TB-Profiler result

Run: eec80340-97df-489d-a624-224c57d5fe25
Summary

Run ID: eec80340-97df-489d-a624-224c57d5fe25

Sample name:

Date: 30-08-2023 11:13:05

Number of reads: 894430

Percentage reads mapped: 83.94

Median coverage: 32

Strain: lineage4.9

Spoligotype:

Drug-resistance: XDR-TB

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage4 Euro-American None 1.0
lineage4.9 Euro-American (H37Rv-like) None 0.97
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin rpoB p.Gln432Pro Assoc w R
isoniazid katG p.Ser315Asn Assoc w R
ethambutol embB p.Met306Ile Assoc w R
pyrazinamide
moxifloxacin gyrB p.Asn499Asp Assoc w R - interim
levofloxacin gyrB p.Asn499Asp Assoc w R - interim
bedaquiline
delamanid
pretomanid
linezolid rplC p.Cys154Arg Assoc w R
streptomycin
amikacin
kanamycin
capreomycin
clofazimine
ethionamide
para-aminosalicylic_acid
cycloserine
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
gyrB 6734 p.Asn499Asp missense_variant 1.0 ofloxacin Uncertain significance
moxifloxacin Assoc w R - interim
levofloxacin Assoc w R - interim
fluoroquinolones Uncertain significance
ciprofloxacin Uncertain significance
rpoB 761101 p.Gln432Pro missense_variant 0.94 rifampicin Assoc w R
rplC 801268 p.Cys154Arg missense_variant 0.93 linezolid Assoc w R
katG 2155168 p.Ser315Asn missense_variant 1.0 isoniazid Assoc w R
embB 4247431 p.Met306Ile missense_variant 1.0 ethambutol Assoc w R
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
gyrA 7362 p.Glu21Gln missense_variant 1.0 fluoroquinolones
moxifloxacin Uncertain significance
levofloxacin Uncertain significance
ciprofloxacin
ofloxacin
gyrA 7622 c.321C>T synonymous_variant 0.11 fluoroquinolones
moxifloxacin
levofloxacin
ciprofloxacin
ofloxacin
gyrA 7631 c.330G>C synonymous_variant 0.12 fluoroquinolones
moxifloxacin
levofloxacin
ciprofloxacin
ofloxacin
gyrA 7637 c.336C>A synonymous_variant 0.12 fluoroquinolones
moxifloxacin
levofloxacin
ciprofloxacin
ofloxacin
gyrA 8366 c.1065G>C synonymous_variant 0.12 fluoroquinolones
moxifloxacin
levofloxacin
ciprofloxacin
ofloxacin
gyrA 8372 c.1071G>T synonymous_variant 0.11 fluoroquinolones
moxifloxacin
levofloxacin
ciprofloxacin
ofloxacin
gyrA 8390 c.1089C>G synonymous_variant 0.12 fluoroquinolones
moxifloxacin
levofloxacin
ciprofloxacin
ofloxacin
gyrA 8391 p.Tyr364Leu missense_variant 0.16 fluoroquinolones
moxifloxacin
levofloxacin
ciprofloxacin
ofloxacin
gyrA 8399 c.1098T>G synonymous_variant 0.13 fluoroquinolones
moxifloxacin
levofloxacin
ciprofloxacin
ofloxacin
gyrA 8405 c.1104C>T synonymous_variant 0.14 fluoroquinolones
moxifloxacin
levofloxacin
ciprofloxacin
ofloxacin
gyrA 8408 c.1107A>G synonymous_variant 0.14 fluoroquinolones
moxifloxacin
levofloxacin
ciprofloxacin
ofloxacin
gyrA 8414 c.1113C>T synonymous_variant 0.13 fluoroquinolones
moxifloxacin
levofloxacin
ciprofloxacin
ofloxacin
gyrA 8420 c.1119T>C synonymous_variant 0.12 fluoroquinolones
moxifloxacin
levofloxacin
ciprofloxacin
ofloxacin
gyrA 8433 p.Thr378Arg missense_variant 0.1 fluoroquinolones
moxifloxacin
levofloxacin
ciprofloxacin
ofloxacin
gyrA 8442 c.1141C>T synonymous_variant 0.16 fluoroquinolones
moxifloxacin
levofloxacin
ciprofloxacin
ofloxacin
gyrA 8453 c.1152A>C synonymous_variant 0.16 fluoroquinolones
moxifloxacin
levofloxacin
ciprofloxacin
ofloxacin
gyrA 8456 c.1155C>T synonymous_variant 0.16 fluoroquinolones
moxifloxacin
levofloxacin
ciprofloxacin
ofloxacin
gyrA 8459 c.1158G>A synonymous_variant 0.16 fluoroquinolones
moxifloxacin
levofloxacin
ciprofloxacin
ofloxacin
gyrA 8462 c.1161A>G synonymous_variant 0.15 fluoroquinolones
moxifloxacin
levofloxacin
ciprofloxacin
ofloxacin
gyrA 8471 c.1170T>C synonymous_variant 0.14 fluoroquinolones
moxifloxacin
levofloxacin
ciprofloxacin
ofloxacin
gyrA 8477 c.1176C>T synonymous_variant 0.15 fluoroquinolones
moxifloxacin
levofloxacin
ciprofloxacin
ofloxacin
gyrA 8480 c.1179C>T synonymous_variant 0.14 fluoroquinolones
moxifloxacin
levofloxacin
ciprofloxacin
ofloxacin
gyrA 8486 c.1185T>C synonymous_variant 0.13 fluoroquinolones
moxifloxacin
levofloxacin
ciprofloxacin
ofloxacin
gyrA 8504 c.1203G>C synonymous_variant 0.13 fluoroquinolones
moxifloxacin
levofloxacin
ciprofloxacin
ofloxacin
gyrA 8535 p.Glu412Gln missense_variant 0.1 fluoroquinolones
moxifloxacin
levofloxacin
ciprofloxacin
ofloxacin
gyrA 8561 c.1260A>C synonymous_variant 0.1 fluoroquinolones
moxifloxacin
levofloxacin
ciprofloxacin
ofloxacin
gyrA 8571 c.1270C>T synonymous_variant 0.11 fluoroquinolones
moxifloxacin
levofloxacin
ciprofloxacin
ofloxacin
mshA 575725 c.378C>G synonymous_variant 0.13 ethionamide
isoniazid
mshA 575734 c.387T>G synonymous_variant 0.13 ethionamide
isoniazid
mshA 575744 p.Ala133Thr missense_variant 0.13 ethionamide
isoniazid
mshA 575749 c.402C>A synonymous_variant 0.13 ethionamide
isoniazid
mshA 575761 c.414C>T synonymous_variant 0.86 ethionamide
isoniazid
mshA 575764 c.417C>G synonymous_variant 0.14 ethionamide
isoniazid
mshA 575771 p.Val142Thr missense_variant 0.16 ethionamide
isoniazid
mshA 575776 c.429C>T synonymous_variant 0.15 ethionamide
isoniazid
mshA 575782 c.435G>C synonymous_variant 0.15 ethionamide
isoniazid
mshA 575785 c.438T>C synonymous_variant 0.15 ethionamide
isoniazid
mshA 575795 p.Ile150Val missense_variant 0.15 ethionamide
isoniazid
mshA 575800 c.453G>C synonymous_variant 0.15 ethionamide
isoniazid
mshA 575803 c.456C>T synonymous_variant 0.15 ethionamide
isoniazid
mshA 575821 c.474G>C synonymous_variant 0.16 ethionamide
isoniazid
mshA 575842 c.495G>C synonymous_variant 0.19 ethionamide
isoniazid
mshA 575864 c.517T>C synonymous_variant 0.16 ethionamide
isoniazid
rpoB 759814 p.Asp3Gly missense_variant 1.0 rifampicin Uncertain significance
rpoB 760244 c.438G>C synonymous_variant 0.11 rifampicin
rpoB 760283 c.477G>C synonymous_variant 0.16 rifampicin
rpoB 760298 c.492G>C synonymous_variant 0.17 rifampicin
rpoB 760310 c.504G>C synonymous_variant 0.2 rifampicin
rpoB 760316 c.510C>G synonymous_variant 0.22 rifampicin
rpoB 760325 c.519G>C synonymous_variant 0.21 rifampicin
rpoB 760331 c.525G>C synonymous_variant 0.21 rifampicin
rpoB 760334 c.528G>T synonymous_variant 0.21 rifampicin
rpoB 760340 c.534G>T synonymous_variant 0.19 rifampicin
rpoB 760357 p.Thr184Ser missense_variant 0.17 rifampicin
rpoB 760361 c.555T>C synonymous_variant 0.16 rifampicin
rpoB 760376 p.Asp190Glu missense_variant 0.14 rifampicin
rpoB 760406 c.600G>T synonymous_variant 0.13 rifampicin
rpoB 760407 p.Ser201Gly missense_variant 0.16 rifampicin
rpoB 760415 c.609C>T synonymous_variant 0.16 rifampicin
rpoB 760424 c.618C>G synonymous_variant 0.11 rifampicin
rpoB 760674 c.868T>C synonymous_variant 0.11 rifampicin
rpoB 760721 c.915C>G synonymous_variant 0.11 rifampicin
rpoB 760724 c.918T>C synonymous_variant 0.11 rifampicin
rpoB 760730 c.924T>C synonymous_variant 0.12 rifampicin
rpoB 760748 c.942C>G synonymous_variant 0.11 rifampicin
rpoB 760751 c.945G>C synonymous_variant 0.11 rifampicin
rpoB 760755 p.His317Asn missense_variant 0.11 rifampicin
rpoB 760759 p.Val318Ala missense_variant 0.11 rifampicin
rpoB 760764 p.Glu320Gln missense_variant 0.11 rifampicin
rpoB 760769 c.963C>G synonymous_variant 0.13 rifampicin
rpoB 760784 c.978G>T synonymous_variant 0.14 rifampicin
rpoB 760793 c.987A>G synonymous_variant 0.15 rifampicin
rpoB 760805 c.999G>C synonymous_variant 0.15 rifampicin
rpoB 760817 c.1011A>G synonymous_variant 0.15 rifampicin
rpoB 760820 c.1014T>C synonymous_variant 0.17 rifampicin
rpoB 760826 c.1020C>G synonymous_variant 0.14 rifampicin
rpoB 760830 c.1024T>C synonymous_variant 0.15 rifampicin
rpoB 760841 c.1035T>C synonymous_variant 0.13 rifampicin
rpoB 760859 c.1053T>C synonymous_variant 0.15 rifampicin
rpoB 760862 c.1056G>C synonymous_variant 0.15 rifampicin
rpoB 760877 c.1071G>C synonymous_variant 0.15 rifampicin
rpoB 760883 c.1077G>C synonymous_variant 0.15 rifampicin
rpoB 760886 c.1080A>G synonymous_variant 0.15 rifampicin
rpoB 760887 p.Thr361Val missense_variant 0.15 rifampicin
rpoB 760910 c.1104C>T synonymous_variant 0.21 rifampicin
rpoB 760916 c.1110C>T synonymous_variant 0.17 rifampicin
rpoB 760919 c.1113C>T synonymous_variant 0.17 rifampicin
rpoB 760925 c.1119T>C synonymous_variant 0.16 rifampicin
rpoB 760928 c.1122G>C synonymous_variant 0.16 rifampicin
rpoB 760931 c.1125C>G synonymous_variant 0.16 rifampicin
rpoB 760946 c.1140A>G synonymous_variant 0.16 rifampicin
rpoB 760958 c.1152G>C synonymous_variant 0.16 rifampicin
rpoB 760965 p.Met387Leu missense_variant 0.16 rifampicin
rpoB 760970 c.1164G>C synonymous_variant 0.13 rifampicin
rpoB 760973 c.1167G>C synonymous_variant 0.1 rifampicin
rpoB 760982 c.1176G>C synonymous_variant 0.1 rifampicin
rpoB 760997 c.1191G>C synonymous_variant 0.12 rifampicin
rpoB 761015 c.1209G>C synonymous_variant 0.1 rifampicin
rpoB 761027 c.1221A>C synonymous_variant 0.1 rifampicin
rpoB 761036 c.1230G>C synonymous_variant 0.1 rifampicin
rpoB 761037 c.1231T>C synonymous_variant 0.11 rifampicin
rpoB 761147 c.1341C>T synonymous_variant 0.11 rifampicin
rpoB 761150 c.1344A>T synonymous_variant 0.11 rifampicin
rpoB 761249 c.1443A>G synonymous_variant 0.11 rifampicin
rpoB 761261 c.1455G>T synonymous_variant 0.11 rifampicin
rpoB 761264 c.1458C>G synonymous_variant 0.11 rifampicin
rpoB 761282 c.1476C>T synonymous_variant 0.11 rifampicin
rpoB 761288 c.1482G>T synonymous_variant 0.11 rifampicin
rpoB 762293 c.2487T>C synonymous_variant 0.11 rifampicin
rpoB 762308 c.2502G>C synonymous_variant 0.11 rifampicin
rpoB 762347 c.2541T>C synonymous_variant 0.1 rifampicin
rpoB 762350 c.2544C>T synonymous_variant 0.11 rifampicin
rpoB 762362 p.Glu852Asp missense_variant 0.13 rifampicin
rpoB 762369 c.2563T>C synonymous_variant 0.14 rifampicin
rpoC 762374 c.-996G>C upstream_gene_variant 0.14 rifampicin
rpoC 762416 c.-954A>G upstream_gene_variant 0.11 rifampicin
rpoC 762434 c.-936T>C upstream_gene_variant 0.11 rifampicin
rpoC 762443 c.-927G>C upstream_gene_variant 0.11 rifampicin
rpoC 763031 c.-339T>G upstream_gene_variant 0.11 rifampicin
rpoC 763618 c.249C>T synonymous_variant 0.11 rifampicin
rpoC 763633 c.264T>C synonymous_variant 0.14 rifampicin
rpoC 763660 c.291T>G synonymous_variant 0.13 rifampicin
rpoC 763666 c.297G>A synonymous_variant 0.12 rifampicin
rpoC 763675 c.306C>G synonymous_variant 0.14 rifampicin
rpoC 763702 c.333C>G synonymous_variant 0.15 rifampicin
rpoC 763709 c.340C>T synonymous_variant 0.14 rifampicin
rpoC 763714 c.345G>C synonymous_variant 0.13 rifampicin
rpoC 763717 c.348T>C synonymous_variant 0.13 rifampicin
rpoC 763723 c.354G>C synonymous_variant 0.12 rifampicin
rpoC 763732 c.363C>T synonymous_variant 0.15 rifampicin
rpoC 763741 c.372C>T synonymous_variant 0.17 rifampicin
rpoC 763747 c.378G>A synonymous_variant 0.16 rifampicin
rpoC 763765 c.396T>G synonymous_variant 0.14 rifampicin
rpoC 763792 p.Glu141Asp missense_variant 0.12 rifampicin
rpoC 763807 c.438T>C synonymous_variant 0.14 rifampicin
rpoC 763813 c.444C>G synonymous_variant 0.13 rifampicin
rpoC 764263 c.894G>C synonymous_variant 0.12 rifampicin
rpoC 764266 c.897T>C synonymous_variant 0.12 rifampicin
rpoC 764272 c.903G>C synonymous_variant 0.12 rifampicin
rpoC 764278 c.909A>G synonymous_variant 0.12 rifampicin
rpoC 764293 c.924G>C synonymous_variant 0.11 rifampicin
rpoC 764297 p.Met310Leu missense_variant 0.1 rifampicin
rpoC 764344 c.975C>T synonymous_variant 0.16 rifampicin
rpoC 764353 c.984G>T synonymous_variant 0.15 rifampicin
rpoC 764365 c.996C>T synonymous_variant 0.14 rifampicin
rpoC 764371 c.1002G>C synonymous_variant 0.13 rifampicin
rpoC 764380 c.1011G>C synonymous_variant 0.12 rifampicin
rpoC 764387 c.1018T>C synonymous_variant 0.12 rifampicin
rpoC 764632 c.1263T>C synonymous_variant 0.12 rifampicin
rpoC 764650 c.1281G>T synonymous_variant 0.13 rifampicin
rpoC 764666 p.Gly433Ser missense_variant 0.5 rifampicin
rpoC 764701 c.1332C>G synonymous_variant 0.11 rifampicin
rpoC 764713 c.1344G>T synonymous_variant 0.13 rifampicin
rpoC 764716 c.1347G>C synonymous_variant 0.13 rifampicin
rpoC 764746 c.1377G>T synonymous_variant 0.14 rifampicin
mmpL5 775639 p.Ile948Val missense_variant 1.0 clofazimine Uncertain significance
bedaquiline Uncertain significance
mmpR5 779181 c.198delG frameshift_variant 1.0 clofazimine Uncertain significance
bedaquiline Uncertain significance
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Uncertain significance
rpsL 781502 c.-58G>T upstream_gene_variant 1.0 streptomycin Uncertain significance
rpsL 781892 c.333A>G synonymous_variant 0.1 streptomycin
rpsL 781898 c.339A>C synonymous_variant 0.1 streptomycin
rpsL 781901 c.342C>T synonymous_variant 0.1 streptomycin
rpsL 781907 c.348T>C synonymous_variant 0.12 streptomycin
rpsL 781916 c.357T>C synonymous_variant 0.11 streptomycin
rpsL 781929 p.Gly124Ser missense_variant 0.12 streptomycin Uncertain significance
rplC 800612 c.-197A>G upstream_gene_variant 0.13 linezolid
rplC 800618 c.-191T>C upstream_gene_variant 0.13 linezolid Uncertain significance
rplC 800633 c.-176T>C upstream_gene_variant 0.13 linezolid
rplC 800645 c.-164C>G upstream_gene_variant 0.14 linezolid
rplC 800648 c.-161A>G upstream_gene_variant 0.16 linezolid Uncertain significance
rplC 800654 c.-155T>C upstream_gene_variant 0.12 linezolid
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1471986 n.141C>T non_coding_transcript_exon_variant 0.18 linezolid
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
aminoglycosides
streptomycin Uncertain significance
rrs 1472019 n.174G>A non_coding_transcript_exon_variant 0.19 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1472023 n.178G>T non_coding_transcript_exon_variant 0.2 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1472031 n.186G>C non_coding_transcript_exon_variant 0.16 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1472033 n.188A>C non_coding_transcript_exon_variant 0.16 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1472035 n.190G>T non_coding_transcript_exon_variant 0.16 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1472040 n.195T>G non_coding_transcript_exon_variant 0.16 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1472041 n.196C>T non_coding_transcript_exon_variant 0.16 linezolid
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
aminoglycosides
streptomycin Uncertain significance
rrs 1472042 n.197T>G non_coding_transcript_exon_variant 0.16 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1472053 n.211_212delGC non_coding_transcript_exon_variant 0.15 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1472061 n.216A>T non_coding_transcript_exon_variant 0.14 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1472075 n.230A>G non_coding_transcript_exon_variant 0.13 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1472106 n.261G>A non_coding_transcript_exon_variant 0.13 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.13 linezolid
kanamycin Uncertain significance
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1472150 n.305T>A non_coding_transcript_exon_variant 0.11 linezolid
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
aminoglycosides
streptomycin
rrs 1472251 n.406G>A non_coding_transcript_exon_variant 0.2 linezolid
kanamycin
capreomycin
amikacin Uncertain significance
aminoglycosides
streptomycin
rrs 1472286 n.441C>A non_coding_transcript_exon_variant 0.16 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1472287 n.442C>T non_coding_transcript_exon_variant 0.16 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1472289 n.444T>G non_coding_transcript_exon_variant 0.16 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1472290 n.445C>G non_coding_transcript_exon_variant 0.16 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1472297 n.453_465delGTCCGGGTTCTCT non_coding_transcript_exon_variant 0.18 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1472315 n.470T>G non_coding_transcript_exon_variant 0.17 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1472324 n.479G>C non_coding_transcript_exon_variant 0.16 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1472325 n.480G>C non_coding_transcript_exon_variant 0.16 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1472327 n.482G>A non_coding_transcript_exon_variant 0.15 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1472328 n.483G>T non_coding_transcript_exon_variant 0.15 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1472337 n.492C>G non_coding_transcript_exon_variant 0.15 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1472380 n.535G>C non_coding_transcript_exon_variant 0.17 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1472446 n.601T>A non_coding_transcript_exon_variant 0.11 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1472452 n.607G>A non_coding_transcript_exon_variant 0.11 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1472464 n.619A>G non_coding_transcript_exon_variant 0.14 linezolid
kanamycin
capreomycin
amikacin Uncertain significance
aminoglycosides
streptomycin
rrs 1472846 n.1001C>A non_coding_transcript_exon_variant 0.1 linezolid
kanamycin
capreomycin
amikacin Uncertain significance
aminoglycosides
streptomycin
rrs 1472847 n.1002G>C non_coding_transcript_exon_variant 0.1 linezolid
kanamycin
capreomycin
amikacin Uncertain significance
aminoglycosides
streptomycin
rrs 1472849 n.1004C>G non_coding_transcript_exon_variant 0.1 linezolid
kanamycin
capreomycin
amikacin Uncertain significance
aminoglycosides
streptomycin
rrs 1472850 n.1005T>C non_coding_transcript_exon_variant 0.1 linezolid
kanamycin
capreomycin
amikacin Uncertain significance
aminoglycosides
streptomycin Uncertain significance
rrs 1472857 n.1012A>G non_coding_transcript_exon_variant 0.11 linezolid
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
aminoglycosides
streptomycin Uncertain significance
rrs 1472858 n.1013G>T non_coding_transcript_exon_variant 0.11 linezolid
kanamycin
capreomycin
amikacin Uncertain significance
aminoglycosides
streptomycin Uncertain significance
rrs 1472860 n.1015C>G non_coding_transcript_exon_variant 0.11 linezolid
kanamycin
capreomycin
amikacin Uncertain significance
aminoglycosides
streptomycin
rrs 1472861 n.1016G>T non_coding_transcript_exon_variant 0.11 linezolid
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
aminoglycosides
streptomycin Uncertain significance
rrs 1472973 n.1128A>T non_coding_transcript_exon_variant 0.16 linezolid
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
aminoglycosides
streptomycin
rrs 1473104 n.1259C>T non_coding_transcript_exon_variant 0.13 linezolid
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
aminoglycosides
streptomycin
rrs 1473110 n.1265T>G non_coding_transcript_exon_variant 0.12 linezolid
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
aminoglycosides
streptomycin
rrs 1473111 n.1266A>G non_coding_transcript_exon_variant 0.12 linezolid
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
aminoglycosides
streptomycin
rrl 1474135 n.478G>A non_coding_transcript_exon_variant 0.11 linezolid
rrl 1474140 n.483C>T non_coding_transcript_exon_variant 0.12 linezolid
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.12 linezolid
rrl 1474174 n.517A>G non_coding_transcript_exon_variant 0.12 linezolid
rrl 1474181 n.524C>T non_coding_transcript_exon_variant 0.12 linezolid
rrl 1474183 n.526T>C non_coding_transcript_exon_variant 0.12 linezolid
rrl 1474185 n.528G>A non_coding_transcript_exon_variant 0.12 linezolid
rrl 1474186 n.529A>G non_coding_transcript_exon_variant 0.12 linezolid
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 0.14 linezolid
rrl 1474266 n.609T>C non_coding_transcript_exon_variant 0.11 linezolid
rrl 1474269 n.612C>T non_coding_transcript_exon_variant 0.11 linezolid Uncertain significance
rrl 1474362 n.705A>G non_coding_transcript_exon_variant 0.14 linezolid
rrl 1474676 n.1019T>A non_coding_transcript_exon_variant 0.1 linezolid
rrl 1474760 n.1103A>G non_coding_transcript_exon_variant 0.1 linezolid
rrl 1475647 n.1990G>C non_coding_transcript_exon_variant 0.11 linezolid
rrl 1475659 n.2002G>A non_coding_transcript_exon_variant 0.11 linezolid
rrl 1475753 n.2096C>T non_coding_transcript_exon_variant 0.18 linezolid
rrl 1475762 n.2105G>T non_coding_transcript_exon_variant 0.17 linezolid
rrl 1475763 n.2106C>T non_coding_transcript_exon_variant 0.17 linezolid
rrl 1475764 n.2107A>C non_coding_transcript_exon_variant 0.17 linezolid
rrl 1475765 n.2108A>G non_coding_transcript_exon_variant 0.17 linezolid
rrl 1475775 n.2118G>A non_coding_transcript_exon_variant 0.17 linezolid
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.17 linezolid Uncertain significance
rrl 1475991 n.2334T>C non_coding_transcript_exon_variant 0.17 linezolid
rrl 1475995 n.2338G>A non_coding_transcript_exon_variant 0.16 linezolid
rrl 1476030 n.2373A>G non_coding_transcript_exon_variant 0.11 linezolid
rrl 1476032 n.2375C>A non_coding_transcript_exon_variant 0.12 linezolid
rrl 1476033 n.2376T>G non_coding_transcript_exon_variant 0.12 linezolid
rrl 1476035 n.2378G>C non_coding_transcript_exon_variant 0.12 linezolid
rrl 1476044 n.2387T>G non_coding_transcript_exon_variant 0.11 linezolid
rrl 1476046 n.2389G>T non_coding_transcript_exon_variant 0.11 linezolid
rrl 1476047 n.2390G>T non_coding_transcript_exon_variant 0.13 linezolid
rrl 1476049 n.2392C>T non_coding_transcript_exon_variant 0.15 linezolid
rrl 1476088 n.2431A>C non_coding_transcript_exon_variant 0.19 linezolid
rrl 1476099 n.2442A>G non_coding_transcript_exon_variant 0.17 linezolid
rrl 1476103 n.2446C>G non_coding_transcript_exon_variant 0.15 linezolid
rrl 1476105 n.2448G>A non_coding_transcript_exon_variant 0.15 linezolid
rrl 1476106 n.2449A>T non_coding_transcript_exon_variant 0.15 linezolid
rrl 1476110 n.2453G>C non_coding_transcript_exon_variant 0.16 linezolid
rrl 1476115 n.2458T>C non_coding_transcript_exon_variant 0.14 linezolid
rrl 1476131 n.2474C>T non_coding_transcript_exon_variant 0.14 linezolid
rrl 1476160 n.2503T>C non_coding_transcript_exon_variant 0.16 linezolid
rrl 1476214 n.2557G>T non_coding_transcript_exon_variant 0.18 linezolid
rrl 1476215 n.2558C>T non_coding_transcript_exon_variant 0.18 linezolid
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.2 linezolid
rrl 1476251 n.2594T>G non_coding_transcript_exon_variant 0.23 linezolid
rrl 1476256 n.2599A>T non_coding_transcript_exon_variant 0.22 linezolid
rrl 1476260 n.2603A>G non_coding_transcript_exon_variant 0.21 linezolid Uncertain significance
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.23 linezolid
rrl 1476297 n.2640C>T non_coding_transcript_exon_variant 0.23 linezolid
rrl 1476299 n.2642C>T non_coding_transcript_exon_variant 0.23 linezolid Uncertain significance
rrl 1476529 n.2872A>G non_coding_transcript_exon_variant 0.16 linezolid
rrl 1476540 n.2883C>T non_coding_transcript_exon_variant 0.13 linezolid
rrl 1476597 n.2940G>A non_coding_transcript_exon_variant 0.1 linezolid
rrl 1476603 n.2946G>A non_coding_transcript_exon_variant 0.12 linezolid
rpsA 1833760 c.219C>T synonymous_variant 0.13 pyrazinamide
rpsA 1833787 c.246C>G synonymous_variant 0.12 pyrazinamide
rpsA 1833790 c.249T>C synonymous_variant 0.13 pyrazinamide
rpsA 1833793 c.252C>T synonymous_variant 0.13 pyrazinamide
rpsA 1833802 c.261A>G synonymous_variant 0.16 pyrazinamide
rpsA 1833808 c.267G>C synonymous_variant 0.14 pyrazinamide
rpsA 1833811 c.270G>T synonymous_variant 0.14 pyrazinamide
rpsA 1833829 c.288A>G synonymous_variant 0.16 pyrazinamide
rpsA 1833832 c.291G>A synonymous_variant 0.14 pyrazinamide
rpsA 1833838 c.297G>C synonymous_variant 0.15 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.15 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.15 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.18 pyrazinamide
rpsA 1833862 c.321G>T synonymous_variant 0.18 pyrazinamide
rpsA 1833894 p.Ala118Glu missense_variant 0.16 pyrazinamide
rpsA 1833904 c.363G>A synonymous_variant 0.18 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.15 pyrazinamide
rpsA 1833949 c.408T>C synonymous_variant 0.17 pyrazinamide
rpsA 1833970 c.429G>T synonymous_variant 0.17 pyrazinamide
rpsA 1833976 c.435C>T synonymous_variant 0.15 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.15 pyrazinamide
rpsA 1833991 c.450C>A synonymous_variant 0.14 pyrazinamide
rpsA 1834009 c.468C>T synonymous_variant 0.12 pyrazinamide
rpsA 1834012 c.471G>T synonymous_variant 0.13 pyrazinamide
rpsA 1834015 c.474G>C synonymous_variant 0.13 pyrazinamide
rpsA 1834021 c.480C>T synonymous_variant 0.16 pyrazinamide
rpsA 1834030 c.489C>G synonymous_variant 0.15 pyrazinamide
rpsA 1834234 c.693G>C synonymous_variant 0.1 pyrazinamide
rpsA 1834240 c.699T>C synonymous_variant 0.1 pyrazinamide
rpsA 1834252 c.711C>G synonymous_variant 0.12 pyrazinamide
rpsA 1834261 c.720A>G synonymous_variant 0.14 pyrazinamide
rpsA 1834264 c.723G>C synonymous_variant 0.12 pyrazinamide
rpsA 1834279 c.738C>T synonymous_variant 0.15 pyrazinamide
rpsA 1834297 c.756C>T synonymous_variant 0.2 pyrazinamide
rpsA 1834303 c.762T>G synonymous_variant 0.21 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.21 pyrazinamide
rpsA 1834345 c.804C>T synonymous_variant 0.18 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 0.19 pyrazinamide
rpsA 1834361 c.820T>C synonymous_variant 0.19 pyrazinamide
rpsA 1834366 c.825A>G synonymous_variant 0.2 pyrazinamide
rpsA 1834396 c.855G>C synonymous_variant 0.21 pyrazinamide
rpsA 1834411 c.870T>C synonymous_variant 0.17 pyrazinamide
rpsA 1834423 c.882G>T synonymous_variant 0.18 pyrazinamide
rpsA 1834451 c.910T>C synonymous_variant 0.16 pyrazinamide
rpsA 1834456 c.915T>G synonymous_variant 0.21 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.21 pyrazinamide
rpsA 1834489 c.948T>C synonymous_variant 0.12 pyrazinamide
rpsA 1834520 p.Ala327Ser missense_variant 0.1 pyrazinamide
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 clofazimine Uncertain significance
bedaquiline Uncertain significance
rpoA 3877686 c.822A>G synonymous_variant 0.12 rifampicin
rpoA 3877695 c.813C>G synonymous_variant 0.14 rifampicin
rpoA 3877704 c.804G>T synonymous_variant 0.11 rifampicin
rpoA 3877728 c.780C>G synonymous_variant 0.15 rifampicin
rpoA 3877731 c.777G>T synonymous_variant 0.15 rifampicin
rpoA 3877734 c.774G>C synonymous_variant 0.15 rifampicin
rpoA 3877737 c.771G>C synonymous_variant 0.15 rifampicin
rpoA 3877743 c.765T>C synonymous_variant 0.16 rifampicin
rpoA 3877749 c.759C>T synonymous_variant 0.16 rifampicin
rpoA 3877764 c.744C>G synonymous_variant 0.15 rifampicin
rpoA 3877776 c.732T>C synonymous_variant 0.15 rifampicin
rpoA 3877782 c.726T>C synonymous_variant 0.16 rifampicin
rpoA 3877785 c.723C>A synonymous_variant 0.16 rifampicin
rpoA 3877818 c.690A>G synonymous_variant 0.19 rifampicin
rpoA 3877848 c.660C>T synonymous_variant 0.22 rifampicin
rpoA 3877856 c.652T>C synonymous_variant 0.22 rifampicin
rpoA 3877857 c.651G>A synonymous_variant 0.22 rifampicin
rpoA 3877866 c.642G>C synonymous_variant 0.2 rifampicin
rpoA 3877875 c.633T>A synonymous_variant 0.2 rifampicin
rpoA 3877878 c.630G>C synonymous_variant 0.2 rifampicin
rpoA 3877887 c.621G>C synonymous_variant 0.21 rifampicin
rpoA 3877893 c.615C>T synonymous_variant 0.17 rifampicin
rpoA 3877905 c.603A>G synonymous_variant 0.17 rifampicin
rpoA 3877908 c.600T>C synonymous_variant 0.17 rifampicin
rpoA 3877920 c.588G>C synonymous_variant 0.16 rifampicin
rpoA 3877926 c.582G>C synonymous_variant 0.17 rifampicin
rpoA 3877962 c.546G>T synonymous_variant 0.16 rifampicin
rpoA 3877971 p.Asp179Glu missense_variant 0.15 rifampicin
clpC1 4038878 c.1827A>G synonymous_variant 0.12 pyrazinamide
clpC1 4039274 c.1431G>C synonymous_variant 0.11 pyrazinamide
clpC1 4039286 c.1419T>C synonymous_variant 0.11 pyrazinamide
clpC1 4039295 c.1410A>C synonymous_variant 0.12 pyrazinamide
clpC1 4039298 c.1407T>C synonymous_variant 0.12 pyrazinamide
clpC1 4039310 c.1395A>G synonymous_variant 0.11 pyrazinamide
clpC1 4039313 c.1392C>G synonymous_variant 0.11 pyrazinamide
clpC1 4039320 p.Ala462Gly missense_variant 0.12 pyrazinamide
clpC1 4039322 c.1383T>C synonymous_variant 0.12 pyrazinamide
clpC1 4039328 c.1377A>C synonymous_variant 0.12 pyrazinamide
clpC1 4039337 p.Thr456Gln missense_variant 0.11 pyrazinamide
clpC1 4039352 c.1353C>T synonymous_variant 0.14 pyrazinamide
clpC1 4039361 c.1344C>G synonymous_variant 0.11 pyrazinamide
clpC1 4039409 c.1296T>C synonymous_variant 0.11 pyrazinamide
clpC1 4039412 c.1293T>G synonymous_variant 0.11 pyrazinamide
clpC1 4039670 c.1035G>C synonymous_variant 0.12 pyrazinamide
clpC1 4039682 c.1023C>G synonymous_variant 0.15 pyrazinamide
clpC1 4039694 c.1011G>C synonymous_variant 0.14 pyrazinamide
clpC1 4039724 c.981A>G synonymous_variant 0.13 pyrazinamide
clpC1 4039733 c.972G>C synonymous_variant 0.11 pyrazinamide
clpC1 4039742 c.963C>T synonymous_variant 0.11 pyrazinamide
clpC1 4039760 c.945T>C synonymous_variant 0.12 pyrazinamide
clpC1 4039769 c.936C>G synonymous_variant 0.12 pyrazinamide
clpC1 4039883 c.822G>A synonymous_variant 0.15 pyrazinamide
clpC1 4039889 c.816G>C synonymous_variant 0.14 pyrazinamide
clpC1 4039898 c.807C>G synonymous_variant 0.14 pyrazinamide
clpC1 4039904 c.801A>G synonymous_variant 0.14 pyrazinamide
clpC1 4039931 c.774T>C synonymous_variant 0.12 pyrazinamide
clpC1 4039934 c.771G>A synonymous_variant 0.12 pyrazinamide
clpC1 4039937 c.768G>C synonymous_variant 0.12 pyrazinamide
clpC1 4039946 c.759A>T synonymous_variant 0.12 pyrazinamide
clpC1 4039949 c.756G>C synonymous_variant 0.12 pyrazinamide
clpC1 4039952 c.753T>C synonymous_variant 0.12 pyrazinamide
clpC1 4039958 c.747G>C synonymous_variant 0.12 pyrazinamide
clpC1 4039991 c.714G>C synonymous_variant 0.11 pyrazinamide
clpC1 4040003 c.702G>C synonymous_variant 0.1 pyrazinamide
clpC1 4040021 c.684A>C synonymous_variant 0.11 pyrazinamide
clpC1 4040024 c.681A>G synonymous_variant 0.11 pyrazinamide
clpC1 4040033 c.672G>C synonymous_variant 0.13 pyrazinamide
clpC1 4040249 c.456A>G synonymous_variant 0.1 pyrazinamide
clpC1 4040279 c.426C>G synonymous_variant 0.11 pyrazinamide
embB 4248112 c.1599C>G synonymous_variant 0.14 ethambutol
embB 4248118 c.1605T>C synonymous_variant 0.13 ethambutol
embB 4248130 c.1617G>C synonymous_variant 0.12 ethambutol
embB 4248133 c.1620C>G synonymous_variant 0.12 ethambutol
embB 4248142 c.1629T>C synonymous_variant 0.12 ethambutol
embB 4248143 p.Leu544Ile missense_variant 0.12 ethambutol
embB 4248157 c.1644A>G synonymous_variant 0.13 ethambutol
embB 4248158 p.Cys549Ser missense_variant 0.13 ethambutol
embB 4248167 p.Thr552Ala missense_variant 0.16 ethambutol
embB 4248170 p.Ala553Ser missense_variant 0.16 ethambutol
embB 4248173 p.Val554Leu missense_variant 0.16 ethambutol
embB 4248199 c.1686A>G synonymous_variant 0.13 ethambutol
embB 4248200 p.Ile563Val missense_variant 0.13 ethambutol
embB 4248205 c.1692C>G synonymous_variant 0.13 ethambutol
embB 4248206 p.Ser565Gly missense_variant 0.13 ethambutol Uncertain significance
embB 4248220 c.1707A>G synonymous_variant 0.14 ethambutol
embB 4248225 p.Ala571Val missense_variant 0.14 ethambutol
embB 4248233 c.1720C>T synonymous_variant 0.12 ethambutol
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 streptomycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance