TB-Profiler result

Run: ERR4817998
Summary

Run ID: ERR4817998

Sample name:

Date: 2024-04-16T09:56:10.043829

Number of reads: 3041318

Percentage reads mapped: 74.14

Median coverage: 64.0

Strain: lineage3

Spoligotype:

Drug-resistance: Other

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage3 East-African-Indian RD750 1.0
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol
pyrazinamide
streptomycin rrs n.888G>A Uncertain significance Mutation from literature
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
rrs 1472733 n.888G>A non_coding_transcript_exon_variant 0.48 streptomycin Uncertain significance Mutation from literature
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
gyrA 6673 c.-629A>C upstream_gene_variant 0.17 levofloxacin
moxifloxacin
gyrA 6676 c.-626T>G upstream_gene_variant 0.16 levofloxacin
moxifloxacin
gyrA 7129 c.-173T>G upstream_gene_variant 0.16 levofloxacin
moxifloxacin
gyrA 7136 c.-166T>C upstream_gene_variant 0.21 levofloxacin
moxifloxacin
gyrA 7144 c.-158A>G upstream_gene_variant 0.26 levofloxacin
moxifloxacin
gyrA 7150 c.-152G>A upstream_gene_variant 0.28 levofloxacin
moxifloxacin
gyrB 7153 c.1914G>C synonymous_variant 0.29 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 7159 c.1920C>T synonymous_variant 0.3 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7162 c.-140C>G upstream_gene_variant 0.29 levofloxacin
moxifloxacin
gyrA 7168 c.-134C>G upstream_gene_variant 0.32 levofloxacin
moxifloxacin
gyrA 7178 c.-124T>C upstream_gene_variant 0.27 levofloxacin
moxifloxacin
gyrA 7355 c.54T>A synonymous_variant 0.14 levofloxacin
moxifloxacin
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7391 c.90C>T synonymous_variant 0.14 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7394 c.93T>C synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7397 c.96G>C synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 7406 c.105G>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 7412 c.111C>G synonymous_variant 0.14 levofloxacin
moxifloxacin
gyrA 7421 c.120G>T synonymous_variant 0.14 levofloxacin
moxifloxacin
gyrA 7439 c.138C>T synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 7457 c.156T>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 7463 c.162G>C synonymous_variant 0.14 levofloxacin
moxifloxacin
gyrA 7466 c.165G>C synonymous_variant 0.12 levofloxacin
moxifloxacin
gyrA 7472 c.171T>C synonymous_variant 0.11 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7475 c.174A>G synonymous_variant 0.12 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7480 p.Phe60Tyr missense_variant 0.18 levofloxacin
moxifloxacin
gyrA 7484 c.183T>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 7490 c.189C>G synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 7496 c.195C>G synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7499 c.198G>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 7523 c.222C>G synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7526 c.225G>C synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7532 c.231T>G synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7547 c.246C>T synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7559 c.258G>A synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 7571 c.270G>C synonymous_variant 0.25 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7574 c.273G>C synonymous_variant 0.25 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7601 c.300C>G synonymous_variant 0.14 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8897 c.1596T>C synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8915 c.1614A>G synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8924 c.1623C>T synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8945 c.1644G>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8946 c.1645_1647delTTGinsCC frameshift_variant&missense_variant 0.17 levofloxacin
moxifloxacin
gyrA 8967 p.Ala556Lys missense_variant 0.2 levofloxacin
moxifloxacin
gyrA 8987 c.1686C>G synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8990 c.1689C>G synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8993 c.1692C>T synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8996 c.1695T>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8998 p.Leu566Trp missense_variant 0.19 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9018 p.Gln573Lys missense_variant 0.18 levofloxacin
moxifloxacin
gyrA 9023 c.1722A>T synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 9026 c.1725G>C synonymous_variant 0.13 levofloxacin
moxifloxacin
gyrA 9044 c.1743C>G synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
fgd1 491742 c.960T>C synonymous_variant 1.0 clofazimine Not assoc w R
pretomanid
delamanid Not assoc w R - Interim
Rv0565c 657081 c.390G>A synonymous_variant 1.0 ethionamide Not assoc w R - Interim
hadA 731738 c.-192G>C upstream_gene_variant 0.12 isoniazid
hadA 731742 c.-188A>G upstream_gene_variant 0.12 isoniazid
hadA 731747 c.-183T>C upstream_gene_variant 0.13 isoniazid
hadA 731756 c.-174C>T upstream_gene_variant 0.14 isoniazid
hadA 731760 c.-170_-169delGTinsAC upstream_gene_variant 0.14 isoniazid
hadA 731789 c.-141A>G upstream_gene_variant 0.16 isoniazid
hadA 731798 c.-132C>G upstream_gene_variant 0.18 isoniazid
hadA 731801 c.-129C>T upstream_gene_variant 0.18 isoniazid
hadA 731810 c.-120G>T upstream_gene_variant 0.18 isoniazid
hadA 731822 c.-108G>A upstream_gene_variant 0.12 isoniazid
nusG 734415 c.162C>G synonymous_variant 0.15 rifampicin
nusG 734421 c.168A>C synonymous_variant 0.16 rifampicin
nusG 734424 c.171G>T synonymous_variant 0.22 rifampicin
nusG 734445 c.192C>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
nusG 734452 c.199_201delGAAinsCG frameshift_variant&missense_variant 0.29 rifampicin
nusG 734460 c.207G>T synonymous_variant 0.31 rifampicin Not assoc w R - Interim
nusG 734472 c.219T>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
nusG 734475 c.222T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
nusG 734497 c.244_246delGTGinsAC frameshift_variant&missense_variant 0.33 rifampicin
nusG 734532 c.279A>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
nusG 734541 c.288A>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
nusG 734544 c.291C>T synonymous_variant 0.33 rifampicin
rpoB 759746 c.-61C>T upstream_gene_variant 1.0 rifampicin Not assoc w R
rpoB 760184 c.378A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760196 c.390C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760223 c.417T>C synonymous_variant 0.2 rifampicin
rpoB 760235 c.429T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 760244 c.438G>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 760430 c.624T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 760433 c.627C>T synonymous_variant 0.31 rifampicin
rpoB 760454 c.648C>G synonymous_variant 0.26 rifampicin
rpoB 760457 c.651C>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760469 c.663C>T synonymous_variant 0.21 rifampicin
rpoB 760475 c.669A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 760478 c.672C>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760646 c.840C>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760655 c.849A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760661 c.855A>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760668 c.862_864delACGinsGC frameshift_variant&missense_variant 0.14 rifampicin
rpoB 760674 c.868T>C synonymous_variant 0.12 rifampicin Not assoc w R - Interim
rpoB 760683 c.877T>C synonymous_variant 0.12 rifampicin Not assoc w R - Interim
rpoB 760862 c.1056G>C synonymous_variant 0.11 rifampicin Not assoc w R - Interim
rpoB 760869 p.Val355Leu missense_variant 0.12 rifampicin
rpoB 760910 c.1104C>T synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 760916 c.1110C>T synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 761084 c.1278C>A synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 761097 c.1291_1293delAGCinsTCG synonymous_variant 0.13 rifampicin
rpoB 761102 c.1296A>G synonymous_variant 0.12 rifampicin
rpoB 761147 c.1341C>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 761150 c.1344A>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 761165 c.1359G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761171 c.1365C>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761178 c.1372_1374delTCAinsAC frameshift_variant&missense_variant 0.16 rifampicin
rpoB 761186 p.Glu460Asp missense_variant 0.16 rifampicin Uncertain significance
rpoB 761189 c.1383T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761195 c.1389G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 761198 c.1392G>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761219 c.1413G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761234 c.1428G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 761249 c.1443A>G synonymous_variant 0.12 rifampicin Not assoc w R - Interim
rpoB 761255 c.1449T>G synonymous_variant 0.11 rifampicin Not assoc w R - Interim
rpoB 761555 c.1749G>C synonymous_variant 0.11 rifampicin Not assoc w R - Interim
rpoB 761558 c.1752C>G synonymous_variant 0.11 rifampicin Not assoc w R - Interim
rpoB 761570 c.1764T>C synonymous_variant 0.12 rifampicin Not assoc w R - Interim
rpoB 761573 c.1767C>G synonymous_variant 0.12 rifampicin Not assoc w R - Interim
rpoB 761579 c.1773G>C synonymous_variant 0.12 rifampicin Not assoc w R - Interim
rpoB 761612 c.1806G>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 761615 c.1809A>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 761636 c.1830G>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 761645 c.1839C>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 761648 c.1842T>C synonymous_variant 0.17 rifampicin
rpoB 761666 c.1860G>C synonymous_variant 0.14 rifampicin
rpoB 761669 c.1863C>T synonymous_variant 0.15 rifampicin
rpoB 761675 c.1869G>T synonymous_variant 0.16 rifampicin
rpoB 761687 c.1881C>T synonymous_variant 0.16 rifampicin
rpoB 761690 c.1884G>C synonymous_variant 0.13 rifampicin
rpoB 761693 c.1887G>C synonymous_variant 0.14 rifampicin
rpoB 761750 c.1944G>C synonymous_variant 0.12 rifampicin
rpoB 761760 p.Ile652Val missense_variant 0.12 rifampicin
rpoB 762167 c.2361T>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 762233 c.2427G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 762236 c.2430G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 762245 c.2439G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 762284 c.2478G>T synonymous_variant 0.2 rifampicin
rpoB 762293 c.2487T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 762296 c.2490G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 762299 c.2493G>C synonymous_variant 0.21 rifampicin
rpoB 762317 c.2511A>G synonymous_variant 0.12 rifampicin Not assoc w R - Interim
rpoB 762434 c.2628T>G synonymous_variant 0.91 rifampicin Not assoc w R
rpoC 762509 c.-861T>G upstream_gene_variant 0.13 rifampicin
rpoB 762510 p.Ala902Pro missense_variant 0.13 rifampicin Uncertain significance
rpoB 762515 c.2709C>T synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 762879 p.Met1025Leu missense_variant 0.18 rifampicin Uncertain significance
rpoB 762894 c.3088C>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 762899 c.3093G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 762911 c.-459C>T upstream_gene_variant 0.19 rifampicin
rpoB 762917 c.3111C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 762920 c.3114C>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 762923 c.3117C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 762959 c.3153G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 762962 c.3156C>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 762983 c.-387C>T upstream_gene_variant 0.16 rifampicin
rpoB 762989 c.3183G>A synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 762995 c.3189G>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>C synonymous_variant 0.77 rifampicin Not assoc w R
rpoB 763031 c.3225T>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 763034 c.-336C>A upstream_gene_variant 0.24 rifampicin
rpoB 763040 c.3234C>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 763070 c.3264T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 763076 c.-294C>A upstream_gene_variant 0.23 rifampicin
rpoB 763082 c.3276C>T synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 763088 c.3282C>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 763094 c.3288G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 763115 c.3309T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 763127 c.3321G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 763136 c.3330C>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 763142 c.-228C>G upstream_gene_variant 0.14 rifampicin
rpoB 763157 c.3351G>T synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoC 763528 c.159G>A synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 763531 c.162G>T synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 763594 c.225C>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 763618 c.249C>T synonymous_variant 0.16 rifampicin
rpoC 763633 c.264T>C synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoC 763660 c.291T>G synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 763666 c.297G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 763669 c.300C>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 763675 c.306C>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 763699 c.330G>T synonymous_variant 0.17 rifampicin
rpoC 763702 c.333C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 763708 c.339G>T synonymous_variant 0.16 rifampicin
rpoC 763711 c.342G>C synonymous_variant 0.16 rifampicin
rpoC 763714 c.345G>A synonymous_variant 0.15 rifampicin
rpoC 763717 c.348T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 763723 c.354G>C synonymous_variant 0.14 rifampicin
rpoC 763732 c.363C>G synonymous_variant 0.15 rifampicin
rpoC 764353 c.984G>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764365 c.996C>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764371 c.1002G>T synonymous_variant 0.22 rifampicin
rpoC 764377 c.1008C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764380 c.1011G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764387 c.1018T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764392 c.1023C>T synonymous_variant 0.23 rifampicin
rpoC 764405 c.1036_1038delAGGinsCC frameshift_variant&missense_variant 0.22 rifampicin
rpoC 764428 c.1059G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764431 c.1062G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 764434 c.1065A>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 764435 c.1066_1068delAGGinsCA frameshift_variant&missense_variant 0.15 rifampicin
rpoC 764461 c.1092A>G synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoC 764578 c.1209C>G synonymous_variant 0.12 rifampicin
rpoC 764626 c.1257C>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764632 c.1263T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 764635 c.1266C>T synonymous_variant 0.25 rifampicin
rpoC 764650 c.1281G>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 764713 c.1344G>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 764746 c.1377G>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764752 c.1383G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764758 c.1389C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764764 c.1395T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764803 c.1434C>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764810 c.1441_1443delCCCinsGT frameshift_variant&missense_variant 0.2 rifampicin
rpoC 764815 c.1446A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 764827 c.1458G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764858 c.1489T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 764869 c.1500C>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764875 c.1506C>A synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 764878 c.1509C>G synonymous_variant 0.25 rifampicin
rpoC 764887 c.1518G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 764888 c.1519T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 764911 c.1542A>G synonymous_variant 0.24 rifampicin
rpoC 764912 p.Met515Gln missense_variant 0.24 rifampicin Uncertain significance
rpoC 764932 c.1563C>A synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 764948 c.1579T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764968 c.1599T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 765047 c.1678T>C synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoC 765055 c.1686C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 765073 c.1704G>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 765076 c.1707A>G synonymous_variant 0.13 rifampicin
rpoC 765079 c.1710T>G synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoC 765082 c.1713G>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 765085 c.1716T>C synonymous_variant 0.14 rifampicin
rpoC 765089 c.1720T>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 765103 c.1734G>T synonymous_variant 0.14 rifampicin
rpoC 765394 c.2025G>A synonymous_variant 0.15 rifampicin
rpoC 765403 c.2034G>C synonymous_variant 0.14 rifampicin
rpoC 765405 p.Leu679His missense_variant 0.14 rifampicin Uncertain significance
rpoC 765409 c.2040T>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 765412 c.2043T>C synonymous_variant 0.16 rifampicin
rpoC 765421 c.2052C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 765449 c.2080_2082delGCCinsTG frameshift_variant&missense_variant 0.17 rifampicin
rpoC 765454 c.2085C>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 765469 c.2100G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 765478 c.2109T>G synonymous_variant 0.12 rifampicin
rpoC 765480 p.Tyr704Phe missense_variant 0.12 rifampicin Uncertain significance
rpoC 765496 c.2127C>T synonymous_variant 0.13 rifampicin
rpoC 765499 c.2130C>G synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoC 765871 c.2502T>G synonymous_variant 0.12 rifampicin Not assoc w R - Interim
rpoC 765886 c.2517C>G synonymous_variant 0.12 rifampicin
rpoC 766618 c.3249G>T synonymous_variant 0.11 rifampicin
rpoC 766624 c.3255G>C synonymous_variant 0.11 rifampicin
rpoC 766630 c.3261G>C synonymous_variant 0.11 rifampicin
rpoC 766996 c.3627C>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 767002 c.3633G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 767008 c.3639G>A synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 767044 c.3675G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 767080 c.3711G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 767098 c.3729T>C synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoC 767100 p.Lys1244Arg missense_variant 0.13 rifampicin
rpoC 767107 c.3738C>T synonymous_variant 0.12 rifampicin Not assoc w R - Interim
mmpL5 775639 p.Ile948Val missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
mmpL5 776100 p.Thr794Ile missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781817 c.258G>T synonymous_variant 0.16 streptomycin
rpsL 781829 c.270G>C synonymous_variant 0.17 streptomycin
rpsL 781832 c.273T>C synonymous_variant 0.17 streptomycin
rpsL 781859 c.300T>C synonymous_variant 0.15 streptomycin Not assoc w R - Interim
rpsL 781868 c.309T>C synonymous_variant 0.13 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.14 streptomycin
rpsL 781877 c.318T>A synonymous_variant 0.14 streptomycin
rplC 800672 c.-137G>C upstream_gene_variant 0.12 linezolid
rplC 800693 c.-116A>C upstream_gene_variant 0.15 linezolid
rplC 800703 c.-106_-104delTTGinsCC upstream_gene_variant 0.15 linezolid
rplC 800715 c.-94A>C upstream_gene_variant 0.14 linezolid
rplC 800720 c.-89T>C upstream_gene_variant 0.14 linezolid
rplC 800723 c.-86C>G upstream_gene_variant 0.12 linezolid
rplC 800735 c.-74C>G upstream_gene_variant 0.12 linezolid
Rv1129c 1254562 c.-28T>C upstream_gene_variant 1.0 moxifloxacin Not assoc w R
levofloxacin Not assoc w R
rifampicin Not assoc w R
isoniazid Not assoc w R
Rv1258c 1407274 p.Asp23Asn missense_variant 1.0 streptomycin
isoniazid
pyrazinamide
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471922 n.78delT non_coding_transcript_exon_variant 0.31 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471925 n.80T>C non_coding_transcript_exon_variant 0.31 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471931 n.87delA non_coding_transcript_exon_variant 0.3 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471934 n.89A>G non_coding_transcript_exon_variant 0.3 streptomycin Uncertain significance
kanamycin
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472150 n.305T>A non_coding_transcript_exon_variant 0.59 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472251 n.406G>A non_coding_transcript_exon_variant 0.67 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472713 n.868T>C non_coding_transcript_exon_variant 0.45 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472716 n.871C>T non_coding_transcript_exon_variant 0.45 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472742 n.897C>T non_coding_transcript_exon_variant 0.46 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472744 n.899A>G non_coding_transcript_exon_variant 0.46 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472781 n.936C>T non_coding_transcript_exon_variant 0.48 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472790 n.945T>C non_coding_transcript_exon_variant 0.47 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472977 n.1132G>C non_coding_transcript_exon_variant 0.54 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472978 n.1133T>C non_coding_transcript_exon_variant 0.5 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472989 n.1144G>A non_coding_transcript_exon_variant 0.79 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472990 n.1145A>G non_coding_transcript_exon_variant 0.93 streptomycin Uncertain significance
kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1473035 n.1190G>A non_coding_transcript_exon_variant 0.67 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1473055 n.1210C>T non_coding_transcript_exon_variant 0.63 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473056 n.1211A>T non_coding_transcript_exon_variant 0.63 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1473066 n.1221A>G non_coding_transcript_exon_variant 0.62 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.86 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.91 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrl 1475760 n.2105_2106delGC non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1475764 n.2107A>T non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1475765 n.2108A>T non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1476381 n.2724G>C non_coding_transcript_exon_variant 0.58 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476428 n.2771C>T non_coding_transcript_exon_variant 0.61 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476429 n.2772A>C non_coding_transcript_exon_variant 0.56 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476466 n.2809C>T non_coding_transcript_exon_variant 0.47 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.39 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476594 n.2937C>T non_coding_transcript_exon_variant 0.41 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476597 n.2940G>A non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid
rpsA 1833589 c.48A>C synonymous_variant 0.12 pyrazinamide
rpsA 1833595 c.54T>G synonymous_variant 0.12 pyrazinamide
rpsA 1833596 p.Ser19Ala missense_variant 0.12 pyrazinamide
rpsA 1833604 c.63C>T synonymous_variant 0.13 pyrazinamide
rpsA 1833709 c.168C>T synonymous_variant 0.24 pyrazinamide
rpsA 1833724 c.183C>T synonymous_variant 0.18 pyrazinamide
rpsA 1833727 c.186G>C synonymous_variant 0.18 pyrazinamide
rpsA 1833733 c.192C>G synonymous_variant 0.18 pyrazinamide
rpsA 1833734 p.Ala65Ser missense_variant 0.18 pyrazinamide
rpsA 1833748 c.207C>G synonymous_variant 0.2 pyrazinamide
rpsA 1833751 c.210C>T synonymous_variant 0.22 pyrazinamide Not assoc w R - Interim
rpsA 1833760 c.219C>T synonymous_variant 0.22 pyrazinamide Not assoc w R - Interim
rpsA 1833787 c.246C>G synonymous_variant 0.26 pyrazinamide
rpsA 1833790 c.249T>C synonymous_variant 0.26 pyrazinamide
rpsA 1833802 c.261A>G synonymous_variant 0.19 pyrazinamide
rpsA 1833829 c.288A>G synonymous_variant 0.25 pyrazinamide
rpsA 1833832 c.291G>A synonymous_variant 0.27 pyrazinamide
rpsA 1833838 c.297G>T synonymous_variant 0.25 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.27 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.33 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.31 pyrazinamide
rpsA 1833862 c.321G>T synonymous_variant 0.32 pyrazinamide
rpsA 1833874 c.333T>G synonymous_variant 0.28 pyrazinamide
rpsA 1833886 c.345C>G synonymous_variant 0.26 pyrazinamide
rpsA 1833892 c.351G>A synonymous_variant 0.26 pyrazinamide
rpsA 1833894 p.Ala118Glu missense_variant 0.27 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.22 pyrazinamide
rpsA 1833949 c.408T>C synonymous_variant 0.16 pyrazinamide
rpsA 1833970 c.429G>C synonymous_variant 0.17 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.16 pyrazinamide
rpsA 1833991 c.450C>G synonymous_variant 0.17 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.25 pyrazinamide
rpsA 1834009 c.468C>T synonymous_variant 0.25 pyrazinamide
rpsA 1834012 c.471G>T synonymous_variant 0.25 pyrazinamide
rpsA 1834015 c.474G>C synonymous_variant 0.25 pyrazinamide
rpsA 1834021 c.480C>T synonymous_variant 0.26 pyrazinamide
rpsA 1834030 c.489C>G synonymous_variant 0.28 pyrazinamide
rpsA 1834069 c.528G>C synonymous_variant 0.3 pyrazinamide
rpsA 1834073 p.Lys178Arg missense_variant 0.29 pyrazinamide
rpsA 1834097 c.556_557delTCinsAG synonymous_variant 0.18 pyrazinamide
rpsA 1834228 c.687C>A synonymous_variant 0.2 pyrazinamide
rpsA 1834231 c.690T>G synonymous_variant 0.19 pyrazinamide
rpsA 1834234 c.693G>T synonymous_variant 0.21 pyrazinamide Not assoc w R - Interim
rpsA 1834240 c.699T>C synonymous_variant 0.21 pyrazinamide
rpsA 1834246 c.705G>T synonymous_variant 0.22 pyrazinamide
rpsA 1834249 c.708T>C synonymous_variant 0.23 pyrazinamide
rpsA 1834252 c.711C>G synonymous_variant 0.21 pyrazinamide
rpsA 1834261 c.720A>G synonymous_variant 0.23 pyrazinamide Not assoc w R - Interim
rpsA 1834264 c.723G>C synonymous_variant 0.24 pyrazinamide
rpsA 1834297 c.756C>T synonymous_variant 0.25 pyrazinamide
rpsA 1834303 c.762T>G synonymous_variant 0.24 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.19 pyrazinamide
rpsA 1834339 c.798C>T synonymous_variant 0.19 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
rpsA 1834366 c.825A>G synonymous_variant 0.15 pyrazinamide Not assoc w R - Interim
rpsA 1834375 c.834G>A synonymous_variant 0.16 pyrazinamide
rpsA 1834378 c.837T>C synonymous_variant 0.16 pyrazinamide Not assoc w R - Interim
rpsA 1834520 p.Ala327Ser missense_variant 0.16 pyrazinamide
rpsA 1834528 c.987T>C synonymous_variant 0.17 pyrazinamide
rpsA 1834543 c.1002C>G synonymous_variant 0.14 pyrazinamide
rpsA 1834555 c.1014T>G synonymous_variant 0.13 pyrazinamide
rpsA 1834557 p.Ala339Gly missense_variant 0.11 pyrazinamide
tsnR 1853604 c.-2C>T upstream_gene_variant 1.0 linezolid Uncertain significance
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
katG 2154724 p.Arg463Leu missense_variant 1.0 isoniazid Not assoc w R
PPE35 2167926 p.Leu896Ser missense_variant 0.97 pyrazinamide Not assoc w R
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
pncA 2289047 c.195C>T synonymous_variant 1.0 pyrazinamide Not assoc w R
pncA 2289365 c.-125delC upstream_gene_variant 1.0 pyrazinamide
ahpC 2726105 c.-88G>A upstream_gene_variant 1.0 isoniazid Not assoc w R
Rv2477c 2782498 c.1545C>T synonymous_variant 1.0 ethambutol Not assoc w R
moxifloxacin Not assoc w R
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R
kanamycin Not assoc w R
rifampicin Not assoc w R
amikacin Not assoc w R
Rv2477c 2783302 c.741A>G synonymous_variant 0.12 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783311 c.732T>C synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783317 c.726G>C synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783341 c.702C>G synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783350 c.693T>C synonymous_variant 0.15 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783353 c.690T>C synonymous_variant 0.14 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783356 c.687C>G synonymous_variant 0.14 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783362 c.681G>C synonymous_variant 0.13 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783371 c.672A>G synonymous_variant 0.12 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783374 c.669G>C synonymous_variant 0.12 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783377 c.666C>G synonymous_variant 0.13 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2752c 3066745 c.-554C>A upstream_gene_variant 1.0 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
mtrB 3625065 p.Met517Leu missense_variant 0.98 bedaquiline Uncertain significance
rifampicin Not assoc w R
mtrA 3627068 c.282T>C synonymous_variant 0.17 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627071 c.-458G>C upstream_gene_variant 0.19 bedaquiline
rifampicin
mtrB 3627083 c.-470G>C upstream_gene_variant 0.17 bedaquiline
rifampicin
mtrA 3627098 c.252A>C synonymous_variant 0.15 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627104 c.-491C>G upstream_gene_variant 0.16 bedaquiline
rifampicin
mtrB 3627110 c.-497G>C upstream_gene_variant 0.17 bedaquiline
rifampicin
mtrA 3627119 c.231T>G synonymous_variant 0.14 bedaquiline
rifampicin Not assoc w R - Interim
alr 3841473 c.-53G>A upstream_gene_variant 1.0 cycloserine
rpoA 3877656 c.852T>G synonymous_variant 0.11 rifampicin Not assoc w R - Interim
rpoA 3877818 c.690A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoA 3877839 c.669G>T synonymous_variant 0.18 rifampicin
rpoA 3877848 c.660C>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoA 3877856 c.652T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoA 3877860 c.648C>T synonymous_variant 0.16 rifampicin
rpoA 3877875 c.633T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3877881 c.627G>C synonymous_variant 0.18 rifampicin
rpoA 3877887 c.621G>C synonymous_variant 0.15 rifampicin
rpoA 3877893 c.615C>T synonymous_variant 0.12 rifampicin Not assoc w R - Interim
rpoA 3877900 p.Ser203Thr missense_variant 0.14 rifampicin
rpoA 3877905 c.603A>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoA 3877908 c.600T>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoA 3878070 c.438T>C synonymous_variant 0.15 rifampicin
rpoA 3878079 c.429C>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoA 3878082 c.426T>C synonymous_variant 0.16 rifampicin
rpoA 3878102 p.Val136Ile missense_variant 0.17 rifampicin
rpoA 3878103 c.405A>G synonymous_variant 0.17 rifampicin
rpoA 3878118 c.390T>C synonymous_variant 0.17 rifampicin
rpoA 3878127 c.381G>C synonymous_variant 0.16 rifampicin
rpoA 3878130 c.378C>G synonymous_variant 0.18 rifampicin
rpoA 3878143 p.Gly122Asp missense_variant 0.21 rifampicin Uncertain significance
rpoA 3878160 c.348C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3878169 c.339G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoA 3878175 c.333G>T synonymous_variant 0.2 rifampicin
rpoA 3878184 c.324C>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3878193 c.315T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3878196 p.Glu104Ala missense_variant 0.18 rifampicin Uncertain significance
rpoA 3878205 c.303T>A synonymous_variant 0.17 rifampicin
rpoA 3878217 c.291A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3878259 c.249G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoA 3878271 c.237T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoA 3878274 c.234G>C synonymous_variant 0.15 rifampicin
rpoA 3878283 p.Glu75Asp missense_variant 0.16 rifampicin Uncertain significance
rpoA 3878292 c.216T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3878298 c.210A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3878301 c.207C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3878310 c.198G>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3878313 c.195G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3878322 c.186A>G synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoA 3878331 c.177A>G synonymous_variant 0.12 rifampicin Not assoc w R - Interim
rpoA 3878337 c.171T>C synonymous_variant 0.12 rifampicin Not assoc w R - Interim
rpoA 3879088 c.-581A>C upstream_gene_variant 0.13 rifampicin
rpoA 3879094 c.-587T>C upstream_gene_variant 0.14 rifampicin
rpoA 3879124 c.-617G>C upstream_gene_variant 0.12 rifampicin
rpoA 3879127 c.-620T>C upstream_gene_variant 0.12 rifampicin
rpoA 3879136 c.-629A>G upstream_gene_variant 0.12 rifampicin
rpoA 3879154 c.-647T>C upstream_gene_variant 0.12 rifampicin
rpoA 3879160 c.-653A>G upstream_gene_variant 0.12 rifampicin
clpC1 4038989 c.1716T>C synonymous_variant 0.29 pyrazinamide
clpC1 4038997 c.1708T>C synonymous_variant 0.27 pyrazinamide Not assoc w R - Interim
clpC1 4039100 c.1605C>G synonymous_variant 0.13 pyrazinamide
clpC1 4039106 c.1599G>C synonymous_variant 0.12 pyrazinamide
clpC1 4039112 c.1593C>G synonymous_variant 0.13 pyrazinamide
clpC1 4039118 c.1587C>G synonymous_variant 0.14 pyrazinamide
clpC1 4039121 c.1584T>C synonymous_variant 0.13 pyrazinamide
clpC1 4039166 c.1539G>A synonymous_variant 0.21 pyrazinamide
clpC1 4039169 c.1536A>G synonymous_variant 0.21 pyrazinamide
clpC1 4039172 c.1533A>G synonymous_variant 0.2 pyrazinamide
clpC1 4039178 c.1527G>C synonymous_variant 0.23 pyrazinamide
clpC1 4039183 c.1522T>C synonymous_variant 0.23 pyrazinamide
clpC1 4039190 c.1515C>T synonymous_variant 0.24 pyrazinamide
clpC1 4039220 c.1485G>C synonymous_variant 0.27 pyrazinamide
clpC1 4039265 c.1440C>T synonymous_variant 0.25 pyrazinamide
clpC1 4039274 c.1431G>C synonymous_variant 0.22 pyrazinamide Not assoc w R - Interim
clpC1 4039277 c.1428C>G synonymous_variant 0.22 pyrazinamide
clpC1 4039280 c.1425G>T synonymous_variant 0.22 pyrazinamide Not assoc w R - Interim
clpC1 4039283 c.1422C>T synonymous_variant 0.2 pyrazinamide
clpC1 4039286 c.1419T>G synonymous_variant 0.22 pyrazinamide
clpC1 4039292 c.1413C>T synonymous_variant 0.25 pyrazinamide
clpC1 4039316 p.Glu463Asp missense_variant 0.18 pyrazinamide
clpC1 4039319 c.1386T>A synonymous_variant 0.14 pyrazinamide
clpC1 4039322 c.1383T>G synonymous_variant 0.14 pyrazinamide
clpC1 4039328 c.1377A>C synonymous_variant 0.13 pyrazinamide
clpC1 4039360 p.Ser449Arg missense_variant 0.13 pyrazinamide
clpC1 4039361 c.1344C>G synonymous_variant 0.12 pyrazinamide
clpC1 4039430 c.1275T>C synonymous_variant 0.19 pyrazinamide
clpC1 4039442 c.1263A>G synonymous_variant 0.18 pyrazinamide
clpC1 4039451 c.1254G>A synonymous_variant 0.12 pyrazinamide
clpC1 4039586 c.1119G>C synonymous_variant 0.22 pyrazinamide
clpC1 4039589 c.1116G>C synonymous_variant 0.21 pyrazinamide
clpC1 4039610 c.1095G>C synonymous_variant 0.28 pyrazinamide
clpC1 4039616 c.1089G>C synonymous_variant 0.27 pyrazinamide
clpC1 4039622 c.1083C>T synonymous_variant 0.31 pyrazinamide
clpC1 4039649 c.1056G>T synonymous_variant 0.35 pyrazinamide
clpC1 4039652 c.1053G>C synonymous_variant 0.39 pyrazinamide
clpC1 4039685 c.1020C>T synonymous_variant 0.46 pyrazinamide
clpC1 4039694 c.1011G>C synonymous_variant 0.47 pyrazinamide
clpC1 4039724 c.981A>G synonymous_variant 0.45 pyrazinamide
clpC1 4039733 c.972G>C synonymous_variant 0.46 pyrazinamide
clpC1 4039739 c.966C>G synonymous_variant 0.4 pyrazinamide
clpC1 4039751 c.954A>G synonymous_variant 0.41 pyrazinamide
clpC1 4039757 c.948A>G synonymous_variant 0.34 pyrazinamide
clpC1 4039760 c.945T>C synonymous_variant 0.31 pyrazinamide
clpC1 4039766 c.939T>C synonymous_variant 0.28 pyrazinamide
clpC1 4039769 c.936C>G synonymous_variant 0.28 pyrazinamide
clpC1 4039775 c.930G>C synonymous_variant 0.28 pyrazinamide
clpC1 4039778 c.927A>G synonymous_variant 0.27 pyrazinamide
clpC1 4039787 c.918G>C synonymous_variant 0.26 pyrazinamide
clpC1 4039793 c.912C>G synonymous_variant 0.27 pyrazinamide
clpC1 4039844 c.861C>T synonymous_variant 0.23 pyrazinamide Not assoc w R - Interim
clpC1 4039850 c.855T>C synonymous_variant 0.25 pyrazinamide
clpC1 4039865 c.840T>C synonymous_variant 0.27 pyrazinamide
clpC1 4039904 c.801A>G synonymous_variant 0.25 pyrazinamide
clpC1 4039907 c.798G>A synonymous_variant 0.24 pyrazinamide Not assoc w R - Interim
clpC1 4039931 c.774T>C synonymous_variant 0.18 pyrazinamide
clpC1 4039934 c.771G>C synonymous_variant 0.16 pyrazinamide
clpC1 4039943 c.762G>C synonymous_variant 0.16 pyrazinamide
clpC1 4039952 c.753T>C synonymous_variant 0.2 pyrazinamide
clpC1 4039958 c.747G>C synonymous_variant 0.21 pyrazinamide
clpC1 4039964 c.741C>G synonymous_variant 0.2 pyrazinamide
clpC1 4039975 p.Asp244Asn missense_variant 0.21 pyrazinamide Uncertain significance
clpC1 4039979 c.726C>G synonymous_variant 0.2 pyrazinamide
clpC1 4039982 c.723G>A synonymous_variant 0.21 pyrazinamide Not assoc w R - Interim
clpC1 4040000 c.705C>T synonymous_variant 0.21 pyrazinamide
clpC1 4040021 c.684A>C synonymous_variant 0.21 pyrazinamide Not assoc w R - Interim
clpC1 4040024 c.681A>G synonymous_variant 0.19 pyrazinamide
clpC1 4040033 c.672G>C synonymous_variant 0.22 pyrazinamide
clpC1 4040042 c.663C>T synonymous_variant 0.25 pyrazinamide Not assoc w R - Interim
clpC1 4040057 c.648C>T synonymous_variant 0.23 pyrazinamide
panD 4044872 c.-591C>T upstream_gene_variant 1.0 pyrazinamide
glpK 4138529 c.1227G>C synonymous_variant 0.11 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138535 p.Asp407Glu missense_variant 0.12 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin
rifampicin Uncertain significance
isoniazid Uncertain significance
glpK 4138568 c.1188A>C synonymous_variant 0.13 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138622 c.1134C>T synonymous_variant 0.92 ethambutol Not assoc w R
moxifloxacin Not assoc w R
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R
rifampicin Not assoc w R
isoniazid Not assoc w R
embC 4242075 p.Arg738Gln missense_variant 1.0 ethambutol Not assoc w R
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
ethA 4326090 c.1384C>T synonymous_variant 1.0 ethionamide Not assoc w R - Interim
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 capreomycin
amikacin
kanamycin
gid 4407588 c.615A>G synonymous_variant 1.0 streptomycin Not assoc w R