TB-Profiler result

Run: SRR29097004
Summary

Run ID: SRR29097004

Sample name:

Date: 2025-02-11T10:56:52.648385

Number of reads: 573155

Percentage reads mapped: 84.98

Median coverage: 16.0

Strain: lineage3

Spoligotype:

Drug-resistance: Other

Download CSV Download TXT Download JSON
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage3 East-African-Indian RD750 0.94
La1.2.BCG M.bovis None 0.07
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol embB p.Asp311Gly Mutation from literature
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
embB 4247445 p.Asp311Gly missense_variant 0.62 ethambutol Mutation from literature
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
dnaA 805 c.805T>C synonymous_variant 0.29 isoniazid
dnaA 822 c.822A>G synonymous_variant 0.32 isoniazid
dnaA 828 c.828T>C synonymous_variant 0.33 isoniazid Not assoc w R - Interim
dnaA 837 c.837A>G synonymous_variant 0.33 isoniazid
dnaA 840 c.840G>A synonymous_variant 0.33 isoniazid
dnaA 843 c.843T>G synonymous_variant 0.3 isoniazid
dnaA 846 c.846T>C synonymous_variant 0.3 isoniazid
dnaA 849 c.849A>G synonymous_variant 0.3 isoniazid
dnaA 876 c.876C>G synonymous_variant 0.31 isoniazid
dnaA 877 c.877T>C synonymous_variant 0.31 isoniazid
dnaA 885 c.885T>C synonymous_variant 0.38 isoniazid
dnaA 897 c.897A>G synonymous_variant 0.48 isoniazid
dnaA 903 c.903C>G synonymous_variant 0.48 isoniazid Not assoc w R - Interim
dnaA 909 c.909A>C synonymous_variant 0.48 isoniazid Not assoc w R - Interim
dnaA 912 c.912T>C synonymous_variant 0.48 isoniazid
dnaA 918 c.918C>G synonymous_variant 0.47 isoniazid
dnaA 921 c.921A>G synonymous_variant 0.46 isoniazid Not assoc w R - Interim
dnaA 927 c.927G>A synonymous_variant 0.46 isoniazid
dnaA 933 c.933C>G synonymous_variant 0.46 isoniazid
dnaA 948 p.Asp316Glu missense_variant 0.4 isoniazid
dnaA 955 c.955_957delAGAinsCGC synonymous_variant 0.33 isoniazid
dnaA 963 c.963C>A synonymous_variant 0.35 isoniazid
dnaA 966 c.966T>C synonymous_variant 0.33 isoniazid
dnaA 975 c.975G>T synonymous_variant 0.33 isoniazid
dnaA 984 c.984T>C synonymous_variant 0.3 isoniazid Not assoc w R - Interim
dnaA 990 c.990A>T synonymous_variant 0.3 isoniazid
dnaA 993 c.993A>G synonymous_variant 0.31 isoniazid
dnaA 996 c.996A>G synonymous_variant 0.34 isoniazid
dnaA 999 c.999C>G synonymous_variant 0.34 isoniazid
dnaA 1020 c.1020C>G synonymous_variant 0.35 isoniazid
dnaA 1024 c.1024T>C synonymous_variant 0.33 isoniazid
gyrA 7362 p.Glu21Gln missense_variant 0.93 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7430 c.129G>A synonymous_variant 0.38 levofloxacin
moxifloxacin
gyrA 7436 c.135C>T synonymous_variant 0.41 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7442 c.141G>C synonymous_variant 0.43 levofloxacin
moxifloxacin
gyrA 7451 c.150C>G synonymous_variant 0.48 levofloxacin
moxifloxacin
gyrA 7457 c.156T>C synonymous_variant 0.5 levofloxacin
moxifloxacin
gyrA 7472 c.171T>C synonymous_variant 0.53 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7475 c.174A>G synonymous_variant 0.53 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7484 c.183T>C synonymous_variant 0.51 levofloxacin
moxifloxacin
gyrA 7490 c.189C>G synonymous_variant 0.46 levofloxacin
moxifloxacin
gyrA 7499 c.198G>C synonymous_variant 0.49 levofloxacin
moxifloxacin
gyrA 7508 c.207C>T synonymous_variant 0.49 levofloxacin
moxifloxacin
gyrA 7523 c.222C>G synonymous_variant 0.5 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7532 c.231T>C synonymous_variant 0.49 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7535 c.234C>G synonymous_variant 0.49 levofloxacin
moxifloxacin
gyrA 7547 c.246C>T synonymous_variant 0.44 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7569 p.Ala90Ser missense_variant 0.4 levofloxacin
moxifloxacin
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7763 c.462T>C synonymous_variant 0.33 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7781 c.480G>A synonymous_variant 0.41 levofloxacin
moxifloxacin
gyrA 7784 c.483A>G synonymous_variant 0.42 levofloxacin
moxifloxacin
gyrA 7787 c.486G>A synonymous_variant 0.42 levofloxacin
moxifloxacin
gyrA 7790 c.489G>C synonymous_variant 0.42 levofloxacin
moxifloxacin
gyrA 7793 c.492G>C synonymous_variant 0.38 levofloxacin
moxifloxacin
gyrA 7799 c.498A>G synonymous_variant 0.42 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7832 c.531G>T synonymous_variant 0.44 levofloxacin
moxifloxacin
gyrA 7835 c.534A>C synonymous_variant 0.46 levofloxacin
moxifloxacin
gyrA 7841 c.540C>T synonymous_variant 0.41 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7859 c.558A>C synonymous_variant 0.42 levofloxacin
moxifloxacin
gyrA 8619 c.1318T>C synonymous_variant 0.45 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8636 c.1335A>C synonymous_variant 0.43 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8642 c.1341A>G synonymous_variant 0.43 levofloxacin
moxifloxacin
gyrA 8660 c.1359C>T synonymous_variant 0.45 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8672 c.1371A>G synonymous_variant 0.43 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8678 c.1377G>A synonymous_variant 0.43 levofloxacin
moxifloxacin
gyrA 8693 c.1392T>C synonymous_variant 0.41 levofloxacin
moxifloxacin
gyrA 8696 c.1395G>C synonymous_variant 0.41 levofloxacin
moxifloxacin
gyrA 8699 c.1398A>G synonymous_variant 0.41 levofloxacin
moxifloxacin
gyrA 9089 c.1788G>C synonymous_variant 0.5 levofloxacin
moxifloxacin
gyrA 9092 c.1791C>G synonymous_variant 0.47 levofloxacin
moxifloxacin
gyrA 9099 c.1798_1800delTTAinsCTG synonymous_variant 0.47 levofloxacin
moxifloxacin
gyrA 9104 c.1803C>G synonymous_variant 0.48 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9119 c.1818A>G synonymous_variant 0.38 levofloxacin
moxifloxacin
gyrA 9236 c.1935G>C synonymous_variant 0.53 levofloxacin
moxifloxacin
gyrA 9242 c.1941A>C synonymous_variant 0.6 levofloxacin
moxifloxacin
gyrA 9252 p.Val651Ile missense_variant 0.62 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9266 p.Asp655Glu missense_variant 0.73 levofloxacin
moxifloxacin
gyrA 9267 p.Asn656Gly missense_variant 0.73 levofloxacin
moxifloxacin
gyrA 9275 c.1974G>A synonymous_variant 0.78 levofloxacin
moxifloxacin
gyrA 9284 c.1983T>G synonymous_variant 0.75 levofloxacin
moxifloxacin
gyrA 9296 c.1995T>C synonymous_variant 0.69 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9304 p.Gly668Glu missense_variant 1.0 levofloxacin
moxifloxacin
gyrA 9335 c.2034G>C synonymous_variant 0.62 levofloxacin
moxifloxacin
gyrA 9341 c.2040C>G synonymous_variant 0.62 levofloxacin
moxifloxacin
gyrA 9345 c.2044A>C synonymous_variant 0.59 levofloxacin
moxifloxacin
gyrA 9356 c.2055G>C synonymous_variant 0.56 levofloxacin
moxifloxacin
gyrA 9377 c.2076A>G synonymous_variant 0.55 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9383 c.2082T>C synonymous_variant 0.5 levofloxacin
moxifloxacin
gyrA 9386 c.2085T>G synonymous_variant 0.46 levofloxacin
moxifloxacin
gyrA 9395 c.2094G>C synonymous_variant 0.38 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9398 c.2097T>C synonymous_variant 0.38 levofloxacin
moxifloxacin
fgd1 491742 c.960T>C synonymous_variant 1.0 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R
mshA 575627 p.Ala94Ser missense_variant 0.38 isoniazid
ethionamide
mshA 575635 c.288A>G synonymous_variant 0.37 isoniazid
ethionamide
mshA 575641 c.294A>G synonymous_variant 0.36 isoniazid
ethionamide
mshA 575652 p.Arg102Pro missense_variant 0.36 isoniazid
ethionamide
mshA 575656 c.309G>C synonymous_variant 0.33 isoniazid
ethionamide
mshA 575659 c.312A>G synonymous_variant 0.33 isoniazid
ethionamide
mshA 575689 c.342G>C synonymous_variant 0.29 isoniazid
ethionamide
mshA 575692 c.345G>C synonymous_variant 0.29 isoniazid
ethionamide
mshA 575695 c.348C>G synonymous_variant 0.31 isoniazid Not assoc w R - Interim
ethionamide
mshA 575704 c.357T>G synonymous_variant 0.27 isoniazid
ethionamide
mshA 575705 c.358_360delTTGinsCTC synonymous_variant 0.25 isoniazid
ethionamide
mshA 575708 p.Asp121Asn missense_variant 0.25 isoniazid
ethionamide
mshA 575713 c.366G>A synonymous_variant 0.27 isoniazid
ethionamide
ccsA 620670 c.780C>G synonymous_variant 0.44 kanamycin
capreomycin
amikacin
ccsA 620694 c.804C>G synonymous_variant 0.55 kanamycin
capreomycin
amikacin
ccsA 620698 p.Val270Ile missense_variant 0.53 kanamycin
capreomycin
amikacin
ccsA 620712 c.822G>C synonymous_variant 0.55 kanamycin
capreomycin
amikacin
ccsA 620718 c.828G>C synonymous_variant 0.5 kanamycin
capreomycin
amikacin
ccsA 620721 c.831G>C synonymous_variant 0.49 kanamycin
capreomycin
amikacin
ccsA 620733 c.843G>C synonymous_variant 0.53 kanamycin
capreomycin
amikacin
ccsA 620739 c.849A>G synonymous_variant 0.5 kanamycin
capreomycin
amikacin
ccsA 620745 c.855G>C synonymous_variant 0.5 kanamycin
capreomycin
amikacin
ccsA 620760 c.870C>G synonymous_variant 0.49 kanamycin
capreomycin
amikacin
ccsA 620761 p.Lys291Arg missense_variant 0.49 kanamycin
capreomycin
amikacin
ccsA 620778 c.888T>C synonymous_variant 0.55 kanamycin
capreomycin
amikacin
ccsA 620783 p.Ala298Val missense_variant 0.56 kanamycin
capreomycin
amikacin
ccsA 620793 c.903G>C synonymous_variant 0.58 kanamycin
capreomycin
amikacin
ccsA 620796 c.906C>G synonymous_variant 0.55 kanamycin
capreomycin
amikacin
ccsA 620802 c.912C>G synonymous_variant 0.56 kanamycin
capreomycin
amikacin
ccsA 620808 c.918T>C synonymous_variant 0.48 kanamycin Not assoc w R - Interim
capreomycin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv0565c 657081 c.390G>A synonymous_variant 1.0 ethionamide Not assoc w R - Interim
nusG 734502 c.249G>A synonymous_variant 0.74 rifampicin
nusG 734532 c.279A>G synonymous_variant 0.7 rifampicin Not assoc w R - Interim
nusG 734538 c.285C>G synonymous_variant 0.71 rifampicin
nusG 734541 c.288A>G synonymous_variant 0.71 rifampicin Not assoc w R - Interim
nusG 734559 c.306T>C synonymous_variant 0.76 rifampicin
nusG 734580 c.327T>C synonymous_variant 0.79 rifampicin Not assoc w R - Interim
nusG 734596 c.343T>C synonymous_variant 0.77 rifampicin
nusG 734616 c.363C>G synonymous_variant 0.72 rifampicin
nusG 734625 c.372T>C synonymous_variant 0.72 rifampicin
nusG 734631 c.378G>C synonymous_variant 0.7 rifampicin
nusG 734637 c.384G>T synonymous_variant 0.69 rifampicin
nusG 734643 c.390G>C synonymous_variant 0.64 rifampicin
nusG 734652 c.399T>C synonymous_variant 0.56 rifampicin
nusG 734655 c.402G>C synonymous_variant 0.59 rifampicin Not assoc w R - Interim
nusG 734658 c.405A>C synonymous_variant 0.59 rifampicin
nusG 734661 c.408A>C synonymous_variant 0.55 rifampicin
nusG 734664 c.411T>C synonymous_variant 0.58 rifampicin
nusG 734667 c.414C>G synonymous_variant 0.57 rifampicin
nusG 734673 c.420A>G synonymous_variant 0.57 rifampicin
nusG 734680 p.Ala143Ser missense_variant 0.55 rifampicin
nusG 734781 c.528A>G synonymous_variant 0.33 rifampicin
nusG 734786 p.Arg178Gln missense_variant 0.33 rifampicin
nusG 734794 p.Val181Ile missense_variant 0.36 rifampicin Uncertain significance
nusG 734814 c.561G>C synonymous_variant 0.39 rifampicin
nusG 734820 c.567A>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
nusG 734826 c.573A>G synonymous_variant 0.41 rifampicin
nusG 734847 c.594T>C synonymous_variant 0.43 rifampicin
nusG 734850 c.597C>G synonymous_variant 0.43 rifampicin
nusG 734853 c.600A>C synonymous_variant 0.45 rifampicin
nusG 734854 c.601T>C synonymous_variant 0.45 rifampicin
nusG 734865 c.612G>C synonymous_variant 0.45 rifampicin
nusG 734886 c.633A>G synonymous_variant 0.44 rifampicin
nusG 734910 c.657C>G synonymous_variant 0.4 rifampicin
nusG 734913 c.660C>G synonymous_variant 0.4 rifampicin
rpoB 759746 c.-61C>T upstream_gene_variant 1.0 rifampicin Not assoc w R
rpoB 762008 c.2202C>G synonymous_variant 0.55 rifampicin
rpoB 762014 c.2208C>T synonymous_variant 0.56 rifampicin
rpoB 762017 c.2211A>G synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoB 762053 c.2247T>C synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoB 762062 c.2256T>C synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>C synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoB 762083 c.2277T>C synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoB 762086 c.2280G>T synonymous_variant 0.61 rifampicin
rpoB 762110 c.2304G>C synonymous_variant 0.67 rifampicin
rpoB 762140 c.2334G>C synonymous_variant 0.7 rifampicin
rpoB 762149 c.2343G>C synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoB 762167 c.2361T>C synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoB 762170 c.2364C>G synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoB 762176 c.2370T>C synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoB 762185 c.2379G>C synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoB 762218 c.2412T>G synonymous_variant 0.68 rifampicin
rpoB 762233 c.2427G>C synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoB 762254 c.2448T>C synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoB 762257 c.2451C>G synonymous_variant 0.52 rifampicin
rpoB 762338 c.2532T>C synonymous_variant 0.59 rifampicin
rpoB 762347 c.2541T>C synonymous_variant 0.59 rifampicin
rpoB 762362 p.Glu852Asp missense_variant 0.48 rifampicin
rpoB 762368 c.2562G>A synonymous_variant 0.48 rifampicin
rpoB 762369 c.2563T>C synonymous_variant 0.48 rifampicin
rpoC 762374 c.-996G>C upstream_gene_variant 0.52 rifampicin
rpoC 762380 c.-990T>C upstream_gene_variant 0.53 rifampicin
rpoC 762395 c.-975G>C upstream_gene_variant 0.55 rifampicin
rpoC 762398 c.-972T>G upstream_gene_variant 0.55 rifampicin
rpoC 762401 c.-969G>C upstream_gene_variant 0.56 rifampicin
rpoB 762404 c.2598T>C synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoC 762407 c.-963G>C upstream_gene_variant 0.62 rifampicin
rpoC 762410 c.-960T>C upstream_gene_variant 0.62 rifampicin
rpoB 762416 c.2610A>G synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoB 762434 c.2628T>G synonymous_variant 0.35 rifampicin Not assoc w R
rpoC 762443 c.-927G>C upstream_gene_variant 0.6 rifampicin
rpoC 762467 c.-903C>T upstream_gene_variant 0.61 rifampicin
rpoC 763933 c.564C>T synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoC 763945 c.576T>C synonymous_variant 0.64 rifampicin
rpoC 763951 c.582G>C synonymous_variant 0.66 rifampicin Not assoc w R - Interim
rpoC 763960 c.591T>G synonymous_variant 0.66 rifampicin Not assoc w R - Interim
rpoC 763972 c.603C>T synonymous_variant 0.78 rifampicin
rpoC 763991 p.Ile208Leu missense_variant 0.82 rifampicin
rpoC 763996 c.627T>C synonymous_variant 0.81 rifampicin
rpoC 764005 c.636G>C synonymous_variant 0.84 rifampicin Not assoc w R - Interim
rpoC 764011 c.642T>G synonymous_variant 0.84 rifampicin
rpoC 764024 c.655_657delTTGinsCTC synonymous_variant 0.81 rifampicin
rpoC 764032 p.Asp221Glu missense_variant 0.83 rifampicin
rpoC 764040 p.Ser224Thr missense_variant 0.84 rifampicin
rpoC 764044 c.675T>C synonymous_variant 0.85 rifampicin
rpoC 764083 c.714A>G synonymous_variant 0.82 rifampicin
rpoC 764098 c.729A>G synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoC 764102 p.Val245Ile missense_variant 0.83 rifampicin
rpoC 764131 c.762T>G synonymous_variant 0.8 rifampicin
rpoC 764134 c.765C>G synonymous_variant 0.81 rifampicin Not assoc w R - Interim
rpoC 764140 c.771C>T synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoC 764143 c.774G>C synonymous_variant 0.78 rifampicin Not assoc w R - Interim
rpoC 764147 p.Ser260Ala missense_variant 0.78 rifampicin Uncertain significance
rpoC 764188 c.819A>G synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoC 764194 p.Glu275Asp missense_variant 0.79 rifampicin
rpoC 764203 c.834G>C synonymous_variant 0.72 rifampicin
rpoC 764206 c.837T>C synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoC 764207 p.Val280Ile missense_variant 0.7 rifampicin
rpoC 764213 p.Arg282Lys missense_variant 0.71 rifampicin Uncertain significance
rpoC 764266 c.897T>C synonymous_variant 0.65 rifampicin
rpoC 764278 c.909A>G synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoC 764317 c.948C>G synonymous_variant 0.59 rifampicin
rpoC 764713 c.1344G>A synonymous_variant 0.35 rifampicin
rpoC 764716 c.1347G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 765454 c.2085C>G synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoC 765466 c.2097C>T synonymous_variant 0.59 rifampicin
rpoC 765478 c.2109T>C synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoC 765493 c.2124G>C synonymous_variant 0.68 rifampicin
rpoC 765505 c.2136C>T synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoC 765550 c.2181C>T synonymous_variant 0.71 rifampicin
rpoC 765553 c.2184C>G synonymous_variant 0.73 rifampicin
rpoC 765556 c.2187G>C synonymous_variant 0.7 rifampicin
rpoC 765562 c.2193G>C synonymous_variant 0.66 rifampicin
rpoC 765565 c.2196G>C synonymous_variant 0.66 rifampicin
rpoC 765611 p.His748Ala missense_variant 0.64 rifampicin
rpoC 765621 p.Glu751Ala missense_variant 0.7 rifampicin
rpoC 765625 c.2256C>G synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoC 765637 c.2268C>G synonymous_variant 0.7 rifampicin
rpoC 765640 c.2271A>G synonymous_variant 0.7 rifampicin
rpoC 765655 c.2286T>C synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoC 765658 c.2289C>G synonymous_variant 0.62 rifampicin
rpoC 765661 c.2292T>G synonymous_variant 0.6 rifampicin
rpoC 765662 c.2293_2295delTTGinsCTC synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoC 765669 p.His767Arg missense_variant 0.6 rifampicin
rpoC 765673 p.Asp768Glu missense_variant 0.62 rifampicin
rpoC 765676 c.2307G>A synonymous_variant 0.6 rifampicin
rpoC 765681 p.Asn771Thr missense_variant 0.6 rifampicin
rpoC 765700 c.2331T>C synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoC 765728 p.Gln787Glu missense_variant 0.73 rifampicin
rpoC 765734 c.2365T>C synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoC 765739 c.2370G>C synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoC 765742 p.Glu791Asp missense_variant 0.71 rifampicin Uncertain significance
rpoC 765751 c.2382C>G synonymous_variant 0.72 rifampicin
rpoC 765753 p.Asp795Ala missense_variant 0.74 rifampicin Uncertain significance
rpoC 765772 c.2403C>G synonymous_variant 0.65 rifampicin
rpoC 765778 c.2409C>G synonymous_variant 0.62 rifampicin
rpoC 765781 p.Asp804Glu missense_variant 0.65 rifampicin
rpoC 765796 c.2427C>T synonymous_variant 0.63 rifampicin
rpoC 765811 c.2442T>C synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoC 765814 c.2445A>C synonymous_variant 0.67 rifampicin
rpoC 765817 c.2448G>C synonymous_variant 0.67 rifampicin
rpoC 765823 c.2454C>G synonymous_variant 0.59 rifampicin
rpoC 765826 c.2457T>G synonymous_variant 0.62 rifampicin
rpoC 765850 c.2481G>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoC 765979 c.2610C>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 765994 c.2625A>T synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 766003 c.2634G>C synonymous_variant 0.48 rifampicin
rpoC 766009 c.2640G>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 766021 c.2652G>C synonymous_variant 0.41 rifampicin
rpoC 766027 c.2658G>C synonymous_variant 0.39 rifampicin
rpoC 766043 p.Gln892Gly missense_variant 0.33 rifampicin
rpoC 766054 c.2685C>G synonymous_variant 0.35 rifampicin
rpoC 766061 p.Val898Thr missense_variant 0.31 rifampicin
rpoC 766066 c.2697C>G synonymous_variant 0.32 rifampicin
rpoC 766082 p.Ala905Gln missense_variant 0.32 rifampicin
rpoC 766096 c.2727G>C synonymous_variant 0.32 rifampicin
rpoC 766280 p.Ser971Gly missense_variant 0.39 rifampicin
rpoC 766288 c.2919C>G synonymous_variant 0.41 rifampicin
rpoC 766298 p.Thr977Leu missense_variant 0.47 rifampicin
rpoC 766312 c.2943T>G synonymous_variant 0.56 rifampicin
rpoC 766315 c.2946C>G synonymous_variant 0.58 rifampicin
rpoC 766321 c.2952C>G synonymous_variant 0.58 rifampicin
rpoC 766348 c.2979A>G synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoC 766363 c.2994G>C synonymous_variant 0.71 rifampicin
rpoC 766381 c.3012C>T synonymous_variant 0.71 rifampicin
rpoC 766384 c.3015A>G synonymous_variant 0.71 rifampicin
rpoC 766390 c.3021C>T synonymous_variant 0.73 rifampicin
rpoC 766426 c.3057C>T synonymous_variant 0.74 rifampicin
rpoC 766456 c.3087C>G synonymous_variant 0.7 rifampicin
rpoC 766480 c.3111C>G synonymous_variant 0.67 rifampicin
rpoC 766486 c.3117A>G synonymous_variant 0.67 rifampicin
rpoC 766492 c.3123T>C synonymous_variant 0.69 rifampicin
rpoC 766495 c.3126C>T synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoC 766516 c.3147C>G synonymous_variant 0.64 rifampicin
rpoC 766517 p.Thr1050Ser missense_variant 0.67 rifampicin
rpoC 766526 p.Val1053Ile missense_variant 0.65 rifampicin
rpoC 766534 c.3165C>G synonymous_variant 0.63 rifampicin
rpoC 766540 p.Asp1057Glu missense_variant 0.59 rifampicin
rpoC 766542 p.Gly1058Asp missense_variant 0.61 rifampicin
rpoC 766568 p.Val1067Ile missense_variant 0.66 rifampicin
rpoC 766573 c.3204T>C synonymous_variant 0.68 rifampicin
rpoC 766585 c.3216T>G synonymous_variant 0.7 rifampicin
rpoC 766591 c.3222A>G synonymous_variant 0.69 rifampicin
rpoC 766592 p.Val1075Leu missense_variant 0.69 rifampicin
rpoC 766607 p.Ile1080Leu missense_variant 0.71 rifampicin
rpoC 766618 c.3249G>T synonymous_variant 0.7 rifampicin
rpoC 766628 p.Arg1087Lys missense_variant 0.72 rifampicin
rpoC 766644 p.Glu1092Ala missense_variant 0.68 rifampicin
rpoC 766652 p.Ser1095Glu missense_variant 0.65 rifampicin
rpoC 766657 c.3288A>G synonymous_variant 0.67 rifampicin
rpoC 766661 p.Val1098Leu missense_variant 0.67 rifampicin
rpoC 766666 c.3297C>G synonymous_variant 0.67 rifampicin
rpoC 766667 p.Ser1100Ala missense_variant 0.67 rifampicin Uncertain significance
rpoC 766672 c.3303T>C synonymous_variant 0.69 rifampicin
rpoC 766700 c.3331C>T synonymous_variant 0.74 rifampicin
rpoC 766703 p.Met1112Leu missense_variant 0.75 rifampicin
rpoC 766708 c.3339A>G synonymous_variant 0.74 rifampicin
rpoC 766714 c.3345G>C synonymous_variant 0.68 rifampicin
rpoC 766726 c.3357T>C synonymous_variant 0.67 rifampicin
rpoC 766738 c.3369G>C synonymous_variant 0.68 rifampicin
rpoC 766750 c.3381C>G synonymous_variant 0.68 rifampicin
rpoC 766753 c.3384C>T synonymous_variant 0.68 rifampicin
rpoC 766765 c.3396A>C synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoC 766774 p.Arg1136Asn missense_variant 0.59 rifampicin
rpoC 766777 c.3408C>G synonymous_variant 0.59 rifampicin
rpoC 766804 c.3435A>G synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoC 766843 c.3474T>C synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoC 766846 c.3477C>G synonymous_variant 0.66 rifampicin Not assoc w R - Interim
rpoC 766879 c.3510G>C synonymous_variant 0.69 rifampicin
rpoC 766882 c.3513C>G synonymous_variant 0.72 rifampicin
rpoC 766885 c.3516G>C synonymous_variant 0.74 rifampicin
rpoC 766894 c.3525T>C synonymous_variant 0.74 rifampicin
rpoC 766895 c.3526T>C synonymous_variant 0.77 rifampicin
rpoC 766900 c.3531T>C synonymous_variant 0.77 rifampicin
rpoC 766909 c.3540G>C synonymous_variant 0.83 rifampicin
rpoC 766911 p.Ile1181Thr missense_variant 0.83 rifampicin
rpoC 766915 p.Asp1182Glu missense_variant 0.81 rifampicin
rpoC 766921 c.3552G>C synonymous_variant 0.81 rifampicin
rpoC 766931 p.Ala1188Ser missense_variant 0.78 rifampicin Uncertain significance
rpoC 766942 c.3573C>G synonymous_variant 0.77 rifampicin
rpoC 766945 c.3576A>G synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoC 766949 p.Val1194Met missense_variant 0.77 rifampicin
rpoC 766963 c.3594T>C synonymous_variant 0.79 rifampicin Not assoc w R - Interim
rpoC 766972 c.3603G>C synonymous_variant 0.72 rifampicin
rpoC 766975 c.3606C>G synonymous_variant 0.72 rifampicin
rpoC 766996 c.3627C>G synonymous_variant 0.67 rifampicin
rpoC 767002 c.3633G>C synonymous_variant 0.67 rifampicin Not assoc w R - Interim
mmpL5 775639 p.Ile948Val missense_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
mmpL5 775851 p.Ser877Thr missense_variant 0.28 bedaquiline
clofazimine
mmpL5 775856 c.2625T>C synonymous_variant 0.26 bedaquiline
clofazimine
mmpL5 775865 c.2616T>C synonymous_variant 0.3 bedaquiline
clofazimine
mmpL5 775881 p.Asn867Arg missense_variant 0.3 bedaquiline
clofazimine
mmpL5 775883 p.Ile866Leu missense_variant 0.32 bedaquiline
clofazimine
mmpL5 775886 c.2595A>C synonymous_variant 0.32 bedaquiline
clofazimine
mmpL5 775909 p.Leu858Phe missense_variant 0.4 bedaquiline
clofazimine
mmpL5 775913 p.Ala856Ser missense_variant 0.35 bedaquiline
clofazimine
mmpL5 775916 c.2565T>G synonymous_variant 0.39 bedaquiline
clofazimine
mmpL5 775922 c.2559G>A synonymous_variant 0.35 bedaquiline
clofazimine
mmpL5 775937 p.Ala848Ser missense_variant 0.5 bedaquiline
clofazimine
mmpL5 775940 c.2541C>G synonymous_variant 0.43 bedaquiline
clofazimine
mmpL5 775946 c.2535C>G synonymous_variant 0.46 bedaquiline
clofazimine
mmpL5 776100 p.Thr794Ile missense_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rplC 800543 c.-266C>T upstream_gene_variant 0.42 linezolid
rplC 800567 c.-242A>G upstream_gene_variant 0.4 linezolid
rplC 800570 c.-239C>G upstream_gene_variant 0.4 linezolid
rplC 800574 c.-235_-234delGTinsAC upstream_gene_variant 0.38 linezolid
rplC 800579 c.-230C>T upstream_gene_variant 0.33 linezolid
rplC 800582 c.-227C>G upstream_gene_variant 0.38 linezolid
rplC 800585 c.-224T>A upstream_gene_variant 0.38 linezolid
rplC 800590 c.-219_-218delGCinsAT upstream_gene_variant 0.4 linezolid
rplC 800594 c.-215C>G upstream_gene_variant 0.4 linezolid
rplC 800597 c.-212A>T upstream_gene_variant 0.42 linezolid
rplC 800600 c.-209G>C upstream_gene_variant 0.42 linezolid
rplC 800612 c.-197A>G upstream_gene_variant 0.42 linezolid
rplC 800618 c.-191T>C upstream_gene_variant 0.5 linezolid
rplC 800628 c.-181_-179delGTGinsATC upstream_gene_variant 0.56 linezolid
rplC 800633 c.-176T>C upstream_gene_variant 0.56 linezolid
rplC 800648 c.-161A>C upstream_gene_variant 0.5 linezolid
rplC 800654 c.-155T>C upstream_gene_variant 0.5 linezolid
rplC 801156 c.348T>C synonymous_variant 0.5 linezolid
rplC 801171 c.363A>G synonymous_variant 0.48 linezolid
rplC 801184 p.Thr126Val missense_variant 0.48 linezolid
rplC 801205 p.Arg133Ala missense_variant 0.48 linezolid
rplC 801210 c.402T>C synonymous_variant 0.5 linezolid
rplC 801222 c.414T>C synonymous_variant 0.5 linezolid
rplC 801228 c.420T>C synonymous_variant 0.47 linezolid
rplC 801229 p.Ala141Thr missense_variant 0.44 linezolid
rplC 801249 c.441T>C synonymous_variant 0.44 linezolid
rplC 801252 c.444G>C synonymous_variant 0.43 linezolid
rplC 801258 c.450C>G synonymous_variant 0.41 linezolid
rplC 801288 c.480G>C synonymous_variant 0.38 linezolid
Rv1129c 1254562 c.-28T>C upstream_gene_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
isoniazid Not assoc w R
rifampicin Not assoc w R
fbiC 1303272 c.342A>G synonymous_variant 0.42 pretomanid
delamanid
clofazimine
fbiC 1303281 c.351A>G synonymous_variant 0.4 pretomanid
delamanid
clofazimine
fbiC 1303283 c.354_356delTTC disruptive_inframe_deletion 0.43 pretomanid
delamanid
clofazimine
fbiC 1303288 c.358_359insAGG disruptive_inframe_insertion 0.42 pretomanid
delamanid
clofazimine
fbiC 1303292 p.Thr121Met missense_variant 0.42 pretomanid
delamanid
clofazimine
fbiC 1303296 c.366T>C synonymous_variant 0.43 pretomanid
delamanid
clofazimine
fbiC 1303302 c.372A>G synonymous_variant 0.43 pretomanid
delamanid
clofazimine
fbiC 1303323 c.393T>C synonymous_variant 0.43 pretomanid
delamanid
clofazimine
fbiC 1303326 c.396C>G synonymous_variant 0.38 pretomanid
delamanid
clofazimine
fbiC 1303332 c.402A>C synonymous_variant 0.36 pretomanid
delamanid
clofazimine
sigE 1364950 p.Ala180Ser missense_variant 0.33 pyrazinamide
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 kanamycin
capreomycin
streptomycin
amikacin
rrl 1475355 n.1698C>T non_coding_transcript_exon_variant 0.62 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475369 n.1712G>C non_coding_transcript_exon_variant 0.47 capreomycin
linezolid
rrl 1475375 n.1718G>A non_coding_transcript_exon_variant 0.47 capreomycin Uncertain significance
linezolid
rrl 1475378 n.1723_1724delCG non_coding_transcript_exon_variant 0.47 capreomycin
linezolid
rrl 1475383 n.1726_1727insCC non_coding_transcript_exon_variant 0.47 capreomycin
linezolid
rrl 1475395 n.1738T>G non_coding_transcript_exon_variant 0.47 capreomycin
linezolid
rrl 1475396 n.1739C>G non_coding_transcript_exon_variant 0.47 capreomycin
linezolid
rrl 1475397 n.1740G>T non_coding_transcript_exon_variant 0.47 capreomycin
linezolid
rrl 1475403 n.1746T>A non_coding_transcript_exon_variant 0.5 capreomycin
linezolid
rrl 1475404 n.1747A>T non_coding_transcript_exon_variant 0.5 capreomycin
linezolid
rrl 1475407 n.1750C>T non_coding_transcript_exon_variant 0.5 capreomycin
linezolid
rrl 1475409 n.1752T>C non_coding_transcript_exon_variant 0.47 capreomycin
linezolid
rrl 1475419 n.1762C>T non_coding_transcript_exon_variant 0.53 capreomycin Uncertain significance
linezolid
rrl 1475429 n.1772G>T non_coding_transcript_exon_variant 0.53 capreomycin Uncertain significance
linezolid
rrl 1475430 n.1773T>A non_coding_transcript_exon_variant 0.53 capreomycin
linezolid
rrl 1475460 n.1803A>G non_coding_transcript_exon_variant 0.52 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475480 n.1823A>T non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid Uncertain significance
inhA 1674507 c.306G>C synonymous_variant 0.44 isoniazid
ethionamide
inhA 1674513 c.312C>A synonymous_variant 0.5 isoniazid
ethionamide
inhA 1674514 p.Ile105Val missense_variant 0.5 isoniazid
ethionamide
inhA 1674534 c.333G>C synonymous_variant 0.65 isoniazid Not assoc w R - Interim
ethionamide
inhA 1674542 p.Ala114Glu missense_variant 0.59 isoniazid
ethionamide
inhA 1674546 c.345T>C synonymous_variant 0.59 isoniazid
ethionamide
inhA 1674549 c.348G>C synonymous_variant 0.59 isoniazid
ethionamide
inhA 1674550 p.Ser117Ala missense_variant 0.64 isoniazid
ethionamide
inhA 1674570 c.369G>C synonymous_variant 0.73 isoniazid
ethionamide
inhA 1674573 c.372G>C synonymous_variant 0.73 isoniazid
ethionamide
inhA 1674576 c.375T>C synonymous_variant 0.75 isoniazid
ethionamide
inhA 1674585 c.384T>C synonymous_variant 0.78 isoniazid
ethionamide
inhA 1674589 p.Met130Leu missense_variant 0.78 isoniazid
ethionamide
inhA 1674601 p.Leu134Val missense_variant 0.83 isoniazid
ethionamide
inhA 1674624 c.423A>C synonymous_variant 0.84 isoniazid
ethionamide
inhA 1674627 c.426T>C synonymous_variant 0.84 isoniazid
ethionamide
inhA 1674628 p.Ser143Gly missense_variant 0.82 isoniazid
ethionamide
inhA 1674656 p.Ser152Thr missense_variant 0.83 isoniazid
ethionamide
inhA 1674660 c.459G>C synonymous_variant 0.83 isoniazid
ethionamide
inhA 1674669 c.468G>C synonymous_variant 0.82 isoniazid
ethionamide
inhA 1674693 c.492C>G synonymous_variant 0.78 isoniazid
ethionamide
inhA 1674702 c.501G>A synonymous_variant 0.77 isoniazid
ethionamide
inhA 1674703 c.502T>C synonymous_variant 0.76 isoniazid
ethionamide
inhA 1674714 c.513C>G synonymous_variant 0.76 isoniazid
ethionamide
inhA 1674718 c.517A>C synonymous_variant 0.7 isoniazid
ethionamide
inhA 1674729 c.528G>C synonymous_variant 0.63 isoniazid
ethionamide
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
katG 2154724 p.Arg463Leu missense_variant 1.0 isoniazid Not assoc w R
PPE35 2167926 p.Leu896Ser missense_variant 1.0 pyrazinamide Not assoc w R
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
pncA 2289047 c.195C>T synonymous_variant 1.0 pyrazinamide Not assoc w R
pncA 2289365 c.-125delC upstream_gene_variant 1.0 pyrazinamide
ahpC 2726105 c.-88G>A upstream_gene_variant 1.0 isoniazid Not assoc w R
Rv2477c 2782969 c.1074A>C synonymous_variant 0.35 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782972 c.1071G>C synonymous_variant 0.38 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782984 c.1059T>C synonymous_variant 0.37 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782987 c.1056C>G synonymous_variant 0.42 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782990 c.1053C>G synonymous_variant 0.48 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783002 c.1041T>C synonymous_variant 0.45 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783008 c.1035C>G synonymous_variant 0.48 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783013 c.1030T>C synonymous_variant 0.48 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783015 p.Ser343Thr missense_variant 0.48 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783020 c.1023G>C synonymous_variant 0.45 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783040 p.Ala335Thr missense_variant 0.41 kanamycin Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
rifampicin Uncertain significance
ethambutol Uncertain significance
amikacin Uncertain significance
Rv2477c 2783047 p.Asp332Gly missense_variant 0.33 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783051 p.Tyr331Phe missense_variant 0.32 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783053 c.990C>T synonymous_variant 0.32 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783059 c.984T>C synonymous_variant 0.32 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783065 c.978C>T synonymous_variant 0.35 kanamycin
levofloxacin
moxifloxacin
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin
Rv2477c 2783068 p.Asp325Glu missense_variant 0.36 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783077 c.966T>C synonymous_variant 0.38 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783083 c.960G>C synonymous_variant 0.38 kanamycin
levofloxacin
moxifloxacin
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin
Rv2477c 2783299 c.744A>G synonymous_variant 0.65 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783302 c.741A>G synonymous_variant 0.65 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783311 c.732T>C synonymous_variant 0.62 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783317 c.726G>C synonymous_variant 0.64 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783332 c.711T>C synonymous_variant 0.68 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783344 c.699C>G synonymous_variant 0.7 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783350 c.693T>C synonymous_variant 0.7 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783353 c.690T>C synonymous_variant 0.68 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783359 c.684G>A synonymous_variant 0.69 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783371 c.672A>G synonymous_variant 0.69 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783374 c.669G>C synonymous_variant 0.69 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783395 c.648T>C synonymous_variant 0.74 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783410 c.633G>C synonymous_variant 0.76 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783422 c.621T>G synonymous_variant 0.8 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783427 p.Pro206Ala missense_variant 0.79 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin Uncertain significance
ethambutol Uncertain significance
amikacin
Rv2477c 2783432 p.Ser204Ala missense_variant 0.78 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783440 c.603T>C synonymous_variant 0.76 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783461 c.582T>C synonymous_variant 0.76 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783467 c.576G>C synonymous_variant 0.76 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783473 c.570A>C synonymous_variant 0.78 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783499 c.544T>C synonymous_variant 0.78 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783502 c.541T>C synonymous_variant 0.78 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783509 c.534C>G synonymous_variant 0.81 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783520 c.523T>C synonymous_variant 0.8 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin
Rv2477c 2783527 c.516A>G synonymous_variant 0.78 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783548 c.495T>G synonymous_variant 0.71 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783554 c.489C>G synonymous_variant 0.69 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783563 c.480A>C synonymous_variant 0.65 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783566 p.Asn159Gln missense_variant 0.65 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783572 c.471A>C synonymous_variant 0.62 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783586 p.Ala153Pro missense_variant 0.64 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783593 c.450T>C synonymous_variant 0.68 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783605 c.438T>C synonymous_variant 0.65 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783623 c.420G>A synonymous_variant 0.64 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2752c 3065888 p.Val102Ile missense_variant 0.32 levofloxacin
moxifloxacin
isoniazid Uncertain significance
rifampicin Uncertain significance
ethambutol Uncertain significance
Rv2752c 3065898 c.294C>G synonymous_variant 0.32 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065901 c.291A>C synonymous_variant 0.33 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065905 p.Leu96Gln missense_variant 0.35 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065907 c.285G>A synonymous_variant 0.35 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065916 c.276T>C synonymous_variant 0.39 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065922 c.270T>C synonymous_variant 0.48 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065946 p.Gly82Ala missense_variant 0.57 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065955 c.235_237delTTGinsCTC synonymous_variant 0.57 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065972 p.Ile74Val missense_variant 0.55 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065979 c.213T>C synonymous_variant 0.55 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065988 p.Glu68Ala missense_variant 0.5 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065993 p.Val67Ile missense_variant 0.5 levofloxacin
moxifloxacin
isoniazid Uncertain significance
rifampicin Uncertain significance
ethambutol Uncertain significance
Rv2752c 3065994 c.198T>C synonymous_variant 0.5 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066002 p.Met64Leu missense_variant 0.48 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066006 c.186G>C synonymous_variant 0.47 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066015 c.177G>C synonymous_variant 0.47 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066018 c.174T>C synonymous_variant 0.47 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066024 c.168T>C synonymous_variant 0.47 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
lpqB 3624339 p.Arg191Pro missense_variant 0.48 rifampicin
bedaquiline
lpqB 3624341 c.570C>T synonymous_variant 0.48 rifampicin
bedaquiline
lpqB 3624347 c.564G>C synonymous_variant 0.56 rifampicin
bedaquiline
lpqB 3624353 c.558C>G synonymous_variant 0.61 rifampicin
bedaquiline
lpqB 3624365 c.546T>C synonymous_variant 0.71 rifampicin
bedaquiline
lpqB 3624371 c.540T>G synonymous_variant 0.71 rifampicin
bedaquiline
lpqB 3624376 p.Val179Met missense_variant 0.71 rifampicin
bedaquiline
lpqB 3624382 p.Lys177Gln missense_variant 0.71 rifampicin
bedaquiline
lpqB 3624383 c.528C>G synonymous_variant 0.71 rifampicin
bedaquiline
lpqB 3624396 p.Ala172Val missense_variant 0.76 rifampicin
bedaquiline
lpqB 3624416 c.495G>A synonymous_variant 0.81 rifampicin
bedaquiline
lpqB 3624422 c.489G>C synonymous_variant 0.78 rifampicin
bedaquiline
lpqB 3624425 c.486A>G synonymous_variant 0.78 rifampicin
bedaquiline
lpqB 3624428 c.483A>G synonymous_variant 0.81 rifampicin
bedaquiline
lpqB 3624437 c.474G>A synonymous_variant 0.83 rifampicin
bedaquiline
lpqB 3624452 c.459T>C synonymous_variant 0.81 rifampicin
bedaquiline
lpqB 3624455 c.456G>C synonymous_variant 0.79 rifampicin
bedaquiline
lpqB 3624464 c.447A>G synonymous_variant 0.78 rifampicin
bedaquiline
lpqB 3624467 c.444C>G synonymous_variant 0.76 rifampicin
bedaquiline
lpqB 3624470 c.441T>C synonymous_variant 0.79 rifampicin
bedaquiline
lpqB 3624476 c.435C>G synonymous_variant 0.77 rifampicin
bedaquiline
lpqB 3624485 p.Asp142Glu missense_variant 0.75 rifampicin
bedaquiline
lpqB 3624490 p.Ser141Ala missense_variant 0.69 rifampicin
bedaquiline
lpqB 3624491 c.420G>C synonymous_variant 0.69 rifampicin
bedaquiline
mtrB 3625065 p.Met517Leu missense_variant 1.0 rifampicin Not assoc w R
bedaquiline Uncertain significance
mtrB 3625729 c.885A>G synonymous_variant 0.74 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625735 c.879C>A synonymous_variant 0.7 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625753 p.Ala287Glu missense_variant 0.65 rifampicin
bedaquiline
mtrB 3625762 c.852A>G synonymous_variant 0.65 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625774 c.840G>A synonymous_variant 0.68 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3625801 c.-891G>C upstream_gene_variant 0.75 rifampicin
bedaquiline
mtrB 3625806 c.808A>C synonymous_variant 0.77 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625837 c.777C>G synonymous_variant 0.81 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3625840 c.-930A>G upstream_gene_variant 0.79 rifampicin
bedaquiline
mtrB 3625849 p.His255Tyr missense_variant 0.76 rifampicin
bedaquiline
lpqB 3625852 c.-942A>C upstream_gene_variant 0.76 rifampicin
bedaquiline
lpqB 3625864 c.-954T>G upstream_gene_variant 0.76 rifampicin
bedaquiline
mtrB 3625874 p.Ile247Thr missense_variant 0.73 rifampicin
bedaquiline
mtrB 3625876 c.738G>C synonymous_variant 0.72 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625881 p.Ser245Ala missense_variant 0.72 rifampicin Uncertain significance
bedaquiline
mtrB 3625887 p.Ser243Ala missense_variant 0.74 rifampicin
bedaquiline
mtrB 3625899 p.Val239Leu missense_variant 0.74 rifampicin
bedaquiline
lpqB 3625909 c.-999T>G upstream_gene_variant 0.81 rifampicin
bedaquiline
mtrB 3625927 c.687T>C synonymous_variant 0.77 rifampicin
bedaquiline
mtrB 3625936 c.678C>G synonymous_variant 0.71 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625942 c.672C>G synonymous_variant 0.7 rifampicin
bedaquiline
mtrB 3625945 c.669A>G synonymous_variant 0.65 rifampicin
bedaquiline
rpoA 3877494 p.Glu338Asp missense_variant 0.33 rifampicin Uncertain significance
rpoA 3877503 p.Ala335Gly missense_variant 0.39 rifampicin
rpoA 3877509 p.Glu333Asp missense_variant 0.38 rifampicin
rpoA 3877515 p.Ser331Asn missense_variant 0.38 rifampicin
rpoA 3877528 p.Thr327Ser missense_variant 0.52 rifampicin
rpoA 3877533 c.975C>G synonymous_variant 0.54 rifampicin
rpoA 3877545 c.963G>C synonymous_variant 0.69 rifampicin
rpoA 3877554 c.954G>C synonymous_variant 0.7 rifampicin
rpoA 3877557 c.951C>G synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoA 3877569 p.Pro313Ala missense_variant 0.73 rifampicin
rpoA 3877587 p.Ser307Ala missense_variant 0.8 rifampicin
rpoA 3877613 p.Ile299Val missense_variant 0.81 rifampicin
rpoA 3877629 c.879C>G synonymous_variant 0.82 rifampicin
rpoA 3877638 c.870T>G synonymous_variant 0.82 rifampicin
rpoA 3877656 c.852T>C synonymous_variant 0.84 rifampicin Not assoc w R - Interim
rpoA 3877668 c.840A>G synonymous_variant 0.86 rifampicin
rpoA 3877680 c.828G>C synonymous_variant 0.84 rifampicin Not assoc w R - Interim
rpoA 3877686 c.822A>G synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoA 3877692 c.816G>C synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoA 3877704 c.804G>C synonymous_variant 0.8 rifampicin
rpoA 3877710 c.798C>G synonymous_variant 0.79 rifampicin
rpoA 3877731 c.777G>C synonymous_variant 0.77 rifampicin
rpoA 3877737 c.771G>C synonymous_variant 0.76 rifampicin
rpoA 3877743 c.765T>C synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoA 3877764 c.744C>G synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoA 3877770 c.738A>G synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoA 3877776 c.732T>C synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoA 3877782 c.726T>C synonymous_variant 0.66 rifampicin Not assoc w R - Interim
rpoA 3877788 c.720G>A synonymous_variant 0.65 rifampicin
rpoA 3878853 c.-346G>A upstream_gene_variant 0.44 rifampicin
clpC1 4038537 p.Thr723Ser missense_variant 0.5 pyrazinamide
clpC1 4038587 c.2118C>G synonymous_variant 0.48 pyrazinamide
clpC1 4038596 c.2109A>G synonymous_variant 0.5 pyrazinamide
clpC1 4038602 c.2103G>C synonymous_variant 0.5 pyrazinamide
clpC1 4038620 p.Gln695Leu missense_variant 0.46 pyrazinamide
clpC1 4038623 c.2082A>G synonymous_variant 0.44 pyrazinamide
clpC1 4038640 p.Asp689Asn missense_variant 0.46 pyrazinamide
clpC1 4038647 c.2058T>G synonymous_variant 0.46 pyrazinamide
clpC1 4038658 p.Lys683Gln missense_variant 0.45 pyrazinamide
clpC1 4038812 c.1893T>C synonymous_variant 0.44 pyrazinamide
clpC1 4038815 c.1890G>C synonymous_variant 0.43 pyrazinamide
clpC1 4038878 c.1827A>G synonymous_variant 0.65 pyrazinamide Not assoc w R - Interim
clpC1 4038905 c.1800A>C synonymous_variant 0.71 pyrazinamide
clpC1 4038908 c.1797C>G synonymous_variant 0.75 pyrazinamide
clpC1 4038914 c.1791G>C synonymous_variant 0.78 pyrazinamide
clpC1 4038923 c.1782A>G synonymous_variant 0.82 pyrazinamide
clpC1 4038932 c.1773G>C synonymous_variant 0.84 pyrazinamide
clpC1 4038953 c.1752A>G synonymous_variant 0.84 pyrazinamide
clpC1 4038956 c.1749T>C synonymous_variant 0.86 pyrazinamide
clpC1 4038965 c.1740T>C synonymous_variant 0.83 pyrazinamide
clpC1 4038971 c.1734T>C synonymous_variant 0.82 pyrazinamide
clpC1 4038974 c.1731T>G synonymous_variant 0.82 pyrazinamide
clpC1 4038989 c.1716T>C synonymous_variant 0.81 pyrazinamide
clpC1 4038997 c.1708T>C synonymous_variant 0.8 pyrazinamide Not assoc w R - Interim
clpC1 4039001 p.Asn568Glu missense_variant 0.8 pyrazinamide
clpC1 4039004 c.1701C>G synonymous_variant 0.78 pyrazinamide
clpC1 4039021 c.1684C>T synonymous_variant 0.75 pyrazinamide
clpC1 4039022 c.1683A>G synonymous_variant 0.75 pyrazinamide
clpC1 4039031 c.1674T>C synonymous_variant 0.72 pyrazinamide
clpC1 4039037 c.1668T>G synonymous_variant 0.67 pyrazinamide
clpC1 4039046 c.1659C>G synonymous_variant 0.61 pyrazinamide
clpC1 4039064 c.1641C>G synonymous_variant 0.52 pyrazinamide
clpC1 4039067 c.1638G>C synonymous_variant 0.48 pyrazinamide
clpC1 4039073 c.1632C>G synonymous_variant 0.46 pyrazinamide
clpC1 4039076 c.1629G>A synonymous_variant 0.52 pyrazinamide
clpC1 4039085 c.1620A>G synonymous_variant 0.54 pyrazinamide
clpC1 4039097 c.1608G>C synonymous_variant 0.55 pyrazinamide
clpC1 4039103 c.1602T>C synonymous_variant 0.57 pyrazinamide
clpC1 4039112 c.1593C>G synonymous_variant 0.61 pyrazinamide
clpC1 4039121 c.1584T>C synonymous_variant 0.6 pyrazinamide
clpC1 4039127 p.Lys526Asn missense_variant 0.61 pyrazinamide
clpC1 4039133 c.1572C>G synonymous_variant 0.63 pyrazinamide
clpC1 4039139 p.Glu522Asp missense_variant 0.67 pyrazinamide
clpC1 4039142 c.1563A>G synonymous_variant 0.69 pyrazinamide
clpC1 4039145 c.1560G>C synonymous_variant 0.7 pyrazinamide
clpC1 4039169 p.Glu512Asp missense_variant 0.71 pyrazinamide
clpC1 4039172 c.1533A>G synonymous_variant 0.72 pyrazinamide
clpC1 4039178 c.1527G>C synonymous_variant 0.69 pyrazinamide
clpC1 4039183 c.1522T>C synonymous_variant 0.69 pyrazinamide
clpC1 4039226 c.1479T>C synonymous_variant 0.72 pyrazinamide Not assoc w R - Interim
clpC1 4039247 c.1458G>A synonymous_variant 0.71 pyrazinamide
clpC1 4039274 c.1431G>C synonymous_variant 0.68 pyrazinamide Not assoc w R - Interim
clpC1 4039286 c.1419T>C synonymous_variant 0.61 pyrazinamide
clpC1 4039289 c.1416T>C synonymous_variant 0.63 pyrazinamide
clpC1 4039292 c.1413C>T synonymous_variant 0.61 pyrazinamide
clpC1 4039295 c.1410A>C synonymous_variant 0.61 pyrazinamide
clpC1 4039298 c.1407T>C synonymous_variant 0.59 pyrazinamide
clpC1 4039310 c.1395A>G synonymous_variant 0.53 pyrazinamide
clpC1 4039313 c.1392C>G synonymous_variant 0.53 pyrazinamide
clpC1 4039319 p.Ala462Thr missense_variant 0.53 pyrazinamide
clpC1 4039322 c.1383T>C synonymous_variant 0.52 pyrazinamide
clpC1 4039328 c.1377A>T synonymous_variant 0.52 pyrazinamide
clpC1 4039337 p.Thr456Gln missense_variant 0.53 pyrazinamide
clpC1 4039347 p.Arg453Gln missense_variant 0.61 pyrazinamide Uncertain significance
clpC1 4039382 c.1323C>G synonymous_variant 0.52 pyrazinamide
panD 4044872 c.-591C>T upstream_gene_variant 1.0 pyrazinamide
glpK 4138622 c.1134C>T synonymous_variant 0.52 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
isoniazid Not assoc w R
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R
ethambutol Not assoc w R
glpK 4138625 c.1131G>C synonymous_variant 0.5 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138628 c.1128T>C synonymous_variant 0.54 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138643 c.1113A>C synonymous_variant 0.57 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138655 c.1101G>C synonymous_variant 0.51 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138658 c.1098C>G synonymous_variant 0.53 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138661 c.1095T>C synonymous_variant 0.53 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138681 p.Met359Val missense_variant 0.61 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138682 c.1074C>G synonymous_variant 0.58 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138690 p.Asn356His missense_variant 0.55 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138696 p.Pro354Ala missense_variant 0.57 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138702 p.Gln352Glu missense_variant 0.55 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138703 c.1053C>G synonymous_variant 0.55 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138718 c.1038T>C synonymous_variant 0.57 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138724 c.1032A>G synonymous_variant 0.55 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138742 c.1014C>G synonymous_variant 0.54 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138747 c.1009C>T synonymous_variant 0.54 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138751 c.1005T>C synonymous_variant 0.56 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138757 c.999A>G synonymous_variant 0.54 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138775 c.981C>G synonymous_variant 0.44 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139575 p.Val61Phe missense_variant 0.77 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139627 c.129G>A synonymous_variant 0.77 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
streptomycin
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
glpK 4139633 c.123C>T synonymous_variant 0.77 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139637 p.Ala40Gly missense_variant 0.71 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139647 p.Ala37Thr missense_variant 0.71 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139648 c.108T>C synonymous_variant 0.71 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139652 p.His35Thr missense_variant 0.71 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139657 c.99T>C synonymous_variant 0.71 levofloxacin
moxifloxacin
isoniazid Not assoc w R - Interim
streptomycin
rifampicin Not assoc w R - Interim
ethambutol
glpK 4139672 c.84C>G synonymous_variant 0.67 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139690 c.66G>A synonymous_variant 0.67 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
embB 4247348 p.Thr279Pro missense_variant 0.32 ethambutol Uncertain significance
embB 4247356 c.843C>G synonymous_variant 0.32 ethambutol
embB 4247363 c.851_854delTATT frameshift_variant 0.33 ethambutol
embB 4247371 c.858_859insCGGG frameshift_variant 0.32 ethambutol
embB 4247389 c.876C>G synonymous_variant 0.61 ethambutol
embB 4247395 c.882C>G synonymous_variant 0.6 ethambutol
embB 4247401 c.888T>C synonymous_variant 0.62 ethambutol
embB 4247428 c.915C>G synonymous_variant 0.62 ethambutol
embB 4247434 c.921C>G synonymous_variant 0.62 ethambutol
embB 4247437 c.924A>G synonymous_variant 0.64 ethambutol Not assoc w R - Interim
embB 4247440 c.927C>G synonymous_variant 0.62 ethambutol
embB 4247455 c.942C>T synonymous_variant 0.62 ethambutol
embB 4247462 c.949_950delTCinsAG synonymous_variant 0.61 ethambutol
embB 4247470 c.957T>C synonymous_variant 0.62 ethambutol
embB 4247497 c.984T>C synonymous_variant 0.6 ethambutol
embB 4247500 c.987C>G synonymous_variant 0.6 ethambutol
embB 4247512 c.999T>C synonymous_variant 0.62 ethambutol
embB 4248133 c.1620C>G synonymous_variant 0.5 ethambutol
embB 4248139 c.1626C>G synonymous_variant 0.5 ethambutol
embB 4248142 c.1629T>C synonymous_variant 0.5 ethambutol
embB 4248143 c.1630T>C synonymous_variant 0.5 ethambutol
embB 4248157 c.1644A>G synonymous_variant 0.69 ethambutol Not assoc w R - Interim
embB 4248167 p.Thr552Ala missense_variant 0.74 ethambutol
embB 4248170 p.Ala553Ser missense_variant 0.74 ethambutol
embB 4248173 p.Val554Met missense_variant 0.78 ethambutol
embB 4248185 c.1672T>C synonymous_variant 0.78 ethambutol
embB 4248190 c.1677G>C synonymous_variant 0.78 ethambutol Not assoc w R - Interim
embB 4248199 c.1686A>G synonymous_variant 0.78 ethambutol
embB 4248200 p.Ile563Val missense_variant 0.78 ethambutol
embB 4248206 p.Ser565Gly missense_variant 0.81 ethambutol Uncertain significance
embB 4248214 c.1701C>G synonymous_variant 0.8 ethambutol
embB 4248220 c.1707A>G synonymous_variant 0.8 ethambutol Not assoc w R - Interim
embB 4248226 c.1713G>C synonymous_variant 0.78 ethambutol
embB 4248241 c.1728C>T synonymous_variant 0.74 ethambutol
embB 4248256 c.1743C>G synonymous_variant 0.71 ethambutol
embB 4248277 c.1764G>C synonymous_variant 0.67 ethambutol
embB 4248280 c.1767C>G synonymous_variant 0.68 ethambutol
embB 4248316 c.1803C>G synonymous_variant 0.4 ethambutol
embB 4248319 c.1806A>C synonymous_variant 0.42 ethambutol