Run ID: ERR11465714
Sample name:
Date: 2024-10-04T19:53:52.278187
Number of reads: 3900024
Percentage reads mapped: 98.9
Median coverage: 90.0
Strain: lineage1.2.2.1;lineage4.4.1.1
Spoligotype:
Drug-resistance: Other
Lineage | Family | RDs | Frequency |
---|---|---|---|
lineage1.2.2.1 | Indo-Oceanic | RD239 | 0.39 |
lineage1.2.2 | Indo-Oceanic | RD239 | 0.39 |
lineage4.4.1 | Euro-American (S-type) | None | 0.6 |
lineage4 | Euro-American | None | 0.62 |
lineage4.4.1.1 | Euro-American | None | 0.59 |
lineage1 | Indo-Oceanic | RD239 | 0.35 |
lineage4.4 | Euro-American | None | 0.63 |
Drug | Resistance | Supporting mutations | WHO confidence | Comment |
---|---|---|---|---|
rifampicin | ||||
isoniazid | ||||
ethambutol | ||||
pyrazinamide | ||||
streptomycin | rrs | n.462C>T | Uncertain significance | Mutation from literature |
fluoroquinolones | ||||
moxifloxacin | ||||
ofloxacin | ||||
levofloxacin | ||||
ciprofloxacin | ||||
aminoglycosides | ||||
amikacin | ||||
capreomycin | ||||
kanamycin | ||||
cycloserine | ||||
ethionamide | ||||
clofazimine | ||||
para-aminosalicylic_acid | ||||
delamanid | ||||
bedaquiline | ||||
linezolid |
Gene | Chromosome position | Mutation | Type | Estimated fraction | Drugs | Confidence | Comment |
---|---|---|---|---|---|---|---|
rrs | 1472307 | n.462C>T | non_coding_transcript_exon_variant | 0.33 | streptomycin | Uncertain significance | Mutation from literature |
Gene | Chromosome position | Mutation | Type | Estimated fraction | Drugs | Confidence |
---|---|---|---|---|---|---|
dnaA | 237 | c.237G>A | synonymous_variant | 0.39 | isoniazid | Not assoc w R - Interim |
gyrB | 4971 | c.-269A>G | upstream_gene_variant | 0.55 | levofloxacin | |
moxifloxacin | ||||||
gyrB | 5075 | c.-165C>T | upstream_gene_variant | 0.5 | levofloxacin | |
moxifloxacin | ||||||
gyrB | 6112 | p.Met291Ile | missense_variant | 0.41 | levofloxacin | Not assoc w R |
moxifloxacin | Not assoc w R | |||||
gyrB | 6850 | c.1611C>A | synonymous_variant | 0.13 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 7362 | p.Glu21Gln | missense_variant | 1.0 | levofloxacin | Not assoc w R |
moxifloxacin | Not assoc w R | |||||
gyrA | 7585 | p.Ser95Thr | missense_variant | 1.0 | levofloxacin | Not assoc w R |
moxifloxacin | Not assoc w R | |||||
gyrA | 7595 | c.294C>G | synonymous_variant | 0.14 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7601 | c.300C>G | synonymous_variant | 0.14 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 7619 | c.318C>T | synonymous_variant | 0.23 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7631 | c.330G>C | synonymous_variant | 0.15 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7637 | c.336C>A | synonymous_variant | 0.15 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7643 | c.342C>G | synonymous_variant | 0.13 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7728 | c.427_429delAGGinsCGC | synonymous_variant | 0.21 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7796 | c.495G>T | synonymous_variant | 0.23 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7799 | c.498A>G | synonymous_variant | 0.21 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 8452 | p.Ala384Val | missense_variant | 0.39 | levofloxacin | Not assoc w R |
moxifloxacin | Not assoc w R | |||||
gyrA | 8618 | c.1317G>A | synonymous_variant | 0.15 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8619 | c.1318T>C | synonymous_variant | 0.15 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 8633 | c.1332C>T | synonymous_variant | 0.15 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8636 | c.1335A>C | synonymous_variant | 0.15 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 8642 | c.1341A>G | synonymous_variant | 0.16 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8645 | c.1344C>T | synonymous_variant | 0.16 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 8655 | p.Ile452Val | missense_variant | 0.17 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8816 | c.1515C>G | synonymous_variant | 0.12 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8829 | c.1528T>C | synonymous_variant | 0.18 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 8837 | c.1536C>A | synonymous_variant | 0.21 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8852 | c.1551T>C | synonymous_variant | 0.14 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8858 | c.1557T>G | synonymous_variant | 0.15 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 8864 | c.1563C>T | synonymous_variant | 0.14 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8867 | c.1566A>G | synonymous_variant | 0.13 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 8870 | c.1569G>C | synonymous_variant | 0.13 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 8873 | c.1572A>C | synonymous_variant | 0.13 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 8915 | c.1614A>G | synonymous_variant | 0.14 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 8924 | c.1623C>T | synonymous_variant | 0.16 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 9138 | p.Gln613Glu | missense_variant | 0.6 | levofloxacin | Not assoc w R |
moxifloxacin | Not assoc w R | |||||
gyrA | 9143 | c.1842T>C | synonymous_variant | 0.39 | levofloxacin | Not assoc w R |
moxifloxacin | Not assoc w R | |||||
gyrA | 9304 | p.Gly668Asp | missense_variant | 1.0 | levofloxacin | Not assoc w R |
moxifloxacin | Not assoc w R | |||||
Rv0010c | 13298 | p.Ile87Met | missense_variant | 0.49 | isoniazid | Not assoc w R |
Rv0010c | 13460 | c.99T>C | synonymous_variant | 0.31 | isoniazid | Not assoc w R |
fgd1 | 491060 | p.Met93Thr | missense_variant | 0.3 | pretomanid | |
delamanid | Uncertain significance | |||||
clofazimine | Uncertain significance | |||||
fgd1 | 491388 | c.606C>G | synonymous_variant | 0.15 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fgd1 | 491391 | c.609C>T | synonymous_variant | 0.16 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fgd1 | 491742 | c.960T>C | synonymous_variant | 0.4 | pretomanid | |
delamanid | Not assoc w R - Interim | |||||
clofazimine | Not assoc w R | |||||
mshA | 576511 | c.1164C>G | synonymous_variant | 0.18 | isoniazid | |
ethionamide | ||||||
mshA | 576517 | c.1170G>C | synonymous_variant | 0.18 | isoniazid | |
ethionamide | ||||||
mshA | 576634 | c.1287G>C | synonymous_variant | 0.22 | isoniazid | |
ethionamide | ||||||
ccsA | 620659 | p.Arg257Cys | missense_variant | 0.33 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
Rv0565c | 657578 | c.-108T>C | upstream_gene_variant | 0.27 | ethionamide | |
hadA | 731747 | c.-183T>C | upstream_gene_variant | 0.17 | isoniazid | |
hadA | 731753 | c.-177A>G | upstream_gene_variant | 0.16 | isoniazid | |
hadA | 731774 | c.-156T>C | upstream_gene_variant | 0.27 | isoniazid | |
hadA | 731789 | c.-141A>G | upstream_gene_variant | 0.21 | isoniazid | |
hadA | 731798 | c.-132C>G | upstream_gene_variant | 0.14 | isoniazid | |
nusG | 734116 | c.-138T>C | upstream_gene_variant | 0.32 | rifampicin | Not assoc w R |
nusG | 734439 | c.186C>G | synonymous_variant | 0.16 | rifampicin | |
nusG | 734442 | c.189G>A | synonymous_variant | 0.16 | rifampicin | |
nusG | 734451 | c.198G>C | synonymous_variant | 0.13 | rifampicin | |
nusG | 734460 | c.207G>C | synonymous_variant | 0.15 | rifampicin | |
nusG | 734475 | c.222T>C | synonymous_variant | 0.13 | rifampicin | Not assoc w R - Interim |
nusG | 734502 | c.249G>A | synonymous_variant | 0.15 | rifampicin | |
nusG | 734505 | c.252G>C | synonymous_variant | 0.15 | rifampicin | |
nusG | 734580 | c.327T>C | synonymous_variant | 0.15 | rifampicin | Not assoc w R - Interim |
nusG | 734589 | c.336G>C | synonymous_variant | 0.17 | rifampicin | |
nusG | 734895 | c.642A>G | synonymous_variant | 0.16 | rifampicin | |
mmaA3 | 737358 | c.792A>C | synonymous_variant | 0.17 | isoniazid | |
rpoB | 760091 | c.285G>C | synonymous_variant | 0.15 | rifampicin | Not assoc w R - Interim |
rpoB | 760101 | c.295T>C | synonymous_variant | 0.19 | rifampicin | Not assoc w R - Interim |
rpoB | 760112 | c.306T>C | synonymous_variant | 0.25 | rifampicin | |
rpoB | 760118 | c.312T>G | synonymous_variant | 0.22 | rifampicin | Not assoc w R - Interim |
rpoB | 760121 | c.315T>C | synonymous_variant | 0.22 | rifampicin | Not assoc w R - Interim |
rpoB | 760130 | p.Asp108Glu | missense_variant | 0.21 | rifampicin | Uncertain significance |
rpoB | 760139 | c.333A>C | synonymous_variant | 0.2 | rifampicin | |
rpoB | 760142 | c.336C>G | synonymous_variant | 0.19 | rifampicin | |
rpoB | 760184 | c.378A>G | synonymous_variant | 0.18 | rifampicin | Not assoc w R - Interim |
rpoB | 760196 | c.390C>G | synonymous_variant | 0.15 | rifampicin | Not assoc w R - Interim |
rpoB | 760223 | c.417T>C | synonymous_variant | 0.16 | rifampicin | |
rpoB | 760235 | c.429T>C | synonymous_variant | 0.13 | rifampicin | Not assoc w R - Interim |
rpoB | 760358 | c.552C>G | synonymous_variant | 0.16 | rifampicin | |
rpoB | 760361 | c.555T>C | synonymous_variant | 0.16 | rifampicin | Not assoc w R - Interim |
rpoB | 760611 | c.805T>C | synonymous_variant | 0.14 | rifampicin | Not assoc w R - Interim |
rpoB | 760649 | c.843G>C | synonymous_variant | 0.14 | rifampicin | |
rpoB | 760670 | c.864G>C | synonymous_variant | 0.14 | rifampicin | |
rpoB | 760919 | c.1113C>G | synonymous_variant | 0.18 | rifampicin | |
rpoB | 760928 | c.1122G>C | synonymous_variant | 0.18 | rifampicin | Not assoc w R - Interim |
rpoB | 760931 | c.1125C>G | synonymous_variant | 0.19 | rifampicin | |
rpoB | 760946 | c.1140A>G | synonymous_variant | 0.23 | rifampicin | Not assoc w R - Interim |
rpoB | 760970 | c.1164G>C | synonymous_variant | 0.15 | rifampicin | Not assoc w R - Interim |
rpoB | 760973 | c.1167G>C | synonymous_variant | 0.16 | rifampicin | |
rpoB | 760982 | c.1176G>C | synonymous_variant | 0.18 | rifampicin | Not assoc w R - Interim |
rpoB | 760985 | c.1179G>C | synonymous_variant | 0.22 | rifampicin | Not assoc w R - Interim |
rpoB | 760991 | c.1185G>C | synonymous_variant | 0.23 | rifampicin | |
rpoB | 761006 | c.1200C>T | synonymous_variant | 0.16 | rifampicin | |
rpoB | 761015 | c.1209G>C | synonymous_variant | 0.2 | rifampicin | Not assoc w R - Interim |
rpoB | 761057 | c.1251G>C | synonymous_variant | 0.15 | rifampicin | Not assoc w R - Interim |
rpoB | 761207 | c.1401C>T | synonymous_variant | 0.23 | rifampicin | |
rpoB | 761213 | c.1407G>C | synonymous_variant | 0.23 | rifampicin | |
rpoB | 761510 | c.1704T>C | synonymous_variant | 0.19 | rifampicin | |
rpoB | 761537 | c.1731C>G | synonymous_variant | 0.26 | rifampicin | Not assoc w R - Interim |
rpoB | 761573 | c.1767C>G | synonymous_variant | 0.31 | rifampicin | Not assoc w R - Interim |
rpoB | 761579 | c.1773G>C | synonymous_variant | 0.25 | rifampicin | Not assoc w R - Interim |
rpoB | 761582 | c.1776G>A | synonymous_variant | 0.26 | rifampicin | |
rpoB | 761606 | c.1800C>G | synonymous_variant | 0.21 | rifampicin | |
rpoB | 761612 | c.1806G>T | synonymous_variant | 0.16 | rifampicin | Not assoc w R - Interim |
rpoB | 761615 | c.1809A>C | synonymous_variant | 0.15 | rifampicin | Not assoc w R - Interim |
rpoB | 761636 | c.1830G>T | synonymous_variant | 0.15 | rifampicin | Not assoc w R - Interim |
rpoB | 761675 | c.1869G>C | synonymous_variant | 0.14 | rifampicin | |
rpoB | 761753 | c.1947C>G | synonymous_variant | 0.13 | rifampicin | |
rpoB | 761930 | c.2124G>C | synonymous_variant | 0.16 | rifampicin | |
rpoB | 761933 | c.2127G>C | synonymous_variant | 0.16 | rifampicin | |
rpoB | 762029 | c.2223C>G | synonymous_variant | 0.18 | rifampicin | Not assoc w R - Interim |
rpoB | 762047 | c.2241G>A | synonymous_variant | 0.15 | rifampicin | Not assoc w R - Interim |
rpoB | 762053 | c.2247T>C | synonymous_variant | 0.15 | rifampicin | Not assoc w R - Interim |
rpoB | 762056 | c.2250G>A | synonymous_variant | 0.15 | rifampicin | Not assoc w R - Interim |
rpoB | 762062 | c.2256T>C | synonymous_variant | 0.16 | rifampicin | Not assoc w R - Interim |
rpoB | 762065 | c.2259T>C | synonymous_variant | 0.16 | rifampicin | Not assoc w R - Interim |
rpoB | 762083 | c.2277T>C | synonymous_variant | 0.31 | rifampicin | Not assoc w R - Interim |
rpoB | 762086 | c.2280G>C | synonymous_variant | 0.33 | rifampicin | Not assoc w R - Interim |
rpoB | 762101 | c.2295C>G | synonymous_variant | 0.22 | rifampicin | Not assoc w R - Interim |
rpoB | 762114 | p.Ile770Val | missense_variant | 0.23 | rifampicin | Uncertain significance |
rpoB | 762131 | c.2325C>G | synonymous_variant | 0.25 | rifampicin | |
rpoB | 762134 | c.2328C>G | synonymous_variant | 0.25 | rifampicin | Not assoc w R - Interim |
rpoB | 762143 | c.2337T>C | synonymous_variant | 0.19 | rifampicin | |
rpoB | 762149 | c.2343G>C | synonymous_variant | 0.29 | rifampicin | Not assoc w R - Interim |
rpoB | 762185 | c.2379G>C | synonymous_variant | 0.23 | rifampicin | Not assoc w R - Interim |
rpoB | 762221 | c.2415G>A | synonymous_variant | 0.18 | rifampicin | |
rpoB | 762266 | c.2460T>C | synonymous_variant | 0.14 | rifampicin | |
rpoC | 762374 | c.-996G>C | upstream_gene_variant | 0.12 | rifampicin | |
rpoC | 762380 | c.-990T>C | upstream_gene_variant | 0.13 | rifampicin | |
rpoB | 762449 | c.2643C>A | synonymous_variant | 0.14 | rifampicin | Not assoc w R - Interim |
rpoB | 762470 | c.2664G>C | synonymous_variant | 0.18 | rifampicin | Not assoc w R - Interim |
rpoC | 762476 | c.-894C>A | upstream_gene_variant | 0.16 | rifampicin | |
rpoC | 762491 | c.-879T>G | upstream_gene_variant | 0.15 | rifampicin | |
rpoC | 762581 | c.-789T>C | upstream_gene_variant | 0.16 | rifampicin | |
rpoC | 762582 | c.-788T>C | upstream_gene_variant | 0.15 | rifampicin | |
rpoB | 763031 | c.3225T>C | synonymous_variant | 0.47 | rifampicin | Not assoc w R |
rpoB | 763094 | c.3288G>C | synonymous_variant | 0.2 | rifampicin | Not assoc w R - Interim |
rpoC | 763100 | c.-270G>A | upstream_gene_variant | 0.19 | rifampicin | |
rpoB | 763127 | c.3321G>C | synonymous_variant | 0.24 | rifampicin | Not assoc w R - Interim |
rpoB | 763166 | c.3360A>G | synonymous_variant | 0.13 | rifampicin | Not assoc w R - Interim |
rpoC | 763456 | c.87A>G | synonymous_variant | 0.16 | rifampicin | Not assoc w R - Interim |
rpoC | 763468 | c.99G>C | synonymous_variant | 0.13 | rifampicin | Not assoc w R - Interim |
rpoC | 763486 | c.117T>C | synonymous_variant | 0.18 | rifampicin | Not assoc w R - Interim |
rpoC | 763492 | c.123G>C | synonymous_variant | 0.24 | rifampicin | Not assoc w R - Interim |
rpoC | 763528 | c.159G>A | synonymous_variant | 0.14 | rifampicin | Not assoc w R - Interim |
rpoC | 763546 | c.177A>G | synonymous_variant | 0.2 | rifampicin | Not assoc w R - Interim |
rpoC | 763594 | c.225C>T | synonymous_variant | 0.17 | rifampicin | Not assoc w R - Interim |
rpoC | 763884 | p.Ala172Val | missense_variant | 0.47 | rifampicin | Not assoc w R |
rpoC | 763886 | c.517C>A | synonymous_variant | 0.52 | rifampicin | Not assoc w R |
rpoC | 764044 | c.675T>C | synonymous_variant | 0.15 | rifampicin | |
rpoC | 764131 | c.762T>A | synonymous_variant | 0.14 | rifampicin | |
rpoC | 764159 | c.790C>T | synonymous_variant | 0.15 | rifampicin | |
rpoC | 764551 | c.1182G>C | synonymous_variant | 0.18 | rifampicin | |
rpoC | 764566 | c.1197C>G | synonymous_variant | 0.16 | rifampicin | Not assoc w R - Interim |
rpoC | 764575 | c.1206T>G | synonymous_variant | 0.14 | rifampicin | Not assoc w R - Interim |
rpoC | 764581 | c.1212T>C | synonymous_variant | 0.15 | rifampicin | |
rpoC | 764611 | c.1242G>C | synonymous_variant | 0.14 | rifampicin | |
rpoC | 764746 | c.1377G>A | synonymous_variant | 0.16 | rifampicin | |
rpoC | 764752 | c.1383G>C | synonymous_variant | 0.26 | rifampicin | Not assoc w R - Interim |
rpoC | 764758 | c.1389C>G | synonymous_variant | 0.24 | rifampicin | Not assoc w R - Interim |
rpoC | 764764 | c.1395T>C | synonymous_variant | 0.24 | rifampicin | Not assoc w R - Interim |
rpoC | 764791 | c.1422C>G | synonymous_variant | 0.34 | rifampicin | Not assoc w R - Interim |
rpoC | 764809 | c.1440C>T | synonymous_variant | 0.25 | rifampicin | Not assoc w R |
rpoC | 764812 | c.1443C>G | synonymous_variant | 0.23 | rifampicin | |
rpoC | 764815 | c.1446A>G | synonymous_variant | 0.23 | rifampicin | Not assoc w R - Interim |
rpoC | 764824 | c.1455T>C | synonymous_variant | 0.27 | rifampicin | Not assoc w R - Interim |
rpoC | 764858 | c.1489T>C | synonymous_variant | 0.24 | rifampicin | Not assoc w R - Interim |
rpoC | 764875 | c.1506C>G | synonymous_variant | 0.28 | rifampicin | |
rpoC | 764878 | c.1509C>T | synonymous_variant | 0.29 | rifampicin | |
rpoC | 764888 | c.1519T>C | synonymous_variant | 0.24 | rifampicin | Not assoc w R - Interim |
rpoC | 764893 | c.1524T>C | synonymous_variant | 0.28 | rifampicin | |
rpoC | 764911 | c.1542A>G | synonymous_variant | 0.28 | rifampicin | |
rpoC | 764953 | c.1584G>C | synonymous_variant | 0.28 | rifampicin | |
rpoC | 764968 | c.1599T>C | synonymous_variant | 0.19 | rifampicin | Not assoc w R - Interim |
rpoC | 765007 | c.1638T>G | synonymous_variant | 0.16 | rifampicin | Not assoc w R - Interim |
rpoC | 765008 | c.1639T>C | synonymous_variant | 0.15 | rifampicin | Not assoc w R - Interim |
rpoC | 765040 | c.1671T>C | synonymous_variant | 0.13 | rifampicin | Not assoc w R - Interim |
rpoC | 765041 | c.1672T>C | synonymous_variant | 0.13 | rifampicin | Not assoc w R - Interim |
rpoC | 765052 | c.1683C>G | synonymous_variant | 0.13 | rifampicin | Not assoc w R - Interim |
rpoC | 765055 | c.1686C>G | synonymous_variant | 0.14 | rifampicin | Not assoc w R - Interim |
rpoC | 765089 | c.1720T>C | synonymous_variant | 0.13 | rifampicin | Not assoc w R - Interim |
rpoC | 765103 | c.1734G>T | synonymous_variant | 0.14 | rifampicin | |
rpoC | 765499 | c.2130C>G | synonymous_variant | 0.14 | rifampicin | Not assoc w R - Interim |
rpoC | 766003 | c.2634G>C | synonymous_variant | 0.15 | rifampicin | |
rpoC | 766345 | c.2976T>C | synonymous_variant | 0.15 | rifampicin | |
rpoC | 766348 | c.2979A>G | synonymous_variant | 0.15 | rifampicin | Not assoc w R - Interim |
rpoC | 766354 | c.2985C>G | synonymous_variant | 0.16 | rifampicin | |
rpoC | 766381 | c.3012C>T | synonymous_variant | 0.19 | rifampicin | |
rpoC | 766384 | c.3015A>G | synonymous_variant | 0.18 | rifampicin | |
rpoC | 766393 | c.3024C>G | synonymous_variant | 0.17 | rifampicin | |
rpoC | 766408 | c.3039C>T | synonymous_variant | 0.16 | rifampicin | Not assoc w R - Interim |
rpoC | 766426 | c.3057C>T | synonymous_variant | 0.24 | rifampicin | |
rpoC | 766429 | c.3060C>G | synonymous_variant | 0.24 | rifampicin | |
rpoC | 766447 | c.3078T>C | synonymous_variant | 0.13 | rifampicin | |
rpoC | 766456 | c.3087C>G | synonymous_variant | 0.13 | rifampicin | |
rpoC | 766462 | c.3093G>C | synonymous_variant | 0.15 | rifampicin | |
rpoC | 766726 | c.3357T>C | synonymous_variant | 0.17 | rifampicin | |
rpoC | 766738 | c.3369G>T | synonymous_variant | 0.16 | rifampicin | |
rpoC | 766744 | c.3375G>A | synonymous_variant | 0.22 | rifampicin | |
rpoC | 766750 | c.3381C>G | synonymous_variant | 0.15 | rifampicin | |
rpoC | 766753 | c.3384C>T | synonymous_variant | 0.15 | rifampicin | |
rpoC | 766765 | c.3396A>C | synonymous_variant | 0.24 | rifampicin | Not assoc w R - Interim |
rpoC | 766774 | c.3405T>C | synonymous_variant | 0.35 | rifampicin | |
rpoC | 766777 | c.3408C>G | synonymous_variant | 0.35 | rifampicin | |
rpoC | 766798 | c.3429C>G | synonymous_variant | 0.29 | rifampicin | Not assoc w R - Interim |
rpoC | 766801 | c.3432C>G | synonymous_variant | 0.29 | rifampicin | |
rpoC | 766804 | c.3435A>G | synonymous_variant | 0.28 | rifampicin | Not assoc w R - Interim |
rpoC | 766861 | c.3492G>C | synonymous_variant | 0.33 | rifampicin | Not assoc w R - Interim |
rpoC | 766864 | c.3495G>C | synonymous_variant | 0.34 | rifampicin | |
rpoC | 766894 | c.3525T>C | synonymous_variant | 0.23 | rifampicin | |
rpoC | 766895 | c.3526T>C | synonymous_variant | 0.23 | rifampicin | |
rpoC | 766900 | c.3531T>C | synonymous_variant | 0.22 | rifampicin | |
rpoC | 766918 | c.3549C>T | synonymous_variant | 0.37 | rifampicin | Not assoc w R - Interim |
rpoC | 766933 | c.3564A>G | synonymous_variant | 0.31 | rifampicin | |
rpoC | 766945 | c.3576A>G | synonymous_variant | 0.35 | rifampicin | Not assoc w R - Interim |
rpoC | 766963 | c.3594T>C | synonymous_variant | 0.35 | rifampicin | Not assoc w R - Interim |
rpoC | 766972 | c.3603G>C | synonymous_variant | 0.4 | rifampicin | |
rpoC | 766996 | c.3627C>T | synonymous_variant | 0.39 | rifampicin | Not assoc w R - Interim |
rpoC | 767033 | c.3664_3666delTCGinsAGT | synonymous_variant | 0.39 | rifampicin | |
rpoC | 767059 | c.3690T>G | synonymous_variant | 0.35 | rifampicin | Not assoc w R - Interim |
rpoC | 767062 | c.3693C>A | synonymous_variant | 0.35 | rifampicin | |
rpoC | 767098 | c.3729T>C | synonymous_variant | 0.38 | rifampicin | Not assoc w R - Interim |
rpoC | 767119 | c.3750A>G | synonymous_variant | 0.42 | rifampicin | Not assoc w R - Interim |
rpoC | 767134 | c.3765C>A | synonymous_variant | 0.31 | rifampicin | |
rpoC | 767221 | c.3852C>G | synonymous_variant | 0.15 | rifampicin | Not assoc w R - Interim |
rpoC | 767230 | c.3861G>C | synonymous_variant | 0.12 | rifampicin | Not assoc w R - Interim |
rpoC | 767233 | c.3864T>C | synonymous_variant | 0.12 | rifampicin | Not assoc w R - Interim |
mmpL5 | 775639 | p.Ile948Val | missense_variant | 1.0 | bedaquiline | Not assoc w R - Interim |
clofazimine | Not assoc w R | |||||
mmpL5 | 776100 | p.Thr794Ile | missense_variant | 0.44 | bedaquiline | Not assoc w R - Interim |
clofazimine | Not assoc w R | |||||
mmpL5 | 777416 | c.1065G>T | synonymous_variant | 0.48 | bedaquiline | Not assoc w R - Interim |
clofazimine | Not assoc w R - Interim | |||||
rpsL | 781395 | c.-165T>C | upstream_gene_variant | 1.0 | streptomycin | Not assoc w R |
rpsL | 781658 | c.99A>G | synonymous_variant | 0.14 | streptomycin | |
rpsL | 781733 | c.174G>C | synonymous_variant | 0.15 | streptomycin | |
rpsL | 781736 | c.177T>C | synonymous_variant | 0.14 | streptomycin | |
rplC | 800357 | c.-452C>A | upstream_gene_variant | 0.4 | linezolid | Not assoc w R |
rplC | 800498 | c.-311G>A | upstream_gene_variant | 0.15 | linezolid | |
rplC | 800516 | c.-293G>C | upstream_gene_variant | 0.19 | linezolid | |
rplC | 800745 | c.-64_-62delCTCinsTTG | upstream_gene_variant | 0.16 | linezolid | |
rplC | 800759 | c.-50C>T | upstream_gene_variant | 0.13 | linezolid | |
rplC | 800899 | p.Ala31Thr | missense_variant | 0.47 | linezolid | Uncertain significance |
Rv1129c | 1254562 | c.-28T>C | upstream_gene_variant | 0.32 | levofloxacin | Not assoc w R |
moxifloxacin | Not assoc w R | |||||
isoniazid | Not assoc w R | |||||
rifampicin | Not assoc w R | |||||
fbiC | 1304829 | c.1899T>C | synonymous_variant | 0.15 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1304853 | c.1923C>T | synonymous_variant | 0.22 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1304856 | c.1926C>G | synonymous_variant | 0.21 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
sigE | 1365024 | c.612T>C | synonymous_variant | 0.15 | pyrazinamide | |
sigE | 1365027 | c.615C>T | synonymous_variant | 0.15 | pyrazinamide | |
sigE | 1365033 | c.621G>A | synonymous_variant | 0.18 | pyrazinamide | |
embR | 1416628 | c.720C>T | synonymous_variant | 0.38 | ethambutol | |
embR | 1417019 | p.Cys110Tyr | missense_variant | 0.49 | ethambutol | Not assoc w R |
embR | 1417554 | c.-207C>G | upstream_gene_variant | 0.31 | ethambutol | |
embR | 1417793 | c.-446C>T | upstream_gene_variant | 0.18 | ethambutol | |
rrs | 1471659 | n.-187C>T | upstream_gene_variant | 1.0 | kanamycin | |
capreomycin | ||||||
streptomycin | ||||||
amikacin | ||||||
rrs | 1471842 | n.-4T>G | upstream_gene_variant | 0.42 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472108 | n.263C>T | non_coding_transcript_exon_variant | 0.21 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472113 | n.268T>C | non_coding_transcript_exon_variant | 0.16 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472225 | n.380C>A | non_coding_transcript_exon_variant | 0.4 | kanamycin | Uncertain significance |
capreomycin | Not assoc w R | |||||
streptomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472300 | n.455C>T | non_coding_transcript_exon_variant | 0.36 | kanamycin | |
capreomycin | ||||||
streptomycin | ||||||
amikacin | ||||||
rrs | 1472489 | n.644A>T | non_coding_transcript_exon_variant | 0.29 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472755 | n.910G>A | non_coding_transcript_exon_variant | 0.2 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | ||||||
amikacin | Uncertain significance | |||||
rrs | 1472978 | n.1133T>C | non_coding_transcript_exon_variant | 0.25 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1473123 | n.1278delAinsTT | non_coding_transcript_exon_variant | 0.26 | kanamycin | |
capreomycin | ||||||
streptomycin | ||||||
amikacin | ||||||
rrs | 1473290 | n.1445delCinsTT | non_coding_transcript_exon_variant | 0.2 | kanamycin | |
capreomycin | ||||||
streptomycin | ||||||
amikacin | ||||||
rrl | 1473758 | n.101G>T | non_coding_transcript_exon_variant | 0.14 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1473806 | n.149C>T | non_coding_transcript_exon_variant | 0.19 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1473839 | n.182G>T | non_coding_transcript_exon_variant | 0.27 | capreomycin | |
linezolid | ||||||
rrl | 1473876 | n.219G>A | non_coding_transcript_exon_variant | 0.26 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1473899 | n.242A>T | non_coding_transcript_exon_variant | 0.23 | capreomycin | |
linezolid | ||||||
rrl | 1473923 | n.266C>A | non_coding_transcript_exon_variant | 0.16 | capreomycin | |
linezolid | Uncertain significance | |||||
rrl | 1474139 | n.482C>T | non_coding_transcript_exon_variant | 0.16 | capreomycin | |
linezolid | ||||||
rrl | 1474140 | n.483C>T | non_coding_transcript_exon_variant | 0.16 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474151 | n.494C>T | non_coding_transcript_exon_variant | 0.19 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474181 | n.524C>T | non_coding_transcript_exon_variant | 0.27 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1474266 | n.609T>C | non_coding_transcript_exon_variant | 0.26 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474291 | n.634_649delTTTCCTCTCCGGAGGAinsC | non_coding_transcript_exon_variant | 0.15 | capreomycin | |
linezolid | ||||||
rrl | 1474308 | n.651G>T | non_coding_transcript_exon_variant | 0.14 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474310 | n.653T>G | non_coding_transcript_exon_variant | 0.14 | capreomycin | |
linezolid | ||||||
rrl | 1474362 | n.705A>G | non_coding_transcript_exon_variant | 0.27 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474412 | n.756_768delACCCACACGCGCA | non_coding_transcript_exon_variant | 0.14 | capreomycin | |
linezolid | ||||||
rrl | 1474428 | n.771C>T | non_coding_transcript_exon_variant | 0.13 | capreomycin | |
linezolid | ||||||
rrl | 1474429 | n.772G>C | non_coding_transcript_exon_variant | 0.13 | capreomycin | |
linezolid | ||||||
rrl | 1474431 | n.774G>C | non_coding_transcript_exon_variant | 0.13 | capreomycin | |
linezolid | ||||||
rrl | 1474447 | n.790G>A | non_coding_transcript_exon_variant | 0.17 | capreomycin | |
linezolid | ||||||
rrl | 1474639 | n.982G>A | non_coding_transcript_exon_variant | 0.37 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474716 | n.1059A>C | non_coding_transcript_exon_variant | 0.32 | capreomycin | |
linezolid | ||||||
rrl | 1474794 | n.1137C>A | non_coding_transcript_exon_variant | 0.31 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474812 | n.1155G>A | non_coding_transcript_exon_variant | 0.33 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474831 | n.1174A>G | non_coding_transcript_exon_variant | 0.36 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1475355 | n.1698C>T | non_coding_transcript_exon_variant | 0.26 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1475369 | n.1712G>C | non_coding_transcript_exon_variant | 0.33 | capreomycin | |
linezolid | ||||||
rrl | 1475402 | n.1745C>T | non_coding_transcript_exon_variant | 0.3 | capreomycin | |
linezolid | ||||||
rrl | 1475429 | n.1772G>A | non_coding_transcript_exon_variant | 0.27 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1475479 | n.1822C>T | non_coding_transcript_exon_variant | 0.31 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1475480 | n.1823A>T | non_coding_transcript_exon_variant | 0.3 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1475505 | n.1848G>A | non_coding_transcript_exon_variant | 0.38 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1475526 | n.1869C>A | non_coding_transcript_exon_variant | 0.29 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1475573 | n.1916G>A | non_coding_transcript_exon_variant | 0.17 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1476214 | n.2557G>T | non_coding_transcript_exon_variant | 0.28 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476215 | n.2558C>T | non_coding_transcript_exon_variant | 0.29 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476297 | n.2640C>T | non_coding_transcript_exon_variant | 0.37 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476299 | n.2642C>T | non_coding_transcript_exon_variant | 0.37 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476580 | n.2923G>A | non_coding_transcript_exon_variant | 0.33 | capreomycin | |
linezolid | ||||||
rrl | 1476597 | n.2940G>A | non_coding_transcript_exon_variant | 0.28 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1476608 | n.2951C>T | non_coding_transcript_exon_variant | 0.26 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476619 | n.2962C>T | non_coding_transcript_exon_variant | 0.23 | capreomycin | Not assoc w R |
linezolid | Uncertain significance | |||||
rrl | 1476628 | n.2971T>A | non_coding_transcript_exon_variant | 0.19 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
inhA | 1674114 | c.-88T>G | upstream_gene_variant | 0.21 | isoniazid | |
ethionamide | ||||||
inhA | 1674117 | c.-85C>G | upstream_gene_variant | 0.21 | isoniazid | |
ethionamide | ||||||
inhA | 1674503 | p.Thr101Ser | missense_variant | 0.14 | isoniazid | |
ethionamide | ||||||
inhA | 1674546 | c.345T>C | synonymous_variant | 0.14 | isoniazid | |
ethionamide | ||||||
inhA | 1674669 | c.468G>C | synonymous_variant | 0.14 | isoniazid | |
ethionamide | ||||||
inhA | 1674718 | c.517A>C | synonymous_variant | 0.15 | isoniazid | |
ethionamide | ||||||
rpsA | 1833661 | c.120A>G | synonymous_variant | 0.28 | pyrazinamide | |
rpsA | 1833664 | c.123C>A | synonymous_variant | 0.28 | pyrazinamide | |
rpsA | 1833724 | c.183C>G | synonymous_variant | 0.28 | pyrazinamide | |
rpsA | 1833727 | c.186G>C | synonymous_variant | 0.28 | pyrazinamide | |
rpsA | 1833742 | c.201A>G | synonymous_variant | 0.28 | pyrazinamide | |
rpsA | 1833745 | c.204G>C | synonymous_variant | 0.27 | pyrazinamide | |
rpsA | 1833802 | c.261A>G | synonymous_variant | 0.32 | pyrazinamide | |
rpsA | 1833811 | c.270G>T | synonymous_variant | 0.33 | pyrazinamide | |
rpsA | 1833820 | c.279G>A | synonymous_variant | 0.37 | pyrazinamide | |
rpsA | 1833856 | c.315A>G | synonymous_variant | 0.37 | pyrazinamide | |
rpsA | 1833859 | c.318C>T | synonymous_variant | 0.38 | pyrazinamide | |
rpsA | 1833874 | c.333T>C | synonymous_variant | 0.33 | pyrazinamide | |
rpsA | 1833894 | p.Ala118Glu | missense_variant | 0.37 | pyrazinamide | |
rpsA | 1833928 | c.387G>C | synonymous_variant | 0.34 | pyrazinamide | |
rpsA | 1833949 | c.408T>C | synonymous_variant | 0.28 | pyrazinamide | |
rpsA | 1833976 | c.435C>T | synonymous_variant | 0.24 | pyrazinamide | |
rpsA | 1833979 | c.438T>C | synonymous_variant | 0.24 | pyrazinamide | |
rpsA | 1834000 | c.459G>C | synonymous_variant | 0.29 | pyrazinamide | |
rpsA | 1834012 | c.471G>C | synonymous_variant | 0.22 | pyrazinamide | |
rpsA | 1834015 | c.474G>C | synonymous_variant | 0.21 | pyrazinamide | |
rpsA | 1834030 | c.489C>G | synonymous_variant | 0.25 | pyrazinamide | |
rpsA | 1834051 | c.510G>A | synonymous_variant | 0.25 | pyrazinamide | |
rpsA | 1834093 | c.552G>C | synonymous_variant | 0.34 | pyrazinamide | |
rpsA | 1834102 | c.561T>G | synonymous_variant | 0.29 | pyrazinamide | |
rpsA | 1834135 | c.594G>A | synonymous_variant | 0.21 | pyrazinamide | |
rpsA | 1834144 | c.603G>A | synonymous_variant | 0.19 | pyrazinamide | Not assoc w R - Interim |
rpsA | 1834150 | c.609G>C | synonymous_variant | 0.15 | pyrazinamide | |
rpsA | 1834153 | c.612T>C | synonymous_variant | 0.15 | pyrazinamide | |
rpsA | 1834154 | p.Asn205Gln | missense_variant | 0.15 | pyrazinamide | |
rpsA | 1834157 | c.616T>C | synonymous_variant | 0.15 | pyrazinamide | |
rpsA | 1834162 | c.621A>G | synonymous_variant | 0.14 | pyrazinamide | Not assoc w R - Interim |
rpsA | 1834165 | c.624A>G | synonymous_variant | 0.15 | pyrazinamide | |
rpsA | 1834177 | c.636A>C | synonymous_variant | 0.19 | pyrazinamide | Not assoc w R - Interim |
rpsA | 1834186 | c.645C>G | synonymous_variant | 0.25 | pyrazinamide | |
rpsA | 1834189 | c.648G>C | synonymous_variant | 0.25 | pyrazinamide | |
rpsA | 1834213 | c.672G>C | synonymous_variant | 0.14 | pyrazinamide | |
rpsA | 1834222 | c.681T>C | synonymous_variant | 0.15 | pyrazinamide | |
rpsA | 1834231 | c.690T>G | synonymous_variant | 0.14 | pyrazinamide | |
rpsA | 1834297 | c.756C>G | synonymous_variant | 0.22 | pyrazinamide | |
rpsA | 1834303 | c.762T>C | synonymous_variant | 0.24 | pyrazinamide | |
rpsA | 1834306 | c.765T>C | synonymous_variant | 0.22 | pyrazinamide | |
rpsA | 1834451 | c.910T>C | synonymous_variant | 0.21 | pyrazinamide | |
rpsA | 1834456 | c.915T>G | synonymous_variant | 0.21 | pyrazinamide | |
rpsA | 1834459 | c.918G>C | synonymous_variant | 0.22 | pyrazinamide | |
rpsA | 1834468 | c.927A>G | synonymous_variant | 0.21 | pyrazinamide | |
rpsA | 1834477 | c.936C>T | synonymous_variant | 0.18 | pyrazinamide | Not assoc w R - Interim |
rpsA | 1834489 | c.948T>C | synonymous_variant | 0.26 | pyrazinamide | |
rpsA | 1834498 | c.957C>T | synonymous_variant | 0.27 | pyrazinamide | |
rpsA | 1834528 | c.987T>C | synonymous_variant | 0.35 | pyrazinamide | |
rpsA | 1834546 | c.1005T>C | synonymous_variant | 0.37 | pyrazinamide | |
rpsA | 1834600 | c.1059G>C | synonymous_variant | 0.25 | pyrazinamide | |
rpsA | 1834606 | c.1065C>T | synonymous_variant | 0.27 | pyrazinamide | |
rpsA | 1834609 | c.1068T>C | synonymous_variant | 0.26 | pyrazinamide | |
rpsA | 1834633 | c.1092A>G | synonymous_variant | 0.26 | pyrazinamide | |
rpsA | 1834639 | c.1098T>C | synonymous_variant | 0.26 | pyrazinamide | |
rpsA | 1834654 | p.Glu371Asp | missense_variant | 0.26 | pyrazinamide | |
rpsA | 1834669 | c.1128G>C | synonymous_variant | 0.28 | pyrazinamide | |
rpsA | 1834690 | c.1149T>C | synonymous_variant | 0.19 | pyrazinamide | |
tsnR | 1853477 | c.-129T>C | upstream_gene_variant | 0.16 | linezolid | |
tsnR | 1853974 | c.369C>T | synonymous_variant | 0.36 | linezolid | Not assoc w R |
tsnR | 1854300 | p.Leu232Pro | missense_variant | 1.0 | linezolid | Not assoc w R |
tlyA | 1917972 | c.33A>G | synonymous_variant | 1.0 | capreomycin | Not assoc w R |
bacA | 2062922 | p.Ile603Val | missense_variant | 0.44 | kanamycin | Not assoc w R |
capreomycin | Not assoc w R | |||||
streptomycin | Not assoc w R | |||||
amikacin | Not assoc w R | |||||
ndh | 2102134 | c.909C>G | synonymous_variant | 0.14 | isoniazid | |
delamanid | ||||||
ethionamide | ||||||
ndh | 2102990 | p.Val18Ala | missense_variant | 0.61 | isoniazid | Not assoc w R |
delamanid | Uncertain significance | |||||
ethionamide | Uncertain significance | |||||
katG | 2154724 | p.Arg463Leu | missense_variant | 0.24 | isoniazid | Not assoc w R |
PPE35 | 2167926 | p.Leu896Ser | missense_variant | 0.23 | pyrazinamide | Not assoc w R |
PPE35 | 2168479 | p.Thr712Pro | missense_variant | 0.62 | pyrazinamide | Not assoc w R |
PPE35 | 2169840 | p.Gly258Asp | missense_variant | 0.72 | pyrazinamide | Not assoc w R |
Rv1979c | 2222308 | p.Asp286Gly | missense_variant | 0.37 | bedaquiline | Not assoc w R - Interim |
clofazimine | Not assoc w R | |||||
Rv1979c | 2223293 | c.-129A>G | upstream_gene_variant | 1.0 | bedaquiline | Not assoc w R - Interim |
clofazimine | Not assoc w R | |||||
kasA | 2517941 | c.-174C>G | upstream_gene_variant | 0.15 | isoniazid | |
kasA | 2517950 | c.-165C>G | upstream_gene_variant | 0.15 | isoniazid | |
kasA | 2518019 | c.-96A>G | upstream_gene_variant | 0.15 | isoniazid | |
kasA | 2518132 | c.18C>T | synonymous_variant | 0.39 | isoniazid | |
kasA | 2518519 | c.405G>C | synonymous_variant | 0.15 | isoniazid | |
kasA | 2518528 | c.414C>G | synonymous_variant | 0.14 | isoniazid | |
kasA | 2518534 | c.420G>C | synonymous_variant | 0.13 | isoniazid | |
kasA | 2518561 | c.447T>C | synonymous_variant | 0.12 | isoniazid | |
kasA | 2518843 | c.729T>C | synonymous_variant | 0.17 | isoniazid | |
kasA | 2518847 | p.Leu245Met | missense_variant | 0.14 | isoniazid | |
kasA | 2518853 | p.Leu247Ile | missense_variant | 0.14 | isoniazid | |
ahpC | 2726051 | c.-142G>A | upstream_gene_variant | 0.31 | isoniazid | |
ahpC | 2726405 | c.213C>G | synonymous_variant | 0.17 | isoniazid | |
ahpC | 2726408 | c.216T>C | synonymous_variant | 0.18 | isoniazid | |
folC | 2747506 | c.93G>A | synonymous_variant | 0.16 | para-aminosalicylic_acid | |
folC | 2747509 | c.90T>C | synonymous_variant | 0.16 | para-aminosalicylic_acid | |
Rv2477c | 2782483 | c.1560G>C | synonymous_variant | 0.14 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2783512 | c.531A>G | synonymous_variant | 0.16 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2783515 | c.528C>G | synonymous_variant | 0.16 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2783914 | c.129T>C | synonymous_variant | 0.12 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2783917 | c.126C>G | synonymous_variant | 0.13 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2783992 | c.51T>C | synonymous_variant | 0.16 | kanamycin | Not assoc w R - Interim |
levofloxacin | Not assoc w R - Interim | |||||
moxifloxacin | ||||||
streptomycin | Not assoc w R - Interim | |||||
rifampicin | Not assoc w R - Interim | |||||
ethambutol | Not assoc w R - Interim | |||||
amikacin | ||||||
Rv2752c | 3064852 | p.Met447Thr | missense_variant | 0.53 | levofloxacin | Uncertain significance |
moxifloxacin | Uncertain significance | |||||
isoniazid | Uncertain significance | |||||
rifampicin | Uncertain significance | |||||
ethambutol | Uncertain significance | |||||
Rv2752c | 3066855 | c.-664T>C | upstream_gene_variant | 0.17 | levofloxacin | |
moxifloxacin | ||||||
isoniazid | ||||||
rifampicin | ||||||
ethambutol | ||||||
thyX | 3067355 | c.591A>C | synonymous_variant | 0.16 | para-aminosalicylic_acid | |
thyX | 3067385 | c.561C>G | synonymous_variant | 0.21 | para-aminosalicylic_acid | |
thyX | 3067394 | c.552G>C | synonymous_variant | 0.17 | para-aminosalicylic_acid | |
thyX | 3067631 | c.315C>G | synonymous_variant | 0.17 | para-aminosalicylic_acid | |
thyX | 3067640 | c.306G>C | synonymous_variant | 0.13 | para-aminosalicylic_acid | |
ald | 3086788 | c.-32T>C | upstream_gene_variant | 1.0 | cycloserine | |
Rv3083 | 3448608 | c.105G>A | synonymous_variant | 0.63 | ethionamide | Not assoc w R - Interim |
Rv3083 | 3448714 | p.Asp71His | missense_variant | 0.4 | ethionamide | Uncertain significance |
whiB7 | 3568779 | c.-100T>C | upstream_gene_variant | 0.54 | kanamycin | Not assoc w R |
amikacin | Not assoc w R | |||||
streptomycin | Not assoc w R | |||||
Rv3236c | 3612665 | p.Val151Ala | missense_variant | 0.5 | pyrazinamide | Not assoc w R |
lpqB | 3623366 | c.1545T>C | synonymous_variant | 0.2 | rifampicin | |
bedaquiline | ||||||
lpqB | 3623375 | c.1536T>C | synonymous_variant | 0.18 | rifampicin | |
bedaquiline | ||||||
lpqB | 3623380 | p.Ala511Thr | missense_variant | 0.18 | rifampicin | |
bedaquiline | ||||||
lpqB | 3623388 | p.Thr508Asn | missense_variant | 0.14 | rifampicin | |
bedaquiline | ||||||
lpqB | 3623393 | c.1518A>C | synonymous_variant | 0.14 | rifampicin | |
bedaquiline | ||||||
lpqB | 3623699 | c.1212C>G | synonymous_variant | 0.21 | rifampicin | |
bedaquiline | ||||||
lpqB | 3623708 | c.1203C>T | synonymous_variant | 0.25 | rifampicin | |
bedaquiline | ||||||
lpqB | 3623736 | p.Ser392Asn | missense_variant | 0.15 | rifampicin | |
bedaquiline | ||||||
lpqB | 3624374 | c.537G>C | synonymous_variant | 0.13 | rifampicin | |
bedaquiline | ||||||
lpqB | 3624380 | c.531G>A | synonymous_variant | 0.16 | rifampicin | |
bedaquiline | ||||||
lpqB | 3624486 | p.Asp142Gly | missense_variant | 0.42 | rifampicin | Not assoc w R |
bedaquiline | Uncertain significance | |||||
lpqB | 3624728 | c.183C>T | synonymous_variant | 0.14 | rifampicin | |
bedaquiline | ||||||
lpqB | 3624734 | c.177A>C | synonymous_variant | 0.13 | rifampicin | |
bedaquiline | ||||||
lpqB | 3624749 | c.162G>A | synonymous_variant | 0.13 | rifampicin | Not assoc w R - Interim |
bedaquiline | ||||||
lpqB | 3624755 | c.156A>G | synonymous_variant | 0.15 | rifampicin | Not assoc w R - Interim |
bedaquiline | ||||||
lpqB | 3624776 | c.135T>C | synonymous_variant | 0.14 | rifampicin | |
bedaquiline | ||||||
mtrB | 3625065 | p.Met517Leu | missense_variant | 1.0 | rifampicin | Not assoc w R |
bedaquiline | Uncertain significance | |||||
mtrB | 3625222 | c.1392T>C | synonymous_variant | 0.18 | rifampicin | Not assoc w R - Interim |
bedaquiline | ||||||
lpqB | 3625240 | c.-330T>C | upstream_gene_variant | 0.12 | rifampicin | |
bedaquiline | ||||||
lpqB | 3625243 | c.-333T>C | upstream_gene_variant | 0.13 | rifampicin | |
bedaquiline | ||||||
lpqB | 3625246 | c.-336G>A | upstream_gene_variant | 0.13 | rifampicin | |
bedaquiline | ||||||
lpqB | 3625255 | c.-345T>C | upstream_gene_variant | 0.13 | rifampicin | |
bedaquiline | ||||||
mtrB | 3625267 | c.1347T>C | synonymous_variant | 0.15 | rifampicin | Not assoc w R - Interim |
bedaquiline | ||||||
lpqB | 3625270 | c.-360G>C | upstream_gene_variant | 0.15 | rifampicin | |
bedaquiline | ||||||
lpqB | 3625282 | c.-372C>G | upstream_gene_variant | 0.2 | rifampicin | |
bedaquiline | ||||||
lpqB | 3625285 | c.-375G>C | upstream_gene_variant | 0.21 | rifampicin | |
bedaquiline | ||||||
lpqB | 3625291 | c.-381A>G | upstream_gene_variant | 0.23 | rifampicin | |
bedaquiline | ||||||
mtrB | 3625321 | c.1293A>G | synonymous_variant | 0.2 | rifampicin | Not assoc w R - Interim |
bedaquiline | Not assoc w R - Interim | |||||
lpqB | 3625327 | c.-417A>G | upstream_gene_variant | 0.21 | rifampicin | |
bedaquiline | ||||||
lpqB | 3625345 | c.-435T>C | upstream_gene_variant | 0.17 | rifampicin | |
bedaquiline | ||||||
lpqB | 3625357 | c.-447T>C | upstream_gene_variant | 0.13 | rifampicin | |
bedaquiline | ||||||
lpqB | 3625366 | c.-456C>T | upstream_gene_variant | 0.2 | rifampicin | |
bedaquiline | ||||||
lpqB | 3625369 | c.-459G>C | upstream_gene_variant | 0.2 | rifampicin | |
bedaquiline | ||||||
lpqB | 3625510 | c.-600T>C | upstream_gene_variant | 0.18 | rifampicin | |
bedaquiline | ||||||
lpqB | 3625513 | c.-603G>C | upstream_gene_variant | 0.18 | rifampicin | |
bedaquiline | ||||||
lpqB | 3625518 | c.-608T>C | upstream_gene_variant | 0.13 | rifampicin | |
bedaquiline | ||||||
lpqB | 3625528 | c.-618G>T | upstream_gene_variant | 0.15 | rifampicin | |
bedaquiline | ||||||
lpqB | 3625537 | c.-627T>C | upstream_gene_variant | 0.17 | rifampicin | |
bedaquiline | ||||||
lpqB | 3625543 | c.-633G>C | upstream_gene_variant | 0.2 | rifampicin | |
bedaquiline | ||||||
lpqB | 3625555 | c.-645G>C | upstream_gene_variant | 0.17 | rifampicin | |
bedaquiline | ||||||
mtrB | 3625569 | c.1045T>C | synonymous_variant | 0.13 | rifampicin | Not assoc w R - Interim |
bedaquiline | ||||||
lpqB | 3625579 | c.-669A>C | upstream_gene_variant | 0.14 | rifampicin | |
bedaquiline | ||||||
mtrB | 3625656 | c.958T>C | synonymous_variant | 0.25 | rifampicin | Not assoc w R - Interim |
bedaquiline | Not assoc w R - Interim | |||||
lpqB | 3625663 | c.-753G>C | upstream_gene_variant | 0.21 | rifampicin | |
bedaquiline | ||||||
lpqB | 3625687 | c.-777G>C | upstream_gene_variant | 0.21 | rifampicin | |
bedaquiline | ||||||
lpqB | 3625690 | c.-780T>G | upstream_gene_variant | 0.2 | rifampicin | |
bedaquiline | ||||||
lpqB | 3625726 | c.-816G>A | upstream_gene_variant | 0.2 | rifampicin | |
bedaquiline | ||||||
mtrB | 3625729 | c.885A>G | synonymous_variant | 0.2 | rifampicin | Not assoc w R - Interim |
bedaquiline | ||||||
mtrB | 3625747 | c.867G>C | synonymous_variant | 0.23 | rifampicin | Not assoc w R - Interim |
bedaquiline | ||||||
mtrB | 3625755 | p.Ala287Thr | missense_variant | 0.16 | rifampicin | Uncertain significance |
bedaquiline | ||||||
mtrB | 3625762 | c.852A>G | synonymous_variant | 0.14 | rifampicin | Not assoc w R - Interim |
bedaquiline | ||||||
lpqB | 3625786 | c.-876C>T | upstream_gene_variant | 0.17 | rifampicin | |
bedaquiline | ||||||
mtrB | 3625806 | c.808A>C | synonymous_variant | 0.17 | rifampicin | Not assoc w R - Interim |
bedaquiline | ||||||
mtrB | 3625807 | c.807C>G | synonymous_variant | 0.14 | rifampicin | Not assoc w R - Interim |
bedaquiline | ||||||
mtrB | 3625927 | c.687T>C | synonymous_variant | 0.15 | rifampicin | |
bedaquiline | ||||||
mtrB | 3625933 | c.681C>G | synonymous_variant | 0.14 | rifampicin | |
bedaquiline | ||||||
mtrB | 3625936 | c.678C>G | synonymous_variant | 0.14 | rifampicin | Not assoc w R - Interim |
bedaquiline | ||||||
mtrB | 3625993 | c.621G>C | synonymous_variant | 0.16 | rifampicin | |
bedaquiline | ||||||
mtrB | 3625996 | c.618C>A | synonymous_variant | 0.15 | rifampicin | |
bedaquiline | ||||||
mtrB | 3625999 | c.615A>G | synonymous_variant | 0.14 | rifampicin | |
bedaquiline | ||||||
mtrB | 3626006 | p.Ser203Asn | missense_variant | 0.13 | rifampicin | |
bedaquiline | ||||||
mtrB | 3626017 | c.597T>C | synonymous_variant | 0.22 | rifampicin | |
bedaquiline | ||||||
mtrB | 3626025 | c.589C>T | synonymous_variant | 0.36 | rifampicin | Not assoc w R - Interim |
bedaquiline | Not assoc w R - Interim | |||||
mtrB | 3626029 | c.585A>G | synonymous_variant | 0.2 | rifampicin | |
bedaquiline | ||||||
mtrB | 3626041 | c.573C>G | synonymous_variant | 0.25 | rifampicin | |
bedaquiline | ||||||
mtrB | 3626054 | p.Leu187Ser | missense_variant | 0.22 | rifampicin | |
bedaquiline | ||||||
mtrB | 3626062 | c.552T>G | synonymous_variant | 0.21 | rifampicin | |
bedaquiline | ||||||
mtrB | 3626070 | p.Ile182Val | missense_variant | 0.2 | rifampicin | |
bedaquiline | ||||||
mtrB | 3626077 | c.537C>G | synonymous_variant | 0.26 | rifampicin | |
bedaquiline | ||||||
mtrB | 3626083 | c.531G>C | synonymous_variant | 0.3 | rifampicin | |
bedaquiline | ||||||
mtrB | 3626092 | c.522T>C | synonymous_variant | 0.29 | rifampicin | |
bedaquiline | ||||||
mtrB | 3626095 | p.Glu173Asp | missense_variant | 0.32 | rifampicin | |
bedaquiline | ||||||
mtrB | 3626101 | p.Gln171His | missense_variant | 0.31 | rifampicin | |
bedaquiline | ||||||
mtrB | 3626110 | c.504C>G | synonymous_variant | 0.26 | rifampicin | |
bedaquiline | ||||||
mtrB | 3626125 | c.489C>T | synonymous_variant | 0.2 | rifampicin | |
bedaquiline | ||||||
mtrB | 3626131 | c.483G>C | synonymous_variant | 0.2 | rifampicin | |
bedaquiline | ||||||
mtrB | 3626137 | c.477G>A | synonymous_variant | 0.19 | rifampicin | |
bedaquiline | ||||||
mtrB | 3626158 | c.456C>T | synonymous_variant | 0.12 | rifampicin | |
bedaquiline | ||||||
mtrB | 3626221 | c.393G>C | synonymous_variant | 0.16 | rifampicin | |
bedaquiline | ||||||
mtrB | 3626284 | c.330T>G | synonymous_variant | 0.16 | rifampicin | Not assoc w R - Interim |
bedaquiline | Not assoc w R - Interim | |||||
mtrB | 3626293 | c.321G>A | synonymous_variant | 0.17 | rifampicin | |
bedaquiline | ||||||
mtrB | 3626296 | c.318T>G | synonymous_variant | 0.17 | rifampicin | |
bedaquiline | ||||||
mtrB | 3626299 | c.315G>A | synonymous_variant | 0.16 | rifampicin | |
bedaquiline | ||||||
mtrB | 3626357 | p.Thr86Asn | missense_variant | 0.15 | rifampicin | |
bedaquiline | ||||||
mtrB | 3626362 | c.252A>G | synonymous_variant | 0.15 | rifampicin | Not assoc w R - Interim |
bedaquiline | ||||||
mtrB | 3626437 | c.177T>C | synonymous_variant | 0.14 | rifampicin | |
bedaquiline | ||||||
mtrB | 3626440 | c.174C>T | synonymous_variant | 0.13 | rifampicin | Not assoc w R - Interim |
bedaquiline | Not assoc w R - Interim | |||||
mtrB | 3626705 | c.-92G>T | upstream_gene_variant | 0.13 | rifampicin | |
bedaquiline | ||||||
mtrB | 3626711 | c.-98T>C | upstream_gene_variant | 0.15 | rifampicin | |
bedaquiline | ||||||
mtrA | 3626723 | c.627C>T | synonymous_variant | 0.32 | rifampicin | Not assoc w R - Interim |
bedaquiline | ||||||
mtrB | 3626744 | c.-131G>C | upstream_gene_variant | 0.26 | rifampicin | |
bedaquiline | ||||||
mtrB | 3626750 | c.-137T>C | upstream_gene_variant | 0.27 | rifampicin | |
bedaquiline | ||||||
mtrA | 3626759 | c.591T>C | synonymous_variant | 0.29 | rifampicin | Not assoc w R - Interim |
bedaquiline | ||||||
mtrB | 3626774 | c.-163_-161delAGGinsCGT | upstream_gene_variant | 0.22 | rifampicin | |
bedaquiline | ||||||
mtrB | 3626780 | c.-167T>C | upstream_gene_variant | 0.22 | rifampicin | |
bedaquiline | ||||||
mtrB | 3626783 | c.-170C>G | upstream_gene_variant | 0.22 | rifampicin | |
bedaquiline | ||||||
mtrA | 3626786 | c.564A>G | synonymous_variant | 0.23 | rifampicin | Not assoc w R - Interim |
bedaquiline | ||||||
mtrB | 3626798 | c.-185T>C | upstream_gene_variant | 0.26 | rifampicin | |
bedaquiline | ||||||
mtrB | 3626804 | c.-191A>C | upstream_gene_variant | 0.26 | rifampicin | |
bedaquiline | ||||||
mtrB | 3626843 | c.-230G>C | upstream_gene_variant | 0.27 | rifampicin | |
bedaquiline | ||||||
mtrA | 3626846 | c.504G>A | synonymous_variant | 0.27 | rifampicin | Not assoc w R - Interim |
bedaquiline | ||||||
mtrB | 3626849 | c.-236C>T | upstream_gene_variant | 0.28 | rifampicin | |
bedaquiline | ||||||
mtrB | 3626858 | c.-245A>G | upstream_gene_variant | 0.29 | rifampicin | |
bedaquiline | ||||||
mtrB | 3626866 | c.-253T>C | upstream_gene_variant | 0.31 | rifampicin | |
bedaquiline | ||||||
mtrB | 3626885 | c.-272A>G | upstream_gene_variant | 0.3 | rifampicin | |
bedaquiline | ||||||
mtrB | 3626890 | c.-277T>C | upstream_gene_variant | 0.31 | rifampicin | |
bedaquiline | ||||||
mtrA | 3626912 | c.438T>C | synonymous_variant | 0.31 | rifampicin | Not assoc w R - Interim |
bedaquiline | ||||||
mtrB | 3626930 | c.-317A>G | upstream_gene_variant | 0.33 | rifampicin | |
bedaquiline | ||||||
mtrA | 3626939 | p.Glu137Asp | missense_variant | 0.34 | rifampicin | |
bedaquiline | ||||||
mtrB | 3626942 | c.-329A>C | upstream_gene_variant | 0.35 | rifampicin | |
bedaquiline | ||||||
mtrB | 3626969 | c.-356C>G | upstream_gene_variant | 0.38 | rifampicin | |
bedaquiline | ||||||
mtrB | 3626972 | c.-359A>G | upstream_gene_variant | 0.38 | rifampicin | |
bedaquiline | ||||||
mtrB | 3626993 | c.-380G>C | upstream_gene_variant | 0.3 | rifampicin | |
bedaquiline | ||||||
mtrB | 3627011 | c.-398T>C | upstream_gene_variant | 0.25 | rifampicin | |
bedaquiline | ||||||
mtrB | 3627059 | c.-446G>C | upstream_gene_variant | 0.26 | rifampicin | |
bedaquiline | ||||||
mtrA | 3627068 | c.282T>C | synonymous_variant | 0.2 | rifampicin | Not assoc w R - Interim |
bedaquiline | ||||||
mtrB | 3627071 | c.-458G>C | upstream_gene_variant | 0.2 | rifampicin | |
bedaquiline | ||||||
mtrA | 3627080 | c.270T>C | synonymous_variant | 0.17 | rifampicin | Not assoc w R - Interim |
bedaquiline | ||||||
mtrA | 3627098 | c.252A>C | synonymous_variant | 0.13 | rifampicin | Not assoc w R - Interim |
bedaquiline | ||||||
fbiA | 3640365 | c.-178C>G | upstream_gene_variant | 0.16 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiB | 3641274 | c.-261G>C | upstream_gene_variant | 0.16 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiB | 3641277 | c.-258G>C | upstream_gene_variant | 0.16 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
rpoA | 3877839 | c.669G>C | synonymous_variant | 0.16 | rifampicin | Not assoc w R - Interim |
rpoA | 3877842 | c.666A>G | synonymous_variant | 0.16 | rifampicin | |
rpoA | 3877848 | c.660C>T | synonymous_variant | 0.15 | rifampicin | Not assoc w R - Interim |
rpoA | 3877857 | c.651G>A | synonymous_variant | 0.14 | rifampicin | |
rpoA | 3877962 | c.546G>T | synonymous_variant | 0.14 | rifampicin | Not assoc w R - Interim |
rpoA | 3878271 | c.237T>C | synonymous_variant | 0.19 | rifampicin | Not assoc w R - Interim |
rpoA | 3878283 | p.Glu75Asp | missense_variant | 0.16 | rifampicin | Uncertain significance |
rpoA | 3878298 | c.210A>G | synonymous_variant | 0.14 | rifampicin | Not assoc w R - Interim |
rpoA | 3878301 | c.207C>G | synonymous_variant | 0.14 | rifampicin | Not assoc w R - Interim |
rpoA | 3878304 | c.204G>C | synonymous_variant | 0.14 | rifampicin | |
rpoA | 3878313 | c.195G>C | synonymous_variant | 0.15 | rifampicin | Not assoc w R - Interim |
rpoA | 3878322 | c.186A>G | synonymous_variant | 0.13 | rifampicin | Not assoc w R - Interim |
rpoA | 3878364 | c.144A>C | synonymous_variant | 0.14 | rifampicin | |
rpoA | 3878370 | c.138T>C | synonymous_variant | 0.12 | rifampicin | |
clpC1 | 4038596 | c.2109A>G | synonymous_variant | 0.14 | pyrazinamide | |
clpC1 | 4038623 | c.2082A>G | synonymous_variant | 0.21 | pyrazinamide | |
clpC1 | 4038645 | p.Glu687Ala | missense_variant | 0.15 | pyrazinamide | |
clpC1 | 4038713 | c.1992T>C | synonymous_variant | 0.14 | pyrazinamide | |
clpC1 | 4038838 | c.1867C>T | synonymous_variant | 0.15 | pyrazinamide | |
clpC1 | 4038878 | c.1827A>G | synonymous_variant | 0.15 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4038881 | c.1824C>T | synonymous_variant | 0.16 | pyrazinamide | |
clpC1 | 4038890 | c.1815G>A | synonymous_variant | 0.17 | pyrazinamide | |
clpC1 | 4038923 | c.1782A>G | synonymous_variant | 0.14 | pyrazinamide | |
clpC1 | 4038941 | c.1764G>C | synonymous_variant | 0.16 | pyrazinamide | |
clpC1 | 4038953 | c.1752A>G | synonymous_variant | 0.14 | pyrazinamide | |
clpC1 | 4038956 | c.1749T>C | synonymous_variant | 0.16 | pyrazinamide | |
clpC1 | 4039022 | c.1683A>G | synonymous_variant | 0.17 | pyrazinamide | |
clpC1 | 4039079 | c.1626C>G | synonymous_variant | 0.15 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4039338 | p.Thr456Gln | missense_variant | 0.15 | pyrazinamide | |
clpC1 | 4039352 | c.1353C>G | synonymous_variant | 0.21 | pyrazinamide | |
clpC1 | 4039355 | c.1350G>C | synonymous_variant | 0.21 | pyrazinamide | |
clpC1 | 4039634 | c.1071G>A | synonymous_variant | 0.18 | pyrazinamide | |
clpC1 | 4039898 | c.807C>G | synonymous_variant | 0.24 | pyrazinamide | |
clpC1 | 4040177 | c.528C>T | synonymous_variant | 0.18 | pyrazinamide | |
clpC1 | 4040517 | p.Val63Ala | missense_variant | 0.32 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4040654 | c.51G>A | synonymous_variant | 0.21 | pyrazinamide | |
clpC1 | 4040657 | c.48T>G | synonymous_variant | 0.21 | pyrazinamide | Not assoc w R - Interim |
panD | 4044162 | c.120A>G | synonymous_variant | 0.15 | pyrazinamide | |
panD | 4044165 | c.117G>C | synonymous_variant | 0.15 | pyrazinamide | |
panD | 4044188 | c.94T>C | synonymous_variant | 0.19 | pyrazinamide | |
panD | 4044195 | c.87T>C | synonymous_variant | 0.2 | pyrazinamide | |
panD | 4044210 | c.72C>A | synonymous_variant | 0.14 | pyrazinamide | |
panD | 4044266 | c.16C>T | synonymous_variant | 0.14 | pyrazinamide | |
panD | 4044755 | c.-474G>A | upstream_gene_variant | 0.31 | pyrazinamide | |
glpK | 4138377 | p.Val460Ala | missense_variant | 0.45 | levofloxacin | Not assoc w R |
moxifloxacin | Not assoc w R | |||||
isoniazid | Not assoc w R | |||||
streptomycin | Not assoc w R | |||||
rifampicin | Not assoc w R | |||||
ethambutol | Not assoc w R | |||||
glpK | 4138696 | p.Pro354Ala | missense_variant | 0.15 | levofloxacin | |
moxifloxacin | ||||||
isoniazid | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
glpK | 4139165 | c.591A>G | synonymous_variant | 0.13 | levofloxacin | |
moxifloxacin | ||||||
isoniazid | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
glpK | 4139168 | c.588T>C | synonymous_variant | 0.13 | levofloxacin | |
moxifloxacin | ||||||
isoniazid | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
glpK | 4139987 | c.-232G>A | upstream_gene_variant | 0.41 | levofloxacin | |
moxifloxacin | ||||||
isoniazid | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
embC | 4238963 | c.-900C>T | upstream_gene_variant | 0.49 | ethambutol | Not assoc w R |
embC | 4239723 | c.-140C>G | upstream_gene_variant | 0.2 | ethambutol | |
embC | 4240671 | p.Thr270Ile | missense_variant | 0.32 | ethambutol | Not assoc w R |
embC | 4240693 | c.831T>G | synonymous_variant | 0.13 | ethambutol | |
embC | 4240717 | c.855T>C | synonymous_variant | 0.16 | ethambutol | |
embC | 4240726 | c.864G>C | synonymous_variant | 0.13 | ethambutol | Not assoc w R - Interim |
embC | 4240750 | c.888C>T | synonymous_variant | 0.39 | ethambutol | Not assoc w R |
embC | 4241042 | p.Asn394Asp | missense_variant | 0.42 | ethambutol | Not assoc w R |
embC | 4241380 | c.1518A>C | synonymous_variant | 0.15 | ethambutol | |
embC | 4241383 | c.1521G>C | synonymous_variant | 0.15 | ethambutol | Not assoc w R - Interim |
embC | 4242133 | c.2271G>C | synonymous_variant | 0.14 | ethambutol | |
embC | 4242136 | c.2274G>A | synonymous_variant | 0.14 | ethambutol | |
embC | 4242643 | c.2781C>T | synonymous_variant | 1.0 | ethambutol | Not assoc w R |
embA | 4244666 | c.1434G>C | synonymous_variant | 0.2 | ethambutol | |
embA | 4244668 | p.Val479Ala | missense_variant | 0.19 | ethambutol | |
embA | 4244675 | c.1443A>G | synonymous_variant | 0.19 | ethambutol | |
embA | 4244681 | c.1449A>G | synonymous_variant | 0.15 | ethambutol | Not assoc w R - Interim |
embA | 4244684 | c.1452C>T | synonymous_variant | 0.15 | ethambutol | |
embA | 4244695 | p.Lys488Thr | missense_variant | 0.29 | ethambutol | |
embA | 4244702 | c.1470C>G | synonymous_variant | 0.28 | ethambutol | |
embA | 4244708 | c.1476C>A | synonymous_variant | 0.2 | ethambutol | |
embA | 4245321 | p.Met697Val | missense_variant | 0.4 | ethambutol | Uncertain significance |
embA | 4245969 | p.Pro913Ser | missense_variant | 0.33 | ethambutol | Not assoc w R |
embB | 4247611 | c.1098G>C | synonymous_variant | 0.16 | ethambutol | |
embB | 4247614 | c.1101T>C | synonymous_variant | 0.16 | ethambutol | Not assoc w R - Interim |
embB | 4247646 | p.Glu378Ala | missense_variant | 0.51 | ethambutol | Not assoc w R |
embB | 4248784 | c.2271T>G | synonymous_variant | 0.17 | ethambutol | |
embB | 4248787 | c.2274T>C | synonymous_variant | 0.17 | ethambutol | |
embB | 4249381 | c.2868A>G | synonymous_variant | 0.15 | ethambutol | |
embB | 4249447 | c.2934G>C | synonymous_variant | 0.19 | ethambutol | |
aftB | 4267517 | c.1320A>G | synonymous_variant | 0.31 | ethambutol | Not assoc w R - Interim |
aftB | 4268429 | c.408C>G | synonymous_variant | 0.15 | ethambutol | |
aftB | 4268432 | c.405C>G | synonymous_variant | 0.15 | ethambutol | |
aftB | 4269186 | c.-350C>G | upstream_gene_variant | 0.16 | ethambutol | |
aftB | 4269201 | c.-365A>G | upstream_gene_variant | 0.16 | ethambutol | |
ubiA | 4269387 | p.Glu149Asp | missense_variant | 0.35 | ethambutol | Not assoc w R |
ubiA | 4269606 | c.228T>C | synonymous_variant | 0.36 | ethambutol | Not assoc w R |
ethA | 4326439 | p.Asn345Lys | missense_variant | 0.48 | ethionamide | Uncertain significance |
ethA | 4327450 | c.24C>T | synonymous_variant | 0.4 | ethionamide | Not assoc w R - Interim |
whiB6 | 4338545 | c.-24G>A | upstream_gene_variant | 0.41 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
whiB6 | 4338595 | c.-75delG | upstream_gene_variant | 1.0 | kanamycin | Not assoc w R |
capreomycin | Not assoc w R | |||||
amikacin | Not assoc w R | |||||
whiB6 | 4338600 | c.-79T>C | upstream_gene_variant | 0.29 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
whiB6 | 4338603 | c.-82C>T | upstream_gene_variant | 0.29 | kanamycin | Not assoc w R |
capreomycin | Not assoc w R | |||||
amikacin | Not assoc w R | |||||
whiB6 | 4338621 | c.-100G>T | upstream_gene_variant | 0.31 | kanamycin | |
capreomycin | ||||||
amikacin | ||||||
whiB6 | 4338732 | c.-211C>T | upstream_gene_variant | 1.0 | kanamycin | |
capreomycin | ||||||
amikacin | ||||||
gid | 4407588 | c.615A>G | synonymous_variant | 0.19 | streptomycin | Not assoc w R |
gid | 4407873 | c.330G>T | synonymous_variant | 0.42 | streptomycin | Not assoc w R |
gid | 4408082 | p.Val41Leu | missense_variant | 0.31 | streptomycin | Uncertain significance |