TB-Profiler result

Run: ERR3797019
Summary

Run ID: ERR3797019

Sample name:

Date: 2024-04-15T04:26:03.371334

Number of reads: 3313836

Percentage reads mapped: 80.31

Median coverage: 100.0

Strain: La1.8.1

Spoligotype:

Drug-resistance: Other

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
La1.8 M.bovis None 1.0
La1.8.1 M.bovis None 1.0
La1 M.bovis None 0.99
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol
pyrazinamide pncA p.His57Asp Assoc w R
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
pncA 2289073 p.His57Asp missense_variant 1.0 pyrazinamide Assoc w R
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
dnaA 467 p.His156Arg missense_variant 1.0 isoniazid Not assoc w R
dnaA 561 p.His187Gln missense_variant 0.77 isoniazid Uncertain significance
dnaA 741 c.741T>C synonymous_variant 0.15 isoniazid Not assoc w R - Interim
dnaA 805 c.805T>C synonymous_variant 0.15 isoniazid
dnaA 822 c.822A>G synonymous_variant 0.15 isoniazid
dnaA 828 c.828T>C synonymous_variant 0.14 isoniazid Not assoc w R - Interim
dnaA 837 c.837A>G synonymous_variant 0.14 isoniazid
dnaA 840 p.Glu280Asp missense_variant 0.13 isoniazid
dnaA 843 c.843T>C synonymous_variant 0.16 isoniazid Not assoc w R - Interim
dnaA 846 c.846T>C synonymous_variant 0.15 isoniazid
dnaA 849 c.849A>G synonymous_variant 0.15 isoniazid
gyrB 5752 c.513G>A synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6172 c.933C>T synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrB 6196 c.957C>G synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrB 6202 c.963C>T synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6203 p.Ser322Ala missense_variant 0.17 levofloxacin
moxifloxacin
gyrB 6242 p.Arg335Lys missense_variant 0.21 levofloxacin
moxifloxacin
gyrB 6250 c.1011A>G synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6253 c.1014G>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrB 6259 p.Asp340Glu missense_variant 0.21 levofloxacin
moxifloxacin
gyrB 6406 c.1167C>T synonymous_variant 0.98 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6446 p.Ala403Ser missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Uncertain significance
gyrA 6634 c.-668T>C upstream_gene_variant 0.23 levofloxacin
moxifloxacin
gyrA 6637 c.-665T>G upstream_gene_variant 0.24 levofloxacin
moxifloxacin
gyrA 6640 c.-662A>C upstream_gene_variant 0.22 levofloxacin
moxifloxacin
gyrA 6643 c.-659A>G upstream_gene_variant 0.21 levofloxacin
moxifloxacin
gyrA 6649 c.-653T>C upstream_gene_variant 0.26 levofloxacin
moxifloxacin
gyrA 6652 c.-650C>G upstream_gene_variant 0.26 levofloxacin
moxifloxacin
gyrA 6655 c.-647T>C upstream_gene_variant 0.27 levofloxacin
moxifloxacin
gyrA 6673 c.-629A>T upstream_gene_variant 0.26 levofloxacin
moxifloxacin
gyrA 6700 c.-602T>C upstream_gene_variant 0.24 levofloxacin
moxifloxacin
gyrA 6703 c.-599G>C upstream_gene_variant 0.23 levofloxacin
moxifloxacin
gyrA 6709 c.-593A>G upstream_gene_variant 0.24 levofloxacin
moxifloxacin
gyrA 6712 c.-590G>C upstream_gene_variant 0.24 levofloxacin
moxifloxacin
gyrA 6724 c.-578G>C upstream_gene_variant 0.24 levofloxacin
moxifloxacin
gyrA 6730 c.-572A>C upstream_gene_variant 0.28 levofloxacin
moxifloxacin
gyrB 6745 c.1506T>C synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7715 c.414G>C synonymous_variant 0.13 levofloxacin
moxifloxacin
gyrA 7730 p.Arg143Ser missense_variant 0.14 levofloxacin
moxifloxacin
gyrA 8048 c.747C>A synonymous_variant 0.99 levofloxacin
moxifloxacin
gyrA 8189 c.888G>C synonymous_variant 0.13 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8190 p.Ala297Thr missense_variant 0.13 levofloxacin
moxifloxacin
gyrA 8198 c.897T>C synonymous_variant 0.14 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8201 c.900C>G synonymous_variant 0.14 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8207 c.906T>C synonymous_variant 0.14 levofloxacin
moxifloxacin
gyrA 8219 c.918T>C synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8228 c.927G>T synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8234 c.933T>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8235 c.934_936delTTAinsCG frameshift_variant&missense_variant 0.18 levofloxacin
moxifloxacin
gyrA 8246 c.945C>G synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8247 p.Ile316Val missense_variant 0.18 levofloxacin
moxifloxacin
gyrA 8253 p.Ile318Val missense_variant 0.2 levofloxacin
moxifloxacin
gyrA 8264 c.963T>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8267 c.966G>C synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8283 c.982_984delATCinsCT frameshift_variant&missense_variant 0.17 levofloxacin
moxifloxacin
gyrA 8288 c.987T>C synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8294 c.993T>C synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8324 c.1023T>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 9143 c.1842T>C synonymous_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9217 p.Asp639Ala missense_variant 0.98 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
Rv0010c 13197 p.Thr121Ser missense_variant 1.0 isoniazid Not assoc w R
Rv0010c 13228 c.330delG frameshift_variant 1.0 isoniazid Uncertain significance
Rv0010c 13460 c.99T>C synonymous_variant 1.0 isoniazid Not assoc w R
fgd1 491742 c.960T>C synonymous_variant 1.0 clofazimine Not assoc w R
pretomanid
delamanid Not assoc w R - Interim
Rv0565c 657578 c.-108T>C upstream_gene_variant 1.0 ethionamide
nusG 734329 p.Ala26Thr missense_variant 1.0 rifampicin Uncertain significance
rpoB 760184 c.378A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760196 c.390C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 760235 c.429T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760244 c.438G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760253 c.447T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760283 c.477G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 760298 c.492G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760310 c.504G>C synonymous_variant 0.21 rifampicin
rpoB 760316 c.510C>G synonymous_variant 0.19 rifampicin
rpoB 760328 c.522G>C synonymous_variant 0.14 rifampicin
rpoB 760331 c.525G>T synonymous_variant 0.14 rifampicin
rpoB 760334 c.528G>C synonymous_variant 0.14 rifampicin
rpoB 760340 c.534G>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 760361 c.555T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760370 c.564C>G synonymous_variant 0.15 rifampicin
rpoB 760373 c.567C>G synonymous_variant 0.15 rifampicin
rpoB 760376 p.Asp190Glu missense_variant 0.17 rifampicin Uncertain significance
rpoB 760400 c.594G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760406 c.600G>C synonymous_variant 0.16 rifampicin
rpoB 760407 p.Ser201Gly missense_variant 0.17 rifampicin Uncertain significance
rpoB 760424 c.618C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760430 c.624T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760457 c.651C>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 760460 c.654G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760475 c.669A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760481 c.675G>T synonymous_variant 0.21 rifampicin
rpoB 760484 c.678A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760487 c.681G>C synonymous_variant 0.19 rifampicin
rpoB 760511 c.705G>C synonymous_variant 0.15 rifampicin
rpoB 760522 p.Ser239Asn missense_variant 0.19 rifampicin Uncertain significance
rpoB 760532 c.726T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760535 c.729C>G synonymous_variant 0.13 rifampicin
rpoB 760541 c.735G>C synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoB 760547 c.741G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761015 c.1209G>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 761027 c.1221A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761036 c.1230G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 761037 c.1231T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 761051 c.1245G>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761054 c.1248G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761057 c.1251G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761060 c.1254C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761063 c.1257C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761075 c.1269G>A synonymous_variant 0.17 rifampicin
rpoB 761097 c.1291_1293delAGCinsTCG synonymous_variant 0.15 rifampicin
rpoB 761102 c.1296A>G synonymous_variant 0.15 rifampicin
rpoB 761132 c.1326G>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 761133 c.1327T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 761147 c.1341C>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 762143 c.2337T>C synonymous_variant 0.13 rifampicin
rpoB 762149 c.2343G>C synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoB 762158 c.2352G>C synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoB 762167 c.2361T>C synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoB 762176 c.2370T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 762185 c.2379G>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 762218 c.2412T>C synonymous_variant 0.14 rifampicin
rpoB 762362 p.Glu852Asp missense_variant 0.16 rifampicin
rpoB 762369 c.2563T>C synonymous_variant 0.15 rifampicin
rpoC 762374 c.-996G>C upstream_gene_variant 0.16 rifampicin
rpoC 762395 c.-975G>C upstream_gene_variant 0.13 rifampicin
rpoC 762401 c.-969G>C upstream_gene_variant 0.14 rifampicin
rpoB 762404 c.2598T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 762410 c.-960T>C upstream_gene_variant 0.17 rifampicin
rpoB 762416 c.2610A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 762434 c.-936T>C upstream_gene_variant 0.19 rifampicin
rpoC 762443 c.-927G>C upstream_gene_variant 0.18 rifampicin
rpoB 762449 c.2643C>A synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 762452 c.2646G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 762470 c.2664G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 762491 c.2685T>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>C synonymous_variant 0.99 rifampicin Not assoc w R
rpoB 763040 c.3234C>G synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 763053 c.3247T>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 763070 c.3264T>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 763115 c.3309T>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 763166 c.3360A>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 763468 c.99G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 763486 c.117T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 763492 c.123G>A synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 763528 c.159G>A synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 763531 c.162G>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 763573 c.204G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 763576 c.207C>G synonymous_variant 0.17 rifampicin
rpoC 763594 c.225C>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 763621 c.252C>T synonymous_variant 0.15 rifampicin
rpoC 763675 c.306C>G synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoC 763702 c.333C>G synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 763709 c.340C>T synonymous_variant 0.14 rifampicin
rpoC 763771 c.402C>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 763781 p.Ser138Ala missense_variant 0.15 rifampicin
rpoC 763787 p.Asp140Asn missense_variant 0.14 rifampicin
rpoC 763792 p.Glu141Asp missense_variant 0.16 rifampicin
rpoC 763807 c.438T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 763813 c.444C>G synonymous_variant 0.14 rifampicin
rpoC 764405 c.1036_1038delAGGinsCC frameshift_variant&missense_variant 0.14 rifampicin
rpoC 764434 c.1065A>G synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 764435 c.1066_1068delAGGinsCA frameshift_variant&missense_variant 0.15 rifampicin
rpoC 764446 c.1077T>C synonymous_variant 0.16 rifampicin
rpoC 764449 c.1080G>C synonymous_variant 0.15 rifampicin
rpoC 764452 c.1083T>C synonymous_variant 0.15 rifampicin
rpoC 764458 c.1089G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 764461 c.1092A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764485 c.1116G>C synonymous_variant 0.16 rifampicin
rpoC 764491 c.1122G>T synonymous_variant 0.14 rifampicin
rpoC 764497 c.1128A>G synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 764500 c.1131C>G synonymous_variant 0.14 rifampicin
rpoC 764521 c.1152T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 764527 c.1158C>G synonymous_variant 0.16 rifampicin
rpoC 764551 c.1182G>C synonymous_variant 0.13 rifampicin
rpoC 764575 c.1206T>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 764605 c.1236G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 764611 c.1242G>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764626 c.1257C>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764632 c.1263T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764713 c.1344G>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764716 c.1347G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764746 c.1377G>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764752 c.1383G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764758 c.1389C>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764764 c.1395T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 764797 c.1428G>C synonymous_variant 0.15 rifampicin
rpoC 764803 c.1434C>T synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoC 764809 c.1440C>T synonymous_variant 0.14 rifampicin Not assoc w R
rpoC 764827 c.1458G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 764843 p.Ala492Ser missense_variant 0.18 rifampicin
rpoC 764858 c.1489T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 764875 c.1506C>A synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 764887 c.1518G>C synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoC 764888 c.1519_1521delTTGinsCC frameshift_variant&missense_variant 0.14 rifampicin
rpoC 764911 c.1542A>G synonymous_variant 0.14 rifampicin
rpoC 764912 p.Met515Gln missense_variant 0.14 rifampicin Uncertain significance
rpoC 764923 c.1554A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 764935 c.1566T>C synonymous_variant 0.18 rifampicin
rpoC 764948 c.1579T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 764953 c.1584G>C synonymous_variant 0.15 rifampicin
rpoC 764968 c.1599T>C synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoC 765892 c.2523T>C synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoC 765898 c.2529C>T synonymous_variant 0.13 rifampicin
rpoC 765904 c.2535C>G synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 765937 c.2568T>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 766804 c.3435A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 767098 c.3729T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 767104 c.3735C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 767105 c.3736_3738delAACinsCG frameshift_variant&missense_variant 0.14 rifampicin
rpoC 767119 c.3750A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 767149 c.3780C>A synonymous_variant 0.16 rifampicin
rpoC 767152 c.3783T>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 767158 c.3789T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 767167 c.3798C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 767180 p.Ala1271Gln missense_variant 0.15 rifampicin
rpoC 767191 c.3822C>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
mmpL5 775639 p.Ile948Val missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
mmpL5 776100 p.Thr794Ile missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781802 c.243G>C synonymous_variant 0.15 streptomycin
rpsL 781814 c.255C>T synonymous_variant 0.17 streptomycin
rpsL 781817 c.258G>T synonymous_variant 0.17 streptomycin
rpsL 781829 c.270G>C synonymous_variant 0.18 streptomycin
rpsL 781832 c.273T>C synonymous_variant 0.17 streptomycin
rpsL 781835 c.276T>C synonymous_variant 0.16 streptomycin Not assoc w R - Interim
rpsL 781859 c.300T>C synonymous_variant 0.19 streptomycin Not assoc w R - Interim
rpsL 781868 c.309T>C synonymous_variant 0.22 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.22 streptomycin
rpsL 781877 c.318T>C synonymous_variant 0.2 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.2 streptomycin
rpsL 781895 c.336G>A synonymous_variant 0.17 streptomycin
rpsL 781898 c.339A>C synonymous_variant 0.18 streptomycin
rpsL 781916 c.357T>G synonymous_variant 0.2 streptomycin
rpsL 781929 p.Gly124Ser missense_variant 0.2 streptomycin Uncertain significance
rplC 801454 p.Glu216Gln missense_variant 1.0 linezolid
Rv1129c 1254562 c.-28T>C upstream_gene_variant 1.0 moxifloxacin Not assoc w R
levofloxacin Not assoc w R
rifampicin Not assoc w R
isoniazid Not assoc w R
Rv1129c 1254582 c.-48A>G upstream_gene_variant 1.0 moxifloxacin Uncertain significance
levofloxacin Uncertain significance
rifampicin Not assoc w R
isoniazid Not assoc w R
fbiC 1302899 c.-32A>G upstream_gene_variant 1.0 clofazimine Uncertain significance
pretomanid
delamanid Uncertain significance
sigE 1364790 c.378T>C synonymous_variant 0.13 pyrazinamide
sigE 1364799 c.387G>C synonymous_variant 0.12 pyrazinamide
embR 1417554 c.-207C>G upstream_gene_variant 1.0 ethambutol
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471935 n.90T>C non_coding_transcript_exon_variant 0.87 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472112 n.267C>T non_coding_transcript_exon_variant 0.13 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472113 n.268T>C non_coding_transcript_exon_variant 0.14 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472150 n.305T>A non_coding_transcript_exon_variant 0.25 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472251 n.406G>A non_coding_transcript_exon_variant 0.31 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472285 n.440A>G non_coding_transcript_exon_variant 0.17 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472289 n.444T>G non_coding_transcript_exon_variant 0.15 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472290 n.445C>G non_coding_transcript_exon_variant 0.16 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472297 n.453_465delGTCCGGGTTCTCT non_coding_transcript_exon_variant 0.19 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472313 n.468delGinsCA non_coding_transcript_exon_variant 0.18 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472315 n.470T>G non_coding_transcript_exon_variant 0.17 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472324 n.479G>C non_coding_transcript_exon_variant 0.18 streptomycin Uncertain significance
kanamycin
capreomycin
amikacin
rrs 1472325 n.480G>C non_coding_transcript_exon_variant 0.18 streptomycin Uncertain significance
kanamycin
capreomycin
amikacin
rrs 1472337 n.492C>G non_coding_transcript_exon_variant 0.2 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472380 n.535G>C non_coding_transcript_exon_variant 0.2 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472438 n.593T>C non_coding_transcript_exon_variant 0.23 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472446 n.601T>A non_coding_transcript_exon_variant 0.21 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472452 n.607G>A non_coding_transcript_exon_variant 0.21 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472456 n.611T>C non_coding_transcript_exon_variant 0.22 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472464 n.619A>G non_coding_transcript_exon_variant 0.24 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472755 n.910G>A non_coding_transcript_exon_variant 0.54 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472847 n.1002G>T non_coding_transcript_exon_variant 0.46 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472848 n.1003T>G non_coding_transcript_exon_variant 0.44 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472849 n.1004C>G non_coding_transcript_exon_variant 0.44 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472858 n.1013G>T non_coding_transcript_exon_variant 0.46 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472859 n.1014G>C non_coding_transcript_exon_variant 0.46 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472860 n.1015C>A non_coding_transcript_exon_variant 0.46 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472953 n.1108G>A non_coding_transcript_exon_variant 0.47 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472957 n.1112C>T non_coding_transcript_exon_variant 0.44 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472969 n.1124A>G non_coding_transcript_exon_variant 0.38 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472978 n.1133T>C non_coding_transcript_exon_variant 0.32 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473104 n.1259C>T non_coding_transcript_exon_variant 0.61 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473110 n.1265T>G non_coding_transcript_exon_variant 0.66 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473111 n.1266A>G non_coding_transcript_exon_variant 0.68 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473123 n.1278delAinsTC non_coding_transcript_exon_variant 0.74 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473276 n.1431A>G non_coding_transcript_exon_variant 0.46 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473301 n.1456T>C non_coding_transcript_exon_variant 0.42 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrl 1473770 n.113T>G non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473788 n.131A>G non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid
rrl 1473806 n.149C>T non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474266 n.609T>C non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474269 n.612C>T non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474287 n.630_644delTCCTTTTCCTCTCCGinsCTCCTTC non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1474303 n.646A>T non_coding_transcript_exon_variant 0.27 capreomycin
linezolid
rrl 1474306 n.649A>T non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1474308 n.653_654delTG non_coding_transcript_exon_variant 0.27 capreomycin
linezolid
rrl 1474362 n.705A>G non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474387 n.730C>T non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474446 n.789C>T non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474552 n.895C>T non_coding_transcript_exon_variant 0.41 capreomycin
linezolid
rrl 1474672 n.1015C>T non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474673 n.1016T>C non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474676 n.1019T>A non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474710 n.1053delTinsACAC non_coding_transcript_exon_variant 0.27 capreomycin
linezolid
rrl 1474718 n.1061A>T non_coding_transcript_exon_variant 0.27 capreomycin
linezolid
rrl 1474720 n.1065_1066delTG non_coding_transcript_exon_variant 0.29 capreomycin
linezolid
rrl 1474753 n.1096A>G non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid
rrl 1474760 n.1103A>G non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475088 n.1431A>G non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1475355 n.1698C>T non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475363 n.1706C>T non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid
rrl 1475369 n.1712G>T non_coding_transcript_exon_variant 0.37 capreomycin
linezolid
rrl 1475376 n.1719A>C non_coding_transcript_exon_variant 0.35 capreomycin
linezolid Uncertain significance
rrl 1475380 n.1723C>T non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475387 n.1730C>T non_coding_transcript_exon_variant 0.38 capreomycin
linezolid
rrl 1475397 n.1740G>A non_coding_transcript_exon_variant 0.4 capreomycin
linezolid
rrl 1475402 n.1745C>T non_coding_transcript_exon_variant 0.41 capreomycin
linezolid
rrl 1475403 n.1746T>G non_coding_transcript_exon_variant 0.41 capreomycin
linezolid
rrl 1475405 n.1748A>T non_coding_transcript_exon_variant 0.44 capreomycin
linezolid
rrl 1475406 n.1749T>G non_coding_transcript_exon_variant 0.46 capreomycin
linezolid
rrl 1475419 n.1762C>T non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid
rrl 1475429 n.1772G>A non_coding_transcript_exon_variant 0.54 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475452 n.1795C>A non_coding_transcript_exon_variant 0.54 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475458 n.1801C>T non_coding_transcript_exon_variant 0.53 capreomycin
linezolid
rrl 1475460 n.1803A>G non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475480 n.1823A>G non_coding_transcript_exon_variant 0.44 capreomycin
linezolid
rrl 1475505 n.1848G>A non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.47 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475532 n.1875A>G non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475544 n.1887A>T non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475545 n.1888T>G non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475602 n.1945G>C non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid
rrl 1475603 n.1946G>A non_coding_transcript_exon_variant 0.29 capreomycin
linezolid
rrl 1475604 n.1947A>C non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid
rrl 1475608 n.1951T>C non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid
rrl 1475612 n.1955G>C non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid
rrl 1475619 n.1962C>T non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1475621 n.1964T>C non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid
rrl 1475629 n.1972_1973insT non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1475637 n.1980T>G non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid
rrl 1475638 n.1981C>T non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1475639 n.1982C>G non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid
rrl 1475643 n.1986C>G non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1475647 n.1990G>C non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1475659 n.2002G>A non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475760 n.2103C>T non_coding_transcript_exon_variant 0.58 capreomycin
linezolid
rrl 1475763 n.2106C>T non_coding_transcript_exon_variant 0.59 capreomycin Uncertain significance
linezolid
rrl 1475916 n.2259C>T non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.52 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1475991 n.2334T>C non_coding_transcript_exon_variant 0.52 capreomycin Uncertain significance
linezolid
rrl 1475995 n.2338G>A non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid
rrl 1476088 n.2431A>C non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476103 n.2446C>G non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid
rrl 1476105 n.2448G>A non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid
rrl 1476106 n.2449A>T non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid
rrl 1476110 n.2453G>C non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid
rrl 1476115 n.2458T>C non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476131 n.2474C>T non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476214 n.2557G>T non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476215 n.2558C>T non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.45 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476251 n.2594T>G non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid
rrl 1476252 n.2595T>G non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476256 n.2599A>T non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476260 n.2603A>G non_coding_transcript_exon_variant 0.45 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.51 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476297 n.2640C>T non_coding_transcript_exon_variant 0.49 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476299 n.2642C>T non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476529 n.2872A>G non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid
rrl 1476583 n.2926G>C non_coding_transcript_exon_variant 0.31 capreomycin
linezolid
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.35 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476597 n.2940G>A non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid
rrl 1476608 n.2951C>T non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476619 n.2962C>T non_coding_transcript_exon_variant 0.35 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476674 n.3017T>C non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476679 n.3022T>C non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid
rrl 1476690 n.3033C>T non_coding_transcript_exon_variant 0.42 capreomycin Uncertain significance
linezolid
rrl 1476692 n.3035T>A non_coding_transcript_exon_variant 0.39 capreomycin
linezolid
rrl 1476693 n.3036G>A non_coding_transcript_exon_variant 0.43 capreomycin
linezolid
rrl 1476716 n.3059A>C non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid
rrl 1476723 n.3066T>A non_coding_transcript_exon_variant 0.31 capreomycin
linezolid
inhA 1673715 c.-487C>G upstream_gene_variant 0.9 ethionamide Uncertain significance
isoniazid Uncertain significance
rpsA 1833829 c.288A>G synonymous_variant 0.14 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.14 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.14 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.14 pyrazinamide
rpsA 1833862 c.321G>T synonymous_variant 0.13 pyrazinamide
rpsA 1833868 c.327C>T synonymous_variant 0.13 pyrazinamide
rpsA 1833892 c.351G>A synonymous_variant 0.13 pyrazinamide
rpsA 1833894 p.Ala118Glu missense_variant 0.13 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.13 pyrazinamide
rpsA 1833949 c.408T>C synonymous_variant 0.14 pyrazinamide
rpsA 1833970 c.429G>C synonymous_variant 0.16 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.16 pyrazinamide
rpsA 1833988 c.447C>T synonymous_variant 0.14 pyrazinamide
rpsA 1833991 c.450C>A synonymous_variant 0.14 pyrazinamide
rpsA 1834213 c.672G>C synonymous_variant 0.14 pyrazinamide
rpsA 1834234 c.693G>C synonymous_variant 0.13 pyrazinamide
rpsA 1834249 c.708T>C synonymous_variant 0.13 pyrazinamide
rpsA 1834303 c.762T>G synonymous_variant 0.14 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.15 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 0.15 pyrazinamide Not assoc w R - Interim
rpsA 1834396 c.855G>C synonymous_variant 0.12 pyrazinamide
rpsA 1834859 p.Ala440Thr missense_variant 1.0 pyrazinamide Uncertain significance
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
bacA 2062922 p.Ile603Val missense_variant 1.0 streptomycin Not assoc w R
kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
bacA 2063157 c.1572C>G synonymous_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
ndh 2103173 c.-132delG upstream_gene_variant 1.0 ethionamide
delamanid
isoniazid
katG 2154724 p.Arg463Leu missense_variant 1.0 isoniazid Not assoc w R
katG 2155503 c.609C>T synonymous_variant 1.0 isoniazid Not assoc w R
katG 2156025 c.87C>A synonymous_variant 1.0 isoniazid Not assoc w R
PPE35 2167926 p.Leu896Ser missense_variant 1.0 pyrazinamide Not assoc w R
PPE35 2168011 p.Ser868Arg missense_variant 1.0 pyrazinamide Uncertain significance
PPE35 2168319 p.Thr765Ile missense_variant 1.0 pyrazinamide Uncertain significance
PPE35 2168814 c.1798dupA frameshift_variant 1.0 pyrazinamide Uncertain significance
Rv1979c 2222308 p.Asp286Gly missense_variant 0.98 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
kasA 2518132 c.18C>T synonymous_variant 1.0 isoniazid
eis 2715125 p.Thr70Ala missense_variant 1.0 amikacin Uncertain significance
kanamycin Uncertain significance
Rv2477c 2782927 c.1116A>G synonymous_variant 1.0 ethambutol Not assoc w R
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R
amikacin Not assoc w R - Interim
Rv2681 2997325 p.Ala196Val missense_variant 1.0 capreomycin Uncertain significance
Rv2752c 3066555 c.-364C>T upstream_gene_variant 1.0 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
ald 3086728 c.-92C>T upstream_gene_variant 1.0 cycloserine
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
ald 3087084 c.266delA frameshift_variant 1.0 cycloserine
Rv3083 3448783 p.Val94Ile missense_variant 1.0 ethionamide Uncertain significance
lpqB 3623372 c.1539G>C synonymous_variant 1.0 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R
lpqB 3623730 p.Ser394Leu missense_variant 0.98 bedaquiline Uncertain significance
rifampicin Not assoc w R
lpqB 3624350 c.561G>T synonymous_variant 0.97 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R
lpqB 3624486 p.Asp142Gly missense_variant 0.99 bedaquiline Uncertain significance
rifampicin Not assoc w R
lpqB 3624593 c.318G>A synonymous_variant 1.0 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R
lpqB 3624710 c.201G>A synonymous_variant 0.95 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R
mtrB 3625065 p.Met517Leu missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
mtrB 3625222 c.1392T>C synonymous_variant 0.14 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625246 c.-336G>C upstream_gene_variant 0.13 bedaquiline
rifampicin
mtrB 3625252 c.1362G>C synonymous_variant 0.13 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625255 c.-345T>G upstream_gene_variant 0.13 bedaquiline
rifampicin
mtrA 3626804 c.546A>G synonymous_variant 0.14 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3626846 c.504G>A synonymous_variant 0.16 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626858 c.-245A>G upstream_gene_variant 0.14 bedaquiline
rifampicin
mtrB 3626861 c.-248C>G upstream_gene_variant 0.14 bedaquiline
rifampicin
mtrB 3626866 c.-253T>C upstream_gene_variant 0.13 bedaquiline
rifampicin
mtrB 3626930 c.-317A>C upstream_gene_variant 0.14 bedaquiline
rifampicin
mtrA 3626939 p.Glu137Asp missense_variant 0.15 bedaquiline
rifampicin
rpoA 3877638 c.870T>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoA 3877656 c.852T>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoA 3877662 c.846C>T synonymous_variant 0.16 rifampicin
rpoA 3877668 c.840A>G synonymous_variant 0.16 rifampicin
rpoA 3877671 c.837C>G synonymous_variant 0.15 rifampicin
rpoA 3877677 c.831G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoA 3877680 c.828G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoA 3877686 c.822A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3877692 c.816G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoA 3877704 c.804G>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3877710 c.798C>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoA 3877731 c.777G>T synonymous_variant 0.17 rifampicin
rpoA 3877743 c.765T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3877764 c.744C>G synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoA 3877900 p.Ser203Thr missense_variant 0.13 rifampicin
rpoA 3877905 c.603A>G synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoA 3877908 c.600T>C synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoA 3878187 c.321C>G synonymous_variant 0.14 rifampicin
rpoA 3878193 c.315T>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoA 3878202 c.306G>C synonymous_variant 0.17 rifampicin
rpoA 3878205 c.303T>A synonymous_variant 0.17 rifampicin
rpoA 3878217 c.291A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3878247 c.261G>C synonymous_variant 0.22 rifampicin
rpoA 3878253 c.255G>C synonymous_variant 0.22 rifampicin
rpoA 3878259 c.249G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoA 3878264 p.Ser82Gly missense_variant 0.21 rifampicin
rpoA 3878271 c.237T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoA 3878283 p.Glu75Asp missense_variant 0.19 rifampicin Uncertain significance
rpoA 3878292 c.216T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoA 3878298 c.210A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoA 3878310 c.198G>C synonymous_variant 0.18 rifampicin
rpoA 3878313 c.195G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3878322 c.186A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3878331 c.177A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3878337 c.171T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3878346 c.162T>C synonymous_variant 0.16 rifampicin
rpoA 3878630 c.-124delC upstream_gene_variant 1.0 rifampicin Not assoc w R
clpC1 4038403 c.2302T>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4038914 c.1791G>C synonymous_variant 0.13 pyrazinamide
clpC1 4038923 c.1782A>G synonymous_variant 0.17 pyrazinamide
clpC1 4038953 c.1752A>G synonymous_variant 0.19 pyrazinamide
clpC1 4038956 c.1749T>C synonymous_variant 0.19 pyrazinamide
clpC1 4038965 c.1740T>C synonymous_variant 0.2 pyrazinamide
clpC1 4038971 c.1734T>C synonymous_variant 0.19 pyrazinamide
clpC1 4038974 c.1731T>C synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
clpC1 4038989 c.1716T>C synonymous_variant 0.16 pyrazinamide
clpC1 4038997 c.1708T>C synonymous_variant 0.14 pyrazinamide Not assoc w R - Interim
clpC1 4039022 c.1683A>G synonymous_variant 0.16 pyrazinamide
clpC1 4039064 c.1641C>G synonymous_variant 0.14 pyrazinamide
clpC1 4039085 c.1620A>G synonymous_variant 0.15 pyrazinamide
clpC1 4039103 c.1602T>C synonymous_variant 0.15 pyrazinamide
clpC1 4039106 c.1599G>C synonymous_variant 0.15 pyrazinamide
clpC1 4039112 c.1593C>G synonymous_variant 0.15 pyrazinamide
clpC1 4039121 c.1584T>C synonymous_variant 0.15 pyrazinamide
clpC1 4039136 c.1569C>T synonymous_variant 0.16 pyrazinamide
clpC1 4039142 c.1563A>G synonymous_variant 0.16 pyrazinamide
clpC1 4039145 c.1560G>C synonymous_variant 0.18 pyrazinamide
clpC1 4039169 p.Glu512Asp missense_variant 0.17 pyrazinamide
clpC1 4039172 c.1533A>G synonymous_variant 0.16 pyrazinamide
clpC1 4039178 c.1527G>C synonymous_variant 0.16 pyrazinamide
clpC1 4039181 c.1522_1524delTTGinsCC frameshift_variant&missense_variant 0.15 pyrazinamide
clpC1 4039187 c.1518G>T synonymous_variant 0.14 pyrazinamide
clpC1 4039190 c.1515C>G synonymous_variant 0.14 pyrazinamide
clpC1 4039199 p.Ala502Glu missense_variant 0.16 pyrazinamide
clpC1 4039208 c.1497C>G synonymous_variant 0.17 pyrazinamide
clpC1 4039226 c.1479T>C synonymous_variant 0.13 pyrazinamide Not assoc w R - Interim
clpC1 4039244 c.1461G>C synonymous_variant 0.12 pyrazinamide
clpC1 4039286 c.1419T>C synonymous_variant 0.13 pyrazinamide
clpC1 4039298 c.1407T>C synonymous_variant 0.16 pyrazinamide
clpC1 4039310 c.1395A>G synonymous_variant 0.15 pyrazinamide
clpC1 4039313 c.1392C>T synonymous_variant 0.14 pyrazinamide
clpC1 4039319 c.1386T>C synonymous_variant 0.15 pyrazinamide Not assoc w R - Interim
clpC1 4039322 c.1383T>C synonymous_variant 0.15 pyrazinamide
clpC1 4039328 c.1377A>G synonymous_variant 0.15 pyrazinamide
clpC1 4039334 c.1371G>C synonymous_variant 0.16 pyrazinamide
clpC1 4039337 c.1368A>C synonymous_variant 0.14 pyrazinamide
clpC1 4039347 p.Arg453Lys missense_variant 0.14 pyrazinamide
clpC1 4039382 c.1323C>G synonymous_variant 0.14 pyrazinamide
clpC1 4039430 c.1275T>C synonymous_variant 0.14 pyrazinamide
clpC1 4039517 c.1188C>G synonymous_variant 0.14 pyrazinamide
clpC1 4039541 c.1164C>G synonymous_variant 0.14 pyrazinamide
clpC1 4039577 c.1128T>C synonymous_variant 0.13 pyrazinamide Not assoc w R - Interim
clpC1 4039586 c.1119G>C synonymous_variant 0.13 pyrazinamide
clpC1 4039592 c.1113G>C synonymous_variant 0.14 pyrazinamide
clpC1 4039616 c.1089G>C synonymous_variant 0.19 pyrazinamide
clpC1 4039622 c.1083C>T synonymous_variant 0.17 pyrazinamide
clpC1 4039979 c.726C>G synonymous_variant 0.13 pyrazinamide
clpC1 4040009 c.696C>G synonymous_variant 0.14 pyrazinamide
glpK 4138377 p.Val460Ala missense_variant 1.0 ethambutol Not assoc w R
moxifloxacin Not assoc w R
streptomycin Not assoc w R
levofloxacin Not assoc w R
rifampicin Not assoc w R
isoniazid Not assoc w R
embC 4240671 p.Thr270Ile missense_variant 0.99 ethambutol Not assoc w R
embC 4242642 p.Arg927His missense_variant 1.0 ethambutol Uncertain significance
embC 4242970 c.3108C>T synonymous_variant 1.0 ethambutol Not assoc w R
embA 4244220 c.988C>T synonymous_variant 0.99 ethambutol Not assoc w R
embB 4246551 p.Asn13Ser missense_variant 1.0 ethambutol Not assoc w R
embB 4246864 c.351C>T synonymous_variant 1.0 ethambutol Not assoc w R
embB 4247646 p.Glu378Ala missense_variant 1.0 ethambutol Not assoc w R
embB 4248734 p.Arg741Trp missense_variant 1.0 ethambutol Uncertain significance
aftB 4267167 p.Gln557Pro missense_variant 1.0 ethambutol Uncertain significance
aftB 4267858 p.Ile327Val missense_variant 1.0 ethambutol Not assoc w R
ubiA 4269351 c.483C>T synonymous_variant 1.0 ethambutol Not assoc w R
ubiA 4269387 p.Glu149Asp missense_variant 1.0 ethambutol Not assoc w R
ubiA 4269606 c.228T>C synonymous_variant 1.0 ethambutol Not assoc w R
ethA 4326024 p.Pro484Ser missense_variant 0.99 ethionamide
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 capreomycin
amikacin
kanamycin
gid 4407588 c.615A>G synonymous_variant 1.0 streptomycin Not assoc w R