TB-Profiler result

Run: ERR11252664
Summary

Run ID: ERR11252664

Sample name:

Date: 2024-05-22T13:15:04.336705

Number of reads: 2127556

Percentage reads mapped: 92.14

Median coverage: 64.0

Strain: lineage2.2.1

Spoligotype:

Drug-resistance: Other

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage2 East-Asian RD105 1.0
lineage2.2.1 East-Asian (Beijing) RD105;RD207;RD181 0.99
lineage2.2 East-Asian (Beijing) RD105;RD207 1.0
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol embB p.His312Arg Mutation from literature
pyrazinamide
streptomycin rrs n.462C>T Uncertain significance Mutation from literature
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine pepQ c.640_641delGT Assoc w R - Interim
c.636_637insGC Assoc w R - Interim
c.592_594delGCCinsCG Assoc w R - Interim
para-aminosalicylic_acid
delamanid fbiC c.916_918delTTCinsGT Assoc w R - Interim Confers DLM-PMD cross-resistance
bedaquiline pepQ c.640_641delGT Assoc w R - Interim Includes data from one site that only submitted resistant strains, which may have inflated the PPV
c.636_637insGC Assoc w R - Interim Includes data from one site that only submitted resistant strains, which may have inflated the PPV
c.592_594delGCCinsCG Assoc w R - Interim Includes data from one site that only submitted resistant strains, which may have inflated the PPV
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
fbiC 1303846 c.916_918delTTCinsGT frameshift_variant&missense_variant 0.16 delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
rrs 1472307 n.462C>T non_coding_transcript_exon_variant 0.36 streptomycin Uncertain significance Mutation from literature
pepQ 2859777 c.640_641delGT frameshift_variant 0.19 clofazimine Assoc w R - Interim
bedaquiline Assoc w R - Interim Includes data from one site that only submitted resistant strains, which may have inflated the PPV
pepQ 2859782 c.636_637insGC frameshift_variant 0.18 clofazimine Assoc w R - Interim
bedaquiline Assoc w R - Interim Includes data from one site that only submitted resistant strains, which may have inflated the PPV
pepQ 2859825 c.592_594delGCCinsCG frameshift_variant&synonymous_variant 0.22 clofazimine Assoc w R - Interim
bedaquiline Assoc w R - Interim Includes data from one site that only submitted resistant strains, which may have inflated the PPV
embB 4247448 p.His312Arg missense_variant 0.16 ethambutol Mutation from literature
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
dnaA 693 c.693A>C synonymous_variant 0.14 isoniazid
dnaA 699 c.699G>A synonymous_variant 0.15 isoniazid Not assoc w R - Interim
dnaA 741 c.741T>C synonymous_variant 0.13 isoniazid Not assoc w R - Interim
dnaA 750 c.750C>G synonymous_variant 0.14 isoniazid
dnaA 756 c.756T>C synonymous_variant 0.15 isoniazid
dnaA 771 c.771A>G synonymous_variant 0.13 isoniazid
dnaA 786 c.786C>T synonymous_variant 0.13 isoniazid
dnaA 795 c.795A>C synonymous_variant 0.15 isoniazid Not assoc w R - Interim
dnaA 813 c.813C>T synonymous_variant 0.14 isoniazid
dnaA 819 c.819C>T synonymous_variant 0.14 isoniazid
dnaA 822 c.822A>G synonymous_variant 0.14 isoniazid
dnaA 828 c.828T>C synonymous_variant 0.14 isoniazid Not assoc w R - Interim
dnaA 1119 c.1119G>A synonymous_variant 0.14 isoniazid
dnaA 1125 c.1125G>C synonymous_variant 0.17 isoniazid
dnaA 1134 c.1134G>C synonymous_variant 0.15 isoniazid
dnaA 1140 c.1140C>G synonymous_variant 0.16 isoniazid
dnaA 1143 c.1143G>A synonymous_variant 0.16 isoniazid Not assoc w R - Interim
dnaA 1152 c.1152A>G synonymous_variant 0.17 isoniazid
dnaA 1153 c.1153T>C synonymous_variant 0.17 isoniazid
dnaA 1161 c.1161A>G synonymous_variant 0.17 isoniazid
dnaA 1164 c.1164A>G synonymous_variant 0.17 isoniazid
dnaA 1167 c.1167A>G synonymous_variant 0.17 isoniazid Not assoc w R - Interim
dnaA 1176 c.1176A>G synonymous_variant 0.17 isoniazid
dnaA 1220 p.Asn407Ser missense_variant 0.17 isoniazid
dnaA 1230 c.1230A>G synonymous_variant 0.15 isoniazid
dnaA 1242 c.1242G>C synonymous_variant 0.15 isoniazid
dnaA 1245 c.1245G>C synonymous_variant 0.14 isoniazid Not assoc w R - Interim
gyrB 6123 p.Ala295Gly missense_variant 0.13 levofloxacin
moxifloxacin
gyrB 6127 c.888G>C synonymous_variant 0.14 levofloxacin
moxifloxacin
gyrB 6215 c.976_978delTCGinsAA frameshift_variant&missense_variant 0.14 levofloxacin Uncertain significance
moxifloxacin
gyrB 6223 c.984G>C synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6238 c.999G>A synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6242 p.Arg335Lys missense_variant 0.18 levofloxacin
moxifloxacin
gyrB 6250 c.1011A>G synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6253 c.1014G>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrB 6280 c.1041T>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrB 6283 c.1044C>T synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrB 6286 c.1047T>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrB 6292 c.1053G>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrB 6307 c.1068T>G synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6319 c.1080G>C synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 6331 c.-971A>G upstream_gene_variant 0.19 levofloxacin
moxifloxacin
gyrA 6346 c.-956C>G upstream_gene_variant 0.17 levofloxacin
moxifloxacin
gyrB 7093 c.1854T>C synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 7124 p.Ser629Thr missense_variant 0.13 levofloxacin
moxifloxacin
gyrA 7141 c.-161T>C upstream_gene_variant 0.14 levofloxacin
moxifloxacin
gyrA 7147 c.-155G>C upstream_gene_variant 0.14 levofloxacin
moxifloxacin
gyrA 7150 c.-152G>A upstream_gene_variant 0.13 levofloxacin
moxifloxacin
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7547 c.246C>T synonymous_variant 0.14 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7553 c.252C>T synonymous_variant 0.14 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7601 c.300C>G synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7607 c.306C>G synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7622 c.321C>T synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 7628 c.327G>C synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 7631 c.330G>C synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 7658 c.357A>C synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7661 c.360C>T synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 7664 c.363T>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 7670 c.369A>G synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 7676 c.375G>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 7679 c.378G>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 7683 c.382A>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 7694 c.393A>G synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 7697 c.396C>G synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 7700 c.399G>A synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7710 c.409_411delTTGinsCC frameshift_variant&missense_variant 0.21 levofloxacin
moxifloxacin
gyrA 7728 c.427_429delAGGinsCC frameshift_variant&missense_variant 0.25 levofloxacin
moxifloxacin
gyrA 7760 c.459C>T synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 7763 c.462T>C synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7775 c.474C>T synonymous_variant 0.13 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7778 c.477G>T synonymous_variant 0.14 levofloxacin
moxifloxacin
gyrA 8090 c.789C>A synonymous_variant 0.14 levofloxacin
moxifloxacin
gyrA 8099 c.798T>C synonymous_variant 0.13 levofloxacin
moxifloxacin
gyrA 8129 c.828T>C synonymous_variant 0.14 levofloxacin
moxifloxacin
gyrA 8324 c.1023T>C synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 8330 c.1029C>G synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8337 c.1036_1038delCTAinsTG frameshift_variant&stop_gained 0.14 levofloxacin
moxifloxacin
gyrA 8340 p.Ala347Ser missense_variant 0.15 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8372 c.1071G>C synonymous_variant 0.14 levofloxacin
moxifloxacin
gyrA 8375 c.1074G>C synonymous_variant 0.14 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 8382 p.Leu361Met missense_variant 0.14 levofloxacin
moxifloxacin
gyrA 8391 c.1090_1092delTATinsCC frameshift_variant&missense_variant 0.14 levofloxacin
moxifloxacin
gyrA 8399 c.1098T>C synonymous_variant 0.13 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8405 c.1104C>T synonymous_variant 0.12 levofloxacin
moxifloxacin
gyrA 8423 c.1122G>C synonymous_variant 0.13 levofloxacin
moxifloxacin
gyrA 8588 c.1287G>A synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 8619 c.1318T>C synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8624 c.1323G>C synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 8627 c.1326C>G synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 8642 c.1341A>G synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 8655 p.Ile452Val missense_variant 0.16 levofloxacin
moxifloxacin
gyrA 8756 c.1455A>G synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8801 c.1500G>C synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 8810 c.1509A>T synonymous_variant 0.14 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8818 p.Ser506Asn missense_variant 0.15 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8828 c.1527T>C synonymous_variant 0.14 levofloxacin
moxifloxacin
gyrA 8829 c.1528T>C synonymous_variant 0.14 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8897 c.1596T>C synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8903 c.1602T>C synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8909 c.1608C>T synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8930 c.1629C>T synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8939 c.1638T>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8942 c.1641G>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8945 c.1644G>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8946 c.1645T>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8966 c.1665C>G synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8967 p.Ala556Arg missense_variant 0.2 levofloxacin
moxifloxacin
gyrA 8990 c.1689C>G synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8996 c.1695T>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8998 p.Leu566Trp missense_variant 0.23 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9008 c.1707C>T synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 9023 c.1722A>C synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9029 c.1728T>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 9032 c.1731T>C synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 9044 c.1743C>G synonymous_variant 0.13 levofloxacin
moxifloxacin
gyrA 9278 c.1977G>C synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
fgd1 491742 c.960T>C synonymous_variant 1.0 clofazimine Not assoc w R
pretomanid
delamanid Not assoc w R - Interim
mshA 575907 p.Ala187Val missense_variant 1.0 ethionamide Not assoc w R
isoniazid Not assoc w R
ccsA 620625 p.Ile245Met missense_variant 1.0 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Uncertain significance
Rv0565c 657081 c.390G>A synonymous_variant 1.0 ethionamide Not assoc w R - Interim
Rv0565c 657142 p.Arg110His missense_variant 1.0 ethionamide Uncertain significance
rpoB 760085 c.279C>T synonymous_variant 0.12 rifampicin Not assoc w R - Interim
rpoB 760101 c.295T>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 760112 c.306T>C synonymous_variant 0.18 rifampicin
rpoB 760118 c.312T>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760130 p.Asp108Glu missense_variant 0.18 rifampicin Uncertain significance
rpoB 760139 c.333A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760142 c.336C>G synonymous_variant 0.19 rifampicin
rpoB 760181 c.375T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760184 c.378A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760196 c.390C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760235 c.429T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760283 c.477G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760298 c.492G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760310 c.504G>C synonymous_variant 0.18 rifampicin
rpoB 760328 c.522G>C synonymous_variant 0.19 rifampicin
rpoB 760412 c.606C>G synonymous_variant 0.13 rifampicin
rpoB 760547 c.741G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 760563 p.Arg253Met missense_variant 0.15 rifampicin Uncertain significance
rpoB 760591 p.Val262Ala missense_variant 0.16 rifampicin
rpoB 760611 c.805T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760646 c.840C>G synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 761129 c.1323G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 761133 c.1327T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 761147 c.1341C>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 761150 c.1344A>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 761153 c.1347G>C synonymous_variant 0.21 rifampicin
rpoB 761165 c.1359G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 761180 c.1374A>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761564 c.1758G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 761570 c.1764T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 761573 c.1767C>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 761579 c.1773G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 761600 c.1794T>C synonymous_variant 0.28 rifampicin
rpoB 761606 c.1800C>G synonymous_variant 0.28 rifampicin
rpoB 761612 c.1806G>T synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 761615 c.1809A>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 761636 c.1830G>T synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 761645 c.1839C>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 761648 c.1842T>C synonymous_variant 0.32 rifampicin
rpoB 761657 c.1851C>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 761675 c.1869G>C synonymous_variant 0.23 rifampicin
rpoB 761682 c.1876C>T synonymous_variant 0.23 rifampicin
rpoB 761792 c.1986T>C synonymous_variant 0.14 rifampicin
rpoB 761813 c.2007T>C synonymous_variant 0.18 rifampicin
rpoB 761815 p.Ala670Glu missense_variant 0.19 rifampicin
rpoB 761834 c.2028T>C synonymous_variant 0.2 rifampicin
rpoB 761891 c.2085G>C synonymous_variant 0.21 rifampicin
rpoB 761906 c.2100C>G synonymous_variant 0.16 rifampicin
rpoB 761909 c.2103T>C synonymous_variant 0.15 rifampicin
rpoB 761912 c.2106T>C synonymous_variant 0.15 rifampicin
rpoB 761915 p.Asp703Glu missense_variant 0.16 rifampicin
rpoB 761916 p.Asp704Asn missense_variant 0.17 rifampicin
rpoB 761933 c.2127G>C synonymous_variant 0.21 rifampicin
rpoB 761948 c.2142G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761954 c.2148C>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 761969 c.2163G>A synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 762014 c.2208C>T synonymous_variant 0.2 rifampicin
rpoB 762017 c.2211A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 762053 c.2247T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 762062 c.2256T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 762083 c.2277T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 762086 c.2280G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 762101 c.2295C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 762114 p.Ile770Val missense_variant 0.15 rifampicin Uncertain significance
rpoB 762131 c.2325C>G synonymous_variant 0.17 rifampicin
rpoB 762143 c.2337T>C synonymous_variant 0.18 rifampicin
rpoB 762149 c.2343G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 762176 c.2370T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 762185 c.2379G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 762233 c.2427G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 762254 c.2448T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 762329 c.2523G>C synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoB 762929 c.3123G>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 762947 c.-423C>G upstream_gene_variant 0.16 rifampicin
rpoB 762962 c.3156C>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 762983 c.-387C>T upstream_gene_variant 0.16 rifampicin
rpoC 762989 c.-381G>C upstream_gene_variant 0.16 rifampicin
rpoB 762995 c.3189G>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 763028 c.3222T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>C synonymous_variant 1.0 rifampicin Not assoc w R
rpoB 763034 c.3228C>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 763040 c.3234C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 763070 c.3264T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 763085 c.3279C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 763115 c.3309T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 763136 c.3330C>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 763148 c.-222G>C upstream_gene_variant 0.22 rifampicin
rpoC 763158 c.-212C>T upstream_gene_variant 0.23 rifampicin
rpoB 763166 c.3360A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 763528 c.159G>A synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 763573 c.204G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 763576 c.207C>G synonymous_variant 0.29 rifampicin
rpoC 763594 c.225C>T synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 763636 c.267T>C synonymous_variant 0.35 rifampicin
rpoC 763648 c.279C>T synonymous_variant 0.34 rifampicin
rpoC 763660 c.291T>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 763666 c.297G>T synonymous_variant 0.37 rifampicin
rpoC 763675 c.306C>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 763696 c.327T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 763702 c.333C>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 763717 c.348T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 763723 c.354G>C synonymous_variant 0.25 rifampicin
rpoC 763732 c.363C>G synonymous_variant 0.23 rifampicin
rpoC 763735 c.366G>C synonymous_variant 0.23 rifampicin
rpoC 763741 c.372C>T synonymous_variant 0.19 rifampicin
rpoC 763744 c.375G>C synonymous_variant 0.18 rifampicin
rpoC 763765 c.396T>C synonymous_variant 0.17 rifampicin
rpoC 763774 c.405G>C synonymous_variant 0.18 rifampicin
rpoC 763789 c.420C>T synonymous_variant 0.18 rifampicin
rpoC 763807 c.438T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 763819 c.450G>C synonymous_variant 0.14 rifampicin
rpoC 763853 p.Val162Ile missense_variant 0.14 rifampicin
rpoC 763861 c.492C>T synonymous_variant 0.14 rifampicin
rpoC 763872 p.Gly168Ala missense_variant 0.14 rifampicin
rpoC 763879 c.510A>G synonymous_variant 0.14 rifampicin
rpoC 763888 c.519G>C synonymous_variant 0.13 rifampicin
rpoC 764047 c.678C>T synonymous_variant 0.16 rifampicin
rpoC 764059 c.690G>C synonymous_variant 0.18 rifampicin
rpoC 764083 c.714A>G synonymous_variant 0.18 rifampicin
rpoC 764098 c.729A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764101 c.732C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764102 p.Val245Ile missense_variant 0.22 rifampicin
rpoC 764112 p.Tyr248Phe missense_variant 0.22 rifampicin
rpoC 764116 c.747C>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764131 c.762T>C synonymous_variant 0.21 rifampicin
rpoC 764188 c.819A>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 764195 p.Ser276Ile missense_variant 0.25 rifampicin
rpoC 764203 c.834G>T synonymous_variant 0.24 rifampicin
rpoC 764206 c.837T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 764215 c.846A>G synonymous_variant 0.25 rifampicin
rpoC 764257 c.888G>C synonymous_variant 0.24 rifampicin
rpoC 764266 c.897T>C synonymous_variant 0.24 rifampicin
rpoC 764269 c.900G>C synonymous_variant 0.23 rifampicin
rpoC 764278 c.909A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 764293 c.924G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 764461 c.1092A>G synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 764521 c.1152T>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 764536 c.1167G>C synonymous_variant 0.19 rifampicin
rpoC 764539 c.1170C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 764554 c.1185C>T synonymous_variant 0.33 rifampicin
rpoC 764560 c.1191T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 764566 c.1197C>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 764575 c.1206T>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 764578 c.1209C>G synonymous_variant 0.3 rifampicin
rpoC 764593 c.1224C>T synonymous_variant 0.35 rifampicin
rpoC 764611 c.1242G>C synonymous_variant 0.32 rifampicin
rpoC 764626 c.1257C>T synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 764632 c.1263T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764809 c.1440C>T synonymous_variant 0.15 rifampicin Not assoc w R
rpoC 764815 c.1446A>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 764827 c.1458G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764858 c.1489T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764872 c.1503A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764888 c.1519T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764893 c.1524T>C synonymous_variant 0.21 rifampicin
rpoC 764911 c.1542A>G synonymous_variant 0.21 rifampicin
rpoC 764932 c.1563C>A synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764948 c.1579T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 765734 c.2365T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 765751 c.2382C>G synonymous_variant 0.2 rifampicin
rpoC 765753 p.Asp795Ala missense_variant 0.19 rifampicin Uncertain significance
rpoC 766384 c.3015A>G synonymous_variant 0.18 rifampicin
rpoC 766390 c.3021C>T synonymous_variant 0.21 rifampicin
rpoC 766408 c.3039C>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 766426 c.3057C>T synonymous_variant 0.23 rifampicin
rpoC 766447 c.3078T>C synonymous_variant 0.18 rifampicin
rpoC 766645 c.3276A>G synonymous_variant 0.2 rifampicin
rpoC 766657 c.3288A>G synonymous_variant 0.21 rifampicin
rpoC 766672 c.3303T>C synonymous_variant 0.22 rifampicin
rpoC 766726 c.3357T>C synonymous_variant 0.25 rifampicin
rpoC 766738 c.3369G>C synonymous_variant 0.25 rifampicin
rpoC 766741 c.3372G>A synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 766765 c.3396A>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 766774 c.3405T>C synonymous_variant 0.2 rifampicin
rpoC 766777 c.3408C>T synonymous_variant 0.2 rifampicin
rpoC 766861 c.3492G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 766864 c.3495G>C synonymous_variant 0.28 rifampicin
rpoC 766894 c.3525T>C synonymous_variant 0.35 rifampicin
rpoC 766895 c.3526T>C synonymous_variant 0.35 rifampicin
rpoC 766900 c.3531T>C synonymous_variant 0.37 rifampicin
rpoC 766933 c.3564A>G synonymous_variant 0.42 rifampicin
rpoC 766945 c.3576A>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 766963 c.3594T>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 766978 c.3609C>G synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 766996 c.3627C>T synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoC 767035 c.3666G>C synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoC 767059 c.3690T>G synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 767062 c.3693C>A synonymous_variant 0.43 rifampicin
rpoC 767098 c.3729T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 767119 c.3750A>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 767134 c.3765C>A synonymous_variant 0.35 rifampicin
rpoC 767167 c.3798C>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 767180 p.Ala1271Gln missense_variant 0.3 rifampicin
rpoC 767191 c.3822C>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 767206 c.3837C>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 767209 c.3840T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 767212 c.3843G>C synonymous_variant 0.26 rifampicin
rpoC 767221 c.3852C>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
mmpL5 775639 p.Ile948Val missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
mmpL5 776100 p.Thr794Ile missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
mmpL5 776182 p.Asp767Asn missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R
mmpS5 779615 c.-710C>G upstream_gene_variant 1.0 clofazimine
bedaquiline
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
Rv1129c 1254562 c.-28T>C upstream_gene_variant 1.0 moxifloxacin Not assoc w R
levofloxacin Not assoc w R
rifampicin Not assoc w R
isoniazid Not assoc w R
fbiC 1303732 p.Ser268Ala missense_variant 0.14 clofazimine
pretomanid
delamanid
fbiC 1303746 c.816T>C synonymous_variant 0.15 clofazimine
pretomanid
delamanid
fbiC 1303749 c.819G>C synonymous_variant 0.15 clofazimine
pretomanid
delamanid
fbiC 1303752 c.822A>G synonymous_variant 0.14 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1303761 c.831T>C synonymous_variant 0.15 clofazimine
pretomanid
delamanid
fbiC 1303768 p.Ser280Ala missense_variant 0.15 clofazimine
pretomanid
delamanid
fbiC 1303785 c.855G>T synonymous_variant 0.14 clofazimine
pretomanid
delamanid
fbiC 1303797 c.867A>G synonymous_variant 0.15 clofazimine
pretomanid
delamanid
fbiC 1303818 c.888C>G synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1303854 c.924T>C synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1303860 c.930A>C synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1303884 c.954T>G synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1303890 c.960G>C synonymous_variant 0.15 clofazimine
pretomanid
delamanid
fbiC 1303896 c.966G>C synonymous_variant 0.13 clofazimine
pretomanid
delamanid
fbiC 1303902 c.972G>C synonymous_variant 0.13 clofazimine
pretomanid
delamanid
fbiC 1304634 c.1704C>G synonymous_variant 0.14 clofazimine
pretomanid
delamanid
fbiC 1304640 c.1710A>C synonymous_variant 0.14 clofazimine
pretomanid
delamanid
fbiC 1304646 c.1716T>C synonymous_variant 0.15 clofazimine
pretomanid
delamanid
fbiC 1304655 c.1725C>T synonymous_variant 0.13 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1304893 p.Gly655Ser missense_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1304904 c.1974G>A synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1304916 c.1986T>C synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1304922 c.1992C>T synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1304928 c.1998T>C synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1304937 c.2007G>C synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1304940 c.2010A>G synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1304946 c.2016G>C synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1304958 c.2028T>G synonymous_variant 0.25 clofazimine
pretomanid
delamanid
Rv1258c 1406760 c.580_581insC frameshift_variant 1.0 streptomycin Uncertain significance
isoniazid Uncertain significance
pyrazinamide Uncertain significance
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrl 1473752 n.95G>A non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1473756 n.99G>A non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1473758 n.101G>T non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid
rrl 1473806 n.149C>T non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473813 n.156C>T non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1474111 n.454T>C non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1474140 n.483C>T non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474181 n.524C>T non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474282 n.625G>A non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid
rrl 1474291 n.634_649delTTTCCTCTCCGGAGGAinsC non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1474308 n.651G>T non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474310 n.653T>G non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1474356 n.699T>C non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid
rrl 1474362 n.705A>G non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474376 n.719T>C non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1474427 n.770A>C non_coding_transcript_exon_variant 0.14 capreomycin
linezolid
rrl 1474429 n.772G>C non_coding_transcript_exon_variant 0.15 capreomycin
linezolid
rrl 1474431 n.774_775delGCinsTTTGGG non_coding_transcript_exon_variant 0.15 capreomycin
linezolid
rrl 1474639 n.982G>A non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474823 n.1166C>T non_coding_transcript_exon_variant 0.39 capreomycin
linezolid
rrl 1474831 n.1174A>G non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid
rrl 1474904 n.1247G>A non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1475061 n.1404C>T non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid
rrl 1475088 n.1431A>T non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1475266 n.1609T>C non_coding_transcript_exon_variant 0.13 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475275 n.1618C>T non_coding_transcript_exon_variant 0.14 capreomycin
linezolid
rrl 1475276 n.1619T>C non_coding_transcript_exon_variant 0.14 capreomycin
linezolid
rrl 1475291 n.1634A>C non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475315 n.1658A>T non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475355 n.1698C>T non_coding_transcript_exon_variant 0.14 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475483 n.1826C>T non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475505 n.1848G>A non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475761 n.2104_2106delCGCinsGT non_coding_transcript_exon_variant 0.31 capreomycin
linezolid
rrl 1475765 n.2111delG non_coding_transcript_exon_variant 0.32 capreomycin
linezolid
rrl 1475881 n.2224T>C non_coding_transcript_exon_variant 0.31 capreomycin
linezolid
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.26 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476045 n.2388G>T non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid
rrl 1476047 n.2390G>T non_coding_transcript_exon_variant 0.14 capreomycin
linezolid
rrl 1476048 n.2391G>A non_coding_transcript_exon_variant 0.14 capreomycin
linezolid
rrl 1476049 n.2392C>T non_coding_transcript_exon_variant 0.14 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476214 n.2557G>T non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476215 n.2558C>T non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476297 n.2640C>T non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476299 n.2642C>T non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476583 n.2926G>A non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.28 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476597 n.2940G>A non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid
rrl 1476608 n.2951C>G non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476689 n.3032A>T non_coding_transcript_exon_variant 0.27 capreomycin
linezolid
rrl 1476690 n.3033C>T non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid
rrl 1476693 n.3036G>A non_coding_transcript_exon_variant 0.27 capreomycin
linezolid
rrl 1476695 n.3038T>A non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1476716 n.3059A>C non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid
rrl 1476726 n.3069A>G non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1476732 n.3075T>C non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
inhA 1674537 c.336C>A synonymous_variant 0.13 ethionamide
isoniazid
inhA 1674542 p.Ala114Glu missense_variant 0.13 ethionamide
isoniazid
inhA 1674555 c.354G>A synonymous_variant 0.13 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
inhA 1674561 c.360C>T synonymous_variant 0.14 ethionamide
isoniazid
inhA 1674903 c.702T>C synonymous_variant 0.14 ethionamide
isoniazid
inhA 1674904 p.Ala235Pro missense_variant 0.15 ethionamide
isoniazid
inhA 1674909 c.708G>C synonymous_variant 0.15 ethionamide
isoniazid
inhA 1674939 c.738G>C synonymous_variant 0.14 ethionamide
isoniazid
inhA 1674942 c.741T>G synonymous_variant 0.14 ethionamide
isoniazid
rpsA 1833554 p.Thr5Ala missense_variant 0.17 pyrazinamide Uncertain significance
rpsA 1833589 c.48A>T synonymous_variant 0.21 pyrazinamide
rpsA 1833595 c.54T>G synonymous_variant 0.23 pyrazinamide
rpsA 1833604 c.63C>T synonymous_variant 0.23 pyrazinamide
rpsA 1833667 c.126C>G synonymous_variant 0.28 pyrazinamide
rpsA 1833703 c.162C>T synonymous_variant 0.26 pyrazinamide Not assoc w R - Interim
rpsA 1833724 c.183C>G synonymous_variant 0.22 pyrazinamide
rpsA 1833727 c.186G>C synonymous_variant 0.24 pyrazinamide
rpsA 1833745 c.204G>C synonymous_variant 0.22 pyrazinamide
rpsA 1833760 c.219C>T synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
rpsA 1833874 c.333T>C synonymous_variant 0.22 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.25 pyrazinamide
rpsA 1833940 c.399C>G synonymous_variant 0.29 pyrazinamide
rpsA 1833976 c.435C>T synonymous_variant 0.24 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.25 pyrazinamide
rpsA 1833994 c.453G>A synonymous_variant 0.28 pyrazinamide
rpsA 1834009 c.468C>T synonymous_variant 0.24 pyrazinamide
rpsA 1834012 c.471G>C synonymous_variant 0.23 pyrazinamide
rpsA 1834015 c.474G>C synonymous_variant 0.22 pyrazinamide
rpsA 1834021 c.480C>T synonymous_variant 0.23 pyrazinamide
rpsA 1834030 c.489C>G synonymous_variant 0.2 pyrazinamide
rpsA 1834097 c.556_557delTCinsAG synonymous_variant 0.2 pyrazinamide
rpsA 1834102 c.561T>C synonymous_variant 0.21 pyrazinamide
rpsA 1834108 c.567C>G synonymous_variant 0.21 pyrazinamide
rpsA 1834114 c.573G>C synonymous_variant 0.19 pyrazinamide
rpsA 1834150 c.609G>C synonymous_variant 0.15 pyrazinamide
rpsA 1834153 c.612T>C synonymous_variant 0.14 pyrazinamide
rpsA 1834154 p.Asn205His missense_variant 0.14 pyrazinamide
rpsA 1834157 c.616T>C synonymous_variant 0.14 pyrazinamide
rpsA 1834162 c.621A>G synonymous_variant 0.15 pyrazinamide Not assoc w R - Interim
rpsA 1834165 c.624A>G synonymous_variant 0.15 pyrazinamide
rpsA 1834169 p.Thr210Ala missense_variant 0.15 pyrazinamide Uncertain significance
rpsA 1834177 c.636A>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
rpsA 1834189 c.648G>C synonymous_variant 0.18 pyrazinamide
rpsA 1834210 c.669C>T synonymous_variant 0.19 pyrazinamide
rpsA 1834213 c.672G>A synonymous_variant 0.18 pyrazinamide
rpsA 1834222 c.681T>C synonymous_variant 0.18 pyrazinamide
rpsA 1834228 c.687C>T synonymous_variant 0.17 pyrazinamide
rpsA 1834231 c.690T>G synonymous_variant 0.16 pyrazinamide
rpsA 1834294 c.753G>C synonymous_variant 0.3 pyrazinamide
rpsA 1834303 c.762T>C synonymous_variant 0.31 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.32 pyrazinamide
rpsA 1834345 c.804C>T synonymous_variant 0.28 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 0.28 pyrazinamide Not assoc w R - Interim
rpsA 1834366 c.825A>G synonymous_variant 0.3 pyrazinamide Not assoc w R - Interim
rpsA 1834369 c.828C>G synonymous_variant 0.29 pyrazinamide
rpsA 1834396 c.855G>C synonymous_variant 0.28 pyrazinamide
rpsA 1834408 c.867C>T synonymous_variant 0.28 pyrazinamide
rpsA 1834411 c.870T>C synonymous_variant 0.29 pyrazinamide
rpsA 1834417 c.876G>C synonymous_variant 0.28 pyrazinamide
rpsA 1834423 c.882G>C synonymous_variant 0.28 pyrazinamide
rpsA 1834435 c.894G>C synonymous_variant 0.22 pyrazinamide
rpsA 1834451 c.910T>C synonymous_variant 0.14 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.15 pyrazinamide
rpsA 1834474 c.933C>G synonymous_variant 0.14 pyrazinamide
rpsA 1834489 c.948T>C synonymous_variant 0.16 pyrazinamide
rpsA 1834540 c.999G>C synonymous_variant 0.25 pyrazinamide
rpsA 1834609 c.1068T>C synonymous_variant 0.2 pyrazinamide
rpsA 1834612 c.1071G>A synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
rpsA 1834633 c.1092A>G synonymous_variant 0.2 pyrazinamide
rpsA 1834639 c.1098T>C synonymous_variant 0.22 pyrazinamide
rpsA 1834654 c.1113G>A synonymous_variant 0.18 pyrazinamide
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
katG 2154724 p.Arg463Leu missense_variant 1.0 isoniazid Not assoc w R
PPE35 2167926 p.Leu896Ser missense_variant 1.0 pyrazinamide Not assoc w R
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
kasA 2518190 p.Ser26Ala missense_variant 0.15 isoniazid
kasA 2518248 p.Ala45Val missense_variant 0.13 isoniazid
kasA 2518504 c.390T>C synonymous_variant 0.15 isoniazid
kasA 2518506 p.Ala131Glu missense_variant 0.15 isoniazid
kasA 2518519 c.405G>C synonymous_variant 0.17 isoniazid
kasA 2518528 c.414C>G synonymous_variant 0.19 isoniazid
kasA 2518534 c.420G>C synonymous_variant 0.2 isoniazid
kasA 2518561 c.447T>C synonymous_variant 0.18 isoniazid
kasA 2518574 c.460_462delATCinsGG frameshift_variant&missense_variant 0.2 isoniazid
kasA 2518579 c.465T>C synonymous_variant 0.19 isoniazid
kasA 2518588 c.474T>G synonymous_variant 0.23 isoniazid
kasA 2518591 c.477G>C synonymous_variant 0.23 isoniazid
kasA 2518609 p.Met165Ile missense_variant 0.25 isoniazid
kasA 2518624 c.510C>G synonymous_variant 0.28 isoniazid
kasA 2518627 c.513T>C synonymous_variant 0.28 isoniazid
kasA 2518633 c.519G>C synonymous_variant 0.28 isoniazid
kasA 2518642 c.528A>G synonymous_variant 0.25 isoniazid
kasA 2518651 c.537C>G synonymous_variant 0.25 isoniazid
kasA 2518663 c.549T>C synonymous_variant 0.25 isoniazid
kasA 2518671 p.Val186Ala missense_variant 0.22 isoniazid
kasA 2518678 c.564C>T synonymous_variant 0.25 isoniazid
kasA 2518687 c.573C>T synonymous_variant 0.24 isoniazid
kasA 2518688 p.Val192Phe missense_variant 0.24 isoniazid
kasA 2518705 c.591T>G synonymous_variant 0.27 isoniazid
kasA 2518711 c.597A>G synonymous_variant 0.28 isoniazid
kasA 2518714 c.600A>T synonymous_variant 0.29 isoniazid
kasA 2518732 c.618C>G synonymous_variant 0.31 isoniazid
kasA 2518765 c.651G>C synonymous_variant 0.26 isoniazid
kasA 2518768 c.654C>T synonymous_variant 0.27 isoniazid
kasA 2518783 c.669T>C synonymous_variant 0.29 isoniazid
kasA 2518789 c.675G>C synonymous_variant 0.29 isoniazid
kasA 2518792 c.678C>A synonymous_variant 0.29 isoniazid
kasA 2518795 c.681C>G synonymous_variant 0.27 isoniazid
kasA 2518825 c.711T>C synonymous_variant 0.26 isoniazid
kasA 2518843 c.729T>G synonymous_variant 0.22 isoniazid
kasA 2518846 c.732G>C synonymous_variant 0.22 isoniazid
kasA 2518853 p.Leu247Ile missense_variant 0.2 isoniazid
kasA 2518864 c.750G>C synonymous_variant 0.18 isoniazid
kasA 2518879 c.765A>G synonymous_variant 0.13 isoniazid
Rv2477c 2783002 c.1041T>C synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783008 c.1035C>G synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783013 c.1030T>C synonymous_variant 0.17 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783015 p.Ser343Thr missense_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783020 c.1023G>C synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783035 c.1008G>C synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783040 p.Ala335Thr missense_variant 0.23 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
kanamycin Uncertain significance
rifampicin Uncertain significance
amikacin Uncertain significance
Rv2477c 2783044 c.999G>C synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783059 c.984T>C synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783077 c.966T>C synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783092 c.951A>G synonymous_variant 0.17 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783095 c.948C>G synonymous_variant 0.17 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R
amikacin Not assoc w R - Interim
Rv2477c 2783098 c.945C>G synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783101 c.942G>T synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783116 c.927T>C synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783140 c.903C>G synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783149 c.894G>C synonymous_variant 0.25 ethambutol
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783158 c.885A>C synonymous_variant 0.28 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783182 c.861C>G synonymous_variant 0.38 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783185 c.858G>C synonymous_variant 0.41 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783194 c.849A>G synonymous_variant 0.39 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783221 c.822G>C synonymous_variant 0.31 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783224 c.819C>G synonymous_variant 0.3 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783230 c.813T>G synonymous_variant 0.31 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783235 c.808T>C synonymous_variant 0.31 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783244 p.Thr267Ala missense_variant 0.32 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783263 c.780G>C synonymous_variant 0.3 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783278 c.765A>G synonymous_variant 0.3 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783284 c.759G>C synonymous_variant 0.32 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783289 p.Leu252Ile missense_variant 0.31 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783299 c.744A>G synonymous_variant 0.31 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783302 c.741A>G synonymous_variant 0.31 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783311 c.732T>C synonymous_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783317 c.726G>C synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783332 c.711T>C synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783335 c.708C>G synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783350 c.693T>C synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783353 c.690T>C synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783359 c.684G>A synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783362 c.681G>C synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783374 c.669G>C synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783395 c.648T>G synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783860 c.183T>C synonymous_variant 0.15 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
pepQ 2859789 c.630G>C synonymous_variant 0.19 clofazimine
bedaquiline
pepQ 2859792 c.627C>T synonymous_variant 0.18 clofazimine
bedaquiline
pepQ 2859801 c.618G>C synonymous_variant 0.18 clofazimine
bedaquiline
pepQ 2859804 c.615C>T synonymous_variant 0.18 clofazimine
bedaquiline
pepQ 2859813 c.606C>T synonymous_variant 0.19 clofazimine
bedaquiline
pepQ 2859834 c.585T>C synonymous_variant 0.23 clofazimine Not assoc w R - Interim
bedaquiline Not assoc w R - Interim
pepQ 2859843 c.576G>C synonymous_variant 0.24 clofazimine
bedaquiline
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
Rv3236c 3612813 p.Thr102Ala missense_variant 1.0 pyrazinamide Not assoc w R - Interim
mtrB 3625065 p.Met517Leu missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
mtrB 3626562 p.Pro18Ser missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
rpoA 3877656 c.852T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoA 3877677 p.Ala277Ser missense_variant 0.18 rifampicin
rpoA 3877680 c.828G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3877686 c.822A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3877692 c.816G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3877704 c.804G>C synonymous_variant 0.17 rifampicin
rpoA 3877731 c.777G>C synonymous_variant 0.17 rifampicin
rpoA 3877743 c.765T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoA 3877764 c.744C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3877770 c.738A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3877776 c.732T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoA 3877782 c.726T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
clpC1 4038498 p.Ser736Asn missense_variant 0.14 pyrazinamide
clpC1 4038519 p.Arg729Gln missense_variant 0.13 pyrazinamide
clpC1 4038534 p.Arg724Asn missense_variant 0.14 pyrazinamide
clpC1 4038596 c.2109A>G synonymous_variant 0.14 pyrazinamide
clpC1 4038623 c.2082A>G synonymous_variant 0.14 pyrazinamide
clpC1 4038640 p.Asp689Asn missense_variant 0.19 pyrazinamide
clpC1 4038653 c.2052C>T synonymous_variant 0.19 pyrazinamide
clpC1 4038658 p.Lys683Gln missense_variant 0.18 pyrazinamide
clpC1 4038661 p.Ser682Thr missense_variant 0.17 pyrazinamide
clpC1 4038662 c.2043T>C synonymous_variant 0.18 pyrazinamide
clpC1 4038671 c.2034T>C synonymous_variant 0.21 pyrazinamide
clpC1 4038674 c.2031C>G synonymous_variant 0.22 pyrazinamide
clpC1 4038683 c.2022T>C synonymous_variant 0.21 pyrazinamide Not assoc w R - Interim
clpC1 4038693 p.Ser671Gly missense_variant 0.21 pyrazinamide
clpC1 4038701 c.2004G>C synonymous_variant 0.22 pyrazinamide
clpC1 4038704 c.2001T>C synonymous_variant 0.22 pyrazinamide
clpC1 4038707 c.1998C>G synonymous_variant 0.22 pyrazinamide
clpC1 4038710 c.1995G>C synonymous_variant 0.21 pyrazinamide
clpC1 4038713 c.1992T>C synonymous_variant 0.21 pyrazinamide
clpC1 4038740 c.1965G>C synonymous_variant 0.25 pyrazinamide
clpC1 4038755 c.1950G>T synonymous_variant 0.22 pyrazinamide
clpC1 4038773 c.1932T>C synonymous_variant 0.19 pyrazinamide
clpC1 4038782 c.1923G>C synonymous_variant 0.19 pyrazinamide
clpC1 4038790 c.1915C>T synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
clpC1 4038812 c.1893T>C synonymous_variant 0.22 pyrazinamide
clpC1 4038815 c.1890G>C synonymous_variant 0.23 pyrazinamide
clpC1 4038878 c.1827A>G synonymous_variant 0.24 pyrazinamide Not assoc w R - Interim
clpC1 4038908 c.1797C>G synonymous_variant 0.27 pyrazinamide
clpC1 4038914 c.1791G>C synonymous_variant 0.28 pyrazinamide
clpC1 4038923 c.1780_1782delCTAinsTG frameshift_variant&synonymous_variant 0.27 pyrazinamide
clpC1 4038953 c.1752A>G synonymous_variant 0.23 pyrazinamide
clpC1 4038965 c.1740T>C synonymous_variant 0.22 pyrazinamide
clpC1 4038971 c.1734T>C synonymous_variant 0.21 pyrazinamide
clpC1 4038974 c.1731T>C synonymous_variant 0.21 pyrazinamide Not assoc w R - Interim
clpC1 4038989 c.1716T>C synonymous_variant 0.27 pyrazinamide
clpC1 4038997 c.1708T>C synonymous_variant 0.26 pyrazinamide Not assoc w R - Interim
clpC1 4039010 c.1695G>A synonymous_variant 0.3 pyrazinamide
clpC1 4039022 c.1683A>G synonymous_variant 0.29 pyrazinamide
clpC1 4039064 c.1641C>T synonymous_variant 0.3 pyrazinamide
clpC1 4039103 c.1602T>C synonymous_variant 0.37 pyrazinamide
clpC1 4039106 c.1599G>C synonymous_variant 0.36 pyrazinamide
clpC1 4039112 c.1593C>G synonymous_variant 0.37 pyrazinamide
clpC1 4039115 c.1590G>A synonymous_variant 0.38 pyrazinamide Not assoc w R - Interim
clpC1 4039121 c.1584T>C synonymous_variant 0.39 pyrazinamide
clpC1 4039142 c.1563A>G synonymous_variant 0.37 pyrazinamide
clpC1 4039145 c.1560G>C synonymous_variant 0.38 pyrazinamide
clpC1 4039169 p.Glu512Asp missense_variant 0.35 pyrazinamide
clpC1 4039172 c.1533A>G synonymous_variant 0.35 pyrazinamide
clpC1 4039178 c.1527G>C synonymous_variant 0.36 pyrazinamide
clpC1 4039183 c.1522T>C synonymous_variant 0.36 pyrazinamide
clpC1 4039187 c.1518G>C synonymous_variant 0.34 pyrazinamide
clpC1 4039226 c.1479T>C synonymous_variant 0.22 pyrazinamide Not assoc w R - Interim
clpC1 4039274 c.1431G>C synonymous_variant 0.16 pyrazinamide Not assoc w R - Interim
clpC1 4039286 c.1419T>C synonymous_variant 0.15 pyrazinamide
clpC1 4039295 c.1410A>G synonymous_variant 0.17 pyrazinamide
clpC1 4039298 c.1407T>C synonymous_variant 0.16 pyrazinamide
clpC1 4039319 c.1386T>C synonymous_variant 0.15 pyrazinamide Not assoc w R - Interim
clpC1 4039322 c.1383T>C synonymous_variant 0.14 pyrazinamide
clpC1 4039328 p.Ala459Gly missense_variant 0.14 pyrazinamide
clpC1 4039331 c.1374C>G synonymous_variant 0.14 pyrazinamide
clpC1 4039338 p.Thr456Gln missense_variant 0.15 pyrazinamide
clpC1 4039346 c.1359G>C synonymous_variant 0.19 pyrazinamide
clpC1 4039361 c.1344C>G synonymous_variant 0.23 pyrazinamide
clpC1 4039391 c.1314T>G synonymous_variant 0.29 pyrazinamide
clpC1 4039409 c.1296T>C synonymous_variant 0.31 pyrazinamide
clpC1 4039412 c.1293T>G synonymous_variant 0.31 pyrazinamide
glpK 4139321 c.435T>C synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139324 c.432A>C synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139330 c.426G>C synonymous_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139351 c.405C>T synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139356 p.Leu134Val missense_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139359 p.Asn133Asp missense_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139360 c.396A>C synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139363 c.393T>C synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139372 c.384A>C synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139378 c.376_378delCTGinsGC frameshift_variant&missense_variant 0.14 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
glpK 4139387 c.369G>C synonymous_variant 0.14 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139390 c.366C>T synonymous_variant 0.14 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139408 c.348T>C synonymous_variant 0.14 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139600 c.156G>C synonymous_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139627 c.129G>A synonymous_variant 0.21 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4139630 c.126C>T synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139636 c.120C>T synonymous_variant 0.18 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4139653 p.His35Asp missense_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
embC 4242643 c.2781C>T synonymous_variant 0.93 ethambutol Not assoc w R
embA 4243460 c.228C>T synonymous_variant 1.0 ethambutol Not assoc w R
embB 4247437 c.924A>G synonymous_variant 0.16 ethambutol Not assoc w R - Interim
embB 4247440 c.927C>G synonymous_variant 0.16 ethambutol
embB 4247446 c.933C>T synonymous_variant 0.16 ethambutol
embB 4247464 c.951C>G synonymous_variant 0.14 ethambutol
embB 4247470 c.957T>C synonymous_variant 0.14 ethambutol
embB 4247485 c.972C>T synonymous_variant 0.14 ethambutol
embB 4247491 c.978G>C synonymous_variant 0.15 ethambutol
embB 4247497 c.984T>C synonymous_variant 0.16 ethambutol
embB 4247512 c.999T>C synonymous_variant 0.15 ethambutol
aftB 4267647 p.Asp397Gly missense_variant 1.0 ethambutol Not assoc w R
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 capreomycin
amikacin
kanamycin
gid 4407588 c.615A>G synonymous_variant 1.0 streptomycin Not assoc w R
gid 4407927 p.Glu92Asp missense_variant 0.98 streptomycin Not assoc w R