TB-Profiler result

Run: SRR28044873
Summary

Run ID: SRR28044873

Sample name:

Date: 2024-05-22T19:43:56.933479

Number of reads: 5642240

Percentage reads mapped: 93.19

Median coverage: 152.0

Strain: lineage3

Spoligotype:

Drug-resistance: Pre-XDR-TB

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage3 East-African-Indian RD750 0.99
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin rpoB p.Asp435Val Assoc w R
isoniazid
ethambutol
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin gyrA p.Asp94Gly Assoc w R High-level resistance
ofloxacin
levofloxacin gyrA p.Asp94Gly Assoc w R
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
gyrA 7582 p.Asp94Gly missense_variant 0.74 moxifloxacin Assoc w R High-level resistance
levofloxacin Assoc w R
rpoB 761110 p.Asp435Val missense_variant 0.99 rifampicin Assoc w R
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
dnaA 633 c.633T>C synonymous_variant 0.15 isoniazid
dnaA 645 c.645A>C synonymous_variant 0.15 isoniazid Not assoc w R - Interim
dnaA 648 c.648C>T synonymous_variant 0.15 isoniazid
dnaA 654 c.654A>G synonymous_variant 0.16 isoniazid
dnaA 660 c.660G>C synonymous_variant 0.15 isoniazid Not assoc w R - Interim
dnaA 663 c.663A>G synonymous_variant 0.15 isoniazid Not assoc w R - Interim
dnaA 672 c.672T>C synonymous_variant 0.16 isoniazid Not assoc w R - Interim
dnaA 678 c.678A>G synonymous_variant 0.15 isoniazid Not assoc w R - Interim
dnaA 681 c.681G>C synonymous_variant 0.15 isoniazid
dnaA 693 c.693A>C synonymous_variant 0.17 isoniazid
dnaA 702 c.702C>G synonymous_variant 0.16 isoniazid
dnaA 705 c.705A>G synonymous_variant 0.16 isoniazid
dnaA 708 c.708T>C synonymous_variant 0.16 isoniazid
dnaA 714 c.714C>G synonymous_variant 0.18 isoniazid Not assoc w R - Interim
dnaA 741 c.741T>C synonymous_variant 0.2 isoniazid Not assoc w R - Interim
dnaA 750 c.750C>G synonymous_variant 0.17 isoniazid
dnaA 753 c.753C>T synonymous_variant 0.17 isoniazid
dnaA 756 c.756T>C synonymous_variant 0.17 isoniazid
dnaA 786 c.786C>T synonymous_variant 0.16 isoniazid
dnaA 793 c.793_795delGTAinsAC frameshift_variant&missense_variant 0.15 isoniazid Uncertain significance
dnaA 801 c.801G>C synonymous_variant 0.18 isoniazid
dnaA 805 c.805T>C synonymous_variant 0.18 isoniazid
dnaA 822 c.822A>G synonymous_variant 0.21 isoniazid
dnaA 828 c.828T>C synonymous_variant 0.21 isoniazid Not assoc w R - Interim
dnaA 831 c.831A>G synonymous_variant 0.2 isoniazid
dnaA 837 c.837A>G synonymous_variant 0.2 isoniazid
dnaA 840 c.840G>A synonymous_variant 0.2 isoniazid
dnaA 843 c.843T>C synonymous_variant 0.21 isoniazid Not assoc w R - Interim
dnaA 846 c.846T>C synonymous_variant 0.2 isoniazid
dnaA 849 c.849A>G synonymous_variant 0.21 isoniazid
dnaA 876 c.876C>A synonymous_variant 0.18 isoniazid
dnaA 877 c.877T>C synonymous_variant 0.18 isoniazid
dnaA 885 c.885T>C synonymous_variant 0.18 isoniazid
dnaA 888 c.888C>G synonymous_variant 0.17 isoniazid
dnaA 897 c.897A>G synonymous_variant 0.18 isoniazid
dnaA 909 c.909A>C synonymous_variant 0.2 isoniazid Not assoc w R - Interim
dnaA 912 c.912T>C synonymous_variant 0.2 isoniazid
dnaA 918 c.918C>G synonymous_variant 0.19 isoniazid
dnaA 921 c.921A>G synonymous_variant 0.18 isoniazid Not assoc w R - Interim
dnaA 927 c.927G>A synonymous_variant 0.17 isoniazid
dnaA 933 c.933C>G synonymous_variant 0.16 isoniazid
dnaA 942 c.942C>G synonymous_variant 0.14 isoniazid
gyrB 6172 c.933C>T synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrB 6181 c.942C>T synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrB 6196 c.957C>G synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrB 6203 p.Ser322Ala missense_variant 0.2 levofloxacin
moxifloxacin
gyrB 6217 c.978G>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrB 6242 p.Arg335Lys missense_variant 0.29 levofloxacin
moxifloxacin
gyrB 6250 c.1011A>G synonymous_variant 0.29 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6253 c.1014G>C synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrB 6286 c.1047T>C synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrB 6292 c.1053G>C synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrB 6298 c.1059C>T synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6301 c.1062G>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 6304 c.-998C>G upstream_gene_variant 0.21 levofloxacin
moxifloxacin
gyrB 6307 c.1068T>G synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6547 c.-755T>C upstream_gene_variant 0.15 levofloxacin
moxifloxacin
gyrA 6550 c.-752A>T upstream_gene_variant 0.15 levofloxacin
moxifloxacin
gyrB 6551 c.1312T>C synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6565 c.-737G>C upstream_gene_variant 0.16 levofloxacin
moxifloxacin
gyrA 6571 c.-731T>C upstream_gene_variant 0.15 levofloxacin
moxifloxacin
gyrA 6589 c.-713G>C upstream_gene_variant 0.16 levofloxacin
moxifloxacin
gyrA 6598 c.-704C>G upstream_gene_variant 0.18 levofloxacin
moxifloxacin
gyrA 6610 c.-692C>G upstream_gene_variant 0.17 levofloxacin
moxifloxacin
gyrA 6613 c.-689A>G upstream_gene_variant 0.16 levofloxacin
moxifloxacin
gyrA 6616 c.-686A>G upstream_gene_variant 0.16 levofloxacin
moxifloxacin
gyrA 6619 c.-683T>C upstream_gene_variant 0.16 levofloxacin
moxifloxacin
gyrA 6622 c.-680C>T upstream_gene_variant 0.17 levofloxacin
moxifloxacin
gyrA 6634 c.-668T>C upstream_gene_variant 0.2 levofloxacin
moxifloxacin
gyrA 6637 c.-665T>G upstream_gene_variant 0.2 levofloxacin
moxifloxacin
gyrA 6640 c.-662A>C upstream_gene_variant 0.21 levofloxacin
moxifloxacin
gyrA 6643 c.-659A>G upstream_gene_variant 0.21 levofloxacin
moxifloxacin
gyrA 6649 c.-653T>C upstream_gene_variant 0.21 levofloxacin
moxifloxacin
gyrA 6673 c.-629A>C upstream_gene_variant 0.2 levofloxacin
moxifloxacin
gyrA 6676 c.-626T>G upstream_gene_variant 0.19 levofloxacin
moxifloxacin
gyrA 6700 c.-602T>C upstream_gene_variant 0.18 levofloxacin
moxifloxacin
gyrA 6703 c.-599G>C upstream_gene_variant 0.18 levofloxacin
moxifloxacin
gyrA 6709 c.-593A>G upstream_gene_variant 0.17 levofloxacin
moxifloxacin
gyrA 6730 c.-572A>G upstream_gene_variant 0.17 levofloxacin
moxifloxacin
gyrA 6760 c.-542G>C upstream_gene_variant 0.15 levofloxacin
moxifloxacin
gyrA 6766 c.-536G>C upstream_gene_variant 0.14 levofloxacin
moxifloxacin
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7565 c.264C>T synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7585 p.Ser95Thr missense_variant 0.99 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7595 c.294C>G synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrA 7607 c.306C>G synonymous_variant 0.32 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7613 c.312G>A synonymous_variant 0.32 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7631 c.330G>C synonymous_variant 0.35 levofloxacin
moxifloxacin
gyrA 7652 c.351C>T synonymous_variant 0.36 levofloxacin
moxifloxacin
gyrA 7658 c.357A>G synonymous_variant 0.36 levofloxacin
moxifloxacin
gyrA 7664 c.363T>C synonymous_variant 0.35 levofloxacin
moxifloxacin
gyrA 7667 c.366C>T synonymous_variant 0.34 levofloxacin
moxifloxacin
gyrA 7670 c.369A>G synonymous_variant 0.34 levofloxacin
moxifloxacin
gyrA 7676 c.375G>C synonymous_variant 0.34 levofloxacin
moxifloxacin
gyrA 7683 c.382A>C synonymous_variant 0.34 levofloxacin
moxifloxacin
gyrA 7697 c.396C>G synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrA 7706 c.405C>T synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrA 7709 c.408G>C synonymous_variant 0.32 levofloxacin
moxifloxacin
gyrA 7710 c.409T>C synonymous_variant 0.32 levofloxacin
moxifloxacin
gyrA 7728 c.427_429delAGGinsCC frameshift_variant&missense_variant 0.33 levofloxacin
moxifloxacin
gyrA 7760 c.459C>A synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrA 7763 c.462T>G synonymous_variant 0.32 levofloxacin
moxifloxacin
gyrA 7769 c.468C>T synonymous_variant 0.31 levofloxacin
moxifloxacin
gyrA 7784 c.483A>G synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 7793 c.492G>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 7796 c.495G>T synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 7799 c.498A>G synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7802 c.501C>G synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 7817 c.516C>T synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 7829 c.528C>T synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7832 c.531G>T synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 7835 c.534A>G synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7853 c.552C>T synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7859 c.558A>G synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
fgd1 491742 c.960T>C synonymous_variant 1.0 clofazimine Not assoc w R
pretomanid
delamanid Not assoc w R - Interim
mshA 575842 c.495G>C synonymous_variant 0.15 ethionamide
isoniazid
mshA 575864 c.517T>C synonymous_variant 0.18 ethionamide
isoniazid
mshA 575878 c.531A>C synonymous_variant 0.17 ethionamide
isoniazid
mshA 575893 c.546C>G synonymous_variant 0.17 ethionamide
isoniazid
mshA 575905 c.558G>C synonymous_variant 0.17 ethionamide
isoniazid
mshA 575908 c.561A>C synonymous_variant 0.17 ethionamide
isoniazid Not assoc w R - Interim
mshA 575920 c.573C>T synonymous_variant 0.16 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
mshA 575925 p.Gly193Ala missense_variant 0.16 ethionamide
isoniazid
ccsA 620373 c.483C>G synonymous_variant 0.14 capreomycin
amikacin
kanamycin
ccsA 620385 c.495G>C synonymous_variant 0.14 capreomycin
amikacin
kanamycin
ccsA 620388 c.498A>G synonymous_variant 0.15 capreomycin
amikacin
kanamycin
ccsA 620397 c.507C>G synonymous_variant 0.14 capreomycin
amikacin
kanamycin
ccsA 620412 c.522T>C synonymous_variant 0.15 capreomycin
amikacin
kanamycin
ccsA 620415 c.525T>C synonymous_variant 0.14 capreomycin Not assoc w R - Interim
amikacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
Rv0565c 657081 c.390G>A synonymous_variant 1.0 ethionamide Not assoc w R - Interim
nusG 734439 c.186C>G synonymous_variant 0.21 rifampicin
nusG 734442 c.189G>A synonymous_variant 0.21 rifampicin
nusG 734451 c.198G>C synonymous_variant 0.21 rifampicin
nusG 734454 c.201A>G synonymous_variant 0.22 rifampicin
nusG 734460 c.207G>C synonymous_variant 0.22 rifampicin
nusG 734472 c.219T>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
nusG 734478 c.225C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
nusG 734481 c.228C>T synonymous_variant 0.2 rifampicin
nusG 734499 c.246G>C synonymous_variant 0.21 rifampicin
nusG 734532 c.279A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
nusG 734541 c.288A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 759746 c.-61C>T upstream_gene_variant 1.0 rifampicin Not assoc w R
rpoB 760511 c.705G>C synonymous_variant 0.14 rifampicin
rpoB 761645 c.1839C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761648 c.1842T>C synonymous_variant 0.16 rifampicin
rpoB 761666 c.1860G>C synonymous_variant 0.23 rifampicin
rpoB 761675 c.1869G>C synonymous_variant 0.27 rifampicin
rpoB 761690 c.1884G>C synonymous_variant 0.26 rifampicin
rpoB 761718 p.Ala638Ser missense_variant 0.25 rifampicin
rpoB 761735 c.1929C>G synonymous_variant 0.26 rifampicin
rpoB 761736 p.Ile644Val missense_variant 0.26 rifampicin Uncertain significance
rpoB 761747 c.1941G>C synonymous_variant 0.27 rifampicin
rpoB 761765 c.1959T>C synonymous_variant 0.25 rifampicin
rpoB 761772 p.His656Ala missense_variant 0.25 rifampicin
rpoB 761778 p.Asn658Asp missense_variant 0.24 rifampicin
rpoB 761791 p.Arg662His missense_variant 0.18 rifampicin
rpoB 762434 c.2628T>G synonymous_variant 0.99 rifampicin Not assoc w R
rpoB 763031 c.3225T>C synonymous_variant 1.0 rifampicin Not assoc w R
rpoC 765452 p.Ala695Arg missense_variant 0.15 rifampicin
rpoC 765466 c.2097C>T synonymous_variant 0.22 rifampicin
rpoC 765478 c.2109T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 765480 p.Tyr704Phe missense_variant 0.23 rifampicin Uncertain significance
rpoC 765496 c.2127C>G synonymous_variant 0.23 rifampicin
rpoC 765499 c.2130C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 766345 c.2976T>C synonymous_variant 0.16 rifampicin
rpoC 766348 c.2979A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 766357 c.2988C>T synonymous_variant 0.18 rifampicin
rpoC 766363 c.2994G>C synonymous_variant 0.21 rifampicin
rpoC 766369 c.3000C>G synonymous_variant 0.21 rifampicin
rpoC 766384 c.3015A>G synonymous_variant 0.23 rifampicin
rpoC 766390 c.3021C>T synonymous_variant 0.25 rifampicin
rpoC 766393 c.3024C>G synonymous_variant 0.27 rifampicin
rpoC 766423 c.3054T>C synonymous_variant 0.35 rifampicin
rpoC 766426 c.3057C>T synonymous_variant 0.34 rifampicin
rpoC 766429 c.3060C>G synonymous_variant 0.34 rifampicin
rpoC 766459 c.3090G>C synonymous_variant 0.37 rifampicin
rpoC 766469 c.3100C>T synonymous_variant 0.36 rifampicin
rpoC 766483 c.3114G>C synonymous_variant 0.33 rifampicin
rpoC 766486 c.3117A>G synonymous_variant 0.33 rifampicin
rpoC 766492 c.3123T>C synonymous_variant 0.32 rifampicin
rpoC 766493 p.Gly1042Asn missense_variant 0.31 rifampicin
rpoC 766525 c.3156G>C synonymous_variant 0.29 rifampicin
rpoC 766528 c.3159T>G synonymous_variant 0.28 rifampicin
rpoC 766534 c.3165C>G synonymous_variant 0.28 rifampicin
rpoC 766540 p.Asp1057Glu missense_variant 0.27 rifampicin
rpoC 766546 p.Glu1059Asp missense_variant 0.23 rifampicin
rpoC 766549 c.3180G>C synonymous_variant 0.22 rifampicin
rpoC 766570 c.3201T>C synonymous_variant 0.16 rifampicin
rpoC 766573 c.3204T>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 766585 c.3216T>C synonymous_variant 0.15 rifampicin
rpoC 766726 c.3357T>C synonymous_variant 0.16 rifampicin
rpoC 766738 c.3369G>T synonymous_variant 0.16 rifampicin
rpoC 766750 c.3381C>G synonymous_variant 0.14 rifampicin
rpoC 766765 c.3396A>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 766774 c.3405T>C synonymous_variant 0.16 rifampicin
rpoC 766776 p.Arg1136His missense_variant 0.17 rifampicin
rpoC 766798 c.3429C>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 766804 c.3435A>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 766807 c.3438T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 766837 c.3468G>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 766843 c.3474T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 766846 c.3477C>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 766861 c.3492G>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 766864 c.3495G>C synonymous_variant 0.32 rifampicin
rpoC 766867 c.3498C>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 766883 c.3514_3516delTCGinsGC frameshift_variant&missense_variant 0.32 rifampicin
rpoC 766894 c.3525T>C synonymous_variant 0.33 rifampicin
rpoC 766895 c.3526T>C synonymous_variant 0.34 rifampicin
rpoC 766900 c.3531T>C synonymous_variant 0.34 rifampicin
rpoC 766911 p.Ile1181Thr missense_variant 0.34 rifampicin
rpoC 766915 p.Asp1182Glu missense_variant 0.34 rifampicin
rpoC 766918 c.3549C>T synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 766931 c.3562_3564delGCAinsTG frameshift_variant&stop_gained 0.32 rifampicin
rpoC 766942 c.3573C>T synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 766945 c.3576A>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 766962 p.Gly1198Ala missense_variant 0.31 rifampicin
rpoC 766975 c.3606C>G synonymous_variant 0.24 rifampicin
rpoC 766996 c.3627C>T synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 767002 c.3633G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 767020 c.3651C>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 767023 c.3654C>T synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 767059 c.3690T>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 767062 c.3693C>A synonymous_variant 0.26 rifampicin
rpoC 767098 c.3729T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 767104 c.3735C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 767105 c.3736_3738delAACinsCG frameshift_variant&missense_variant 0.21 rifampicin
rpoC 767119 c.3750A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 767158 c.3789T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
mmpL5 775639 p.Ile948Val missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
mmpL5 775916 c.2565T>G synonymous_variant 0.15 clofazimine
bedaquiline
mmpL5 775946 c.2535C>G synonymous_variant 0.19 clofazimine
bedaquiline
mmpL5 775951 c.2530C>T synonymous_variant 0.19 clofazimine
bedaquiline
mmpL5 775966 p.Ala839Ser missense_variant 0.19 clofazimine
bedaquiline
mmpL5 775975 p.Leu836Met missense_variant 0.23 clofazimine
bedaquiline
mmpL5 775981 p.Leu834Met missense_variant 0.23 clofazimine
bedaquiline
mmpL5 775991 c.2490G>A synonymous_variant 0.23 clofazimine
bedaquiline
mmpL5 775997 c.2484T>C synonymous_variant 0.24 clofazimine
bedaquiline
mmpL5 776003 c.2476_2478delATCinsCG frameshift_variant&missense_variant 0.19 clofazimine Uncertain significance
bedaquiline Uncertain significance
mmpL5 776009 c.2472A>G synonymous_variant 0.22 clofazimine
bedaquiline
mmpL5 776021 c.2460G>C synonymous_variant 0.16 clofazimine
bedaquiline
mmpL5 776100 p.Thr794Ile missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rplC 800537 c.-272C>G upstream_gene_variant 0.14 linezolid
rplC 800540 c.-269T>C upstream_gene_variant 0.15 linezolid
rplC 800546 c.-263T>C upstream_gene_variant 0.16 linezolid
rplC 800564 c.-245C>G upstream_gene_variant 0.17 linezolid
rplC 800567 c.-242A>G upstream_gene_variant 0.17 linezolid
rplC 800570 c.-239C>G upstream_gene_variant 0.17 linezolid
rplC 800574 c.-235_-234delGTinsAC upstream_gene_variant 0.17 linezolid
rplC 800579 c.-230C>T upstream_gene_variant 0.18 linezolid
rplC 800594 c.-215C>G upstream_gene_variant 0.19 linezolid
rplC 800597 c.-212A>G upstream_gene_variant 0.19 linezolid
rplC 800600 c.-209G>C upstream_gene_variant 0.19 linezolid
rplC 800603 c.-206G>T upstream_gene_variant 0.2 linezolid
rplC 800612 c.-197A>G upstream_gene_variant 0.22 linezolid
rplC 800618 c.-191T>C upstream_gene_variant 0.2 linezolid
rplC 800633 c.-176T>C upstream_gene_variant 0.2 linezolid
rplC 800645 c.-164C>G upstream_gene_variant 0.19 linezolid
rplC 800648 c.-161A>C upstream_gene_variant 0.19 linezolid
rplC 800654 c.-155T>C upstream_gene_variant 0.17 linezolid
rplC 800715 c.-94A>C upstream_gene_variant 0.15 linezolid
rplC 800720 c.-89T>C upstream_gene_variant 0.15 linezolid
rplC 800762 c.-47T>G upstream_gene_variant 0.14 linezolid
rplC 800768 c.-41C>G upstream_gene_variant 0.15 linezolid
rplC 800807 c.-2C>A upstream_gene_variant 0.17 linezolid
rplC 800817 c.9A>T synonymous_variant 0.2 linezolid
rplC 800820 c.12G>A synonymous_variant 0.21 linezolid
rplC 800829 c.21C>G synonymous_variant 0.21 linezolid
rplC 800832 c.24T>C synonymous_variant 0.21 linezolid
rplC 800835 c.27C>G synonymous_variant 0.22 linezolid
rplC 800865 c.57A>G synonymous_variant 0.21 linezolid
rplC 800867 p.Ser20Asn missense_variant 0.21 linezolid
rplC 800872 c.64_66delAGAinsCC frameshift_variant&missense_variant 0.2 linezolid
rplC 800877 c.69A>C synonymous_variant 0.21 linezolid
rplC 800880 c.72A>G synonymous_variant 0.21 linezolid
rplC 800889 c.81C>G synonymous_variant 0.22 linezolid
rplC 800892 c.84G>C synonymous_variant 0.22 linezolid
rplC 800904 c.96G>A synonymous_variant 0.22 linezolid
rplC 800910 c.102C>T synonymous_variant 0.2 linezolid
rplC 800913 c.105G>C synonymous_variant 0.2 linezolid
rplC 800916 c.108A>G synonymous_variant 0.2 linezolid
rplC 800931 c.123G>C synonymous_variant 0.15 linezolid
Rv1129c 1254562 c.-28T>C upstream_gene_variant 0.99 moxifloxacin Not assoc w R
levofloxacin Not assoc w R
rifampicin Not assoc w R
isoniazid Not assoc w R
atpE 1461149 c.105T>G synonymous_variant 0.15 bedaquiline
atpE 1461153 c.109_111delTCCinsGG frameshift_variant&missense_variant 0.15 bedaquiline
atpE 1461158 c.114T>C synonymous_variant 0.15 bedaquiline
atpE 1461159 p.Val39Ile missense_variant 0.15 bedaquiline Uncertain significance
atpE 1461167 c.123G>C synonymous_variant 0.15 bedaquiline
atpE 1461170 c.126A>G synonymous_variant 0.15 bedaquiline
atpE 1461173 c.129C>G synonymous_variant 0.15 bedaquiline
atpE 1461179 c.135G>C synonymous_variant 0.15 bedaquiline
atpE 1461182 c.138A>G synonymous_variant 0.15 bedaquiline
atpE 1461185 c.141G>T synonymous_variant 0.15 bedaquiline
atpE 1461188 c.144G>C synonymous_variant 0.15 bedaquiline
atpE 1461197 c.153A>G synonymous_variant 0.15 bedaquiline
atpE 1461212 c.168C>G synonymous_variant 0.15 bedaquiline
atpE 1461219 c.175T>C synonymous_variant 0.15 bedaquiline
atpE 1461224 c.180T>C synonymous_variant 0.15 bedaquiline
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrl 1474626 n.969T>C non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474629 n.972G>A non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid
rrl 1474632 n.975G>T non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474636 n.979A>T non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid
rrl 1474637 n.980C>T non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid
rrl 1474638 n.981C>G non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474639 n.982G>T non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid
rrl 1474640 n.983C>T non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid
rrl 1474708 n.1052_1053insACAAG non_coding_transcript_exon_variant 0.38 capreomycin
linezolid
rrl 1474711 n.1055_1058delGTGT non_coding_transcript_exon_variant 0.38 capreomycin
linezolid
rrl 1474717 n.1060A>G non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid
rrl 1474720 n.1063C>T non_coding_transcript_exon_variant 0.35 capreomycin
linezolid
rrl 1474753 n.1096A>G non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid
rrl 1474760 n.1103A>G non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474830 n.1173A>G non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475419 n.1762C>T non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid
rrl 1475429 n.1772G>A non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475452 n.1795C>A non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475479 n.1822C>T non_coding_transcript_exon_variant 0.45 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475480 n.1823A>G non_coding_transcript_exon_variant 0.45 capreomycin
linezolid
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475532 n.1875A>G non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475544 n.1887A>T non_coding_transcript_exon_variant 0.54 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475545 n.1888T>G non_coding_transcript_exon_variant 0.54 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475602 n.1945G>C non_coding_transcript_exon_variant 0.45 capreomycin Uncertain significance
linezolid
rrl 1475603 n.1946G>C non_coding_transcript_exon_variant 0.44 capreomycin
linezolid
rrl 1475604 n.1947A>C non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid
rrl 1475629 n.1972G>T non_coding_transcript_exon_variant 0.41 capreomycin
linezolid
rrl 1475637 n.1980T>G non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid
rrl 1475638 n.1981C>G non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid
rrl 1475639 n.1982C>G non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid
rrl 1475643 n.1986C>G non_coding_transcript_exon_variant 0.41 capreomycin
linezolid
rrl 1475647 n.1990G>C non_coding_transcript_exon_variant 0.41 capreomycin
linezolid
rrl 1475659 n.2002G>A non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475707 n.2050T>G non_coding_transcript_exon_variant 0.41 capreomycin
linezolid
rrl 1475753 n.2096C>G non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid
rrl 1475762 n.2105G>T non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid
rrl 1475763 n.2106C>T non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid
rrl 1475764 n.2107A>C non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid
rrl 1475765 n.2108A>G non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid
rrl 1475775 n.2118G>T non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475916 n.2259C>T non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.23 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1475989 n.2332T>A non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1475995 n.2338G>A non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid
inhA 1674576 c.375T>C synonymous_variant 0.16 ethionamide
isoniazid
inhA 1674579 c.378G>C synonymous_variant 0.16 ethionamide
isoniazid
inhA 1674582 c.381T>C synonymous_variant 0.16 ethionamide
isoniazid
inhA 1674585 c.384T>C synonymous_variant 0.17 ethionamide
isoniazid
inhA 1674589 p.Met130Leu missense_variant 0.16 ethionamide
isoniazid
inhA 1674600 c.399G>C synonymous_variant 0.17 ethionamide
isoniazid
inhA 1674601 p.Leu134Val missense_variant 0.17 ethionamide
isoniazid
inhA 1674618 c.417C>T synonymous_variant 0.15 ethionamide
isoniazid
inhA 1674621 c.420C>G synonymous_variant 0.16 ethionamide
isoniazid
inhA 1674624 c.423A>C synonymous_variant 0.15 ethionamide
isoniazid
inhA 1674627 c.426T>C synonymous_variant 0.16 ethionamide
isoniazid
inhA 1674628 p.Ser143Gly missense_variant 0.16 ethionamide
isoniazid
inhA 1674639 c.438C>T synonymous_variant 0.18 ethionamide
isoniazid
inhA 1674654 c.453G>C synonymous_variant 0.19 ethionamide
isoniazid
inhA 1674718 c.517A>C synonymous_variant 0.16 ethionamide
isoniazid
inhA 1674726 c.525G>C synonymous_variant 0.16 ethionamide
isoniazid
inhA 1674729 c.528G>T synonymous_variant 0.16 ethionamide
isoniazid
inhA 1674738 c.537C>G synonymous_variant 0.18 ethionamide
isoniazid
inhA 1674745 p.Tyr182Val missense_variant 0.18 ethionamide
isoniazid
inhA 1674750 c.549T>C synonymous_variant 0.18 ethionamide
isoniazid
inhA 1674759 c.558G>C synonymous_variant 0.22 ethionamide
isoniazid
inhA 1674771 c.570C>G synonymous_variant 0.23 ethionamide
isoniazid
inhA 1674774 c.573A>G synonymous_variant 0.24 ethionamide
isoniazid
inhA 1674780 c.579T>G synonymous_variant 0.25 ethionamide
isoniazid
inhA 1674789 c.588G>A synonymous_variant 0.25 ethionamide
isoniazid
inhA 1674801 c.600T>C synonymous_variant 0.26 ethionamide
isoniazid
inhA 1674816 c.615T>C synonymous_variant 0.27 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
inhA 1674819 c.618G>C synonymous_variant 0.27 ethionamide
isoniazid
inhA 1674828 p.Glu209Asp missense_variant 0.28 ethionamide
isoniazid
inhA 1674846 p.Ile215Met missense_variant 0.28 ethionamide
isoniazid
inhA 1674870 c.669T>C synonymous_variant 0.25 ethionamide
isoniazid
inhA 1674876 c.675C>G synonymous_variant 0.24 ethionamide
isoniazid
inhA 1674879 c.678T>C synonymous_variant 0.22 ethionamide
isoniazid
inhA 1674883 p.Ile228Leu missense_variant 0.22 ethionamide
isoniazid
inhA 1674903 c.702T>C synonymous_variant 0.17 ethionamide
isoniazid
inhA 1674904 p.Ala235Pro missense_variant 0.17 ethionamide
isoniazid
inhA 1674909 c.708G>C synonymous_variant 0.16 ethionamide
isoniazid
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
katG 2154724 p.Arg463Leu missense_variant 1.0 isoniazid Not assoc w R
katG 2155688 p.Asp142Asn missense_variant 0.99 isoniazid Uncertain significance
PPE35 2167926 p.Leu896Ser missense_variant 1.0 pyrazinamide Not assoc w R
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
pncA 2289047 c.195C>T synonymous_variant 1.0 pyrazinamide Not assoc w R
pncA 2289365 c.-125delC upstream_gene_variant 1.0 pyrazinamide
ahpC 2726105 c.-88G>A upstream_gene_variant 0.99 isoniazid Not assoc w R
ahpC 2726113 c.-79_-73delCCTTTGC upstream_gene_variant 0.99 isoniazid
ahpC 2726124 c.-69A>G upstream_gene_variant 0.99 isoniazid
Rv2477c 2782498 c.1545C>T synonymous_variant 1.0 ethambutol Not assoc w R
moxifloxacin Not assoc w R
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R
kanamycin Not assoc w R
rifampicin Not assoc w R
amikacin Not assoc w R
Rv2752c 3066946 c.-755C>G upstream_gene_variant 1.0 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
thyA 3073902 c.570C>G synonymous_variant 0.14 para-aminosalicylic_acid
thyA 3073920 c.552C>G synonymous_variant 0.2 para-aminosalicylic_acid
thyA 3073953 c.519T>G synonymous_variant 0.28 para-aminosalicylic_acid
thyA 3073958 c.514C>T synonymous_variant 0.26 para-aminosalicylic_acid
thyA 3073968 c.504C>G synonymous_variant 0.27 para-aminosalicylic_acid
thyA 3073977 c.495A>G synonymous_variant 0.28 para-aminosalicylic_acid
thyA 3073980 c.492C>T synonymous_variant 0.27 para-aminosalicylic_acid
thyA 3073989 c.483T>C synonymous_variant 0.25 para-aminosalicylic_acid
thyA 3074004 c.468T>C synonymous_variant 0.18 para-aminosalicylic_acid
thyA 3074031 c.441T>C synonymous_variant 0.17 para-aminosalicylic_acid
thyA 3074034 c.438T>C synonymous_variant 0.17 para-aminosalicylic_acid
thyA 3074037 c.435C>G synonymous_variant 0.17 para-aminosalicylic_acid
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
mtrB 3625065 p.Met517Leu missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
alr 3841473 c.-53G>A upstream_gene_variant 1.0 cycloserine
rpoA 3877818 c.690A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoA 3877836 c.672A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3877842 c.666A>C synonymous_variant 0.21 rifampicin
rpoA 3877848 c.660C>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoA 3877856 c.652T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoA 3877875 c.633T>G synonymous_variant 0.27 rifampicin
rpoA 3877881 c.627G>C synonymous_variant 0.27 rifampicin
rpoA 3877884 c.624G>C synonymous_variant 0.28 rifampicin
rpoA 3877893 c.615C>T synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoA 3877900 p.Ser203Thr missense_variant 0.28 rifampicin
rpoA 3877905 c.603A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoA 3877908 c.600T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoA 3877920 c.588G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoA 3877923 c.585C>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoA 3877926 c.582G>C synonymous_variant 0.24 rifampicin
rpoA 3877962 c.546G>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3877971 p.Asp179Glu missense_variant 0.16 rifampicin Uncertain significance
rpoA 3878283 p.Glu75Asp missense_variant 0.16 rifampicin Uncertain significance
rpoA 3878292 c.216T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3878298 c.210A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3878301 c.207C>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3878310 c.198G>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3878313 c.195G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3878322 c.186A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3878331 c.177A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3878337 c.171T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3878346 c.162T>C synonymous_variant 0.16 rifampicin
rpoA 3878358 c.150C>G synonymous_variant 0.16 rifampicin
rpoA 3878361 c.147G>A synonymous_variant 0.17 rifampicin
rpoA 3878364 c.144A>C synonymous_variant 0.18 rifampicin
rpoA 3878370 c.138T>C synonymous_variant 0.21 rifampicin
rpoA 3878385 c.123C>G synonymous_variant 0.21 rifampicin
rpoA 3878391 c.117T>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoA 3878394 c.114G>C synonymous_variant 0.21 rifampicin
rpoA 3878400 c.108T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoA 3878409 c.99C>G synonymous_variant 0.21 rifampicin
rpoA 3878415 c.93C>T synonymous_variant 0.2 rifampicin
rpoA 3878421 c.87A>C synonymous_variant 0.18 rifampicin
rpoA 3878442 c.66G>C synonymous_variant 0.16 rifampicin
rpoA 3878449 p.Gln20Arg missense_variant 0.16 rifampicin
rpoA 3878454 c.54A>C synonymous_variant 0.15 rifampicin
rpoA 3878655 c.-148C>T upstream_gene_variant 1.0 rifampicin
clpC1 4040069 c.636G>C synonymous_variant 0.19 pyrazinamide
clpC1 4040081 c.624C>G synonymous_variant 0.18 pyrazinamide
clpC1 4040087 c.618G>C synonymous_variant 0.17 pyrazinamide
clpC1 4040090 c.613_615delTCTinsAGC synonymous_variant 0.17 pyrazinamide
clpC1 4040093 c.612C>G synonymous_variant 0.18 pyrazinamide Not assoc w R - Interim
clpC1 4040147 c.558A>G synonymous_variant 0.21 pyrazinamide Not assoc w R - Interim
clpC1 4040159 c.546G>C synonymous_variant 0.22 pyrazinamide
clpC1 4040162 c.543G>T synonymous_variant 0.21 pyrazinamide Not assoc w R - Interim
clpC1 4040165 c.540G>C synonymous_variant 0.21 pyrazinamide
clpC1 4040168 c.537G>C synonymous_variant 0.21 pyrazinamide
clpC1 4040171 c.534C>G synonymous_variant 0.21 pyrazinamide
clpC1 4040200 c.505T>C synonymous_variant 0.18 pyrazinamide
clpC1 4040201 c.504C>G synonymous_variant 0.18 pyrazinamide
clpC1 4040204 c.501G>C synonymous_variant 0.17 pyrazinamide
clpC1 4040207 c.498T>C synonymous_variant 0.17 pyrazinamide
clpC1 4040213 p.Ser164Asn missense_variant 0.17 pyrazinamide
clpC1 4040219 c.486C>G synonymous_variant 0.17 pyrazinamide
clpC1 4040225 c.480A>C synonymous_variant 0.18 pyrazinamide
clpC1 4040228 c.477G>C synonymous_variant 0.2 pyrazinamide
clpC1 4040237 c.468C>T synonymous_variant 0.21 pyrazinamide
clpC1 4040249 c.456A>G synonymous_variant 0.24 pyrazinamide
clpC1 4040267 c.438A>G synonymous_variant 0.26 pyrazinamide Not assoc w R - Interim
clpC1 4040273 c.432T>C synonymous_variant 0.22 pyrazinamide Not assoc w R - Interim
clpC1 4040277 c.427_428delTCinsAG synonymous_variant 0.2 pyrazinamide
clpC1 4040279 c.426C>G synonymous_variant 0.21 pyrazinamide Not assoc w R - Interim
clpC1 4040306 c.399G>C synonymous_variant 0.17 pyrazinamide
clpC1 4040309 c.396C>G synonymous_variant 0.15 pyrazinamide Not assoc w R - Interim
clpC1 4040315 c.390G>A synonymous_variant 0.15 pyrazinamide
panD 4044872 c.-591C>T upstream_gene_variant 1.0 pyrazinamide
glpK 4138622 c.1134C>T synonymous_variant 1.0 ethambutol Not assoc w R
moxifloxacin Not assoc w R
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R
rifampicin Not assoc w R
isoniazid Not assoc w R
embC 4242075 p.Arg738Gln missense_variant 1.0 ethambutol Not assoc w R
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
embA 4244350 p.Leu373Pro missense_variant 1.0 ethambutol Uncertain significance
embB 4247028 p.Leu172Arg missense_variant 0.23 ethambutol
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 capreomycin
amikacin
kanamycin
gid 4407588 c.615A>G synonymous_variant 1.0 streptomycin Not assoc w R