TB-Profiler

Lineage	Family	RDs	Frequency
lineage4	Euro-American	None	1.0
lineage4.8	Euro-American (mainly T)	RD219	0.99

Gene	Chromosome position	Mutation	Type	Estimated fraction	Drugs	Confidence	Comment
rrs	1473247	n.1402C>A	non_coding_transcript_exon_variant	0.78	amikacin	Uncertain significance	Mutation from literature
kanamycin	Uncertain significance	Mutation from literature
capreomycin	Uncertain significance	Mutation from literature
rrs	1473329	n.1484G>T	non_coding_transcript_exon_variant	0.63	amikacin	Assoc w R
kanamycin	Assoc w R
capreomycin	Assoc w R

Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance

Gene	Chromosome position	Mutation	Type	Estimated fraction	Drugs	Confidence
gyrA	7362	p.Glu21Gln	missense_variant	1.0	levofloxacin	Not assoc w R
gyrA	7362	p.Glu21Gln	missense_variant	1.0	moxifloxacin	Not assoc w R
rpoB	762878	p.Ile1024Met	missense_variant	0.34	rifampicin
rpoB	762879	p.Met1025Leu	missense_variant	0.35	rifampicin	Uncertain significance
rpoC	762899	c.-471G>T	upstream_gene_variant	0.36	rifampicin
rpoB	762920	c.3114C>T	synonymous_variant	0.4	rifampicin	Not assoc w R - Interim
rpoB	762929	c.3123G>C	synonymous_variant	0.45	rifampicin	Not assoc w R - Interim
rpoC	762959	c.-411G>T	upstream_gene_variant	0.5	rifampicin
rpoC	762971	c.-399G>C	upstream_gene_variant	0.46	rifampicin
rpoC	762983	c.-387C>T	upstream_gene_variant	0.4	rifampicin
rpoB	762989	c.3183G>A	synonymous_variant	0.36	rifampicin	Not assoc w R - Interim
rpoB	762995	c.3189G>T	synonymous_variant	0.35	rifampicin	Not assoc w R - Interim
rpoB	763002	c.3197dupA	frameshift_variant	0.33	rifampicin
rpoB	763006	c.3201delC	frameshift_variant	0.28	rifampicin
rpoB	763017	p.Gln1071Glu	missense_variant	0.25	rifampicin
rpoC	763528	c.159G>A	synonymous_variant	0.37	rifampicin	Not assoc w R - Interim
rpoC	763534	c.165T>C	synonymous_variant	0.48	rifampicin
rpoC	763537	c.168C>G	synonymous_variant	0.49	rifampicin
rpoC	763546	c.177A>G	synonymous_variant	0.48	rifampicin	Not assoc w R - Interim
rpoC	763570	c.201G>C	synonymous_variant	0.5	rifampicin	Not assoc w R - Interim
rpoC	763573	c.204G>C	synonymous_variant	0.5	rifampicin	Not assoc w R - Interim
rpoC	763594	c.225C>T	synonymous_variant	0.47	rifampicin	Not assoc w R - Interim
rpoC	763622	p.Ala85Ser	missense_variant	0.36	rifampicin	Uncertain significance
rpoC	763627	p.Lys86Asn	missense_variant	0.36	rifampicin	Uncertain significance
rpoC	763642	c.273G>T	synonymous_variant	0.27	rifampicin
mmpL5	775639	p.Ile948Val	missense_variant	1.0	clofazimine	Not assoc w R
mmpL5	775639	p.Ile948Val	missense_variant	1.0	bedaquiline	Not assoc w R - Interim
rpsL	781395	c.-165T>C	upstream_gene_variant	1.0	streptomycin	Not assoc w R
fbiC	1303747	p.Thr273Ala	missense_variant	1.0	clofazimine	Uncertain significance
					pretomanid
					delamanid	Uncertain significance
rrs	1471659	n.-187C>T	upstream_gene_variant	1.0	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472106	n.261G>A	non_coding_transcript_exon_variant	0.24	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1472107	n.262A>G	non_coding_transcript_exon_variant	0.24	streptomycin
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472108	n.263C>T	non_coding_transcript_exon_variant	0.24	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472112	n.267C>T	non_coding_transcript_exon_variant	0.37	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472122	n.277G>T	non_coding_transcript_exon_variant	0.4	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472123	n.278A>T	non_coding_transcript_exon_variant	0.4	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472124	n.279C>T	non_coding_transcript_exon_variant	0.4	streptomycin
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472150	n.305T>A	non_coding_transcript_exon_variant	0.57	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Not assoc w R
					amikacin	Not assoc w R
rrs	1472160	n.315C>T	non_coding_transcript_exon_variant	0.68	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472225	n.380C>G	non_coding_transcript_exon_variant	0.62	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472240	n.395G>A	non_coding_transcript_exon_variant	0.56	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472251	n.406G>C	non_coding_transcript_exon_variant	0.53	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472279	n.434T>G	non_coding_transcript_exon_variant	0.24	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472285	n.440A>G	non_coding_transcript_exon_variant	0.2	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472344	n.499C>T	non_coding_transcript_exon_variant	0.29	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Not assoc w R
					amikacin	Not assoc w R
rrs	1472368	n.523A>G	non_coding_transcript_exon_variant	0.41	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472396	n.551A>T	non_coding_transcript_exon_variant	0.27	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472400	n.555C>T	non_coding_transcript_exon_variant	0.29	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Not assoc w R
					amikacin	Not assoc w R
rrs	1472412	n.567A>G	non_coding_transcript_exon_variant	0.14	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472498	n.653C>T	non_coding_transcript_exon_variant	0.17	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472507	n.662C>A	non_coding_transcript_exon_variant	0.39	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472522	n.677T>G	non_coding_transcript_exon_variant	0.58	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472557	n.712G>A	non_coding_transcript_exon_variant	0.79	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472571	n.726G>T	non_coding_transcript_exon_variant	0.78	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472581	n.736A>C	non_coding_transcript_exon_variant	0.78	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472582	n.737G>T	non_coding_transcript_exon_variant	0.77	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472584	n.739A>T	non_coding_transcript_exon_variant	0.76	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472585	n.740A>C	non_coding_transcript_exon_variant	0.76	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472623	n.778A>C	non_coding_transcript_exon_variant	0.78	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472647	n.802C>T	non_coding_transcript_exon_variant	0.76	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472673	n.828T>G	non_coding_transcript_exon_variant	0.71	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472675	n.830T>C	non_coding_transcript_exon_variant	0.69	streptomycin
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472677	n.832C>A	non_coding_transcript_exon_variant	0.69	streptomycin
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472682	n.837T>A	non_coding_transcript_exon_variant	0.71	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472683	n.838T>C	non_coding_transcript_exon_variant	0.71	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472687	n.842A>T	non_coding_transcript_exon_variant	0.71	streptomycin
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472707	n.862A>T	non_coding_transcript_exon_variant	0.71	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472767	n.922G>C	non_coding_transcript_exon_variant	0.58	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472790	n.945T>C	non_coding_transcript_exon_variant	0.51	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472812	n.967A>T	non_coding_transcript_exon_variant	0.37	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472954	n.1110delC	non_coding_transcript_exon_variant	0.68	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472958	n.1113_1114insC	non_coding_transcript_exon_variant	0.68	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472973	n.1128A>T	non_coding_transcript_exon_variant	0.71	streptomycin
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472986	n.1141_1142insA	non_coding_transcript_exon_variant	0.71	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472989	n.1145delA	non_coding_transcript_exon_variant	0.7	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472996	n.1151T>C	non_coding_transcript_exon_variant	0.71	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473066	n.1221A>G	non_coding_transcript_exon_variant	0.61	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473081	n.1236C>T	non_coding_transcript_exon_variant	0.51	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473088	n.1243A>G	non_coding_transcript_exon_variant	0.37	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473091	n.1246G>A	non_coding_transcript_exon_variant	0.29	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473093	n.1248C>T	non_coding_transcript_exon_variant	0.3	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473094	n.1249T>G	non_coding_transcript_exon_variant	0.3	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1473099	n.1254T>G	non_coding_transcript_exon_variant	0.31	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473100	n.1255G>C	non_coding_transcript_exon_variant	0.3	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1473102	n.1257C>T	non_coding_transcript_exon_variant	0.3	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473104	n.1259C>T	non_coding_transcript_exon_variant	0.3	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473109	n.1264T>G	non_coding_transcript_exon_variant	0.29	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1473111	n.1266A>G	non_coding_transcript_exon_variant	0.3	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473120	n.1275C>T	non_coding_transcript_exon_variant	0.34	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473121	n.1276T>C	non_coding_transcript_exon_variant	0.35	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Not assoc w R
					amikacin	Not assoc w R
rrs	1473122	n.1277T>G	non_coding_transcript_exon_variant	0.35	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1473123	n.1278A>G	non_coding_transcript_exon_variant	0.35	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473145	n.1300C>T	non_coding_transcript_exon_variant	0.51	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473164	n.1319C>T	non_coding_transcript_exon_variant	0.55	streptomycin	Uncertain significance
					kanamycin
					capreomycin
					amikacin
rrs	1473166	n.1321G>A	non_coding_transcript_exon_variant	0.57	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473226	n.1381C>G	non_coding_transcript_exon_variant	0.77	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1473259	n.1414C>T	non_coding_transcript_exon_variant	0.76	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1473276	n.1431A>G	non_coding_transcript_exon_variant	0.71	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473288	n.1443C>G	non_coding_transcript_exon_variant	0.7	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473290	n.1445C>T	non_coding_transcript_exon_variant	0.69	streptomycin
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473292	n.1447G>T	non_coding_transcript_exon_variant	0.69	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1473294	n.1449A>G	non_coding_transcript_exon_variant	0.7	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473301	n.1456T>C	non_coding_transcript_exon_variant	0.69	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473315	n.1470T>C	non_coding_transcript_exon_variant	0.62	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473316	n.1471C>T	non_coding_transcript_exon_variant	0.59	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473319	n.1474C>T	non_coding_transcript_exon_variant	0.63	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473324	n.1479G>A	non_coding_transcript_exon_variant	0.63	streptomycin
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin
rrl	1474001	n.344C>T	non_coding_transcript_exon_variant	1.0	capreomycin	Not assoc w R
rrl	1474001	n.344C>T	non_coding_transcript_exon_variant	1.0	linezolid	Not assoc w R
rrl	1474166	n.509G>T	non_coding_transcript_exon_variant	0.16	capreomycin
rrl	1474166	n.509G>T	non_coding_transcript_exon_variant	0.16	linezolid
rrl	1474167	n.510T>C	non_coding_transcript_exon_variant	0.16	capreomycin
rrl	1474167	n.510T>C	non_coding_transcript_exon_variant	0.16	linezolid
rrl	1474184	n.527C>T	non_coding_transcript_exon_variant	0.3	capreomycin	Uncertain significance
rrl	1474184	n.527C>T	non_coding_transcript_exon_variant	0.3	linezolid	Uncertain significance
rrl	1474186	n.529A>G	non_coding_transcript_exon_variant	0.3	capreomycin	Uncertain significance
rrl	1474186	n.529A>G	non_coding_transcript_exon_variant	0.3	linezolid	Uncertain significance
rrl	1474197	n.540C>T	non_coding_transcript_exon_variant	0.41	capreomycin	Uncertain significance
rrl	1474197	n.540C>T	non_coding_transcript_exon_variant	0.41	linezolid
rrl	1474202	n.545T>G	non_coding_transcript_exon_variant	0.46	capreomycin
rrl	1474202	n.545T>G	non_coding_transcript_exon_variant	0.46	linezolid
rrl	1474218	n.561T>G	non_coding_transcript_exon_variant	0.53	capreomycin
rrl	1474218	n.561T>G	non_coding_transcript_exon_variant	0.53	linezolid
rrl	1474253	n.596A>T	non_coding_transcript_exon_variant	0.37	capreomycin	Uncertain significance
rrl	1474253	n.596A>T	non_coding_transcript_exon_variant	0.37	linezolid	Uncertain significance
rrl	1474264	n.607T>G	non_coding_transcript_exon_variant	0.34	capreomycin
rrl	1474264	n.607T>G	non_coding_transcript_exon_variant	0.34	linezolid
rrl	1474265	n.608G>T	non_coding_transcript_exon_variant	0.34	capreomycin
rrl	1474265	n.608G>T	non_coding_transcript_exon_variant	0.34	linezolid
rrl	1474266	n.609T>C	non_coding_transcript_exon_variant	0.34	capreomycin	Uncertain significance
rrl	1474266	n.609T>C	non_coding_transcript_exon_variant	0.34	linezolid	Uncertain significance
rrl	1474269	n.612C>A	non_coding_transcript_exon_variant	0.34	capreomycin
rrl	1474269	n.612C>A	non_coding_transcript_exon_variant	0.34	linezolid
rrl	1474271	n.614A>G	non_coding_transcript_exon_variant	0.34	capreomycin
rrl	1474271	n.614A>G	non_coding_transcript_exon_variant	0.34	linezolid
rrl	1474275	n.618T>G	non_coding_transcript_exon_variant	0.35	capreomycin
rrl	1474275	n.618T>G	non_coding_transcript_exon_variant	0.35	linezolid
rrl	1474287	n.631_649delCCTTTTCCTCTCCGGAGGA	non_coding_transcript_exon_variant	0.37	capreomycin
rrl	1474287	n.631_649delCCTTTTCCTCTCCGGAGGA	non_coding_transcript_exon_variant	0.37	linezolid
rrl	1474308	n.651G>T	non_coding_transcript_exon_variant	0.34	capreomycin	Uncertain significance
rrl	1474308	n.651G>T	non_coding_transcript_exon_variant	0.34	linezolid	Uncertain significance
rrl	1474348	n.691C>T	non_coding_transcript_exon_variant	0.28	capreomycin	Uncertain significance
rrl	1474348	n.691C>T	non_coding_transcript_exon_variant	0.28	linezolid	Uncertain significance
rrl	1474351	n.694G>T	non_coding_transcript_exon_variant	0.27	capreomycin	Uncertain significance
rrl	1474351	n.694G>T	non_coding_transcript_exon_variant	0.27	linezolid	Uncertain significance
rrl	1474454	n.797G>A	non_coding_transcript_exon_variant	0.25	capreomycin	Uncertain significance
rrl	1474454	n.797G>A	non_coding_transcript_exon_variant	0.25	linezolid	Uncertain significance
rrl	1474467	n.810A>T	non_coding_transcript_exon_variant	0.32	capreomycin
rrl	1474467	n.810A>T	non_coding_transcript_exon_variant	0.32	linezolid
rrl	1474476	n.819C>T	non_coding_transcript_exon_variant	0.4	capreomycin
rrl	1474476	n.819C>T	non_coding_transcript_exon_variant	0.4	linezolid
rrl	1474488	n.831G>A	non_coding_transcript_exon_variant	0.49	capreomycin
rrl	1474488	n.831G>A	non_coding_transcript_exon_variant	0.49	linezolid
rrl	1474496	n.839C>T	non_coding_transcript_exon_variant	0.52	capreomycin
rrl	1474496	n.839C>T	non_coding_transcript_exon_variant	0.52	linezolid
rrl	1474497	n.840G>C	non_coding_transcript_exon_variant	0.53	capreomycin	Uncertain significance
rrl	1474497	n.840G>C	non_coding_transcript_exon_variant	0.53	linezolid	Uncertain significance
rrl	1474506	n.849C>G	non_coding_transcript_exon_variant	0.55	capreomycin	Uncertain significance
rrl	1474506	n.849C>G	non_coding_transcript_exon_variant	0.55	linezolid	Uncertain significance
rrl	1474507	n.850G>T	non_coding_transcript_exon_variant	0.55	capreomycin	Uncertain significance
rrl	1474507	n.850G>T	non_coding_transcript_exon_variant	0.55	linezolid	Uncertain significance
rrl	1474516	n.859C>T	non_coding_transcript_exon_variant	0.56	capreomycin
rrl	1474516	n.859C>T	non_coding_transcript_exon_variant	0.56	linezolid
rrl	1474529	n.872A>C	non_coding_transcript_exon_variant	0.57	capreomycin
rrl	1474529	n.872A>C	non_coding_transcript_exon_variant	0.57	linezolid
rrl	1474530	n.873G>A	non_coding_transcript_exon_variant	0.57	capreomycin
rrl	1474530	n.873G>A	non_coding_transcript_exon_variant	0.57	linezolid
rrl	1474537	n.880G>A	non_coding_transcript_exon_variant	0.57	capreomycin	Uncertain significance
rrl	1474537	n.880G>A	non_coding_transcript_exon_variant	0.57	linezolid	Uncertain significance
rrl	1474539	n.882C>T	non_coding_transcript_exon_variant	0.55	capreomycin
rrl	1474539	n.882C>T	non_coding_transcript_exon_variant	0.55	linezolid
rrl	1474540	n.883T>G	non_coding_transcript_exon_variant	0.57	capreomycin
rrl	1474540	n.883T>G	non_coding_transcript_exon_variant	0.57	linezolid
rrl	1474552	n.895C>T	non_coding_transcript_exon_variant	0.55	capreomycin
rrl	1474552	n.895C>T	non_coding_transcript_exon_variant	0.55	linezolid
rrl	1474558	n.901G>A	non_coding_transcript_exon_variant	0.56	capreomycin	Uncertain significance
rrl	1474558	n.901G>A	non_coding_transcript_exon_variant	0.56	linezolid
rrl	1474582	n.925T>A	non_coding_transcript_exon_variant	0.67	capreomycin
rrl	1474582	n.925T>A	non_coding_transcript_exon_variant	0.67	linezolid
rrl	1474749	n.1092C>T	non_coding_transcript_exon_variant	0.48	capreomycin	Uncertain significance
rrl	1474749	n.1092C>T	non_coding_transcript_exon_variant	0.48	linezolid	Uncertain significance
rrl	1474752	n.1096delA	non_coding_transcript_exon_variant	0.48	capreomycin
rrl	1474752	n.1096delA	non_coding_transcript_exon_variant	0.48	linezolid
rrl	1474760	n.1103A>G	non_coding_transcript_exon_variant	0.51	capreomycin	Uncertain significance
rrl	1474760	n.1103A>G	non_coding_transcript_exon_variant	0.51	linezolid	Uncertain significance
rrl	1474779	n.1122G>A	non_coding_transcript_exon_variant	0.51	capreomycin	Uncertain significance
rrl	1474779	n.1122G>A	non_coding_transcript_exon_variant	0.51	linezolid	Uncertain significance
rrl	1474780	n.1123C>T	non_coding_transcript_exon_variant	0.51	capreomycin	Uncertain significance
rrl	1474780	n.1123C>T	non_coding_transcript_exon_variant	0.51	linezolid	Uncertain significance
rrl	1474782	n.1125G>A	non_coding_transcript_exon_variant	0.51	capreomycin	Not assoc w R
rrl	1474782	n.1125G>A	non_coding_transcript_exon_variant	0.51	linezolid	Uncertain significance
rrl	1474794	n.1137C>T	non_coding_transcript_exon_variant	0.5	capreomycin	Uncertain significance
rrl	1474794	n.1137C>T	non_coding_transcript_exon_variant	0.5	linezolid	Uncertain significance
rrl	1474798	n.1141C>T	non_coding_transcript_exon_variant	0.53	capreomycin	Uncertain significance
rrl	1474798	n.1141C>T	non_coding_transcript_exon_variant	0.53	linezolid	Uncertain significance
rrl	1474799	n.1143delT	non_coding_transcript_exon_variant	0.55	capreomycin
rrl	1474799	n.1143delT	non_coding_transcript_exon_variant	0.55	linezolid
rrl	1474803	n.1146_1147insA	non_coding_transcript_exon_variant	0.54	capreomycin
rrl	1474803	n.1146_1147insA	non_coding_transcript_exon_variant	0.54	linezolid
rrl	1474806	n.1149A>C	non_coding_transcript_exon_variant	0.58	capreomycin
rrl	1474806	n.1149A>C	non_coding_transcript_exon_variant	0.58	linezolid
rrl	1474823	n.1166C>G	non_coding_transcript_exon_variant	0.72	capreomycin	Uncertain significance
rrl	1474823	n.1166C>G	non_coding_transcript_exon_variant	0.72	linezolid	Uncertain significance
rrl	1474827	n.1170C>T	non_coding_transcript_exon_variant	0.7	capreomycin	Uncertain significance
rrl	1474827	n.1170C>T	non_coding_transcript_exon_variant	0.7	linezolid	Uncertain significance
rrl	1474830	n.1173A>G	non_coding_transcript_exon_variant	0.7	capreomycin	Uncertain significance
rrl	1474830	n.1173A>G	non_coding_transcript_exon_variant	0.7	linezolid	Uncertain significance
rrl	1474831	n.1174A>T	non_coding_transcript_exon_variant	0.7	capreomycin	Uncertain significance
rrl	1474831	n.1174A>T	non_coding_transcript_exon_variant	0.7	linezolid	Uncertain significance
rrl	1474853	n.1196A>G	non_coding_transcript_exon_variant	0.71	capreomycin
rrl	1474853	n.1196A>G	non_coding_transcript_exon_variant	0.71	linezolid
rrl	1474864	n.1207C>T	non_coding_transcript_exon_variant	0.73	capreomycin	Not assoc w R
rrl	1474864	n.1207C>T	non_coding_transcript_exon_variant	0.73	linezolid	Uncertain significance
rrl	1474904	n.1247G>C	non_coding_transcript_exon_variant	0.63	capreomycin	Uncertain significance
rrl	1474904	n.1247G>C	non_coding_transcript_exon_variant	0.63	linezolid	Uncertain significance
rrl	1474905	n.1248T>C	non_coding_transcript_exon_variant	0.61	capreomycin	Uncertain significance
rrl	1474905	n.1248T>C	non_coding_transcript_exon_variant	0.61	linezolid	Uncertain significance
rrl	1474928	n.1271C>T	non_coding_transcript_exon_variant	0.24	capreomycin
rrl	1474928	n.1271C>T	non_coding_transcript_exon_variant	0.24	linezolid
rrl	1475673	n.2016T>C	non_coding_transcript_exon_variant	0.35	capreomycin	Uncertain significance
rrl	1475673	n.2016T>C	non_coding_transcript_exon_variant	0.35	linezolid	Uncertain significance
rrl	1475699	n.2042C>T	non_coding_transcript_exon_variant	0.62	capreomycin	Uncertain significance
rrl	1475699	n.2042C>T	non_coding_transcript_exon_variant	0.62	linezolid	Uncertain significance
rrl	1475722	n.2065G>T	non_coding_transcript_exon_variant	0.7	capreomycin
rrl	1475722	n.2065G>T	non_coding_transcript_exon_variant	0.7	linezolid
rrl	1475747	n.2090A>G	non_coding_transcript_exon_variant	0.61	capreomycin	Uncertain significance
rrl	1475747	n.2090A>G	non_coding_transcript_exon_variant	0.61	linezolid	Uncertain significance
rrl	1475751	n.2094C>A	non_coding_transcript_exon_variant	0.55	capreomycin
rrl	1475751	n.2094C>A	non_coding_transcript_exon_variant	0.55	linezolid
rrl	1475753	n.2096C>T	non_coding_transcript_exon_variant	0.55	capreomycin	Uncertain significance
rrl	1475753	n.2096C>T	non_coding_transcript_exon_variant	0.55	linezolid
rrl	1475756	n.2099_2107delTAACCCGCAinsG	non_coding_transcript_exon_variant	0.57	capreomycin
rrl	1475756	n.2099_2107delTAACCCGCAinsG	non_coding_transcript_exon_variant	0.57	linezolid
rrl	1475767	n.2110G>T	non_coding_transcript_exon_variant	0.55	capreomycin
rrl	1475767	n.2110G>T	non_coding_transcript_exon_variant	0.55	linezolid	Uncertain significance
rrl	1475770	n.2113_2114delGAinsATGCGT	non_coding_transcript_exon_variant	0.56	capreomycin
rrl	1475770	n.2113_2114delGAinsATGCGT	non_coding_transcript_exon_variant	0.56	linezolid
rrl	1475777	n.2120A>T	non_coding_transcript_exon_variant	0.58	capreomycin
rrl	1475777	n.2120A>T	non_coding_transcript_exon_variant	0.58	linezolid
rrl	1475781	n.2124T>C	non_coding_transcript_exon_variant	0.6	capreomycin	Uncertain significance
rrl	1475781	n.2124T>C	non_coding_transcript_exon_variant	0.6	linezolid
rrl	1475869	n.2212C>A	non_coding_transcript_exon_variant	0.7	capreomycin
rrl	1475869	n.2212C>A	non_coding_transcript_exon_variant	0.7	linezolid
rrl	1475877	n.2220C>T	non_coding_transcript_exon_variant	0.69	capreomycin	Uncertain significance
rrl	1475877	n.2220C>T	non_coding_transcript_exon_variant	0.69	linezolid
rrl	1475881	n.2224T>C	non_coding_transcript_exon_variant	0.68	capreomycin
rrl	1475881	n.2224T>C	non_coding_transcript_exon_variant	0.68	linezolid
rrl	1475883	n.2226A>T	non_coding_transcript_exon_variant	0.69	capreomycin	Uncertain significance
rrl	1475883	n.2226A>T	non_coding_transcript_exon_variant	0.69	linezolid	Uncertain significance
rrl	1475892	n.2235A>C	non_coding_transcript_exon_variant	0.71	capreomycin
rrl	1475892	n.2235A>C	non_coding_transcript_exon_variant	0.71	linezolid
rrl	1475898	n.2241A>G	non_coding_transcript_exon_variant	0.68	capreomycin	Uncertain significance
rrl	1475898	n.2241A>G	non_coding_transcript_exon_variant	0.68	linezolid
rrl	1475899	n.2242G>A	non_coding_transcript_exon_variant	0.68	capreomycin	Uncertain significance
rrl	1475899	n.2242G>A	non_coding_transcript_exon_variant	0.68	linezolid
rrl	1475906	n.2249C>T	non_coding_transcript_exon_variant	0.72	capreomycin	Uncertain significance
rrl	1475906	n.2249C>T	non_coding_transcript_exon_variant	0.72	linezolid	Uncertain significance
rrl	1475916	n.2259C>T	non_coding_transcript_exon_variant	0.69	capreomycin	Uncertain significance
rrl	1475916	n.2259C>T	non_coding_transcript_exon_variant	0.69	linezolid	Uncertain significance
rrl	1475943	n.2286G>A	non_coding_transcript_exon_variant	0.68	capreomycin	Uncertain significance
rrl	1475943	n.2286G>A	non_coding_transcript_exon_variant	0.68	linezolid	Uncertain significance
rrl	1475952	n.2295A>G	non_coding_transcript_exon_variant	0.64	capreomycin	Uncertain significance
rrl	1475952	n.2295A>G	non_coding_transcript_exon_variant	0.64	linezolid	Uncertain significance
rrl	1475970	n.2313C>T	non_coding_transcript_exon_variant	0.56	capreomycin	Uncertain significance
rrl	1475970	n.2313C>T	non_coding_transcript_exon_variant	0.56	linezolid	Uncertain significance
rrl	1475975	n.2318C>T	non_coding_transcript_exon_variant	0.55	capreomycin	Uncertain significance
rrl	1475975	n.2318C>T	non_coding_transcript_exon_variant	0.55	linezolid	Uncertain significance
rrl	1475977	n.2320A>G	non_coding_transcript_exon_variant	0.48	capreomycin	Uncertain significance
rrl	1475977	n.2320A>G	non_coding_transcript_exon_variant	0.48	linezolid	Uncertain significance
rrl	1475978	n.2321C>T	non_coding_transcript_exon_variant	0.48	capreomycin	Uncertain significance
rrl	1475978	n.2321C>T	non_coding_transcript_exon_variant	0.48	linezolid	Uncertain significance
rrl	1475988	n.2331A>G	non_coding_transcript_exon_variant	0.46	capreomycin	Not assoc w R
rrl	1475988	n.2331A>G	non_coding_transcript_exon_variant	0.46	linezolid	Uncertain significance
rrl	1475991	n.2334T>A	non_coding_transcript_exon_variant	0.46	capreomycin
rrl	1475991	n.2334T>A	non_coding_transcript_exon_variant	0.46	linezolid
rrl	1475993	n.2336C>T	non_coding_transcript_exon_variant	0.46	capreomycin	Uncertain significance
rrl	1475993	n.2336C>T	non_coding_transcript_exon_variant	0.46	linezolid	Uncertain significance
rrl	1475996	n.2339T>G	non_coding_transcript_exon_variant	0.47	capreomycin
rrl	1475996	n.2339T>G	non_coding_transcript_exon_variant	0.47	linezolid
rrl	1476115	n.2458T>C	non_coding_transcript_exon_variant	0.17	capreomycin	Uncertain significance
rrl	1476115	n.2458T>C	non_coding_transcript_exon_variant	0.17	linezolid	Uncertain significance
rrl	1476117	n.2460G>A	non_coding_transcript_exon_variant	0.17	capreomycin
rrl	1476117	n.2460G>A	non_coding_transcript_exon_variant	0.17	linezolid
rrl	1476130	n.2473G>A	non_coding_transcript_exon_variant	0.4	capreomycin	Uncertain significance
rrl	1476130	n.2473G>A	non_coding_transcript_exon_variant	0.4	linezolid	Uncertain significance
rrl	1476131	n.2474C>T	non_coding_transcript_exon_variant	0.4	capreomycin	Uncertain significance
rrl	1476131	n.2474C>T	non_coding_transcript_exon_variant	0.4	linezolid	Uncertain significance
rrl	1476141	n.2484A>G	non_coding_transcript_exon_variant	0.5	capreomycin	Uncertain significance
rrl	1476141	n.2484A>G	non_coding_transcript_exon_variant	0.5	linezolid	Uncertain significance
rrl	1476153	n.2496T>C	non_coding_transcript_exon_variant	0.56	capreomycin	Uncertain significance
rrl	1476153	n.2496T>C	non_coding_transcript_exon_variant	0.56	linezolid	Uncertain significance
rrl	1476164	n.2507A>G	non_coding_transcript_exon_variant	0.61	capreomycin	Uncertain significance
rrl	1476164	n.2507A>G	non_coding_transcript_exon_variant	0.61	linezolid	Uncertain significance
rrl	1476165	n.2508T>G	non_coding_transcript_exon_variant	0.65	capreomycin	Not assoc w R
rrl	1476165	n.2508T>G	non_coding_transcript_exon_variant	0.65	linezolid	Uncertain significance
rrl	1476194	n.2537A>G	non_coding_transcript_exon_variant	0.63	capreomycin	Not assoc w R
rrl	1476194	n.2537A>G	non_coding_transcript_exon_variant	0.63	linezolid	Uncertain significance
rrl	1476200	n.2543A>T	non_coding_transcript_exon_variant	0.62	capreomycin	Not assoc w R
rrl	1476200	n.2543A>T	non_coding_transcript_exon_variant	0.62	linezolid	Uncertain significance
rrl	1476201	n.2544C>T	non_coding_transcript_exon_variant	0.62	capreomycin	Not assoc w R
rrl	1476201	n.2544C>T	non_coding_transcript_exon_variant	0.62	linezolid	Uncertain significance
rrl	1476204	n.2547C>T	non_coding_transcript_exon_variant	0.62	capreomycin
rrl	1476204	n.2547C>T	non_coding_transcript_exon_variant	0.62	linezolid
rrl	1476215	n.2558C>T	non_coding_transcript_exon_variant	0.69	capreomycin	Uncertain significance
rrl	1476215	n.2558C>T	non_coding_transcript_exon_variant	0.69	linezolid	Uncertain significance
rrl	1476224	n.2567A>G	non_coding_transcript_exon_variant	0.69	capreomycin	Uncertain significance
rrl	1476224	n.2567A>G	non_coding_transcript_exon_variant	0.69	linezolid	Uncertain significance
rrl	1476235	n.2578A>G	non_coding_transcript_exon_variant	0.68	capreomycin
rrl	1476235	n.2578A>G	non_coding_transcript_exon_variant	0.68	linezolid
rrl	1476245	n.2588C>T	non_coding_transcript_exon_variant	0.64	capreomycin	Uncertain significance
rrl	1476245	n.2588C>T	non_coding_transcript_exon_variant	0.64	linezolid	Uncertain significance
rrl	1476252	n.2595T>G	non_coding_transcript_exon_variant	0.64	capreomycin	Uncertain significance
rrl	1476252	n.2595T>G	non_coding_transcript_exon_variant	0.64	linezolid	Uncertain significance
rrl	1476256	n.2599A>G	non_coding_transcript_exon_variant	0.63	capreomycin	Uncertain significance
rrl	1476256	n.2599A>G	non_coding_transcript_exon_variant	0.63	linezolid	Uncertain significance
rrl	1476260	n.2603A>G	non_coding_transcript_exon_variant	0.63	capreomycin	Not assoc w R
rrl	1476260	n.2603A>G	non_coding_transcript_exon_variant	0.63	linezolid	Uncertain significance
rrl	1476281	n.2624T>C	non_coding_transcript_exon_variant	0.55	capreomycin	Uncertain significance
rrl	1476281	n.2624T>C	non_coding_transcript_exon_variant	0.55	linezolid	Uncertain significance
rrl	1476359	n.2702C>G	non_coding_transcript_exon_variant	0.65	capreomycin	Uncertain significance
rrl	1476359	n.2702C>G	non_coding_transcript_exon_variant	0.65	linezolid	Uncertain significance
rrl	1476363	n.2706A>G	non_coding_transcript_exon_variant	0.65	capreomycin
rrl	1476363	n.2706A>G	non_coding_transcript_exon_variant	0.65	linezolid
rrl	1476366	n.2709A>C	non_coding_transcript_exon_variant	0.65	capreomycin
rrl	1476366	n.2709A>C	non_coding_transcript_exon_variant	0.65	linezolid
rrl	1476368	n.2711T>C	non_coding_transcript_exon_variant	0.66	capreomycin	Uncertain significance
rrl	1476368	n.2711T>C	non_coding_transcript_exon_variant	0.66	linezolid
rrl	1476369	n.2712C>T	non_coding_transcript_exon_variant	0.66	capreomycin	Uncertain significance
rrl	1476369	n.2712C>T	non_coding_transcript_exon_variant	0.66	linezolid	Uncertain significance
rrl	1476374	n.2717T>G	non_coding_transcript_exon_variant	0.7	capreomycin
rrl	1476374	n.2717T>G	non_coding_transcript_exon_variant	0.7	linezolid
rrl	1476381	n.2724G>C	non_coding_transcript_exon_variant	0.7	capreomycin	Uncertain significance
rrl	1476381	n.2724G>C	non_coding_transcript_exon_variant	0.7	linezolid	Uncertain significance
rrl	1476428	n.2771C>T	non_coding_transcript_exon_variant	0.8	capreomycin	Not assoc w R
rrl	1476428	n.2771C>T	non_coding_transcript_exon_variant	0.8	linezolid	Uncertain significance
rrl	1476429	n.2772A>C	non_coding_transcript_exon_variant	0.8	capreomycin	Uncertain significance
rrl	1476429	n.2772A>C	non_coding_transcript_exon_variant	0.8	linezolid	Uncertain significance
rrl	1476481	n.2824T>C	non_coding_transcript_exon_variant	0.72	capreomycin	Not assoc w R
rrl	1476481	n.2824T>C	non_coding_transcript_exon_variant	0.72	linezolid	Uncertain significance
rrl	1476506	n.2849T>C	non_coding_transcript_exon_variant	0.46	capreomycin	Not assoc w R
rrl	1476506	n.2849T>C	non_coding_transcript_exon_variant	0.46	linezolid	Uncertain significance
rrl	1476515	n.2858C>T	non_coding_transcript_exon_variant	0.24	capreomycin	Uncertain significance
rrl	1476515	n.2858C>T	non_coding_transcript_exon_variant	0.24	linezolid
rpsA	1833952	c.411C>A	synonymous_variant	0.26	pyrazinamide
rpsA	1833955	c.414G>T	synonymous_variant	0.26	pyrazinamide
rpsA	1833958	c.417C>T	synonymous_variant	0.26	pyrazinamide
rpsA	1833959	p.Leu140Val	missense_variant	0.27	pyrazinamide
rpsA	1833970	c.429G>C	synonymous_variant	0.37	pyrazinamide
rpsA	1833976	c.435C>T	synonymous_variant	0.39	pyrazinamide
rpsA	1833979	c.438T>C	synonymous_variant	0.39	pyrazinamide
rpsA	1833985	c.444G>T	synonymous_variant	0.42	pyrazinamide
rpsA	1833994	c.453G>C	synonymous_variant	0.45	pyrazinamide
rpsA	1833997	c.456G>T	synonymous_variant	0.42	pyrazinamide
rpsA	1834000	c.459G>T	synonymous_variant	0.45	pyrazinamide
rpsA	1834012	c.471G>A	synonymous_variant	0.42	pyrazinamide
rpsA	1834015	c.474G>C	synonymous_variant	0.43	pyrazinamide
rpsA	1834018	c.477C>T	synonymous_variant	0.44	pyrazinamide
rpsA	1834024	c.483G>C	synonymous_variant	0.41	pyrazinamide
rpsA	1834034	c.493_495delATCinsGG	frameshift_variant&missense_variant	0.37	pyrazinamide	Uncertain significance
rpsA	1834039	c.498C>T	synonymous_variant	0.37	pyrazinamide
rpsA	1834040	p.Lys167Gln	missense_variant	0.36	pyrazinamide
rpsA	1834069	c.528G>C	synonymous_variant	0.37	pyrazinamide
rpsA	1834090	c.549G>T	synonymous_variant	0.24	pyrazinamide
rpsA	1834099	c.558C>G	synonymous_variant	0.22	pyrazinamide
rpsA	1834105	c.564C>T	synonymous_variant	0.2	pyrazinamide
rpsA	1834108	c.567C>G	synonymous_variant	0.21	pyrazinamide
tlyA	1917972	c.33A>G	synonymous_variant	1.0	capreomycin	Not assoc w R
PPE35	2168728	p.Gly629Arg	missense_variant	1.0	pyrazinamide	Uncertain significance
Rv1979c	2223293	c.-129A>G	upstream_gene_variant	1.0	clofazimine	Not assoc w R
Rv1979c	2223293	c.-129A>G	upstream_gene_variant	1.0	bedaquiline	Not assoc w R - Interim
Rv3083	3448507	c.5_*1408del	frameshift_variant&stop_lost&splice_region_variant	1.0	ethionamide	Uncertain significance
embC	4242643	c.2781C>T	synonymous_variant	1.0	ethambutol	Not assoc w R
whiB6	4338595	c.-75delG	upstream_gene_variant	1.0	capreomycin	Not assoc w R
					amikacin	Not assoc w R
					kanamycin	Not assoc w R

Drug	Resistance	Supporting mutations	WHO confidence	Comment
rifampicin
isoniazid
ethambutol
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin	rrs	n.1402C>A	Uncertain significance	Mutation from literature
amikacin	rrs	n.1484G>T	Assoc w R
capreomycin	rrs	n.1402C>A	Uncertain significance	Mutation from literature
capreomycin	rrs	n.1484G>T	Assoc w R
kanamycin	rrs	n.1402C>A	Uncertain significance	Mutation from literature
kanamycin	rrs	n.1484G>T	Assoc w R
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid

TB-Profiler result