TB-Profiler

TB-Profiler result

Run: ERR978760

This average coverage of the target regions is below the recommended 30x. Some mutations may not be detected due to low coverage.

Summary

Run ID: ERR978760

Sample name:

Date: 2024-10-04T02:11:26.613860

Number of reads: 760421

Percentage reads mapped: 16.39

Median coverage: 22.0

Strain: lineage4.8

Spoligotype:

Drug-resistance: RR-TB

Download CSV Download TXT Download JSON

Lineage Table: The lineage is inferred by analysing lineage specific SNPs

Lineage	Family	RDs	Frequency
lineage4	Euro-American	None	1.0
lineage4.8	Euro-American (mainly T)	RD219	1.0

Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes

Drug	Resistance	Supporting mutations	WHO confidence	Comment
rifampicin	rpoB	p.Ser441Ala	Assoc w R - Interim	Expert rule: Non-silent variants in RRDR of rpoB
rifampicin	rpoB	p.Gly442Glu	Assoc w R - Interim	Expert rule: Non-silent variants in RRDR of rpoB
p.Leu443Met	Assoc w R - Interim	Expert rule: Non-silent variants in RRDR of rpoB
isoniazid
ethambutol
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin	rrs	n.1402C>A	Uncertain significance	Mutation from literature
amikacin	rrs	n.1484G>T	Assoc w R
capreomycin	rrs	n.1402C>A	Uncertain significance	Mutation from literature
capreomycin	rrs	n.1484G>T	Assoc w R
kanamycin	rrs	n.1402C>A	Uncertain significance	Mutation from literature
kanamycin	rrs	n.1484G>T	Assoc w R
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid

Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance

Gene	Chromosome position	Mutation	Type	Estimated fraction	Drugs	Confidence	Comment
rpoB	761127	p.Ser441Ala	missense_variant	0.36	rifampicin	Assoc w R - Interim	Expert rule: Non-silent variants in RRDR of rpoB
rpoB	761131	p.Gly442Glu	missense_variant	0.37	rifampicin	Assoc w R - Interim	Expert rule: Non-silent variants in RRDR of rpoB
rpoB	761133	p.Leu443Met	missense_variant	0.37	rifampicin	Assoc w R - Interim	Expert rule: Non-silent variants in RRDR of rpoB
rrs	1473247	n.1402C>A	non_coding_transcript_exon_variant	0.88	amikacin	Uncertain significance	Mutation from literature
					capreomycin	Uncertain significance	Mutation from literature
					kanamycin	Uncertain significance	Mutation from literature
rrs	1473329	n.1484G>T	non_coding_transcript_exon_variant	0.83	amikacin	Assoc w R
					capreomycin	Assoc w R
					kanamycin	Assoc w R

Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance

Gene	Chromosome position	Mutation	Type	Estimated fraction	Drugs	Confidence
gyrA	7362	p.Glu21Gln	missense_variant	1.0	levofloxacin	Not assoc w R
gyrA	7362	p.Glu21Gln	missense_variant	1.0	moxifloxacin	Not assoc w R
Rv0565c	656265	c.1204_1205delAC	frameshift_variant	1.0	ethionamide	Uncertain significance
nusG	734658	c.405A>G	synonymous_variant	0.94	rifampicin	Not assoc w R
rpoB	761063	c.1257C>G	synonymous_variant	0.28	rifampicin	Not assoc w R - Interim
rpoB	761084	c.1278C>A	synonymous_variant	0.3	rifampicin	Not assoc w R - Interim
rpoB	761088	c.1282_1283delAGinsTC	synonymous_variant	0.31	rifampicin
rpoB	761097	c.1291_1293delAGCinsTCG	synonymous_variant	0.32	rifampicin
rpoB	761102	c.1296A>G	synonymous_variant	0.32	rifampicin
rpoB	761111	c.1305C>T	synonymous_variant	0.43	rifampicin	Not assoc w R - Interim
rpoB	761147	c.1341C>T	synonymous_variant	0.41	rifampicin	Not assoc w R - Interim
rpoB	761150	c.1344A>C	synonymous_variant	0.4	rifampicin	Not assoc w R - Interim
rpoB	761159	c.1353G>C	synonymous_variant	0.35	rifampicin	Not assoc w R - Interim
rpoB	761160	c.1354C>T	synonymous_variant	0.33	rifampicin	Not assoc w R - Interim
rpoB	761165	c.1359G>C	synonymous_variant	0.33	rifampicin	Not assoc w R - Interim
rpoB	762879	p.Met1025Leu	missense_variant	0.45	rifampicin	Uncertain significance
rpoC	762899	c.-471G>T	upstream_gene_variant	0.44	rifampicin
rpoB	762920	c.3114C>T	synonymous_variant	0.46	rifampicin	Not assoc w R - Interim
rpoB	762929	c.3123G>C	synonymous_variant	0.47	rifampicin	Not assoc w R - Interim
rpoC	762959	c.-411G>T	upstream_gene_variant	0.52	rifampicin
rpoC	762971	c.-399G>C	upstream_gene_variant	0.47	rifampicin
rpoC	762983	c.-387C>T	upstream_gene_variant	0.46	rifampicin
rpoB	762989	c.3183G>A	synonymous_variant	0.47	rifampicin	Not assoc w R - Interim
rpoB	762995	c.3189G>T	synonymous_variant	0.45	rifampicin	Not assoc w R - Interim
rpoB	763002	c.3197dupA	frameshift_variant	0.41	rifampicin
rpoB	763006	c.3201delC	frameshift_variant	0.39	rifampicin
rpoB	763017	p.Gln1071Glu	missense_variant	0.31	rifampicin
rpoC	763528	c.159G>A	synonymous_variant	0.53	rifampicin	Not assoc w R - Interim
rpoC	763534	c.165T>C	synonymous_variant	0.55	rifampicin
rpoC	763537	c.168C>G	synonymous_variant	0.53	rifampicin
rpoC	763546	c.177A>G	synonymous_variant	0.5	rifampicin	Not assoc w R - Interim
rpoC	763570	c.201G>C	synonymous_variant	0.5	rifampicin	Not assoc w R - Interim
rpoC	763573	c.204G>C	synonymous_variant	0.5	rifampicin	Not assoc w R - Interim
rpoC	763594	c.225C>T	synonymous_variant	0.48	rifampicin	Not assoc w R - Interim
rpoC	763622	p.Ala85Ser	missense_variant	0.44	rifampicin	Uncertain significance
rpoC	763627	p.Lys86Asn	missense_variant	0.4	rifampicin	Uncertain significance
rpoC	763642	c.273G>T	synonymous_variant	0.42	rifampicin
mmpL5	775639	p.Ile948Val	missense_variant	1.0	bedaquiline	Not assoc w R - Interim
mmpL5	775639	p.Ile948Val	missense_variant	1.0	clofazimine	Not assoc w R
rpsL	781275	c.-285A>C	upstream_gene_variant	1.0	streptomycin
rpsL	781395	c.-165T>C	upstream_gene_variant	1.0	streptomycin	Not assoc w R
rrs	1471659	n.-187C>T	upstream_gene_variant	1.0	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1471923	n.78delTinsCCCTG	non_coding_transcript_exon_variant	0.35	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1471926	n.81C>T	non_coding_transcript_exon_variant	0.35	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1471929	n.84C>G	non_coding_transcript_exon_variant	0.33	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1471930	n.85G>T	non_coding_transcript_exon_variant	0.33	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1471932	n.87A>G	non_coding_transcript_exon_variant	0.33	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1471934	n.89A>G	non_coding_transcript_exon_variant	0.33	kanamycin
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1471936	n.91A>G	non_coding_transcript_exon_variant	0.33	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1471967	n.122G>A	non_coding_transcript_exon_variant	0.31	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1471970	n.125G>A	non_coding_transcript_exon_variant	0.31	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1471972	n.127T>C	non_coding_transcript_exon_variant	0.32	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1471980	n.135G>T	non_coding_transcript_exon_variant	0.3	kanamycin
					capreomycin
					streptomycin	Uncertain significance
					amikacin
rrs	1471981	n.136C>G	non_coding_transcript_exon_variant	0.3	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1471986	n.141C>T	non_coding_transcript_exon_variant	0.28	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1471993	n.149_150delGC	non_coding_transcript_exon_variant	0.31	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1471998	n.153delGinsTCA	non_coding_transcript_exon_variant	0.32	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1472009	n.164T>G	non_coding_transcript_exon_variant	0.3	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1472085	n.240C>T	non_coding_transcript_exon_variant	0.45	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1472106	n.261G>A	non_coding_transcript_exon_variant	0.57	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1472107	n.262A>G	non_coding_transcript_exon_variant	0.57	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin
					amikacin	Uncertain significance
rrs	1472108	n.263C>T	non_coding_transcript_exon_variant	0.59	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472112	n.267C>T	non_coding_transcript_exon_variant	0.61	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472122	n.277G>T	non_coding_transcript_exon_variant	0.67	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1472123	n.278A>T	non_coding_transcript_exon_variant	0.67	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1472124	n.279C>T	non_coding_transcript_exon_variant	0.67	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin
					amikacin	Uncertain significance
rrs	1472150	n.305T>A	non_coding_transcript_exon_variant	0.85	kanamycin	Uncertain significance
					capreomycin	Not assoc w R
					streptomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1472160	n.315C>T	non_coding_transcript_exon_variant	0.86	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472225	n.380C>G	non_coding_transcript_exon_variant	0.87	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1472240	n.395G>A	non_coding_transcript_exon_variant	0.84	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472251	n.406G>C	non_coding_transcript_exon_variant	0.83	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1472279	n.434T>G	non_coding_transcript_exon_variant	0.68	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1472285	n.440A>G	non_coding_transcript_exon_variant	0.62	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472288	n.443A>T	non_coding_transcript_exon_variant	0.38	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1472289	n.444T>G	non_coding_transcript_exon_variant	0.38	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472290	n.445C>T	non_coding_transcript_exon_variant	0.38	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin
					amikacin	Uncertain significance
rrs	1472298	n.453_467delGTCCGGGTTCTCTCGinsCGT	non_coding_transcript_exon_variant	0.38	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1472315	n.470T>G	non_coding_transcript_exon_variant	0.37	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin
					amikacin	Uncertain significance
rrs	1472324	n.479G>A	non_coding_transcript_exon_variant	0.37	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1472325	n.480G>T	non_coding_transcript_exon_variant	0.37	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1472326	n.481T>G	non_coding_transcript_exon_variant	0.37	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1472329	n.484A>T	non_coding_transcript_exon_variant	0.37	kanamycin
					capreomycin
					streptomycin	Uncertain significance
					amikacin
rrs	1472330	n.485G>A	non_coding_transcript_exon_variant	0.37	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1472344	n.499C>T	non_coding_transcript_exon_variant	0.43	kanamycin	Uncertain significance
					capreomycin	Not assoc w R
					streptomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1472368	n.523A>G	non_coding_transcript_exon_variant	0.47	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1472507	n.662C>A	non_coding_transcript_exon_variant	0.71	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1472522	n.677T>G	non_coding_transcript_exon_variant	0.82	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1472557	n.712G>A	non_coding_transcript_exon_variant	0.82	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472571	n.726G>T	non_coding_transcript_exon_variant	0.83	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1472581	n.736A>C	non_coding_transcript_exon_variant	0.84	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472582	n.737G>T	non_coding_transcript_exon_variant	0.84	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1472584	n.739A>T	non_coding_transcript_exon_variant	0.83	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472585	n.740A>C	non_coding_transcript_exon_variant	0.83	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1472623	n.778A>C	non_coding_transcript_exon_variant	0.9	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1472647	n.802C>T	non_coding_transcript_exon_variant	0.93	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1472673	n.828T>G	non_coding_transcript_exon_variant	0.92	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1472675	n.830T>C	non_coding_transcript_exon_variant	0.92	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin
					amikacin	Uncertain significance
rrs	1472677	n.832C>A	non_coding_transcript_exon_variant	0.92	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin
					amikacin	Uncertain significance
rrs	1472682	n.837T>A	non_coding_transcript_exon_variant	0.92	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472683	n.838T>C	non_coding_transcript_exon_variant	0.91	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472687	n.842A>T	non_coding_transcript_exon_variant	0.93	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin
					amikacin	Uncertain significance
rrs	1472707	n.862A>T	non_coding_transcript_exon_variant	0.93	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1472767	n.922G>C	non_coding_transcript_exon_variant	0.85	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1472790	n.945T>C	non_coding_transcript_exon_variant	0.8	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472812	n.967A>T	non_coding_transcript_exon_variant	0.53	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1472954	n.1110delC	non_coding_transcript_exon_variant	0.86	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1472958	n.1113_1114insC	non_coding_transcript_exon_variant	0.87	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1472973	n.1128A>T	non_coding_transcript_exon_variant	0.86	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin
					amikacin	Uncertain significance
rrs	1472986	n.1141_1142insA	non_coding_transcript_exon_variant	0.87	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1472989	n.1145delA	non_coding_transcript_exon_variant	0.87	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1472996	n.1151T>C	non_coding_transcript_exon_variant	0.87	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473066	n.1221A>G	non_coding_transcript_exon_variant	0.86	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473081	n.1236C>T	non_coding_transcript_exon_variant	0.78	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473088	n.1243A>G	non_coding_transcript_exon_variant	0.71	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473091	n.1246G>A	non_coding_transcript_exon_variant	0.62	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473093	n.1248C>T	non_coding_transcript_exon_variant	0.64	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473094	n.1249T>G	non_coding_transcript_exon_variant	0.64	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1473099	n.1254T>G	non_coding_transcript_exon_variant	0.66	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473100	n.1255G>C	non_coding_transcript_exon_variant	0.66	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1473102	n.1257C>T	non_coding_transcript_exon_variant	0.66	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473104	n.1259C>T	non_coding_transcript_exon_variant	0.66	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473109	n.1264T>G	non_coding_transcript_exon_variant	0.66	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1473111	n.1266A>G	non_coding_transcript_exon_variant	0.67	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473120	n.1275C>T	non_coding_transcript_exon_variant	0.73	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473121	n.1276T>C	non_coding_transcript_exon_variant	0.73	kanamycin	Uncertain significance
					capreomycin	Not assoc w R
					streptomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1473122	n.1277T>G	non_coding_transcript_exon_variant	0.74	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1473123	n.1278A>G	non_coding_transcript_exon_variant	0.74	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473145	n.1300C>T	non_coding_transcript_exon_variant	0.81	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473164	n.1319C>T	non_coding_transcript_exon_variant	0.82	kanamycin
					capreomycin
					streptomycin	Uncertain significance
					amikacin
rrs	1473166	n.1321G>A	non_coding_transcript_exon_variant	0.81	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473226	n.1381C>G	non_coding_transcript_exon_variant	0.85	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1473259	n.1414C>T	non_coding_transcript_exon_variant	0.87	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1473276	n.1431A>G	non_coding_transcript_exon_variant	0.85	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473288	n.1443C>G	non_coding_transcript_exon_variant	0.83	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473290	n.1445C>T	non_coding_transcript_exon_variant	0.83	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin
					amikacin	Uncertain significance
rrs	1473292	n.1447G>T	non_coding_transcript_exon_variant	0.84	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1473294	n.1449A>G	non_coding_transcript_exon_variant	0.84	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473301	n.1456T>C	non_coding_transcript_exon_variant	0.85	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473315	n.1470T>C	non_coding_transcript_exon_variant	0.85	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473316	n.1471C>T	non_coding_transcript_exon_variant	0.84	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473319	n.1474C>T	non_coding_transcript_exon_variant	0.84	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473324	n.1479G>A	non_coding_transcript_exon_variant	0.84	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin
					amikacin
rrl	1474184	n.527C>T	non_coding_transcript_exon_variant	0.7	capreomycin	Uncertain significance
rrl	1474184	n.527C>T	non_coding_transcript_exon_variant	0.7	linezolid	Uncertain significance
rrl	1474186	n.529A>G	non_coding_transcript_exon_variant	0.73	capreomycin	Uncertain significance
rrl	1474186	n.529A>G	non_coding_transcript_exon_variant	0.73	linezolid	Uncertain significance
rrl	1474197	n.540C>T	non_coding_transcript_exon_variant	0.78	capreomycin	Uncertain significance
rrl	1474197	n.540C>T	non_coding_transcript_exon_variant	0.78	linezolid
rrl	1474202	n.545T>G	non_coding_transcript_exon_variant	0.75	capreomycin
rrl	1474202	n.545T>G	non_coding_transcript_exon_variant	0.75	linezolid
rrl	1474218	n.561T>G	non_coding_transcript_exon_variant	0.75	capreomycin
rrl	1474218	n.561T>G	non_coding_transcript_exon_variant	0.75	linezolid
rrl	1474253	n.596A>T	non_coding_transcript_exon_variant	0.7	capreomycin	Uncertain significance
rrl	1474253	n.596A>T	non_coding_transcript_exon_variant	0.7	linezolid	Uncertain significance
rrl	1474264	n.607T>G	non_coding_transcript_exon_variant	0.72	capreomycin
rrl	1474264	n.607T>G	non_coding_transcript_exon_variant	0.72	linezolid
rrl	1474265	n.608G>T	non_coding_transcript_exon_variant	0.72	capreomycin
rrl	1474265	n.608G>T	non_coding_transcript_exon_variant	0.72	linezolid
rrl	1474266	n.609T>C	non_coding_transcript_exon_variant	0.72	capreomycin	Uncertain significance
rrl	1474266	n.609T>C	non_coding_transcript_exon_variant	0.72	linezolid	Uncertain significance
rrl	1474269	n.612C>A	non_coding_transcript_exon_variant	0.73	capreomycin
rrl	1474269	n.612C>A	non_coding_transcript_exon_variant	0.73	linezolid
rrl	1474271	n.614A>G	non_coding_transcript_exon_variant	0.75	capreomycin
rrl	1474271	n.614A>G	non_coding_transcript_exon_variant	0.75	linezolid
rrl	1474275	n.618T>G	non_coding_transcript_exon_variant	0.75	capreomycin
rrl	1474275	n.618T>G	non_coding_transcript_exon_variant	0.75	linezolid
rrl	1474287	n.631_649delCCTTTTCCTCTCCGGAGGA	non_coding_transcript_exon_variant	0.79	capreomycin
rrl	1474287	n.631_649delCCTTTTCCTCTCCGGAGGA	non_coding_transcript_exon_variant	0.79	linezolid
rrl	1474308	n.651G>T	non_coding_transcript_exon_variant	0.72	capreomycin	Uncertain significance
rrl	1474308	n.651G>T	non_coding_transcript_exon_variant	0.72	linezolid	Uncertain significance
rrl	1474348	n.691C>T	non_coding_transcript_exon_variant	0.33	capreomycin	Uncertain significance
rrl	1474348	n.691C>T	non_coding_transcript_exon_variant	0.33	linezolid	Uncertain significance
rrl	1474454	n.797G>A	non_coding_transcript_exon_variant	0.61	capreomycin	Uncertain significance
rrl	1474454	n.797G>A	non_coding_transcript_exon_variant	0.61	linezolid	Uncertain significance
rrl	1474467	n.810A>T	non_coding_transcript_exon_variant	0.75	capreomycin
rrl	1474467	n.810A>T	non_coding_transcript_exon_variant	0.75	linezolid
rrl	1474476	n.819C>T	non_coding_transcript_exon_variant	0.84	capreomycin
rrl	1474476	n.819C>T	non_coding_transcript_exon_variant	0.84	linezolid
rrl	1474488	n.831G>A	non_coding_transcript_exon_variant	0.87	capreomycin
rrl	1474488	n.831G>A	non_coding_transcript_exon_variant	0.87	linezolid
rrl	1474496	n.839C>T	non_coding_transcript_exon_variant	0.88	capreomycin
rrl	1474496	n.839C>T	non_coding_transcript_exon_variant	0.88	linezolid
rrl	1474497	n.840G>C	non_coding_transcript_exon_variant	0.88	capreomycin	Uncertain significance
rrl	1474497	n.840G>C	non_coding_transcript_exon_variant	0.88	linezolid	Uncertain significance
rrl	1474506	n.849C>G	non_coding_transcript_exon_variant	0.89	capreomycin	Uncertain significance
rrl	1474506	n.849C>G	non_coding_transcript_exon_variant	0.89	linezolid	Uncertain significance
rrl	1474507	n.850G>T	non_coding_transcript_exon_variant	0.89	capreomycin	Uncertain significance
rrl	1474507	n.850G>T	non_coding_transcript_exon_variant	0.89	linezolid	Uncertain significance
rrl	1474516	n.859C>T	non_coding_transcript_exon_variant	0.9	capreomycin
rrl	1474516	n.859C>T	non_coding_transcript_exon_variant	0.9	linezolid
rrl	1474529	n.872A>C	non_coding_transcript_exon_variant	0.9	capreomycin
rrl	1474529	n.872A>C	non_coding_transcript_exon_variant	0.9	linezolid
rrl	1474530	n.873G>A	non_coding_transcript_exon_variant	0.9	capreomycin
rrl	1474530	n.873G>A	non_coding_transcript_exon_variant	0.9	linezolid
rrl	1474537	n.880G>A	non_coding_transcript_exon_variant	0.88	capreomycin	Uncertain significance
rrl	1474537	n.880G>A	non_coding_transcript_exon_variant	0.88	linezolid	Uncertain significance
rrl	1474539	n.882C>T	non_coding_transcript_exon_variant	0.87	capreomycin
rrl	1474539	n.882C>T	non_coding_transcript_exon_variant	0.87	linezolid
rrl	1474540	n.883T>G	non_coding_transcript_exon_variant	0.89	capreomycin
rrl	1474540	n.883T>G	non_coding_transcript_exon_variant	0.89	linezolid
rrl	1474552	n.895C>T	non_coding_transcript_exon_variant	0.88	capreomycin
rrl	1474552	n.895C>T	non_coding_transcript_exon_variant	0.88	linezolid
rrl	1474558	n.901G>A	non_coding_transcript_exon_variant	0.89	capreomycin	Uncertain significance
rrl	1474558	n.901G>A	non_coding_transcript_exon_variant	0.89	linezolid
rrl	1474582	n.925T>A	non_coding_transcript_exon_variant	0.89	capreomycin
rrl	1474582	n.925T>A	non_coding_transcript_exon_variant	0.89	linezolid
rrl	1474749	n.1092C>T	non_coding_transcript_exon_variant	0.84	capreomycin	Uncertain significance
rrl	1474749	n.1092C>T	non_coding_transcript_exon_variant	0.84	linezolid	Uncertain significance
rrl	1474752	n.1096delA	non_coding_transcript_exon_variant	0.85	capreomycin
rrl	1474752	n.1096delA	non_coding_transcript_exon_variant	0.85	linezolid
rrl	1474760	n.1103A>G	non_coding_transcript_exon_variant	0.87	capreomycin	Uncertain significance
rrl	1474760	n.1103A>G	non_coding_transcript_exon_variant	0.87	linezolid	Uncertain significance
rrl	1474779	n.1122G>A	non_coding_transcript_exon_variant	0.88	capreomycin	Uncertain significance
rrl	1474779	n.1122G>A	non_coding_transcript_exon_variant	0.88	linezolid	Uncertain significance
rrl	1474780	n.1123C>T	non_coding_transcript_exon_variant	0.88	capreomycin	Uncertain significance
rrl	1474780	n.1123C>T	non_coding_transcript_exon_variant	0.88	linezolid	Uncertain significance
rrl	1474782	n.1125G>A	non_coding_transcript_exon_variant	0.9	capreomycin	Not assoc w R
rrl	1474782	n.1125G>A	non_coding_transcript_exon_variant	0.9	linezolid	Uncertain significance
rrl	1474794	n.1137C>T	non_coding_transcript_exon_variant	0.9	capreomycin	Uncertain significance
rrl	1474794	n.1137C>T	non_coding_transcript_exon_variant	0.9	linezolid	Uncertain significance
rrl	1474798	n.1141C>T	non_coding_transcript_exon_variant	0.9	capreomycin	Uncertain significance
rrl	1474798	n.1141C>T	non_coding_transcript_exon_variant	0.9	linezolid	Uncertain significance
rrl	1474799	n.1143delT	non_coding_transcript_exon_variant	0.9	capreomycin
rrl	1474799	n.1143delT	non_coding_transcript_exon_variant	0.9	linezolid
rrl	1474803	n.1146_1147insA	non_coding_transcript_exon_variant	0.9	capreomycin
rrl	1474803	n.1146_1147insA	non_coding_transcript_exon_variant	0.9	linezolid
rrl	1474806	n.1149A>C	non_coding_transcript_exon_variant	0.9	capreomycin
rrl	1474806	n.1149A>C	non_coding_transcript_exon_variant	0.9	linezolid
rrl	1474823	n.1166C>G	non_coding_transcript_exon_variant	0.89	capreomycin	Uncertain significance
rrl	1474823	n.1166C>G	non_coding_transcript_exon_variant	0.89	linezolid	Uncertain significance
rrl	1474827	n.1170C>T	non_coding_transcript_exon_variant	0.89	capreomycin	Uncertain significance
rrl	1474827	n.1170C>T	non_coding_transcript_exon_variant	0.89	linezolid	Uncertain significance
rrl	1474830	n.1173A>G	non_coding_transcript_exon_variant	0.91	capreomycin	Uncertain significance
rrl	1474830	n.1173A>G	non_coding_transcript_exon_variant	0.91	linezolid	Uncertain significance
rrl	1474831	n.1174A>T	non_coding_transcript_exon_variant	0.9	capreomycin	Uncertain significance
rrl	1474831	n.1174A>T	non_coding_transcript_exon_variant	0.9	linezolid	Uncertain significance
rrl	1474853	n.1196A>G	non_coding_transcript_exon_variant	0.91	capreomycin
rrl	1474853	n.1196A>G	non_coding_transcript_exon_variant	0.91	linezolid
rrl	1474864	n.1207C>T	non_coding_transcript_exon_variant	0.93	capreomycin	Not assoc w R
rrl	1474864	n.1207C>T	non_coding_transcript_exon_variant	0.93	linezolid	Uncertain significance
rrl	1474904	n.1247G>C	non_coding_transcript_exon_variant	0.79	capreomycin	Uncertain significance
rrl	1474904	n.1247G>C	non_coding_transcript_exon_variant	0.79	linezolid	Uncertain significance
rrl	1474905	n.1248T>C	non_coding_transcript_exon_variant	0.71	capreomycin	Uncertain significance
rrl	1474905	n.1248T>C	non_coding_transcript_exon_variant	0.71	linezolid	Uncertain significance
rrl	1475673	n.2016T>C	non_coding_transcript_exon_variant	0.76	capreomycin	Uncertain significance
rrl	1475673	n.2016T>C	non_coding_transcript_exon_variant	0.76	linezolid	Uncertain significance
rrl	1475699	n.2042C>T	non_coding_transcript_exon_variant	0.86	capreomycin	Uncertain significance
rrl	1475699	n.2042C>T	non_coding_transcript_exon_variant	0.86	linezolid	Uncertain significance
rrl	1475722	n.2065G>T	non_coding_transcript_exon_variant	0.92	capreomycin
rrl	1475722	n.2065G>T	non_coding_transcript_exon_variant	0.92	linezolid
rrl	1475747	n.2090A>G	non_coding_transcript_exon_variant	0.88	capreomycin	Uncertain significance
rrl	1475747	n.2090A>G	non_coding_transcript_exon_variant	0.88	linezolid	Uncertain significance
rrl	1475751	n.2094C>A	non_coding_transcript_exon_variant	0.88	capreomycin
rrl	1475751	n.2094C>A	non_coding_transcript_exon_variant	0.88	linezolid
rrl	1475753	n.2096C>T	non_coding_transcript_exon_variant	0.87	capreomycin	Uncertain significance
rrl	1475753	n.2096C>T	non_coding_transcript_exon_variant	0.87	linezolid
rrl	1475756	n.2099_2107delTAACCCGCAinsG	non_coding_transcript_exon_variant	0.88	capreomycin
rrl	1475756	n.2099_2107delTAACCCGCAinsG	non_coding_transcript_exon_variant	0.88	linezolid
rrl	1475767	n.2110G>T	non_coding_transcript_exon_variant	0.88	capreomycin
rrl	1475767	n.2110G>T	non_coding_transcript_exon_variant	0.88	linezolid	Uncertain significance
rrl	1475770	n.2113_2114delGAinsATGCGT	non_coding_transcript_exon_variant	0.88	capreomycin
rrl	1475770	n.2113_2114delGAinsATGCGT	non_coding_transcript_exon_variant	0.88	linezolid
rrl	1475777	n.2120A>T	non_coding_transcript_exon_variant	0.88	capreomycin
rrl	1475777	n.2120A>T	non_coding_transcript_exon_variant	0.88	linezolid
rrl	1475781	n.2124T>C	non_coding_transcript_exon_variant	0.89	capreomycin	Uncertain significance
rrl	1475781	n.2124T>C	non_coding_transcript_exon_variant	0.89	linezolid
rrl	1475869	n.2212C>A	non_coding_transcript_exon_variant	0.91	capreomycin
rrl	1475869	n.2212C>A	non_coding_transcript_exon_variant	0.91	linezolid
rrl	1475877	n.2220C>T	non_coding_transcript_exon_variant	0.91	capreomycin	Uncertain significance
rrl	1475877	n.2220C>T	non_coding_transcript_exon_variant	0.91	linezolid
rrl	1475881	n.2224T>C	non_coding_transcript_exon_variant	0.9	capreomycin
rrl	1475881	n.2224T>C	non_coding_transcript_exon_variant	0.9	linezolid
rrl	1475883	n.2226A>T	non_coding_transcript_exon_variant	0.91	capreomycin	Uncertain significance
rrl	1475883	n.2226A>T	non_coding_transcript_exon_variant	0.91	linezolid	Uncertain significance
rrl	1475892	n.2235A>C	non_coding_transcript_exon_variant	0.91	capreomycin
rrl	1475892	n.2235A>C	non_coding_transcript_exon_variant	0.91	linezolid
rrl	1475898	n.2241A>G	non_coding_transcript_exon_variant	0.91	capreomycin	Uncertain significance
rrl	1475898	n.2241A>G	non_coding_transcript_exon_variant	0.91	linezolid
rrl	1475899	n.2242G>A	non_coding_transcript_exon_variant	0.91	capreomycin	Uncertain significance
rrl	1475899	n.2242G>A	non_coding_transcript_exon_variant	0.91	linezolid
rrl	1475906	n.2249C>T	non_coding_transcript_exon_variant	0.91	capreomycin	Uncertain significance
rrl	1475906	n.2249C>T	non_coding_transcript_exon_variant	0.91	linezolid	Uncertain significance
rrl	1475916	n.2259C>T	non_coding_transcript_exon_variant	0.92	capreomycin	Uncertain significance
rrl	1475916	n.2259C>T	non_coding_transcript_exon_variant	0.92	linezolid	Uncertain significance
rrl	1475943	n.2286G>A	non_coding_transcript_exon_variant	0.92	capreomycin	Uncertain significance
rrl	1475943	n.2286G>A	non_coding_transcript_exon_variant	0.92	linezolid	Uncertain significance
rrl	1475952	n.2295A>G	non_coding_transcript_exon_variant	0.92	capreomycin	Uncertain significance
rrl	1475952	n.2295A>G	non_coding_transcript_exon_variant	0.92	linezolid	Uncertain significance
rrl	1475970	n.2313C>T	non_coding_transcript_exon_variant	0.87	capreomycin	Uncertain significance
rrl	1475970	n.2313C>T	non_coding_transcript_exon_variant	0.87	linezolid	Uncertain significance
rrl	1475975	n.2318C>T	non_coding_transcript_exon_variant	0.84	capreomycin	Uncertain significance
rrl	1475975	n.2318C>T	non_coding_transcript_exon_variant	0.84	linezolid	Uncertain significance
rrl	1475977	n.2320A>G	non_coding_transcript_exon_variant	0.82	capreomycin	Uncertain significance
rrl	1475977	n.2320A>G	non_coding_transcript_exon_variant	0.82	linezolid	Uncertain significance
rrl	1475978	n.2321C>T	non_coding_transcript_exon_variant	0.82	capreomycin	Uncertain significance
rrl	1475978	n.2321C>T	non_coding_transcript_exon_variant	0.82	linezolid	Uncertain significance
rrl	1475988	n.2331A>G	non_coding_transcript_exon_variant	0.82	capreomycin	Not assoc w R
rrl	1475988	n.2331A>G	non_coding_transcript_exon_variant	0.82	linezolid	Uncertain significance
rrl	1475991	n.2334T>A	non_coding_transcript_exon_variant	0.78	capreomycin
rrl	1475991	n.2334T>A	non_coding_transcript_exon_variant	0.78	linezolid
rrl	1475993	n.2336C>T	non_coding_transcript_exon_variant	0.78	capreomycin	Uncertain significance
rrl	1475993	n.2336C>T	non_coding_transcript_exon_variant	0.78	linezolid	Uncertain significance
rrl	1475996	n.2339T>G	non_coding_transcript_exon_variant	0.78	capreomycin
rrl	1475996	n.2339T>G	non_coding_transcript_exon_variant	0.78	linezolid
rrl	1476130	n.2473G>A	non_coding_transcript_exon_variant	0.54	capreomycin	Uncertain significance
rrl	1476130	n.2473G>A	non_coding_transcript_exon_variant	0.54	linezolid	Uncertain significance
rrl	1476131	n.2474C>T	non_coding_transcript_exon_variant	0.57	capreomycin	Uncertain significance
rrl	1476131	n.2474C>T	non_coding_transcript_exon_variant	0.57	linezolid	Uncertain significance
rrl	1476141	n.2484A>G	non_coding_transcript_exon_variant	0.69	capreomycin	Uncertain significance
rrl	1476141	n.2484A>G	non_coding_transcript_exon_variant	0.69	linezolid	Uncertain significance
rrl	1476215	n.2558C>T	non_coding_transcript_exon_variant	0.83	capreomycin	Uncertain significance
rrl	1476215	n.2558C>T	non_coding_transcript_exon_variant	0.83	linezolid	Uncertain significance
rrl	1476224	n.2567A>G	non_coding_transcript_exon_variant	0.83	capreomycin	Uncertain significance
rrl	1476224	n.2567A>G	non_coding_transcript_exon_variant	0.83	linezolid	Uncertain significance
rrl	1476235	n.2578A>G	non_coding_transcript_exon_variant	0.82	capreomycin
rrl	1476235	n.2578A>G	non_coding_transcript_exon_variant	0.82	linezolid
rrl	1476245	n.2588C>T	non_coding_transcript_exon_variant	0.83	capreomycin	Uncertain significance
rrl	1476245	n.2588C>T	non_coding_transcript_exon_variant	0.83	linezolid	Uncertain significance
rrl	1476252	n.2595T>G	non_coding_transcript_exon_variant	0.84	capreomycin	Uncertain significance
rrl	1476252	n.2595T>G	non_coding_transcript_exon_variant	0.84	linezolid	Uncertain significance
rrl	1476256	n.2599A>G	non_coding_transcript_exon_variant	0.84	capreomycin	Uncertain significance
rrl	1476256	n.2599A>G	non_coding_transcript_exon_variant	0.84	linezolid	Uncertain significance
rrl	1476260	n.2603A>G	non_coding_transcript_exon_variant	0.84	capreomycin	Not assoc w R
rrl	1476260	n.2603A>G	non_coding_transcript_exon_variant	0.84	linezolid	Uncertain significance
rrl	1476281	n.2624T>C	non_coding_transcript_exon_variant	0.84	capreomycin	Uncertain significance
rrl	1476281	n.2624T>C	non_coding_transcript_exon_variant	0.84	linezolid	Uncertain significance
rrl	1476288	n.2635_2643delGCACCCCCG	non_coding_transcript_exon_variant	0.75	capreomycin
rrl	1476288	n.2635_2643delGCACCCCCG	non_coding_transcript_exon_variant	0.75	linezolid
rrl	1476299	n.2642C>T	non_coding_transcript_exon_variant	0.7	capreomycin	Uncertain significance
rrl	1476299	n.2642C>T	non_coding_transcript_exon_variant	0.7	linezolid	Uncertain significance
rrl	1476301	n.2644_2645insCGGTGGCTT	non_coding_transcript_exon_variant	0.68	capreomycin
rrl	1476301	n.2644_2645insCGGTGGCTT	non_coding_transcript_exon_variant	0.68	linezolid
rrl	1476307	n.2650A>T	non_coding_transcript_exon_variant	0.69	capreomycin
rrl	1476307	n.2650A>T	non_coding_transcript_exon_variant	0.69	linezolid
rrl	1476309	n.2652G>C	non_coding_transcript_exon_variant	0.64	capreomycin	Uncertain significance
rrl	1476309	n.2652G>C	non_coding_transcript_exon_variant	0.64	linezolid	Uncertain significance
rrl	1476311	n.2654G>C	non_coding_transcript_exon_variant	0.66	capreomycin	Uncertain significance
rrl	1476311	n.2654G>C	non_coding_transcript_exon_variant	0.66	linezolid	Uncertain significance
rrl	1476312	n.2655T>C	non_coding_transcript_exon_variant	0.67	capreomycin	Uncertain significance
rrl	1476312	n.2655T>C	non_coding_transcript_exon_variant	0.67	linezolid	Uncertain significance
rrl	1476316	n.2659G>A	non_coding_transcript_exon_variant	0.78	capreomycin
rrl	1476316	n.2659G>A	non_coding_transcript_exon_variant	0.78	linezolid
rrl	1476359	n.2702C>G	non_coding_transcript_exon_variant	0.93	capreomycin	Uncertain significance
rrl	1476359	n.2702C>G	non_coding_transcript_exon_variant	0.93	linezolid	Uncertain significance
rrl	1476363	n.2706A>G	non_coding_transcript_exon_variant	0.92	capreomycin
rrl	1476363	n.2706A>G	non_coding_transcript_exon_variant	0.92	linezolid
rrl	1476366	n.2709A>C	non_coding_transcript_exon_variant	0.92	capreomycin
rrl	1476366	n.2709A>C	non_coding_transcript_exon_variant	0.92	linezolid
rrl	1476368	n.2711T>C	non_coding_transcript_exon_variant	0.92	capreomycin	Uncertain significance
rrl	1476368	n.2711T>C	non_coding_transcript_exon_variant	0.92	linezolid
rrl	1476369	n.2712C>T	non_coding_transcript_exon_variant	0.92	capreomycin	Uncertain significance
rrl	1476369	n.2712C>T	non_coding_transcript_exon_variant	0.92	linezolid	Uncertain significance
rrl	1476374	n.2717T>G	non_coding_transcript_exon_variant	0.92	capreomycin
rrl	1476374	n.2717T>G	non_coding_transcript_exon_variant	0.92	linezolid
rrl	1476381	n.2724G>C	non_coding_transcript_exon_variant	0.94	capreomycin	Uncertain significance
rrl	1476381	n.2724G>C	non_coding_transcript_exon_variant	0.94	linezolid	Uncertain significance
rrl	1476428	n.2771C>T	non_coding_transcript_exon_variant	0.9	capreomycin	Not assoc w R
rrl	1476428	n.2771C>T	non_coding_transcript_exon_variant	0.9	linezolid	Uncertain significance
rrl	1476429	n.2772A>C	non_coding_transcript_exon_variant	0.9	capreomycin	Uncertain significance
rrl	1476429	n.2772A>C	non_coding_transcript_exon_variant	0.9	linezolid	Uncertain significance
rrl	1476481	n.2824T>C	non_coding_transcript_exon_variant	0.81	capreomycin	Not assoc w R
rrl	1476481	n.2824T>C	non_coding_transcript_exon_variant	0.81	linezolid	Uncertain significance
rrl	1476506	n.2849T>C	non_coding_transcript_exon_variant	0.53	capreomycin	Not assoc w R
rrl	1476506	n.2849T>C	non_coding_transcript_exon_variant	0.53	linezolid	Uncertain significance
rrl	1476515	n.2858C>T	non_coding_transcript_exon_variant	0.48	capreomycin	Uncertain significance
rrl	1476515	n.2858C>T	non_coding_transcript_exon_variant	0.48	linezolid
rpsA	1833952	c.411C>A	synonymous_variant	0.49	pyrazinamide
rpsA	1833955	c.414G>T	synonymous_variant	0.47	pyrazinamide
rpsA	1833958	c.417C>T	synonymous_variant	0.46	pyrazinamide
rpsA	1833959	p.Leu140Val	missense_variant	0.47	pyrazinamide
rpsA	1833970	c.429G>C	synonymous_variant	0.49	pyrazinamide
rpsA	1833976	c.435C>T	synonymous_variant	0.53	pyrazinamide
rpsA	1833979	c.438T>C	synonymous_variant	0.57	pyrazinamide
rpsA	1833985	c.444G>T	synonymous_variant	0.63	pyrazinamide
rpsA	1833994	c.453G>C	synonymous_variant	0.65	pyrazinamide
rpsA	1833997	c.456G>T	synonymous_variant	0.65	pyrazinamide
rpsA	1834000	c.459G>T	synonymous_variant	0.65	pyrazinamide
rpsA	1834012	c.471G>A	synonymous_variant	0.65	pyrazinamide
rpsA	1834015	c.474G>C	synonymous_variant	0.67	pyrazinamide
rpsA	1834018	c.477C>T	synonymous_variant	0.67	pyrazinamide
rpsA	1834024	c.483G>C	synonymous_variant	0.67	pyrazinamide
rpsA	1834034	p.Ile165Val	missense_variant	0.65	pyrazinamide
rpsA	1834039	c.498C>T	synonymous_variant	0.65	pyrazinamide
rpsA	1834040	p.Lys167Gln	missense_variant	0.65	pyrazinamide
rpsA	1834069	c.528G>C	synonymous_variant	0.67	pyrazinamide
rpsA	1834090	c.549G>T	synonymous_variant	0.54	pyrazinamide
rpsA	1834099	c.558C>G	synonymous_variant	0.46	pyrazinamide
rpsA	1834105	c.564C>T	synonymous_variant	0.48	pyrazinamide
rpsA	1834108	c.567C>G	synonymous_variant	0.48	pyrazinamide
rpsA	1834114	c.573G>C	synonymous_variant	0.47	pyrazinamide
rpsA	1834123	c.582C>T	synonymous_variant	0.4	pyrazinamide
rpsA	1834129	c.588C>T	synonymous_variant	0.26	pyrazinamide
rpsA	1834273	c.732C>T	synonymous_variant	0.34	pyrazinamide	Not assoc w R - Interim
rpsA	1834286	c.745_746delTCinsAG	synonymous_variant	0.31	pyrazinamide
rpsA	1834294	c.753G>T	synonymous_variant	0.32	pyrazinamide
rpsA	1834298	p.Gln253Glu	missense_variant	0.33	pyrazinamide
tlyA	1918631	p.Pro231Arg	missense_variant	1.0	capreomycin
PPE35	2168149	p.Pro822Ser	missense_variant	1.0	pyrazinamide	Not assoc w R
Rv2680	2995848	c.-257G>A	upstream_gene_variant	1.0	capreomycin
Rv3236c	3613636	c.-520A>G	upstream_gene_variant	1.0	pyrazinamide	Not assoc w R
clpC1	4039729	p.Asp326Asn	missense_variant	0.95	pyrazinamide	Not assoc w R
embC	4242643	c.2781C>T	synonymous_variant	1.0	ethambutol	Not assoc w R
whiB6	4338595	c.-75delG	upstream_gene_variant	1.0	kanamycin	Not assoc w R
					capreomycin	Not assoc w R
					amikacin	Not assoc w R