R - Interim |
rpoA | 3877668 | c.840A>G | synonymous_variant | 0.5 | rifampicin | |
rpoA | 3877677 | p.Ala277Ser | missense_variant | 0.5 | rifampicin | |
rpoA | 3877704 | c.804G>C | synonymous_variant | 0.44 | rifampicin | |
rpoA | 3877737 | c.771G>C | synonymous_variant | 0.35 | rifampicin | |
rpoA | 3877770 | c.738A>G | synonymous_variant | 0.37 | rifampicin | Not assoc w R - Interim |
rpoA | 3877776 | c.732T>C | synonymous_variant | 0.34 | rifampicin | Not assoc w R - Interim |
rpoA | 3877782 | c.726T>C | synonymous_variant | 0.37 | rifampicin | Not assoc w R - Interim |
rpoA | 3878436 | c.72A>G | synonymous_variant | 0.35 | rifampicin | |
rpoA | 3878442 | c.66G>C | synonymous_variant | 0.38 | rifampicin | |
rpoA | 3878809 | c.-302T>C | upstream_gene_variant | 0.32 | rifampicin | |
rpoA | 3878833 | c.-326C>G | upstream_gene_variant | 0.33 | rifampicin | |
rpoA | 3878845 | c.-338G>T | upstream_gene_variant | 0.36 | rifampicin | |
rpoA | 3878853 | c.-346G>A | upstream_gene_variant | 0.36 | rifampicin | |
rpoA | 3878862 | c.-355T>C | upstream_gene_variant | 0.3 | rifampicin | |
rpoA | 3878878 | c.-371T>C | upstream_gene_variant | 0.32 | rifampicin | Uncertain significance |
clpC1 | 4038359 | c.2346A>G | synonymous_variant | 0.4 | pyrazinamide | |
clpC1 | 4038368 | c.2337T>C | synonymous_variant | 0.38 | pyrazinamide | |
clpC1 | 4038388 | c.2317T>C | synonymous_variant | 0.32 | pyrazinamide | |
clpC1 | 4038392 | c.2313C>T | synonymous_variant | 0.32 | pyrazinamide | |
clpC1 | 4038671 | c.2034T>C | synonymous_variant | 0.44 | pyrazinamide | |
clpC1 | 4038683 | c.2022T>C | synonymous_variant | 0.39 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4038740 | c.1965G>C | synonymous_variant | 0.35 | pyrazinamide | |
clpC1 | 4038755 | c.1950G>T | synonymous_variant | 0.3 | pyrazinamide | |
clpC1 | 4038773 | c.1932T>C | synonymous_variant | 0.32 | pyrazinamide | |
clpC1 | 4038790 | c.1915C>T | synonymous_variant | 0.39 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4038812 | c.1893T>C | synonymous_variant | 0.42 | pyrazinamide | |
clpC1 | 4038815 | c.1890G>C | synonymous_variant | 0.42 | pyrazinamide | |
clpC1 | 4039064 | c.1641C>T | synonymous_variant | 0.38 | pyrazinamide | |
clpC1 | 4039898 | c.807C>G | synonymous_variant | 0.33 | pyrazinamide | |
clpC1 | 4039904 | c.801A>G | synonymous_variant | 0.38 | pyrazinamide | |
clpC1 | 4039931 | c.774T>C | synonymous_variant | 0.3 | pyrazinamide | |
clpC1 | 4039946 | c.759A>T | synonymous_variant | 0.33 | pyrazinamide | |
clpC1 | 4039952 | c.753T>C | synonymous_variant | 0.35 | pyrazinamide | |
embA | 4245182 | c.1950T>C | synonymous_variant | 0.33 | ethambutol | |
embA | 4245186 | p.Thr652Ala | missense_variant | 0.33 | ethambutol | |
aftB | 4267647 | p.Asp397Gly | missense_variant | 0.91 | ethambutol | Not assoc w R |
whiB6 | 4338595 | c.-75delG | upstream_gene_variant | 1.0 | capreomycin | Not assoc w R |
amikacin | Not assoc w R | |||||
kanamycin | Not assoc w R | |||||
gid | 4407588 | c.615A>G | synonymous_variant | 1.0 | streptomycin | Not assoc w R |
gid | 4407620 | p.Tyr195His | missense_variant | 1.0 | streptomycin | Not assoc w R |