TB-Profiler

Lineage	Family	RDs	Frequency
lineage4	Euro-American	None	1.0
lineage4.9	Euro-American (H37Rv-like)	None	1.0

Gene	Chromosome position	Mutation	Type	Estimated fraction	Drugs	Confidence	Comment
rrs	1472307	n.462C>T	non_coding_transcript_exon_variant	1.0	streptomycin	Uncertain significance	Mutation from literature
rrs	1472644	n.799C>T	non_coding_transcript_exon_variant	0.82	streptomycin	Uncertain significance	Mutation from literature

Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance

Gene	Chromosome position	Mutation	Type	Estimated fraction	Drugs	Confidence
rpoC	764398	c.1029G>C	synonymous_variant	0.91	rifampicin
rpoC	764404	c.1035C>T	synonymous_variant	0.91	rifampicin	Not assoc w R - Interim
rpoC	764405	c.1036_1038delAGGinsCT	frameshift_variant&missense_variant	1.0	rifampicin
rpoC	764428	c.1059G>T	synonymous_variant	1.0	rifampicin
rpoC	764434	c.1065A>G	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoC	764435	c.1066_1068delAGGinsCC	frameshift_variant&missense_variant	1.0	rifampicin
rpoC	764438	p.Leu357Met	missense_variant	1.0	rifampicin
rpoC	764441	c.1072_1074delATCinsCG	frameshift_variant&missense_variant	1.0	rifampicin
rpoC	764449	c.1080G>C	synonymous_variant	1.0	rifampicin
rpoC	764455	c.1086G>T	synonymous_variant	1.0	rifampicin
rpoC	764461	c.1092A>G	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoC	764470	c.1101C>G	synonymous_variant	1.0	rifampicin
rrs	1471923	n.78T>C	non_coding_transcript_exon_variant	1.0	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1471934	n.89A>G	non_coding_transcript_exon_variant	1.0	streptomycin	Uncertain significance
					kanamycin
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1471985	n.140T>C	non_coding_transcript_exon_variant	1.0	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1471986	n.141C>T	non_coding_transcript_exon_variant	1.0	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472027	n.184_188delCGGGA	non_coding_transcript_exon_variant	1.0	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472037	n.192A>T	non_coding_transcript_exon_variant	1.0	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472038	n.193_194insTA	non_coding_transcript_exon_variant	1.0	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472041	n.196C>G	non_coding_transcript_exon_variant	1.0	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472042	n.197_198insG	non_coding_transcript_exon_variant	1.0	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472053	n.211_212delGC	non_coding_transcript_exon_variant	1.0	streptomycin
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472057	n.212C>T	non_coding_transcript_exon_variant	1.0	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472061	n.216A>T	non_coding_transcript_exon_variant	1.0	streptomycin
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472062	n.217G>T	non_coding_transcript_exon_variant	1.0	streptomycin	Uncertain significance
					kanamycin
					capreomycin
					amikacin
rrs	1472069	n.224G>A	non_coding_transcript_exon_variant	1.0	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472078	n.233C>T	non_coding_transcript_exon_variant	0.58	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472106	n.261G>A	non_coding_transcript_exon_variant	0.98	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1472108	n.263C>T	non_coding_transcript_exon_variant	0.99	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472123	n.278A>G	non_coding_transcript_exon_variant	0.99	streptomycin
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472138	n.293C>A	non_coding_transcript_exon_variant	0.98	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472147	n.302G>T	non_coding_transcript_exon_variant	0.97	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472150	n.305T>G	non_coding_transcript_exon_variant	1.0	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472151	n.306C>T	non_coding_transcript_exon_variant	0.99	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1472160	n.315C>T	non_coding_transcript_exon_variant	0.96	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472278	n.433C>T	non_coding_transcript_exon_variant	0.99	streptomycin
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472279	n.434T>C	non_coding_transcript_exon_variant	0.99	streptomycin
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472285	n.440A>G	non_coding_transcript_exon_variant	0.99	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472289	n.444T>G	non_coding_transcript_exon_variant	0.99	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472290	n.445C>G	non_coding_transcript_exon_variant	0.99	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472296	n.454_458delTCCGG	non_coding_transcript_exon_variant	1.0	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472303	n.458G>C	non_coding_transcript_exon_variant	1.0	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472309	n.464_470delCTCGGATinsG	non_coding_transcript_exon_variant	1.0	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472324	n.479G>C	non_coding_transcript_exon_variant	0.99	streptomycin	Uncertain significance
					kanamycin
					capreomycin
					amikacin
rrs	1472325	n.480G>C	non_coding_transcript_exon_variant	0.99	streptomycin	Uncertain significance
					kanamycin
					capreomycin
					amikacin
rrs	1472344	n.499C>T	non_coding_transcript_exon_variant	1.0	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Not assoc w R
					amikacin	Not assoc w R
rrs	1472382	n.537G>A	non_coding_transcript_exon_variant	0.99	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1472431	n.586G>A	non_coding_transcript_exon_variant	0.99	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472435	n.590T>C	non_coding_transcript_exon_variant	0.99	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472438	n.593T>C	non_coding_transcript_exon_variant	0.99	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472439	n.594C>T	non_coding_transcript_exon_variant	0.99	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472447	n.602C>T	non_coding_transcript_exon_variant	0.99	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472448	n.603T>C	non_coding_transcript_exon_variant	0.99	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472452	n.607G>A	non_coding_transcript_exon_variant	1.0	streptomycin
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472464	n.619A>G	non_coding_transcript_exon_variant	1.0	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472471	n.626G>A	non_coding_transcript_exon_variant	0.99	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472484	n.639A>T	non_coding_transcript_exon_variant	0.99	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472489	n.644A>T	non_coding_transcript_exon_variant	0.99	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472498	n.653C>T	non_coding_transcript_exon_variant	0.99	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472504	n.659A>T	non_coding_transcript_exon_variant	0.98	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472505	n.660G>A	non_coding_transcript_exon_variant	0.98	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472530	n.685G>A	non_coding_transcript_exon_variant	0.99	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1472558	n.713G>A	non_coding_transcript_exon_variant	0.92	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472569	n.724G>A	non_coding_transcript_exon_variant	0.92	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472573	n.728C>T	non_coding_transcript_exon_variant	0.92	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472574	n.729T>A	non_coding_transcript_exon_variant	0.92	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472584	n.739A>T	non_coding_transcript_exon_variant	0.92	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472607	n.762G>A	non_coding_transcript_exon_variant	0.9	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472612	n.767G>T	non_coding_transcript_exon_variant	0.89	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472616	n.771G>A	non_coding_transcript_exon_variant	0.95	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472660	n.815T>C	non_coding_transcript_exon_variant	0.81	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472661	n.816A>G	non_coding_transcript_exon_variant	0.97	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1472670	n.825_836delGGGTTTCCTTCCinsAGGGACCTT	non_coding_transcript_exon_variant	1.0	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472687	n.842delAinsGTT	non_coding_transcript_exon_variant	1.0	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472690	n.845C>T	non_coding_transcript_exon_variant	0.99	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin
rrs	1472713	n.868T>C	non_coding_transcript_exon_variant	0.99	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1472714	n.869A>G	non_coding_transcript_exon_variant	0.83	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472828	n.983T>C	non_coding_transcript_exon_variant	1.0	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Not assoc w R
					amikacin	Not assoc w R
rrs	1472836	n.991G>A	non_coding_transcript_exon_variant	1.0	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472840	n.995A>T	non_coding_transcript_exon_variant	1.0	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472843	n.998_999insT	non_coding_transcript_exon_variant	1.0	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472846	n.1002delG	non_coding_transcript_exon_variant	1.0	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472849	n.1004C>G	non_coding_transcript_exon_variant	1.0	streptomycin
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472850	n.1005T>C	non_coding_transcript_exon_variant	1.0	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472855	n.1011_1012insGT	non_coding_transcript_exon_variant	1.0	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472859	n.1014_1016delGCGinsT	non_coding_transcript_exon_variant	1.0	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472874	n.1029C>T	non_coding_transcript_exon_variant	1.0	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472875	n.1030T>A	non_coding_transcript_exon_variant	1.0	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472880	n.1035G>A	non_coding_transcript_exon_variant	1.0	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472957	n.1112C>T	non_coding_transcript_exon_variant	1.0	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472973	n.1128A>T	non_coding_transcript_exon_variant	1.0	streptomycin
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472987	n.1142G>A	non_coding_transcript_exon_variant	0.99	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473005	n.1160C>T	non_coding_transcript_exon_variant	0.98	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1473026	n.1181T>C	non_coding_transcript_exon_variant	0.98	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473089	n.1244A>T	non_coding_transcript_exon_variant	0.92	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473091	n.1246G>C	non_coding_transcript_exon_variant	0.91	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1473094	n.1249T>A	non_coding_transcript_exon_variant	0.91	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473099	n.1254T>G	non_coding_transcript_exon_variant	0.91	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473100	n.1255G>C	non_coding_transcript_exon_variant	0.99	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1473102	n.1257C>T	non_coding_transcript_exon_variant	0.96	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473104	n.1259C>T	non_coding_transcript_exon_variant	1.0	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473109	n.1264T>G	non_coding_transcript_exon_variant	0.91	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1473111	n.1266A>G	non_coding_transcript_exon_variant	1.0	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473115	n.1270G>T	non_coding_transcript_exon_variant	0.96	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473120	n.1275C>G	non_coding_transcript_exon_variant	0.9	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1473121	n.1276T>C	non_coding_transcript_exon_variant	0.95	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Not assoc w R
					amikacin	Not assoc w R
rrs	1473123	n.1278A>T	non_coding_transcript_exon_variant	1.0	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473129	n.1284C>T	non_coding_transcript_exon_variant	0.95	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473135	n.1290C>T	non_coding_transcript_exon_variant	0.92	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin
rrs	1473145	n.1300C>T	non_coding_transcript_exon_variant	0.95	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473166	n.1321G>A	non_coding_transcript_exon_variant	0.95	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473202	n.1357C>T	non_coding_transcript_exon_variant	0.93	streptomycin
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473259	n.1414C>T	non_coding_transcript_exon_variant	0.99	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1473276	n.1431A>G	non_coding_transcript_exon_variant	1.0	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473282	n.1437_1438delCTinsTCA	non_coding_transcript_exon_variant	0.98	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1473287	n.1442_1448delCCTCGGGinsTCGTTT	non_coding_transcript_exon_variant	1.0	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1473301	n.1456T>C	non_coding_transcript_exon_variant	1.0	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrl	1474140	n.483C>T	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1474140	n.483C>T	non_coding_transcript_exon_variant	1.0	linezolid	Uncertain significance
rrl	1474143	n.486T>C	non_coding_transcript_exon_variant	1.0	capreomycin
rrl	1474143	n.486T>C	non_coding_transcript_exon_variant	1.0	linezolid
rrl	1474151	n.494C>T	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1474151	n.494C>T	non_coding_transcript_exon_variant	1.0	linezolid	Uncertain significance
rrl	1474181	n.524_529delCCTCGAinsTAGTG	non_coding_transcript_exon_variant	1.0	capreomycin
rrl	1474181	n.524_529delCCTCGAinsTAGTG	non_coding_transcript_exon_variant	1.0	linezolid
rrl	1474200	n.545delT	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1474200	n.545delT	non_coding_transcript_exon_variant	1.0	linezolid	Uncertain significance
rrl	1474249	n.592G>T	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1474249	n.592G>T	non_coding_transcript_exon_variant	1.0	linezolid	Uncertain significance
rrl	1474253	n.596A>T	non_coding_transcript_exon_variant	0.97	capreomycin	Uncertain significance
rrl	1474253	n.596A>T	non_coding_transcript_exon_variant	0.97	linezolid	Uncertain significance
rrl	1474263	n.606G>A	non_coding_transcript_exon_variant	0.97	capreomycin	Uncertain significance
rrl	1474263	n.606G>A	non_coding_transcript_exon_variant	0.97	linezolid
rrl	1474269	n.612C>T	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1474269	n.612C>T	non_coding_transcript_exon_variant	1.0	linezolid	Uncertain significance
rrl	1474286	n.629_630delCTinsA	non_coding_transcript_exon_variant	1.0	capreomycin
rrl	1474286	n.629_630delCTinsA	non_coding_transcript_exon_variant	1.0	linezolid
rrl	1474293	n.637_650delCCTCTCCGGAGGAG	non_coding_transcript_exon_variant	1.0	capreomycin
rrl	1474293	n.637_650delCCTCTCCGGAGGAG	non_coding_transcript_exon_variant	1.0	linezolid
rrl	1474309	n.652G>T	non_coding_transcript_exon_variant	0.98	capreomycin
rrl	1474309	n.652G>T	non_coding_transcript_exon_variant	0.98	linezolid
rrl	1474311	n.654_655insT	non_coding_transcript_exon_variant	0.98	capreomycin
rrl	1474311	n.654_655insT	non_coding_transcript_exon_variant	0.98	linezolid
rrl	1474351	n.694G>C	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1474351	n.694G>C	non_coding_transcript_exon_variant	1.0	linezolid
rrl	1474353	n.696A>G	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1474353	n.696A>G	non_coding_transcript_exon_variant	1.0	linezolid	Uncertain significance
rrl	1474362	n.705A>G	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1474362	n.705A>G	non_coding_transcript_exon_variant	1.0	linezolid	Uncertain significance
rrl	1474384	n.727C>T	non_coding_transcript_exon_variant	0.92	capreomycin
rrl	1474384	n.727C>T	non_coding_transcript_exon_variant	0.92	linezolid
rrl	1474387	n.730C>T	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1474387	n.730C>T	non_coding_transcript_exon_variant	1.0	linezolid	Uncertain significance
rrl	1474447	n.790G>A	non_coding_transcript_exon_variant	0.88	capreomycin
rrl	1474447	n.790G>A	non_coding_transcript_exon_variant	0.88	linezolid
rrl	1474451	n.794T>C	non_coding_transcript_exon_variant	0.95	capreomycin
rrl	1474451	n.794T>C	non_coding_transcript_exon_variant	0.95	linezolid
rrl	1474467	n.810A>G	non_coding_transcript_exon_variant	1.0	capreomycin
rrl	1474467	n.810A>G	non_coding_transcript_exon_variant	1.0	linezolid
rrl	1474487	n.830G>T	non_coding_transcript_exon_variant	0.97	capreomycin
rrl	1474487	n.830G>T	non_coding_transcript_exon_variant	0.97	linezolid
rrl	1474495	n.838G>A	non_coding_transcript_exon_variant	1.0	capreomycin
rrl	1474495	n.838G>A	non_coding_transcript_exon_variant	1.0	linezolid
rrl	1474496	n.839C>G	non_coding_transcript_exon_variant	0.95	capreomycin	Uncertain significance
rrl	1474496	n.839C>G	non_coding_transcript_exon_variant	0.95	linezolid
rrl	1474497	n.840G>C	non_coding_transcript_exon_variant	0.93	capreomycin	Uncertain significance
rrl	1474497	n.840G>C	non_coding_transcript_exon_variant	0.93	linezolid	Uncertain significance
rrl	1474498	n.841G>T	non_coding_transcript_exon_variant	1.0	capreomycin
rrl	1474498	n.841G>T	non_coding_transcript_exon_variant	1.0	linezolid
rrl	1474505	n.848C>G	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1474505	n.848C>G	non_coding_transcript_exon_variant	1.0	linezolid	Uncertain significance
rrl	1474506	n.849C>G	non_coding_transcript_exon_variant	0.93	capreomycin	Uncertain significance
rrl	1474506	n.849C>G	non_coding_transcript_exon_variant	0.93	linezolid	Uncertain significance
rrl	1474507	n.850G>T	non_coding_transcript_exon_variant	0.93	capreomycin	Uncertain significance
rrl	1474507	n.850G>T	non_coding_transcript_exon_variant	0.93	linezolid	Uncertain significance
rrl	1474508	n.851C>T	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1474508	n.851C>T	non_coding_transcript_exon_variant	1.0	linezolid	Uncertain significance
rrl	1474517	n.860C>G	non_coding_transcript_exon_variant	0.95	capreomycin
rrl	1474517	n.860C>G	non_coding_transcript_exon_variant	0.95	linezolid
rrl	1474527	n.870T>G	non_coding_transcript_exon_variant	0.98	capreomycin	Uncertain significance
rrl	1474527	n.870T>G	non_coding_transcript_exon_variant	0.98	linezolid	Uncertain significance
rrl	1474537	n.880G>A	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1474537	n.880G>A	non_coding_transcript_exon_variant	1.0	linezolid	Uncertain significance
rrl	1474542	n.885A>C	non_coding_transcript_exon_variant	0.98	capreomycin	Uncertain significance
rrl	1474542	n.885A>C	non_coding_transcript_exon_variant	0.98	linezolid	Uncertain significance
rrl	1474734	n.1077G>T	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1474734	n.1077G>T	non_coding_transcript_exon_variant	1.0	linezolid	Uncertain significance
rrl	1474736	n.1079C>T	non_coding_transcript_exon_variant	0.98	capreomycin
rrl	1474736	n.1079C>T	non_coding_transcript_exon_variant	0.98	linezolid
rrl	1474749	n.1092C>T	non_coding_transcript_exon_variant	0.97	capreomycin	Uncertain significance
rrl	1474749	n.1092C>T	non_coding_transcript_exon_variant	0.97	linezolid	Uncertain significance
rrl	1474751	n.1094G>A	non_coding_transcript_exon_variant	0.97	capreomycin
rrl	1474751	n.1094G>A	non_coding_transcript_exon_variant	0.97	linezolid
rrl	1474753	n.1097delC	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1474753	n.1097delC	non_coding_transcript_exon_variant	1.0	linezolid	Uncertain significance
rrl	1474760	n.1103A>G	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1474760	n.1103A>G	non_coding_transcript_exon_variant	1.0	linezolid	Uncertain significance
rrl	1474794	n.1137C>T	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1474794	n.1137C>T	non_coding_transcript_exon_variant	1.0	linezolid	Uncertain significance
rrl	1474798	n.1141C>G	non_coding_transcript_exon_variant	0.96	capreomycin
rrl	1474798	n.1141C>G	non_coding_transcript_exon_variant	0.96	linezolid
rrl	1474803	n.1146G>A	non_coding_transcript_exon_variant	0.96	capreomycin	Uncertain significance
rrl	1474803	n.1146G>A	non_coding_transcript_exon_variant	0.96	linezolid	Uncertain significance
rrl	1474812	n.1155G>A	non_coding_transcript_exon_variant	0.96	capreomycin	Uncertain significance
rrl	1474812	n.1155G>A	non_coding_transcript_exon_variant	0.96	linezolid	Uncertain significance
rrl	1474823	n.1166C>G	non_coding_transcript_exon_variant	0.97	capreomycin	Uncertain significance
rrl	1474823	n.1166C>G	non_coding_transcript_exon_variant	0.97	linezolid	Uncertain significance
rrl	1474824	n.1167A>G	non_coding_transcript_exon_variant	0.99	capreomycin	Uncertain significance
rrl	1474824	n.1167A>G	non_coding_transcript_exon_variant	0.99	linezolid	Uncertain significance
rrl	1474825	n.1168G>A	non_coding_transcript_exon_variant	0.96	capreomycin
rrl	1474825	n.1168G>A	non_coding_transcript_exon_variant	0.96	linezolid
rrl	1474830	n.1173A>G	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1474830	n.1173A>G	non_coding_transcript_exon_variant	1.0	linezolid	Uncertain significance
rrl	1474832	n.1175A>T	non_coding_transcript_exon_variant	0.97	capreomycin	Uncertain significance
rrl	1474832	n.1175A>T	non_coding_transcript_exon_variant	0.97	linezolid	Uncertain significance
rrl	1474837	n.1180A>G	non_coding_transcript_exon_variant	0.95	capreomycin
rrl	1474837	n.1180A>G	non_coding_transcript_exon_variant	0.95	linezolid
rrl	1474864	n.1207C>T	non_coding_transcript_exon_variant	1.0	capreomycin	Not assoc w R
rrl	1474864	n.1207C>T	non_coding_transcript_exon_variant	1.0	linezolid	Uncertain significance
rrl	1474896	n.1239A>G	non_coding_transcript_exon_variant	0.96	capreomycin	Uncertain significance
rrl	1474896	n.1239A>G	non_coding_transcript_exon_variant	0.96	linezolid	Uncertain significance
rrl	1474901	n.1244A>G	non_coding_transcript_exon_variant	0.96	capreomycin
rrl	1474901	n.1244A>G	non_coding_transcript_exon_variant	0.96	linezolid
rrl	1474904	n.1247G>C	non_coding_transcript_exon_variant	0.97	capreomycin	Uncertain significance
rrl	1474904	n.1247G>C	non_coding_transcript_exon_variant	0.97	linezolid	Uncertain significance
rrl	1474913	n.1256T>C	non_coding_transcript_exon_variant	0.99	capreomycin	Uncertain significance
rrl	1474913	n.1256T>C	non_coding_transcript_exon_variant	0.99	linezolid	Uncertain significance
rrl	1474921	n.1264C>T	non_coding_transcript_exon_variant	0.95	capreomycin	Uncertain significance
rrl	1474921	n.1264C>T	non_coding_transcript_exon_variant	0.95	linezolid	Uncertain significance
rrl	1474932	n.1275C>T	non_coding_transcript_exon_variant	0.96	capreomycin	Uncertain significance
rrl	1474932	n.1275C>T	non_coding_transcript_exon_variant	0.96	linezolid	Uncertain significance
rrl	1475713	n.2056C>T	non_coding_transcript_exon_variant	0.96	capreomycin
rrl	1475713	n.2056C>T	non_coding_transcript_exon_variant	0.96	linezolid
rrl	1475753	n.2096C>T	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1475753	n.2096C>T	non_coding_transcript_exon_variant	1.0	linezolid
rrl	1475758	n.2101A>G	non_coding_transcript_exon_variant	0.99	capreomycin
rrl	1475758	n.2101A>G	non_coding_transcript_exon_variant	0.99	linezolid
rrl	1475759	n.2102C>A	non_coding_transcript_exon_variant	0.98	capreomycin
rrl	1475759	n.2102C>A	non_coding_transcript_exon_variant	0.98	linezolid
rrl	1475760	n.2103C>T	non_coding_transcript_exon_variant	0.61	capreomycin
rrl	1475760	n.2103C>T	non_coding_transcript_exon_variant	0.61	linezolid
rrl	1475762	n.2105G>T	non_coding_transcript_exon_variant	0.99	capreomycin	Uncertain significance
rrl	1475762	n.2105G>T	non_coding_transcript_exon_variant	0.99	linezolid
rrl	1475763	n.2106C>T	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1475763	n.2106C>T	non_coding_transcript_exon_variant	1.0	linezolid
rrl	1475764	n.2107A>T	non_coding_transcript_exon_variant	1.0	capreomycin
rrl	1475764	n.2107A>T	non_coding_transcript_exon_variant	1.0	linezolid
rrl	1475765	n.2108A>T	non_coding_transcript_exon_variant	1.0	capreomycin
rrl	1475765	n.2108A>T	non_coding_transcript_exon_variant	1.0	linezolid
rrl	1475769	n.2112_2113insC	non_coding_transcript_exon_variant	0.99	capreomycin
rrl	1475769	n.2112_2113insC	non_coding_transcript_exon_variant	0.99	linezolid
rrl	1475877	n.2220C>G	non_coding_transcript_exon_variant	0.95	capreomycin
rrl	1475877	n.2220C>G	non_coding_transcript_exon_variant	0.95	linezolid
rrl	1475878	n.2221T>A	non_coding_transcript_exon_variant	0.95	capreomycin
rrl	1475878	n.2221T>A	non_coding_transcript_exon_variant	0.95	linezolid
rrl	1475879	n.2222T>C	non_coding_transcript_exon_variant	0.95	capreomycin
rrl	1475879	n.2222T>C	non_coding_transcript_exon_variant	0.95	linezolid
rrl	1475881	n.2224T>C	non_coding_transcript_exon_variant	0.96	capreomycin
rrl	1475881	n.2224T>C	non_coding_transcript_exon_variant	0.96	linezolid
rrl	1475883	n.2226A>T	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1475883	n.2226A>T	non_coding_transcript_exon_variant	1.0	linezolid	Uncertain significance
rrl	1475884	n.2227A>G	non_coding_transcript_exon_variant	0.96	capreomycin	Uncertain significance
rrl	1475884	n.2227A>G	non_coding_transcript_exon_variant	0.96	linezolid	Uncertain significance
rrl	1475897	n.2240T>C	non_coding_transcript_exon_variant	0.96	capreomycin	Uncertain significance
rrl	1475897	n.2240T>C	non_coding_transcript_exon_variant	0.96	linezolid	Uncertain significance
rrl	1475900	n.2243A>G	non_coding_transcript_exon_variant	0.96	capreomycin	Uncertain significance
rrl	1475900	n.2243A>G	non_coding_transcript_exon_variant	0.96	linezolid
rrl	1475902	n.2245T>C	non_coding_transcript_exon_variant	0.96	capreomycin	Uncertain significance
rrl	1475902	n.2245T>C	non_coding_transcript_exon_variant	0.96	linezolid
rrl	1475906	n.2249C>T	non_coding_transcript_exon_variant	0.96	capreomycin	Uncertain significance
rrl	1475906	n.2249C>T	non_coding_transcript_exon_variant	0.96	linezolid	Uncertain significance
rrl	1475916	n.2259C>G	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1475916	n.2259C>G	non_coding_transcript_exon_variant	1.0	linezolid	Uncertain significance
rrl	1475975	n.2318C>T	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1475975	n.2318C>T	non_coding_transcript_exon_variant	1.0	linezolid	Uncertain significance
rrl	1475977	n.2320A>G	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1475977	n.2320A>G	non_coding_transcript_exon_variant	1.0	linezolid	Uncertain significance
rrl	1475988	n.2331A>G	non_coding_transcript_exon_variant	1.0	capreomycin	Not assoc w R
rrl	1475988	n.2331A>G	non_coding_transcript_exon_variant	1.0	linezolid	Uncertain significance
rrl	1475997	n.2340A>T	non_coding_transcript_exon_variant	0.94	capreomycin	Uncertain significance
rrl	1475997	n.2340A>T	non_coding_transcript_exon_variant	0.94	linezolid	Uncertain significance
rrl	1475998	n.2341C>T	non_coding_transcript_exon_variant	0.97	capreomycin
rrl	1475998	n.2341C>T	non_coding_transcript_exon_variant	0.97	linezolid	Uncertain significance
rrl	1476001	n.2344T>C	non_coding_transcript_exon_variant	0.97	capreomycin	Uncertain significance
rrl	1476001	n.2344T>C	non_coding_transcript_exon_variant	0.97	linezolid	Uncertain significance
rrl	1476131	n.2474C>T	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1476131	n.2474C>T	non_coding_transcript_exon_variant	1.0	linezolid	Uncertain significance
rrl	1476164	n.2507A>G	non_coding_transcript_exon_variant	0.96	capreomycin	Uncertain significance
rrl	1476164	n.2507A>G	non_coding_transcript_exon_variant	0.96	linezolid	Uncertain significance
rrl	1476165	n.2508T>A	non_coding_transcript_exon_variant	0.99	capreomycin	Uncertain significance
rrl	1476165	n.2508T>A	non_coding_transcript_exon_variant	0.99	linezolid	Uncertain significance
rrl	1476188	n.2531C>T	non_coding_transcript_exon_variant	0.96	capreomycin
rrl	1476188	n.2531C>T	non_coding_transcript_exon_variant	0.96	linezolid
rrl	1476194	n.2537A>G	non_coding_transcript_exon_variant	1.0	capreomycin	Not assoc w R
rrl	1476194	n.2537A>G	non_coding_transcript_exon_variant	1.0	linezolid	Uncertain significance
rrl	1476200	n.2543A>T	non_coding_transcript_exon_variant	1.0	capreomycin	Not assoc w R
rrl	1476200	n.2543A>T	non_coding_transcript_exon_variant	1.0	linezolid	Uncertain significance
rrl	1476201	n.2544C>T	non_coding_transcript_exon_variant	1.0	capreomycin	Not assoc w R
rrl	1476201	n.2544C>T	non_coding_transcript_exon_variant	1.0	linezolid	Uncertain significance
rrl	1476213	n.2556G>T	non_coding_transcript_exon_variant	0.95	capreomycin
rrl	1476213	n.2556G>T	non_coding_transcript_exon_variant	0.95	linezolid
rrl	1476214	n.2557G>T	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1476214	n.2557G>T	non_coding_transcript_exon_variant	1.0	linezolid	Uncertain significance
rrl	1476215	n.2558C>T	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1476215	n.2558C>T	non_coding_transcript_exon_variant	1.0	linezolid	Uncertain significance
rrl	1476224	n.2567A>G	non_coding_transcript_exon_variant	0.9	capreomycin	Uncertain significance
rrl	1476224	n.2567A>G	non_coding_transcript_exon_variant	0.9	linezolid	Uncertain significance
rrl	1476234	n.2577G>A	non_coding_transcript_exon_variant	0.82	capreomycin
rrl	1476234	n.2577G>A	non_coding_transcript_exon_variant	0.82	linezolid
rrl	1476245	n.2588C>T	non_coding_transcript_exon_variant	0.81	capreomycin	Uncertain significance
rrl	1476245	n.2588C>T	non_coding_transcript_exon_variant	0.81	linezolid	Uncertain significance
rrl	1476250	n.2593C>G	non_coding_transcript_exon_variant	0.99	capreomycin	Uncertain significance
rrl	1476250	n.2593C>G	non_coding_transcript_exon_variant	0.99	linezolid	Uncertain significance
rrl	1476255	n.2598A>T	non_coding_transcript_exon_variant	0.79	capreomycin
rrl	1476255	n.2598A>T	non_coding_transcript_exon_variant	0.79	linezolid
rrl	1476256	n.2599A>G	non_coding_transcript_exon_variant	0.79	capreomycin	Uncertain significance
rrl	1476256	n.2599A>G	non_coding_transcript_exon_variant	0.79	linezolid	Uncertain significance
rrl	1476257	n.2600G>C	non_coding_transcript_exon_variant	0.99	capreomycin	Uncertain significance
rrl	1476257	n.2600G>C	non_coding_transcript_exon_variant	0.99	linezolid	Uncertain significance
rrl	1476260	n.2603A>G	non_coding_transcript_exon_variant	1.0	capreomycin	Not assoc w R
rrl	1476260	n.2603A>G	non_coding_transcript_exon_variant	1.0	linezolid	Uncertain significance
rrl	1476281	n.2624T>C	non_coding_transcript_exon_variant	0.82	capreomycin	Uncertain significance
rrl	1476281	n.2624T>C	non_coding_transcript_exon_variant	0.82	linezolid	Uncertain significance
rrl	1476297	n.2640C>T	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1476297	n.2640C>T	non_coding_transcript_exon_variant	1.0	linezolid	Uncertain significance
rrl	1476298	n.2641C>A	non_coding_transcript_exon_variant	0.8	capreomycin
rrl	1476298	n.2641C>A	non_coding_transcript_exon_variant	0.8	linezolid
rrl	1476300	n.2643G>T	non_coding_transcript_exon_variant	0.8	capreomycin
rrl	1476300	n.2643G>T	non_coding_transcript_exon_variant	0.8	linezolid
rrl	1476301	n.2644A>T	non_coding_transcript_exon_variant	0.97	capreomycin	Uncertain significance
rrl	1476301	n.2644A>T	non_coding_transcript_exon_variant	0.97	linezolid	Uncertain significance
rrl	1476307	n.2650A>T	non_coding_transcript_exon_variant	0.8	capreomycin
rrl	1476307	n.2650A>T	non_coding_transcript_exon_variant	0.8	linezolid
rrl	1476309	n.2652G>T	non_coding_transcript_exon_variant	0.8	capreomycin
rrl	1476309	n.2652G>T	non_coding_transcript_exon_variant	0.8	linezolid
rrl	1476428	n.2771C>T	non_coding_transcript_exon_variant	1.0	capreomycin	Not assoc w R
rrl	1476428	n.2771C>T	non_coding_transcript_exon_variant	1.0	linezolid	Uncertain significance
rrl	1476481	n.2824T>C	non_coding_transcript_exon_variant	0.99	capreomycin	Not assoc w R
rrl	1476481	n.2824T>C	non_coding_transcript_exon_variant	0.99	linezolid	Uncertain significance
rrl	1476523	n.2867delC	non_coding_transcript_exon_variant	1.0	capreomycin
rrl	1476523	n.2867delC	non_coding_transcript_exon_variant	1.0	linezolid
rrl	1476535	n.2878G>A	non_coding_transcript_exon_variant	0.95	capreomycin
rrl	1476535	n.2878G>A	non_coding_transcript_exon_variant	0.95	linezolid
rrl	1476536	n.2879G>A	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1476536	n.2879G>A	non_coding_transcript_exon_variant	1.0	linezolid	Uncertain significance
rrl	1476539	n.2882A>G	non_coding_transcript_exon_variant	0.98	capreomycin	Uncertain significance
rrl	1476539	n.2882A>G	non_coding_transcript_exon_variant	0.98	linezolid	Uncertain significance
rrl	1476540	n.2883C>G	non_coding_transcript_exon_variant	0.98	capreomycin	Uncertain significance
rrl	1476540	n.2883C>G	non_coding_transcript_exon_variant	0.98	linezolid	Uncertain significance
rpsA	1833961	c.420C>G	synonymous_variant	1.0	pyrazinamide
rpsA	1833970	c.429G>T	synonymous_variant	1.0	pyrazinamide
rpsA	1833976	c.435C>T	synonymous_variant	1.0	pyrazinamide
rpsA	1833979	c.438T>C	synonymous_variant	1.0	pyrazinamide
rpsA	1833988	c.447C>T	synonymous_variant	1.0	pyrazinamide
rpsA	1833991	c.450C>T	synonymous_variant	1.0	pyrazinamide
rpsA	1833994	c.453G>C	synonymous_variant	1.0	pyrazinamide
rpsA	1834000	c.459G>A	synonymous_variant	1.0	pyrazinamide
rpsA	1834003	c.462G>A	synonymous_variant	1.0	pyrazinamide
rpsA	1834012	c.471G>C	synonymous_variant	1.0	pyrazinamide
rpsA	1834015	c.474G>T	synonymous_variant	1.0	pyrazinamide
rpsA	1834018	c.477C>T	synonymous_variant	1.0	pyrazinamide
rpsA	1834025	p.Gln162Glu	missense_variant	1.0	pyrazinamide
rpsA	1834030	c.489C>T	synonymous_variant	1.0	pyrazinamide
rpsA	1834039	c.498C>T	synonymous_variant	1.0	pyrazinamide
rpsA	1834040	p.Lys167Gln	missense_variant	1.0	pyrazinamide
rpsA	1834045	c.504G>A	synonymous_variant	1.0	pyrazinamide
rpsA	1834046	c.505_507delATCinsCT	frameshift_variant&missense_variant	1.0	pyrazinamide	Uncertain significance
rpsA	1834051	p.Glu170Asp	missense_variant	1.0	pyrazinamide
rpsA	1834054	c.513C>T	synonymous_variant	1.0	pyrazinamide
rpsA	1834474	c.933C>T	synonymous_variant	1.0	pyrazinamide
rpsA	1834483	c.942G>A	synonymous_variant	1.0	pyrazinamide
rpsA	1834486	c.945G>A	synonymous_variant	1.0	pyrazinamide
rpsA	1834489	c.948T>C	synonymous_variant	1.0	pyrazinamide
rpsA	1834495	c.954G>A	synonymous_variant	1.0	pyrazinamide
rpsA	1834504	c.963G>T	synonymous_variant	1.0	pyrazinamide
rpsA	1834523	p.Glu328Gln	missense_variant	0.93	pyrazinamide
rpsA	1834528	c.987T>C	synonymous_variant	1.0	pyrazinamide
rpsA	1834540	c.999G>T	synonymous_variant	1.0	pyrazinamide	Not assoc w R - Interim
rpsA	1834543	c.1002C>A	synonymous_variant	1.0	pyrazinamide
rpsA	1834546	c.1005T>C	synonymous_variant	1.0	pyrazinamide
rpsA	1834552	c.1011G>T	synonymous_variant	0.93	pyrazinamide
rpsA	1834555	c.1014T>C	synonymous_variant	1.0	pyrazinamide
rpsA	1834556	p.Ala339Asn	missense_variant	1.0	pyrazinamide
rpsA	1834561	c.1020C>T	synonymous_variant	0.93	pyrazinamide	Not assoc w R - Interim
rpsA	1834567	p.Asp342Glu	missense_variant	0.93	pyrazinamide
rpsA	1834570	p.Asp343Glu	missense_variant	0.93	pyrazinamide
rpsA	1834573	c.1032G>C	synonymous_variant	0.93	pyrazinamide
rpsA	1834600	c.1059G>C	synonymous_variant	0.82	pyrazinamide
rpsA	1834606	c.1065C>T	synonymous_variant	1.0	pyrazinamide
rpsA	1834612	c.1071G>C	synonymous_variant	0.77	pyrazinamide
rpsA	1834618	c.1077G>C	synonymous_variant	0.7	pyrazinamide
rpsA	1834619	c.1078T>C	synonymous_variant	1.0	pyrazinamide
rpsA	1834627	c.1086C>G	synonymous_variant	0.7	pyrazinamide
rpsA	1834633	c.1092A>G	synonymous_variant	1.0	pyrazinamide
rpsA	1834636	c.1095C>A	synonymous_variant	0.7	pyrazinamide
rpsA	1834637	c.1096_1098delAATinsGC	frameshift_variant&missense_variant	0.7	pyrazinamide	Uncertain significance
rpsA	1834657	c.1116G>A	synonymous_variant	0.7	pyrazinamide	Not assoc w R - Interim

Drug	Resistance	Supporting mutations	WHO confidence	Comment
rifampicin
isoniazid
ethambutol
pyrazinamide
streptomycin	rrs	n.462C>T	Uncertain significance	Mutation from literature
streptomycin	rrs	n.799C>T	Uncertain significance	Mutation from literature
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid

TB-Profiler result