TB-Profiler result

Run: ERR2446382
Summary

Run ID: ERR2446382

Sample name:

Date: 2024-10-05T05:47:10.391151

Number of reads: 2521275

Percentage reads mapped: 99.7

Median coverage: 18.0

Strain: lineage4

Spoligotype:

Drug-resistance: Other

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage4 Euro-American None 1.0
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol
pyrazinamide
streptomycin rrs n.888G>A Uncertain significance Mutation from literature
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
rrs 1472733 n.888G>A non_coding_transcript_exon_variant 0.39 streptomycin Uncertain significance Mutation from literature
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
dnaA 763 p.Lys255Arg missense_variant 0.44 isoniazid
dnaA 771 c.771A>G synonymous_variant 0.44 isoniazid
dnaA 793 p.Val265Ile missense_variant 0.4 isoniazid Uncertain significance
dnaA 801 c.801G>T synonymous_variant 0.42 isoniazid
dnaA 804 c.804G>C synonymous_variant 0.44 isoniazid
dnaA 805 c.805_807delTTGinsCTC synonymous_variant 0.42 isoniazid
dnaA 822 c.822A>G synonymous_variant 0.39 isoniazid
dnaA 828 c.828T>C synonymous_variant 0.44 isoniazid Not assoc w R - Interim
gyrA 6646 c.-656C>T upstream_gene_variant 0.32 levofloxacin
moxifloxacin
gyrA 6655 c.-647T>C upstream_gene_variant 0.33 levofloxacin
moxifloxacin
gyrA 6673 c.-629A>C upstream_gene_variant 0.4 levofloxacin
moxifloxacin
gyrA 6676 c.-626T>G upstream_gene_variant 0.4 levofloxacin
moxifloxacin
gyrA 6700 c.-602T>C upstream_gene_variant 0.36 levofloxacin
moxifloxacin
gyrA 6703 c.-599G>C upstream_gene_variant 0.37 levofloxacin
moxifloxacin
gyrA 6706 c.-596G>A upstream_gene_variant 0.4 levofloxacin
moxifloxacin
gyrA 6709 c.-593A>G upstream_gene_variant 0.4 levofloxacin
moxifloxacin
gyrA 6712 c.-590G>C upstream_gene_variant 0.4 levofloxacin
moxifloxacin
gyrA 6727 c.-575G>T upstream_gene_variant 0.36 levofloxacin
moxifloxacin
gyrA 6728 c.-574_-572delCTAinsTTG upstream_gene_variant 0.33 levofloxacin
moxifloxacin
gyrA 6754 c.-548C>T upstream_gene_variant 0.33 levofloxacin
moxifloxacin
gyrB 6763 c.1524G>C synonymous_variant 0.39 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6772 c.1533C>G synonymous_variant 0.41 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6775 c.1536G>C synonymous_variant 0.43 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6793 c.1554T>C synonymous_variant 0.48 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6798 p.Gly520Ala missense_variant 0.42 levofloxacin Not assoc w R
moxifloxacin Uncertain significance
gyrB 6808 c.1569C>G synonymous_variant 0.38 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6824 c.1585C>T synonymous_variant 0.41 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6841 c.1602T>C synonymous_variant 0.38 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6862 c.1623C>G synonymous_variant 0.4 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6869 c.-433T>C upstream_gene_variant 0.39 levofloxacin
moxifloxacin
gyrA 6872 c.-430_-428delTTGinsCTT upstream_gene_variant 0.39 levofloxacin
moxifloxacin
gyrB 6878 c.1639T>C synonymous_variant 0.41 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7574 c.273G>C synonymous_variant 0.38 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7589 c.288G>C synonymous_variant 0.35 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7595 c.294C>T synonymous_variant 0.4 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7607 c.306C>T synonymous_variant 0.4 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8921 c.1620C>T synonymous_variant 0.32 levofloxacin
moxifloxacin
gyrA 8942 c.1641G>C synonymous_variant 0.32 levofloxacin
moxifloxacin
gyrA 8945 c.1644G>C synonymous_variant 0.31 levofloxacin
moxifloxacin
gyrA 8946 c.1645T>C synonymous_variant 0.31 levofloxacin
moxifloxacin
gyrA 8957 c.1656C>T synonymous_variant 0.32 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8967 p.Ala556Lys missense_variant 0.3 levofloxacin
moxifloxacin
gyrA 8978 c.1677C>T synonymous_variant 0.28 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8987 c.1686C>G synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 8990 c.1689C>G synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 8993 c.1692C>T synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8996 c.1695T>C synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 8998 p.Leu566Trp missense_variant 0.25 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9018 p.Gln573Lys missense_variant 0.24 levofloxacin
moxifloxacin
gyrA 9171 p.Val624Leu missense_variant 1.0 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
nusG 734497 p.Val82Ile missense_variant 0.27 rifampicin Uncertain significance
nusG 734532 c.279A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
nusG 734535 c.282C>T synonymous_variant 0.27 rifampicin Not assoc w R - Interim
nusG 734538 c.285C>T synonymous_variant 0.27 rifampicin Not assoc w R - Interim
nusG 734541 c.288A>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
nusG 734559 c.306T>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
nusG 734580 c.327T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 760400 c.594G>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 760406 c.600G>C synonymous_variant 0.44 rifampicin
rpoB 760407 p.Ser201Gly missense_variant 0.44 rifampicin Uncertain significance
rpoB 760415 c.609C>T synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoB 760418 c.612G>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 760430 c.624T>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoB 760460 c.654G>C synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoB 760475 c.669A>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 760481 c.675G>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 760484 c.678A>G synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoB 760502 c.696C>G synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoB 760588 p.Thr261Ile missense_variant 0.64 rifampicin
rpoB 760591 p.Val262Ala missense_variant 0.7 rifampicin
rpoB 760595 c.789C>T synonymous_variant 0.7 rifampicin
rpoB 760596 p.Thr264Pro missense_variant 0.64 rifampicin
rpoB 760608 c.802C>T synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoB 760611 c.805T>C synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoB 760634 c.828T>C synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoB 760646 c.840C>G synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoB 760655 c.849A>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 760661 c.855A>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 760668 p.Thr288Ala missense_variant 0.5 rifampicin Uncertain significance
rpoB 760674 c.868T>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoB 760679 c.873A>G synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoB 760683 c.877T>C synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoB 761051 c.1245G>T synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoB 761054 c.1248G>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoB 761057 c.1251G>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoB 761060 c.1254C>G synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoB 761063 c.1257C>G synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoB 761084 c.1278C>A synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoB 761097 c.1291_1293delAGCinsTCG synonymous_variant 0.52 rifampicin
rpoB 761102 c.1296A>G synonymous_variant 0.52 rifampicin
rpoB 761132 c.1326G>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoB 761133 c.1327T>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoB 761147 c.1341C>T synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 761555 c.1749G>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 761558 c.1752C>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 761564 c.1758G>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 761570 c.1764T>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 761573 c.1767C>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 761579 c.1773G>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 761612 c.1806G>T synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 761615 c.1809A>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 761969 c.2163G>A synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 761990 c.2184G>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 762008 c.2202C>T synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 762014 c.2208C>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 762038 c.2232C>T synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoB 762047 c.2241G>A synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 762053 c.2247T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 762056 c.2250G>A synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 762450 p.Arg882Ser missense_variant 0.56 rifampicin
rpoB 762879 p.Met1025Leu missense_variant 0.5 rifampicin Uncertain significance
rpoB 762894 c.3088C>T synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoB 762899 c.3093G>C synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoB 762917 c.3111C>G synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoB 762920 c.3114C>T synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoB 762923 c.3117C>G synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoB 762929 c.3123G>C synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoB 762959 c.3153G>C synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoB 762962 c.3156C>T synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoB 762995 c.3189G>T synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>G synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoB 763034 c.3228C>G synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoB 763040 c.3234C>G synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoB 763070 c.3264T>C synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoB 763082 c.3276C>T synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoB 763088 c.3282C>G synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoB 763094 c.3288G>C synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoB 763115 c.3309T>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 763127 c.3321G>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoB 763136 c.3330C>T synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 763145 c.3339G>A synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoB 763157 c.3351G>T synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoB 763166 c.3360A>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 763172 c.3366G>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 763528 c.159G>A synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 763531 c.162G>T synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 763594 c.225C>T synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 763633 c.264T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 763657 c.288G>A synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 763660 c.291T>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 763666 c.297G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 763669 c.300C>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 763675 c.306C>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 763696 c.327T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 763699 c.330G>T synonymous_variant 0.24 rifampicin
rpoC 763702 c.333C>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 763708 c.339G>C synonymous_variant 0.26 rifampicin
rpoC 763711 c.342G>C synonymous_variant 0.26 rifampicin
rpoC 763714 c.345G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 763717 c.348T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 763723 c.354G>C synonymous_variant 0.27 rifampicin
rpoC 763732 c.363C>A synonymous_variant 0.3 rifampicin
rpoC 763741 c.372C>T synonymous_variant 0.32 rifampicin
rpoC 763744 c.375G>C synonymous_variant 0.3 rifampicin
rpoC 763747 c.378G>A synonymous_variant 0.3 rifampicin
rpoC 764377 c.1008C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 764380 c.1011G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 764387 c.1018T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764405 c.1036_1038delAGGinsCGC synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764428 c.1059G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 764431 c.1062G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 764434 c.1065A>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 764435 c.1066_1068delAGGinsCGA synonymous_variant 0.32 rifampicin
rpoC 764458 c.1089G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764461 c.1092A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764497 c.1128A>G synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 764510 c.1141C>T synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 764524 c.1155C>G synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 764530 c.1161C>G synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 764534 c.1165C>A synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 764539 c.1170C>T synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 764542 c.1173C>T synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 764545 c.1176C>A synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 764560 c.1191T>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 764575 c.1206T>G synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 764611 c.1242G>T synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 764626 c.1257C>T synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 764632 c.1263T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>T synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 764668 c.1299C>T synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 764692 c.1323C>T synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 764713 c.1344G>T synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 764716 c.1347G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 764746 c.1377G>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 764752 c.1383G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 764758 c.1389C>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 764764 c.1395T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764791 c.1422C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764803 c.1434C>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764809 c.1440C>T synonymous_variant 0.18 rifampicin Not assoc w R
rpoC 764810 p.Pro481Ala missense_variant 0.19 rifampicin Uncertain significance
rpoC 764815 c.1446A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764824 c.1455T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764827 c.1458G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 765019 c.1650A>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 765040 c.1671T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 765041 c.1672T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 765047 c.1678T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 765055 c.1686C>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 765421 c.2052C>G synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 765449 p.Ala694Ser missense_variant 0.35 rifampicin Uncertain significance
rpoC 765454 c.2085C>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 765469 c.2100G>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 765478 c.2109T>G synonymous_variant 0.32 rifampicin
rpoC 765480 p.Tyr704Phe missense_variant 0.32 rifampicin Uncertain significance
rpoC 765499 c.2130C>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 765517 c.2148C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 765875 p.Val836Ile missense_variant 0.25 rifampicin Uncertain significance
rpoC 765907 c.2538G>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 765910 c.2541G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 765928 c.2559C>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 765940 c.2571A>T synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 766963 c.3594T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 766996 c.3627C>T synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 767002 c.3633G>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 767008 c.3639G>A synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 767023 c.3654C>T synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 767044 c.3675G>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 767080 c.3711G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 767107 c.3738C>T synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 767119 c.3750A>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 767125 c.3756G>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 767134 c.3765C>T synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 767138 c.3769C>T synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 767149 c.3780C>T synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 767158 c.3789T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 767179 c.3810C>T synonymous_variant 0.23 rifampicin
rpoC 767180 p.Ala1271Ser missense_variant 0.23 rifampicin Uncertain significance
rpoC 767191 c.3822C>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 767197 c.3828G>A synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 767203 c.3834C>G synonymous_variant 0.27 rifampicin
rpoC 767206 c.3837C>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 767209 c.3840T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 767212 c.3843G>C synonymous_variant 0.26 rifampicin
rpoC 767221 c.3852C>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 767230 c.3861G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 767233 c.3864T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 767254 c.3885G>C synonymous_variant 0.13 rifampicin Not assoc w R - Interim
mmpL5 775639 p.Ile948Val missense_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781572 p.Gln5Asn missense_variant 0.43 streptomycin
rpsL 781586 c.27C>T synonymous_variant 0.5 streptomycin
rpsL 781595 c.36T>C synonymous_variant 0.57 streptomycin
rpsL 781608 p.Ser17Ala missense_variant 0.57 streptomycin
rpsL 781616 c.57C>G synonymous_variant 0.73 streptomycin
rpsL 781628 c.69T>C synonymous_variant 0.73 streptomycin Not assoc w R - Interim
rpsL 781649 c.90T>C synonymous_variant 0.6 streptomycin
rpsL 781655 c.96T>C synonymous_variant 0.6 streptomycin
rpsL 781658 c.99A>C synonymous_variant 0.53 streptomycin Not assoc w R - Interim
rpsL 781670 c.111G>C synonymous_variant 0.43 streptomycin
rpsL 781802 c.243G>C synonymous_variant 0.46 streptomycin
rpsL 781814 c.255C>T synonymous_variant 0.57 streptomycin
rpsL 781817 c.258G>T synonymous_variant 0.57 streptomycin
rpsL 781829 c.270G>C synonymous_variant 0.53 streptomycin
rpsL 781832 c.273T>C synonymous_variant 0.57 streptomycin
rpsL 781859 c.300T>C synonymous_variant 0.57 streptomycin Not assoc w R - Interim
rpsL 781868 c.309T>C synonymous_variant 0.47 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.47 streptomycin
rpsL 781877 c.318T>A synonymous_variant 0.5 streptomycin
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472106 n.261G>A non_coding_transcript_exon_variant 0.47 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.45 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472113 n.268T>C non_coding_transcript_exon_variant 0.44 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472137 n.292G>A non_coding_transcript_exon_variant 0.2 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472150 n.305T>A non_coding_transcript_exon_variant 0.68 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472151 n.306C>T non_coding_transcript_exon_variant 0.29 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472164 n.319G>A non_coding_transcript_exon_variant 0.29 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472172 n.327T>C non_coding_transcript_exon_variant 0.32 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472177 n.332C>T non_coding_transcript_exon_variant 0.33 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472203 n.358G>A non_coding_transcript_exon_variant 0.35 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472210 n.365A>C non_coding_transcript_exon_variant 0.34 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472213 n.368G>C non_coding_transcript_exon_variant 0.34 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472215 n.370A>G non_coding_transcript_exon_variant 0.34 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472225 n.380C>A non_coding_transcript_exon_variant 0.41 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472234 n.389T>C non_coding_transcript_exon_variant 0.33 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472236 n.391C>G non_coding_transcript_exon_variant 0.35 kanamycin
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472240 n.395G>A non_coding_transcript_exon_variant 0.36 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472251 n.406G>A non_coding_transcript_exon_variant 0.43 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472253 n.408G>T non_coding_transcript_exon_variant 0.29 kanamycin
capreomycin
streptomycin Uncertain significance
amikacin
rrs 1472446 n.601T>A non_coding_transcript_exon_variant 0.69 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472452 n.607G>A non_coding_transcript_exon_variant 0.75 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472464 n.619A>G non_coding_transcript_exon_variant 0.75 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472530 n.685G>A non_coding_transcript_exon_variant 0.49 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472541 n.696T>G non_coding_transcript_exon_variant 0.54 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472544 n.699C>A non_coding_transcript_exon_variant 0.55 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472545 n.700A>T non_coding_transcript_exon_variant 0.55 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472557 n.712G>A non_coding_transcript_exon_variant 0.57 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472570 n.725G>A non_coding_transcript_exon_variant 0.59 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472571 n.726G>C non_coding_transcript_exon_variant 0.59 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472573 n.728C>T non_coding_transcript_exon_variant 0.59 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472579 n.734G>T non_coding_transcript_exon_variant 0.61 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472581 n.736A>T non_coding_transcript_exon_variant 0.59 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472596 n.751G>T non_coding_transcript_exon_variant 0.56 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472598 n.753A>T non_coding_transcript_exon_variant 0.57 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472612 n.767G>T non_coding_transcript_exon_variant 0.34 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472614 n.769G>T non_coding_transcript_exon_variant 0.52 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472616 n.771G>A non_coding_transcript_exon_variant 0.52 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472713 n.868T>C non_coding_transcript_exon_variant 0.29 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472716 n.871C>T non_coding_transcript_exon_variant 0.3 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472734 n.889C>T non_coding_transcript_exon_variant 0.39 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472741 n.896G>A non_coding_transcript_exon_variant 0.4 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472742 n.897C>T non_coding_transcript_exon_variant 0.38 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472744 n.899A>G non_coding_transcript_exon_variant 0.38 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472767 n.922G>A non_coding_transcript_exon_variant 0.4 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472781 n.936C>T non_coding_transcript_exon_variant 0.36 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472793 n.948A>T non_coding_transcript_exon_variant 0.31 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472803 n.958T>A non_coding_transcript_exon_variant 0.27 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472846 n.1001C>T non_coding_transcript_exon_variant 0.48 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472847 n.1002G>A non_coding_transcript_exon_variant 0.48 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472848 n.1003T>C non_coding_transcript_exon_variant 0.5 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472860 n.1015C>T non_coding_transcript_exon_variant 0.56 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472861 n.1016G>A non_coding_transcript_exon_variant 0.59 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472956 n.1111T>C non_coding_transcript_exon_variant 0.48 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472957 n.1112C>T non_coding_transcript_exon_variant 0.48 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472969 n.1124A>G non_coding_transcript_exon_variant 0.52 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472970 n.1125C>G non_coding_transcript_exon_variant 0.52 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472977 n.1132G>C non_coding_transcript_exon_variant 0.57 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472978 n.1133T>C non_coding_transcript_exon_variant 0.57 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472989 n.1144G>A non_coding_transcript_exon_variant 0.64 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472990 n.1145A>G non_coding_transcript_exon_variant 0.64 kanamycin Not assoc w R
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1473082 n.1237G>A non_coding_transcript_exon_variant 0.79 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473088 n.1243A>G non_coding_transcript_exon_variant 0.71 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473099 n.1254T>A non_coding_transcript_exon_variant 0.6 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473104 n.1259C>T non_coding_transcript_exon_variant 0.53 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473105 n.1260G>A non_coding_transcript_exon_variant 0.53 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1473110 n.1265T>G non_coding_transcript_exon_variant 0.5 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473111 n.1266A>G non_coding_transcript_exon_variant 0.47 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473121 n.1276T>C non_coding_transcript_exon_variant 0.55 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1473123 n.1278A>T non_coding_transcript_exon_variant 0.55 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473129 n.1284C>T non_coding_transcript_exon_variant 0.55 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.57 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.59 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrl 1473829 n.172G>C non_coding_transcript_exon_variant 0.53 capreomycin Uncertain significance
linezolid
rrl 1473831 n.174G>T non_coding_transcript_exon_variant 0.53 capreomycin Uncertain significance
linezolid
rrl 1473832 n.175C>T non_coding_transcript_exon_variant 0.53 capreomycin Uncertain significance
linezolid
rrl 1473839 n.182G>A non_coding_transcript_exon_variant 0.53 capreomycin Uncertain significance
linezolid
rrl 1474496 n.839C>G non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid
rrl 1474497 n.840G>C non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474506 n.849C>G non_coding_transcript_exon_variant 0.48 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474507 n.850G>C non_coding_transcript_exon_variant 0.43 capreomycin Uncertain significance
linezolid
rrl 1474760 n.1103A>G non_coding_transcript_exon_variant 0.6 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474803 n.1146G>A non_coding_transcript_exon_variant 0.45 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474830 n.1173A>G non_coding_transcript_exon_variant 0.42 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475090 n.1433A>T non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475114 n.1457C>T non_coding_transcript_exon_variant 0.53 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475120 n.1463G>T non_coding_transcript_exon_variant 0.54 capreomycin Uncertain significance
linezolid
rrl 1475129 n.1472G>A non_coding_transcript_exon_variant 0.54 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476160 n.2503T>C non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476214 n.2557G>T non_coding_transcript_exon_variant 0.47 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476215 n.2558C>T non_coding_transcript_exon_variant 0.47 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476221 n.2564T>C non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.42 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476251 n.2594T>C non_coding_transcript_exon_variant 0.73 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476260 n.2603A>G non_coding_transcript_exon_variant 0.48 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476268 n.2611A>T non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid
rrl 1476275 n.2618T>A non_coding_transcript_exon_variant 0.48 capreomycin Uncertain significance
linezolid
rrl 1476279 n.2622G>A non_coding_transcript_exon_variant 0.48 capreomycin Uncertain significance
linezolid
rrl 1476280 n.2623A>C non_coding_transcript_exon_variant 0.48 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476293 n.2636C>T non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476294 n.2637A>G non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476295 n.2638C>G non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476296 n.2639C>T non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476297 n.2640C>T non_coding_transcript_exon_variant 0.62 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476301 n.2644A>C non_coding_transcript_exon_variant 0.42 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476302 n.2645G>A non_coding_transcript_exon_variant 0.42 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476311 n.2654G>C non_coding_transcript_exon_variant 0.45 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476312 n.2655T>C non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476313 n.2656G>A non_coding_transcript_exon_variant 0.45 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476332 n.2675G>C non_coding_transcript_exon_variant 0.62 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476353 n.2696G>T non_coding_transcript_exon_variant 0.73 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476358 n.2701T>C non_coding_transcript_exon_variant 0.76 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476369 n.2712C>T non_coding_transcript_exon_variant 0.76 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476372 n.2715T>C non_coding_transcript_exon_variant 0.76 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476382 n.2725A>G non_coding_transcript_exon_variant 0.77 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476383 n.2726T>A non_coding_transcript_exon_variant 0.77 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476408 n.2751G>A non_coding_transcript_exon_variant 0.84 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476425 n.2768G>T non_coding_transcript_exon_variant 0.83 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476428 n.2771C>T non_coding_transcript_exon_variant 0.84 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476429 n.2772A>C non_coding_transcript_exon_variant 0.83 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476454 n.2797C>T non_coding_transcript_exon_variant 0.13 capreomycin
linezolid
rrl 1476466 n.2809C>T non_coding_transcript_exon_variant 0.81 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476481 n.2824T>C non_coding_transcript_exon_variant 0.79 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476506 n.2849T>C non_coding_transcript_exon_variant 0.64 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476514 n.2857C>T non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476517 n.2860C>T non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid
rrl 1476519 n.2862C>G non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476524 n.2867C>A non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476525 n.2868A>G non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476530 n.2873C>T non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476536 n.2879G>A non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476537 n.2880A>G non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476538 n.2881A>G non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476540 n.2883C>G non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476547 n.2890C>T non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476567 n.2910C>T non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476572 n.2915G>A non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid
rrl 1476573 n.2916A>T non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.55 capreomycin Not assoc w R
linezolid Uncertain significance
rpsA 1833604 c.63C>T synonymous_variant 0.3 pyrazinamide
rpsA 1833616 c.75A>T synonymous_variant 0.33 pyrazinamide
rpsA 1833625 c.84A>G synonymous_variant 0.39 pyrazinamide
rpsA 1833664 c.123C>G synonymous_variant 0.35 pyrazinamide
rpsA 1833862 c.321G>T synonymous_variant 0.52 pyrazinamide
rpsA 1833874 c.333T>G synonymous_variant 0.5 pyrazinamide
rpsA 1833886 c.345C>G synonymous_variant 0.48 pyrazinamide
rpsA 1833894 p.Ala118Glu missense_variant 0.45 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.56 pyrazinamide
rpsA 1833949 c.408T>C synonymous_variant 0.5 pyrazinamide
rpsA 1833961 c.420C>G synonymous_variant 0.52 pyrazinamide
rpsA 1833970 c.429G>T synonymous_variant 0.5 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.52 pyrazinamide
rpsA 1833991 c.450C>G synonymous_variant 0.5 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.46 pyrazinamide
rpsA 1834009 c.468C>T synonymous_variant 0.43 pyrazinamide
rpsA 1834012 c.471G>C synonymous_variant 0.45 pyrazinamide
rpsA 1834015 c.474G>C synonymous_variant 0.45 pyrazinamide
rpsA 1834021 c.480C>T synonymous_variant 0.43 pyrazinamide
rpsA 1834030 c.489C>G synonymous_variant 0.38 pyrazinamide
rpsA 1834033 c.492C>T synonymous_variant 0.36 pyrazinamide
rpsA 1834327 c.786G>T synonymous_variant 0.37 pyrazinamide
rpsA 1834357 c.816T>C synonymous_variant 0.42 pyrazinamide
rpsA 1834366 c.825A>G synonymous_variant 0.44 pyrazinamide Not assoc w R - Interim
rpsA 1834375 c.834G>C synonymous_variant 0.48 pyrazinamide
rpsA 1834396 c.855G>C synonymous_variant 0.45 pyrazinamide
rpsA 1834411 c.870T>G synonymous_variant 0.47 pyrazinamide
rpsA 1834414 c.873C>T synonymous_variant 0.47 pyrazinamide
rpsA 1834417 c.876G>C synonymous_variant 0.47 pyrazinamide
rpsA 1834423 c.882G>C synonymous_variant 0.52 pyrazinamide
rpsA 1834429 c.888C>T synonymous_variant 0.55 pyrazinamide
rpsA 1834438 c.897C>T synonymous_variant 0.53 pyrazinamide Not assoc w R - Interim
rpsA 1834451 c.910T>C synonymous_variant 0.53 pyrazinamide
rpsA 1834456 c.915T>G synonymous_variant 0.52 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.42 pyrazinamide
rpsA 1834477 c.936C>T synonymous_variant 0.44 pyrazinamide Not assoc w R - Interim
rpsA 1834489 c.948T>C synonymous_variant 0.41 pyrazinamide
rpsA 1834606 c.1065C>T synonymous_variant 0.5 pyrazinamide
rpsA 1834609 c.1068T>C synonymous_variant 0.47 pyrazinamide
rpsA 1834619 c.1078T>C synonymous_variant 0.5 pyrazinamide
rpsA 1834622 c.1081_1083delTCGinsAGC synonymous_variant 0.5 pyrazinamide
rpsA 1834633 c.1092A>G synonymous_variant 0.56 pyrazinamide
rpsA 1834639 c.1098T>C synonymous_variant 0.53 pyrazinamide
rpsA 1834645 c.1104C>T synonymous_variant 0.58 pyrazinamide
rpsA 1834666 c.1125G>C synonymous_variant 0.57 pyrazinamide
rpsA 1834667 p.Ala376Ser missense_variant 0.57 pyrazinamide
rpsA 1834690 c.1149T>C synonymous_variant 0.5 pyrazinamide
rpsA 1834698 c.1157_1158insC frameshift_variant 0.48 pyrazinamide Uncertain significance
rpsA 1834701 p.Gln387Pro missense_variant 0.48 pyrazinamide
rpsA 1834704 c.1164delC frameshift_variant 0.48 pyrazinamide Uncertain significance
rpsA 1834720 c.1179C>G synonymous_variant 0.42 pyrazinamide
rpsA 1834732 c.1191T>C synonymous_variant 0.42 pyrazinamide
rpsA 1834738 c.1197A>G synonymous_variant 0.44 pyrazinamide
rpsA 1834753 c.1212T>C synonymous_variant 0.42 pyrazinamide
tsnR 1854077 p.Ser158Arg missense_variant 1.0 linezolid
tsnR 1854241 c.636C>G synonymous_variant 1.0 linezolid Not assoc w R - Interim
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
katG 2154915 c.1197A>G synonymous_variant 1.0 isoniazid Not assoc w R - Interim
PPE35 2169383 c.1230C>G synonymous_variant 0.81 pyrazinamide Not assoc w R - Interim
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
kasA 2517917 c.-198G>C upstream_gene_variant 0.33 isoniazid
kasA 2517941 c.-174C>G upstream_gene_variant 0.29 isoniazid
Rv2680 2995929 c.-176C>T upstream_gene_variant 1.0 capreomycin
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
mtrB 3625065 p.Met517Leu missense_variant 1.0 rifampicin Not assoc w R
bedaquiline Uncertain significance
mtrB 3625720 c.894G>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625729 c.885A>G synonymous_variant 0.44 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625732 c.882C>T synonymous_variant 0.44 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625735 c.879C>A synonymous_variant 0.47 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625744 c.870G>A synonymous_variant 0.5 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625750 c.864G>A synonymous_variant 0.5 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625755 p.Ala287Thr missense_variant 0.46 rifampicin Uncertain significance
bedaquiline
mtrB 3625761 p.Gln285Glu missense_variant 0.38 rifampicin Uncertain significance
bedaquiline
mtrB 3625762 c.852A>T synonymous_variant 0.38 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625765 c.849C>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625774 c.840G>A synonymous_variant 0.47 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3625783 c.-873C>T upstream_gene_variant 0.37 rifampicin
bedaquiline
mtrB 3626711 c.-98T>C upstream_gene_variant 0.5 rifampicin
bedaquiline
mtrB 3626717 c.-104C>T upstream_gene_variant 0.53 rifampicin
bedaquiline
mtrB 3626726 c.-113T>C upstream_gene_variant 0.55 rifampicin
bedaquiline
mtrB 3626732 c.-119A>G upstream_gene_variant 0.58 rifampicin
bedaquiline
mtrA 3626741 c.609C>G synonymous_variant 0.58 rifampicin Not assoc w R - Interim
bedaquiline
mtrA 3626756 c.594C>G synonymous_variant 0.67 rifampicin Not assoc w R - Interim
bedaquiline
mtrA 3626759 c.591T>C synonymous_variant 0.71 rifampicin Not assoc w R - Interim
bedaquiline
mtrA 3626762 c.588G>C synonymous_variant 0.71 rifampicin Not assoc w R - Interim
bedaquiline
mtrA 3626786 c.564A>G synonymous_variant 0.64 rifampicin Not assoc w R - Interim
bedaquiline
mtrA 3626792 c.558G>T synonymous_variant 0.62 rifampicin Not assoc w R - Interim
bedaquiline
mtrA 3626804 c.546A>G synonymous_variant 0.59 rifampicin Not assoc w R - Interim
bedaquiline
mtrA 3626825 c.525T>A synonymous_variant 0.61 rifampicin Not assoc w R - Interim
bedaquiline
mtrA 3626846 c.504G>A synonymous_variant 0.44 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626852 c.-239G>A upstream_gene_variant 0.44 rifampicin
bedaquiline
mtrB 3626857 c.-244T>C upstream_gene_variant 0.44 rifampicin
bedaquiline
mtrB 3626858 c.-245A>G upstream_gene_variant 0.44 rifampicin
bedaquiline
mtrB 3626861 c.-248C>G upstream_gene_variant 0.44 rifampicin
bedaquiline
mtrB 3626866 c.-253T>C upstream_gene_variant 0.44 rifampicin
bedaquiline
fbiA 3640308 c.-235C>T upstream_gene_variant 1.0 pretomanid
delamanid
clofazimine
rpoA 3877587 c.921A>G synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoA 3877593 c.915C>T synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoA 3877614 c.894G>A synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoA 3877620 c.888G>A synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoA 3877638 c.870T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoA 3877782 c.726T>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoA 3877797 c.711G>A synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoA 3877839 c.669G>A synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoA 3877848 c.660C>T synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoA 3877856 c.652T>C synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoA 3877875 c.633T>C synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoA 3877896 c.612G>A synonymous_variant 0.65 rifampicin
rpoA 3877905 c.603A>G synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoA 3877908 c.600T>C synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoA 3877920 c.588G>C synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoA 3877923 c.585C>T synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoA 3877929 p.Ile193Val missense_variant 0.55 rifampicin Uncertain significance
rpoA 3877962 c.546G>T synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoA 3877971 p.Asp179Glu missense_variant 0.41 rifampicin Uncertain significance
rpoA 3877974 c.534G>T synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoA 3877977 p.Lys177Asn missense_variant 0.35 rifampicin Uncertain significance
rpoA 3877989 c.519A>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoA 3878160 c.348C>G synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoA 3878163 c.345C>T synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoA 3878169 c.339G>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoA 3878184 c.324C>T synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoA 3878193 c.315T>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoA 3878196 p.Glu104Ala missense_variant 0.52 rifampicin Uncertain significance
rpoA 3878205 c.303T>C synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoA 3878217 c.291A>G synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoA 3878259 c.249G>C synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoA 3878271 c.237T>C synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoA 3878283 p.Glu75Asp missense_variant 0.62 rifampicin Uncertain significance
rpoA 3878292 c.216T>C synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoA 3878298 c.210A>G synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoA 3878310 c.198G>T synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoA 3878313 c.195G>C synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoA 3878322 c.186A>G synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoA 3878331 c.177A>G synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoA 3878337 c.171T>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoA 3878343 c.165C>T synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoA 3878346 c.162T>C synonymous_variant 0.47 rifampicin
rpoA 3878364 c.144A>C synonymous_variant 0.44 rifampicin
rpoA 3878367 c.141C>G synonymous_variant 0.44 rifampicin
rpoA 3878370 c.138T>C synonymous_variant 0.47 rifampicin
rpoA 3878373 c.135G>C synonymous_variant 0.47 rifampicin
rpoA 3878381 c.127C>T synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoA 3878391 c.117T>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoA 3878400 c.108T>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
clpC1 4039454 c.1251A>G synonymous_variant 0.13 pyrazinamide Not assoc w R - Interim
clpC1 4039466 c.1239T>C synonymous_variant 0.13 pyrazinamide
clpC1 4039469 c.1236T>C synonymous_variant 0.14 pyrazinamide
clpC1 4039472 c.1233G>C synonymous_variant 0.14 pyrazinamide
clpC1 4039478 c.1227G>C synonymous_variant 0.14 pyrazinamide
clpC1 4039481 c.1224T>C synonymous_variant 0.14 pyrazinamide
clpC1 4039487 c.1218G>C synonymous_variant 0.15 pyrazinamide
clpC1 4039522 c.1183C>T synonymous_variant 0.17 pyrazinamide
clpC1 4039528 c.1177C>A synonymous_variant 0.16 pyrazinamide
clpC1 4039541 c.1164C>G synonymous_variant 0.15 pyrazinamide
clpC1 4039544 c.1161C>T synonymous_variant 0.14 pyrazinamide
clpC1 4039559 c.1146C>G synonymous_variant 0.14 pyrazinamide
clpC1 4039565 c.1140G>T synonymous_variant 0.13 pyrazinamide
clpC1 4039649 c.1056G>C synonymous_variant 0.11 pyrazinamide
clpC1 4039682 c.1023C>G synonymous_variant 0.12 pyrazinamide
clpC1 4039694 c.1011G>C synonymous_variant 0.12 pyrazinamide
clpC1 4039724 c.981A>G synonymous_variant 0.12 pyrazinamide
clpC1 4040480 c.225T>C synonymous_variant 0.11 pyrazinamide Not assoc w R - Interim
clpC1 4040522 c.183T>C synonymous_variant 0.15 pyrazinamide Not assoc w R - Interim
clpC1 4040531 c.174T>G synonymous_variant 0.16 pyrazinamide
clpC1 4040546 c.159G>C synonymous_variant 0.14 pyrazinamide
clpC1 4040558 c.147G>C synonymous_variant 0.12 pyrazinamide
clpC1 4040561 c.144A>G synonymous_variant 0.13 pyrazinamide
clpC1 4040573 c.132T>C synonymous_variant 0.13 pyrazinamide Not assoc w R - Interim
clpC1 4040579 c.126A>G synonymous_variant 0.13 pyrazinamide
clpC1 4040582 c.123G>C synonymous_variant 0.13 pyrazinamide Not assoc w R - Interim
clpC1 4040585 c.120A>G synonymous_variant 0.13 pyrazinamide
embC 4240789 c.927T>C synonymous_variant 0.44 ethambutol
embC 4240819 c.957A>C synonymous_variant 0.5 ethambutol
embC 4240826 p.Ala322Ser missense_variant 0.52 ethambutol
embC 4240831 c.969T>G synonymous_variant 0.48 ethambutol
embC 4240856 p.Ala332Thr missense_variant 0.42 ethambutol
embC 4240859 p.Leu333Ile missense_variant 0.42 ethambutol
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 kanamycin
capreomycin
amikacin
gid 4408358 c.-156C>G upstream_gene_variant 1.0 streptomycin