TB-Profiler result

Run: ERR11081258
Summary

Run ID: ERR11081258

Sample name:

Date: 2024-10-05T06:38:22.841560

Number of reads: 1389884

Percentage reads mapped: 92.15

Median coverage: 64.0

Strain: lineage4.8

Spoligotype:

Drug-resistance: Other

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage4 Euro-American None 0.99
lineage4.8 Euro-American (mainly T) RD219 0.98
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol
pyrazinamide
streptomycin rrs n.462C>T Uncertain significance Mutation from literature
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
rrs 1472307 n.462C>T non_coding_transcript_exon_variant 0.35 streptomycin Uncertain significance Mutation from literature
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
dnaA 371 p.Pro124Leu missense_variant 1.0 isoniazid Not assoc w R
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
rpoB 760121 c.315T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760130 p.Asp108Glu missense_variant 0.16 rifampicin Uncertain significance
rpoB 760139 c.333A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760142 c.336C>G synonymous_variant 0.18 rifampicin
rpoB 760181 c.375T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760184 c.378A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760196 c.390C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760223 c.417T>C synonymous_variant 0.27 rifampicin
rpoB 760235 c.429T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 760283 c.477G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 760298 c.492G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 760307 c.501T>C synonymous_variant 0.28 rifampicin
rpoB 760310 c.504G>C synonymous_variant 0.28 rifampicin
rpoB 760328 c.522G>C synonymous_variant 0.25 rifampicin
rpoB 760331 c.525G>C synonymous_variant 0.24 rifampicin
rpoB 760340 c.534G>T synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 760361 c.555T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760370 c.564C>G synonymous_variant 0.23 rifampicin
rpoB 760376 p.Asp190Glu missense_variant 0.21 rifampicin Uncertain significance
rpoB 760380 p.Thr192Leu missense_variant 0.23 rifampicin
rpoB 760406 c.600G>C synonymous_variant 0.22 rifampicin
rpoB 760412 c.606C>G synonymous_variant 0.22 rifampicin
rpoB 760424 c.618C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760430 c.624T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760982 c.1176G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760985 c.1179G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760991 c.1185G>C synonymous_variant 0.18 rifampicin
rpoB 761006 c.1200C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761015 c.1209G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761021 c.1215G>C synonymous_variant 0.21 rifampicin
rpoB 761027 c.1221A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 761036 c.1230G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761037 c.1231T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 761057 c.1251G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761102 c.1296A>G synonymous_variant 0.27 rifampicin
rpoB 761129 c.1323G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 761132 c.1326G>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 761133 c.1327T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 761150 c.1344A>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 761153 c.1347G>C synonymous_variant 0.25 rifampicin
rpoB 761165 c.1359G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 761180 c.1374A>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 761189 c.1383T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 761195 c.1389G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761207 c.1401C>T synonymous_variant 0.22 rifampicin
rpoB 761213 c.1407G>C synonymous_variant 0.19 rifampicin
rpoB 761219 c.1413G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 761408 c.1602G>C synonymous_variant 0.17 rifampicin
rpoB 761414 c.1608A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 761423 c.1617T>C synonymous_variant 0.16 rifampicin
rpoB 761439 p.Asp545Asn missense_variant 0.14 rifampicin
rpoB 761444 c.1638T>C synonymous_variant 0.14 rifampicin
rpoB 761447 c.1641C>G synonymous_variant 0.14 rifampicin
rpoB 761452 p.Val549Asp missense_variant 0.14 rifampicin
rpoB 761457 p.Pro551Ser missense_variant 0.14 rifampicin
rpoB 761477 c.1671C>G synonymous_variant 0.17 rifampicin
rpoB 761492 c.1686G>C synonymous_variant 0.18 rifampicin
rpoB 761510 c.1704T>C synonymous_variant 0.17 rifampicin
rpoB 761537 c.1731C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761570 c.1764T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 761573 c.1767C>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 761579 c.1773G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 761588 c.1782C>T synonymous_variant 0.18 rifampicin
rpoB 761606 c.1800C>G synonymous_variant 0.18 rifampicin
rpoB 761612 c.1806G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 761615 c.1809A>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 761636 c.1830G>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 761639 c.1833G>A synonymous_variant 0.17 rifampicin
rpoB 761645 c.1839C>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 761648 c.1842T>C synonymous_variant 0.17 rifampicin
rpoB 761657 c.1851C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761675 c.1869G>C synonymous_variant 0.2 rifampicin
rpoB 761720 c.1914C>G synonymous_variant 0.19 rifampicin
rpoB 761723 c.1917_1919delAGAinsC frameshift_variant&missense_variant 0.18 rifampicin
rpoB 761732 c.1926C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761735 c.1929C>G synonymous_variant 0.22 rifampicin
rpoB 761747 c.1941G>C synonymous_variant 0.24 rifampicin
rpoB 761750 c.1944G>C synonymous_variant 0.24 rifampicin
rpoB 761765 c.1959T>C synonymous_variant 0.26 rifampicin
rpoB 761772 p.His656Ala missense_variant 0.25 rifampicin
rpoB 761778 p.Asn658Asp missense_variant 0.27 rifampicin
rpoB 761791 p.Arg662His missense_variant 0.23 rifampicin
rpoB 761813 c.2007T>C synonymous_variant 0.22 rifampicin
rpoB 761815 p.Ala670Glu missense_variant 0.23 rifampicin
rpoB 761834 c.2028T>C synonymous_variant 0.27 rifampicin
rpoB 761848 p.Cys681Ser missense_variant 0.26 rifampicin
rpoB 761852 c.2046C>G synonymous_variant 0.26 rifampicin
rpoB 761858 c.2052G>C synonymous_variant 0.27 rifampicin
rpoB 761873 c.2067A>C synonymous_variant 0.26 rifampicin
rpoB 761885 c.2079T>C synonymous_variant 0.24 rifampicin
rpoB 761906 c.2100C>G synonymous_variant 0.22 rifampicin
rpoB 761909 c.2103T>C synonymous_variant 0.2 rifampicin
rpoB 761912 c.2106T>C synonymous_variant 0.2 rifampicin
rpoB 761915 p.Asp703Glu missense_variant 0.2 rifampicin
rpoB 761916 p.Asp704Asn missense_variant 0.2 rifampicin
rpoB 761948 c.2142G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 761954 c.2148C>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 762008 c.2202C>T synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 762014 c.2208C>T synonymous_variant 0.29 rifampicin
rpoB 762017 c.2211A>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 762053 c.2247T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 762062 c.2256T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 762083 c.2277T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 762086 c.2280G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 762101 c.2295C>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 762114 p.Ile770Val missense_variant 0.29 rifampicin Uncertain significance
rpoB 762131 c.2325C>G synonymous_variant 0.28 rifampicin
rpoB 762140 c.2334G>C synonymous_variant 0.24 rifampicin
rpoB 762143 c.2337T>C synonymous_variant 0.25 rifampicin
rpoB 762149 c.2343G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 762167 c.2361T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 762176 c.2370T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 762185 c.2379G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 762206 c.2400C>G synonymous_variant 0.21 rifampicin
rpoB 762233 c.2427G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 762246 c.2440C>T synonymous_variant 0.2 rifampicin
rpoB 762254 c.2448T>G synonymous_variant 0.2 rifampicin
rpoB 762257 c.2451C>G synonymous_variant 0.2 rifampicin
rpoB 762266 c.2460T>C synonymous_variant 0.19 rifampicin
rpoB 762284 c.2478G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 762293 c.2487T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 762314 c.2508C>T synonymous_variant 0.25 rifampicin
rpoB 762317 c.2511A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 762329 c.2523G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 762338 c.2532T>C synonymous_variant 0.23 rifampicin
rpoB 762347 c.2541T>C synonymous_variant 0.24 rifampicin
rpoB 762362 p.Glu852Asp missense_variant 0.24 rifampicin
rpoB 762369 c.2563T>C synonymous_variant 0.25 rifampicin
rpoC 762398 c.-972T>C upstream_gene_variant 0.27 rifampicin
rpoC 762401 c.-969G>C upstream_gene_variant 0.26 rifampicin
rpoB 762404 c.2598T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 762410 c.-960T>C upstream_gene_variant 0.27 rifampicin
rpoB 762416 c.2610A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 762419 c.-951C>G upstream_gene_variant 0.27 rifampicin
rpoC 762434 c.-936T>C upstream_gene_variant 0.26 rifampicin
rpoB 762449 c.2643C>A synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 762467 c.-903C>T upstream_gene_variant 0.23 rifampicin
rpoB 762488 c.2682G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 762489 p.Val895Gln missense_variant 0.16 rifampicin
rpoC 762509 c.-861T>G upstream_gene_variant 0.17 rifampicin
rpoB 762510 p.Ala902Pro missense_variant 0.17 rifampicin Uncertain significance
rpoC 762521 c.-849C>T upstream_gene_variant 0.15 rifampicin
rpoB 762857 c.3051C>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 762860 c.3054G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 762863 c.3057T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 762929 c.3123G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 762989 c.-381G>C upstream_gene_variant 0.31 rifampicin
rpoC 763013 c.-357C>G upstream_gene_variant 0.29 rifampicin
rpoB 763028 c.3222T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 763034 c.3228C>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 763040 c.3234C>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 763070 c.3264T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 763085 c.3279C>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 763115 c.3309T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 763136 c.3330C>T synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 763148 c.-222G>C upstream_gene_variant 0.33 rifampicin
rpoC 763158 c.-212C>T upstream_gene_variant 0.27 rifampicin
rpoB 763166 c.3360A>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 763190 c.-180C>T upstream_gene_variant 0.27 rifampicin
rpoC 763202 c.-168A>G upstream_gene_variant 0.25 rifampicin
rpoC 763205 c.-165G>C upstream_gene_variant 0.18 rifampicin
rpoC 763206 c.-164_-162delAGTinsTCG upstream_gene_variant 0.18 rifampicin
rpoB 763214 c.3408T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 763226 c.-144A>G upstream_gene_variant 0.2 rifampicin
rpoB 763227 c.3421C>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 763238 c.3432T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 763253 c.-117G>C upstream_gene_variant 0.16 rifampicin
rpoC 763256 c.-114G>A upstream_gene_variant 0.16 rifampicin
rpoB 763268 c.3462C>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 763402 c.33C>G synonymous_variant 0.17 rifampicin
rpoC 763411 c.42T>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 763414 c.45T>C synonymous_variant 0.19 rifampicin
rpoC 763441 c.72C>T synonymous_variant 0.27 rifampicin
rpoC 763444 c.75T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 763456 c.87A>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 763486 c.117T>G synonymous_variant 0.35 rifampicin
rpoC 763528 c.159G>A synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 763573 c.204G>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 763594 c.225C>T synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 763633 c.264T>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 763636 c.267T>C synonymous_variant 0.38 rifampicin
rpoC 763660 c.291T>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 763675 c.306C>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 763696 c.327T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 763702 c.333C>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 763717 c.348T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 763723 c.354G>C synonymous_variant 0.27 rifampicin
rpoC 763732 c.363C>G synonymous_variant 0.27 rifampicin
rpoC 763741 c.372C>T synonymous_variant 0.24 rifampicin
rpoC 763744 c.375G>C synonymous_variant 0.24 rifampicin
rpoC 763765 c.396T>C synonymous_variant 0.22 rifampicin
rpoC 763774 c.405G>C synonymous_variant 0.22 rifampicin
rpoC 763807 c.438T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 763816 c.447C>G synonymous_variant 0.18 rifampicin
rpoC 763835 p.Ala156Met missense_variant 0.17 rifampicin
rpoC 763853 p.Val162Ile missense_variant 0.16 rifampicin
rpoC 763858 c.489A>G synonymous_variant 0.15 rifampicin
rpoC 763872 p.Gly168Ala missense_variant 0.15 rifampicin
rpoC 763876 p.Glu169Asp missense_variant 0.15 rifampicin
rpoC 763877 c.508_510delCTAinsTTG synonymous_variant 0.15 rifampicin
rpoC 763888 c.519G>C synonymous_variant 0.15 rifampicin
rpoC 763891 c.522G>C synonymous_variant 0.15 rifampicin
rpoC 763894 c.525A>G synonymous_variant 0.15 rifampicin
rpoC 763900 c.531G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 763936 c.567C>G synonymous_variant 0.24 rifampicin
rpoC 763945 c.576T>C synonymous_variant 0.24 rifampicin
rpoC 763951 c.582G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 763960 c.591T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 763991 p.Ile208Leu missense_variant 0.23 rifampicin
rpoC 763996 c.627T>C synonymous_variant 0.23 rifampicin
rpoC 764002 c.633C>G synonymous_variant 0.24 rifampicin
rpoC 764005 c.636G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764024 c.655_657delTTGinsCTC synonymous_variant 0.24 rifampicin
rpoC 764032 p.Asp221Glu missense_variant 0.22 rifampicin
rpoC 764040 p.Ser224Thr missense_variant 0.23 rifampicin
rpoC 764044 c.675T>C synonymous_variant 0.25 rifampicin
rpoC 764059 c.690G>T synonymous_variant 0.25 rifampicin
rpoC 764083 c.714A>G synonymous_variant 0.21 rifampicin
rpoC 764098 c.729A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 764101 c.732C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 764102 p.Val245Ile missense_variant 0.16 rifampicin
rpoC 764112 p.Tyr248Phe missense_variant 0.18 rifampicin
rpoC 764116 c.747C>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764131 c.762T>C synonymous_variant 0.22 rifampicin
rpoC 764140 c.771C>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764188 c.819A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764195 p.Ser276Ile missense_variant 0.2 rifampicin
rpoC 764203 c.834G>C synonymous_variant 0.2 rifampicin
rpoC 764206 c.837T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764215 c.846A>G synonymous_variant 0.21 rifampicin
rpoC 764236 c.867G>A synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764248 c.879C>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 764257 c.888G>C synonymous_variant 0.21 rifampicin
rpoC 764266 c.897T>C synonymous_variant 0.22 rifampicin
rpoC 764269 c.900G>C synonymous_variant 0.22 rifampicin
rpoC 764272 c.903G>C synonymous_variant 0.22 rifampicin
rpoC 764278 c.909A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764353 c.984G>C synonymous_variant 0.17 rifampicin
rpoC 764365 c.996C>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764380 c.1011G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764381 c.1012_1013delTCinsAG synonymous_variant 0.17 rifampicin
rpoC 764387 c.1018_1020delTTGinsCTC synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764405 c.1036A>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764419 c.1050C>G synonymous_variant 0.22 rifampicin
rpoC 764428 c.1059G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764431 c.1062G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764434 c.1065A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764446 c.1077T>C synonymous_variant 0.22 rifampicin
rpoC 764449 c.1080G>C synonymous_variant 0.21 rifampicin
rpoC 764452 c.1083T>C synonymous_variant 0.22 rifampicin
rpoC 764458 c.1089G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764461 c.1092A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764489 c.1120C>T synonymous_variant 0.31 rifampicin
rpoC 764497 c.1128A>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 764510 c.1141C>T synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 764521 c.1152T>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 764527 c.1158C>T synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 764536 c.1167G>C synonymous_variant 0.38 rifampicin
rpoC 764539 c.1170C>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 764554 c.1185C>T synonymous_variant 0.38 rifampicin
rpoC 764560 c.1191T>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 764566 c.1197C>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 764575 c.1206T>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 764581 c.1212T>C synonymous_variant 0.37 rifampicin
rpoC 764593 c.1224C>T synonymous_variant 0.37 rifampicin
rpoC 764611 c.1242G>T synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>C synonymous_variant 0.31 rifampicin
rpoC 764651 c.1282_1284delTCGinsAGC synonymous_variant 0.31 rifampicin
rpoC 764752 c.1383G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764764 c.1395T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 764809 c.1440C>T synonymous_variant 0.24 rifampicin Not assoc w R
rpoC 764815 c.1446A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 764827 c.1458G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 764858 c.1489T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 764872 c.1503A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 764888 c.1519T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 764911 c.1542A>G synonymous_variant 0.24 rifampicin
rpoC 764932 c.1563C>A synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764935 c.1566T>C synonymous_variant 0.23 rifampicin
rpoC 764948 c.1579T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 764968 c.1599T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 764995 c.1626C>G synonymous_variant 0.23 rifampicin Not assoc w R
rpoC 765019 c.1650A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 765034 c.1665T>C synonymous_variant 0.21 rifampicin
rpoC 765040 c.1671T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 765041 c.1672T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 765047 c.1678T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 765053 c.1684_1685delTCinsAG synonymous_variant 0.16 rifampicin
rpoC 765346 c.1977C>G synonymous_variant 0.17 rifampicin
rpoC 765349 c.1980T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 765352 c.1983G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 765383 p.Met672Leu missense_variant 0.2 rifampicin Uncertain significance
rpoC 765404 p.Leu679Val missense_variant 0.21 rifampicin
rpoC 765409 c.2040T>C synonymous_variant 0.18 rifampicin
rpoC 765421 c.2052C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 765478 c.2109T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 765499 c.2130C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 765529 c.2160C>T synonymous_variant 0.25 rifampicin
rpoC 765541 c.2172C>G synonymous_variant 0.25 rifampicin
rpoC 765553 c.2184C>T synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 765556 c.2187G>C synonymous_variant 0.27 rifampicin
rpoC 765559 c.2190G>C synonymous_variant 0.27 rifampicin
rpoC 765580 c.2211G>C synonymous_variant 0.29 rifampicin
rpoC 765613 p.His748Gln missense_variant 0.28 rifampicin
rpoC 765625 c.2256C>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 765631 p.Asp754Glu missense_variant 0.31 rifampicin
rpoC 765700 c.2331T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 765734 c.2365T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 765739 c.2370G>T synonymous_variant 0.32 rifampicin
rpoC 765751 c.2382C>G synonymous_variant 0.33 rifampicin
rpoC 765753 p.Asp795Ala missense_variant 0.33 rifampicin Uncertain significance
rpoC 765772 c.2403C>G synonymous_variant 0.34 rifampicin
rpoC 765784 c.2415C>G synonymous_variant 0.3 rifampicin
rpoC 765787 c.2418C>T synonymous_variant 0.3 rifampicin
rpoC 765793 c.2424C>G synonymous_variant 0.3 rifampicin
rpoC 765796 c.2427C>T synonymous_variant 0.29 rifampicin
rpoC 765811 c.2442T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 765814 c.2445A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 765826 c.2457T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 765835 c.2466C>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 765850 c.2481G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 765883 c.2514C>G synonymous_variant 0.23 rifampicin
rpoC 765886 c.2517C>G synonymous_variant 0.22 rifampicin
rpoC 765892 c.2523T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 765937 c.2568T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 765967 c.2598C>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 765982 c.2613C>G synonymous_variant 0.21 rifampicin
rpoC 765994 c.2625A>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 766010 c.2641_2642delTCinsAG synonymous_variant 0.18 rifampicin
rpoC 766021 c.2652G>C synonymous_variant 0.19 rifampicin
rpoC 766027 c.2658G>C synonymous_variant 0.19 rifampicin
rpoC 766030 c.2661C>G synonymous_variant 0.2 rifampicin
rpoC 766036 c.2667C>T synonymous_variant 0.2 rifampicin
rpoC 766043 p.Gln892Glu missense_variant 0.19 rifampicin
rpoC 766054 c.2685C>G synonymous_variant 0.19 rifampicin
rpoC 766082 p.Ala905Gln missense_variant 0.18 rifampicin
rpoC 766085 p.Pro906Ala missense_variant 0.81 rifampicin Not assoc w R
rpoC 766096 c.2727G>C synonymous_variant 0.19 rifampicin
rpoC 766129 c.2760C>G synonymous_variant 0.15 rifampicin
rpoC 766142 c.2773C>T synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 766168 c.2799C>T synonymous_variant 0.14 rifampicin
rpoC 766273 c.2904T>C synonymous_variant 0.2 rifampicin
rpoC 766274 p.Ala969Thr missense_variant 0.23 rifampicin
rpoC 766280 p.Ser971Gly missense_variant 0.23 rifampicin
rpoC 766288 c.2919C>G synonymous_variant 0.25 rifampicin
rpoC 766303 c.2934C>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 766312 c.2943T>G synonymous_variant 0.23 rifampicin
rpoC 766327 c.2958C>A synonymous_variant 0.21 rifampicin
rpoC 766345 c.2976T>C synonymous_variant 0.21 rifampicin
rpoC 766348 c.2979A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 766357 c.2988C>T synonymous_variant 0.23 rifampicin
rpoC 766363 c.2994G>C synonymous_variant 0.23 rifampicin
rpoC 766381 c.3012C>T synonymous_variant 0.23 rifampicin
rpoC 766384 c.3015A>G synonymous_variant 0.24 rifampicin
rpoC 766408 c.3039C>G synonymous_variant 0.22 rifampicin
rpoC 766411 c.3042C>G synonymous_variant 0.22 rifampicin
rpoC 766426 c.3057C>T synonymous_variant 0.25 rifampicin
rpoC 766447 c.3078T>C synonymous_variant 0.26 rifampicin
rpoC 766462 c.3093G>C synonymous_variant 0.25 rifampicin
rpoC 766483 c.3114G>C synonymous_variant 0.24 rifampicin
rpoC 766484 p.Val1039Ile missense_variant 0.24 rifampicin Uncertain significance
rpoC 766492 c.3123T>C synonymous_variant 0.28 rifampicin
rpoC 766522 c.3153C>G synonymous_variant 0.28 rifampicin
rpoC 766528 c.3159T>C synonymous_variant 0.26 rifampicin
rpoC 766531 c.3162G>C synonymous_variant 0.25 rifampicin
rpoC 766540 p.Asp1057Glu missense_variant 0.27 rifampicin
rpoC 766549 c.3180G>C synonymous_variant 0.28 rifampicin
rpoC 766573 c.3204T>C synonymous_variant 0.2 rifampicin
rpoC 766582 c.3213C>G synonymous_variant 0.19 rifampicin
rpoC 766583 p.Gly1072Ser missense_variant 0.19 rifampicin
rpoC 766591 c.3222A>G synonymous_variant 0.19 rifampicin
rpoC 766594 c.3225G>C synonymous_variant 0.22 rifampicin
rpoC 766597 c.3228C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 766607 p.Ile1080Leu missense_variant 0.22 rifampicin
rpoC 766630 c.3261G>C synonymous_variant 0.25 rifampicin
rpoC 766657 c.3288A>G synonymous_variant 0.26 rifampicin
mmpL5 775639 p.Ile948Val missense_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rplC 800612 c.-197A>G upstream_gene_variant 0.16 linezolid
rplC 800618 c.-191T>C upstream_gene_variant 0.15 linezolid
rplC 800627 c.-182C>T upstream_gene_variant 0.15 linezolid
rplC 800648 c.-161A>T upstream_gene_variant 0.18 linezolid
rplC 800654 c.-155T>C upstream_gene_variant 0.18 linezolid
rplC 800693 c.-116A>G upstream_gene_variant 0.19 linezolid
rplC 800703 c.-106T>C upstream_gene_variant 0.18 linezolid
rplC 800715 c.-94A>C upstream_gene_variant 0.18 linezolid
rplC 800720 c.-89T>C upstream_gene_variant 0.18 linezolid
rplC 800723 c.-86C>G upstream_gene_variant 0.18 linezolid
rplC 800747 c.-62C>G upstream_gene_variant 0.17 linezolid
atpE 1460992 c.-53A>C upstream_gene_variant 1.0 bedaquiline
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 kanamycin
capreomycin
streptomycin
amikacin
rrs 1471969 n.124T>C non_coding_transcript_exon_variant 0.17 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1471970 n.125G>A non_coding_transcript_exon_variant 0.17 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472028 n.183A>T non_coding_transcript_exon_variant 0.24 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472029 n.184C>T non_coding_transcript_exon_variant 0.23 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472030 n.185G>T non_coding_transcript_exon_variant 0.23 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472031 n.186G>A non_coding_transcript_exon_variant 0.23 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472033 n.188A>G non_coding_transcript_exon_variant 0.24 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472034 n.189T>C non_coding_transcript_exon_variant 0.26 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472044 n.199G>T non_coding_transcript_exon_variant 0.27 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472045 n.200T>A non_coding_transcript_exon_variant 0.27 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472053 n.211_212delGC non_coding_transcript_exon_variant 0.28 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472061 n.216A>T non_coding_transcript_exon_variant 0.28 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472075 n.230A>G non_coding_transcript_exon_variant 0.31 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.3 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472969 n.1124A>G non_coding_transcript_exon_variant 0.29 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472970 n.1125C>G non_coding_transcript_exon_variant 0.29 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472977 n.1132G>C non_coding_transcript_exon_variant 0.29 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472978 n.1133T>C non_coding_transcript_exon_variant 0.29 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473105 n.1260G>A non_coding_transcript_exon_variant 0.29 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1473123 n.1278delAinsTT non_coding_transcript_exon_variant 0.29 kanamycin
capreomycin
streptomycin
amikacin
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.34 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.34 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473290 n.1445C>T non_coding_transcript_exon_variant 0.15 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrl 1473756 n.99G>A non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1473758 n.101G>T non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid
rrl 1473806 n.149C>T non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473832 n.175C>T non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid
rrl 1473877 n.220G>A non_coding_transcript_exon_variant 0.38 capreomycin
linezolid
rrl 1473898 n.241C>T non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473943 n.286G>T non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid
rrl 1473945 n.288T>A non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid
rrl 1473946 n.289A>T non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid
rrl 1473986 n.329T>C non_coding_transcript_exon_variant 0.32 capreomycin
linezolid
rrl 1473987 n.330G>A non_coding_transcript_exon_variant 0.32 capreomycin
linezolid
rrl 1473995 n.338G>T non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1474001 n.344C>T non_coding_transcript_exon_variant 1.0 capreomycin Not assoc w R
linezolid Not assoc w R
rrl 1474009 n.352A>G non_coding_transcript_exon_variant 0.36 capreomycin
linezolid
rrl 1474012 n.355C>T non_coding_transcript_exon_variant 0.36 capreomycin
linezolid
rrl 1474093 n.436G>T non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1474099 n.442G>A non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1474103 n.446A>T non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1474140 n.483C>T non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474181 n.524C>T non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid
rrl 1474308 n.651G>T non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474310 n.653T>G non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1474356 n.699T>C non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid
rrl 1474362 n.705A>G non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474376 n.719T>C non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1474409 n.756_766delACCCACACGCG non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1474427 n.770A>C non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1474429 n.772G>C non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1474431 n.774_775delGCinsTTTGGG non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1474435 n.780_783delGAAT non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1474639 n.982G>A non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474823 n.1166C>T non_coding_transcript_exon_variant 0.34 capreomycin
linezolid
rrl 1474831 n.1174A>G non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid
rrl 1474904 n.1247G>A non_coding_transcript_exon_variant 0.31 capreomycin
linezolid
rrl 1475006 n.1349A>T non_coding_transcript_exon_variant 0.31 capreomycin
linezolid
rrl 1475061 n.1404C>T non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid
rrl 1475088 n.1431A>T non_coding_transcript_exon_variant 0.32 capreomycin
linezolid
rrl 1475199 n.1542G>A non_coding_transcript_exon_variant 0.28 capreomycin
linezolid
rrl 1475206 n.1549C>T non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid
rrl 1475209 n.1552G>C non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid
rrl 1475213 n.1556C>T non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid
rrl 1475249 n.1592T>C non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475252 n.1595C>T non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1475266 n.1609T>C non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475267 n.1610G>A non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1475275 n.1618C>T non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1475276 n.1619T>C non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1475291 n.1634A>C non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475313 n.1656G>A non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1475315 n.1658A>T non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475355 n.1698C>T non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475505 n.1848G>A non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475599 n.1942A>G non_coding_transcript_exon_variant 0.21 capreomycin
linezolid Uncertain significance
rrl 1475608 n.1951T>C non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid
rrl 1475642 n.1985T>C non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1475657 n.2000A>G non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1475659 n.2002G>T non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1475761 n.2104_2106delCGCinsGT non_coding_transcript_exon_variant 0.32 capreomycin
linezolid
rrl 1475765 n.2111delG non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1475881 n.2224T>C non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.19 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476031 n.2374C>T non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1476032 n.2375C>A non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1476033 n.2376T>C non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid
rrl 1476034 n.2377C>A non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid
rrl 1476045 n.2388G>T non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid
rrl 1476047 n.2390G>T non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1476048 n.2391G>A non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1476049 n.2392C>T non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476086 n.2429G>A non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476089 n.2432T>C non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1476095 n.2438C>G non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1476103 n.2446C>G non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid
rrl 1476105 n.2448G>A non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid
rrl 1476106 n.2449A>T non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid
rrl 1476110 n.2453G>C non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid
rrl 1476115 n.2458T>C non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476117 n.2460G>C non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
rrl 1476131 n.2474C>T non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476215 n.2558C>T non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid Uncertain significance
rpsA 1833661 c.120A>G synonymous_variant 0.26 pyrazinamide
rpsA 1833667 c.126C>G synonymous_variant 0.26 pyrazinamide
rpsA 1833721 c.180A>G synonymous_variant 0.31 pyrazinamide
rpsA 1833724 c.183C>G synonymous_variant 0.3 pyrazinamide
rpsA 1833727 c.186G>C synonymous_variant 0.29 pyrazinamide
rpsA 1833742 c.201A>G synonymous_variant 0.29 pyrazinamide
rpsA 1833745 c.204G>C synonymous_variant 0.29 pyrazinamide
rpsA 1833748 c.207C>G synonymous_variant 0.3 pyrazinamide
rpsA 1833787 c.246C>G synonymous_variant 0.35 pyrazinamide
rpsA 1833790 c.249T>C synonymous_variant 0.35 pyrazinamide
rpsA 1833802 c.261A>G synonymous_variant 0.36 pyrazinamide
rpsA 1833811 c.270G>T synonymous_variant 0.34 pyrazinamide
rpsA 1833838 c.297G>C synonymous_variant 0.27 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.3 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.3 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.32 pyrazinamide
rpsA 1833874 c.333T>C synonymous_variant 0.24 pyrazinamide
rpsA 1833886 c.345C>G synonymous_variant 0.23 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.22 pyrazinamide
rpsA 1833940 c.399C>G synonymous_variant 0.2 pyrazinamide
rpsA 1833971 c.430C>T synonymous_variant 0.19 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.21 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.2 pyrazinamide
rpsA 1834021 c.480C>T synonymous_variant 0.18 pyrazinamide
rpsA 1834030 c.489C>G synonymous_variant 0.17 pyrazinamide
rpsA 1834081 c.540C>T synonymous_variant 0.19 pyrazinamide
rpsA 1834096 c.555G>C synonymous_variant 0.18 pyrazinamide
rpsA 1834099 c.558C>G synonymous_variant 0.18 pyrazinamide
rpsA 1834102 c.561T>C synonymous_variant 0.19 pyrazinamide
rpsA 1834105 c.564C>G synonymous_variant 0.19 pyrazinamide
rpsA 1834108 c.567C>G synonymous_variant 0.2 pyrazinamide
rpsA 1834123 c.582C>G synonymous_variant 0.19 pyrazinamide
rpsA 1834150 c.609G>C synonymous_variant 0.2 pyrazinamide
rpsA 1834153 c.612T>C synonymous_variant 0.19 pyrazinamide
rpsA 1834154 p.Asn205Gln missense_variant 0.19 pyrazinamide
rpsA 1834157 c.616T>C synonymous_variant 0.19 pyrazinamide
rpsA 1834162 c.621A>G synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
rpsA 1834165 c.624A>G synonymous_variant 0.2 pyrazinamide
rpsA 1834169 p.Thr210Ala missense_variant 0.2 pyrazinamide Uncertain significance
rpsA 1834177 c.636A>C synonymous_variant 0.22 pyrazinamide Not assoc w R - Interim
rpsA 1834189 c.648G>C synonymous_variant 0.28 pyrazinamide
rpsA 1834195 c.654G>C synonymous_variant 0.28 pyrazinamide
rpsA 1834210 c.669C>T synonymous_variant 0.25 pyrazinamide
rpsA 1834222 c.681T>C synonymous_variant 0.25 pyrazinamide
rpsA 1834231 c.690T>C synonymous_variant 0.24 pyrazinamide
rpsA 1834234 c.693G>C synonymous_variant 0.24 pyrazinamide
rpsA 1834249 c.708T>C synonymous_variant 0.26 pyrazinamide
rpsA 1834261 c.720A>G synonymous_variant 0.23 pyrazinamide Not assoc w R - Interim
rpsA 1834262 c.721_723delTCGinsAGC synonymous_variant 0.23 pyrazinamide
rpsA 1834303 c.762T>C synonymous_variant 0.25 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.25 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 0.28 pyrazinamide Not assoc w R - Interim
rpsA 1834366 c.825A>G synonymous_variant 0.28 pyrazinamide Not assoc w R - Interim
rpsA 1834396 c.855G>C synonymous_variant 0.28 pyrazinamide
rpsA 1834411 c.870T>C synonymous_variant 0.28 pyrazinamide
rpsA 1834417 c.876G>C synonymous_variant 0.25 pyrazinamide
rpsA 1834423 c.882G>C synonymous_variant 0.25 pyrazinamide
rpsA 1834435 c.894G>C synonymous_variant 0.18 pyrazinamide
rpsA 1834451 c.910T>C synonymous_variant 0.17 pyrazinamide
rpsA 1834465 c.924T>C synonymous_variant 0.18 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.16 pyrazinamide
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
Rv1979c 2223492 c.-328G>C upstream_gene_variant 1.0 bedaquiline Uncertain significance
clofazimine Uncertain significance
kasA 2518588 c.474T>C synonymous_variant 0.16 isoniazid
kasA 2518591 c.477G>C synonymous_variant 0.16 isoniazid
kasA 2518609 p.Met165Ile missense_variant 0.18 isoniazid
kasA 2518624 c.510C>G synonymous_variant 0.17 isoniazid
kasA 2518639 c.525G>C synonymous_variant 0.22 isoniazid
kasA 2518678 c.564C>T synonymous_variant 0.25 isoniazid
kasA 2518684 c.570C>G synonymous_variant 0.25 isoniazid
kasA 2518825 c.711T>C synonymous_variant 0.24 isoniazid
kasA 2518864 c.750G>C synonymous_variant 0.23 isoniazid
kasA 2518879 c.765A>G synonymous_variant 0.24 isoniazid
kasA 2518885 c.771T>C synonymous_variant 0.2 isoniazid
kasA 2518898 c.784T>C synonymous_variant 0.2 isoniazid
kasA 2518906 c.792A>G synonymous_variant 0.19 isoniazid
kasA 2518910 p.Leu266Met missense_variant 0.19 isoniazid
kasA 2518921 c.807T>C synonymous_variant 0.17 isoniazid
kasA 2518936 c.822C>G synonymous_variant 0.17 isoniazid
kasA 2518939 c.825T>C synonymous_variant 0.17 isoniazid
kasA 2518942 c.828T>C synonymous_variant 0.18 isoniazid
kasA 2518951 c.837G>C synonymous_variant 0.2 isoniazid
kasA 2518954 c.840C>G synonymous_variant 0.2 isoniazid
kasA 2518963 c.849T>C synonymous_variant 0.2 isoniazid
kasA 2518969 c.855T>G synonymous_variant 0.18 isoniazid
kasA 2518975 c.861C>G synonymous_variant 0.18 isoniazid
kasA 2518979 c.865A>C synonymous_variant 0.18 isoniazid
kasA 2518990 c.876T>G synonymous_variant 0.16 isoniazid
kasA 2518993 c.879C>G synonymous_variant 0.16 isoniazid
kasA 2518999 c.885G>C synonymous_variant 0.16 isoniazid
kasA 2519008 c.894C>G synonymous_variant 0.16 isoniazid
kasA 2519017 c.903G>C synonymous_variant 0.15 isoniazid
kasA 2519020 c.906G>C synonymous_variant 0.15 isoniazid
kasA 2519021 p.Ala303Lys missense_variant 0.15 isoniazid
kasA 2519027 p.Ile305Val missense_variant 0.15 isoniazid
kasA 2519050 c.936C>G synonymous_variant 0.17 isoniazid
kasA 2519053 c.939G>C synonymous_variant 0.17 isoniazid
kasA 2519056 c.942G>C synonymous_variant 0.17 isoniazid
kasA 2519062 c.948T>G synonymous_variant 0.17 isoniazid
kasA 2519068 c.954C>T synonymous_variant 0.18 isoniazid
kasA 2519072 p.Ala320Thr missense_variant 0.2 isoniazid
kasA 2519095 c.981C>A synonymous_variant 0.2 isoniazid
kasA 2519107 c.993T>C synonymous_variant 0.16 isoniazid
kasA 2519108 p.Asp332Gln missense_variant 0.16 isoniazid
kasA 2519116 c.1002C>G synonymous_variant 0.18 isoniazid
kasA 2519122 c.1008G>C synonymous_variant 0.2 isoniazid
kasA 2519137 c.1023T>G synonymous_variant 0.2 isoniazid
kasA 2519167 c.1053T>G synonymous_variant 0.21 isoniazid
Rv2477c 2782869 p.Ala392Thr missense_variant 0.23 kanamycin Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
streptomycin
rifampicin Uncertain significance
ethambutol Uncertain significance
amikacin Uncertain significance
Rv2477c 2782876 c.1167G>C synonymous_variant 0.24 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782882 c.1161T>C synonymous_variant 0.23 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783557 c.486T>C synonymous_variant 0.16 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783656 c.387G>C synonymous_variant 0.22 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783665 c.378A>G synonymous_variant 0.21 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783674 c.369T>C synonymous_variant 0.24 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783683 c.360A>G synonymous_variant 0.26 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783700 p.Thr115Ser missense_variant 0.25 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783718 c.325T>C synonymous_variant 0.24 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783719 c.324A>G synonymous_variant 0.25 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783751 p.Ile98Val missense_variant 0.25 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783758 p.Asp95Glu missense_variant 0.25 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783761 c.282G>C synonymous_variant 0.25 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783766 p.Met93Leu missense_variant 0.25 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783776 c.267G>C synonymous_variant 0.21 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783779 c.264T>C synonymous_variant 0.22 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783797 p.Asp82Glu missense_variant 0.24 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783815 c.228A>G synonymous_variant 0.22 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783821 p.Gln74Leu missense_variant 0.2 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783833 c.210G>C synonymous_variant 0.24 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783839 c.204C>G synonymous_variant 0.26 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783843 p.Gly67Asp missense_variant 0.26 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783846 p.Thr66Asn missense_variant 0.26 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783860 c.183T>C synonymous_variant 0.25 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783863 c.180C>T synonymous_variant 0.25 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2752c 3064673 p.Ala507Ser missense_variant 0.98 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
thyA 3074127 c.345G>C synonymous_variant 0.14 para-aminosalicylic_acid
Rv3083 3448507 c.5_*1408del frameshift_variant&stop_lost&splice_region_variant 1.0 ethionamide Uncertain significance
mtrB 3626972 c.-359A>G upstream_gene_variant 0.26 rifampicin
bedaquiline
mtrB 3626987 c.-374C>G upstream_gene_variant 0.25 rifampicin
bedaquiline
mtrB 3627008 c.-395G>C upstream_gene_variant 0.25 rifampicin
bedaquiline
mtrB 3627011 c.-398T>G upstream_gene_variant 0.26 rifampicin
bedaquiline
mtrB 3627065 c.-452G>C upstream_gene_variant 0.24 rifampicin
bedaquiline
mtrA 3627068 c.282T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
bedaquiline
mtrA 3627071 c.279G>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627074 c.-461G>C upstream_gene_variant 0.26 rifampicin
bedaquiline
mtrA 3627080 c.270T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627083 c.-470G>C upstream_gene_variant 0.26 rifampicin
bedaquiline
mtrA 3627098 c.252A>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627104 c.-491C>G upstream_gene_variant 0.3 rifampicin
bedaquiline
mtrA 3627119 c.231T>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627122 c.-509T>C upstream_gene_variant 0.27 rifampicin
bedaquiline
mtrB 3627167 c.-554T>C upstream_gene_variant 0.24 rifampicin
bedaquiline
mtrB 3627181 c.-568T>C upstream_gene_variant 0.25 rifampicin
bedaquiline
mtrB 3627182 c.-569T>C upstream_gene_variant 0.25 rifampicin
bedaquiline
mtrA 3627188 c.162A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627209 c.-596G>A upstream_gene_variant 0.24 rifampicin
bedaquiline
mtrA 3627221 c.129C>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
bedaquiline
mtrA 3627227 c.123T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627233 c.-620T>C upstream_gene_variant 0.22 rifampicin
bedaquiline
mtrB 3627236 c.-623T>C upstream_gene_variant 0.21 rifampicin
bedaquiline
mtrA 3627242 c.108C>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627254 c.-641C>T upstream_gene_variant 0.2 rifampicin
bedaquiline
mtrB 3627263 c.-650C>T upstream_gene_variant 0.18 rifampicin
bedaquiline
mtrB 3627266 c.-653A>G upstream_gene_variant 0.18 rifampicin
bedaquiline
mtrB 3627272 c.-659G>T upstream_gene_variant 0.17 rifampicin
bedaquiline
mtrB 3627275 c.-662G>T upstream_gene_variant 0.17 rifampicin
bedaquiline
mtrB 3627296 c.-683T>C upstream_gene_variant 0.15 rifampicin
bedaquiline
mtrA 3627299 c.51G>A synonymous_variant 0.14 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627314 c.-701C>T upstream_gene_variant 0.13 rifampicin
bedaquiline
alr 3840764 c.657G>C synonymous_variant 1.0 cycloserine
clpC1 4038755 c.1950G>T synonymous_variant 0.16 pyrazinamide
clpC1 4038770 c.1935C>T synonymous_variant 0.16 pyrazinamide
clpC1 4038773 c.1932T>C synonymous_variant 0.16 pyrazinamide
clpC1 4038782 c.1923G>C synonymous_variant 0.17 pyrazinamide
clpC1 4038812 c.1893T>C synonymous_variant 0.17 pyrazinamide
clpC1 4038845 c.1860G>C synonymous_variant 0.15 pyrazinamide
clpC1 4038860 c.1845G>C synonymous_variant 0.16 pyrazinamide Not assoc w R - Interim
clpC1 4038908 c.1797C>G synonymous_variant 0.15 pyrazinamide
clpC1 4038914 c.1791G>C synonymous_variant 0.16 pyrazinamide
clpC1 4038923 c.1782A>G synonymous_variant 0.17 pyrazinamide
clpC1 4038953 c.1752A>G synonymous_variant 0.19 pyrazinamide
clpC1 4038956 c.1749T>C synonymous_variant 0.18 pyrazinamide
clpC1 4038965 c.1740T>C synonymous_variant 0.19 pyrazinamide
clpC1 4038971 c.1734T>C synonymous_variant 0.19 pyrazinamide
clpC1 4038974 c.1731T>C synonymous_variant 0.18 pyrazinamide Not assoc w R - Interim
clpC1 4038989 c.1716T>C synonymous_variant 0.19 pyrazinamide
clpC1 4038997 c.1708T>C synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
clpC1 4039004 c.1701C>G synonymous_variant 0.2 pyrazinamide
clpC1 4039022 c.1683A>G synonymous_variant 0.23 pyrazinamide
clpC1 4039064 c.1641C>T synonymous_variant 0.24 pyrazinamide
clpC1 4039097 c.1608G>C synonymous_variant 0.26 pyrazinamide
clpC1 4039103 c.1602T>C synonymous_variant 0.25 pyrazinamide
clpC1 4039106 c.1599G>C synonymous_variant 0.24 pyrazinamide
clpC1 4039112 c.1593C>G synonymous_variant 0.24 pyrazinamide
clpC1 4039121 c.1584T>C synonymous_variant 0.27 pyrazinamide
clpC1 4039142 c.1563A>G synonymous_variant 0.22 pyrazinamide
clpC1 4039145 c.1560G>C synonymous_variant 0.22 pyrazinamide
clpC1 4039169 p.Glu512Asp missense_variant 0.2 pyrazinamide
clpC1 4039172 c.1533A>G synonymous_variant 0.2 pyrazinamide
clpC1 4039178 c.1527G>C synonymous_variant 0.2 pyrazinamide
clpC1 4039183 c.1522T>C synonymous_variant 0.19 pyrazinamide
clpC1 4039186 c.1519C>T synonymous_variant 0.19 pyrazinamide
clpC1 4039226 c.1479T>C synonymous_variant 0.16 pyrazinamide Not assoc w R - Interim
clpC1 4039979 c.726C>G synonymous_variant 0.15 pyrazinamide
clpC1 4039988 c.717C>G synonymous_variant 0.16 pyrazinamide
clpC1 4039991 c.714G>C synonymous_variant 0.16 pyrazinamide
clpC1 4040381 c.324T>C synonymous_variant 0.15 pyrazinamide
clpC1 4040387 c.318A>G synonymous_variant 0.15 pyrazinamide
clpC1 4040393 c.312G>C synonymous_variant 0.15 pyrazinamide Not assoc w R - Interim
clpC1 4040411 c.294T>C synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
clpC1 4040423 c.282A>G synonymous_variant 0.18 pyrazinamide Not assoc w R - Interim
clpC1 4040426 c.279T>C synonymous_variant 0.18 pyrazinamide
clpC1 4040431 c.274T>C synonymous_variant 0.19 pyrazinamide
clpC1 4040444 c.261C>T synonymous_variant 0.2 pyrazinamide
clpC1 4040450 c.255A>G synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
clpC1 4040459 c.246C>G synonymous_variant 0.19 pyrazinamide
clpC1 4040465 c.240T>C synonymous_variant 0.19 pyrazinamide
clpC1 4040471 c.234T>C synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
clpC1 4040477 c.228G>C synonymous_variant 0.19 pyrazinamide
clpC1 4040480 c.225T>G synonymous_variant 0.17 pyrazinamide
clpC1 4040522 c.183T>C synonymous_variant 0.15 pyrazinamide Not assoc w R - Interim
embC 4240699 c.837C>G synonymous_variant 0.15 ethambutol Not assoc w R - Interim
embC 4240726 c.864G>C synonymous_variant 0.16 ethambutol Not assoc w R - Interim
embC 4240780 c.918T>C synonymous_variant 0.18 ethambutol
embC 4240783 c.921G>C synonymous_variant 0.18 ethambutol
embC 4240789 c.927T>C synonymous_variant 0.17 ethambutol
embC 4240819 c.957A>G synonymous_variant 0.19 ethambutol
embC 4240828 c.966G>A synonymous_variant 0.22 ethambutol
embC 4240831 c.969T>G synonymous_variant 0.22 ethambutol
embC 4240867 c.1005T>C synonymous_variant 0.19 ethambutol
embC 4240870 c.1008T>C synonymous_variant 0.19 ethambutol
embC 4240873 c.1011C>G synonymous_variant 0.19 ethambutol
embC 4240879 c.1017G>C synonymous_variant 0.19 ethambutol
embC 4240880 p.Ala340Thr missense_variant 0.18 ethambutol Uncertain significance
embC 4240885 c.1023T>C synonymous_variant 0.17 ethambutol
embC 4240897 c.1035C>G synonymous_variant 0.16 ethambutol Not assoc w R
embC 4240898 c.1036_1038delCTAinsTTG synonymous_variant 0.16 ethambutol
embC 4240903 c.1041C>G synonymous_variant 0.16 ethambutol
embC 4240911 p.Ala350Val missense_variant 0.16 ethambutol
embC 4240921 c.1059C>G synonymous_variant 0.15 ethambutol
embC 4240924 c.1062C>G synonymous_variant 0.15 ethambutol
embC 4240996 c.1134G>C synonymous_variant 0.18 ethambutol
embC 4241002 c.1140G>C synonymous_variant 0.17 ethambutol
embC 4241013 p.Met384Thr missense_variant 0.18 ethambutol
embC 4241017 c.1155T>C synonymous_variant 0.17 ethambutol
embC 4241023 c.1161T>G synonymous_variant 0.19 ethambutol
embC 4241032 c.1170G>C synonymous_variant 0.19 ethambutol
embC 4241038 c.1176G>C synonymous_variant 0.18 ethambutol
embC 4241047 c.1185C>G synonymous_variant 0.18 ethambutol
embC 4241050 c.1188T>G synonymous_variant 0.18 ethambutol
embC 4241053 c.1191G>C synonymous_variant 0.18 ethambutol
embC 4242643 c.2781C>T synonymous_variant 0.98 ethambutol Not assoc w R
ubiA 4269164 p.Leu224Met missense_variant 0.14 ethambutol
aftB 4269179 c.-343C>A upstream_gene_variant 0.16 ethambutol
aftB 4269183 c.-347T>C upstream_gene_variant 0.15 ethambutol
aftB 4269186 c.-350C>G upstream_gene_variant 0.15 ethambutol
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R