TB-Profiler result

Run: SRR6045050
Summary

Run ID: SRR6045050

Sample name:

Date: 2024-04-16T06:10:02.714275

Number of reads: 2801533

Percentage reads mapped: 77.04

Median coverage: 85.0

Strain: lineage4.3.2.1

Spoligotype:

Drug-resistance: Sensitive

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage4.3 Euro-American (LAM) None 1.0
lineage4.3.2 Euro-American (LAM) None 1.0
lineage4.3.2.1 Euro-American (LAM) RD761 1.0
lineage4 Euro-American None 1.0
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
gyrB 5520 p.Pro94Leu missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7066 c.-236G>C upstream_gene_variant 0.13 levofloxacin
moxifloxacin
gyrA 7078 c.-224A>T upstream_gene_variant 0.16 levofloxacin
moxifloxacin
gyrA 7084 c.-218A>G upstream_gene_variant 0.16 levofloxacin
moxifloxacin
gyrA 7090 c.-212C>T upstream_gene_variant 0.16 levofloxacin
moxifloxacin
gyrB 7093 c.1854T>C synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 7100 c.1861T>C synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7123 c.-179C>G upstream_gene_variant 0.2 levofloxacin
moxifloxacin
gyrB 7126 c.1887G>C synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7129 c.-173T>G upstream_gene_variant 0.17 levofloxacin
moxifloxacin
gyrA 7136 c.-166T>C upstream_gene_variant 0.16 levofloxacin
moxifloxacin
gyrA 7141 c.-161T>C upstream_gene_variant 0.16 levofloxacin
moxifloxacin
gyrA 7144 c.-158A>G upstream_gene_variant 0.16 levofloxacin
moxifloxacin
gyrA 7150 c.-152G>A upstream_gene_variant 0.15 levofloxacin
moxifloxacin
gyrB 7153 c.1914G>C synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7168 c.-134C>G upstream_gene_variant 0.14 levofloxacin
moxifloxacin
gyrB 7222 c.1983C>T synonymous_variant 0.95 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7421 c.120G>C synonymous_variant 0.14 levofloxacin
moxifloxacin
gyrA 7427 c.126G>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 7430 c.129G>A synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 7442 c.141G>C synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 7457 c.156T>C synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 7460 c.159C>T synonymous_variant 0.25 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7463 c.162G>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 7466 c.165G>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 7472 c.171T>C synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7475 c.174A>G synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7480 p.Phe60Tyr missense_variant 0.26 levofloxacin
moxifloxacin
gyrA 7484 c.183T>C synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 7490 c.189C>G synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 7496 c.195C>G synonymous_variant 0.28 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7499 c.198G>C synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 7523 c.222C>G synonymous_variant 0.29 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7526 c.225G>C synonymous_variant 0.28 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7532 c.231T>G synonymous_variant 0.28 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7535 c.234C>G synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 7547 c.246C>T synonymous_variant 0.28 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7559 c.258G>A synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 7569 p.Ala90Ser missense_variant 0.23 levofloxacin
moxifloxacin
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7587 c.286C>T synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7595 c.294C>T synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7601 c.300C>G synonymous_variant 0.14 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7607 c.306C>A synonymous_variant 0.14 levofloxacin
moxifloxacin
gyrA 7625 c.324G>A synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 8915 c.1614A>G synonymous_variant 0.12 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8945 c.1644G>C synonymous_variant 0.12 levofloxacin
moxifloxacin
gyrA 8946 c.1645T>C synonymous_variant 0.14 levofloxacin
moxifloxacin
gyrA 8967 p.Ala556Lys missense_variant 0.2 levofloxacin
moxifloxacin
gyrA 8987 c.1686C>G synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8990 c.1689C>G synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8993 c.1692C>T synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8996 c.1695T>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8998 p.Leu566Trp missense_variant 0.19 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9018 p.Gln573Lys missense_variant 0.18 levofloxacin
moxifloxacin
gyrA 9023 c.1722A>T synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 9026 c.1725G>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 9029 c.1728T>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 9032 c.1731T>C synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 9035 c.1734G>C synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 9044 c.1743C>G synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 9051 c.1750T>C synonymous_variant 0.14 levofloxacin
moxifloxacin
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
rpoB 760487 c.681G>C synonymous_variant 0.12 rifampicin
rpoB 760502 c.696C>G synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoB 760508 c.702G>A synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 760511 c.705G>C synonymous_variant 0.16 rifampicin
rpoB 760522 p.Ser239Asn missense_variant 0.16 rifampicin Uncertain significance
rpoB 760841 c.1035T>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 760858 p.Val351Ala missense_variant 0.15 rifampicin Uncertain significance
rpoB 760862 c.1056G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760869 p.Val355Leu missense_variant 0.17 rifampicin
rpoB 760877 c.1071G>C synonymous_variant 0.16 rifampicin
rpoB 760883 c.1077G>C synonymous_variant 0.16 rifampicin
rpoB 760886 c.1080A>G synonymous_variant 0.16 rifampicin
rpoB 760887 p.Thr361Val missense_variant 0.16 rifampicin Uncertain significance
rpoB 760910 c.1104C>T synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 760916 c.1110C>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 760919 c.1113C>T synonymous_variant 0.14 rifampicin
rpoB 761027 c.1221A>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 761036 c.1230G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 761037 c.1231T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 761051 c.1245G>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 761054 c.1248G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 761057 c.1251G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 761060 c.1254C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 761063 c.1257C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 761084 c.1278C>A synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 761097 c.1291_1293delAGCinsTCG synonymous_variant 0.19 rifampicin
rpoB 761102 c.1296A>G synonymous_variant 0.18 rifampicin
rpoB 761132 c.1326G>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 761133 c.1327T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 761147 c.1341C>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761150 c.1344A>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 761165 c.1359G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761171 c.1365C>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 761178 c.1372_1374delTCAinsAC frameshift_variant&missense_variant 0.15 rifampicin
rpoB 761186 p.Glu460Asp missense_variant 0.14 rifampicin Uncertain significance
rpoB 761189 c.1383T>C synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoB 761195 c.1389G>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 761198 c.1392G>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 761219 c.1413G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761234 c.1428G>C synonymous_variant 0.12 rifampicin Not assoc w R - Interim
rpoB 761273 c.1467T>C synonymous_variant 0.12 rifampicin Not assoc w R - Interim
rpoB 761570 c.1764T>C synonymous_variant 0.11 rifampicin Not assoc w R - Interim
rpoB 761615 c.1809A>C synonymous_variant 0.12 rifampicin Not assoc w R - Interim
rpoB 761636 c.1830G>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 761645 c.1839C>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 761648 c.1842T>C synonymous_variant 0.15 rifampicin
rpoB 761675 c.1869G>T synonymous_variant 0.17 rifampicin
rpoB 761750 c.1944G>C synonymous_variant 0.11 rifampicin
rpoB 762185 c.2379G>C synonymous_variant 0.11 rifampicin Not assoc w R - Interim
rpoB 762194 c.2388G>C synonymous_variant 0.11 rifampicin Not assoc w R - Interim
rpoB 762245 c.2439G>C synonymous_variant 0.12 rifampicin Not assoc w R - Interim
rpoB 762959 c.3153G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 762962 c.3156C>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 762983 c.-387C>T upstream_gene_variant 0.2 rifampicin
rpoB 762989 c.3183G>A synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 762995 c.3189G>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 763034 c.-336C>A upstream_gene_variant 0.22 rifampicin
rpoB 763040 c.3234C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 763070 c.3264T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 763076 c.-294C>A upstream_gene_variant 0.25 rifampicin
rpoB 763082 c.3276C>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 763088 c.3282C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 763094 c.3288G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 763115 c.3309T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 763127 c.3321G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 763136 c.3330C>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 763142 c.-228C>G upstream_gene_variant 0.17 rifampicin
rpoB 763157 c.3351G>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 763166 c.3360A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 763172 c.3366G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 763178 c.-192G>A upstream_gene_variant 0.16 rifampicin
rpoC 763187 c.-183C>G upstream_gene_variant 0.14 rifampicin
rpoC 763486 c.117T>C synonymous_variant 0.12 rifampicin Not assoc w R - Interim
rpoC 763492 c.123G>C synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoC 763528 c.159G>A synonymous_variant 0.12 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 763594 c.225C>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 763618 c.249C>T synonymous_variant 0.15 rifampicin
rpoC 763633 c.264T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 763660 c.291T>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 763666 c.297G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 763669 c.300C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 763675 c.306C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 763699 c.330G>T synonymous_variant 0.21 rifampicin
rpoC 763702 c.333C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 763708 c.339G>T synonymous_variant 0.19 rifampicin
rpoC 763711 c.342G>C synonymous_variant 0.2 rifampicin
rpoC 763714 c.345G>A synonymous_variant 0.18 rifampicin
rpoC 763717 c.348T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 763723 c.354G>C synonymous_variant 0.19 rifampicin
rpoC 763732 c.363C>G synonymous_variant 0.19 rifampicin
rpoC 763741 c.372C>T synonymous_variant 0.16 rifampicin
rpoC 763747 c.378G>A synonymous_variant 0.16 rifampicin
rpoC 763765 c.396T>C synonymous_variant 0.16 rifampicin
rpoC 763768 c.399C>T synonymous_variant 0.16 rifampicin
rpoC 763774 c.405G>C synonymous_variant 0.16 rifampicin
rpoC 763781 c.412_414delTCGinsGC frameshift_variant&missense_variant 0.16 rifampicin
rpoC 763792 p.Glu141Asp missense_variant 0.15 rifampicin
rpoC 763796 p.Met143Leu missense_variant 0.12 rifampicin
rpoC 763801 c.432C>T synonymous_variant 0.12 rifampicin
rpoC 764458 c.1089G>C synonymous_variant 0.12 rifampicin Not assoc w R - Interim
rpoC 764461 c.1092A>G synonymous_variant 0.12 rifampicin Not assoc w R - Interim
rpoC 764497 c.1128A>G synonymous_variant 0.12 rifampicin Not assoc w R - Interim
rpoC 764506 c.1137C>T synonymous_variant 0.12 rifampicin
rpoC 764521 c.1152T>C synonymous_variant 0.11 rifampicin Not assoc w R - Interim
rpoC 764539 c.1170C>G synonymous_variant 0.12 rifampicin Not assoc w R - Interim
rpoC 764548 c.1179G>A synonymous_variant 0.13 rifampicin
rpoC 764554 c.1185C>T synonymous_variant 0.14 rifampicin
rpoC 764566 c.1197C>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764575 c.1206T>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 764578 c.1209C>G synonymous_variant 0.16 rifampicin
rpoC 764593 c.1224C>T synonymous_variant 0.17 rifampicin
rpoC 764602 c.1233C>T synonymous_variant 0.17 rifampicin
rpoC 764611 c.1242G>C synonymous_variant 0.18 rifampicin
rpoC 764626 c.1257C>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764632 c.1263T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764635 c.1266C>T synonymous_variant 0.17 rifampicin
rpoC 764650 c.1281G>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764713 c.1344G>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764746 c.1377G>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764752 c.1383G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764758 c.1389C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764764 c.1395T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764803 c.1434C>T synonymous_variant 0.12 rifampicin Not assoc w R - Interim
rpoC 764995 c.1626C>G synonymous_variant 0.94 rifampicin Not assoc w R
rpoC 765861 p.Phe831Tyr missense_variant 0.14 rifampicin Uncertain significance
rpoC 765868 c.2499G>A synonymous_variant 0.15 rifampicin
rpoC 765871 c.2502T>G synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 765875 p.Val836Ile missense_variant 0.16 rifampicin Uncertain significance
rpoC 765886 c.2517C>G synonymous_variant 0.14 rifampicin
rpoC 765907 c.2538G>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 765928 c.2559C>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 765937 c.2568T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 765940 c.2571A>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 765946 c.2577C>T synonymous_variant 0.17 rifampicin
rpoC 765947 c.2578T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 765962 c.2593_2595delTTGinsCT frameshift_variant&synonymous_variant 0.13 rifampicin
rpoC 765973 c.2604C>T synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 765979 c.2610C>G synonymous_variant 0.12 rifampicin Not assoc w R - Interim
rpoC 765982 c.2613C>T synonymous_variant 0.12 rifampicin Not assoc w R - Interim
rpoC 766594 c.3225G>T synonymous_variant 0.12 rifampicin
rpoC 766607 p.Ile1080Leu missense_variant 0.12 rifampicin
rpoC 766618 c.3249G>T synonymous_variant 0.12 rifampicin
rpoC 767002 c.3633G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 767008 c.3639G>A synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 767044 c.3675G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 767080 c.3711G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 767098 c.3729T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 767100 p.Lys1244Arg missense_variant 0.2 rifampicin
rpoC 767104 c.3735C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 767107 c.3738C>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 767119 c.3750A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 767125 c.3756G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 767134 c.3765C>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 767138 c.3769C>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
mmpL5 775639 p.Ile948Val missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
atpE 1461132 p.Val30Ile missense_variant 0.17 bedaquiline
atpE 1461149 c.105T>G synonymous_variant 0.15 bedaquiline
atpE 1461155 c.111C>G synonymous_variant 0.15 bedaquiline
atpE 1461161 c.117C>G synonymous_variant 0.15 bedaquiline
atpE 1461167 c.123G>T synonymous_variant 0.14 bedaquiline
atpE 1461170 c.126A>G synonymous_variant 0.13 bedaquiline
atpE 1461179 c.135G>T synonymous_variant 0.12 bedaquiline
atpE 1461182 c.138A>G synonymous_variant 0.12 bedaquiline
atpE 1461183 c.139_141delGGGinsAC frameshift_variant&missense_variant 0.12 bedaquiline
atpE 1461197 c.153A>C synonymous_variant 0.12 bedaquiline
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471985 n.140T>C non_coding_transcript_exon_variant 0.25 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471986 n.141C>T non_coding_transcript_exon_variant 0.25 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472106 n.261G>A non_coding_transcript_exon_variant 0.31 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.31 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472113 n.268T>C non_coding_transcript_exon_variant 0.29 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472337 n.492C>T non_coding_transcript_exon_variant 0.64 streptomycin Not assoc w R - Interim
kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472380 n.535G>C non_coding_transcript_exon_variant 0.68 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472446 n.601T>A non_coding_transcript_exon_variant 0.75 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472452 n.607G>A non_coding_transcript_exon_variant 0.79 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472464 n.619A>G non_coding_transcript_exon_variant 0.71 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472612 n.767G>T non_coding_transcript_exon_variant 0.57 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472734 n.889C>T non_coding_transcript_exon_variant 0.83 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472741 n.896G>A non_coding_transcript_exon_variant 0.79 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472846 n.1001C>T non_coding_transcript_exon_variant 0.65 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472847 n.1002G>A non_coding_transcript_exon_variant 0.64 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472848 n.1003T>C non_coding_transcript_exon_variant 0.62 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472860 n.1015C>T non_coding_transcript_exon_variant 0.65 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472861 n.1016G>A non_coding_transcript_exon_variant 0.65 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472956 n.1111T>C non_coding_transcript_exon_variant 0.47 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472957 n.1112C>T non_coding_transcript_exon_variant 0.47 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472969 n.1124A>G non_coding_transcript_exon_variant 0.46 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472970 n.1125C>G non_coding_transcript_exon_variant 0.46 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472977 n.1132G>C non_coding_transcript_exon_variant 0.45 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472978 n.1133T>C non_coding_transcript_exon_variant 0.45 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472989 n.1144G>A non_coding_transcript_exon_variant 0.46 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472990 n.1145A>G non_coding_transcript_exon_variant 0.5 streptomycin Uncertain significance
kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1473082 n.1237G>A non_coding_transcript_exon_variant 0.43 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473088 n.1243A>G non_coding_transcript_exon_variant 0.43 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473099 n.1254T>A non_coding_transcript_exon_variant 0.48 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473105 n.1260G>A non_coding_transcript_exon_variant 0.47 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473110 n.1265T>G non_coding_transcript_exon_variant 0.45 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473111 n.1266A>G non_coding_transcript_exon_variant 0.45 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473121 n.1276T>C non_coding_transcript_exon_variant 0.42 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1473123 n.1278A>T non_coding_transcript_exon_variant 0.43 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473129 n.1284C>T non_coding_transcript_exon_variant 0.48 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.56 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.5 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473288 n.1443C>T non_coding_transcript_exon_variant 0.24 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473290 n.1445C>T non_coding_transcript_exon_variant 0.24 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473291 n.1446G>T non_coding_transcript_exon_variant 0.24 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrl 1473806 n.149C>T non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473812 n.155G>A non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid
rrl 1473814 n.157A>T non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid
rrl 1473815 n.158T>G non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid
rrl 1473829 n.172G>C non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid
rrl 1473832 n.175C>T non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid
rrl 1473839 n.182G>A non_coding_transcript_exon_variant 0.43 capreomycin Uncertain significance
linezolid
rrl 1473876 n.219G>A non_coding_transcript_exon_variant 0.61 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473887 n.230T>C non_coding_transcript_exon_variant 0.65 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473888 n.231T>C non_coding_transcript_exon_variant 0.65 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473898 n.241C>T non_coding_transcript_exon_variant 0.65 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473899 n.242A>G non_coding_transcript_exon_variant 0.65 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473916 n.259C>A non_coding_transcript_exon_variant 0.6 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473923 n.266C>G non_coding_transcript_exon_variant 0.6 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473924 n.267_268insT non_coding_transcript_exon_variant 0.6 capreomycin
linezolid
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474263 n.606G>A non_coding_transcript_exon_variant 0.54 capreomycin Uncertain significance
linezolid
rrl 1474282 n.625G>A non_coding_transcript_exon_variant 0.54 capreomycin Uncertain significance
linezolid
rrl 1474292 n.636_649delTCCTCTCCGGAGGA non_coding_transcript_exon_variant 0.58 capreomycin
linezolid
rrl 1474308 n.651G>T non_coding_transcript_exon_variant 0.58 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474310 n.653T>G non_coding_transcript_exon_variant 0.58 capreomycin
linezolid
rrl 1474356 n.699T>C non_coding_transcript_exon_variant 0.75 capreomycin Uncertain significance
linezolid
rrl 1474362 n.705A>G non_coding_transcript_exon_variant 0.77 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474496 n.839C>G non_coding_transcript_exon_variant 0.91 capreomycin Uncertain significance
linezolid
rrl 1474497 n.840G>C non_coding_transcript_exon_variant 0.91 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474743 n.1086T>G non_coding_transcript_exon_variant 0.92 capreomycin Uncertain significance
linezolid
rrl 1474760 n.1103A>G non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474803 n.1146G>A non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475090 n.1433A>T non_coding_transcript_exon_variant 0.9 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475114 n.1457C>T non_coding_transcript_exon_variant 0.9 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475129 n.1472G>A non_coding_transcript_exon_variant 0.9 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475760 n.2105_2106delGC non_coding_transcript_exon_variant 0.6 capreomycin
linezolid
rrl 1475764 n.2107A>T non_coding_transcript_exon_variant 0.6 capreomycin
linezolid
rrl 1475765 n.2108A>T non_coding_transcript_exon_variant 0.6 capreomycin
linezolid
rrl 1476214 n.2557G>T non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476215 n.2558C>T non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476221 n.2564T>C non_coding_transcript_exon_variant 0.53 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.57 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476260 n.2603A>G non_coding_transcript_exon_variant 0.59 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.59 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476295 n.2638C>T non_coding_transcript_exon_variant 0.48 capreomycin
linezolid
rrl 1476297 n.2640C>T non_coding_transcript_exon_variant 0.48 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476299 n.2642C>T non_coding_transcript_exon_variant 0.48 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476311 n.2654G>A non_coding_transcript_exon_variant 0.48 capreomycin
linezolid
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.31 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476594 n.2937C>T non_coding_transcript_exon_variant 0.26 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476597 n.2940G>A non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid
rrl 1476603 n.2946G>A non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476608 n.2951C>G non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476619 n.2962C>T non_coding_transcript_exon_variant 0.19 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid Uncertain significance
rpsA 1833709 c.168C>T synonymous_variant 0.14 pyrazinamide
rpsA 1833727 c.186G>C synonymous_variant 0.11 pyrazinamide
rpsA 1833874 c.333T>G synonymous_variant 0.12 pyrazinamide
rpsA 1833886 c.345C>G synonymous_variant 0.12 pyrazinamide
rpsA 1833892 c.351G>A synonymous_variant 0.12 pyrazinamide
rpsA 1833894 p.Ala118Glu missense_variant 0.13 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.17 pyrazinamide
rpsA 1833949 c.408T>C synonymous_variant 0.2 pyrazinamide
rpsA 1833970 c.429G>C synonymous_variant 0.16 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.15 pyrazinamide
rpsA 1833991 c.450C>G synonymous_variant 0.14 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.13 pyrazinamide
rpsA 1834009 c.468C>T synonymous_variant 0.12 pyrazinamide
rpsA 1834015 c.474G>C synonymous_variant 0.11 pyrazinamide
rpsA 1834297 c.756C>T synonymous_variant 0.14 pyrazinamide
rpsA 1834303 c.762T>G synonymous_variant 0.14 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.15 pyrazinamide
rpsA 1834339 c.798C>T synonymous_variant 0.15 pyrazinamide
rpsA 1834378 c.837T>C synonymous_variant 0.12 pyrazinamide Not assoc w R - Interim
rpsA 1834396 c.855G>T synonymous_variant 0.15 pyrazinamide
rpsA 1834405 c.864C>T synonymous_variant 0.15 pyrazinamide
rpsA 1834408 c.867C>T synonymous_variant 0.15 pyrazinamide
rpsA 1834411 c.870T>C synonymous_variant 0.14 pyrazinamide
rpsA 1834417 c.876G>C synonymous_variant 0.15 pyrazinamide
rpsA 1834423 c.882G>C synonymous_variant 0.14 pyrazinamide
rpsA 1834435 c.894G>C synonymous_variant 0.13 pyrazinamide
rpsA 1834451 c.910T>C synonymous_variant 0.13 pyrazinamide
rpsA 1834456 c.915T>G synonymous_variant 0.17 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.15 pyrazinamide
rpsA 1834480 c.939C>G synonymous_variant 0.15 pyrazinamide
rpsA 1834483 c.942G>A synonymous_variant 0.15 pyrazinamide
rpsA 1834489 c.948T>C synonymous_variant 0.16 pyrazinamide
rpsA 1834498 c.957C>T synonymous_variant 0.16 pyrazinamide
rpsA 1834520 p.Ala327Ser missense_variant 0.18 pyrazinamide
rpsA 1834528 c.987T>C synonymous_variant 0.19 pyrazinamide
rpsA 1834543 c.1002C>G synonymous_variant 0.18 pyrazinamide
rpsA 1834552 c.1011G>T synonymous_variant 0.17 pyrazinamide
rpsA 1834555 c.1014T>G synonymous_variant 0.17 pyrazinamide
rpsA 1834557 p.Ala339Gly missense_variant 0.17 pyrazinamide
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
thyA 3073868 p.Thr202Ala missense_variant 0.99 para-aminosalicylic_acid
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
mtrB 3625065 p.Met517Leu missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
rpoA 3877752 p.Asp252Glu missense_variant 0.12 rifampicin
rpoA 3877758 c.750G>C synonymous_variant 0.13 rifampicin
rpoA 3877764 c.744C>G synonymous_variant 0.12 rifampicin Not assoc w R - Interim
rpoA 3877770 c.738A>G synonymous_variant 0.12 rifampicin Not assoc w R - Interim
rpoA 3877776 c.732T>C synonymous_variant 0.12 rifampicin Not assoc w R - Interim
rpoA 3877782 c.726T>C synonymous_variant 0.11 rifampicin Not assoc w R - Interim
rpoA 3877818 c.690A>G synonymous_variant 0.12 rifampicin Not assoc w R - Interim
clpC1 4038287 c.2418C>T synonymous_variant 1.0 pyrazinamide Not assoc w R
clpC1 4039265 c.1440C>T synonymous_variant 0.21 pyrazinamide
clpC1 4039274 c.1431G>C synonymous_variant 0.22 pyrazinamide Not assoc w R - Interim
clpC1 4039277 c.1428C>G synonymous_variant 0.25 pyrazinamide
clpC1 4039280 c.1425G>T synonymous_variant 0.22 pyrazinamide Not assoc w R - Interim
clpC1 4039283 c.1422C>T synonymous_variant 0.23 pyrazinamide
clpC1 4039286 c.1419T>G synonymous_variant 0.23 pyrazinamide
clpC1 4039292 c.1413C>T synonymous_variant 0.23 pyrazinamide
clpC1 4039316 p.Glu463Asp missense_variant 0.23 pyrazinamide
clpC1 4039319 c.1386T>A synonymous_variant 0.23 pyrazinamide
clpC1 4039322 c.1383T>G synonymous_variant 0.23 pyrazinamide
clpC1 4039328 c.1377A>C synonymous_variant 0.23 pyrazinamide
clpC1 4039338 p.Thr456Gln missense_variant 0.22 pyrazinamide
clpC1 4039346 p.Arg453Ser missense_variant 0.22 pyrazinamide
clpC1 4039360 p.Ser449Arg missense_variant 0.24 pyrazinamide
clpC1 4039361 c.1344C>G synonymous_variant 0.24 pyrazinamide
clpC1 4039391 c.1314T>C synonymous_variant 0.24 pyrazinamide
clpC1 4039397 c.1308A>G synonymous_variant 0.27 pyrazinamide
clpC1 4039409 c.1296T>C synonymous_variant 0.28 pyrazinamide
clpC1 4039412 c.1293T>G synonymous_variant 0.28 pyrazinamide
clpC1 4039415 p.Glu430Asp missense_variant 0.27 pyrazinamide Uncertain significance
clpC1 4039430 c.1275T>C synonymous_variant 0.27 pyrazinamide
clpC1 4039442 c.1263A>G synonymous_variant 0.26 pyrazinamide
clpC1 4039451 c.1254G>A synonymous_variant 0.23 pyrazinamide
clpC1 4039454 c.1251A>T synonymous_variant 0.23 pyrazinamide
clpC1 4039457 c.1248C>T synonymous_variant 0.23 pyrazinamide
clpC1 4039463 c.1242C>G synonymous_variant 0.23 pyrazinamide
clpC1 4039466 c.1239T>C synonymous_variant 0.23 pyrazinamide
clpC1 4039469 c.1236T>C synonymous_variant 0.25 pyrazinamide
clpC1 4039472 c.1233G>C synonymous_variant 0.24 pyrazinamide
clpC1 4039478 c.1227G>C synonymous_variant 0.23 pyrazinamide
clpC1 4039481 c.1224T>C synonymous_variant 0.23 pyrazinamide
clpC1 4039487 c.1218G>C synonymous_variant 0.2 pyrazinamide
clpC1 4039517 c.1188C>G synonymous_variant 0.16 pyrazinamide
clpC1 4039522 c.1183C>T synonymous_variant 0.16 pyrazinamide
clpC1 4039541 c.1164C>G synonymous_variant 0.14 pyrazinamide
clpC1 4039610 c.1095G>C synonymous_variant 0.15 pyrazinamide
clpC1 4039616 c.1089G>C synonymous_variant 0.17 pyrazinamide
clpC1 4039622 c.1083C>T synonymous_variant 0.17 pyrazinamide
clpC1 4039649 c.1056G>T synonymous_variant 0.2 pyrazinamide
clpC1 4039652 c.1053G>C synonymous_variant 0.21 pyrazinamide
clpC1 4039685 c.1020C>T synonymous_variant 0.23 pyrazinamide
clpC1 4039694 c.1011G>C synonymous_variant 0.23 pyrazinamide
clpC1 4039724 c.981A>G synonymous_variant 0.27 pyrazinamide
clpC1 4039733 c.972G>C synonymous_variant 0.27 pyrazinamide
clpC1 4039739 c.966C>G synonymous_variant 0.26 pyrazinamide
clpC1 4039751 c.954A>G synonymous_variant 0.27 pyrazinamide
clpC1 4039757 c.948A>G synonymous_variant 0.28 pyrazinamide
clpC1 4039760 c.945T>C synonymous_variant 0.28 pyrazinamide
clpC1 4039766 c.939T>C synonymous_variant 0.28 pyrazinamide
clpC1 4039769 c.936C>G synonymous_variant 0.28 pyrazinamide
clpC1 4039775 c.930G>C synonymous_variant 0.29 pyrazinamide
clpC1 4039778 c.927A>G synonymous_variant 0.29 pyrazinamide
clpC1 4039787 c.918G>C synonymous_variant 0.29 pyrazinamide
clpC1 4039793 c.912C>G synonymous_variant 0.26 pyrazinamide
clpC1 4039805 c.900C>T synonymous_variant 0.26 pyrazinamide Not assoc w R - Interim
clpC1 4039814 c.891C>G synonymous_variant 0.25 pyrazinamide
clpC1 4039817 c.888A>C synonymous_variant 0.24 pyrazinamide Not assoc w R - Interim
clpC1 4039820 c.885T>G synonymous_variant 0.24 pyrazinamide
clpC1 4039831 c.874T>C synonymous_variant 0.27 pyrazinamide
clpC1 4039844 c.861C>T synonymous_variant 0.27 pyrazinamide Not assoc w R - Interim
clpC1 4039850 c.855T>C synonymous_variant 0.26 pyrazinamide
clpC1 4039865 c.840T>C synonymous_variant 0.26 pyrazinamide
clpC1 4039904 c.801A>G synonymous_variant 0.24 pyrazinamide
clpC1 4039907 c.798G>A synonymous_variant 0.23 pyrazinamide Not assoc w R - Interim
clpC1 4039931 c.774T>C synonymous_variant 0.21 pyrazinamide
clpC1 4039934 c.771G>C synonymous_variant 0.2 pyrazinamide
clpC1 4039943 c.762G>C synonymous_variant 0.18 pyrazinamide
clpC1 4039946 c.759A>G synonymous_variant 0.19 pyrazinamide
clpC1 4039949 c.756G>C synonymous_variant 0.19 pyrazinamide
clpC1 4039952 c.753T>C synonymous_variant 0.19 pyrazinamide
clpC1 4039958 c.747G>C synonymous_variant 0.18 pyrazinamide
clpC1 4039964 c.741C>G synonymous_variant 0.18 pyrazinamide
clpC1 4039975 p.Asp244Asn missense_variant 0.19 pyrazinamide Uncertain significance
clpC1 4039979 c.726C>G synonymous_variant 0.18 pyrazinamide
clpC1 4039982 c.723G>A synonymous_variant 0.18 pyrazinamide Not assoc w R - Interim
clpC1 4040000 c.705C>T synonymous_variant 0.18 pyrazinamide
clpC1 4040021 c.684A>C synonymous_variant 0.15 pyrazinamide Not assoc w R - Interim
clpC1 4040024 c.681A>G synonymous_variant 0.14 pyrazinamide
clpC1 4040033 c.672G>C synonymous_variant 0.13 pyrazinamide
embC 4242643 c.2781C>T synonymous_variant 0.99 ethambutol Not assoc w R
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 capreomycin
amikacin
kanamycin
gid 4408156 p.Leu16Arg missense_variant 1.0 streptomycin Not assoc w R