TB-Profiler result

Run: SRR6046521
Summary

Run ID: SRR6046521

Sample name:

Date: 2024-10-04T00:50:32.676189

Number of reads: 3239889

Percentage reads mapped: 72.42

Median coverage: 81.0

Strain: lineage4.4.1.1

Spoligotype:

Drug-resistance: Other

Download CSV Download TXT Download JSON
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage4.4.1 Euro-American (S-type) None 0.98
lineage4 Euro-American None 0.99
lineage4.4.1.1 Euro-American None 1.0
lineage4.4 Euro-American None 0.98
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol embB p.Ala356Val Uncertain significance Mutation from literature
pyrazinamide
streptomycin rrs n.888G>A Uncertain significance Mutation from literature
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin rrs n.1402C>A Uncertain significance Mutation from literature
capreomycin rrs n.1402C>A Uncertain significance Mutation from literature
kanamycin rrs n.1402C>A Uncertain significance Mutation from literature
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
rrs 1472733 n.888G>A non_coding_transcript_exon_variant 0.73 streptomycin Uncertain significance Mutation from literature
rrs 1473247 n.1402C>A non_coding_transcript_exon_variant 0.15 amikacin Uncertain significance Mutation from literature
capreomycin Uncertain significance Mutation from literature
kanamycin Uncertain significance Mutation from literature
embB 4247580 p.Ala356Val missense_variant 0.13 ethambutol Uncertain significance Mutation from literature
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
gyrA 6670 c.-632G>C upstream_gene_variant 0.15 levofloxacin
moxifloxacin
gyrA 6673 c.-629A>C upstream_gene_variant 0.16 levofloxacin
moxifloxacin
gyrA 6676 c.-626T>G upstream_gene_variant 0.17 levofloxacin
moxifloxacin
gyrA 6700 c.-602T>C upstream_gene_variant 0.16 levofloxacin
moxifloxacin
gyrA 6703 c.-599G>C upstream_gene_variant 0.14 levofloxacin
moxifloxacin
gyrA 6709 c.-593A>G upstream_gene_variant 0.14 levofloxacin
moxifloxacin
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7406 c.105G>C synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 7427 c.126G>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 7442 c.141G>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 7451 c.150C>G synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 7457 c.156T>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 7475 c.174A>G synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7480 p.Phe60Tyr missense_variant 0.22 levofloxacin
moxifloxacin
gyrA 7484 c.183T>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 7514 c.213C>G synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 7523 c.222C>A synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 7532 c.231T>C synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7541 c.240C>G synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7547 c.246C>T synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7562 c.261C>T synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 7571 c.270G>C synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7595 c.294C>G synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 7601 c.300C>G synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7622 c.321C>T synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 7625 c.324G>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 7631 c.330G>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 7637 c.336C>G synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 7658 c.357A>G synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 7664 c.363T>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 7670 c.369A>G synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 7676 c.375G>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 7683 c.382_384delAGGinsCGC synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 7694 c.393A>G synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 7697 c.396C>A synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 7710 c.409_411delTTGinsCTC synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 7715 c.414G>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 7721 c.420G>A synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7725 c.424C>T synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7728 c.427_429delAGGinsCGT synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8561 c.1260A>C synonymous_variant 0.13 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8588 c.1287G>A synonymous_variant 0.14 levofloxacin
moxifloxacin
gyrA 8603 c.1302A>G synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8619 c.1318T>C synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8624 c.1323G>C synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 8636 c.1335A>C synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8642 c.1341A>G synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8672 c.1371A>G synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8786 c.1485T>C synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 8801 c.1500G>C synonymous_variant 0.31 levofloxacin
moxifloxacin
gyrA 8807 c.1506C>T synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 8810 c.1509A>G synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 8816 c.1515C>G synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 8818 p.Ser506Asn missense_variant 0.28 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8828 c.1527T>C synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 8829 c.1528T>C synonymous_variant 0.27 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8852 c.1551T>C synonymous_variant 0.32 levofloxacin
moxifloxacin
gyrA 8867 c.1566A>G synonymous_variant 0.25 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8870 c.1569G>C synonymous_variant 0.25 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8873 c.1572A>C synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8891 c.1590G>A synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8897 c.1596T>C synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8903 c.1602T>C synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8933 c.1632G>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8946 c.1645_1647delTTGinsCTC synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8966 c.1665C>G synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8967 p.Ala556Arg missense_variant 0.17 levofloxacin
moxifloxacin
gyrA 9119 c.1818A>G synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 9122 c.1821C>A synonymous_variant 0.14 levofloxacin
moxifloxacin
gyrA 9143 c.1842T>C synonymous_variant 0.15 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9304 p.Gly668Asp missense_variant 0.95 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9726 p.Gly809Ser missense_variant 0.98 levofloxacin
moxifloxacin
mshA 575779 c.432A>G synonymous_variant 0.17 isoniazid
ethionamide
mshA 575782 c.435G>C synonymous_variant 0.16 isoniazid
ethionamide
mshA 575809 c.462C>T synonymous_variant 0.22 isoniazid
ethionamide
mshA 575812 c.465C>T synonymous_variant 0.23 isoniazid
ethionamide
mshA 575821 c.474G>C synonymous_variant 0.28 isoniazid
ethionamide
mshA 575824 c.477T>G synonymous_variant 0.29 isoniazid
ethionamide
mshA 575830 c.483C>G synonymous_variant 0.31 isoniazid
ethionamide
mshA 575833 c.486C>G synonymous_variant 0.31 isoniazid
ethionamide
mshA 575845 c.498C>T synonymous_variant 0.29 isoniazid Not assoc w R - Interim
ethionamide
mshA 575884 c.537G>C synonymous_variant 0.31 isoniazid
ethionamide
mshA 575887 c.540G>C synonymous_variant 0.29 isoniazid
ethionamide
mshA 575893 c.546C>G synonymous_variant 0.29 isoniazid
ethionamide
mshA 575896 c.549G>C synonymous_variant 0.31 isoniazid
ethionamide
mshA 575908 c.561A>G synonymous_variant 0.23 isoniazid
ethionamide
mshA 575917 p.Asp190Glu missense_variant 0.19 isoniazid
ethionamide
mshA 575920 c.573C>G synonymous_variant 0.21 isoniazid
ethionamide
mshA 575924 p.Gly193Ser missense_variant 0.17 isoniazid
ethionamide
mshA 575944 c.597T>C synonymous_variant 0.15 isoniazid
ethionamide
ccsA 619552 c.-339A>G upstream_gene_variant 0.15 kanamycin
capreomycin
amikacin
ccsA 619555 c.-336C>G upstream_gene_variant 0.16 kanamycin
capreomycin
amikacin
ccsA 619561 c.-330G>C upstream_gene_variant 0.14 kanamycin
capreomycin
amikacin
ccsA 620295 c.405G>T synonymous_variant 0.13 kanamycin
capreomycin
amikacin
ccsA 620310 c.420C>T synonymous_variant 0.15 kanamycin
capreomycin
amikacin
ccsA 620317 p.Val143Leu missense_variant 0.15 kanamycin
capreomycin
amikacin
ccsA 620340 c.450C>G synonymous_variant 0.14 kanamycin
capreomycin
amikacin
ccsA 620346 c.456C>G synonymous_variant 0.15 kanamycin
capreomycin
amikacin
hadA 731792 c.-138G>A upstream_gene_variant 0.2 isoniazid
nusG 734376 c.123G>A synonymous_variant 0.19 rifampicin
nusG 734407 p.Val52Ile missense_variant 0.2 rifampicin
nusG 734421 c.168A>G synonymous_variant 0.24 rifampicin
nusG 734424 c.171G>A synonymous_variant 0.23 rifampicin
nusG 734442 c.189G>A synonymous_variant 0.24 rifampicin
nusG 734451 c.198G>C synonymous_variant 0.25 rifampicin
nusG 734457 c.204C>G synonymous_variant 0.25 rifampicin
nusG 734472 c.219T>C synonymous_variant 0.24 rifampicin
nusG 734475 c.222T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
nusG 734532 c.279A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
nusG 734556 c.303C>T synonymous_variant 0.17 rifampicin
nusG 734559 c.306T>C synonymous_variant 0.17 rifampicin
rpoB 760139 c.333A>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 760142 c.336C>G synonymous_variant 0.14 rifampicin
rpoB 760181 c.375T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760184 c.378A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760196 c.390C>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760223 c.417T>C synonymous_variant 0.14 rifampicin
rpoB 760340 c.534G>T synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoB 760361 c.555T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760370 c.564C>G synonymous_variant 0.17 rifampicin
rpoB 760376 p.Asp190Glu missense_variant 0.15 rifampicin Uncertain significance
rpoB 760380 p.Thr192Leu missense_variant 0.15 rifampicin
rpoB 760406 c.600G>C synonymous_variant 0.19 rifampicin
rpoB 760412 c.606C>G synonymous_variant 0.19 rifampicin
rpoB 760424 c.618C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760430 c.624T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760475 c.669A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760481 c.675G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760484 c.678A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760522 p.Ser239Asn missense_variant 0.14 rifampicin Uncertain significance
rpoB 760532 c.726T>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 760591 p.Val262Ala missense_variant 0.23 rifampicin
rpoB 760611 c.805T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760634 c.828T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760661 c.855A>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 760670 c.864G>C synonymous_variant 0.15 rifampicin
rpoB 760674 c.868T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 760679 c.873A>G synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 760683 c.877T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 760718 c.912C>T synonymous_variant 0.18 rifampicin
rpoB 760724 c.918T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760730 c.924T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760751 c.945G>C synonymous_variant 0.15 rifampicin
rpoB 760757 c.951T>C synonymous_variant 0.14 rifampicin
rpoB 760759 p.Val318Ala missense_variant 0.15 rifampicin
rpoB 760769 c.963C>G synonymous_variant 0.16 rifampicin
rpoB 760775 c.969G>C synonymous_variant 0.16 rifampicin
rpoB 760776 c.970_972delTCGinsAGC synonymous_variant 0.16 rifampicin
rpoB 760793 c.987A>G synonymous_variant 0.14 rifampicin
rpoB 760805 c.999G>C synonymous_variant 0.15 rifampicin
rpoB 760946 c.1140A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760982 c.1176G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760985 c.1179G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760991 c.1185G>C synonymous_variant 0.24 rifampicin
rpoB 761006 c.1200C>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 761015 c.1209G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 761021 c.1215G>C synonymous_variant 0.25 rifampicin
rpoB 761027 c.1221A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 761036 c.1230G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 761037 c.1231T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 761057 c.1251G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 761102 c.1296A>G synonymous_variant 0.29 rifampicin
rpoB 761129 c.1323G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761132 c.1326G>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761133 c.1327T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 761150 c.1344A>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 761153 c.1347G>C synonymous_variant 0.19 rifampicin
rpoB 761165 c.1359G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 761180 c.1374A>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761189 c.1383T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 761195 c.1389G>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 761255 c.1449T>G synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 761261 c.1455G>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761306 c.1500C>G synonymous_variant 0.18 rifampicin
rpoB 761312 c.1506G>C synonymous_variant 0.16 rifampicin
rpoB 761327 c.1521A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 761330 c.1524G>C synonymous_variant 0.18 rifampicin
rpoB 761354 c.1548C>T synonymous_variant 0.21 rifampicin
rpoB 761408 c.1602G>C synonymous_variant 0.18 rifampicin
rpoB 761414 c.1608A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 761510 c.1704T>C synonymous_variant 0.19 rifampicin
rpoB 761537 c.1731C>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 761570 c.1764T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 761573 c.1767C>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 761579 c.1773G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761588 c.1782C>T synonymous_variant 0.16 rifampicin
rpoB 761606 c.1800C>G synonymous_variant 0.15 rifampicin
rpoB 762008 c.2202C>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 762014 c.2208C>T synonymous_variant 0.2 rifampicin
rpoB 762017 c.2211A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 762053 c.2247T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 762062 c.2256T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 762083 c.2277T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 762086 c.2280G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 762101 c.2295C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 762114 p.Ile770Val missense_variant 0.25 rifampicin Uncertain significance
rpoB 762131 c.2325C>G synonymous_variant 0.22 rifampicin
rpoB 762140 c.2334G>C synonymous_variant 0.19 rifampicin
rpoB 762143 c.2337T>C synonymous_variant 0.22 rifampicin
rpoB 762149 c.2343G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 762167 c.2361T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 762176 c.2370T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 762185 c.2379G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 762206 c.2400C>G synonymous_variant 0.17 rifampicin
rpoB 762293 c.2487T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 762317 c.2511A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 762329 c.2523G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 762338 c.2532T>C synonymous_variant 0.2 rifampicin
rpoB 762347 c.2541T>C synonymous_variant 0.21 rifampicin
rpoB 762362 p.Glu852Asp missense_variant 0.21 rifampicin
rpoB 762369 c.2563T>C synonymous_variant 0.23 rifampicin
rpoC 762398 c.-972T>C upstream_gene_variant 0.16 rifampicin
rpoC 762401 c.-969G>C upstream_gene_variant 0.17 rifampicin
rpoB 762404 c.2598T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 762410 c.-960T>C upstream_gene_variant 0.24 rifampicin
rpoB 762416 c.2610A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 762419 c.-951C>G upstream_gene_variant 0.27 rifampicin
rpoC 762434 c.-936T>C upstream_gene_variant 0.24 rifampicin
rpoB 762449 c.2643C>A synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 762467 c.-903C>T upstream_gene_variant 0.22 rifampicin
rpoB 762488 c.2682G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 762489 p.Val895Gln missense_variant 0.18 rifampicin
rpoC 762509 c.-861T>G upstream_gene_variant 0.22 rifampicin
rpoB 762510 p.Ala902Pro missense_variant 0.22 rifampicin Uncertain significance
rpoC 762521 c.-849C>T upstream_gene_variant 0.2 rifampicin
rpoC 762533 c.-837T>C upstream_gene_variant 0.17 rifampicin
rpoC 762536 c.-834T>C upstream_gene_variant 0.16 rifampicin
rpoC 762537 c.-833T>C upstream_gene_variant 0.16 rifampicin
rpoC 762551 c.-819C>G upstream_gene_variant 0.14 rifampicin
rpoB 762818 c.3012C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 762827 c.3021G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 762857 c.3051C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 762860 c.3054G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 762863 c.3057T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 762929 c.3123G>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 762989 c.-381G>C upstream_gene_variant 0.19 rifampicin
rpoB 762995 c.3189G>T synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 763013 c.-357C>G upstream_gene_variant 0.14 rifampicin
rpoC 763025 c.-345C>T upstream_gene_variant 0.14 rifampicin
rpoB 763028 c.3222T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 763034 c.3228C>G synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoB 763040 c.3234C>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 763070 c.3264T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 763085 c.3279C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 763115 c.3309T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 763136 c.3330C>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 763148 c.-222G>C upstream_gene_variant 0.17 rifampicin
rpoC 763158 c.-212C>T upstream_gene_variant 0.19 rifampicin
rpoB 763166 c.3360A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 763528 c.159G>A synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 763573 c.204G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 763594 c.225C>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 763603 c.234C>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 763636 c.267T>C synonymous_variant 0.16 rifampicin
rpoC 763660 c.291T>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 763675 c.306C>G synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoC 763774 c.405G>C synonymous_variant 0.14 rifampicin
rpoC 763807 c.438T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 763816 c.447C>G synonymous_variant 0.24 rifampicin
rpoC 763835 p.Ala156Met missense_variant 0.26 rifampicin
rpoC 763853 p.Val162Ile missense_variant 0.24 rifampicin
rpoC 763858 c.489A>G synonymous_variant 0.24 rifampicin
rpoC 764131 c.762T>C synonymous_variant 0.16 rifampicin
rpoC 764140 c.771C>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764188 c.819A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764195 p.Ser276Ile missense_variant 0.17 rifampicin
rpoC 764203 c.834G>C synonymous_variant 0.17 rifampicin
rpoC 764206 c.837T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764215 c.846A>G synonymous_variant 0.2 rifampicin
rpoC 764236 c.867G>A synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764248 c.879C>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764257 c.888G>C synonymous_variant 0.18 rifampicin
rpoC 764272 c.903G>C synonymous_variant 0.2 rifampicin
rpoC 764278 c.909A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764338 c.969G>A synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764353 c.984G>C synonymous_variant 0.18 rifampicin
rpoC 764752 c.1383G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764764 c.1395T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764809 c.1440C>T synonymous_variant 0.16 rifampicin Not assoc w R
rpoC 764815 c.1446A>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 764932 c.1563C>A synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 764935 c.1566T>C synonymous_variant 0.15 rifampicin
rpoC 764948 c.1579T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764968 c.1599T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764995 c.1626C>G synonymous_variant 0.18 rifampicin Not assoc w R
rpoC 765019 c.1650A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 765034 c.1665T>C synonymous_variant 0.2 rifampicin
rpoC 765040 c.1671T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 765041 c.1672T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 765047 c.1678T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 765053 c.1684_1685delTCinsAG synonymous_variant 0.14 rifampicin
rpoC 765383 p.Met672Leu missense_variant 0.14 rifampicin Uncertain significance
rpoC 765404 p.Leu679Val missense_variant 0.17 rifampicin
rpoC 765409 c.2040T>C synonymous_variant 0.15 rifampicin
rpoC 765421 c.2052C>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 765478 c.2109T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 765499 c.2130C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 765529 c.2160C>T synonymous_variant 0.22 rifampicin
rpoC 765541 c.2172C>G synonymous_variant 0.19 rifampicin
rpoC 765553 c.2184C>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 765556 c.2187G>C synonymous_variant 0.18 rifampicin
rpoC 765559 c.2190G>C synonymous_variant 0.18 rifampicin
rpoC 765580 c.2211G>C synonymous_variant 0.2 rifampicin
rpoC 765613 p.His748Gln missense_variant 0.23 rifampicin
rpoC 765625 c.2256C>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 765631 p.Asp754Glu missense_variant 0.24 rifampicin
rpoC 765700 c.2331T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 765734 c.2365T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 765811 c.2442T>C synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoC 765883 c.2514C>G synonymous_variant 0.14 rifampicin
rpoC 765886 c.2517C>G synonymous_variant 0.15 rifampicin
rpoC 765892 c.2523T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 765967 c.2598C>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 765982 c.2613C>G synonymous_variant 0.2 rifampicin
rpoC 765994 c.2625A>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 766010 p.Ser881Thr missense_variant 0.13 rifampicin
rpoC 766043 p.Gln892Glu missense_variant 0.15 rifampicin
rpoC 766054 c.2685C>G synonymous_variant 0.16 rifampicin
rpoC 766540 p.Asp1057Glu missense_variant 0.15 rifampicin
rpoC 766630 c.3261G>C synonymous_variant 0.15 rifampicin
rpoC 766660 c.3291G>C synonymous_variant 0.14 rifampicin
rpoC 766672 c.3303T>C synonymous_variant 0.14 rifampicin
rpoC 766673 p.Gly1102Asn missense_variant 0.15 rifampicin
rpoC 766726 c.3357T>C synonymous_variant 0.19 rifampicin
rpoC 766738 c.3369G>C synonymous_variant 0.16 rifampicin
rpoC 766774 c.3405T>C synonymous_variant 0.15 rifampicin
rpoC 766801 c.3432C>G synonymous_variant 0.14 rifampicin
rpoC 766804 c.3435A>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 766861 c.3492G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 766864 c.3495G>C synonymous_variant 0.21 rifampicin
rpoC 766876 c.3507C>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 766882 c.3513C>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 766894 c.3525T>C synonymous_variant 0.25 rifampicin
rpoC 766895 c.3526T>C synonymous_variant 0.24 rifampicin
rpoC 766900 c.3531T>C synonymous_variant 0.26 rifampicin
rpoC 766933 c.3564A>G synonymous_variant 0.27 rifampicin
rpoC 766945 c.3576A>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 766963 c.3594T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 766972 c.3603G>C synonymous_variant 0.28 rifampicin
rpoC 766996 c.3627C>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 767009 c.3640_3642delTCGinsAGC synonymous_variant 0.24 rifampicin
rpoC 767014 c.3645G>C synonymous_variant 0.23 rifampicin
rpoC 767033 c.3664_3666delTCGinsAGT synonymous_variant 0.23 rifampicin
rpoC 767059 c.3690T>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 767062 c.3693C>A synonymous_variant 0.21 rifampicin
rpoC 767134 c.3765C>A synonymous_variant 0.13 rifampicin
rpoC 767181 p.Ala1271Glu missense_variant 0.13 rifampicin
mmpL5 775639 p.Ile948Val missense_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
mmpL5 776685 p.Ser599Leu missense_variant 1.0 bedaquiline Uncertain significance
clofazimine Uncertain significance
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rplC 800582 c.-227C>G upstream_gene_variant 0.17 linezolid
rplC 800612 c.-197A>G upstream_gene_variant 0.14 linezolid
fbiC 1304142 c.1212G>C synonymous_variant 0.16 pretomanid
delamanid
clofazimine
fbiC 1304691 c.1761G>C synonymous_variant 0.15 pretomanid
delamanid
clofazimine
fbiC 1304694 c.1764A>C synonymous_variant 0.16 pretomanid
delamanid
clofazimine
fbiC 1304703 c.1773C>G synonymous_variant 0.21 pretomanid
delamanid
clofazimine
fbiC 1304711 p.Ala594Glu missense_variant 0.2 pretomanid
delamanid
clofazimine
fbiC 1304715 c.1785G>C synonymous_variant 0.18 pretomanid
delamanid
clofazimine
fbiC 1304724 c.1794A>G synonymous_variant 0.16 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R - Interim
fbiC 1304727 c.1797A>G synonymous_variant 0.16 pretomanid
delamanid
clofazimine
fbiC 1304739 c.1809C>T synonymous_variant 0.15 pretomanid
delamanid
clofazimine
fbiC 1304817 c.1887T>C synonymous_variant 0.14 pretomanid
delamanid
clofazimine
fbiC 1304875 p.Ile649Val missense_variant 0.15 pretomanid
delamanid
clofazimine
fbiC 1304891 p.Ile654Thr missense_variant 0.15 pretomanid
delamanid
clofazimine
fbiC 1304893 p.Gly655Ser missense_variant 0.14 pretomanid
delamanid
clofazimine
fbiC 1304958 c.2028T>G synonymous_variant 0.14 pretomanid
delamanid
clofazimine
fbiC 1304983 c.2053C>T synonymous_variant 0.16 pretomanid
delamanid
clofazimine
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472122 n.277G>T non_coding_transcript_exon_variant 0.5 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472123 n.278A>T non_coding_transcript_exon_variant 0.6 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472124 n.279C>T non_coding_transcript_exon_variant 0.67 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472137 n.292G>A non_coding_transcript_exon_variant 0.36 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472150 n.305T>A non_coding_transcript_exon_variant 0.87 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472151 n.306C>T non_coding_transcript_exon_variant 0.43 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472155 n.310C>T non_coding_transcript_exon_variant 0.32 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472160 n.315C>T non_coding_transcript_exon_variant 0.39 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472172 n.327T>C non_coding_transcript_exon_variant 0.48 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472225 n.380C>A non_coding_transcript_exon_variant 0.76 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472251 n.406G>A non_coding_transcript_exon_variant 0.88 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472258 n.413A>G non_coding_transcript_exon_variant 0.71 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472259 n.414C>A non_coding_transcript_exon_variant 0.82 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472507 n.662C>G non_coding_transcript_exon_variant 0.68 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472517 n.672T>A non_coding_transcript_exon_variant 0.78 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472518 n.673G>T non_coding_transcript_exon_variant 0.78 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472530 n.685G>A non_coding_transcript_exon_variant 0.8 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472537 n.692C>T non_coding_transcript_exon_variant 0.8 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472544 n.699C>A non_coding_transcript_exon_variant 0.82 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472545 n.700A>T non_coding_transcript_exon_variant 0.8 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472549 n.704G>A non_coding_transcript_exon_variant 0.17 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472566 n.721G>A non_coding_transcript_exon_variant 0.81 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472571 n.726G>C non_coding_transcript_exon_variant 0.85 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472579 n.734G>T non_coding_transcript_exon_variant 0.79 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472581 n.736A>T non_coding_transcript_exon_variant 1.0 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472598 n.753A>C non_coding_transcript_exon_variant 0.8 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472599 n.754G>T non_coding_transcript_exon_variant 0.8 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472616 n.771G>A non_coding_transcript_exon_variant 0.16 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472655 n.810G>A non_coding_transcript_exon_variant 0.98 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472658 n.813G>A non_coding_transcript_exon_variant 0.77 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472661 n.816A>G non_coding_transcript_exon_variant 0.8 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472670 n.825G>T non_coding_transcript_exon_variant 0.7 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472673 n.828_838delTTTCCTTCCTTinsATCCTTTCC non_coding_transcript_exon_variant 1.0 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472687 n.843dupT non_coding_transcript_exon_variant 0.73 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472690 n.845C>A non_coding_transcript_exon_variant 0.92 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472697 n.852T>C non_coding_transcript_exon_variant 0.82 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472713 n.868T>C non_coding_transcript_exon_variant 0.76 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472714 n.869A>G non_coding_transcript_exon_variant 0.24 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472716 n.871C>T non_coding_transcript_exon_variant 0.75 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472742 n.897C>T non_coding_transcript_exon_variant 0.75 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472744 n.899A>G non_coding_transcript_exon_variant 0.75 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472781 n.936C>T non_coding_transcript_exon_variant 0.67 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472793 n.948A>T non_coding_transcript_exon_variant 0.71 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472803 n.958T>A non_coding_transcript_exon_variant 0.69 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472824 n.979T>A non_coding_transcript_exon_variant 1.0 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472828 n.983T>C non_coding_transcript_exon_variant 1.0 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472895 n.1050C>T non_coding_transcript_exon_variant 0.64 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472954 n.1109T>C non_coding_transcript_exon_variant 0.57 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472956 n.1111T>C non_coding_transcript_exon_variant 0.79 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472957 n.1112C>T non_coding_transcript_exon_variant 0.79 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472973 n.1128A>G non_coding_transcript_exon_variant 0.67 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472990 n.1145A>G non_coding_transcript_exon_variant 0.67 kanamycin Not assoc w R
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472992 n.1147A>G non_coding_transcript_exon_variant 0.47 kanamycin
capreomycin
streptomycin
amikacin
rrs 1473005 n.1160C>T non_coding_transcript_exon_variant 0.47 kanamycin
capreomycin
streptomycin
amikacin
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.71 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.65 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473172 n.1327T>G non_coding_transcript_exon_variant 0.16 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473173 n.1328C>T non_coding_transcript_exon_variant 0.21 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Not assoc w R
amikacin Not assoc w R
rrs 1473177 n.1332G>A non_coding_transcript_exon_variant 0.14 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1473192 n.1347A>G non_coding_transcript_exon_variant 0.2 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1473199 n.1356delA non_coding_transcript_exon_variant 0.14 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473205 n.1360T>C non_coding_transcript_exon_variant 0.15 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473221 n.1376C>T non_coding_transcript_exon_variant 0.23 kanamycin
capreomycin
streptomycin
amikacin
rrs 1473252 n.1407T>C non_coding_transcript_exon_variant 0.34 kanamycin Not assoc w R
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1473259 n.1414C>T non_coding_transcript_exon_variant 0.38 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1473276 n.1431A>C non_coding_transcript_exon_variant 0.29 kanamycin
capreomycin
streptomycin
amikacin
rrs 1473277 n.1432G>A non_coding_transcript_exon_variant 0.26 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1473290 n.1445C>T non_coding_transcript_exon_variant 0.67 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1473300 n.1455C>T non_coding_transcript_exon_variant 0.24 kanamycin
capreomycin
streptomycin
amikacin
rrs 1473301 n.1456T>G non_coding_transcript_exon_variant 0.26 kanamycin
capreomycin
streptomycin
amikacin
rrs 1473316 n.1471C>T non_coding_transcript_exon_variant 0.36 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473352 n.1507C>T non_coding_transcript_exon_variant 0.17 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Not assoc w R
rrl 1473758 n.101G>T non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid
rrl 1473806 n.149C>T non_coding_transcript_exon_variant 0.57 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 0.83 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474674 n.1017_1018delACinsG non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1474677 n.1020A>G non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474734 n.1077G>T non_coding_transcript_exon_variant 0.83 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474749 n.1092C>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474753 n.1097delC non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474760 n.1103A>G non_coding_transcript_exon_variant 0.8 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474779 n.1122G>A non_coding_transcript_exon_variant 0.8 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474780 n.1123C>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474782 n.1125G>A non_coding_transcript_exon_variant 0.8 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474801 n.1144G>A non_coding_transcript_exon_variant 0.83 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474802 n.1145T>C non_coding_transcript_exon_variant 0.83 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474823 n.1166C>G non_coding_transcript_exon_variant 0.82 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474830 n.1173A>G non_coding_transcript_exon_variant 0.72 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474831 n.1174A>G non_coding_transcript_exon_variant 0.85 capreomycin Uncertain significance
linezolid
rrl 1474832 n.1175A>T non_coding_transcript_exon_variant 0.69 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474864 n.1207C>T non_coding_transcript_exon_variant 0.79 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1475713 n.2056C>G non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475715 n.2058G>C non_coding_transcript_exon_variant 0.39 capreomycin
linezolid
rrl 1475716 n.2059A>G non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475717 n.2060C>G non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1475777 n.2120A>T non_coding_transcript_exon_variant 0.57 capreomycin
linezolid
rrl 1475783 n.2126T>G non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475803 n.2146T>C non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475804 n.2147G>C non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475816 n.2159C>G non_coding_transcript_exon_variant 0.52 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475817 n.2160A>G non_coding_transcript_exon_variant 0.59 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475858 n.2201T>C non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475866 n.2209T>A non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475869 n.2212C>A non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1475874 n.2217C>T non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1475881 n.2224T>C non_coding_transcript_exon_variant 0.44 capreomycin
linezolid
rrl 1475883 n.2226A>C non_coding_transcript_exon_variant 0.93 capreomycin Uncertain significance
linezolid
rrl 1475884 n.2227A>G non_coding_transcript_exon_variant 0.72 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475896 n.2239A>G non_coding_transcript_exon_variant 0.43 capreomycin
linezolid
rrl 1475897 n.2240T>C non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475898 n.2241A>G non_coding_transcript_exon_variant 0.81 capreomycin Uncertain significance
linezolid
rrl 1475899 n.2242G>A non_coding_transcript_exon_variant 0.81 capreomycin Uncertain significance
linezolid
rrl 1475906 n.2249C>T non_coding_transcript_exon_variant 0.48 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475916 n.2259C>G non_coding_transcript_exon_variant 0.83 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475937 n.2280A>T non_coding_transcript_exon_variant 0.73 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475943 n.2286G>A non_coding_transcript_exon_variant 0.73 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475945 n.2288C>A non_coding_transcript_exon_variant 0.45 capreomycin
linezolid
rrl 1475952 n.2295A>G non_coding_transcript_exon_variant 0.71 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475970 n.2313C>T non_coding_transcript_exon_variant 0.6 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475975 n.2318C>T non_coding_transcript_exon_variant 0.67 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475977 n.2320A>G non_coding_transcript_exon_variant 0.67 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.73 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476225 n.2568T>G non_coding_transcript_exon_variant 0.72 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476227 n.2570C>T non_coding_transcript_exon_variant 0.72 capreomycin
linezolid Uncertain significance
rrl 1476229 n.2572C>T non_coding_transcript_exon_variant 0.73 capreomycin Uncertain significance
linezolid
rrl 1476250 n.2593C>G non_coding_transcript_exon_variant 0.73 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476251 n.2594T>C non_coding_transcript_exon_variant 0.69 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476257 n.2600G>C non_coding_transcript_exon_variant 0.75 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476260 n.2603A>G non_coding_transcript_exon_variant 0.81 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476280 n.2623A>C non_coding_transcript_exon_variant 0.79 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476293 n.2636C>T non_coding_transcript_exon_variant 0.7 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476294 n.2637A>G non_coding_transcript_exon_variant 0.74 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476295 n.2638C>G non_coding_transcript_exon_variant 0.73 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476296 n.2639C>T non_coding_transcript_exon_variant 0.74 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476297 n.2640C>T non_coding_transcript_exon_variant 0.69 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476301 n.2644A>T non_coding_transcript_exon_variant 0.58 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476302 n.2645G>A non_coding_transcript_exon_variant 0.67 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476311 n.2654G>C non_coding_transcript_exon_variant 0.73 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476312 n.2655T>C non_coding_transcript_exon_variant 0.74 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476313 n.2656G>A non_coding_transcript_exon_variant 0.7 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476332 n.2675G>C non_coding_transcript_exon_variant 0.72 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476338 n.2681C>T non_coding_transcript_exon_variant 0.71 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476353 n.2696G>T non_coding_transcript_exon_variant 0.73 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476358 n.2701T>C non_coding_transcript_exon_variant 0.71 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476359 n.2702C>G non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476369 n.2712C>T non_coding_transcript_exon_variant 0.63 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476372 n.2715T>C non_coding_transcript_exon_variant 0.66 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476381 n.2724G>C non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476382 n.2725A>G non_coding_transcript_exon_variant 0.64 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476383 n.2726T>A non_coding_transcript_exon_variant 0.69 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476425 n.2768G>T non_coding_transcript_exon_variant 0.55 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476428 n.2771C>T non_coding_transcript_exon_variant 0.83 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476429 n.2772A>C non_coding_transcript_exon_variant 0.57 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476429 n.2772A>T non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid
rrl 1476466 n.2809C>T non_coding_transcript_exon_variant 0.28 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476481 n.2824T>C non_coding_transcript_exon_variant 0.83 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476506 n.2849T>C non_coding_transcript_exon_variant 0.72 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476597 n.2940G>A non_coding_transcript_exon_variant 0.67 capreomycin Uncertain significance
linezolid
rrl 1476603 n.2946G>A non_coding_transcript_exon_variant 0.67 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476608 n.2951C>G non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.47 capreomycin Uncertain significance
linezolid Uncertain significance
rpsA 1833568 c.27G>C synonymous_variant 0.14 pyrazinamide Not assoc w R - Interim
rpsA 1833589 c.48A>T synonymous_variant 0.14 pyrazinamide
rpsA 1833595 c.54T>C synonymous_variant 0.15 pyrazinamide
rpsA 1833661 c.120A>G synonymous_variant 0.2 pyrazinamide
rpsA 1833667 c.126C>G synonymous_variant 0.2 pyrazinamide
rpsA 1833721 c.180A>G synonymous_variant 0.2 pyrazinamide
rpsA 1833724 c.183C>G synonymous_variant 0.2 pyrazinamide
rpsA 1833727 c.186G>C synonymous_variant 0.19 pyrazinamide
rpsA 1833742 c.201A>G synonymous_variant 0.16 pyrazinamide
rpsA 1833745 c.204G>C synonymous_variant 0.18 pyrazinamide
rpsA 1833748 c.207C>G synonymous_variant 0.18 pyrazinamide
rpsA 1833787 c.246C>G synonymous_variant 0.2 pyrazinamide
rpsA 1833790 c.249T>C synonymous_variant 0.22 pyrazinamide
rpsA 1833802 c.261A>G synonymous_variant 0.19 pyrazinamide
rpsA 1833811 c.270G>T synonymous_variant 0.16 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.14 pyrazinamide
rpsA 1833874 c.333T>C synonymous_variant 0.19 pyrazinamide
rpsA 1833886 c.345C>G synonymous_variant 0.2 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.19 pyrazinamide
rpsA 1833940 c.399C>G synonymous_variant 0.18 pyrazinamide
rpsA 1833971 c.430C>T synonymous_variant 0.18 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.15 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.14 pyrazinamide
rpsA 1834021 c.480C>T synonymous_variant 0.17 pyrazinamide
rpsA 1834030 c.489C>G synonymous_variant 0.16 pyrazinamide
rpsA 1834222 c.681T>C synonymous_variant 0.14 pyrazinamide
rpsA 1834234 c.693G>C synonymous_variant 0.16 pyrazinamide
rpsA 1834249 c.708T>C synonymous_variant 0.16 pyrazinamide
rpsA 1834261 c.720A>G synonymous_variant 0.16 pyrazinamide Not assoc w R - Interim
rpsA 1834264 c.723G>C synonymous_variant 0.16 pyrazinamide
rpsA 1834303 c.762T>C synonymous_variant 0.23 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.28 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
rpsA 1834366 c.825A>G synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
rpsA 1834396 c.855G>C synonymous_variant 0.19 pyrazinamide
rpsA 1834411 c.870T>C synonymous_variant 0.17 pyrazinamide
rpsA 1834417 c.876G>C synonymous_variant 0.16 pyrazinamide
rpsA 1834423 c.882G>C synonymous_variant 0.15 pyrazinamide
rpsA 1834435 c.894G>C synonymous_variant 0.18 pyrazinamide
tsnR 1853447 c.-159C>G upstream_gene_variant 0.14 linezolid
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
bacA 2064972 c.-244T>C upstream_gene_variant 0.15 kanamycin
capreomycin
streptomycin
amikacin
bacA 2064978 c.-250G>C upstream_gene_variant 0.13 kanamycin
capreomycin
streptomycin
amikacin
bacA 2064979 c.-251C>T upstream_gene_variant 0.13 kanamycin
capreomycin
streptomycin
amikacin
bacA 2064993 c.-265T>C upstream_gene_variant 0.14 kanamycin
capreomycin
streptomycin
amikacin
ndh 2102990 p.Val18Ala missense_variant 1.0 isoniazid Not assoc w R
delamanid Uncertain significance
ethionamide Uncertain significance
PPE35 2169840 p.Gly258Asp missense_variant 1.0 pyrazinamide Not assoc w R
PPE35 2169914 c.699C>A synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
kasA 2518705 c.591T>C synonymous_variant 0.14 isoniazid
kasA 2518711 c.597A>G synonymous_variant 0.16 isoniazid
kasA 2518714 c.600A>C synonymous_variant 0.16 isoniazid
kasA 2518744 c.630C>T synonymous_variant 0.14 isoniazid
kasA 2518768 c.654C>T synonymous_variant 0.17 isoniazid
kasA 2518777 c.663C>T synonymous_variant 0.15 isoniazid
kasA 2518783 c.669T>C synonymous_variant 0.14 isoniazid
kasA 2518789 c.675G>C synonymous_variant 0.15 isoniazid
kasA 2518792 c.678C>A synonymous_variant 0.16 isoniazid
kasA 2518795 c.681C>G synonymous_variant 0.15 isoniazid
kasA 2519062 c.948T>G synonymous_variant 0.13 isoniazid
kasA 2519068 c.954C>T synonymous_variant 0.17 isoniazid
kasA 2519072 p.Ala320Thr missense_variant 0.16 isoniazid
Rv2477c 2782981 c.1062G>C synonymous_variant 0.13 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783015 p.Ser343Thr missense_variant 0.14 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783035 c.1008G>C synonymous_variant 0.17 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783040 p.Ala335Thr missense_variant 0.16 kanamycin Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
rifampicin Uncertain significance
ethambutol Uncertain significance
amikacin Uncertain significance
Rv2477c 2783044 c.999G>C synonymous_variant 0.16 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783048 p.Asp332Gly missense_variant 0.16 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783059 c.984T>C synonymous_variant 0.15 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783179 c.864G>C synonymous_variant 0.14 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783182 c.861C>G synonymous_variant 0.15 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783185 c.858G>A synonymous_variant 0.15 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783751 p.Ile98Val missense_variant 0.16 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783758 p.Asp95Glu missense_variant 0.16 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783761 c.282G>C synonymous_variant 0.16 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783766 p.Met93Leu missense_variant 0.16 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783776 c.267G>C synonymous_variant 0.15 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783779 c.264T>C synonymous_variant 0.17 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783797 p.Asp82Glu missense_variant 0.15 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783815 c.228A>G synonymous_variant 0.15 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783821 p.Gln74Leu missense_variant 0.15 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
ribD 2987614 c.776G>A splice_region_variant&stop_retained_variant 1.0 para-aminosalicylic_acid
thyX 3067349 c.597G>C synonymous_variant 0.17 para-aminosalicylic_acid
thyX 3067355 c.591A>C synonymous_variant 0.17 para-aminosalicylic_acid
thyX 3067367 c.579G>C synonymous_variant 0.13 para-aminosalicylic_acid
thyX 3067376 c.570G>A synonymous_variant 0.13 para-aminosalicylic_acid
thyX 3067545 p.Glu134Ala missense_variant 0.15 para-aminosalicylic_acid
thyX 3067549 p.Thr133Ala missense_variant 0.13 para-aminosalicylic_acid
thyX 3067765 p.Leu61Ile missense_variant 0.13 para-aminosalicylic_acid
thyX 3067781 c.165C>A synonymous_variant 0.13 para-aminosalicylic_acid
thyX 3067802 c.144C>G synonymous_variant 0.14 para-aminosalicylic_acid
thyX 3067850 c.96A>C synonymous_variant 0.15 para-aminosalicylic_acid
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
Rv3083 3448608 c.105G>A synonymous_variant 1.0 ethionamide Not assoc w R - Interim
Rv3236c 3612665 p.Val151Ala missense_variant 1.0 pyrazinamide Not assoc w R
mtrB 3625065 p.Met517Leu missense_variant 1.0 rifampicin Not assoc w R
bedaquiline Uncertain significance
lpqB 3625663 c.-753G>C upstream_gene_variant 0.18 rifampicin
bedaquiline
lpqB 3625669 c.-759G>C upstream_gene_variant 0.18 rifampicin
bedaquiline
lpqB 3625687 c.-777G>C upstream_gene_variant 0.16 rifampicin
bedaquiline
lpqB 3625690 c.-780T>C upstream_gene_variant 0.15 rifampicin
bedaquiline
lpqB 3625696 c.-786A>G upstream_gene_variant 0.15 rifampicin
bedaquiline
mtrB 3625705 c.909C>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
bedaquiline
mtrA 3627227 c.123T>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
bedaquiline
rpoA 3877839 c.669G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoA 3878785 c.-278T>G upstream_gene_variant 0.15 rifampicin
rpoA 3878788 c.-281G>C upstream_gene_variant 0.15 rifampicin Uncertain significance
rpoA 3878806 c.-299C>G upstream_gene_variant 0.14 rifampicin
rpoA 3878809 c.-302T>C upstream_gene_variant 0.14 rifampicin
rpoA 3878853 c.-346G>A upstream_gene_variant 0.14 rifampicin
rpoA 3878860 c.-353C>T upstream_gene_variant 0.17 rifampicin
rpoA 3878878 c.-371T>C upstream_gene_variant 0.18 rifampicin Uncertain significance
rpoA 3878909 c.-402A>G upstream_gene_variant 0.24 rifampicin
rpoA 3878914 c.-407T>C upstream_gene_variant 0.23 rifampicin Uncertain significance
rpoA 3878917 c.-410G>A upstream_gene_variant 0.19 rifampicin Uncertain significance
rpoA 3878938 c.-431T>A upstream_gene_variant 0.24 rifampicin
rpoA 3878947 c.-440G>C upstream_gene_variant 0.23 rifampicin Uncertain significance
rpoA 3879140 c.-633A>T upstream_gene_variant 0.93 rifampicin
clpC1 4038407 c.2298G>C synonymous_variant 0.19 pyrazinamide
clpC1 4038419 c.2286T>C synonymous_variant 0.21 pyrazinamide
clpC1 4038433 c.2272C>T synonymous_variant 0.19 pyrazinamide
clpC1 4038434 c.2271G>A synonymous_variant 0.19 pyrazinamide
clpC1 4038444 p.Ala754Lys missense_variant 0.16 pyrazinamide
clpC1 4038446 c.2259T>C synonymous_variant 0.16 pyrazinamide
clpC1 4038456 p.Val750Glu missense_variant 0.16 pyrazinamide
clpC1 4038460 p.Leu749Met missense_variant 0.16 pyrazinamide
clpC1 4038486 p.Gly740Asn missense_variant 0.14 pyrazinamide
clpC1 4038489 p.Ala739Gly missense_variant 0.14 pyrazinamide
clpC1 4038494 c.2211G>C synonymous_variant 0.14 pyrazinamide
clpC1 4038497 p.Ser736Gln missense_variant 0.13 pyrazinamide
clpC1 4038530 p.Glu725Asp missense_variant 0.17 pyrazinamide
clpC1 4038596 c.2109A>G synonymous_variant 0.21 pyrazinamide
clpC1 4038623 c.2082A>G synonymous_variant 0.18 pyrazinamide
clpC1 4038640 p.Asp689Asn missense_variant 0.21 pyrazinamide
clpC1 4038653 c.2052C>T synonymous_variant 0.19 pyrazinamide
clpC1 4038658 p.Lys683Gln missense_variant 0.17 pyrazinamide
clpC1 4038661 p.Ser682Thr missense_variant 0.17 pyrazinamide
clpC1 4038662 c.2043T>C synonymous_variant 0.17 pyrazinamide
clpC1 4038671 c.2034T>C synonymous_variant 0.19 pyrazinamide
clpC1 4038683 c.2022T>C synonymous_variant 0.15 pyrazinamide Not assoc w R - Interim
clpC1 4038749 c.1956C>G synonymous_variant 0.15 pyrazinamide
clpC1 4038755 c.1950G>T synonymous_variant 0.17 pyrazinamide
clpC1 4038770 c.1935C>T synonymous_variant 0.18 pyrazinamide
clpC1 4038773 c.1932T>C synonymous_variant 0.19 pyrazinamide
clpC1 4038782 c.1923G>C synonymous_variant 0.17 pyrazinamide
clpC1 4038812 c.1893T>C synonymous_variant 0.17 pyrazinamide
clpC1 4038821 c.1884G>A synonymous_variant 0.21 pyrazinamide
clpC1 4038845 c.1860G>C synonymous_variant 0.26 pyrazinamide
clpC1 4038860 c.1845G>C synonymous_variant 0.33 pyrazinamide Not assoc w R - Interim
clpC1 4038878 c.1827A>G synonymous_variant 0.33 pyrazinamide Not assoc w R - Interim
clpC1 4038908 c.1797C>G synonymous_variant 0.29 pyrazinamide
clpC1 4038914 c.1791G>C synonymous_variant 0.29 pyrazinamide
clpC1 4038923 c.1780_1782delCTAinsTTG synonymous_variant 0.29 pyrazinamide
clpC1 4038953 c.1752A>G synonymous_variant 0.23 pyrazinamide
clpC1 4038956 c.1749T>C synonymous_variant 0.23 pyrazinamide
clpC1 4038965 c.1740T>C synonymous_variant 0.22 pyrazinamide
clpC1 4038971 c.1734T>C synonymous_variant 0.19 pyrazinamide
clpC1 4038974 c.1731T>C synonymous_variant 0.23 pyrazinamide Not assoc w R - Interim
clpC1 4038989 c.1716T>C synonymous_variant 0.24 pyrazinamide
clpC1 4038997 c.1708T>C synonymous_variant 0.22 pyrazinamide Not assoc w R - Interim
clpC1 4039004 c.1701C>G synonymous_variant 0.21 pyrazinamide
clpC1 4039022 c.1683A>G synonymous_variant 0.18 pyrazinamide
clpC1 4039295 c.1410A>C synonymous_variant 0.18 pyrazinamide
clpC1 4039298 c.1407T>C synonymous_variant 0.18 pyrazinamide
clpC1 4039319 c.1386T>C synonymous_variant 0.15 pyrazinamide Not assoc w R - Interim
clpC1 4039322 c.1383T>C synonymous_variant 0.14 pyrazinamide
clpC1 4039328 c.1377A>C synonymous_variant 0.14 pyrazinamide
clpC1 4039338 p.Thr456Gln missense_variant 0.13 pyrazinamide
clpC1 4039349 c.1356C>T synonymous_variant 0.14 pyrazinamide
clpC1 4039352 c.1353C>G synonymous_variant 0.13 pyrazinamide
clpC1 4039364 c.1341C>G synonymous_variant 0.15 pyrazinamide
clpC1 4039409 c.1296T>C synonymous_variant 0.18 pyrazinamide
clpC1 4039481 c.1224T>G synonymous_variant 0.27 pyrazinamide Not assoc w R - Interim
clpC1 4039517 c.1188C>G synonymous_variant 0.24 pyrazinamide
clpC1 4039570 p.Met379Leu missense_variant 0.24 pyrazinamide Uncertain significance
clpC1 4039576 p.Ala377Pro missense_variant 0.26 pyrazinamide
clpC1 4039577 c.1128T>C synonymous_variant 0.26 pyrazinamide Not assoc w R - Interim
clpC1 4039589 c.1116G>C synonymous_variant 0.28 pyrazinamide
clpC1 4039610 c.1095G>C synonymous_variant 0.28 pyrazinamide
clpC1 4039616 c.1089G>C synonymous_variant 0.24 pyrazinamide
clpC1 4039622 c.1083C>T synonymous_variant 0.24 pyrazinamide
clpC1 4039625 c.1080G>A synonymous_variant 0.23 pyrazinamide
clpC1 4039661 c.1044T>G synonymous_variant 0.2 pyrazinamide
clpC1 4039664 c.1041G>C synonymous_variant 0.2 pyrazinamide
clpC1 4039694 c.1011G>C synonymous_variant 0.24 pyrazinamide
clpC1 4039724 c.981A>G synonymous_variant 0.19 pyrazinamide
clpC1 4039790 c.915C>G synonymous_variant 0.22 pyrazinamide
clpC1 4039817 c.888A>C synonymous_variant 0.16 pyrazinamide Not assoc w R - Interim
clpC1 4039820 c.885T>G synonymous_variant 0.16 pyrazinamide
clpC1 4039826 c.879C>G synonymous_variant 0.17 pyrazinamide
clpC1 4039831 c.874T>C synonymous_variant 0.18 pyrazinamide
clpC1 4039850 c.855T>C synonymous_variant 0.23 pyrazinamide
clpC1 4039865 c.840T>C synonymous_variant 0.2 pyrazinamide
clpC1 4039898 c.807C>G synonymous_variant 0.2 pyrazinamide
clpC1 4039928 c.775_777delAGCinsTCG synonymous_variant 0.16 pyrazinamide
clpC1 4039931 c.774T>C synonymous_variant 0.15 pyrazinamide
clpC1 4039937 c.768G>C synonymous_variant 0.16 pyrazinamide
clpC1 4039946 c.759A>C synonymous_variant 0.18 pyrazinamide
clpC1 4039952 c.753T>C synonymous_variant 0.18 pyrazinamide
clpC1 4039979 c.726C>G synonymous_variant 0.2 pyrazinamide
clpC1 4039988 c.717C>G synonymous_variant 0.19 pyrazinamide
clpC1 4039991 c.714G>C synonymous_variant 0.17 pyrazinamide
clpC1 4040267 c.438A>G synonymous_variant 0.25 pyrazinamide Not assoc w R - Interim
clpC1 4040273 c.432T>C synonymous_variant 0.24 pyrazinamide Not assoc w R - Interim
clpC1 4040277 c.427_428delTCinsAG synonymous_variant 0.24 pyrazinamide
clpC1 4040279 c.426C>G synonymous_variant 0.24 pyrazinamide Not assoc w R - Interim
clpC1 4040291 c.414G>C synonymous_variant 0.24 pyrazinamide
clpC1 4040318 c.387C>G synonymous_variant 0.26 pyrazinamide
clpC1 4040330 c.375C>G synonymous_variant 0.24 pyrazinamide
clpC1 4040342 c.363C>G synonymous_variant 0.22 pyrazinamide
clpC1 4040354 c.351A>G synonymous_variant 0.19 pyrazinamide
clpC1 4040363 c.342A>T synonymous_variant 0.18 pyrazinamide
clpC1 4040501 c.204C>T synonymous_variant 0.14 pyrazinamide Not assoc w R - Interim
panD 4044737 c.-456T>C upstream_gene_variant 0.17 pyrazinamide
panD 4044758 c.-477C>T upstream_gene_variant 0.14 pyrazinamide
panD 4044779 c.-500_-498delCTAinsTGC upstream_gene_variant 0.13 pyrazinamide
panD 4044800 c.-519C>G upstream_gene_variant 0.15 pyrazinamide
panD 4044812 c.-531A>C upstream_gene_variant 0.18 pyrazinamide
panD 4044818 c.-538_-537delCGinsAC upstream_gene_variant 0.17 pyrazinamide
panD 4044823 c.-542G>C upstream_gene_variant 0.16 pyrazinamide
embC 4238963 c.-900C>T upstream_gene_variant 1.0 ethambutol Not assoc w R
embC 4240699 c.837C>G synonymous_variant 0.15 ethambutol Not assoc w R - Interim
embC 4241095 c.1233C>T synonymous_variant 0.14 ethambutol
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
embB 4247512 c.999T>C synonymous_variant 0.15 ethambutol
embB 4247539 c.1026T>C synonymous_variant 0.16 ethambutol
embB 4247566 c.1053C>A synonymous_variant 0.15 ethambutol
embB 4247932 c.1419C>G synonymous_variant 0.14 ethambutol
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 kanamycin
capreomycin
amikacin