Run ID: ERR9786164
Sample name:
Date: 2024-10-05T08:50:14.376704
Number of reads: 683881
Percentage reads mapped: 55.85
Median coverage: 26.0
Strain: lineage4.1.1.3
Spoligotype:
Drug-resistance: RR-TB
Lineage | Family | RDs | Frequency |
---|---|---|---|
lineage4.1 | Euro-American | None | 1.0 |
lineage4.1.1.3 | Euro-American (X-type) | RD193 | 1.0 |
lineage4 | Euro-American | None | 1.0 |
lineage4.1.1 | Euro-American (X-type) | None | 1.0 |
Drug | Resistance | Supporting mutations | WHO confidence | Comment |
---|---|---|---|---|
rifampicin | rpoB | p.Ser441Ala | Assoc w R - Interim | Expert rule: Non-silent variants in RRDR of rpoB |
isoniazid | ||||
ethambutol | ||||
pyrazinamide | ||||
streptomycin | ||||
fluoroquinolones | ||||
moxifloxacin | ||||
ofloxacin | ||||
levofloxacin | ||||
ciprofloxacin | ||||
aminoglycosides | ||||
amikacin | rrs | n.1402C>A | Uncertain significance | Mutation from literature |
n.1484G>T | Assoc w R | |||
capreomycin | rrs | n.1402C>A | Uncertain significance | Mutation from literature |
n.1484G>T | Assoc w R | |||
kanamycin | rrs | n.1402C>A | Uncertain significance | Mutation from literature |
n.1484G>T | Assoc w R | |||
cycloserine | ||||
ethionamide | ||||
clofazimine | ||||
para-aminosalicylic_acid | ||||
delamanid | ||||
bedaquiline | ||||
linezolid |
Gene | Chromosome position | Mutation | Type | Estimated fraction | Drugs | Confidence | Comment |
---|---|---|---|---|---|---|---|
rpoB | 761127 | p.Ser441Ala | missense_variant | 0.42 | rifampicin | Assoc w R - Interim | Expert rule: Non-silent variants in RRDR of rpoB |
rrs | 1473247 | n.1402C>A | non_coding_transcript_exon_variant | 0.5 | amikacin | Uncertain significance | Mutation from literature |
capreomycin | Uncertain significance | Mutation from literature | |||||
kanamycin | Uncertain significance | Mutation from literature | |||||
rrs | 1473329 | n.1484G>T | non_coding_transcript_exon_variant | 0.27 | amikacin | Assoc w R | |
capreomycin | Assoc w R | ||||||
kanamycin | Assoc w R |
Gene | Chromosome position | Mutation | Type | Estimated fraction | Drugs | Confidence |
---|---|---|---|---|---|---|
gyrA | 7362 | p.Glu21Gln | missense_variant | 1.0 | levofloxacin | Not assoc w R |
moxifloxacin | Not assoc w R | |||||
gyrA | 7585 | p.Ser95Thr | missense_variant | 1.0 | levofloxacin | Not assoc w R |
moxifloxacin | Not assoc w R | |||||
gyrA | 9304 | p.Gly668Asp | missense_variant | 1.0 | levofloxacin | Not assoc w R |
moxifloxacin | Not assoc w R | |||||
Rv0565c | 657269 | p.Ser68Pro | missense_variant | 1.0 | ethionamide | Uncertain significance |
rpoB | 760991 | c.1185G>C | synonymous_variant | 0.3 | rifampicin | |
rpoB | 760997 | c.1191G>C | synonymous_variant | 0.34 | rifampicin | Not assoc w R - Interim |
rpoB | 761006 | c.1200C>G | synonymous_variant | 0.39 | rifampicin | Not assoc w R - Interim |
rpoB | 761013 | p.Val403Ile | missense_variant | 0.42 | rifampicin | |
rpoB | 761027 | c.1221A>G | synonymous_variant | 0.45 | rifampicin | Not assoc w R - Interim |
rpoB | 761036 | c.1230G>C | synonymous_variant | 0.47 | rifampicin | Not assoc w R - Interim |
rpoB | 761037 | c.1231T>C | synonymous_variant | 0.48 | rifampicin | Not assoc w R - Interim |
rpoB | 761046 | p.Ile414Val | missense_variant | 0.48 | rifampicin | |
rpoB | 761051 | c.1245G>C | synonymous_variant | 0.52 | rifampicin | Not assoc w R - Interim |
rpoB | 761054 | c.1248G>C | synonymous_variant | 0.52 | rifampicin | Not assoc w R - Interim |
rpoB | 761057 | c.1251G>C | synonymous_variant | 0.52 | rifampicin | Not assoc w R - Interim |
rpoB | 761087 | c.1281C>G | synonymous_variant | 0.52 | rifampicin | |
rpoB | 761088 | c.1282_1284delAGCinsTCG | synonymous_variant | 0.52 | rifampicin | |
rpoB | 761097 | c.1291_1293delAGCinsTCG | synonymous_variant | 0.48 | rifampicin | |
rpoB | 761102 | c.1296A>G | synonymous_variant | 0.45 | rifampicin | |
rpoB | 761126 | c.1320G>C | synonymous_variant | 0.42 | rifampicin | |
rpoB | 761132 | c.1326G>T | synonymous_variant | 0.42 | rifampicin | Not assoc w R - Interim |
rpoB | 761133 | c.1327T>C | synonymous_variant | 0.44 | rifampicin | Not assoc w R - Interim |
rpoB | 761150 | c.1344A>C | synonymous_variant | 0.41 | rifampicin | Not assoc w R - Interim |
rpoB | 761162 | c.1356G>C | synonymous_variant | 0.34 | rifampicin | |
rpoB | 761165 | c.1359G>C | synonymous_variant | 0.34 | rifampicin | Not assoc w R - Interim |
rpoB | 761171 | c.1365C>T | synonymous_variant | 0.34 | rifampicin | Not assoc w R - Interim |
rpoB | 761175 | c.1371_1372delGT | frameshift_variant | 0.32 | rifampicin | |
rpoB | 761180 | c.1374_1375insGC | frameshift_variant | 0.33 | rifampicin | |
rpoB | 761189 | c.1383T>C | synonymous_variant | 0.35 | rifampicin | Not assoc w R - Interim |
rpoB | 761195 | c.1389G>C | synonymous_variant | 0.35 | rifampicin | Not assoc w R - Interim |
rpoB | 761196 | p.Leu464Val | missense_variant | 0.35 | rifampicin | |
rpoB | 761207 | c.1401C>T | synonymous_variant | 0.35 | rifampicin | |
rpoB | 761213 | c.1407G>C | synonymous_variant | 0.33 | rifampicin | |
rpoB | 762929 | c.3123G>C | synonymous_variant | 0.23 | rifampicin | Not assoc w R - Interim |
rpoC | 762932 | c.-438G>C | upstream_gene_variant | 0.23 | rifampicin | |
rpoC | 762947 | c.-423C>G | upstream_gene_variant | 0.26 | rifampicin | |
rpoB | 762962 | c.3156C>T | synonymous_variant | 0.3 | rifampicin | Not assoc w R - Interim |
rpoC | 762980 | c.-390T>C | upstream_gene_variant | 0.32 | rifampicin | |
rpoC | 762989 | c.-381G>C | upstream_gene_variant | 0.31 | rifampicin | |
rpoB | 762995 | c.3189G>C | synonymous_variant | 0.3 | rifampicin | Not assoc w R - Interim |
rpoB | 763005 | p.Cys1067Val | missense_variant | 0.3 | rifampicin | |
rpoC | 763013 | c.-357C>G | upstream_gene_variant | 0.29 | rifampicin | |
rpoB | 763014 | p.Met1070Leu | missense_variant | 0.3 | rifampicin | |
rpoB | 763017 | p.Gln1071Glu | missense_variant | 0.29 | rifampicin | |
rpoB | 763031 | c.3225T>C | synonymous_variant | 0.25 | rifampicin | Not assoc w R |
rpoB | 763034 | c.3228C>G | synonymous_variant | 0.24 | rifampicin | Not assoc w R - Interim |
rpoB | 763038 | p.Thr1078Ala | missense_variant | 0.25 | rifampicin | |
rpoC | 763052 | c.-318G>C | upstream_gene_variant | 0.28 | rifampicin | |
rpoB | 763053 | c.3247T>C | synonymous_variant | 0.28 | rifampicin | Not assoc w R - Interim |
rpoC | 763058 | c.-312C>G | upstream_gene_variant | 0.29 | rifampicin | |
rpoB | 763070 | c.3264T>C | synonymous_variant | 0.31 | rifampicin | Not assoc w R - Interim |
rpoB | 763075 | p.Thr1090Ile | missense_variant | 0.31 | rifampicin | |
rpoB | 763094 | c.3288G>C | synonymous_variant | 0.29 | rifampicin | Not assoc w R - Interim |
rpoB | 763115 | c.3309T>C | synonymous_variant | 0.25 | rifampicin | Not assoc w R - Interim |
rpoB | 763126 | p.Pro1107Gln | missense_variant | 0.24 | rifampicin | |
rpoC | 763570 | c.201G>C | synonymous_variant | 0.19 | rifampicin | Not assoc w R - Interim |
rpoC | 763573 | c.204G>C | synonymous_variant | 0.19 | rifampicin | Not assoc w R - Interim |
rpoC | 763589 | p.Ile74Val | missense_variant | 0.22 | rifampicin | |
rpoC | 763642 | c.273G>C | synonymous_variant | 0.21 | rifampicin | Not assoc w R - Interim |
rpoC | 763660 | c.291T>C | synonymous_variant | 0.21 | rifampicin | Not assoc w R - Interim |
rpoC | 763666 | c.297G>C | synonymous_variant | 0.21 | rifampicin | Not assoc w R - Interim |
rpoC | 764353 | c.984G>C | synonymous_variant | 0.19 | rifampicin | |
rpoC | 764365 | c.996C>T | synonymous_variant | 0.21 | rifampicin | Not assoc w R - Interim |
rpoC | 764371 | c.1002G>C | synonymous_variant | 0.21 | rifampicin | Not assoc w R - Interim |
rpoC | 764380 | c.1011G>C | synonymous_variant | 0.21 | rifampicin | Not assoc w R - Interim |
rpoC | 764381 | c.1012_1013delTCinsAG | synonymous_variant | 0.21 | rifampicin | |
rpoC | 764387 | c.1018T>C | synonymous_variant | 0.24 | rifampicin | Not assoc w R - Interim |
rpoC | 764405 | c.1036_1038delAGGinsCGC | synonymous_variant | 0.33 | rifampicin | Not assoc w R - Interim |
rpoC | 764428 | c.1059G>C | synonymous_variant | 0.35 | rifampicin | Not assoc w R - Interim |
rpoC | 764431 | c.1062G>C | synonymous_variant | 0.35 | rifampicin | Not assoc w R - Interim |
rpoC | 764432 | p.Lys355Arg | missense_variant | 0.35 | rifampicin | |
rpoC | 764435 | c.1066_1068delAGGinsCGC | synonymous_variant | 0.36 | rifampicin | |
rpoC | 764446 | c.1077T>C | synonymous_variant | 0.37 | rifampicin | |
rpoC | 764449 | c.1080G>C | synonymous_variant | 0.37 | rifampicin | |
rpoC | 764455 | c.1086G>C | synonymous_variant | 0.38 | rifampicin | |
rpoC | 764458 | c.1089G>C | synonymous_variant | 0.39 | rifampicin | Not assoc w R - Interim |
rpoC | 764461 | c.1092A>G | synonymous_variant | 0.4 | rifampicin | Not assoc w R - Interim |
rpoC | 764470 | c.1101C>G | synonymous_variant | 0.46 | rifampicin | |
rpoC | 764497 | c.1128A>G | synonymous_variant | 0.5 | rifampicin | Not assoc w R - Interim |
rpoC | 764498 | p.Ser377Ala | missense_variant | 0.51 | rifampicin | |
rpoC | 764503 | c.1134G>C | synonymous_variant | 0.53 | rifampicin | |
rpoC | 764509 | c.1140G>C | synonymous_variant | 0.53 | rifampicin | Not assoc w R - Interim |
rpoC | 764521 | c.1152T>C | synonymous_variant | 0.53 | rifampicin | Not assoc w R - Interim |
rpoC | 764533 | c.1164C>T | synonymous_variant | 0.52 | rifampicin | |
rpoC | 764536 | c.1167G>T | synonymous_variant | 0.54 | rifampicin | Not assoc w R - Interim |
rpoC | 764548 | c.1179G>T | synonymous_variant | 0.52 | rifampicin | Not assoc w R - Interim |
rpoC | 764549 | p.Pro394Thr | missense_variant | 0.52 | rifampicin | |
rpoC | 764561 | p.Pro398Ala | missense_variant | 0.55 | rifampicin | |
rpoC | 764566 | c.1197C>G | synonymous_variant | 0.56 | rifampicin | Not assoc w R - Interim |
rpoC | 764575 | c.1206T>G | synonymous_variant | 0.52 | rifampicin | Not assoc w R - Interim |
rpoC | 764581 | c.1212T>C | synonymous_variant | 0.47 | rifampicin | |
rpoC | 764582 | p.Leu405Met | missense_variant | 0.47 | rifampicin | |
rpoC | 764611 | c.1242G>C | synonymous_variant | 0.45 | rifampicin | |
rpoC | 764632 | c.1263T>C | synonymous_variant | 0.4 | rifampicin | Not assoc w R - Interim |
rpoC | 764635 | c.1266C>G | synonymous_variant | 0.39 | rifampicin | |
rpoC | 764650 | c.1281G>T | synonymous_variant | 0.25 | rifampicin | Not assoc w R - Interim |
rpoC | 764660 | p.Val431Ile | missense_variant | 0.25 | rifampicin | |
rpoC | 764677 | c.1308C>G | synonymous_variant | 0.25 | rifampicin | Not assoc w R - Interim |
rpoC | 764683 | c.1314G>C | synonymous_variant | 0.23 | rifampicin | |
rpoC | 764692 | c.1323C>T | synonymous_variant | 0.23 | rifampicin | Not assoc w R - Interim |
rpoC | 764705 | p.Leu446Ala | missense_variant | 0.16 | rifampicin | |
rpoC | 764716 | c.1347G>C | synonymous_variant | 0.13 | rifampicin | Not assoc w R - Interim |
rpoC | 765150 | p.Gly594Glu | missense_variant | 1.0 | rifampicin | Not assoc w R |
mmpL5 | 775639 | p.Ile948Val | missense_variant | 1.0 | bedaquiline | Not assoc w R - Interim |
clofazimine | Not assoc w R | |||||
rpsL | 781395 | c.-165T>C | upstream_gene_variant | 1.0 | streptomycin | Not assoc w R |
rplC | 800219 | c.-590T>C | upstream_gene_variant | 1.0 | linezolid | |
rrs | 1471659 | n.-187C>T | upstream_gene_variant | 1.0 | kanamycin | |
capreomycin | ||||||
streptomycin | ||||||
amikacin | ||||||
rrs | 1472102 | n.257G>A | non_coding_transcript_exon_variant | 0.25 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | ||||||
amikacin | Uncertain significance | |||||
rrs | 1472106 | n.261G>A | non_coding_transcript_exon_variant | 0.29 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | Uncertain significance | |||||
amikacin | Not assoc w R | |||||
rrs | 1472112 | n.267C>T | non_coding_transcript_exon_variant | 0.3 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472113 | n.268T>C | non_coding_transcript_exon_variant | 0.3 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472123 | n.278A>T | non_coding_transcript_exon_variant | 0.24 | kanamycin | |
capreomycin | ||||||
streptomycin | ||||||
amikacin | ||||||
rrs | 1472150 | n.305T>A | non_coding_transcript_exon_variant | 0.26 | kanamycin | Uncertain significance |
capreomycin | Not assoc w R | |||||
streptomycin | Uncertain significance | |||||
amikacin | Not assoc w R | |||||
rrs | 1472172 | n.327T>C | non_coding_transcript_exon_variant | 0.28 | kanamycin | Uncertain significance |
capreomycin | Not assoc w R | |||||
streptomycin | Uncertain significance | |||||
amikacin | Not assoc w R | |||||
rrs | 1472240 | n.395G>A | non_coding_transcript_exon_variant | 0.35 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472251 | n.406G>A | non_coding_transcript_exon_variant | 0.33 | kanamycin | Uncertain significance |
capreomycin | Not assoc w R | |||||
streptomycin | Uncertain significance | |||||
amikacin | Not assoc w R | |||||
rrs | 1472256 | n.411T>C | non_coding_transcript_exon_variant | 0.33 | kanamycin | |
capreomycin | ||||||
streptomycin | ||||||
amikacin | ||||||
rrs | 1472382 | n.537G>A | non_coding_transcript_exon_variant | 0.29 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | Uncertain significance | |||||
amikacin | Not assoc w R | |||||
rrs | 1472494 | n.649A>G | non_coding_transcript_exon_variant | 0.18 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472496 | n.651T>G | non_coding_transcript_exon_variant | 0.18 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472498 | n.653C>T | non_coding_transcript_exon_variant | 0.2 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472507 | n.662C>T | non_coding_transcript_exon_variant | 0.25 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | ||||||
amikacin | Uncertain significance | |||||
rrs | 1472558 | n.713G>A | non_coding_transcript_exon_variant | 0.3 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472569 | n.724G>A | non_coding_transcript_exon_variant | 0.3 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472571 | n.726G>A | non_coding_transcript_exon_variant | 0.3 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472581 | n.736A>C | non_coding_transcript_exon_variant | 0.34 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472606 | n.761C>G | non_coding_transcript_exon_variant | 0.39 | kanamycin | |
capreomycin | ||||||
streptomycin | ||||||
amikacin | ||||||
rrs | 1472616 | n.771G>A | non_coding_transcript_exon_variant | 0.4 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472623 | n.778A>C | non_coding_transcript_exon_variant | 0.38 | kanamycin | |
capreomycin | ||||||
streptomycin | ||||||
amikacin | ||||||
rrs | 1472645 | n.800G>C | non_coding_transcript_exon_variant | 0.42 | kanamycin | |
capreomycin | ||||||
streptomycin | ||||||
amikacin | ||||||
rrs | 1472655 | n.810G>T | non_coding_transcript_exon_variant | 0.35 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472660 | n.815T>A | non_coding_transcript_exon_variant | 0.34 | kanamycin | |
capreomycin | ||||||
streptomycin | ||||||
amikacin | ||||||
rrs | 1472666 | n.821G>T | non_coding_transcript_exon_variant | 0.35 | kanamycin | |
capreomycin | ||||||
streptomycin | ||||||
amikacin | ||||||
rrs | 1472673 | n.828T>G | non_coding_transcript_exon_variant | 0.32 | kanamycin | |
capreomycin | ||||||
streptomycin | ||||||
amikacin | ||||||
rrs | 1472675 | n.830T>C | non_coding_transcript_exon_variant | 0.32 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | ||||||
amikacin | Uncertain significance | |||||
rrs | 1472677 | n.832C>A | non_coding_transcript_exon_variant | 0.3 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | ||||||
amikacin | Uncertain significance | |||||
rrs | 1472682 | n.837T>A | non_coding_transcript_exon_variant | 0.3 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472683 | n.838T>C | non_coding_transcript_exon_variant | 0.3 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472686 | n.841G>A | non_coding_transcript_exon_variant | 0.3 | kanamycin | |
capreomycin | ||||||
streptomycin | ||||||
amikacin | ||||||
rrs | 1472687 | n.842A>T | non_coding_transcript_exon_variant | 0.3 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | ||||||
amikacin | Uncertain significance | |||||
rrs | 1472694 | n.849C>A | non_coding_transcript_exon_variant | 0.31 | kanamycin | |
capreomycin | ||||||
streptomycin | ||||||
amikacin | ||||||
rrs | 1472697 | n.852T>C | non_coding_transcript_exon_variant | 0.3 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | Uncertain significance | |||||
amikacin | Not assoc w R | |||||
rrs | 1472714 | n.869A>T | non_coding_transcript_exon_variant | 0.31 | kanamycin | |
capreomycin | ||||||
streptomycin | ||||||
amikacin | ||||||
rrs | 1472952 | n.1107T>C | non_coding_transcript_exon_variant | 0.23 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472955 | n.1110C>T | non_coding_transcript_exon_variant | 0.23 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472956 | n.1111T>C | non_coding_transcript_exon_variant | 0.23 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472957 | n.1112C>T | non_coding_transcript_exon_variant | 0.2 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472982 | n.1137G>A | non_coding_transcript_exon_variant | 0.29 | kanamycin | |
capreomycin | ||||||
streptomycin | ||||||
amikacin | ||||||
rrs | 1472987 | n.1142G>A | non_coding_transcript_exon_variant | 0.29 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472990 | n.1145A>G | non_coding_transcript_exon_variant | 0.31 | kanamycin | Not assoc w R |
capreomycin | Not assoc w R | |||||
streptomycin | Uncertain significance | |||||
amikacin | Not assoc w R | |||||
rrs | 1472993 | n.1148G>T | non_coding_transcript_exon_variant | 0.34 | kanamycin | |
capreomycin | ||||||
streptomycin | ||||||
amikacin | ||||||
rrs | 1473035 | n.1190G>A | non_coding_transcript_exon_variant | 0.44 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | Uncertain significance | |||||
amikacin | Not assoc w R | |||||
rrs | 1473055 | n.1210C>T | non_coding_transcript_exon_variant | 0.56 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1473056 | n.1211A>T | non_coding_transcript_exon_variant | 0.54 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | Uncertain significance | |||||
amikacin | Not assoc w R | |||||
rrs | 1473066 | n.1221A>G | non_coding_transcript_exon_variant | 0.48 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1473097 | n.1252G>A | non_coding_transcript_exon_variant | 0.51 | kanamycin | |
capreomycin | ||||||
streptomycin | ||||||
amikacin | ||||||
rrs | 1473100 | n.1255G>A | non_coding_transcript_exon_variant | 0.51 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1473104 | n.1259C>T | non_coding_transcript_exon_variant | 0.51 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1473105 | n.1260G>A | non_coding_transcript_exon_variant | 0.51 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | ||||||
amikacin | Uncertain significance | |||||
rrs | 1473110 | n.1265T>G | non_coding_transcript_exon_variant | 0.52 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1473111 | n.1266A>G | non_coding_transcript_exon_variant | 0.53 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1473121 | n.1276T>C | non_coding_transcript_exon_variant | 0.55 | kanamycin | Uncertain significance |
capreomycin | Not assoc w R | |||||
streptomycin | Uncertain significance | |||||
amikacin | Not assoc w R | |||||
rrs | 1473122 | n.1277T>A | non_coding_transcript_exon_variant | 0.55 | kanamycin | Uncertain significance |
capreomycin | Not assoc w R | |||||
streptomycin | Uncertain significance | |||||
amikacin | Not assoc w R | |||||
rrs | 1473134 | n.1289T>C | non_coding_transcript_exon_variant | 0.54 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | ||||||
amikacin | Uncertain significance | |||||
rrs | 1473145 | n.1300C>T | non_coding_transcript_exon_variant | 0.57 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1473147 | n.1302G>A | non_coding_transcript_exon_variant | 0.57 | kanamycin | Uncertain significance |
capreomycin | ||||||
streptomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1473164 | n.1319C>T | non_coding_transcript_exon_variant | 0.59 | kanamycin | |
capreomycin | ||||||
streptomycin | Uncertain significance | |||||
amikacin | ||||||
rrs | 1473166 | n.1321G>A | non_coding_transcript_exon_variant | 0.6 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1473226 | n.1381C>T | non_coding_transcript_exon_variant | 0.53 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1473269 | n.1424C>T | non_coding_transcript_exon_variant | 0.42 | kanamycin | |
capreomycin | ||||||
streptomycin | ||||||
amikacin | ||||||
rrs | 1473276 | n.1431A>G | non_coding_transcript_exon_variant | 0.41 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1473283 | n.1438T>C | non_coding_transcript_exon_variant | 0.4 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | ||||||
amikacin | Uncertain significance | |||||
rrs | 1473290 | n.1445C>T | non_coding_transcript_exon_variant | 0.33 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | ||||||
amikacin | Uncertain significance | |||||
rrs | 1473291 | n.1446_1447insT | non_coding_transcript_exon_variant | 0.36 | kanamycin | |
capreomycin | ||||||
streptomycin | ||||||
amikacin | ||||||
rrs | 1473301 | n.1456T>C | non_coding_transcript_exon_variant | 0.32 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrl | 1474466 | n.809G>A | non_coding_transcript_exon_variant | 0.19 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474476 | n.819C>T | non_coding_transcript_exon_variant | 0.2 | capreomycin | |
linezolid | ||||||
rrl | 1474488 | n.831G>C | non_coding_transcript_exon_variant | 0.21 | capreomycin | |
linezolid | ||||||
rrl | 1474496 | n.839C>A | non_coding_transcript_exon_variant | 0.21 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474497 | n.840G>C | non_coding_transcript_exon_variant | 0.26 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474506 | n.849C>G | non_coding_transcript_exon_variant | 0.29 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474507 | n.850G>T | non_coding_transcript_exon_variant | 0.29 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474516 | n.859C>G | non_coding_transcript_exon_variant | 0.33 | capreomycin | |
linezolid | ||||||
rrl | 1474537 | n.880G>A | non_coding_transcript_exon_variant | 0.35 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474558 | n.901G>A | non_coding_transcript_exon_variant | 0.37 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1474583 | n.926C>T | non_coding_transcript_exon_variant | 0.29 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474601 | n.944C>T | non_coding_transcript_exon_variant | 0.29 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474676 | n.1019T>A | non_coding_transcript_exon_variant | 0.32 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474709 | n.1053_1056delTGGT | non_coding_transcript_exon_variant | 0.23 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474717 | n.1060_1061insGTGAG | non_coding_transcript_exon_variant | 0.24 | capreomycin | |
linezolid | ||||||
rrl | 1474722 | n.1065T>C | non_coding_transcript_exon_variant | 0.24 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1474723 | n.1066G>A | non_coding_transcript_exon_variant | 0.25 | capreomycin | |
linezolid | ||||||
rrl | 1474734 | n.1077G>T | non_coding_transcript_exon_variant | 0.28 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474736 | n.1079C>T | non_coding_transcript_exon_variant | 0.28 | capreomycin | |
linezolid | ||||||
rrl | 1474749 | n.1092C>T | non_coding_transcript_exon_variant | 0.28 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474751 | n.1094G>A | non_coding_transcript_exon_variant | 0.28 | capreomycin | |
linezolid | ||||||
rrl | 1474753 | n.1097delC | non_coding_transcript_exon_variant | 0.28 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474760 | n.1103A>G | non_coding_transcript_exon_variant | 0.27 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474770 | n.1113G>A | non_coding_transcript_exon_variant | 0.26 | capreomycin | |
linezolid | ||||||
rrl | 1474777 | n.1120T>C | non_coding_transcript_exon_variant | 0.27 | capreomycin | Not assoc w R |
linezolid | Uncertain significance | |||||
rrl | 1474779 | n.1122G>A | non_coding_transcript_exon_variant | 0.29 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474782 | n.1125G>A | non_coding_transcript_exon_variant | 0.26 | capreomycin | Not assoc w R |
linezolid | Uncertain significance | |||||
rrl | 1474783 | n.1126G>A | non_coding_transcript_exon_variant | 0.26 | capreomycin | |
linezolid | ||||||
rrl | 1474790 | n.1133C>T | non_coding_transcript_exon_variant | 0.28 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474794 | n.1137C>A | non_coding_transcript_exon_variant | 0.29 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474800 | n.1143T>C | non_coding_transcript_exon_variant | 0.3 | capreomycin | |
linezolid | ||||||
rrl | 1474823 | n.1166C>G | non_coding_transcript_exon_variant | 0.32 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474827 | n.1170C>T | non_coding_transcript_exon_variant | 0.32 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474830 | n.1173A>T | non_coding_transcript_exon_variant | 0.28 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474831 | n.1174A>C | non_coding_transcript_exon_variant | 0.28 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474832 | n.1175A>T | non_coding_transcript_exon_variant | 0.28 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474904 | n.1247G>C | non_coding_transcript_exon_variant | 0.35 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1475768 | n.2111_2112delGTinsC | non_coding_transcript_exon_variant | 0.21 | capreomycin | |
linezolid | ||||||
rrl | 1475775 | n.2118G>T | non_coding_transcript_exon_variant | 0.26 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1475881 | n.2224T>C | non_coding_transcript_exon_variant | 0.39 | capreomycin | |
linezolid | ||||||
rrl | 1475896 | n.2239A>G | non_coding_transcript_exon_variant | 0.35 | capreomycin | |
linezolid | ||||||
rrl | 1475897 | n.2240T>C | non_coding_transcript_exon_variant | 0.37 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1475898 | n.2241A>G | non_coding_transcript_exon_variant | 0.37 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1475899 | n.2242G>A | non_coding_transcript_exon_variant | 0.36 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1475943 | n.2286G>A | non_coding_transcript_exon_variant | 0.47 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1475952 | n.2295A>G | non_coding_transcript_exon_variant | 0.44 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1475963 | n.2306G>T | non_coding_transcript_exon_variant | 0.36 | capreomycin | |
linezolid | ||||||
rrl | 1475970 | n.2313C>T | non_coding_transcript_exon_variant | 0.35 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1475977 | n.2320A>G | non_coding_transcript_exon_variant | 0.33 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1475988 | n.2331A>G | non_coding_transcript_exon_variant | 0.31 | capreomycin | Not assoc w R |
linezolid | Uncertain significance | |||||
rrl | 1475997 | n.2340A>G | non_coding_transcript_exon_variant | 0.33 | capreomycin | |
linezolid | ||||||
rrl | 1475998 | n.2341C>T | non_coding_transcript_exon_variant | 0.32 | capreomycin | |
linezolid | Uncertain significance | |||||
rrl | 1476001 | n.2344T>C | non_coding_transcript_exon_variant | 0.35 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476030 | n.2373A>G | non_coding_transcript_exon_variant | 0.24 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1476160 | n.2503T>C | non_coding_transcript_exon_variant | 0.33 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476165 | n.2508T>A | non_coding_transcript_exon_variant | 0.33 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476200 | n.2543A>T | non_coding_transcript_exon_variant | 0.4 | capreomycin | Not assoc w R |
linezolid | Uncertain significance | |||||
rrl | 1476201 | n.2544C>T | non_coding_transcript_exon_variant | 0.4 | capreomycin | Not assoc w R |
linezolid | Uncertain significance | |||||
rrl | 1476224 | n.2567A>G | non_coding_transcript_exon_variant | 0.39 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476245 | n.2588C>T | non_coding_transcript_exon_variant | 0.37 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476252 | n.2595T>G | non_coding_transcript_exon_variant | 0.39 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476256 | n.2599A>G | non_coding_transcript_exon_variant | 0.39 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476260 | n.2603A>G | non_coding_transcript_exon_variant | 0.4 | capreomycin | Not assoc w R |
linezolid | Uncertain significance | |||||
rrl | 1476281 | n.2624T>C | non_coding_transcript_exon_variant | 0.44 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476295 | n.2638C>G | non_coding_transcript_exon_variant | 0.41 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476296 | n.2639C>T | non_coding_transcript_exon_variant | 0.41 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476297 | n.2640C>G | non_coding_transcript_exon_variant | 0.41 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476298 | n.2641C>G | non_coding_transcript_exon_variant | 0.41 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476300 | n.2643G>T | non_coding_transcript_exon_variant | 0.4 | capreomycin | |
linezolid | ||||||
rrl | 1476301 | n.2644A>T | non_coding_transcript_exon_variant | 0.41 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476309 | n.2652G>C | non_coding_transcript_exon_variant | 0.42 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476311 | n.2654G>C | non_coding_transcript_exon_variant | 0.42 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476337 | n.2680C>T | non_coding_transcript_exon_variant | 0.5 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476359 | n.2702C>G | non_coding_transcript_exon_variant | 0.47 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476381 | n.2724G>C | non_coding_transcript_exon_variant | 0.47 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476428 | n.2771C>T | non_coding_transcript_exon_variant | 0.38 | capreomycin | Not assoc w R |
linezolid | Uncertain significance | |||||
rrl | 1476466 | n.2809C>T | non_coding_transcript_exon_variant | 0.25 | capreomycin | Not assoc w R |
linezolid | Uncertain significance | |||||
rrl | 1476506 | n.2849T>C | non_coding_transcript_exon_variant | 0.2 | capreomycin | Not assoc w R |
linezolid | Uncertain significance | |||||
rpsA | 1833742 | c.201A>G | synonymous_variant | 0.24 | pyrazinamide | |
rpsA | 1833745 | c.204G>C | synonymous_variant | 0.24 | pyrazinamide | |
rpsA | 1833769 | c.228C>G | synonymous_variant | 0.22 | pyrazinamide | |
rpsA | 1833781 | c.240T>C | synonymous_variant | 0.24 | pyrazinamide | |
rpsA | 1833782 | p.Ser81Lys | missense_variant | 0.24 | pyrazinamide | |
rpsA | 1833790 | c.249T>C | synonymous_variant | 0.26 | pyrazinamide | |
rpsA | 1833808 | c.267G>C | synonymous_variant | 0.26 | pyrazinamide | |
rpsA | 1833811 | c.270G>C | synonymous_variant | 0.26 | pyrazinamide | |
rpsA | 1833815 | p.Thr92Gln | missense_variant | 0.26 | pyrazinamide | |
rpsA | 1833829 | c.288A>G | synonymous_variant | 0.29 | pyrazinamide | |
rpsA | 1833832 | c.291G>A | synonymous_variant | 0.29 | pyrazinamide | |
rpsA | 1833838 | c.297G>C | synonymous_variant | 0.32 | pyrazinamide | |
rpsA | 1833856 | c.315A>G | synonymous_variant | 0.38 | pyrazinamide | |
rpsA | 1833874 | c.333T>C | synonymous_variant | 0.35 | pyrazinamide | |
rpsA | 1833884 | p.Thr115Asp | missense_variant | 0.33 | pyrazinamide | |
rpsA | 1833887 | p.Ile116Val | missense_variant | 0.33 | pyrazinamide | |
rpsA | 1833893 | p.Ala118Lys | missense_variant | 0.33 | pyrazinamide | |
rpsA | 1833896 | p.Leu119Ile | missense_variant | 0.34 | pyrazinamide | |
rpsA | 1833907 | p.Lys122Asn | missense_variant | 0.29 | pyrazinamide | |
rpsA | 1833912 | p.Glu124Gly | missense_variant | 0.29 | pyrazinamide | |
rpsA | 1833915 | p.Ala125Val | missense_variant | 0.29 | pyrazinamide | Uncertain significance |
rpsA | 1833921 | p.Lys127Thr | missense_variant | 0.29 | pyrazinamide | |
rpsA | 1833928 | c.387G>C | synonymous_variant | 0.3 | pyrazinamide | |
rpsA | 1833955 | c.414G>C | synonymous_variant | 0.2 | pyrazinamide | |
rpsA | 1833959 | p.Leu140Val | missense_variant | 0.2 | pyrazinamide | |
rpsA | 1833970 | c.429G>C | synonymous_variant | 0.17 | pyrazinamide | |
rpsA | 1833979 | c.438T>G | synonymous_variant | 0.16 | pyrazinamide | |
rpsA | 1834423 | c.882G>T | synonymous_variant | 0.3 | pyrazinamide | |
rpsA | 1834427 | p.Ile296Val | missense_variant | 0.3 | pyrazinamide | Uncertain significance |
rpsA | 1834431 | p.Val297Ala | missense_variant | 0.28 | pyrazinamide | Uncertain significance |
tsnR | 1854300 | p.Leu232Pro | missense_variant | 1.0 | linezolid | Not assoc w R |
tlyA | 1917972 | c.33A>G | synonymous_variant | 1.0 | capreomycin | Not assoc w R |
Rv1979c | 2223293 | c.-129A>G | upstream_gene_variant | 1.0 | bedaquiline | Not assoc w R - Interim |
clofazimine | Not assoc w R | |||||
pepQ | 2860619 | c.-201C>T | upstream_gene_variant | 1.0 | bedaquiline | |
clofazimine | ||||||
ald | 3086788 | c.-32T>C | upstream_gene_variant | 1.0 | cycloserine | |
fbiD | 3339178 | p.Ala21Thr | missense_variant | 1.0 | pretomanid | |
delamanid | Uncertain significance | |||||
clofazimine | Uncertain significance | |||||
mtrB | 3625065 | p.Met517Leu | missense_variant | 1.0 | rifampicin | Not assoc w R |
bedaquiline | Uncertain significance | |||||
embC | 4239763 | c.-100C>T | upstream_gene_variant | 1.0 | ethambutol | Not assoc w R |
embC | 4242643 | c.2781C>T | synonymous_variant | 1.0 | ethambutol | Not assoc w R |
embC | 4242803 | p.Val981Leu | missense_variant | 1.0 | ethambutol | Not assoc w R |
embB | 4249408 | c.2895G>A | synonymous_variant | 1.0 | ethambutol | Not assoc w R |
whiB6 | 4338595 | c.-75delG | upstream_gene_variant | 1.0 | kanamycin | Not assoc w R |
capreomycin | Not assoc w R | |||||
amikacin | Not assoc w R | |||||
whiB6 | 4338732 | c.-211C>T | upstream_gene_variant | 1.0 | kanamycin | |
capreomycin | ||||||
amikacin |