TB-Profiler result

Run: ERR502908
Summary

Run ID: ERR502908

Sample name:

Date: 2024-03-27T03:36:27.144056

Number of reads: 2450319

Percentage reads mapped: 83.84

Median coverage: 55.0

Strain: lineage2.2.1

Spoligotype:

Drug-resistance: HR-TB

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage2 East-Asian RD105 0.99
lineage2.2.1 East-Asian (Beijing) RD105;RD207;RD181 0.99
lineage2.2 East-Asian (Beijing) RD105;RD207 1.0
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid inhA c.-154G>A Assoc w R Alias fabG1_p.Leu203Leu. Low-level resistance (multiple, genetically linked low-level resistance mutations are additive and confer high-level resistance)
ethambutol
pyrazinamide
streptomycin rrs n.462C>T Uncertain significance Mutation from literature
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide inhA c.-154G>A Assoc w R - Interim Alias fabG1_p.Leu203Leu
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
rrs 1472307 n.462C>T non_coding_transcript_exon_variant 0.26 streptomycin Uncertain significance Mutation from literature
inhA 1674048 c.-154G>A upstream_gene_variant 0.98 ethionamide Assoc w R - Interim Alias fabG1_p.Leu203Leu
isoniazid Assoc w R Alias fabG1_p.Leu203Leu. Low-level resistance (multiple, genetically linked low-level resistance mutations are additive and confer high-level resistance)
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
dnaA 600 c.600T>G synonymous_variant 0.14 isoniazid
dnaA 1278 c.1278T>C synonymous_variant 0.17 isoniazid
dnaA 1284 c.1284C>G synonymous_variant 0.15 isoniazid
dnaA 1290 c.1290G>A synonymous_variant 0.16 isoniazid
dnaA 1293 c.1293T>C synonymous_variant 0.16 isoniazid
gyrB 6196 c.957C>T synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrB 6238 c.999G>A synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6250 c.1011A>G synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6256 c.1017G>A synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrB 6268 c.1029C>G synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrB 6280 c.1041T>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrB 6286 c.1047T>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrB 6289 c.1050C>T synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 6655 c.-647T>C upstream_gene_variant 0.15 levofloxacin
moxifloxacin
gyrA 6670 c.-632G>C upstream_gene_variant 0.15 levofloxacin
moxifloxacin
gyrA 6673 c.-629A>C upstream_gene_variant 0.16 levofloxacin
moxifloxacin
gyrA 6676 c.-626T>G upstream_gene_variant 0.15 levofloxacin
moxifloxacin
gyrA 7006 c.-296T>C upstream_gene_variant 0.17 levofloxacin
moxifloxacin
gyrA 7007 c.-295C>T upstream_gene_variant 0.17 levofloxacin
moxifloxacin
gyrA 7010 c.-292C>T upstream_gene_variant 0.17 levofloxacin
moxifloxacin
gyrA 7015 c.-287G>A upstream_gene_variant 0.17 levofloxacin
moxifloxacin
gyrA 7018 c.-284G>A upstream_gene_variant 0.17 levofloxacin
moxifloxacin
gyrB 7023 p.Leu595Gln missense_variant 0.17 levofloxacin
moxifloxacin
gyrA 7033 c.-269G>C upstream_gene_variant 0.18 levofloxacin
moxifloxacin
gyrA 7361 c.60C>T synonymous_variant 0.14 levofloxacin
moxifloxacin
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7391 c.90C>T synonymous_variant 0.13 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7394 c.93T>C synonymous_variant 0.14 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 8096 c.795T>A synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8099 c.798T>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8111 c.810G>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8121 c.820T>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8129 c.828T>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8135 c.834C>G synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8156 c.855T>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8168 c.867A>G synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8177 c.876A>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8264 c.963T>C synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 8276 c.975G>A synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 8283 c.982_984delATCinsCG frameshift_variant&missense_variant 0.17 levofloxacin
moxifloxacin
gyrA 8294 c.993T>C synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8324 c.1023T>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8330 c.1029C>G synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8339 c.1038A>G synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8340 p.Ala347Ser missense_variant 0.18 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8372 c.1071G>C synonymous_variant 0.14 levofloxacin
moxifloxacin
gyrA 8420 c.1119T>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8576 c.1275C>G synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 8579 c.1278C>T synonymous_variant 0.14 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8588 c.1287G>A synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 8597 c.1296C>G synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8603 c.1302A>G synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8636 c.1335A>C synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8642 c.1341A>G synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 9284 c.1983T>C synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 9291 c.1990C>T synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9323 c.2022C>G synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9335 c.2034G>C synonymous_variant 0.16 levofloxacin
moxifloxacin
fgd1 491742 c.960T>C synonymous_variant 1.0 clofazimine Not assoc w R
pretomanid
delamanid Not assoc w R - Interim
mshA 575907 p.Ala187Val missense_variant 0.96 ethionamide Not assoc w R
isoniazid Not assoc w R
ccsA 619609 c.-282G>C upstream_gene_variant 0.2 capreomycin
amikacin
kanamycin
ccsA 619634 c.-257T>A upstream_gene_variant 0.22 capreomycin
amikacin
kanamycin
ccsA 620625 p.Ile245Met missense_variant 1.0 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Uncertain significance
Rv0565c 656448 c.1021_1023delATTinsGC frameshift_variant&missense_variant 0.16 ethionamide Uncertain significance
Rv0565c 656454 c.1017G>C synonymous_variant 0.16 ethionamide
Rv0565c 656457 c.1014T>C synonymous_variant 0.16 ethionamide
Rv0565c 656469 c.1002T>C synonymous_variant 0.16 ethionamide
Rv0565c 656475 c.996A>G synonymous_variant 0.16 ethionamide
Rv0565c 657081 c.390G>A synonymous_variant 1.0 ethionamide Not assoc w R - Interim
Rv0565c 657142 p.Arg110His missense_variant 1.0 ethionamide Uncertain significance
Rv0565c 657342 c.129T>C synonymous_variant 0.13 ethionamide
nusG 734376 c.123G>A synonymous_variant 0.16 rifampicin
nusG 734407 c.154_156delGTTinsAC frameshift_variant&missense_variant 0.23 rifampicin
nusG 734421 c.168A>G synonymous_variant 0.24 rifampicin
nusG 734424 c.171G>A synonymous_variant 0.26 rifampicin
nusG 734442 c.189G>A synonymous_variant 0.29 rifampicin
nusG 734451 c.198G>C synonymous_variant 0.25 rifampicin
nusG 734457 c.204C>G synonymous_variant 0.24 rifampicin
nusG 734472 c.219T>C synonymous_variant 0.23 rifampicin
nusG 734475 c.222T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
nusG 734499 c.246G>C synonymous_variant 0.19 rifampicin
nusG 734532 c.279A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
nusG 734541 c.288A>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
nusG 734556 c.303C>T synonymous_variant 0.32 rifampicin
nusG 734559 c.306T>C synonymous_variant 0.32 rifampicin
nusG 734580 c.327T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
nusG 734589 c.336G>C synonymous_variant 0.25 rifampicin
nusG 734596 c.343T>C synonymous_variant 0.25 rifampicin
nusG 734601 c.348C>G synonymous_variant 0.22 rifampicin
nusG 734610 c.357C>G synonymous_variant 0.18 rifampicin
nusG 734625 c.372T>C synonymous_variant 0.16 rifampicin
rpoB 760121 c.315T>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 760130 p.Asp108Glu missense_variant 0.16 rifampicin Uncertain significance
rpoB 760139 c.333A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760142 c.336C>G synonymous_variant 0.19 rifampicin
rpoB 760181 c.375T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760184 c.378A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760196 c.390C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 760223 c.417T>C synonymous_variant 0.24 rifampicin
rpoB 760235 c.429T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760283 c.477G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 760298 c.492G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760307 c.501T>C synonymous_variant 0.17 rifampicin
rpoB 760310 c.504G>C synonymous_variant 0.18 rifampicin
rpoB 760328 c.522G>C synonymous_variant 0.22 rifampicin
rpoB 760331 c.525G>C synonymous_variant 0.22 rifampicin
rpoB 760340 c.534G>T synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 760361 c.555T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 760370 c.564C>G synonymous_variant 0.26 rifampicin
rpoB 760376 p.Asp190Glu missense_variant 0.26 rifampicin Uncertain significance
rpoB 760380 p.Thr192Leu missense_variant 0.25 rifampicin
rpoB 760406 c.600G>C synonymous_variant 0.25 rifampicin
rpoB 760412 c.606C>G synonymous_variant 0.26 rifampicin
rpoB 760424 c.618C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760430 c.624T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760481 c.675G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 760484 c.678A>G synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 760522 p.Ser239Asn missense_variant 0.21 rifampicin Uncertain significance
rpoB 760532 c.726T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760533 p.Val243Thr missense_variant 0.2 rifampicin
rpoB 760541 c.735G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760547 c.741G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760563 p.Arg253Met missense_variant 0.18 rifampicin Uncertain significance
rpoB 760591 p.Val262Ala missense_variant 0.2 rifampicin
rpoB 760674 c.868T>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 760793 c.987A>G synonymous_variant 0.19 rifampicin
rpoB 760805 c.999G>C synonymous_variant 0.19 rifampicin
rpoB 760817 c.1011A>G synonymous_variant 0.21 rifampicin
rpoB 760820 c.1014T>C synonymous_variant 0.19 rifampicin
rpoB 760826 c.1020C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760830 c.1024T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760841 c.1035T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760845 p.Thr347Pro missense_variant 0.23 rifampicin
rpoB 760859 c.1053T>C synonymous_variant 0.21 rifampicin
rpoB 760862 c.1056G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760869 p.Val355Ile missense_variant 0.22 rifampicin Uncertain significance
rpoB 760886 c.1080A>G synonymous_variant 0.18 rifampicin
rpoB 760925 c.1119T>C synonymous_variant 0.18 rifampicin
rpoB 760928 c.1122G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 760931 c.1125C>G synonymous_variant 0.16 rifampicin
rpoB 760934 c.1128C>T synonymous_variant 0.16 rifampicin
rpoB 760982 c.1176G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760985 c.1179G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760991 c.1185G>C synonymous_variant 0.24 rifampicin
rpoB 761006 c.1200C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 761015 c.1209G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 761021 c.1215G>C synonymous_variant 0.27 rifampicin
rpoB 761027 c.1221A>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 761036 c.1230G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 761037 c.1231T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 761057 c.1251G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 761102 c.1296A>G synonymous_variant 0.26 rifampicin
rpoB 761129 c.1323G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 761132 c.1326G>T synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 761133 c.1327T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 761150 c.1344A>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 761153 c.1347G>C synonymous_variant 0.31 rifampicin
rpoB 761165 c.1359G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 761180 c.1374A>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 761189 c.1383T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 761195 c.1389G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 761207 c.1401C>T synonymous_variant 0.28 rifampicin
rpoB 761213 c.1407G>C synonymous_variant 0.26 rifampicin
rpoB 761219 c.1413G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 761249 c.1443A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 761255 c.1449T>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 761261 c.1455G>T synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 761306 c.1500C>G synonymous_variant 0.27 rifampicin
rpoB 761327 c.1521A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 761330 c.1524G>C synonymous_variant 0.23 rifampicin
rpoB 761354 c.1548C>T synonymous_variant 0.22 rifampicin
rpoB 761360 c.1554T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 761362 p.Ser519Thr missense_variant 0.24 rifampicin
rpoB 761373 p.Val523His missense_variant 0.24 rifampicin
rpoB 761531 c.1725C>G synonymous_variant 0.24 rifampicin
rpoB 761537 c.1731C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761570 c.1764T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 761573 c.1767C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761579 c.1773G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 761588 c.1782C>T synonymous_variant 0.23 rifampicin
rpoB 761606 c.1800C>G synonymous_variant 0.18 rifampicin
rpoB 761612 c.1806G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 761615 c.1809A>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 761636 c.1830G>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 761645 c.1839C>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 761648 c.1842T>C synonymous_variant 0.15 rifampicin
rpoB 761657 c.1851C>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 761747 c.1941G>C synonymous_variant 0.15 rifampicin
rpoB 761750 c.1944G>C synonymous_variant 0.15 rifampicin
rpoB 761765 c.1959T>C synonymous_variant 0.15 rifampicin
rpoB 761873 c.2067A>C synonymous_variant 0.15 rifampicin
rpoB 761885 c.2079T>C synonymous_variant 0.2 rifampicin
rpoB 761906 c.2100C>G synonymous_variant 0.17 rifampicin
rpoB 761909 c.2103T>C synonymous_variant 0.17 rifampicin
rpoB 761912 c.2106T>C synonymous_variant 0.17 rifampicin
rpoB 761915 p.Asp703Glu missense_variant 0.17 rifampicin
rpoB 761916 p.Asp704Asn missense_variant 0.17 rifampicin
rpoB 761948 c.2142G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 761954 c.2148C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 762008 c.2202C>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 762014 c.2208C>T synonymous_variant 0.24 rifampicin
rpoB 762017 c.2211A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 762053 c.2247T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 762062 c.2256T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 762083 c.2277T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 762086 c.2280G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 762206 c.2400C>G synonymous_variant 0.3 rifampicin
rpoB 762233 c.2427G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 762246 c.2440C>T synonymous_variant 0.27 rifampicin
rpoB 762254 c.2448T>G synonymous_variant 0.26 rifampicin
rpoB 762257 c.2451C>G synonymous_variant 0.26 rifampicin
rpoB 762266 c.2460T>C synonymous_variant 0.28 rifampicin
rpoB 762284 c.2478G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 762293 c.2487T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 762314 c.2508C>T synonymous_variant 0.21 rifampicin
rpoB 762317 c.2511A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 762329 c.2523G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 762338 c.2532T>C synonymous_variant 0.2 rifampicin
rpoB 762347 c.2541T>C synonymous_variant 0.2 rifampicin
rpoB 762362 p.Glu852Asp missense_variant 0.19 rifampicin
rpoB 762369 c.2563T>C synonymous_variant 0.2 rifampicin
rpoC 762395 c.-975G>C upstream_gene_variant 0.17 rifampicin
rpoC 762398 c.-972T>C upstream_gene_variant 0.16 rifampicin
rpoC 762401 c.-969G>C upstream_gene_variant 0.16 rifampicin
rpoB 762404 c.2598T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 762410 c.2604T>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 762413 c.2607G>A synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 762416 c.2610A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 762419 c.-951C>G upstream_gene_variant 0.17 rifampicin
rpoC 762434 c.-936T>C upstream_gene_variant 0.14 rifampicin
rpoB 762857 c.3051C>G synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 762863 c.3057T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 762929 c.3123G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 762989 c.-381G>C upstream_gene_variant 0.25 rifampicin
rpoB 762995 c.3189G>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 763013 c.-357C>G upstream_gene_variant 0.24 rifampicin
rpoB 763028 c.3222T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>C synonymous_variant 0.78 rifampicin Not assoc w R
rpoB 763031 c.3225T>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 763034 c.3228C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 763040 c.3234C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 763070 c.3264T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 763085 c.3279C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 763115 c.3309T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 763402 c.33C>G synonymous_variant 0.16 rifampicin
rpoC 763411 c.42T>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 763414 c.45T>C synonymous_variant 0.17 rifampicin
rpoC 763441 c.72C>T synonymous_variant 0.22 rifampicin
rpoC 763444 c.75T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 763456 c.87A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 763486 c.117T>G synonymous_variant 0.26 rifampicin
rpoC 763492 c.123G>A synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 763528 c.159G>A synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 763573 c.204G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 763594 c.225C>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 763603 c.234C>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 763636 c.267T>C synonymous_variant 0.24 rifampicin
rpoC 763657 c.288G>A synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 763660 c.291T>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 763675 c.306C>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 763696 c.327T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 763702 c.333C>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 763717 c.348T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 763723 c.354G>C synonymous_variant 0.26 rifampicin
rpoC 763732 c.363C>G synonymous_variant 0.23 rifampicin
rpoC 763738 c.369G>A synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 763741 c.372C>T synonymous_variant 0.21 rifampicin
rpoC 763744 c.375G>C synonymous_variant 0.21 rifampicin
rpoC 763765 c.396T>C synonymous_variant 0.23 rifampicin
rpoC 763774 c.405G>C synonymous_variant 0.19 rifampicin
rpoC 763807 c.438T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 763816 c.447C>G synonymous_variant 0.14 rifampicin
rpoC 763835 p.Ala156Met missense_variant 0.15 rifampicin
rpoC 763872 p.Gly168Ala missense_variant 0.15 rifampicin
rpoC 763876 p.Glu169Asp missense_variant 0.14 rifampicin
rpoC 763879 c.510A>G synonymous_variant 0.17 rifampicin
rpoC 763945 c.576T>C synonymous_variant 0.17 rifampicin
rpoC 763951 c.582G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 763960 c.591T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 763987 c.618C>T synonymous_variant 0.16 rifampicin
rpoC 763991 c.622_624delATCinsCG frameshift_variant&missense_variant 0.16 rifampicin
rpoC 763996 c.627T>C synonymous_variant 0.16 rifampicin
rpoC 764002 c.633C>G synonymous_variant 0.15 rifampicin
rpoC 764005 c.636G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 764083 c.714A>G synonymous_variant 0.21 rifampicin
rpoC 764098 c.729A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 764101 c.732C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 764102 p.Val245Ile missense_variant 0.24 rifampicin
rpoC 764112 p.Tyr248Phe missense_variant 0.25 rifampicin
rpoC 764116 c.747C>T synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 764131 c.762T>C synonymous_variant 0.26 rifampicin
rpoC 764188 c.819A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764195 p.Ser276Ile missense_variant 0.16 rifampicin
rpoC 764203 c.834G>C synonymous_variant 0.2 rifampicin
rpoC 764206 c.837T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764215 c.846A>G synonymous_variant 0.23 rifampicin
rpoC 764236 c.867G>A synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 764248 c.879C>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 764257 c.888G>C synonymous_variant 0.22 rifampicin
rpoC 764266 c.897T>C synonymous_variant 0.23 rifampicin
rpoC 764269 c.900G>C synonymous_variant 0.22 rifampicin
rpoC 764272 c.903G>C synonymous_variant 0.21 rifampicin
rpoC 764278 c.909A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764446 c.1077T>C synonymous_variant 0.14 rifampicin
rpoC 764449 c.1080G>C synonymous_variant 0.14 rifampicin
rpoC 764452 c.1083T>C synonymous_variant 0.15 rifampicin
rpoC 764458 c.1089G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764461 c.1092A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764489 c.1120C>T synonymous_variant 0.19 rifampicin
rpoC 764497 c.1128A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764510 c.1141C>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>C synonymous_variant 0.16 rifampicin
rpoC 764651 c.1282_1284delTCGinsAGC synonymous_variant 0.16 rifampicin
rpoC 764752 c.1383G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764764 c.1395T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764809 c.1440C>T synonymous_variant 0.25 rifampicin Not assoc w R
rpoC 764815 c.1446A>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764827 c.1458G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 764858 c.1489T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764872 c.1503A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764888 c.1519T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764911 c.1542A>G synonymous_variant 0.14 rifampicin
rpoC 765034 c.1665T>C synonymous_variant 0.15 rifampicin
rpoC 765040 c.1671T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 765041 c.1672T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 765055 c.1686C>G synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 765352 c.1983G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 765383 p.Met672Leu missense_variant 0.18 rifampicin Uncertain significance
rpoC 765404 p.Leu679Val missense_variant 0.18 rifampicin
rpoC 765409 c.2040T>C synonymous_variant 0.17 rifampicin
rpoC 765421 c.2052C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 765451 c.2082C>A synonymous_variant 0.26 rifampicin
rpoC 765478 c.2109T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 765499 c.2130C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 765529 c.2160C>T synonymous_variant 0.18 rifampicin
rpoC 765541 c.2172C>G synonymous_variant 0.2 rifampicin
rpoC 765553 c.2184C>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 765556 c.2187G>C synonymous_variant 0.17 rifampicin
rpoC 765559 c.2190G>C synonymous_variant 0.17 rifampicin
rpoC 765580 c.2211G>C synonymous_variant 0.21 rifampicin
rpoC 765613 p.His748Gln missense_variant 0.22 rifampicin
rpoC 765625 c.2256C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 765631 p.Asp754Glu missense_variant 0.2 rifampicin
rpoC 765700 c.2331T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 765734 c.2365T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 765739 c.2370G>T synonymous_variant 0.24 rifampicin
rpoC 765772 c.2403C>G synonymous_variant 0.24 rifampicin
rpoC 765784 c.2415C>G synonymous_variant 0.22 rifampicin
rpoC 765787 c.2418C>T synonymous_variant 0.22 rifampicin
rpoC 765793 c.2424C>G synonymous_variant 0.24 rifampicin
rpoC 765796 c.2427C>T synonymous_variant 0.24 rifampicin
rpoC 765811 c.2442T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 765814 c.2445A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 765826 c.2457T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 765835 c.2466C>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 765850 c.2481G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 765883 c.2514C>G synonymous_variant 0.21 rifampicin
rpoC 765886 c.2517C>G synonymous_variant 0.21 rifampicin
rpoC 765892 c.2523T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 765937 c.2568T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 765947 c.2578T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 765967 c.2598C>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 765982 c.2613C>G synonymous_variant 0.22 rifampicin
rpoC 765994 c.2625A>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 766010 c.2641_2642delTCinsAG synonymous_variant 0.19 rifampicin
rpoC 766021 c.2652G>C synonymous_variant 0.2 rifampicin
rpoC 766027 c.2658G>C synonymous_variant 0.2 rifampicin
rpoC 766043 p.Gln892Glu missense_variant 0.2 rifampicin
rpoC 766054 c.2685C>G synonymous_variant 0.15 rifampicin
rpoC 766096 c.2727G>C synonymous_variant 0.15 rifampicin
rpoC 766384 c.3015A>G synonymous_variant 0.15 rifampicin
rpoC 766390 c.3021C>T synonymous_variant 0.15 rifampicin
rpoC 766393 c.3024C>G synonymous_variant 0.16 rifampicin
rpoC 766726 c.3357T>C synonymous_variant 0.15 rifampicin
rpoC 766765 c.3396A>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 766774 c.3405T>C synonymous_variant 0.15 rifampicin
rpoC 766804 c.3435A>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 766861 c.3492G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 766864 c.3495G>C synonymous_variant 0.19 rifampicin
rpoC 766933 c.3564A>G synonymous_variant 0.18 rifampicin
rpoC 766945 c.3576A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 766963 c.3594T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 766972 c.3603G>C synonymous_variant 0.16 rifampicin
rpoC 767098 c.3729T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 767119 c.3750A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 767134 c.3765C>A synonymous_variant 0.25 rifampicin
rpoC 767158 c.3789T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 767180 p.Ala1271Gln missense_variant 0.19 rifampicin
rpoC 767191 c.3822C>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 767221 c.3852C>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 767233 c.3864T>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
mmpL5 775639 p.Ile948Val missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
mmpL5 776100 p.Thr794Ile missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
mmpL5 776182 p.Asp767Asn missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R
mmpS5 779615 c.-710C>G upstream_gene_variant 1.0 clofazimine
bedaquiline
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781628 c.69T>C synonymous_variant 0.2 streptomycin Not assoc w R - Interim
rpsL 781631 c.72G>C synonymous_variant 0.2 streptomycin
rpsL 781649 c.90T>C synonymous_variant 0.21 streptomycin
rpsL 781655 c.96T>C synonymous_variant 0.23 streptomycin
rpsL 781682 c.123T>C synonymous_variant 0.25 streptomycin
rpsL 781700 c.141G>C synonymous_variant 0.23 streptomycin
rpsL 781703 c.144G>T synonymous_variant 0.23 streptomycin
rpsL 781715 c.156T>C synonymous_variant 0.24 streptomycin
rpsL 781728 c.169T>C synonymous_variant 0.19 streptomycin
rpsL 781736 c.177T>C synonymous_variant 0.21 streptomycin
rpsL 781742 c.183C>T synonymous_variant 0.21 streptomycin
rpsL 781748 c.189C>G synonymous_variant 0.22 streptomycin
rpsL 781754 c.195G>C synonymous_variant 0.19 streptomycin
rpsL 781760 c.201T>C synonymous_variant 0.19 streptomycin
rpsL 781772 c.213C>A synonymous_variant 0.19 streptomycin
rpsL 781808 c.249C>T synonymous_variant 0.19 streptomycin
rpsL 781811 c.252C>T synonymous_variant 0.2 streptomycin
rpsL 781832 c.273T>C synonymous_variant 0.14 streptomycin
rpsL 781838 c.279G>C synonymous_variant 0.18 streptomycin
rpsL 781841 c.282C>G synonymous_variant 0.18 streptomycin
rpsL 781865 c.306G>C synonymous_variant 0.19 streptomycin
rpsL 781868 c.309T>C synonymous_variant 0.19 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.19 streptomycin
rpsL 781877 c.318T>C synonymous_variant 0.19 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.2 streptomycin
rpsL 781898 c.339A>T synonymous_variant 0.18 streptomycin
rpsL 781916 c.357T>C synonymous_variant 0.18 streptomycin
rpsL 781929 p.Gly124Ser missense_variant 0.21 streptomycin Uncertain significance
rplC 800567 c.-242A>G upstream_gene_variant 0.2 linezolid
rplC 800582 c.-227C>G upstream_gene_variant 0.19 linezolid
rplC 800612 c.-197A>G upstream_gene_variant 0.15 linezolid
rplC 800618 c.-191T>C upstream_gene_variant 0.17 linezolid
rplC 800627 c.-182C>T upstream_gene_variant 0.19 linezolid
rplC 800648 c.-161A>T upstream_gene_variant 0.16 linezolid
rplC 800654 c.-155T>C upstream_gene_variant 0.16 linezolid
rplC 800693 c.-116A>G upstream_gene_variant 0.15 linezolid
rplC 800703 c.-106T>C upstream_gene_variant 0.19 linezolid
rplC 800715 c.-94A>C upstream_gene_variant 0.16 linezolid
rplC 800720 c.-89T>C upstream_gene_variant 0.18 linezolid
rplC 800723 c.-86C>G upstream_gene_variant 0.17 linezolid
rplC 800747 c.-62C>G upstream_gene_variant 0.17 linezolid
rplC 800771 c.-38C>T upstream_gene_variant 0.17 linezolid
rplC 800794 c.-15A>G upstream_gene_variant 0.17 linezolid
rplC 800796 c.-13A>G upstream_gene_variant 0.17 linezolid
rplC 800798 c.-10_-9delGG upstream_gene_variant 0.17 linezolid
rplC 800814 c.6A>G synonymous_variant 0.21 linezolid
rplC 800817 c.9A>T synonymous_variant 0.22 linezolid
rplC 800844 c.36T>C synonymous_variant 0.26 linezolid
rplC 800865 c.57A>G synonymous_variant 0.18 linezolid
Rv1129c 1254562 c.-28T>C upstream_gene_variant 1.0 moxifloxacin Not assoc w R
levofloxacin Not assoc w R
rifampicin Not assoc w R
isoniazid Not assoc w R
fbiC 1304565 c.1635C>G synonymous_variant 0.14 clofazimine
pretomanid
delamanid
fbiC 1304568 c.1638T>C synonymous_variant 0.15 clofazimine
pretomanid
delamanid
fbiC 1304580 c.1650T>C synonymous_variant 0.15 clofazimine
pretomanid
delamanid
fbiC 1304613 c.1683T>C synonymous_variant 0.15 clofazimine
pretomanid
delamanid
fbiC 1304787 c.1857T>G synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1304808 c.1878C>G synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fbiC 1304811 c.1881C>G synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fbiC 1304817 c.1887T>C synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fbiC 1304829 c.1899T>C synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1304832 c.1902C>T synonymous_variant 0.23 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1304853 c.1923C>T synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1304856 c.1926C>G synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1304869 c.1939C>T synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1304875 p.Ile649Val missense_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1304883 p.Glu651Asp missense_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1304891 p.Ile654Thr missense_variant 0.15 clofazimine
pretomanid
delamanid
fbiC 1304893 p.Gly655Ser missense_variant 0.14 clofazimine
pretomanid
delamanid
fbiC 1304937 c.2007G>C synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1304958 c.2028T>G synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1304983 c.2053C>T synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1304994 c.2064A>G synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1304995 p.Leu689Met missense_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1305006 c.2076A>G synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1305012 c.2082G>C synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1305015 c.2085G>C synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1305021 c.2091C>G synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1305030 c.2100G>C synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1305033 c.2103T>G synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1305042 c.2112A>G synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1305063 c.2133G>C synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1305066 c.2136T>C synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1305069 c.2139G>C synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1305114 c.2184T>C synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1305117 c.2187T>C synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1305252 c.2322G>A synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1305276 c.2346G>C synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1305279 p.His783Gln missense_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1305282 c.2352T>C synonymous_variant 0.2 clofazimine
pretomanid
delamanid
Rv1258c 1406760 c.580_581insC frameshift_variant 1.0 streptomycin Uncertain significance
isoniazid Uncertain significance
pyrazinamide Uncertain significance
atpE 1460831 c.-214T>C upstream_gene_variant 0.17 bedaquiline
atpE 1460852 c.-193C>G upstream_gene_variant 0.16 bedaquiline
atpE 1460855 c.-190T>C upstream_gene_variant 0.16 bedaquiline
atpE 1460858 c.-187C>G upstream_gene_variant 0.16 bedaquiline
atpE 1460861 c.-184C>G upstream_gene_variant 0.15 bedaquiline
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471923 n.78T>C non_coding_transcript_exon_variant 0.18 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471925 n.80T>C non_coding_transcript_exon_variant 0.18 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471932 n.87A>G non_coding_transcript_exon_variant 0.2 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471934 n.89A>G non_coding_transcript_exon_variant 0.21 streptomycin Uncertain significance
kanamycin
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471969 n.124T>C non_coding_transcript_exon_variant 0.16 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471970 n.125G>A non_coding_transcript_exon_variant 0.16 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473105 n.1260G>A non_coding_transcript_exon_variant 0.15 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473123 n.1278delAinsTT non_coding_transcript_exon_variant 0.17 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.19 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.16 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473290 n.1445C>T non_coding_transcript_exon_variant 0.22 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrl 1473806 n.149C>T non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473877 n.220G>A non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
rrl 1473943 n.286G>T non_coding_transcript_exon_variant 0.14 capreomycin Uncertain significance
linezolid
rrl 1473945 n.288T>A non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid
rrl 1473946 n.289A>T non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid
rrl 1473986 n.329T>C non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1473987 n.330G>A non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1473995 n.338G>T non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1474001 n.344C>T non_coding_transcript_exon_variant 0.27 capreomycin Not assoc w R
linezolid Not assoc w R
rrl 1474009 n.352A>G non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1474012 n.355C>T non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1474093 n.436G>T non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
rrl 1474099 n.442G>A non_coding_transcript_exon_variant 0.15 capreomycin
linezolid
rrl 1474103 n.446A>T non_coding_transcript_exon_variant 0.15 capreomycin
linezolid
rrl 1474140 n.483C>T non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474181 n.524C>T non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474291 n.635_649delTTCCTCTCCGGAGGA non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1474308 n.651G>T non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474310 n.653T>G non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1474356 n.699T>C non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid
rrl 1474639 n.982G>A non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474823 n.1166C>T non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
rrl 1474831 n.1174A>G non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid
rrl 1474904 n.1247G>A non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1474956 n.1299C>T non_coding_transcript_exon_variant 0.14 capreomycin
linezolid
rrl 1474970 n.1313G>A non_coding_transcript_exon_variant 0.13 capreomycin
linezolid
rrl 1475006 n.1349A>T non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1475061 n.1404C>T non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid
rrl 1475088 n.1431A>T non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1475199 n.1542G>A non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1475206 n.1549C>T non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid
rrl 1475209 n.1552G>C non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid
rrl 1475213 n.1556C>T non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid
rrl 1475249 n.1592T>C non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475252 n.1595C>T non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1475266 n.1609T>C non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475267 n.1610G>A non_coding_transcript_exon_variant 0.13 capreomycin
linezolid
rrl 1475275 n.1618C>T non_coding_transcript_exon_variant 0.13 capreomycin
linezolid
rrl 1475291 n.1634A>C non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475315 n.1658A>T non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475355 n.1698C>T non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475369 n.1712G>T non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1475483 n.1826C>T non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475505 n.1848G>A non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid
rrl 1475599 n.1942A>G non_coding_transcript_exon_variant 0.16 capreomycin
linezolid Uncertain significance
rrl 1475608 n.1951T>C non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid
rrl 1475642 n.1985T>C non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
rrl 1475657 n.2000A>G non_coding_transcript_exon_variant 0.15 capreomycin
linezolid
rrl 1475659 n.2002G>T non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
rrl 1475881 n.2224T>C non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1476214 n.2557G>A non_coding_transcript_exon_variant 0.15 capreomycin
linezolid
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476583 n.2926G>A non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.23 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476594 n.2937C>T non_coding_transcript_exon_variant 0.26 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476597 n.2940G>A non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid
rrl 1476603 n.2946G>A non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476608 n.2951C>G non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476716 n.3059A>C non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid
rrl 1476726 n.3069A>G non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
rrl 1476732 n.3075T>C non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
rrl 1476755 n.3098G>A non_coding_transcript_exon_variant 0.12 capreomycin
linezolid
inhA 1674846 p.Ile215Met missense_variant 0.17 ethionamide
isoniazid
inhA 1674855 c.654C>G synonymous_variant 0.17 ethionamide
isoniazid Not assoc w R - Interim
inhA 1674903 c.702T>C synonymous_variant 0.15 ethionamide
isoniazid
inhA 1674904 p.Ala235Pro missense_variant 0.15 ethionamide
isoniazid
inhA 1674909 c.708G>A synonymous_variant 0.14 ethionamide
isoniazid
rpsA 1833595 c.54T>C synonymous_variant 0.14 pyrazinamide
rpsA 1833661 c.120A>G synonymous_variant 0.17 pyrazinamide
rpsA 1833667 c.126C>G synonymous_variant 0.17 pyrazinamide
rpsA 1833838 c.297G>C synonymous_variant 0.21 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.24 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.23 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.22 pyrazinamide
rpsA 1833874 c.333T>C synonymous_variant 0.24 pyrazinamide
rpsA 1833971 c.430C>T synonymous_variant 0.15 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.16 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.15 pyrazinamide
rpsA 1834021 c.480C>T synonymous_variant 0.14 pyrazinamide
rpsA 1834177 c.636A>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
rpsA 1834249 c.708T>C synonymous_variant 0.14 pyrazinamide
rpsA 1834333 c.792C>T synonymous_variant 0.16 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 0.15 pyrazinamide Not assoc w R - Interim
rpsA 1834609 c.1068T>C synonymous_variant 0.16 pyrazinamide
rpsA 1834639 c.1098T>C synonymous_variant 0.14 pyrazinamide
tsnR 1853387 c.-219T>G upstream_gene_variant 0.16 linezolid
tsnR 1853420 c.-186T>G upstream_gene_variant 0.15 linezolid
tsnR 1853429 c.-177G>C upstream_gene_variant 0.15 linezolid
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
katG 2154724 p.Arg463Leu missense_variant 1.0 isoniazid Not assoc w R
katG 2155171 p.Thr314Asn missense_variant 0.98 isoniazid
PPE35 2167926 p.Leu896Ser missense_variant 1.0 pyrazinamide Not assoc w R
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
kasA 2517950 c.-165C>G upstream_gene_variant 0.2 isoniazid
kasA 2518174 c.60A>G synonymous_variant 0.17 isoniazid
kasA 2518190 p.Ser26Ala missense_variant 0.21 isoniazid
kasA 2518199 p.Ile29Val missense_variant 0.22 isoniazid
kasA 2518220 c.106C>T synonymous_variant 0.19 isoniazid
kasA 2518234 c.120G>A synonymous_variant 0.15 isoniazid
kasA 2518248 p.Ala45Val missense_variant 0.15 isoniazid
kasA 2518519 c.405G>C synonymous_variant 0.2 isoniazid
kasA 2518528 c.414C>G synonymous_variant 0.2 isoniazid
kasA 2518696 c.582C>G synonymous_variant 0.15 isoniazid
kasA 2518744 c.630C>T synonymous_variant 0.18 isoniazid
kasA 2518747 c.633C>G synonymous_variant 0.19 isoniazid
kasA 2518768 c.654C>T synonymous_variant 0.21 isoniazid
kasA 2518777 c.663C>T synonymous_variant 0.22 isoniazid
kasA 2518783 c.669T>C synonymous_variant 0.2 isoniazid
kasA 2518789 c.675G>C synonymous_variant 0.16 isoniazid
kasA 2518792 c.678C>A synonymous_variant 0.14 isoniazid
kasA 2518795 c.681C>G synonymous_variant 0.15 isoniazid
kasA 2518825 c.711T>C synonymous_variant 0.15 isoniazid
kasA 2518864 c.750G>C synonymous_variant 0.16 isoniazid
kasA 2518879 c.765A>G synonymous_variant 0.19 isoniazid
kasA 2518885 c.771T>C synonymous_variant 0.18 isoniazid
kasA 2518898 c.784T>C synonymous_variant 0.19 isoniazid
kasA 2518906 c.792A>G synonymous_variant 0.18 isoniazid
kasA 2518910 p.Leu266Met missense_variant 0.18 isoniazid
kasA 2518921 c.807T>C synonymous_variant 0.18 isoniazid
folC 2747266 c.333C>T synonymous_variant 0.13 para-aminosalicylic_acid
folC 2747275 c.324T>C synonymous_variant 0.16 para-aminosalicylic_acid
folC 2747289 p.Pro104Ala missense_variant 0.15 para-aminosalicylic_acid
folC 2747290 c.309A>G synonymous_variant 0.15 para-aminosalicylic_acid
folC 2747293 c.306G>A synonymous_variant 0.15 para-aminosalicylic_acid
folC 2747302 c.297A>G synonymous_variant 0.18 para-aminosalicylic_acid
folC 2747314 c.285A>C synonymous_variant 0.2 para-aminosalicylic_acid
folC 2747317 c.282C>G synonymous_variant 0.19 para-aminosalicylic_acid
folC 2747343 p.Val86Ile missense_variant 0.13 para-aminosalicylic_acid
Rv2477c 2783182 c.861C>G synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783185 c.858G>A synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783194 c.849A>G synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783221 c.822G>C synonymous_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783224 c.819C>G synonymous_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783230 c.813T>G synonymous_variant 0.2 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783235 c.808T>C synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783254 c.789A>G synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783263 c.780G>C synonymous_variant 0.14 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783563 c.480A>G synonymous_variant 0.14 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783572 c.471A>G synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783656 c.387G>C synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783665 c.378A>G synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783683 c.360A>G synonymous_variant 0.14 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783953 c.90G>A synonymous_variant 0.16 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783962 c.81T>C synonymous_variant 0.2 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783971 c.72G>C synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783980 c.63C>G synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783992 c.51T>C synonymous_variant 0.14 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin
Rv2752c 3065955 p.Leu79Phe missense_variant 0.14 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
thyX 3067379 c.567C>T synonymous_variant 0.14 para-aminosalicylic_acid
thyX 3067718 c.228C>G synonymous_variant 0.17 para-aminosalicylic_acid
thyX 3067721 c.225T>C synonymous_variant 0.17 para-aminosalicylic_acid
thyX 3067727 c.219A>C synonymous_variant 0.18 para-aminosalicylic_acid
thyX 3067736 c.210C>T synonymous_variant 0.2 para-aminosalicylic_acid
thyX 3067761 p.Arg62Lys missense_variant 0.19 para-aminosalicylic_acid
thyX 3067765 p.Leu61Ile missense_variant 0.19 para-aminosalicylic_acid
thyX 3067781 c.165C>G synonymous_variant 0.19 para-aminosalicylic_acid
thyX 3067793 c.153T>C synonymous_variant 0.17 para-aminosalicylic_acid
thyX 3067799 c.147G>A synonymous_variant 0.18 para-aminosalicylic_acid
thyX 3067802 c.144C>G synonymous_variant 0.16 para-aminosalicylic_acid
thyX 3067814 c.132T>C synonymous_variant 0.18 para-aminosalicylic_acid
thyX 3067850 c.96A>C synonymous_variant 0.18 para-aminosalicylic_acid
thyX 3067869 p.Thr26Ser missense_variant 0.28 para-aminosalicylic_acid
thyX 3067874 c.72C>G synonymous_variant 0.27 para-aminosalicylic_acid
thyX 3067877 c.69G>C synonymous_variant 0.26 para-aminosalicylic_acid
thyX 3067883 c.63C>G synonymous_variant 0.25 para-aminosalicylic_acid
thyX 3067886 c.60A>C synonymous_variant 0.22 para-aminosalicylic_acid
thyX 3067889 c.57C>G synonymous_variant 0.23 para-aminosalicylic_acid
thyX 3067898 p.Asp16Glu missense_variant 0.22 para-aminosalicylic_acid
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
Rv3236c 3612813 p.Thr102Ala missense_variant 1.0 pyrazinamide Not assoc w R - Interim
mtrB 3625065 p.Met517Leu missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
lpqB 3625602 c.-692T>C upstream_gene_variant 0.14 bedaquiline
rifampicin
lpqB 3625612 c.-702G>C upstream_gene_variant 0.14 bedaquiline
rifampicin
mtrB 3625616 p.Arg333Ala missense_variant 0.15 bedaquiline
rifampicin
lpqB 3625624 c.-714C>G upstream_gene_variant 0.18 bedaquiline
rifampicin
lpqB 3625864 c.-954T>G upstream_gene_variant 0.16 bedaquiline
rifampicin
mtrB 3625876 c.738G>C synonymous_variant 0.14 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626562 p.Pro18Ser missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
mtrB 3626927 c.-314G>C upstream_gene_variant 0.16 bedaquiline
rifampicin
mtrB 3626930 c.-317A>G upstream_gene_variant 0.16 bedaquiline
rifampicin
mtrB 3626957 c.-344G>C upstream_gene_variant 0.15 bedaquiline
rifampicin
mtrB 3626972 c.-359A>G upstream_gene_variant 0.18 bedaquiline
rifampicin
mtrB 3626987 c.-374C>G upstream_gene_variant 0.17 bedaquiline
rifampicin
mtrB 3627008 c.-395G>C upstream_gene_variant 0.21 bedaquiline
rifampicin
mtrB 3627011 c.-398T>G upstream_gene_variant 0.21 bedaquiline
rifampicin
mtrB 3627065 c.-452G>C upstream_gene_variant 0.15 bedaquiline
rifampicin
mtrA 3627068 c.282T>C synonymous_variant 0.15 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3627071 c.279G>T synonymous_variant 0.15 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627074 c.-461G>C upstream_gene_variant 0.15 bedaquiline
rifampicin
mtrA 3627080 c.270T>C synonymous_variant 0.15 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627083 c.-470G>C upstream_gene_variant 0.15 bedaquiline
rifampicin
mtrA 3627146 c.204C>T synonymous_variant 0.15 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627167 c.-554T>C upstream_gene_variant 0.18 bedaquiline
rifampicin
mtrB 3627181 c.-568T>C upstream_gene_variant 0.17 bedaquiline
rifampicin
mtrB 3627182 c.-569T>C upstream_gene_variant 0.17 bedaquiline
rifampicin
mtrA 3627188 c.162A>G synonymous_variant 0.16 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627209 c.-596G>A upstream_gene_variant 0.16 bedaquiline
rifampicin
mtrA 3627221 c.129C>T synonymous_variant 0.17 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3627227 c.123T>C synonymous_variant 0.15 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3627242 c.108C>T synonymous_variant 0.13 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627272 c.-659G>T upstream_gene_variant 0.16 bedaquiline
rifampicin
mtrB 3627275 c.-662G>T upstream_gene_variant 0.16 bedaquiline
rifampicin
mtrB 3627296 c.-683T>C upstream_gene_variant 0.15 bedaquiline
rifampicin
mtrA 3627299 c.49_51delTTGinsCA frameshift_variant&missense_variant 0.15 bedaquiline
rifampicin
fbiB 3642668 c.1134A>G synonymous_variant 0.15 clofazimine
pretomanid
delamanid
rpoA 3877494 p.Glu338Asp missense_variant 0.14 rifampicin Uncertain significance
rpoA 3877503 c.1005G>C synonymous_variant 0.16 rifampicin
rpoA 3877507 p.Gly334Ala missense_variant 0.17 rifampicin
rpoA 3877515 c.993G>C synonymous_variant 0.2 rifampicin
rpoA 3877553 p.Glu319Gln missense_variant 0.26 rifampicin
rpoA 3877571 p.Pro313Ala missense_variant 0.23 rifampicin
rpoA 3877587 c.921A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3877679 p.Ala277Ser missense_variant 0.13 rifampicin
rpoA 3877743 c.765T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoA 3877770 c.738A>G synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoA 3877962 c.546G>T synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoA 3878284 p.Glu75Ala missense_variant 0.17 rifampicin
rpoA 3878292 c.216T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3878298 c.210A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3878304 c.204G>C synonymous_variant 0.19 rifampicin
rpoA 3878313 c.195G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoA 3878322 c.186A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3878415 c.93C>T synonymous_variant 0.2 rifampicin
rpoA 3878424 c.84G>C synonymous_variant 0.21 rifampicin
rpoA 3878436 c.72A>G synonymous_variant 0.23 rifampicin
rpoA 3878442 c.66G>C synonymous_variant 0.17 rifampicin
rpoA 3878853 c.-346G>A upstream_gene_variant 0.2 rifampicin
rpoA 3878860 c.-353C>T upstream_gene_variant 0.2 rifampicin
rpoA 3878878 c.-371T>C upstream_gene_variant 0.2 rifampicin Uncertain significance
rpoA 3878909 c.-402A>G upstream_gene_variant 0.18 rifampicin
rpoA 3878914 c.-407T>C upstream_gene_variant 0.16 rifampicin Uncertain significance
rpoA 3878917 c.-410G>A upstream_gene_variant 0.17 rifampicin Uncertain significance
rpoA 3878938 c.-431T>A upstream_gene_variant 0.27 rifampicin
rpoA 3878947 c.-440G>C upstream_gene_variant 0.25 rifampicin Uncertain significance
rpoA 3878962 c.-455G>A upstream_gene_variant 0.22 rifampicin Uncertain significance
rpoA 3878968 c.-461T>C upstream_gene_variant 0.2 rifampicin Uncertain significance
rpoA 3878976 c.-469A>G upstream_gene_variant 0.16 rifampicin Uncertain significance
rpoA 3878986 c.-479G>C upstream_gene_variant 0.17 rifampicin
rpoA 3878998 c.-491C>G upstream_gene_variant 0.18 rifampicin Uncertain significance
rpoA 3879005 c.-499_-498delAAinsCG upstream_gene_variant 0.19 rifampicin
rpoA 3879013 c.-506A>G upstream_gene_variant 0.25 rifampicin
rpoA 3879079 c.-572A>G upstream_gene_variant 0.2 rifampicin
rpoA 3879088 c.-581A>C upstream_gene_variant 0.2 rifampicin
rpoA 3879094 c.-587T>C upstream_gene_variant 0.2 rifampicin
rpoA 3879121 c.-614T>G upstream_gene_variant 0.18 rifampicin
rpoA 3879127 c.-620T>C upstream_gene_variant 0.15 rifampicin
rpoA 3879154 c.-647T>C upstream_gene_variant 0.16 rifampicin
clpC1 4038278 c.2427T>C synonymous_variant 0.17 pyrazinamide
clpC1 4038293 c.2412G>C synonymous_variant 0.21 pyrazinamide
clpC1 4038302 c.2403C>G synonymous_variant 0.26 pyrazinamide
clpC1 4038308 c.2397G>T synonymous_variant 0.22 pyrazinamide
clpC1 4038314 c.2391T>C synonymous_variant 0.22 pyrazinamide
clpC1 4038317 c.2388G>C synonymous_variant 0.21 pyrazinamide
clpC1 4038320 c.2385G>T synonymous_variant 0.21 pyrazinamide
clpC1 4038356 c.2349T>C synonymous_variant 0.27 pyrazinamide
clpC1 4038359 c.2346A>G synonymous_variant 0.27 pyrazinamide
clpC1 4038368 c.2337T>C synonymous_variant 0.24 pyrazinamide
clpC1 4038388 c.2317T>C synonymous_variant 0.22 pyrazinamide
clpC1 4038392 c.2313C>T synonymous_variant 0.21 pyrazinamide
clpC1 4038398 c.2307G>T synonymous_variant 0.2 pyrazinamide
clpC1 4038403 c.2302T>C synonymous_variant 0.18 pyrazinamide Not assoc w R - Interim
clpC1 4038407 c.2298G>C synonymous_variant 0.17 pyrazinamide
clpC1 4038419 c.2286T>C synonymous_variant 0.17 pyrazinamide
clpC1 4038530 p.Glu725Asp missense_variant 0.15 pyrazinamide
clpC1 4038596 c.2109A>G synonymous_variant 0.26 pyrazinamide
clpC1 4038623 c.2082A>G synonymous_variant 0.21 pyrazinamide
clpC1 4038640 p.Asp689Asn missense_variant 0.25 pyrazinamide
clpC1 4038653 c.2052C>T synonymous_variant 0.23 pyrazinamide
clpC1 4038658 p.Lys683Gln missense_variant 0.19 pyrazinamide
clpC1 4038661 p.Ser682Thr missense_variant 0.19 pyrazinamide
clpC1 4038662 c.2043T>C synonymous_variant 0.19 pyrazinamide
clpC1 4038671 c.2034T>C synonymous_variant 0.22 pyrazinamide
clpC1 4038683 c.2022T>C synonymous_variant 0.21 pyrazinamide Not assoc w R - Interim
clpC1 4038695 c.2010C>G synonymous_variant 0.17 pyrazinamide
clpC1 4038755 c.1950G>T synonymous_variant 0.13 pyrazinamide
clpC1 4038812 c.1893T>C synonymous_variant 0.24 pyrazinamide
clpC1 4038845 c.1860G>C synonymous_variant 0.29 pyrazinamide
clpC1 4038860 c.1845G>C synonymous_variant 0.33 pyrazinamide Not assoc w R - Interim
clpC1 4038878 c.1827A>G synonymous_variant 0.37 pyrazinamide Not assoc w R - Interim
clpC1 4038893 c.1812C>T synonymous_variant 0.38 pyrazinamide
clpC1 4038908 c.1797C>G synonymous_variant 0.33 pyrazinamide
clpC1 4038914 c.1791G>C synonymous_variant 0.31 pyrazinamide
clpC1 4038923 c.1780_1782delCTAinsTG frameshift_variant&synonymous_variant 0.3 pyrazinamide
clpC1 4038953 c.1752A>G synonymous_variant 0.3 pyrazinamide
clpC1 4038956 c.1749T>C synonymous_variant 0.31 pyrazinamide
clpC1 4038965 c.1740T>C synonymous_variant 0.3 pyrazinamide
clpC1 4038971 c.1734T>C synonymous_variant 0.3 pyrazinamide
clpC1 4038974 c.1731T>C synonymous_variant 0.27 pyrazinamide Not assoc w R - Interim
clpC1 4038989 c.1716T>C synonymous_variant 0.19 pyrazinamide
clpC1 4038997 c.1708T>C synonymous_variant 0.25 pyrazinamide Not assoc w R - Interim
clpC1 4039004 c.1701C>G synonymous_variant 0.27 pyrazinamide
clpC1 4039022 c.1683A>G synonymous_variant 0.2 pyrazinamide
clpC1 4039064 c.1641C>T synonymous_variant 0.17 pyrazinamide
clpC1 4039121 c.1584T>C synonymous_variant 0.15 pyrazinamide
clpC1 4039183 c.1522T>C synonymous_variant 0.14 pyrazinamide
clpC1 4039186 c.1519C>T synonymous_variant 0.14 pyrazinamide
clpC1 4039226 c.1479T>C synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
clpC1 4039229 c.1476C>G synonymous_variant 0.2 pyrazinamide
clpC1 4039274 c.1431G>C synonymous_variant 0.15 pyrazinamide Not assoc w R - Interim
clpC1 4039286 c.1419T>C synonymous_variant 0.16 pyrazinamide
clpC1 4039295 c.1410A>C synonymous_variant 0.16 pyrazinamide
clpC1 4039298 c.1407T>C synonymous_variant 0.14 pyrazinamide
clpC1 4039391 c.1314T>G synonymous_variant 0.14 pyrazinamide
clpC1 4039442 c.1263A>G synonymous_variant 0.14 pyrazinamide
clpC1 4039454 c.1251A>G synonymous_variant 0.18 pyrazinamide Not assoc w R - Interim
clpC1 4039463 c.1242C>G synonymous_variant 0.17 pyrazinamide
clpC1 4039694 c.1011G>C synonymous_variant 0.14 pyrazinamide
clpC1 4039982 c.723G>A synonymous_variant 0.13 pyrazinamide Not assoc w R - Interim
clpC1 4040033 c.672G>C synonymous_variant 0.15 pyrazinamide
clpC1 4040036 c.669C>G synonymous_variant 0.14 pyrazinamide
clpC1 4040090 c.613_615delTCTinsAGC synonymous_variant 0.24 pyrazinamide
clpC1 4040093 c.612C>G synonymous_variant 0.24 pyrazinamide Not assoc w R - Interim
clpC1 4040105 c.600C>G synonymous_variant 0.29 pyrazinamide
clpC1 4040147 c.558A>G synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
clpC1 4040162 c.543G>C synonymous_variant 0.15 pyrazinamide Not assoc w R - Interim
clpC1 4040201 c.504C>G synonymous_variant 0.17 pyrazinamide
clpC1 4040225 c.480A>C synonymous_variant 0.15 pyrazinamide
clpC1 4040228 c.477G>T synonymous_variant 0.21 pyrazinamide
clpC1 4040237 c.468C>T synonymous_variant 0.21 pyrazinamide
clpC1 4040246 c.459C>G synonymous_variant 0.29 pyrazinamide
clpC1 4040249 c.456A>G synonymous_variant 0.33 pyrazinamide
clpC1 4040267 c.438A>G synonymous_variant 0.3 pyrazinamide Not assoc w R - Interim
clpC1 4040273 c.432T>C synonymous_variant 0.32 pyrazinamide Not assoc w R - Interim
clpC1 4040276 c.427_429delTCCinsAGT synonymous_variant 0.27 pyrazinamide
clpC1 4040279 c.426C>G synonymous_variant 0.26 pyrazinamide Not assoc w R - Interim
clpC1 4040291 c.414G>C synonymous_variant 0.23 pyrazinamide
clpC1 4040318 c.387C>G synonymous_variant 0.2 pyrazinamide
clpC1 4040330 c.375C>G synonymous_variant 0.17 pyrazinamide
clpC1 4040477 c.228G>C synonymous_variant 0.14 pyrazinamide
clpC1 4040480 c.225T>G synonymous_variant 0.17 pyrazinamide
clpC1 4040522 c.183T>C synonymous_variant 0.15 pyrazinamide Not assoc w R - Interim
glpK 4138670 c.1086G>C synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138679 c.1075_1077delATGinsGC frameshift_variant&missense_variant 0.19 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
glpK 4138695 p.Pro354Asp missense_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138718 c.1038T>C synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138721 c.1035G>A synonymous_variant 0.24 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4138724 c.1032A>G synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138730 c.1026C>G synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138736 c.1020C>A synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138757 c.999A>G synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138763 c.993G>A synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
embC 4240726 c.864G>C synonymous_variant 0.13 ethambutol Not assoc w R - Interim
embC 4240780 c.918T>C synonymous_variant 0.16 ethambutol
embC 4240783 c.921G>C synonymous_variant 0.16 ethambutol
embC 4240789 c.927T>C synonymous_variant 0.16 ethambutol
embC 4241053 c.1191G>C synonymous_variant 0.15 ethambutol
embC 4241089 c.1227C>G synonymous_variant 0.23 ethambutol
embC 4241095 c.1233C>T synonymous_variant 0.24 ethambutol
embC 4241107 c.1245G>C synonymous_variant 0.22 ethambutol
embC 4241140 c.1278A>G synonymous_variant 0.17 ethambutol Not assoc w R - Interim
embC 4241738 p.Val626Leu missense_variant 0.95 ethambutol
embC 4242643 c.2781C>T synonymous_variant 0.98 ethambutol Not assoc w R
embA 4243460 c.228C>T synonymous_variant 1.0 ethambutol Not assoc w R
embA 4245137 c.1905T>C synonymous_variant 0.21 ethambutol
embA 4245146 c.1914G>A synonymous_variant 0.2 ethambutol
embA 4245149 c.1917C>G synonymous_variant 0.17 ethambutol
embA 4245153 p.Ile641Val missense_variant 0.17 ethambutol
embA 4245182 c.1950T>C synonymous_variant 0.25 ethambutol
embA 4245189 c.1957C>T synonymous_variant 0.25 ethambutol
embA 4245198 p.Leu656Ile missense_variant 0.22 ethambutol
embA 4245207 c.1975T>C synonymous_variant 0.19 ethambutol
embA 4245215 c.1983A>C synonymous_variant 0.2 ethambutol
embA 4245222 c.1990_1992delTATinsCG frameshift_variant&missense_variant 0.21 ethambutol Uncertain significance
embA 4245248 c.2016G>C synonymous_variant 0.15 ethambutol
embB 4245704 c.-810G>C upstream_gene_variant 0.15 ethambutol
embB 4245725 c.-789A>G upstream_gene_variant 0.16 ethambutol
embB 4245726 c.-788T>C upstream_gene_variant 0.16 ethambutol
embB 4245737 c.-777A>C upstream_gene_variant 0.15 ethambutol
embB 4245740 c.-774T>C upstream_gene_variant 0.17 ethambutol
embB 4247539 c.1026T>C synonymous_variant 0.15 ethambutol
embB 4247830 c.1317A>G synonymous_variant 0.18 ethambutol Not assoc w R - Interim
embB 4247836 c.1323A>G synonymous_variant 0.19 ethambutol Not assoc w R - Interim
embB 4247839 c.1326G>C synonymous_variant 0.19 ethambutol Not assoc w R - Interim
embB 4247866 c.1353G>C synonymous_variant 0.16 ethambutol
embB 4247899 p.Met462Ile missense_variant 0.21 ethambutol
embB 4247905 c.1392G>C synonymous_variant 0.19 ethambutol Not assoc w R - Interim
embB 4247909 c.1396T>C synonymous_variant 0.21 ethambutol
embB 4247914 c.1401G>C synonymous_variant 0.23 ethambutol Not assoc w R - Interim
embB 4247932 c.1419C>G synonymous_variant 0.23 ethambutol
embB 4247940 p.Leu476Trp missense_variant 0.24 ethambutol
embB 4247945 c.1432T>C synonymous_variant 0.24 ethambutol
embB 4247951 p.Ser480Ala missense_variant 0.22 ethambutol
embB 4247956 c.1443G>C synonymous_variant 0.21 ethambutol Not assoc w R - Interim
embB 4247974 c.1461C>G synonymous_variant 0.2 ethambutol
embB 4248007 c.1494C>G synonymous_variant 0.16 ethambutol
embB 4248011 p.Ser500Arg missense_variant 0.16 ethambutol
embB 4248014 p.Thr501Ala missense_variant 0.15 ethambutol Uncertain significance
embB 4248035 p.Val508Ile missense_variant 0.17 ethambutol
embB 4248040 c.1527C>G synonymous_variant 0.15 ethambutol
embB 4248041 p.Ala510Thr missense_variant 0.14 ethambutol Uncertain significance
embB 4248044 c.1531_1533delAAAinsGG frameshift_variant&missense_variant 0.14 ethambutol
embB 4248070 c.1557T>C synonymous_variant 0.19 ethambutol
embB 4248085 c.1572T>C synonymous_variant 0.18 ethambutol
embB 4248097 c.1584C>G synonymous_variant 0.2 ethambutol
embB 4248130 c.1617G>C synonymous_variant 0.18 ethambutol
embB 4248142 c.1629T>C synonymous_variant 0.21 ethambutol
embB 4248143 c.1630T>C synonymous_variant 0.2 ethambutol
embB 4248157 c.1644A>G synonymous_variant 0.21 ethambutol Not assoc w R - Interim
embB 4248172 c.1659G>C synonymous_variant 0.19 ethambutol
embB 4248220 c.1707A>C synonymous_variant 0.16 ethambutol
embB 4248304 c.1791G>C synonymous_variant 0.25 ethambutol
embB 4248316 c.1803C>G synonymous_variant 0.25 ethambutol
embB 4248319 c.1806A>G synonymous_variant 0.25 ethambutol
embB 4248343 c.1830G>C synonymous_variant 0.19 ethambutol
embB 4248350 c.1837T>C synonymous_variant 0.19 ethambutol
embB 4249417 c.2904A>G synonymous_variant 0.21 ethambutol
embB 4249423 p.Asp970Glu missense_variant 0.21 ethambutol Uncertain significance
embB 4249424 p.Leu971Met missense_variant 0.21 ethambutol
embB 4249429 c.2916C>T synonymous_variant 0.18 ethambutol
embB 4249432 c.2919A>G synonymous_variant 0.2 ethambutol
embB 4249441 c.2928A>G synonymous_variant 0.21 ethambutol Not assoc w R - Interim
embB 4249444 c.2931T>C synonymous_variant 0.21 ethambutol
aftB 4267647 p.Asp397Gly missense_variant 0.98 ethambutol Not assoc w R
aftB 4268164 p.Gln225Glu missense_variant 0.15 ethambutol
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 capreomycin
amikacin
kanamycin
gid 4407588 c.615A>G synonymous_variant 1.0 streptomycin Not assoc w R
gid 4407927 p.Glu92Asp missense_variant 1.0 streptomycin Not assoc w R