TB-Profiler result

Run: ERR13267017
Summary

Run ID: ERR13267017

Sample name:

Date: 2025-02-11T16:27:32.119408

Number of reads: 1925348

Percentage reads mapped: 86.5

Median coverage: 54.0

Strain: lineage2.2.1

Spoligotype:

Drug-resistance: Pre-XDR-TB

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage2 East-Asian RD105 0.98
La1.2.BCG M.bovis None 0.07
lineage2.2.1 East-Asian (Beijing) RD105;RD207;RD181 0.99
lineage2.2 East-Asian (Beijing) RD105;RD207 0.98
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin rpoB p.Ser450Leu Assoc w R
isoniazid katG p.Ser315Thr Assoc w R High-level resistance
ethambutol embB p.Gln497Arg Assoc w R
pyrazinamide pncA c.-11A>C Assoc w R
streptomycin rpsL p.Lys43Arg Assoc w R
rrs n.462C>T Uncertain significance Mutation from literature
fluoroquinolones
moxifloxacin gyrA p.Asp94Gly Assoc w R High-level resistance
ofloxacin
levofloxacin gyrA p.Asp94Gly Assoc w R
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide ethA c.1265delC Assoc w R
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
gyrA 7582 p.Asp94Gly missense_variant 1.0 levofloxacin Assoc w R
moxifloxacin Assoc w R High-level resistance
rpoB 761155 p.Ser450Leu missense_variant 0.7 rifampicin Assoc w R
rpsL 781687 p.Lys43Arg missense_variant 0.63 streptomycin Assoc w R
rrs 1472307 n.462C>T non_coding_transcript_exon_variant 0.24 streptomycin Uncertain significance Mutation from literature
katG 2155168 p.Ser315Thr missense_variant 0.95 isoniazid Assoc w R High-level resistance
pncA 2289252 c.-11A>C upstream_gene_variant 0.95 pyrazinamide Assoc w R
embB 4248003 p.Gln497Arg missense_variant 0.79 ethambutol Assoc w R
ethA 4326208 c.1265delC frameshift_variant 0.91 ethionamide Assoc w R
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9304 p.Gly668Asp missense_variant 0.98 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
fgd1 491232 c.450T>C synonymous_variant 0.18 pretomanid
delamanid
clofazimine
fgd1 491241 p.Asp153Glu missense_variant 0.17 pretomanid
delamanid
clofazimine
fgd1 491742 c.960T>C synonymous_variant 1.0 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R
mshA 575907 p.Ala187Val missense_variant 1.0 isoniazid Not assoc w R
ethionamide Not assoc w R
ccsA 619507 c.-384A>G upstream_gene_variant 0.28 kanamycin
capreomycin
amikacin
ccsA 619528 c.-363C>G upstream_gene_variant 0.28 kanamycin
capreomycin
amikacin
ccsA 619531 c.-360T>C upstream_gene_variant 0.28 kanamycin
capreomycin
amikacin
ccsA 619535 c.-356_-354delCAAinsGCG upstream_gene_variant 0.28 kanamycin
capreomycin
amikacin
ccsA 619543 c.-348C>G upstream_gene_variant 0.3 kanamycin
capreomycin
amikacin
ccsA 619552 c.-339A>G upstream_gene_variant 0.33 kanamycin
capreomycin
amikacin
ccsA 619555 c.-336C>G upstream_gene_variant 0.32 kanamycin
capreomycin
amikacin
ccsA 619561 c.-330G>C upstream_gene_variant 0.37 kanamycin
capreomycin
amikacin
ccsA 619570 c.-321G>C upstream_gene_variant 0.41 kanamycin
capreomycin
amikacin
ccsA 619574 c.-317G>A upstream_gene_variant 0.4 kanamycin
capreomycin
amikacin
ccsA 619579 c.-312G>C upstream_gene_variant 0.42 kanamycin
capreomycin
amikacin
ccsA 619584 c.-307A>T upstream_gene_variant 0.46 kanamycin
capreomycin
amikacin
ccsA 619591 c.-300G>C upstream_gene_variant 0.46 kanamycin
capreomycin
amikacin
ccsA 619609 c.-282G>C upstream_gene_variant 0.39 kanamycin
capreomycin
amikacin
ccsA 619634 c.-257T>A upstream_gene_variant 0.31 kanamycin
capreomycin
amikacin
ccsA 619645 c.-246G>C upstream_gene_variant 0.27 kanamycin
capreomycin
amikacin
ccsA 619654 c.-237A>G upstream_gene_variant 0.2 kanamycin
capreomycin
amikacin
ccsA 619668 c.-223_-222delCGinsGC upstream_gene_variant 0.19 kanamycin
capreomycin
amikacin
ccsA 619672 c.-219A>T upstream_gene_variant 0.19 kanamycin
capreomycin
amikacin
ccsA 619676 c.-215C>G upstream_gene_variant 0.19 kanamycin
capreomycin
amikacin
ccsA 620283 c.393T>C synonymous_variant 0.16 kanamycin
capreomycin
amikacin
ccsA 620284 p.Ala132Pro missense_variant 0.15 kanamycin
capreomycin
amikacin
ccsA 620288 p.Arg133Gln missense_variant 0.17 kanamycin
capreomycin
amikacin
ccsA 620295 c.405G>T synonymous_variant 0.16 kanamycin
capreomycin
amikacin
ccsA 620298 c.408G>C synonymous_variant 0.16 kanamycin
capreomycin
amikacin
ccsA 620310 c.420C>T synonymous_variant 0.18 kanamycin
capreomycin
amikacin
ccsA 620317 p.Val143Leu missense_variant 0.19 kanamycin
capreomycin
amikacin
ccsA 620340 c.450C>G synonymous_variant 0.22 kanamycin
capreomycin
amikacin
ccsA 620346 c.456C>G synonymous_variant 0.22 kanamycin
capreomycin
amikacin
ccsA 620362 p.Ala158Thr missense_variant 0.27 kanamycin
capreomycin
amikacin
ccsA 620367 c.477T>C synonymous_variant 0.27 kanamycin
capreomycin
amikacin
ccsA 620373 c.483C>G synonymous_variant 0.27 kanamycin
capreomycin
amikacin
ccsA 620376 c.486G>C synonymous_variant 0.29 kanamycin
capreomycin
amikacin
ccsA 620385 c.495G>C synonymous_variant 0.28 kanamycin
capreomycin
amikacin
ccsA 620388 c.498A>G synonymous_variant 0.27 kanamycin
capreomycin
amikacin
ccsA 620389 c.499C>T synonymous_variant 0.27 kanamycin
capreomycin
amikacin
ccsA 620412 c.522T>C synonymous_variant 0.22 kanamycin
capreomycin
amikacin
ccsA 620415 c.525T>C synonymous_variant 0.22 kanamycin Not assoc w R - Interim
capreomycin Not assoc w R - Interim
amikacin Not assoc w R - Interim
ccsA 620421 c.531G>C synonymous_variant 0.22 kanamycin
capreomycin
amikacin
ccsA 620424 c.534G>C synonymous_variant 0.22 kanamycin
capreomycin
amikacin
ccsA 620433 c.543C>G synonymous_variant 0.21 kanamycin Not assoc w R - Interim
capreomycin Not assoc w R - Interim
amikacin Not assoc w R - Interim
ccsA 620436 c.546T>A synonymous_variant 0.21 kanamycin
capreomycin
amikacin
ccsA 620439 c.549T>C synonymous_variant 0.21 kanamycin
capreomycin
amikacin
ccsA 620445 c.555A>G synonymous_variant 0.21 kanamycin
capreomycin
amikacin
ccsA 620460 c.570T>G synonymous_variant 0.19 kanamycin
capreomycin
amikacin
ccsA 620461 p.Val191Ile missense_variant 0.19 kanamycin
capreomycin
amikacin
ccsA 620569 p.Gly227Arg missense_variant 0.15 kanamycin
capreomycin
amikacin
ccsA 620598 c.708C>G synonymous_variant 0.16 kanamycin
capreomycin
amikacin
ccsA 620601 c.711C>T synonymous_variant 0.16 kanamycin
capreomycin
amikacin
ccsA 620604 c.714C>G synonymous_variant 0.16 kanamycin
capreomycin
amikacin
ccsA 620607 c.717T>C synonymous_variant 0.16 kanamycin
capreomycin
amikacin
ccsA 620613 c.723C>G synonymous_variant 0.15 kanamycin
capreomycin
amikacin
ccsA 620622 c.732G>C synonymous_variant 0.17 kanamycin
capreomycin
amikacin
ccsA 620625 p.Ile245Met missense_variant 0.93 kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
ccsA 620631 c.741T>G synonymous_variant 0.2 kanamycin
capreomycin
amikacin
ccsA 620646 c.756G>A synonymous_variant 0.25 kanamycin
capreomycin
amikacin
ccsA 620649 c.759A>G synonymous_variant 0.26 kanamycin
capreomycin
amikacin
ccsA 620659 c.769_771delCGCinsAGG synonymous_variant 0.25 kanamycin
capreomycin
amikacin
ccsA 620664 c.774C>T synonymous_variant 0.24 kanamycin
capreomycin
amikacin
ccsA 620682 c.792G>A synonymous_variant 0.32 kanamycin
capreomycin
amikacin
ccsA 620688 c.798G>C synonymous_variant 0.33 kanamycin
capreomycin
amikacin
ccsA 620710 p.Val274Ile missense_variant 0.32 kanamycin
capreomycin
amikacin
ccsA 620718 c.828G>C synonymous_variant 0.3 kanamycin
capreomycin
amikacin
ccsA 620721 c.831G>C synonymous_variant 0.31 kanamycin
capreomycin
amikacin
ccsA 620733 c.843G>C synonymous_variant 0.3 kanamycin
capreomycin
amikacin
ccsA 620734 c.844C>A synonymous_variant 0.3 kanamycin
capreomycin
amikacin
ccsA 620739 c.849A>G synonymous_variant 0.28 kanamycin
capreomycin
amikacin
ccsA 620742 c.852G>C synonymous_variant 0.29 kanamycin
capreomycin
amikacin
ccsA 620745 c.855G>C synonymous_variant 0.28 kanamycin
capreomycin
amikacin
ccsA 620748 c.858T>A synonymous_variant 0.28 kanamycin
capreomycin
amikacin
ccsA 620763 c.873G>A synonymous_variant 0.29 kanamycin
capreomycin
amikacin
ccsA 620769 c.879C>G synonymous_variant 0.27 kanamycin Not assoc w R - Interim
capreomycin Not assoc w R - Interim
amikacin Not assoc w R - Interim
ccsA 620778 c.888T>C synonymous_variant 0.25 kanamycin
capreomycin
amikacin
ccsA 620784 c.894C>G synonymous_variant 0.23 kanamycin
capreomycin
amikacin
ccsA 620790 c.900C>T synonymous_variant 0.23 kanamycin
capreomycin
amikacin
ccsA 620796 c.906C>G synonymous_variant 0.19 kanamycin
capreomycin
amikacin
ccsA 620809 c.919C>T synonymous_variant 0.19 kanamycin
capreomycin
amikacin
ccsA 620823 c.933C>T synonymous_variant 0.14 kanamycin
capreomycin
amikacin
Rv0565c 656412 c.1059T>G synonymous_variant 0.15 ethionamide
Rv0565c 656418 c.1053A>G synonymous_variant 0.14 ethionamide
Rv0565c 656423 c.1048T>C synonymous_variant 0.16 ethionamide
Rv0565c 657081 c.390G>A synonymous_variant 1.0 ethionamide Not assoc w R - Interim
Rv0565c 657142 p.Arg110His missense_variant 0.98 ethionamide Uncertain significance
Rv0565c 657671 c.-201A>G upstream_gene_variant 0.19 ethionamide
Rv0565c 657678 c.-209_-208delAAinsTC upstream_gene_variant 0.17 ethionamide
Rv0565c 657689 c.-220_-219delCAinsAC upstream_gene_variant 0.21 ethionamide
Rv0565c 657701 c.-231C>G upstream_gene_variant 0.24 ethionamide
Rv0565c 657734 c.-264T>C upstream_gene_variant 0.28 ethionamide
nusG 734407 p.Val52Ile missense_variant 0.16 rifampicin
nusG 734421 c.168A>G synonymous_variant 0.17 rifampicin
nusG 734424 c.171G>A synonymous_variant 0.19 rifampicin
nusG 734442 c.189G>A synonymous_variant 0.19 rifampicin
nusG 734451 c.198G>C synonymous_variant 0.21 rifampicin
nusG 734457 c.204C>G synonymous_variant 0.22 rifampicin
nusG 734472 c.219T>C synonymous_variant 0.24 rifampicin
nusG 734475 c.222T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
nusG 734532 c.279A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
nusG 734556 c.303C>T synonymous_variant 0.17 rifampicin
nusG 734559 c.306T>C synonymous_variant 0.17 rifampicin
nusG 734580 c.327T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 760091 c.285G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760101 c.295T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760112 c.306T>C synonymous_variant 0.2 rifampicin
rpoB 760118 c.312T>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760121 c.315T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760130 p.Asp108Glu missense_variant 0.22 rifampicin Uncertain significance
rpoB 760139 c.333A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 760142 c.336C>G synonymous_variant 0.24 rifampicin
rpoB 760181 c.375T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760184 c.378A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760196 c.390C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760223 c.417T>C synonymous_variant 0.3 rifampicin
rpoB 760235 c.429T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 760283 c.477G>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 760298 c.492G>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 760307 c.501T>C synonymous_variant 0.38 rifampicin
rpoB 760310 c.504G>C synonymous_variant 0.37 rifampicin
rpoB 760328 c.522G>C synonymous_variant 0.37 rifampicin
rpoB 760331 c.525G>C synonymous_variant 0.39 rifampicin
rpoB 760340 c.534G>T synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 760361 c.555T>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 760370 c.564C>G synonymous_variant 0.47 rifampicin
rpoB 760376 p.Asp190Glu missense_variant 0.44 rifampicin Uncertain significance
rpoB 760380 p.Thr192Leu missense_variant 0.41 rifampicin
rpoB 760406 c.600G>C synonymous_variant 0.42 rifampicin
rpoB 760412 c.606C>G synonymous_variant 0.4 rifampicin
rpoB 760424 c.618C>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 760430 c.624T>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 760475 c.669A>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 760481 c.675G>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 760484 c.678A>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 760522 p.Ser239Asn missense_variant 0.26 rifampicin Uncertain significance
rpoB 760532 c.726T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760533 p.Val243Thr missense_variant 0.22 rifampicin
rpoB 760541 c.735G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 760547 c.741G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 760563 p.Arg253Met missense_variant 0.17 rifampicin Uncertain significance
rpoB 760591 p.Val262Ala missense_variant 0.21 rifampicin
rpoB 760611 c.805T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760634 c.828T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760646 c.840C>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760655 c.849A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760886 c.1080A>G synonymous_variant 0.21 rifampicin
rpoB 760925 c.1119T>C synonymous_variant 0.36 rifampicin
rpoB 760934 c.1128C>T synonymous_variant 0.41 rifampicin
rpoB 760946 c.1140A>G synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 760982 c.1176G>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoB 760985 c.1179G>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoB 760991 c.1185G>C synonymous_variant 0.47 rifampicin
rpoB 761006 c.1200C>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 761015 c.1209G>C synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoB 761021 c.1215G>C synonymous_variant 0.53 rifampicin
rpoB 761027 c.1221A>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 761036 c.1230G>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoB 761037 c.1231T>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoB 761057 c.1251G>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 761102 c.1296A>G synonymous_variant 0.33 rifampicin
rpoB 761129 c.1323G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 761132 c.1326G>T synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 761133 c.1327T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 761150 c.1344A>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 761153 c.1347G>C synonymous_variant 0.3 rifampicin
rpoB 761165 c.1359G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 761180 c.1374A>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 761183 c.1377T>C synonymous_variant 0.33 rifampicin
rpoB 761189 c.1383T>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 761195 c.1389G>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 761207 c.1401C>T synonymous_variant 0.42 rifampicin
rpoB 761213 c.1407G>C synonymous_variant 0.39 rifampicin
rpoB 761219 c.1413G>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 761249 c.1443A>G synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 761255 c.1449T>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 761261 c.1455G>T synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 761306 c.1500C>G synonymous_variant 0.32 rifampicin
rpoB 761312 c.1506G>C synonymous_variant 0.33 rifampicin
rpoB 761327 c.1521A>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 761330 c.1524G>C synonymous_variant 0.29 rifampicin
rpoB 761354 c.1548C>T synonymous_variant 0.24 rifampicin
rpoB 761360 c.1554T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761362 p.Ser519Thr missense_variant 0.21 rifampicin
rpoB 761537 c.1731C>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 761570 c.1764T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 761573 c.1767C>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 761579 c.1773G>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 761588 c.1782C>T synonymous_variant 0.36 rifampicin
rpoB 761606 c.1800C>G synonymous_variant 0.34 rifampicin
rpoB 761612 c.1806G>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 761615 c.1809A>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 761636 c.1830G>T synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 761645 c.1839C>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 761648 c.1842T>C synonymous_variant 0.25 rifampicin
rpoB 761657 c.1851C>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 761675 c.1869G>C synonymous_variant 0.2 rifampicin
rpoB 761765 c.1959T>C synonymous_variant 0.18 rifampicin
rpoB 761772 p.His656Ala missense_variant 0.17 rifampicin
rpoB 761778 p.Asn658Asp missense_variant 0.18 rifampicin
rpoB 761791 p.Arg662His missense_variant 0.22 rifampicin
rpoB 761813 c.2007T>C synonymous_variant 0.28 rifampicin
rpoB 761815 p.Ala670Glu missense_variant 0.28 rifampicin
rpoB 761834 c.2028T>C synonymous_variant 0.3 rifampicin
rpoB 761848 p.Cys681Ser missense_variant 0.3 rifampicin
rpoB 761852 c.2046C>G synonymous_variant 0.31 rifampicin
rpoB 761858 c.2052G>C synonymous_variant 0.31 rifampicin
rpoB 761873 c.2067A>C synonymous_variant 0.34 rifampicin
rpoB 761885 c.2079T>C synonymous_variant 0.35 rifampicin
rpoB 761906 c.2100C>G synonymous_variant 0.3 rifampicin
rpoB 761909 c.2103T>C synonymous_variant 0.3 rifampicin
rpoB 761912 c.2106T>C synonymous_variant 0.31 rifampicin
rpoB 761915 p.Asp703Glu missense_variant 0.3 rifampicin
rpoB 761916 p.Asp704Asn missense_variant 0.3 rifampicin
rpoB 761948 c.2142G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 762008 c.2202C>T synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 762014 c.2208C>T synonymous_variant 0.3 rifampicin
rpoB 762017 c.2211A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 762053 c.2247T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 762062 c.2256T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 762083 c.2277T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 762086 c.2280G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 762101 c.2295C>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 762114 p.Ile770Val missense_variant 0.34 rifampicin Uncertain significance
rpoB 762131 c.2325C>G synonymous_variant 0.36 rifampicin
rpoB 762140 c.2334G>C synonymous_variant 0.34 rifampicin
rpoB 762143 c.2337T>C synonymous_variant 0.32 rifampicin
rpoB 762149 c.2343G>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 762167 c.2361T>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 762176 c.2370T>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 762185 c.2379G>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 762206 c.2400C>G synonymous_variant 0.38 rifampicin
rpoB 762233 c.2427G>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 762246 c.2440C>T synonymous_variant 0.39 rifampicin
rpoB 762254 c.2448T>G synonymous_variant 0.37 rifampicin
rpoB 762257 c.2451C>G synonymous_variant 0.36 rifampicin
rpoB 762266 c.2460T>C synonymous_variant 0.33 rifampicin
rpoB 762284 c.2478G>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 762293 c.2487T>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 762317 c.2511A>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 762329 c.2523G>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 762338 c.2532T>C synonymous_variant 0.34 rifampicin
rpoB 762347 c.2541T>C synonymous_variant 0.35 rifampicin
rpoB 762362 p.Glu852Asp missense_variant 0.34 rifampicin
rpoB 762369 c.2563T>C synonymous_variant 0.35 rifampicin
rpoC 762398 c.-972T>C upstream_gene_variant 0.39 rifampicin
rpoC 762401 c.-969G>C upstream_gene_variant 0.38 rifampicin
rpoB 762404 c.2598T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 762410 c.-960T>C upstream_gene_variant 0.42 rifampicin
rpoB 762416 c.2610A>G synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 762419 c.-951C>G upstream_gene_variant 0.43 rifampicin
rpoC 762434 c.-936T>C upstream_gene_variant 0.43 rifampicin
rpoB 762449 c.2643C>A synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 762467 c.-903C>T upstream_gene_variant 0.35 rifampicin
rpoB 762488 c.2682G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 762489 p.Val895Gln missense_variant 0.24 rifampicin
rpoC 762509 c.-861T>G upstream_gene_variant 0.23 rifampicin
rpoB 762510 p.Ala902Pro missense_variant 0.23 rifampicin Uncertain significance
rpoC 762521 c.-849C>T upstream_gene_variant 0.2 rifampicin
rpoC 762758 c.-612G>C upstream_gene_variant 0.26 rifampicin
rpoB 762782 c.2976T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 762785 p.Asp993Glu missense_variant 0.3 rifampicin Uncertain significance
rpoB 762788 c.2982G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 762789 p.Leu995Met missense_variant 0.3 rifampicin Uncertain significance
rpoC 762794 c.-576C>G upstream_gene_variant 0.31 rifampicin
rpoB 762799 p.Ala998Gly missense_variant 0.3 rifampicin Uncertain significance
rpoB 762810 p.Ala1002Ser missense_variant 0.3 rifampicin
rpoB 762813 p.Met1003Val missense_variant 0.3 rifampicin
rpoB 762818 c.3012C>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 762827 c.3021G>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 762857 c.3051C>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 762860 c.3054G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 762863 c.3057T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 762929 c.3123G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>C synonymous_variant 1.0 rifampicin Not assoc w R
rpoB 763070 c.3264T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 763085 c.3279C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 763115 c.3309T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 763136 c.3330C>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 763148 c.-222G>C upstream_gene_variant 0.21 rifampicin
rpoC 763158 c.-212C>T upstream_gene_variant 0.23 rifampicin
rpoB 763166 c.3360A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 763190 c.-180C>T upstream_gene_variant 0.22 rifampicin
rpoC 763202 c.-168A>G upstream_gene_variant 0.19 rifampicin
rpoC 763205 c.-165G>C upstream_gene_variant 0.19 rifampicin
rpoC 763206 c.-164_-162delAGTinsTCG upstream_gene_variant 0.21 rifampicin
rpoB 763214 c.3408T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 763226 c.-144A>G upstream_gene_variant 0.21 rifampicin
rpoB 763227 c.3421C>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 763238 c.3432T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 763253 c.-117G>C upstream_gene_variant 0.19 rifampicin
rpoC 763256 c.-114G>A upstream_gene_variant 0.19 rifampicin
rpoB 763268 c.3462C>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 763402 c.33C>G synonymous_variant 0.15 rifampicin
rpoC 763411 c.42T>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 763414 c.45T>C synonymous_variant 0.2 rifampicin
rpoC 763441 c.72C>T synonymous_variant 0.21 rifampicin
rpoC 763444 c.75T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 763456 c.87A>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 763486 c.117T>G synonymous_variant 0.31 rifampicin
rpoC 763528 c.159G>A synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 763573 c.204G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 763594 c.225C>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 763603 c.234C>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 763636 c.267T>C synonymous_variant 0.22 rifampicin
rpoC 763660 c.291T>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 763675 c.306C>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 763696 c.327T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 763702 c.333C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 763717 c.348T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 763723 c.354G>C synonymous_variant 0.18 rifampicin
rpoC 763732 c.363C>G synonymous_variant 0.19 rifampicin
rpoC 764059 c.690G>T synonymous_variant 0.2 rifampicin
rpoC 764083 c.714A>G synonymous_variant 0.27 rifampicin
rpoC 764098 c.729A>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 764101 c.732C>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 764112 p.Tyr248Phe missense_variant 0.32 rifampicin
rpoC 764116 c.747C>T synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 764131 c.762T>C synonymous_variant 0.31 rifampicin
rpoC 764140 c.771C>T synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 764188 c.819A>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 764195 p.Ser276Ile missense_variant 0.34 rifampicin
rpoC 764203 c.834G>C synonymous_variant 0.29 rifampicin
rpoC 764206 c.837T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764215 c.846A>G synonymous_variant 0.31 rifampicin
rpoC 764236 c.867G>A synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764248 c.879C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 764257 c.888G>C synonymous_variant 0.27 rifampicin
rpoC 764266 c.897T>C synonymous_variant 0.24 rifampicin
rpoC 764269 c.900G>C synonymous_variant 0.25 rifampicin
rpoC 764272 c.903G>C synonymous_variant 0.25 rifampicin
rpoC 764278 c.909A>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764338 c.969G>A synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764353 c.984G>C synonymous_variant 0.28 rifampicin
rpoC 764365 c.996C>T synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 764380 c.1011G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764381 c.1012_1013delTCinsAG synonymous_variant 0.28 rifampicin
rpoC 764387 c.1018_1020delTTGinsCTC synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764405 c.1036A>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 764419 c.1050C>G synonymous_variant 0.29 rifampicin
rpoC 764428 c.1059G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764431 c.1062G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764434 c.1065A>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 764446 c.1077T>C synonymous_variant 0.21 rifampicin
rpoC 764449 c.1080G>C synonymous_variant 0.21 rifampicin
rpoC 764452 c.1083T>C synonymous_variant 0.21 rifampicin
rpoC 764458 c.1089G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764461 c.1092A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 764489 c.1120C>T synonymous_variant 0.24 rifampicin
rpoC 764497 c.1128A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764510 c.1141C>T synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 764521 c.1152T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764527 c.1158C>T synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764536 c.1167G>C synonymous_variant 0.3 rifampicin
rpoC 764539 c.1170C>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 764554 c.1185C>T synonymous_variant 0.38 rifampicin
rpoC 764560 c.1191T>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 764566 c.1197C>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 764575 c.1206T>G synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 764581 c.1212T>C synonymous_variant 0.39 rifampicin
rpoC 764593 c.1224C>T synonymous_variant 0.4 rifampicin
rpoC 764611 c.1242G>T synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>C synonymous_variant 0.39 rifampicin
rpoC 764651 c.1282_1284delTCGinsAGC synonymous_variant 0.38 rifampicin
rpoC 764752 c.1383G>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 764764 c.1395T>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 764809 c.1440C>T synonymous_variant 0.47 rifampicin Not assoc w R
rpoC 764815 c.1446A>G synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 764819 p.Trp484Gly missense_variant 0.34 rifampicin Uncertain significance
rpoC 764827 c.1458G>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 764858 c.1489T>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 764872 c.1503A>G synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 764888 c.1519T>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 764911 c.1542A>G synonymous_variant 0.47 rifampicin
rpoC 764932 c.1563C>A synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 764935 c.1566T>C synonymous_variant 0.47 rifampicin
rpoC 764948 c.1579T>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 764968 c.1599T>C synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoC 764995 c.1626C>G synonymous_variant 0.54 rifampicin Not assoc w R
rpoC 765019 c.1650A>G synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoC 765034 c.1665T>C synonymous_variant 0.5 rifampicin
rpoC 765040 c.1671T>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 765041 c.1672T>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 765047 c.1678T>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 765053 c.1684_1685delTCinsAG synonymous_variant 0.46 rifampicin
rpoC 765073 c.1704G>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 765076 c.1707A>G synonymous_variant 0.4 rifampicin
rpoC 765079 c.1710T>G synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 765082 c.1713G>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 765089 c.1720T>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 765103 c.1734G>T synonymous_variant 0.36 rifampicin
rpoC 765319 c.1950A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 765326 p.His653Ala missense_variant 0.21 rifampicin Uncertain significance
rpoC 765329 p.Ser654Gly missense_variant 0.22 rifampicin
rpoC 765346 c.1977C>G synonymous_variant 0.23 rifampicin
rpoC 765349 c.1980T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 765352 c.1983G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 765383 p.Met672Leu missense_variant 0.3 rifampicin Uncertain significance
rpoC 765404 p.Leu679Val missense_variant 0.33 rifampicin
rpoC 765409 c.2040T>C synonymous_variant 0.31 rifampicin
rpoC 765421 c.2052C>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 765478 c.2109T>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 765499 c.2130C>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 765529 c.2160C>T synonymous_variant 0.46 rifampicin
rpoC 765541 c.2172C>G synonymous_variant 0.46 rifampicin
rpoC 765553 c.2184C>T synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 765556 c.2187G>C synonymous_variant 0.47 rifampicin
rpoC 765559 c.2190G>C synonymous_variant 0.48 rifampicin
rpoC 765580 c.2211G>C synonymous_variant 0.51 rifampicin
rpoC 765613 p.His748Gln missense_variant 0.46 rifampicin
rpoC 765625 c.2256C>G synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 765631 p.Asp754Glu missense_variant 0.44 rifampicin
rpoC 765700 c.2331T>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 765734 c.2365T>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 765739 c.2370G>T synonymous_variant 0.42 rifampicin
rpoC 765751 c.2382C>G synonymous_variant 0.39 rifampicin
rpoC 765753 p.Asp795Ala missense_variant 0.39 rifampicin Uncertain significance
rpoC 765772 c.2403C>G synonymous_variant 0.41 rifampicin
rpoC 765784 c.2415C>G synonymous_variant 0.4 rifampicin
rpoC 765787 c.2418C>T synonymous_variant 0.41 rifampicin
rpoC 765793 c.2424C>G synonymous_variant 0.4 rifampicin
rpoC 765796 c.2427C>T synonymous_variant 0.4 rifampicin
rpoC 765811 c.2442T>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 765814 c.2445A>G synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 765826 c.2457T>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 765835 c.2466C>T synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 765850 c.2481G>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 765883 c.2514C>G synonymous_variant 0.38 rifampicin
rpoC 765886 c.2517C>G synonymous_variant 0.38 rifampicin
rpoC 765892 c.2523T>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 765937 c.2568T>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 765967 c.2598C>T synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 765982 c.2613C>G synonymous_variant 0.25 rifampicin
rpoC 765994 c.2625A>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 766010 c.2641_2642delTCinsAG synonymous_variant 0.16 rifampicin
rpoC 766021 c.2652G>C synonymous_variant 0.2 rifampicin
rpoC 766027 c.2658G>C synonymous_variant 0.19 rifampicin
rpoC 766043 p.Gln892Glu missense_variant 0.16 rifampicin
rpoC 766129 c.2760C>G synonymous_variant 0.15 rifampicin
rpoC 766135 c.2766G>A synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 766303 c.2934C>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 766312 c.2943T>G synonymous_variant 0.2 rifampicin
rpoC 766327 c.2958C>A synonymous_variant 0.17 rifampicin
rpoC 766345 c.2976T>C synonymous_variant 0.19 rifampicin
rpoC 766348 c.2979A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 766357 c.2988C>T synonymous_variant 0.19 rifampicin
rpoC 766363 c.2994G>C synonymous_variant 0.19 rifampicin
rpoC 766366 c.2997C>G synonymous_variant 0.19 rifampicin
rpoC 766381 c.3012C>T synonymous_variant 0.25 rifampicin
rpoC 766384 c.3015A>G synonymous_variant 0.24 rifampicin
rpoC 766390 c.3021C>T synonymous_variant 0.26 rifampicin
rpoC 766393 c.3024C>G synonymous_variant 0.24 rifampicin
rpoC 766408 c.3039C>G synonymous_variant 0.29 rifampicin
rpoC 766411 c.3042C>G synonymous_variant 0.29 rifampicin
rpoC 766426 c.3057C>T synonymous_variant 0.35 rifampicin
rpoC 766447 c.3078T>C synonymous_variant 0.35 rifampicin
rpoC 766462 c.3093G>C synonymous_variant 0.28 rifampicin
rpoC 766483 c.3114G>C synonymous_variant 0.29 rifampicin
rpoC 766484 p.Val1039Ile missense_variant 0.29 rifampicin Uncertain significance
rpoC 766492 c.3123T>C synonymous_variant 0.31 rifampicin
rpoC 766522 c.3153C>G synonymous_variant 0.33 rifampicin
rpoC 766528 c.3159T>C synonymous_variant 0.34 rifampicin
rpoC 766531 c.3162G>C synonymous_variant 0.34 rifampicin
rpoC 766540 p.Asp1057Glu missense_variant 0.33 rifampicin
rpoC 766549 c.3180G>C synonymous_variant 0.31 rifampicin
rpoC 766573 c.3204T>C synonymous_variant 0.26 rifampicin
rpoC 766582 c.3213C>G synonymous_variant 0.26 rifampicin
rpoC 766583 p.Gly1072Ser missense_variant 0.25 rifampicin
rpoC 766591 c.3222A>G synonymous_variant 0.25 rifampicin
rpoC 766594 c.3225G>C synonymous_variant 0.26 rifampicin
rpoC 766597 c.3228C>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 766607 p.Ile1080Leu missense_variant 0.32 rifampicin
rpoC 766630 c.3261G>C synonymous_variant 0.39 rifampicin
rpoC 766657 c.3288A>G synonymous_variant 0.38 rifampicin
rpoC 766672 c.3303T>C synonymous_variant 0.34 rifampicin
rpoC 766673 p.Gly1102Asn missense_variant 0.33 rifampicin
rpoC 766738 c.3369G>C synonymous_variant 0.34 rifampicin
rpoC 766747 c.3378C>T synonymous_variant 0.32 rifampicin
rpoC 766765 c.3396A>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 766774 c.3405T>C synonymous_variant 0.24 rifampicin
rpoC 766801 c.3432C>G synonymous_variant 0.2 rifampicin
rpoC 766804 c.3435A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 766861 c.3492G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 766864 c.3495G>C synonymous_variant 0.14 rifampicin
mmpL5 775639 p.Ile948Val missense_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
mmpL5 776100 p.Thr794Ile missense_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
mmpL5 776182 p.Asp767Asn missense_variant 0.98 bedaquiline Not assoc w R
clofazimine Not assoc w R
mmpS5 779615 c.-710C>G upstream_gene_variant 0.98 bedaquiline
clofazimine
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781631 c.72G>C synonymous_variant 0.15 streptomycin
rpsL 781649 c.90T>C synonymous_variant 0.22 streptomycin
rpsL 781655 c.96T>C synonymous_variant 0.23 streptomycin
rpsL 781682 c.123T>C synonymous_variant 0.35 streptomycin
rpsL 781700 c.141G>C synonymous_variant 0.36 streptomycin
rpsL 781703 c.144G>T synonymous_variant 0.36 streptomycin
rpsL 781715 c.156T>C synonymous_variant 0.36 streptomycin
rpsL 781728 c.169T>C synonymous_variant 0.38 streptomycin
rpsL 781736 c.177T>C synonymous_variant 0.39 streptomycin
rpsL 781742 c.183C>T synonymous_variant 0.39 streptomycin
rpsL 781748 c.189C>G synonymous_variant 0.39 streptomycin
rpsL 781754 c.195G>T synonymous_variant 0.39 streptomycin
rpsL 781760 c.201T>C synonymous_variant 0.41 streptomycin
rpsL 781802 c.243G>C synonymous_variant 0.38 streptomycin
rpsL 781808 c.249C>T synonymous_variant 0.38 streptomycin
rpsL 781811 c.252C>T synonymous_variant 0.38 streptomycin
rpsL 781832 c.273T>G synonymous_variant 0.36 streptomycin
rpsL 781838 c.279G>C synonymous_variant 0.38 streptomycin
rpsL 781841 c.282C>G synonymous_variant 0.4 streptomycin
rpsL 781865 c.306G>C synonymous_variant 0.39 streptomycin
rpsL 781868 c.309T>C synonymous_variant 0.39 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.37 streptomycin
rpsL 781877 c.318T>C synonymous_variant 0.37 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.38 streptomycin
rpsL 781898 c.339A>T synonymous_variant 0.4 streptomycin
rpsL 781916 c.357T>C synonymous_variant 0.39 streptomycin
rpsL 781929 p.Gly124Ser missense_variant 0.39 streptomycin Uncertain significance
rplC 800516 c.-293G>T upstream_gene_variant 0.28 linezolid
rplC 800537 c.-272C>T upstream_gene_variant 0.34 linezolid
rplC 800540 c.-269T>C upstream_gene_variant 0.35 linezolid
rplC 800546 c.-263T>G upstream_gene_variant 0.41 linezolid
rplC 800567 c.-242A>G upstream_gene_variant 0.44 linezolid
rplC 800582 c.-227C>G upstream_gene_variant 0.43 linezolid
rplC 800612 c.-197A>G upstream_gene_variant 0.46 linezolid
rplC 800618 c.-191T>C upstream_gene_variant 0.46 linezolid
rplC 800627 c.-182C>T upstream_gene_variant 0.4 linezolid
rplC 800648 c.-161A>T upstream_gene_variant 0.45 linezolid
rplC 800654 c.-155T>C upstream_gene_variant 0.42 linezolid
rplC 800693 c.-116A>G upstream_gene_variant 0.33 linezolid
rplC 800703 c.-106T>C upstream_gene_variant 0.34 linezolid
rplC 800714 c.-95C>T upstream_gene_variant 0.36 linezolid
rplC 800715 c.-94A>C upstream_gene_variant 0.36 linezolid
rplC 800720 c.-89T>C upstream_gene_variant 0.36 linezolid
rplC 800723 c.-86C>G upstream_gene_variant 0.38 linezolid
rplC 800747 c.-62C>G upstream_gene_variant 0.31 linezolid
rplC 800771 c.-38C>T upstream_gene_variant 0.32 linezolid
rplC 800794 c.-15A>G upstream_gene_variant 0.26 linezolid
rplC 800796 c.-13A>G upstream_gene_variant 0.26 linezolid
rplC 800798 c.-10_-9delGG upstream_gene_variant 0.27 linezolid
rplC 800814 c.6A>G synonymous_variant 0.24 linezolid
rplC 800817 c.9A>T synonymous_variant 0.25 linezolid
rplC 800844 c.36T>C synonymous_variant 0.19 linezolid
rplC 801321 c.513C>T synonymous_variant 0.22 linezolid Not assoc w R - Interim
rplC 801324 c.516T>C synonymous_variant 0.23 linezolid
rplC 801339 c.531T>C synonymous_variant 0.22 linezolid
rplC 801341 p.Leu178Gln missense_variant 0.19 linezolid
rplC 801348 c.540T>G synonymous_variant 0.19 linezolid
rplC 801357 c.549T>C synonymous_variant 0.19 linezolid
rplC 801367 p.Ala187Thr missense_variant 0.18 linezolid
rplC 801402 c.594T>C synonymous_variant 0.2 linezolid
rplC 801405 c.597T>C synonymous_variant 0.2 linezolid
rplC 801423 c.615G>C synonymous_variant 0.23 linezolid
rplC 801426 c.618C>G synonymous_variant 0.23 linezolid
rplC 801427 p.Met207Val missense_variant 0.23 linezolid
rplC 801438 c.630T>C synonymous_variant 0.18 linezolid
rplC 801442 p.Ile212Val missense_variant 0.18 linezolid
Rv1129c 1254562 c.-28T>C upstream_gene_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
isoniazid Not assoc w R
rifampicin Not assoc w R
fbiC 1303695 c.765T>C synonymous_variant 0.18 pretomanid
delamanid
clofazimine
fbiC 1303704 c.774T>C synonymous_variant 0.16 pretomanid
delamanid
clofazimine
fbiC 1304907 c.1977C>G synonymous_variant 0.21 pretomanid
delamanid
clofazimine
fbiC 1304910 c.1980G>C synonymous_variant 0.21 pretomanid
delamanid
clofazimine
fbiC 1304916 c.1986T>C synonymous_variant 0.22 pretomanid
delamanid
clofazimine
fbiC 1304928 c.1998T>C synonymous_variant 0.19 pretomanid
delamanid
clofazimine
fbiC 1304937 c.2007G>C synonymous_variant 0.18 pretomanid
delamanid
clofazimine
sigE 1364802 c.390C>A synonymous_variant 0.13 pyrazinamide
sigE 1364805 c.393C>G synonymous_variant 0.14 pyrazinamide
sigE 1364814 c.402C>G synonymous_variant 0.18 pyrazinamide
sigE 1364820 c.408A>G synonymous_variant 0.17 pyrazinamide
Rv1258c 1406760 c.580_581insC frameshift_variant 1.0 streptomycin Uncertain significance
pyrazinamide Uncertain significance
isoniazid Uncertain significance
atpE 1460816 c.-229T>C upstream_gene_variant 0.19 bedaquiline
atpE 1460831 c.-214T>C upstream_gene_variant 0.22 bedaquiline
atpE 1460840 c.-205A>G upstream_gene_variant 0.24 bedaquiline
atpE 1460852 c.-193C>G upstream_gene_variant 0.24 bedaquiline
atpE 1460855 c.-190T>C upstream_gene_variant 0.24 bedaquiline
atpE 1460858 c.-187C>G upstream_gene_variant 0.23 bedaquiline
atpE 1460861 c.-184C>G upstream_gene_variant 0.24 bedaquiline
atpE 1460882 c.-163T>C upstream_gene_variant 0.27 bedaquiline
atpE 1460894 c.-151A>G upstream_gene_variant 0.21 bedaquiline
atpE 1460897 c.-148A>C upstream_gene_variant 0.2 bedaquiline
atpE 1460900 c.-145T>C upstream_gene_variant 0.2 bedaquiline
atpE 1460915 c.-130C>G upstream_gene_variant 0.19 bedaquiline
atpE 1460918 c.-127A>G upstream_gene_variant 0.19 bedaquiline
atpE 1461089 c.45G>C synonymous_variant 0.23 bedaquiline
atpE 1461097 p.Ala18Gly missense_variant 0.23 bedaquiline
atpE 1461101 c.57T>C synonymous_variant 0.24 bedaquiline
atpE 1461107 c.63C>G synonymous_variant 0.28 bedaquiline
atpE 1461113 c.69C>T synonymous_variant 0.27 bedaquiline
atpE 1461132 p.Val30Ile missense_variant 0.33 bedaquiline
atpE 1461149 c.105T>G synonymous_variant 0.35 bedaquiline
atpE 1461150 p.Ile36Val missense_variant 0.35 bedaquiline
atpE 1461158 c.114T>G synonymous_variant 0.36 bedaquiline
atpE 1461159 p.Val39Ile missense_variant 0.36 bedaquiline Uncertain significance
atpE 1461170 c.126A>G synonymous_variant 0.35 bedaquiline
atpE 1461185 c.141G>T synonymous_variant 0.32 bedaquiline
atpE 1461197 c.153A>G synonymous_variant 0.32 bedaquiline
atpE 1461219 c.175T>C synonymous_variant 0.31 bedaquiline
atpE 1461233 c.189A>C synonymous_variant 0.22 bedaquiline
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 kanamycin
capreomycin
streptomycin
amikacin
rrs 1471923 n.78T>C non_coding_transcript_exon_variant 0.38 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1471925 n.80T>C non_coding_transcript_exon_variant 0.38 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1471932 n.87A>G non_coding_transcript_exon_variant 0.37 kanamycin
capreomycin
streptomycin
amikacin
rrs 1471934 n.89A>G non_coding_transcript_exon_variant 0.37 kanamycin
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1471969 n.124T>C non_coding_transcript_exon_variant 0.37 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1471970 n.125G>A non_coding_transcript_exon_variant 0.37 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472028 n.183A>T non_coding_transcript_exon_variant 0.28 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472029 n.184C>T non_coding_transcript_exon_variant 0.28 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472030 n.185G>T non_coding_transcript_exon_variant 0.28 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472031 n.186G>A non_coding_transcript_exon_variant 0.27 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472033 n.188A>G non_coding_transcript_exon_variant 0.27 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472034 n.189T>C non_coding_transcript_exon_variant 0.27 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472044 n.199G>T non_coding_transcript_exon_variant 0.31 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472045 n.200T>A non_coding_transcript_exon_variant 0.31 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472053 n.211_212delGC non_coding_transcript_exon_variant 0.34 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472061 n.216A>T non_coding_transcript_exon_variant 0.35 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472075 n.230A>G non_coding_transcript_exon_variant 0.47 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.47 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472300 n.455C>T non_coding_transcript_exon_variant 0.23 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472969 n.1124A>G non_coding_transcript_exon_variant 0.45 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472970 n.1125C>G non_coding_transcript_exon_variant 0.45 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472977 n.1132G>C non_coding_transcript_exon_variant 0.42 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472978 n.1133T>C non_coding_transcript_exon_variant 0.42 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473105 n.1260G>A non_coding_transcript_exon_variant 0.4 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1473123 n.1278delAinsTT non_coding_transcript_exon_variant 0.42 kanamycin
capreomycin
streptomycin
amikacin
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.46 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.42 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrl 1474093 n.436G>T non_coding_transcript_exon_variant 0.37 capreomycin
linezolid
rrl 1474099 n.442G>A non_coding_transcript_exon_variant 0.36 capreomycin
linezolid
rrl 1474103 n.446A>T non_coding_transcript_exon_variant 0.38 capreomycin
linezolid
rrl 1474140 n.483C>T non_coding_transcript_exon_variant 0.43 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474639 n.982G>A non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475761 n.2104_2106delCGCinsGT non_coding_transcript_exon_variant 0.29 capreomycin
linezolid
rrl 1475765 n.2111delG non_coding_transcript_exon_variant 0.31 capreomycin
linezolid
rpsA 1833532 c.-10A>C upstream_gene_variant 0.15 pyrazinamide
rpsA 1833554 p.Thr5Ala missense_variant 0.26 pyrazinamide Uncertain significance
rpsA 1833568 c.27G>C synonymous_variant 0.29 pyrazinamide Not assoc w R - Interim
rpsA 1833589 c.48A>T synonymous_variant 0.36 pyrazinamide
rpsA 1833595 c.54T>C synonymous_variant 0.37 pyrazinamide
rpsA 1833661 c.120A>G synonymous_variant 0.39 pyrazinamide
rpsA 1833667 c.126C>G synonymous_variant 0.43 pyrazinamide
rpsA 1833721 c.180A>G synonymous_variant 0.37 pyrazinamide
rpsA 1833724 c.183C>G synonymous_variant 0.34 pyrazinamide
rpsA 1833727 c.186G>C synonymous_variant 0.34 pyrazinamide
rpsA 1833742 c.201A>G synonymous_variant 0.35 pyrazinamide
rpsA 1833745 c.204G>C synonymous_variant 0.34 pyrazinamide
rpsA 1833748 c.207C>G synonymous_variant 0.34 pyrazinamide
rpsA 1833787 c.246C>G synonymous_variant 0.29 pyrazinamide
rpsA 1833790 c.249T>C synonymous_variant 0.31 pyrazinamide
rpsA 1833802 c.261A>G synonymous_variant 0.31 pyrazinamide
rpsA 1833811 c.270G>T synonymous_variant 0.29 pyrazinamide
rpsA 1833838 c.297G>C synonymous_variant 0.26 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.26 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.26 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.26 pyrazinamide
rpsA 1833874 c.333T>C synonymous_variant 0.24 pyrazinamide
rpsA 1833886 c.345C>G synonymous_variant 0.24 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.34 pyrazinamide
rpsA 1833940 c.399C>G synonymous_variant 0.38 pyrazinamide
rpsA 1833971 c.430C>T synonymous_variant 0.33 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.32 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.3 pyrazinamide
rpsA 1834021 c.480C>T synonymous_variant 0.31 pyrazinamide
rpsA 1834030 c.489C>G synonymous_variant 0.3 pyrazinamide
rpsA 1834081 c.540C>T synonymous_variant 0.15 pyrazinamide
rpsA 1834177 c.636A>C synonymous_variant 0.98 pyrazinamide Not assoc w R - Interim
rpsA 1834249 c.708T>C synonymous_variant 0.16 pyrazinamide
rpsA 1834261 c.720A>G synonymous_variant 0.15 pyrazinamide Not assoc w R - Interim
rpsA 1834262 p.Ser241Thr missense_variant 0.15 pyrazinamide
rpsA 1834303 c.762T>C synonymous_variant 0.22 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.22 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 0.21 pyrazinamide Not assoc w R - Interim
rpsA 1834366 c.825A>G synonymous_variant 0.23 pyrazinamide Not assoc w R - Interim
rpsA 1834396 c.855G>C synonymous_variant 0.21 pyrazinamide
rpsA 1834411 c.870T>C synonymous_variant 0.21 pyrazinamide
rpsA 1834417 c.876G>C synonymous_variant 0.21 pyrazinamide
rpsA 1834423 c.882G>C synonymous_variant 0.21 pyrazinamide
rpsA 1834435 c.894G>C synonymous_variant 0.2 pyrazinamide
rpsA 1834451 c.910T>C synonymous_variant 0.17 pyrazinamide
rpsA 1834465 c.924T>C synonymous_variant 0.15 pyrazinamide
rpsA 1834639 c.1098T>C synonymous_variant 0.15 pyrazinamide
rpsA 1834654 p.Glu371Asp missense_variant 0.18 pyrazinamide
rpsA 1834690 c.1149T>C synonymous_variant 0.33 pyrazinamide
rpsA 1834732 c.1191T>C synonymous_variant 0.38 pyrazinamide
rpsA 1834733 p.Ala398Ser missense_variant 0.39 pyrazinamide
rpsA 1834738 c.1197A>G synonymous_variant 0.39 pyrazinamide
rpsA 1834753 c.1212T>C synonymous_variant 0.36 pyrazinamide
rpsA 1834765 p.Glu408Asp missense_variant 0.36 pyrazinamide
rpsA 1834775 p.Ala412Thr missense_variant 0.36 pyrazinamide
rpsA 1834780 c.1239A>G synonymous_variant 0.33 pyrazinamide
rpsA 1834786 c.1245A>G synonymous_variant 0.29 pyrazinamide
rpsA 1834789 c.1248T>C synonymous_variant 0.23 pyrazinamide
rpsA 1834792 c.1251G>C synonymous_variant 0.23 pyrazinamide
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
ndh 2101830 p.Ile405Val missense_variant 0.2 isoniazid
delamanid
ethionamide
ndh 2101837 p.Ala402Val missense_variant 0.2 isoniazid Uncertain significance
delamanid
ethionamide Uncertain significance
ndh 2101872 p.Ile391Phe missense_variant 0.16 isoniazid
delamanid
ethionamide
ndh 2101873 p.Phe390Leu missense_variant 0.16 isoniazid
delamanid
ethionamide
ndh 2101885 c.1158G>A synonymous_variant 0.19 isoniazid
delamanid
ethionamide
ndh 2101888 c.1155T>C synonymous_variant 0.21 isoniazid
delamanid
ethionamide
ndh 2101894 c.1149T>G synonymous_variant 0.23 isoniazid
delamanid
ethionamide
ndh 2101912 c.1131G>C synonymous_variant 0.25 isoniazid
delamanid
ethionamide
ndh 2101920 c.1123A>C synonymous_variant 0.24 isoniazid
delamanid
ethionamide
ndh 2101924 c.1119T>G synonymous_variant 0.21 isoniazid
delamanid
ethionamide
ndh 2101939 c.1104A>G synonymous_variant 0.19 isoniazid
delamanid
ethionamide
ndh 2101960 c.1083A>G synonymous_variant 0.16 isoniazid
delamanid
ethionamide
ndh 2101963 c.1080G>A synonymous_variant 0.16 isoniazid Not assoc w R - Interim
delamanid Not assoc w R - Interim
ethionamide Not assoc w R - Interim
ndh 2101966 c.1077T>G synonymous_variant 0.16 isoniazid
delamanid
ethionamide
ndh 2101972 c.1071G>C synonymous_variant 0.15 isoniazid
delamanid
ethionamide
ndh 2101988 p.Ala352Asp missense_variant 0.15 isoniazid
delamanid
ethionamide
ndh 2101990 c.1053G>C synonymous_variant 0.15 isoniazid
delamanid
ethionamide
ndh 2101993 c.1050A>G synonymous_variant 0.17 isoniazid
delamanid
ethionamide
ndh 2102014 c.1029C>G synonymous_variant 0.15 isoniazid
delamanid
ethionamide
katG 2154724 p.Arg463Leu missense_variant 0.95 isoniazid Not assoc w R
katG 2155691 c.421T>C synonymous_variant 0.18 isoniazid
katG 2155695 c.417C>G synonymous_variant 0.18 isoniazid
katG 2155704 c.408C>G synonymous_variant 0.18 isoniazid
katG 2155716 c.396T>G synonymous_variant 0.2 isoniazid
katG 2155722 c.390G>C synonymous_variant 0.17 isoniazid
katG 2155728 c.384G>C synonymous_variant 0.15 isoniazid
katG 2155742 p.Gly124Arg missense_variant 0.16 isoniazid
katG 2155743 c.369G>C synonymous_variant 0.15 isoniazid
PPE35 2167926 p.Leu896Ser missense_variant 1.0 pyrazinamide Not assoc w R
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
kasA 2517950 c.-165C>G upstream_gene_variant 0.29 isoniazid
kasA 2517989 c.-126T>C upstream_gene_variant 0.21 isoniazid
kasA 2517993 c.-122G>T upstream_gene_variant 0.19 isoniazid
kasA 2518732 c.618C>G synonymous_variant 0.15 isoniazid
Rv2477c 2783563 c.480A>G synonymous_variant 0.23 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783572 c.471A>G synonymous_variant 0.22 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783586 p.Ala153Pro missense_variant 0.23 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783593 c.450T>C synonymous_variant 0.25 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783605 c.438T>C synonymous_variant 0.26 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783620 c.423C>G synonymous_variant 0.31 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783628 p.Ala139Ser missense_variant 0.33 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783656 c.387G>C synonymous_variant 0.33 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783665 c.378A>G synonymous_variant 0.34 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783674 c.369T>C synonymous_variant 0.31 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783683 c.360A>G synonymous_variant 0.33 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783700 p.Thr115Ser missense_variant 0.36 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783718 c.325T>C synonymous_variant 0.35 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783719 c.324A>G synonymous_variant 0.35 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783751 p.Ile98Val missense_variant 0.29 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783758 p.Asp95Glu missense_variant 0.31 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783761 c.282G>C synonymous_variant 0.29 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783766 p.Met93Leu missense_variant 0.27 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783776 c.267G>C synonymous_variant 0.28 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783779 c.264T>C synonymous_variant 0.25 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783797 p.Asp82Glu missense_variant 0.28 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783815 c.228A>G synonymous_variant 0.29 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783821 p.Gln74Leu missense_variant 0.26 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783833 c.210G>C synonymous_variant 0.32 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783839 c.204C>G synonymous_variant 0.32 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783843 p.Gly67Asp missense_variant 0.31 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783846 p.Thr66Asn missense_variant 0.31 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783860 c.183T>C synonymous_variant 0.27 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783863 c.180C>T synonymous_variant 0.28 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783883 c.160T>C synonymous_variant 0.28 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783884 c.159T>C synonymous_variant 0.28 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783887 c.156C>G synonymous_variant 0.33 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783914 c.129T>C synonymous_variant 0.31 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783920 c.123G>C synonymous_variant 0.29 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783929 c.114C>G synonymous_variant 0.29 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783932 c.111C>T synonymous_variant 0.3 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783938 c.105T>C synonymous_variant 0.29 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783953 c.90G>A synonymous_variant 0.27 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783962 c.81T>C synonymous_variant 0.26 kanamycin Not assoc w R - Interim
levofloxacin
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783971 c.72G>C synonymous_variant 0.24 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783980 c.63C>G synonymous_variant 0.2 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783992 c.51T>C synonymous_variant 0.16 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin
Rv2752c 3066002 p.Met64Leu missense_variant 0.17 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066009 c.183G>C synonymous_variant 0.17 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066012 c.180C>A synonymous_variant 0.17 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066018 c.174T>C synonymous_variant 0.16 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066024 c.168T>G synonymous_variant 0.15 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066476 c.-285C>G upstream_gene_variant 0.16 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066482 c.-291G>T upstream_gene_variant 0.16 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066483 c.-292T>C upstream_gene_variant 0.16 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066501 c.-310G>C upstream_gene_variant 0.25 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066522 c.-331C>G upstream_gene_variant 0.33 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066531 c.-340C>G upstream_gene_variant 0.36 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066549 c.-358T>C upstream_gene_variant 0.36 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066561 c.-370A>C upstream_gene_variant 0.3 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066567 c.-376C>G upstream_gene_variant 0.27 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066573 c.-382G>C upstream_gene_variant 0.27 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066579 c.-388A>G upstream_gene_variant 0.27 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066582 c.-392_-391delCCinsGG upstream_gene_variant 0.28 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066603 c.-412A>G upstream_gene_variant 0.31 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066617 c.-426G>A upstream_gene_variant 0.29 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066618 c.-427A>G upstream_gene_variant 0.29 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066633 c.-442T>C upstream_gene_variant 0.26 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066638 c.-447T>G upstream_gene_variant 0.23 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066642 c.-453_-451delTTGinsCTC upstream_gene_variant 0.24 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066654 c.-463G>C upstream_gene_variant 0.22 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066657 c.-466C>G upstream_gene_variant 0.21 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066707 c.-516A>G upstream_gene_variant 0.15 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066713 c.-522C>T upstream_gene_variant 0.15 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066714 c.-523G>A upstream_gene_variant 0.16 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066734 c.-543G>A upstream_gene_variant 0.19 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066744 c.-553C>G upstream_gene_variant 0.15 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066747 c.-558_-556delCAAinsATC upstream_gene_variant 0.16 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066756 c.-567_-565delCGGinsAGC upstream_gene_variant 0.16 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066762 c.-571G>C upstream_gene_variant 0.15 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066771 c.-580C>G upstream_gene_variant 0.15 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066774 c.-583T>C upstream_gene_variant 0.16 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066780 c.-589C>G upstream_gene_variant 0.15 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066810 c.-619G>A upstream_gene_variant 0.16 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066819 c.-628T>C upstream_gene_variant 0.16 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066822 c.-631T>C upstream_gene_variant 0.17 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066839 c.-648A>G upstream_gene_variant 0.15 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
thyX 3067316 c.630A>G synonymous_variant 0.15 para-aminosalicylic_acid
thyX 3067325 c.621A>G synonymous_variant 0.15 para-aminosalicylic_acid
thyX 3067515 p.Ser144Thr missense_variant 0.19 para-aminosalicylic_acid
thyX 3067530 p.Ala139Ser missense_variant 0.23 para-aminosalicylic_acid
thyX 3067545 p.Glu134Ala missense_variant 0.25 para-aminosalicylic_acid
thyX 3067549 p.Thr133Ala missense_variant 0.23 para-aminosalicylic_acid
thyX 3067556 p.His130Gln missense_variant 0.23 para-aminosalicylic_acid
thyX 3067559 c.387C>G synonymous_variant 0.23 para-aminosalicylic_acid
thyX 3067565 p.Asp127Glu missense_variant 0.22 para-aminosalicylic_acid
thyX 3067570 p.Ala126Pro missense_variant 0.22 para-aminosalicylic_acid
thyX 3067577 c.369G>A synonymous_variant 0.25 para-aminosalicylic_acid
thyX 3067601 p.Arg115His missense_variant 0.29 para-aminosalicylic_acid
thyX 3067611 p.Lys112Thr missense_variant 0.26 para-aminosalicylic_acid
thyX 3067619 c.327A>C synonymous_variant 0.25 para-aminosalicylic_acid
thyX 3067631 c.315C>G synonymous_variant 0.26 para-aminosalicylic_acid
thyX 3067634 c.312C>G synonymous_variant 0.27 para-aminosalicylic_acid
thyX 3067652 c.294T>C synonymous_variant 0.24 para-aminosalicylic_acid
thyX 3067661 c.285C>G synonymous_variant 0.21 para-aminosalicylic_acid
thyX 3067685 c.261A>C synonymous_variant 0.21 para-aminosalicylic_acid
thyX 3067691 p.Ile85Leu missense_variant 0.21 para-aminosalicylic_acid
thyX 3067694 c.252G>C synonymous_variant 0.21 para-aminosalicylic_acid
thyX 3067718 c.228C>G synonymous_variant 0.25 para-aminosalicylic_acid
thyX 3067721 c.225T>C synonymous_variant 0.25 para-aminosalicylic_acid
thyX 3067727 c.219A>C synonymous_variant 0.21 para-aminosalicylic_acid
thyX 3067736 p.Phe70Leu missense_variant 0.19 para-aminosalicylic_acid
thyX 3067739 c.207T>C synonymous_variant 0.19 para-aminosalicylic_acid
thyX 3067761 p.Arg62Lys missense_variant 0.18 para-aminosalicylic_acid
thyX 3067765 p.Leu61Ile missense_variant 0.18 para-aminosalicylic_acid
thyX 3067772 c.174C>G synonymous_variant 0.21 para-aminosalicylic_acid
thyX 3067781 c.165C>G synonymous_variant 0.21 para-aminosalicylic_acid
thyX 3067793 c.153T>C synonymous_variant 0.22 para-aminosalicylic_acid
thyX 3067799 c.147G>A synonymous_variant 0.18 para-aminosalicylic_acid
thyX 3067802 c.144C>G synonymous_variant 0.15 para-aminosalicylic_acid
thyA 3073917 c.555C>G synonymous_variant 0.16 para-aminosalicylic_acid
thyA 3073920 c.552C>G synonymous_variant 0.16 para-aminosalicylic_acid
thyA 3073925 c.547T>C synonymous_variant 0.16 para-aminosalicylic_acid
thyA 3073929 c.543T>C synonymous_variant 0.16 para-aminosalicylic_acid
thyA 3073953 c.519T>C synonymous_variant 0.2 para-aminosalicylic_acid
thyA 3073956 c.516G>C synonymous_variant 0.18 para-aminosalicylic_acid
thyA 3073959 c.513T>C synonymous_variant 0.19 para-aminosalicylic_acid
thyA 3074112 c.360C>G synonymous_variant 0.14 para-aminosalicylic_acid
thyA 3074127 c.345G>C synonymous_variant 0.15 para-aminosalicylic_acid
thyA 3074130 c.342G>C synonymous_variant 0.15 para-aminosalicylic_acid
thyA 3074154 c.318T>C synonymous_variant 0.19 para-aminosalicylic_acid
thyA 3074157 c.315C>G synonymous_variant 0.16 para-aminosalicylic_acid
thyA 3074160 c.312A>G synonymous_variant 0.16 para-aminosalicylic_acid
thyA 3074163 p.Ala103Thr missense_variant 0.17 para-aminosalicylic_acid
thyA 3074172 c.300G>C synonymous_variant 0.21 para-aminosalicylic_acid
thyA 3074175 c.297A>G synonymous_variant 0.21 para-aminosalicylic_acid
thyA 3074181 c.291A>G synonymous_variant 0.2 para-aminosalicylic_acid
thyA 3074187 c.285T>C synonymous_variant 0.2 para-aminosalicylic_acid
thyA 3074205 p.Glu89Asp missense_variant 0.2 para-aminosalicylic_acid
thyA 3074214 c.258T>C synonymous_variant 0.19 para-aminosalicylic_acid
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
Rv3236c 3612813 p.Thr102Ala missense_variant 0.94 pyrazinamide Not assoc w R - Interim
mtrB 3625065 p.Met517Leu missense_variant 1.0 rifampicin Not assoc w R
bedaquiline Uncertain significance
mtrB 3626562 p.Pro18Ser missense_variant 0.93 rifampicin Not assoc w R
bedaquiline Uncertain significance
mtrB 3626729 c.-116G>A upstream_gene_variant 0.17 rifampicin
bedaquiline
mtrB 3626732 c.-119A>G upstream_gene_variant 0.18 rifampicin
bedaquiline
mtrA 3626759 c.591T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626774 c.-163_-161delAGGinsCGC upstream_gene_variant 0.23 rifampicin
bedaquiline
mtrB 3626783 c.-170C>G upstream_gene_variant 0.22 rifampicin
bedaquiline
mtrA 3626786 c.564A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
bedaquiline
mtrA 3626792 c.558G>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626795 c.-182C>T upstream_gene_variant 0.2 rifampicin
bedaquiline
mtrB 3626798 c.-185T>C upstream_gene_variant 0.21 rifampicin
bedaquiline
mtrA 3626804 c.546A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627065 c.-452G>C upstream_gene_variant 0.21 rifampicin
bedaquiline
mtrA 3627068 c.282T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
bedaquiline
mtrA 3627071 c.279G>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627074 c.-461G>C upstream_gene_variant 0.21 rifampicin
bedaquiline
mtrA 3627080 c.270T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627083 c.-470G>C upstream_gene_variant 0.22 rifampicin
bedaquiline
mtrB 3627086 c.-473C>G upstream_gene_variant 0.23 rifampicin
bedaquiline
mtrA 3627098 c.252A>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627104 c.-491C>G upstream_gene_variant 0.3 rifampicin
bedaquiline
mtrA 3627119 c.231T>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627122 c.-509T>C upstream_gene_variant 0.33 rifampicin
bedaquiline
mtrB 3627167 c.-554T>C upstream_gene_variant 0.32 rifampicin
bedaquiline
mtrB 3627181 c.-568T>C upstream_gene_variant 0.33 rifampicin
bedaquiline
mtrB 3627182 c.-569T>C upstream_gene_variant 0.33 rifampicin
bedaquiline
mtrA 3627188 c.162A>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627209 c.-596G>A upstream_gene_variant 0.24 rifampicin
bedaquiline
mtrA 3627221 c.129C>T synonymous_variant 0.28 rifampicin Not assoc w R - Interim
bedaquiline
mtrA 3627227 c.123T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627233 c.-620T>C upstream_gene_variant 0.22 rifampicin
bedaquiline
mtrB 3627236 c.-623T>C upstream_gene_variant 0.22 rifampicin
bedaquiline
mtrA 3627242 c.108C>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627254 c.-641C>T upstream_gene_variant 0.24 rifampicin
bedaquiline
mtrB 3627263 c.-650C>T upstream_gene_variant 0.2 rifampicin
bedaquiline
mtrB 3627266 c.-653A>G upstream_gene_variant 0.18 rifampicin
bedaquiline
rpoA 3877494 p.Glu338Asp missense_variant 0.15 rifampicin Uncertain significance
rpoA 3877503 c.1005G>C synonymous_variant 0.18 rifampicin
rpoA 3877507 p.Gly334Ala missense_variant 0.18 rifampicin
rpoA 3877515 c.993G>C synonymous_variant 0.18 rifampicin
rpoA 3877553 p.Glu319Gln missense_variant 0.28 rifampicin
rpoA 3877571 p.Pro313Ala missense_variant 0.31 rifampicin
rpoA 3877587 c.921A>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoA 3877613 p.Ile299Val missense_variant 0.41 rifampicin
rpoA 3877617 c.891G>C synonymous_variant 0.4 rifampicin
rpoA 3877656 c.852T>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoA 3877668 c.840A>G synonymous_variant 0.25 rifampicin
rpoA 3877679 p.Ala277Ser missense_variant 0.23 rifampicin
rpoA 3877737 c.771G>C synonymous_variant 0.2 rifampicin
rpoA 3877743 c.765T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3877764 c.744C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoA 3877770 c.738A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoA 3877776 c.732T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoA 3877782 c.726T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3877963 p.Arg182Gln missense_variant 0.24 rifampicin Uncertain significance
ddn 3986636 c.-208C>G upstream_gene_variant 0.21 pretomanid
delamanid
clpC1 4038356 c.2349T>C synonymous_variant 0.19 pyrazinamide
clpC1 4038359 c.2346A>G synonymous_variant 0.18 pyrazinamide
clpC1 4038368 c.2337T>C synonymous_variant 0.17 pyrazinamide
clpC1 4038388 c.2317T>C synonymous_variant 0.2 pyrazinamide
clpC1 4038392 c.2313C>T synonymous_variant 0.22 pyrazinamide
clpC1 4038398 c.2307G>T synonymous_variant 0.24 pyrazinamide
clpC1 4038403 c.2302T>C synonymous_variant 0.26 pyrazinamide Not assoc w R - Interim
clpC1 4038407 c.2298G>C synonymous_variant 0.28 pyrazinamide
clpC1 4038419 c.2286T>C synonymous_variant 0.33 pyrazinamide
clpC1 4038433 c.2272C>T synonymous_variant 0.33 pyrazinamide
clpC1 4038434 c.2271G>A synonymous_variant 0.31 pyrazinamide
clpC1 4038444 p.Ala754Lys missense_variant 0.27 pyrazinamide
clpC1 4038446 c.2259T>C synonymous_variant 0.27 pyrazinamide
clpC1 4038456 p.Val750Glu missense_variant 0.24 pyrazinamide
clpC1 4038460 p.Leu749Met missense_variant 0.25 pyrazinamide
clpC1 4038486 p.Gly740Asn missense_variant 0.24 pyrazinamide
clpC1 4038489 p.Ala739Gly missense_variant 0.24 pyrazinamide
clpC1 4038494 c.2211G>C synonymous_variant 0.24 pyrazinamide
clpC1 4038497 p.Ser736Gln missense_variant 0.24 pyrazinamide
clpC1 4038509 c.2196C>T synonymous_variant 0.29 pyrazinamide
clpC1 4038530 p.Glu725Asp missense_variant 0.29 pyrazinamide
clpC1 4038596 c.2109A>G synonymous_variant 0.22 pyrazinamide
clpC1 4038623 c.2082A>G synonymous_variant 0.3 pyrazinamide
clpC1 4038640 p.Asp689Asn missense_variant 0.33 pyrazinamide
clpC1 4038647 c.2058T>C synonymous_variant 0.32 pyrazinamide
clpC1 4038653 c.2052C>T synonymous_variant 0.31 pyrazinamide
clpC1 4038658 p.Lys683Gln missense_variant 0.28 pyrazinamide
clpC1 4038661 p.Ser682Thr missense_variant 0.28 pyrazinamide
clpC1 4038662 c.2043T>C synonymous_variant 0.28 pyrazinamide
clpC1 4038671 c.2034T>C synonymous_variant 0.31 pyrazinamide
clpC1 4038683 c.2022T>C synonymous_variant 0.3 pyrazinamide Not assoc w R - Interim
clpC1 4038695 c.2010C>G synonymous_variant 0.33 pyrazinamide
clpC1 4038701 c.2004G>C synonymous_variant 0.34 pyrazinamide
clpC1 4038704 c.2001T>C synonymous_variant 0.32 pyrazinamide
clpC1 4038707 c.1998C>G synonymous_variant 0.32 pyrazinamide
clpC1 4038710 c.1995G>C synonymous_variant 0.31 pyrazinamide
clpC1 4038713 c.1992T>C synonymous_variant 0.32 pyrazinamide
clpC1 4038755 c.1950G>T synonymous_variant 0.41 pyrazinamide
clpC1 4038770 c.1935C>T synonymous_variant 0.4 pyrazinamide
clpC1 4038773 c.1932T>C synonymous_variant 0.39 pyrazinamide
clpC1 4038782 c.1923G>C synonymous_variant 0.39 pyrazinamide
clpC1 4038812 c.1893T>C synonymous_variant 0.42 pyrazinamide
clpC1 4038839 c.1866G>C synonymous_variant 0.41 pyrazinamide
clpC1 4038845 c.1860G>C synonymous_variant 0.43 pyrazinamide
clpC1 4038860 c.1845G>C synonymous_variant 0.46 pyrazinamide Not assoc w R - Interim
clpC1 4038878 c.1827A>G synonymous_variant 0.43 pyrazinamide Not assoc w R - Interim
clpC1 4038908 c.1797C>G synonymous_variant 0.46 pyrazinamide
clpC1 4038914 c.1791G>C synonymous_variant 0.46 pyrazinamide
clpC1 4038923 c.1782A>G synonymous_variant 0.46 pyrazinamide
clpC1 4038953 c.1752A>G synonymous_variant 0.46 pyrazinamide
clpC1 4038956 c.1749T>C synonymous_variant 0.46 pyrazinamide
clpC1 4038965 c.1740T>C synonymous_variant 0.45 pyrazinamide
clpC1 4038971 c.1734T>C synonymous_variant 0.43 pyrazinamide
clpC1 4038974 c.1731T>C synonymous_variant 0.43 pyrazinamide Not assoc w R - Interim
clpC1 4038989 c.1716T>C synonymous_variant 0.41 pyrazinamide
clpC1 4038997 c.1708T>C synonymous_variant 0.43 pyrazinamide Not assoc w R - Interim
clpC1 4039004 c.1701C>G synonymous_variant 0.44 pyrazinamide
clpC1 4039022 c.1683A>G synonymous_variant 0.43 pyrazinamide
clpC1 4039064 c.1641C>T synonymous_variant 0.34 pyrazinamide
clpC1 4039097 c.1608G>C synonymous_variant 0.26 pyrazinamide
clpC1 4039103 c.1602T>C synonymous_variant 0.26 pyrazinamide
clpC1 4039106 c.1599G>C synonymous_variant 0.27 pyrazinamide
clpC1 4039112 c.1593C>G synonymous_variant 0.26 pyrazinamide
clpC1 4039121 c.1584T>C synonymous_variant 0.27 pyrazinamide
clpC1 4039142 c.1563A>G synonymous_variant 0.22 pyrazinamide
clpC1 4039145 c.1560G>C synonymous_variant 0.2 pyrazinamide
clpC1 4039274 c.1431G>C synonymous_variant 0.29 pyrazinamide Not assoc w R - Interim
clpC1 4039286 c.1419T>C synonymous_variant 0.29 pyrazinamide
clpC1 4039295 c.1410A>C synonymous_variant 0.34 pyrazinamide
clpC1 4039298 c.1407T>C synonymous_variant 0.33 pyrazinamide
clpC1 4039319 c.1386T>C synonymous_variant 0.34 pyrazinamide Not assoc w R - Interim
clpC1 4039322 c.1383T>C synonymous_variant 0.33 pyrazinamide
clpC1 4039328 c.1377A>C synonymous_variant 0.34 pyrazinamide
clpC1 4039331 c.1374C>G synonymous_variant 0.32 pyrazinamide
clpC1 4039337 p.Thr456Gln missense_variant 0.31 pyrazinamide
clpC1 4039352 c.1353C>G synonymous_variant 0.32 pyrazinamide
clpC1 4039364 c.1341C>G synonymous_variant 0.32 pyrazinamide
clpC1 4039391 c.1314T>G synonymous_variant 0.25 pyrazinamide
clpC1 4039409 c.1296T>C synonymous_variant 0.17 pyrazinamide
clpC1 4039412 c.1293T>G synonymous_variant 0.17 pyrazinamide
clpC1 4039415 p.Glu430Asp missense_variant 0.17 pyrazinamide Uncertain significance
clpC1 4039430 c.1275T>C synonymous_variant 0.15 pyrazinamide
clpC1 4039517 c.1188C>G synonymous_variant 0.16 pyrazinamide
clpC1 4039556 c.1149G>C synonymous_variant 0.25 pyrazinamide
clpC1 4039559 c.1146C>G synonymous_variant 0.25 pyrazinamide
clpC1 4039562 c.1143C>G synonymous_variant 0.26 pyrazinamide
clpC1 4039565 c.1140G>C synonymous_variant 0.25 pyrazinamide
clpC1 4039570 p.Met379Leu missense_variant 0.26 pyrazinamide Uncertain significance
clpC1 4039576 p.Ala377Pro missense_variant 0.25 pyrazinamide
clpC1 4039577 c.1128T>C synonymous_variant 0.25 pyrazinamide Not assoc w R - Interim
clpC1 4039589 c.1116G>C synonymous_variant 0.25 pyrazinamide
clpC1 4039610 c.1095G>C synonymous_variant 0.31 pyrazinamide
clpC1 4039616 c.1089G>C synonymous_variant 0.33 pyrazinamide
clpC1 4039694 c.1011G>C synonymous_variant 0.16 pyrazinamide
clpC1 4040090 c.613_615delTCTinsAGC synonymous_variant 0.16 pyrazinamide
clpC1 4040093 c.612C>G synonymous_variant 0.16 pyrazinamide Not assoc w R - Interim
clpC1 4040105 c.600C>G synonymous_variant 0.16 pyrazinamide
clpC1 4040267 c.438A>G synonymous_variant 0.16 pyrazinamide Not assoc w R - Interim
clpC1 4040273 c.432T>C synonymous_variant 0.16 pyrazinamide Not assoc w R - Interim
clpC1 4040277 c.427_428delTCinsAG synonymous_variant 0.16 pyrazinamide
clpC1 4040279 c.426C>G synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
clpC1 4040291 c.414G>C synonymous_variant 0.24 pyrazinamide
clpC1 4040318 c.387C>G synonymous_variant 0.29 pyrazinamide
clpC1 4040330 c.375C>G synonymous_variant 0.27 pyrazinamide
clpC1 4040342 c.363C>G synonymous_variant 0.31 pyrazinamide
clpC1 4040354 c.351A>G synonymous_variant 0.34 pyrazinamide
clpC1 4040363 c.342A>T synonymous_variant 0.34 pyrazinamide
clpC1 4040369 c.336C>G synonymous_variant 0.33 pyrazinamide
clpC1 4040380 c.325T>C synonymous_variant 0.29 pyrazinamide
clpC1 4040381 c.324T>C synonymous_variant 0.3 pyrazinamide
clpC1 4040387 c.318A>G synonymous_variant 0.29 pyrazinamide
clpC1 4040393 c.312G>C synonymous_variant 0.28 pyrazinamide Not assoc w R - Interim
clpC1 4040411 c.294T>C synonymous_variant 0.23 pyrazinamide Not assoc w R - Interim
clpC1 4040423 c.282A>G synonymous_variant 0.16 pyrazinamide Not assoc w R - Interim
clpC1 4040426 c.279T>C synonymous_variant 0.16 pyrazinamide
clpC1 4040431 c.274T>C synonymous_variant 0.16 pyrazinamide
glpK 4138757 c.999A>G synonymous_variant 0.14 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
embC 4241022 p.Ala387Val missense_variant 0.94 ethambutol Uncertain significance
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
embA 4243460 c.228C>T synonymous_variant 1.0 ethambutol Not assoc w R
embA 4245257 c.2025A>G synonymous_variant 0.17 ethambutol
embA 4245263 c.2031A>G synonymous_variant 0.18 ethambutol Not assoc w R - Interim
embA 4245282 p.Ile684Val missense_variant 0.15 ethambutol
embB 4245659 c.-855C>G upstream_gene_variant 0.16 ethambutol
embA 4245674 c.2442A>C synonymous_variant 0.17 ethambutol Not assoc w R - Interim
embB 4245677 c.-837G>C upstream_gene_variant 0.17 ethambutol
embB 4247497 c.984T>C synonymous_variant 0.15 ethambutol
embB 4247512 c.999T>C synonymous_variant 0.16 ethambutol
embB 4248007 c.1494C>G synonymous_variant 0.16 ethambutol
embB 4248011 p.Ser500Pro missense_variant 0.15 ethambutol
embB 4248041 p.Ala510Thr missense_variant 0.15 ethambutol Uncertain significance
embB 4248044 p.Lys511Glu missense_variant 0.15 ethambutol
aftB 4267647 p.Asp397Gly missense_variant 0.98 ethambutol Not assoc w R
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 kanamycin
capreomycin
amikacin
gid 4407588 c.615A>G synonymous_variant 1.0 streptomycin Not assoc w R
gid 4407620 p.Tyr195His missense_variant 0.98 streptomycin Not assoc w R
gid 4407927 p.Glu92Asp missense_variant 1.0 streptomycin Not assoc w R