TB-Profiler result

Run: SRR6832644
Summary

Run ID: SRR6832644

Sample name:

Date: 2024-04-16T08:45:08.262215

Number of reads: 359064

Percentage reads mapped: 14.69

Median coverage: 6.0

Strain: lineage4.3.3;lineage4.9

Spoligotype:

Drug-resistance: Other

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage4.3 Euro-American (LAM) None 0.18
lineage4 Euro-American None 1.0
lineage4.9 Euro-American (H37Rv-like) None 0.8
lineage4.3.3 Euro-American (LAM) RD115 1.0
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol
pyrazinamide
streptomycin rrs n.799C>T Uncertain significance Mutation from literature
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
rrs 1472644 n.799C>T non_coding_transcript_exon_variant 0.87 streptomycin Uncertain significance Mutation from literature
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
rpoB 762143 c.2337T>C synonymous_variant 0.72 rifampicin
rpoB 762149 c.2343G>C synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoB 762156 c.2350_2352delGTGinsAC frameshift_variant&missense_variant 0.75 rifampicin
rpoB 762173 p.Glu789Asp missense_variant 0.71 rifampicin
rpoB 762176 c.2370T>C synonymous_variant 0.74 rifampicin Not assoc w R - Interim
rpoB 762181 p.Asp792Ala missense_variant 0.75 rifampicin
rpoB 762185 c.2379G>C synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoB 762191 c.2385C>T synonymous_variant 0.78 rifampicin
rpoB 762197 c.2391C>G synonymous_variant 0.8 rifampicin
rpoB 762200 c.2394C>T synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoB 762233 c.2427G>C synonymous_variant 0.87 rifampicin Not assoc w R - Interim
rpoB 762242 c.2436G>A synonymous_variant 0.78 rifampicin
rpoB 762245 c.2439G>C synonymous_variant 0.78 rifampicin Not assoc w R - Interim
rpoB 762254 c.2448T>C synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoB 762257 c.2451C>G synonymous_variant 0.77 rifampicin
rpoB 762266 c.2460T>C synonymous_variant 0.75 rifampicin
rpoB 762284 c.2478G>T synonymous_variant 0.77 rifampicin
rpoB 762290 c.2484C>T synonymous_variant 0.7 rifampicin
rpoB 762293 c.2487T>C synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoB 762296 c.2490G>C synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoB 762297 p.Leu831Met missense_variant 0.6 rifampicin
rpoC 762989 c.-381G>C upstream_gene_variant 0.67 rifampicin
rpoB 762995 c.3189G>C synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoB 763005 p.Cys1067Val missense_variant 0.69 rifampicin
rpoC 763013 c.-357C>A upstream_gene_variant 0.7 rifampicin
rpoC 763022 c.-348C>A upstream_gene_variant 0.76 rifampicin
rpoB 763028 c.3222T>C synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoB 763053 c.3247T>C synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoC 763594 c.225C>T synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoC 763603 c.234C>T synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoC 763609 c.240C>T synonymous_variant 0.77 rifampicin
rpoC 763619 p.Arg84Lys missense_variant 0.77 rifampicin
rpoC 763622 p.Ala85Ser missense_variant 0.77 rifampicin Uncertain significance
rpoC 763630 c.261G>T synonymous_variant 0.76 rifampicin
rpoC 763633 c.264T>C synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoC 763642 c.273G>C synonymous_variant 0.81 rifampicin Not assoc w R - Interim
rpoC 763654 c.285C>T synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoC 763660 c.291T>G synonymous_variant 0.84 rifampicin Not assoc w R - Interim
rpoC 763666 c.297G>T synonymous_variant 0.84 rifampicin
rpoC 763669 c.300C>G synonymous_variant 0.81 rifampicin Not assoc w R - Interim
rpoC 763672 c.303C>A synonymous_variant 0.81 rifampicin
rpoC 763696 c.327T>C synonymous_variant 0.74 rifampicin Not assoc w R - Interim
rpoC 763699 c.330G>T synonymous_variant 0.74 rifampicin
rpoC 763702 c.333C>T synonymous_variant 0.74 rifampicin Not assoc w R - Interim
rpoC 763705 c.336G>C synonymous_variant 0.74 rifampicin
rpoC 763708 c.339G>C synonymous_variant 0.74 rifampicin
rpoC 763714 c.345G>C synonymous_variant 0.74 rifampicin Not assoc w R - Interim
rpoC 763717 c.348T>C synonymous_variant 0.74 rifampicin Not assoc w R - Interim
rpoC 763732 c.363C>T synonymous_variant 0.73 rifampicin
rpoC 764311 c.942C>G synonymous_variant 0.81 rifampicin
rpoC 764314 c.945C>T synonymous_variant 0.81 rifampicin
rpoC 764318 p.Val317Ile missense_variant 0.84 rifampicin
rpoC 764326 c.957G>T synonymous_variant 0.85 rifampicin
rpoC 764329 c.960C>T synonymous_variant 0.85 rifampicin Not assoc w R - Interim
rpoC 764335 c.966G>A synonymous_variant 0.84 rifampicin Not assoc w R - Interim
rpoC 764359 c.990C>G synonymous_variant 0.84 rifampicin
rpoC 764365 c.996C>T synonymous_variant 0.84 rifampicin Not assoc w R - Interim
rpoC 764371 c.1002G>C synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoC 764374 c.1005C>T synonymous_variant 0.83 rifampicin
rpoC 764377 c.1008C>T synonymous_variant 0.83 rifampicin
rpoC 764380 c.1011G>C synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoC 764387 c.1018T>C synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoC 764398 c.1029G>C synonymous_variant 0.77 rifampicin
rpoC 764405 c.1036_1038delAGGinsCC frameshift_variant&missense_variant 0.7 rifampicin
rpoC 764410 c.1041G>T synonymous_variant 0.64 rifampicin
rpoC 764548 c.1179G>T synonymous_variant 0.89 rifampicin Not assoc w R - Interim
rpoC 764566 c.1197C>G synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoC 764572 c.1203G>C synonymous_variant 0.94 rifampicin
rpoC 764575 c.1206T>G synonymous_variant 0.91 rifampicin Not assoc w R - Interim
rpoC 764578 c.1209C>T synonymous_variant 0.91 rifampicin
rpoC 764581 c.1212T>C synonymous_variant 0.91 rifampicin
rpoC 764582 c.1213C>T synonymous_variant 0.91 rifampicin
rpoC 764605 c.1236G>C synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoC 764611 c.1242G>C synonymous_variant 0.93 rifampicin
rpoC 764623 c.1254C>G synonymous_variant 0.85 rifampicin Not assoc w R - Interim
rpoC 764626 c.1257C>T synonymous_variant 0.85 rifampicin Not assoc w R - Interim
rpoC 764632 c.1263T>C synonymous_variant 0.85 rifampicin Not assoc w R - Interim
rpoC 764635 c.1266C>G synonymous_variant 0.85 rifampicin
rpoC 764644 c.1275G>T synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoC 764863 c.1494G>C synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoC 764869 c.1500C>T synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoC 764875 c.1506C>T synonymous_variant 0.85 rifampicin
rpoC 764878 c.1509C>G synonymous_variant 0.85 rifampicin
rpoC 764887 c.1518G>C synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoC 764888 c.1519T>C synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoC 764911 c.1542A>G synonymous_variant 0.92 rifampicin
rpoC 764913 p.Met515Lys missense_variant 0.92 rifampicin
rpoC 764920 c.1551G>T synonymous_variant 0.95 rifampicin
rpoC 764923 c.1554A>G synonymous_variant 0.95 rifampicin Not assoc w R - Interim
rpoC 764926 c.1557C>T synonymous_variant 0.95 rifampicin
rpoC 764932 c.1563C>T synonymous_variant 0.95 rifampicin Not assoc w R - Interim
rpoC 764948 c.1579T>C synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoC 764952 p.Val528Ala missense_variant 0.94 rifampicin
rpoC 764968 c.1599T>C synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rplC 800693 c.-116A>T upstream_gene_variant 0.59 linezolid
rplC 800702 c.-107G>C upstream_gene_variant 0.56 linezolid
rplC 800703 c.-106T>C upstream_gene_variant 0.56 linezolid
rplC 800714 c.-95C>T upstream_gene_variant 0.53 linezolid
rplC 800715 c.-94A>C upstream_gene_variant 0.53 linezolid
rplC 800720 c.-89T>C upstream_gene_variant 0.53 linezolid
rplC 800723 c.-86C>A upstream_gene_variant 0.53 linezolid
rplC 800726 c.-83G>C upstream_gene_variant 0.53 linezolid
rplC 800741 c.-68C>T upstream_gene_variant 0.62 linezolid
rplC 800744 c.-65G>T upstream_gene_variant 0.56 linezolid
rplC 800747 c.-62C>T upstream_gene_variant 0.56 linezolid
rrs 1471922 n.78delT non_coding_transcript_exon_variant 0.75 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471922 n.78T>C non_coding_transcript_exon_variant 0.23 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471922 n.78delT non_coding_transcript_exon_variant 0.75 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471922 n.78T>C non_coding_transcript_exon_variant 0.23 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471925 n.80_81insTG non_coding_transcript_exon_variant 0.23 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471925 n.80T>C non_coding_transcript_exon_variant 0.74 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471925 n.80_81insTG non_coding_transcript_exon_variant 0.23 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471925 n.80T>C non_coding_transcript_exon_variant 0.74 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471928 n.83T>G non_coding_transcript_exon_variant 0.73 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471929 n.84_89delCGGAGAinsGCAGGG non_coding_transcript_exon_variant 0.23 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472069 n.224G>A non_coding_transcript_exon_variant 0.86 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472078 n.233C>T non_coding_transcript_exon_variant 0.97 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472106 n.261G>A non_coding_transcript_exon_variant 0.98 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.98 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472123 n.278A>G non_coding_transcript_exon_variant 0.97 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472150 n.305T>G non_coding_transcript_exon_variant 0.98 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472151 n.306C>A non_coding_transcript_exon_variant 0.98 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472160 n.315C>T non_coding_transcript_exon_variant 0.98 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472344 n.499C>T non_coding_transcript_exon_variant 0.7 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472412 n.567A>G non_coding_transcript_exon_variant 0.61 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472471 n.626G>A non_coding_transcript_exon_variant 0.56 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472485 n.640delGinsTA non_coding_transcript_exon_variant 0.63 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472489 n.644A>T non_coding_transcript_exon_variant 0.69 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472498 n.653C>T non_coding_transcript_exon_variant 0.9 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472504 n.659A>T non_coding_transcript_exon_variant 0.91 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472505 n.660G>A non_coding_transcript_exon_variant 0.91 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472530 n.685G>A non_coding_transcript_exon_variant 0.94 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472558 n.713G>A non_coding_transcript_exon_variant 0.96 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472569 n.724G>A non_coding_transcript_exon_variant 0.95 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472573 n.728C>T non_coding_transcript_exon_variant 0.95 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472574 n.729T>A non_coding_transcript_exon_variant 0.95 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472584 n.739A>T non_coding_transcript_exon_variant 0.95 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472607 n.762G>A non_coding_transcript_exon_variant 0.95 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472612 n.767G>T non_coding_transcript_exon_variant 0.93 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472660 n.815T>C non_coding_transcript_exon_variant 0.7 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472661 n.816A>G non_coding_transcript_exon_variant 0.7 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472671 n.826G>A non_coding_transcript_exon_variant 0.53 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472713 n.868T>C non_coding_transcript_exon_variant 0.9 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472714 n.869A>G non_coding_transcript_exon_variant 0.9 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472828 n.983T>C non_coding_transcript_exon_variant 0.86 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472836 n.991G>A non_coding_transcript_exon_variant 0.76 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472895 n.1050C>T non_coding_transcript_exon_variant 0.56 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472957 n.1112C>T non_coding_transcript_exon_variant 0.93 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472970 n.1125_1128delCGTAinsT non_coding_transcript_exon_variant 0.92 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472974 n.1129A>T non_coding_transcript_exon_variant 0.92 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472977 n.1133dupT non_coding_transcript_exon_variant 0.93 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472987 n.1142G>A non_coding_transcript_exon_variant 0.95 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473035 n.1190G>A non_coding_transcript_exon_variant 0.9 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1473080 n.1235C>T non_coding_transcript_exon_variant 0.75 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473132 n.1287T>C non_coding_transcript_exon_variant 0.73 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473135 n.1290C>T non_coding_transcript_exon_variant 0.83 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.88 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.91 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473202 n.1357C>T non_coding_transcript_exon_variant 0.95 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473259 n.1414C>T non_coding_transcript_exon_variant 0.97 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1473276 n.1431A>G non_coding_transcript_exon_variant 0.96 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473283 n.1438T>C non_coding_transcript_exon_variant 0.95 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473286 n.1441_1445delCCCTCinsACTT non_coding_transcript_exon_variant 0.95 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473292 n.1447G>T non_coding_transcript_exon_variant 0.92 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473293 n.1448G>T non_coding_transcript_exon_variant 0.92 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473301 n.1456T>C non_coding_transcript_exon_variant 0.92 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473346 n.1501G>C non_coding_transcript_exon_variant 0.8 streptomycin
kanamycin
capreomycin
amikacin
rrl 1473697 n.40C>G non_coding_transcript_exon_variant 0.83 capreomycin
linezolid
rrl 1473698 n.41G>C non_coding_transcript_exon_variant 0.83 capreomycin
linezolid
rrl 1473699 n.42A>T non_coding_transcript_exon_variant 0.83 capreomycin
linezolid
rrl 1473718 n.61G>A non_coding_transcript_exon_variant 0.81 capreomycin
linezolid
rrl 1473719 n.62G>A non_coding_transcript_exon_variant 0.81 capreomycin
linezolid
rrl 1473728 n.71A>T non_coding_transcript_exon_variant 0.81 capreomycin
linezolid
rrl 1473731 n.74T>A non_coding_transcript_exon_variant 0.81 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473743 n.86C>T non_coding_transcript_exon_variant 0.8 capreomycin
linezolid
rrl 1473750 n.93C>T non_coding_transcript_exon_variant 0.8 capreomycin
linezolid
rrl 1473751 n.94C>T non_coding_transcript_exon_variant 0.8 capreomycin
linezolid
rrl 1473752 n.95G>A non_coding_transcript_exon_variant 0.6 capreomycin
linezolid
rrl 1473758 n.101G>T non_coding_transcript_exon_variant 0.83 capreomycin Uncertain significance
linezolid
rrl 1473770 n.113T>G non_coding_transcript_exon_variant 0.85 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473911 n.254G>A non_coding_transcript_exon_variant 0.62 capreomycin
linezolid
rrl 1473918 n.261C>T non_coding_transcript_exon_variant 0.62 capreomycin
linezolid
rrl 1473922 n.265A>T non_coding_transcript_exon_variant 0.59 capreomycin
linezolid
rrl 1473923 n.266C>G non_coding_transcript_exon_variant 0.59 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474130 n.473C>T non_coding_transcript_exon_variant 0.78 capreomycin Uncertain significance
linezolid
rrl 1474140 n.483C>T non_coding_transcript_exon_variant 0.84 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474142 n.485C>T non_coding_transcript_exon_variant 0.86 capreomycin
linezolid
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.86 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474182 n.525C>A non_coding_transcript_exon_variant 0.91 capreomycin
linezolid
rrl 1474183 n.526T>G non_coding_transcript_exon_variant 0.91 capreomycin
linezolid
rrl 1474184 n.527C>T non_coding_transcript_exon_variant 0.91 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474185 n.529delA non_coding_transcript_exon_variant 0.91 capreomycin
linezolid
rrl 1474197 n.540C>T non_coding_transcript_exon_variant 0.94 capreomycin Uncertain significance
linezolid
rrl 1474199 n.542G>T non_coding_transcript_exon_variant 0.94 capreomycin
linezolid
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 0.95 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474253 n.596A>T non_coding_transcript_exon_variant 0.92 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474263 n.606G>A non_coding_transcript_exon_variant 0.91 capreomycin Uncertain significance
linezolid
rrl 1474269 n.612C>T non_coding_transcript_exon_variant 0.86 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474286 n.629_630delCTinsA non_coding_transcript_exon_variant 0.79 capreomycin
linezolid
rrl 1474293 n.637_651delCCTCTCCGGAGGAGG non_coding_transcript_exon_variant 0.74 capreomycin
linezolid
rrl 1474311 n.654_655insT non_coding_transcript_exon_variant 0.7 capreomycin
linezolid
rrl 1474467 n.810A>G non_coding_transcript_exon_variant 0.56 capreomycin
linezolid
rrl 1474487 n.830G>T non_coding_transcript_exon_variant 0.6 capreomycin
linezolid
rrl 1474495 n.838G>A non_coding_transcript_exon_variant 0.58 capreomycin
linezolid
rrl 1474496 n.839C>G non_coding_transcript_exon_variant 0.58 capreomycin Uncertain significance
linezolid
rrl 1474497 n.840G>C non_coding_transcript_exon_variant 0.58 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474498 n.841G>T non_coding_transcript_exon_variant 0.58 capreomycin
linezolid
rrl 1474505 n.848C>G non_coding_transcript_exon_variant 0.6 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474506 n.849C>G non_coding_transcript_exon_variant 0.62 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474507 n.850G>T non_coding_transcript_exon_variant 0.65 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474508 n.851C>T non_coding_transcript_exon_variant 0.64 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474517 n.860C>G non_coding_transcript_exon_variant 0.76 capreomycin
linezolid
rrl 1474527 n.870T>G non_coding_transcript_exon_variant 0.84 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474537 n.880G>A non_coding_transcript_exon_variant 0.91 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474542 n.885A>C non_coding_transcript_exon_variant 0.89 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474734 n.1077G>T non_coding_transcript_exon_variant 0.81 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474736 n.1079C>T non_coding_transcript_exon_variant 0.81 capreomycin
linezolid
rrl 1474749 n.1092C>T non_coding_transcript_exon_variant 0.76 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474751 n.1094G>A non_coding_transcript_exon_variant 0.72 capreomycin
linezolid
rrl 1474753 n.1097delC non_coding_transcript_exon_variant 0.72 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474760 n.1103A>G non_coding_transcript_exon_variant 0.87 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474784 n.1127C>T non_coding_transcript_exon_variant 0.95 capreomycin
linezolid
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.97 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474798 n.1141C>G non_coding_transcript_exon_variant 0.98 capreomycin
linezolid
rrl 1474803 n.1146G>A non_coding_transcript_exon_variant 0.98 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.99 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474823 n.1166C>G non_coding_transcript_exon_variant 0.99 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474824 n.1167A>G non_coding_transcript_exon_variant 0.99 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474825 n.1168G>A non_coding_transcript_exon_variant 0.99 capreomycin
linezolid
rrl 1474830 n.1173A>G non_coding_transcript_exon_variant 0.99 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474837 n.1180A>G non_coding_transcript_exon_variant 0.98 capreomycin
linezolid
rrl 1474864 n.1207C>T non_coding_transcript_exon_variant 0.99 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1474896 n.1239A>G non_coding_transcript_exon_variant 0.98 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474901 n.1244A>G non_coding_transcript_exon_variant 0.96 capreomycin
linezolid
rrl 1474904 n.1247G>C non_coding_transcript_exon_variant 0.95 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474913 n.1256T>C non_coding_transcript_exon_variant 0.94 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474917 n.1260G>T non_coding_transcript_exon_variant 0.94 capreomycin
linezolid
rrl 1474918 n.1261T>C non_coding_transcript_exon_variant 0.65 capreomycin
linezolid
rrl 1474921 n.1264C>T non_coding_transcript_exon_variant 0.94 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474932 n.1275C>T non_coding_transcript_exon_variant 0.89 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475499 n.1842C>T non_coding_transcript_exon_variant 0.94 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475514 n.1857G>A non_coding_transcript_exon_variant 0.91 capreomycin Uncertain significance
linezolid
rrl 1475522 n.1865A>T non_coding_transcript_exon_variant 0.91 capreomycin
linezolid
rrl 1475525 n.1868G>A non_coding_transcript_exon_variant 0.91 capreomycin
linezolid
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.91 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475531 n.1874C>T non_coding_transcript_exon_variant 0.95 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475539 n.1882A>T non_coding_transcript_exon_variant 0.95 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475542 n.1885A>G non_coding_transcript_exon_variant 0.95 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475544 n.1887A>T non_coding_transcript_exon_variant 0.95 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475545 n.1888T>G non_coding_transcript_exon_variant 0.95 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475550 n.1893A>G non_coding_transcript_exon_variant 0.95 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475562 n.1905C>T non_coding_transcript_exon_variant 0.96 capreomycin
linezolid
rrl 1475713 n.2056C>T non_coding_transcript_exon_variant 0.82 capreomycin
linezolid
rrl 1475753 n.2096C>G non_coding_transcript_exon_variant 0.9 capreomycin Uncertain significance
linezolid
rrl 1475758 n.2101_2112delACCCGCAAGGGTinsGTAGTCTTTGACTGC non_coding_transcript_exon_variant 0.41 capreomycin
linezolid
rrl 1475758 n.2101_2112delACCCGCAAGGGTinsGTCAACTTTGTTGGC non_coding_transcript_exon_variant 0.5 capreomycin
linezolid
rrl 1475775 n.2118G>T non_coding_transcript_exon_variant 0.89 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475883 n.2226A>T non_coding_transcript_exon_variant 0.96 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475884 n.2227A>G non_coding_transcript_exon_variant 0.97 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475897 n.2240T>C non_coding_transcript_exon_variant 0.98 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475900 n.2243A>G non_coding_transcript_exon_variant 0.98 capreomycin Uncertain significance
linezolid
rrl 1475902 n.2245T>C non_coding_transcript_exon_variant 0.98 capreomycin Uncertain significance
linezolid
rrl 1475906 n.2249C>T non_coding_transcript_exon_variant 0.98 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475975 n.2318C>T non_coding_transcript_exon_variant 0.98 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475977 n.2320A>G non_coding_transcript_exon_variant 0.98 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.98 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1475993 n.2336C>T non_coding_transcript_exon_variant 0.97 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475997 n.2340A>T non_coding_transcript_exon_variant 0.97 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476030 n.2373A>G non_coding_transcript_exon_variant 0.95 capreomycin Uncertain significance
linezolid
rrl 1476032 n.2375C>T non_coding_transcript_exon_variant 0.51 capreomycin Uncertain significance
linezolid
rrl 1476033 n.2376T>A non_coding_transcript_exon_variant 0.51 capreomycin
linezolid
rrl 1476033 n.2376T>G non_coding_transcript_exon_variant 0.46 capreomycin
linezolid
rrl 1476034 n.2377C>T non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1476035 n.2378G>C non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1476040 n.2383C>T non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1476044 n.2387T>G non_coding_transcript_exon_variant 0.97 capreomycin Uncertain significance
linezolid
rrl 1476046 n.2389G>T non_coding_transcript_exon_variant 0.97 capreomycin
linezolid
rrl 1476049 n.2392C>T non_coding_transcript_exon_variant 0.98 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476080 n.2423T>G non_coding_transcript_exon_variant 0.98 capreomycin
linezolid
rrl 1476085 n.2428G>A non_coding_transcript_exon_variant 0.97 capreomycin Uncertain significance
linezolid
rrl 1476097 n.2440C>T non_coding_transcript_exon_variant 0.96 capreomycin
linezolid
rrl 1476099 n.2442A>G non_coding_transcript_exon_variant 0.96 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476100 n.2443A>C non_coding_transcript_exon_variant 0.96 capreomycin
linezolid
rrl 1476103 n.2446C>A non_coding_transcript_exon_variant 0.93 capreomycin Uncertain significance
linezolid
rrl 1476105 n.2450delA non_coding_transcript_exon_variant 0.93 capreomycin
linezolid
rrl 1476110 n.2453G>T non_coding_transcript_exon_variant 0.93 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476113 n.2456T>G non_coding_transcript_exon_variant 0.95 capreomycin
linezolid
rrl 1476116 n.2459A>G non_coding_transcript_exon_variant 0.96 capreomycin
linezolid
rrl 1476131 n.2474C>T non_coding_transcript_exon_variant 0.98 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476160 n.2503T>C non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476194 n.2537A>G non_coding_transcript_exon_variant 0.98 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476200 n.2543A>T non_coding_transcript_exon_variant 0.98 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476201 n.2544C>T non_coding_transcript_exon_variant 0.98 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476215 n.2558C>T non_coding_transcript_exon_variant 0.97 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.97 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476245 n.2588C>T non_coding_transcript_exon_variant 0.97 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476251 n.2594T>A non_coding_transcript_exon_variant 0.97 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476252 n.2595T>G non_coding_transcript_exon_variant 0.97 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476256 n.2599A>T non_coding_transcript_exon_variant 0.97 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476260 n.2603A>G non_coding_transcript_exon_variant 0.97 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.98 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476297 n.2640C>T non_coding_transcript_exon_variant 0.99 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476298 n.2641C>A non_coding_transcript_exon_variant 0.99 capreomycin
linezolid
rrl 1476300 n.2643G>T non_coding_transcript_exon_variant 0.99 capreomycin
linezolid
rrl 1476301 n.2644A>T non_coding_transcript_exon_variant 0.99 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476307 n.2650A>T non_coding_transcript_exon_variant 0.99 capreomycin
linezolid
rrl 1476309 n.2652G>T non_coding_transcript_exon_variant 0.99 capreomycin
linezolid
rrl 1476428 n.2771C>T non_coding_transcript_exon_variant 0.99 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476481 n.2824T>C non_coding_transcript_exon_variant 1.0 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476524 n.2867_2868delCAinsT non_coding_transcript_exon_variant 0.99 capreomycin
linezolid
rrl 1476535 n.2878G>A non_coding_transcript_exon_variant 0.98 capreomycin
linezolid
rrl 1476540 n.2883C>G non_coding_transcript_exon_variant 0.98 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476573 n.2916A>T non_coding_transcript_exon_variant 0.97 capreomycin Uncertain significance
linezolid
rrl 1476580 n.2923G>A non_coding_transcript_exon_variant 0.97 capreomycin
linezolid
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.96 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476585 n.2928A>G non_coding_transcript_exon_variant 0.96 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476592 n.2935G>A non_coding_transcript_exon_variant 0.97 capreomycin
linezolid
rrl 1476605 n.2948C>T non_coding_transcript_exon_variant 0.94 capreomycin
linezolid
rrl 1476607 n.2950C>T non_coding_transcript_exon_variant 0.96 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476614 n.2957A>T non_coding_transcript_exon_variant 0.95 capreomycin
linezolid
rrl 1476616 n.2959A>G non_coding_transcript_exon_variant 0.95 capreomycin
linezolid
rrl 1476619 n.2962C>T non_coding_transcript_exon_variant 0.93 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476624 n.2967T>A non_coding_transcript_exon_variant 0.93 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.93 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476629 n.2972C>A non_coding_transcript_exon_variant 0.93 capreomycin Uncertain significance
linezolid
rrl 1476630 n.2973A>G non_coding_transcript_exon_variant 0.93 capreomycin Uncertain significance
linezolid Uncertain significance
rpsA 1834195 c.654G>C synonymous_variant 0.73 pyrazinamide
rpsA 1834213 c.672G>C synonymous_variant 0.9 pyrazinamide
rpsA 1834234 c.693G>C synonymous_variant 0.86 pyrazinamide
rpsA 1834240 c.699T>C synonymous_variant 0.83 pyrazinamide
rpsA 1834246 c.705G>T synonymous_variant 0.86 pyrazinamide
rpsA 1834249 c.708T>C synonymous_variant 0.86 pyrazinamide
rpsA 1834252 c.711C>T synonymous_variant 0.86 pyrazinamide
rpsA 1834261 c.720A>G synonymous_variant 0.86 pyrazinamide Not assoc w R - Interim
rpsA 1834264 c.723G>T synonymous_variant 0.83 pyrazinamide
rpsA 1834276 c.735C>T synonymous_variant 0.78 pyrazinamide
rpsA 1834285 c.744G>A synonymous_variant 0.75 pyrazinamide Not assoc w R - Interim
rpsA 1834288 c.747C>T synonymous_variant 0.75 pyrazinamide
rpsA 1834294 c.753G>T synonymous_variant 0.62 pyrazinamide
clpC1 4039831 c.874T>C synonymous_variant 0.55 pyrazinamide
clpC1 4039838 c.865_867delCTGinsAC frameshift_variant&missense_variant 0.6 pyrazinamide
clpC1 4039844 c.861C>T synonymous_variant 0.55 pyrazinamide Not assoc w R - Interim
clpC1 4039850 c.855T>C synonymous_variant 0.55 pyrazinamide
clpC1 4039855 c.850C>T synonymous_variant 0.5 pyrazinamide
clpC1 4039865 c.840T>C synonymous_variant 0.46 pyrazinamide
clpC1 4039871 p.Thr278Gln missense_variant 0.46 pyrazinamide
clpC1 4039877 c.828C>T synonymous_variant 0.43 pyrazinamide
clpC1 4039898 c.807C>G synonymous_variant 0.43 pyrazinamide
clpC1 4039910 c.795C>T synonymous_variant 0.5 pyrazinamide
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 capreomycin
amikacin
kanamycin