TB-Profiler result

Run: SRR1173363
Summary

Run ID: SRR1173363

Sample name:

Date: 2024-10-04T05:45:37.322311

Number of reads: 374800

Percentage reads mapped: 46.38

Median coverage: 8.0

Strain:

Spoligotype:

Drug-resistance: Other

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage3.1.1 East-African-Indian RD750 0.32
La1.2.BCG M.bovis None 0.06
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol embB p.Met306Ile Assoc w R
pyrazinamide
streptomycin rrs n.462C>T Uncertain significance Mutation from literature
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
rrs 1472307 n.462C>T non_coding_transcript_exon_variant 0.77 streptomycin Uncertain significance Mutation from literature
embB 4247431 p.Met306Ile missense_variant 0.75 ethambutol Assoc w R
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
dnaA 705 c.705A>G synonymous_variant 0.33 isoniazid
dnaA 708 c.708T>C synonymous_variant 0.29 isoniazid
dnaA 741 c.741T>C synonymous_variant 0.29 isoniazid Not assoc w R - Interim
dnaA 750 c.750C>G synonymous_variant 0.33 isoniazid
dnaA 756 c.756T>C synonymous_variant 0.36 isoniazid
dnaA 768 c.768C>G synonymous_variant 0.38 isoniazid
dnaA 771 c.771A>C synonymous_variant 0.38 isoniazid
dnaA 777 c.777A>G synonymous_variant 0.39 isoniazid
dnaA 786 c.786C>T synonymous_variant 0.41 isoniazid
dnaA 792 c.792C>T synonymous_variant 0.35 isoniazid
dnaA 1068 c.1068T>C synonymous_variant 0.55 isoniazid
dnaA 1092 c.1092T>C synonymous_variant 0.7 isoniazid Not assoc w R - Interim
dnaA 1098 c.1098A>G synonymous_variant 0.7 isoniazid
dnaA 1137 c.1137C>G synonymous_variant 0.6 isoniazid
dnaA 1254 c.1254T>C synonymous_variant 0.41 isoniazid
dnaA 1278 c.1278T>C synonymous_variant 0.33 isoniazid
dnaA 1284 c.1284C>G synonymous_variant 0.35 isoniazid
dnaA 1290 c.1290G>A synonymous_variant 0.32 isoniazid
dnaA 1293 c.1293T>C synonymous_variant 0.29 isoniazid
dnaA 1299 c.1299G>C synonymous_variant 0.3 isoniazid Not assoc w R - Interim
dnaA 1302 c.1302C>G synonymous_variant 0.29 isoniazid
dnaA 1311 c.1311C>G synonymous_variant 0.29 isoniazid
dnaA 1314 c.1314A>G synonymous_variant 0.3 isoniazid
dnaA 1317 c.1317A>G synonymous_variant 0.3 isoniazid
dnaA 1320 c.1320G>C synonymous_variant 0.32 isoniazid
dnaA 1404 c.1404T>C synonymous_variant 0.29 isoniazid
dnaA 1407 c.1407T>C synonymous_variant 0.29 isoniazid
dnaA 1413 c.1413A>C synonymous_variant 0.27 isoniazid
dnaA 1416 c.1416C>G synonymous_variant 0.26 isoniazid
dnaA 1428 c.1428C>G synonymous_variant 0.28 isoniazid
gyrB 6268 c.1029C>G synonymous_variant 0.55 levofloxacin
moxifloxacin
gyrB 6286 c.1047T>C synonymous_variant 0.5 levofloxacin
moxifloxacin
gyrB 6319 c.1080G>C synonymous_variant 0.44 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrB 6346 c.1107C>T synonymous_variant 0.44 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6362 c.-940T>C upstream_gene_variant 0.47 levofloxacin
moxifloxacin
gyrA 6376 c.-926G>A upstream_gene_variant 0.43 levofloxacin
moxifloxacin
gyrA 6379 c.-923C>G upstream_gene_variant 0.46 levofloxacin
moxifloxacin
gyrA 6742 c.-560A>G upstream_gene_variant 0.5 levofloxacin
moxifloxacin
gyrB 6745 c.1506T>G synonymous_variant 0.5 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6751 c.-551G>C upstream_gene_variant 0.5 levofloxacin
moxifloxacin
gyrA 6760 c.-542G>C upstream_gene_variant 0.46 levofloxacin
moxifloxacin
gyrB 6763 c.1524G>C synonymous_variant 0.5 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6952 c.1713C>G synonymous_variant 0.38 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6967 c.-335T>C upstream_gene_variant 0.47 levofloxacin
moxifloxacin
gyrA 6973 c.-329G>C upstream_gene_variant 0.5 levofloxacin
moxifloxacin
gyrA 6982 c.-320A>C upstream_gene_variant 0.5 levofloxacin
moxifloxacin
gyrA 7006 c.-296T>C upstream_gene_variant 0.58 levofloxacin
moxifloxacin
gyrA 7007 c.-295C>T upstream_gene_variant 0.58 levofloxacin
moxifloxacin
gyrA 7010 c.-292C>T upstream_gene_variant 0.58 levofloxacin
moxifloxacin
gyrA 7015 c.-287G>A upstream_gene_variant 0.64 levofloxacin
moxifloxacin
gyrA 7018 c.-284G>A upstream_gene_variant 0.64 levofloxacin
moxifloxacin
gyrB 7023 p.Leu595Gln missense_variant 0.64 levofloxacin
moxifloxacin
gyrA 7033 c.-269G>C upstream_gene_variant 0.7 levofloxacin
moxifloxacin
gyrA 7347 p.Glu16Gln missense_variant 0.5 levofloxacin
moxifloxacin
gyrA 7355 c.54T>C synonymous_variant 0.5 levofloxacin
moxifloxacin
gyrA 7361 c.60C>T synonymous_variant 0.54 levofloxacin
moxifloxacin
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7391 c.90C>T synonymous_variant 0.62 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7394 c.93T>C synonymous_variant 0.58 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7571 c.270G>C synonymous_variant 0.56 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7595 c.294C>G synonymous_variant 0.53 levofloxacin
moxifloxacin
gyrA 7601 c.300C>G synonymous_variant 0.53 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7607 c.306C>G synonymous_variant 0.57 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7625 c.324G>C synonymous_variant 0.55 levofloxacin
moxifloxacin
gyrA 7796 c.495G>C synonymous_variant 0.5 levofloxacin
moxifloxacin
gyrA 7799 c.498A>G synonymous_variant 0.5 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7814 c.513C>G synonymous_variant 0.5 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7823 c.522G>C synonymous_variant 0.5 levofloxacin
moxifloxacin
gyrA 8330 c.1029C>G synonymous_variant 0.46 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8636 c.1335A>C synonymous_variant 0.73 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8642 c.1341A>G synonymous_variant 0.69 levofloxacin
moxifloxacin
gyrA 8672 c.1371A>G synonymous_variant 0.67 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8678 c.1377G>A synonymous_variant 0.67 levofloxacin
moxifloxacin
gyrA 8897 c.1596T>C synonymous_variant 0.5 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8903 c.1602T>C synonymous_variant 0.44 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8933 c.1632G>C synonymous_variant 0.55 levofloxacin
moxifloxacin
gyrA 8939 c.1638T>C synonymous_variant 0.6 levofloxacin
moxifloxacin
gyrA 8942 c.1641G>C synonymous_variant 0.6 levofloxacin
moxifloxacin
gyrA 8946 c.1645_1647delTTGinsCTC synonymous_variant 0.6 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9161 c.1860C>G synonymous_variant 0.64 levofloxacin
moxifloxacin
gyrA 9182 c.1881T>C synonymous_variant 0.73 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9191 c.1890G>C synonymous_variant 0.73 levofloxacin
moxifloxacin
gyrA 9200 c.1899A>G synonymous_variant 0.6 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9323 c.2022C>G synonymous_variant 0.75 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9335 c.2034G>C synonymous_variant 0.67 levofloxacin
moxifloxacin
nusG 734376 c.123G>A synonymous_variant 0.5 rifampicin
nusG 734407 p.Val52Ile missense_variant 0.52 rifampicin
nusG 734421 c.168A>G synonymous_variant 0.55 rifampicin
nusG 734424 c.171G>A synonymous_variant 0.48 rifampicin
nusG 734442 c.189G>A synonymous_variant 0.45 rifampicin
nusG 734451 c.198G>C synonymous_variant 0.5 rifampicin
nusG 734457 c.204C>G synonymous_variant 0.5 rifampicin
nusG 734472 c.219T>C synonymous_variant 0.6 rifampicin
nusG 734475 c.222T>C synonymous_variant 0.6 rifampicin Not assoc w R - Interim
nusG 734499 c.246G>C synonymous_variant 0.75 rifampicin
nusG 734532 c.279A>G synonymous_variant 0.77 rifampicin Not assoc w R - Interim
nusG 734541 c.288A>G synonymous_variant 0.77 rifampicin Not assoc w R - Interim
nusG 734882 p.Ala210Gly missense_variant 0.7 rifampicin
nusG 734886 c.633A>G synonymous_variant 0.7 rifampicin
nusG 734910 c.657C>G synonymous_variant 0.6 rifampicin
nusG 734913 c.660C>G synonymous_variant 0.6 rifampicin
rpoB 760091 c.285G>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 760101 c.295T>C synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoB 760112 c.306T>C synonymous_variant 0.56 rifampicin
rpoB 760118 c.312T>G synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoB 760121 c.315T>C synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoB 760130 p.Asp108Glu missense_variant 0.71 rifampicin Uncertain significance
rpoB 760139 c.333A>G synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoB 760142 c.336C>G synonymous_variant 0.65 rifampicin
rpoB 760181 c.375T>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 760223 c.417T>C synonymous_variant 0.52 rifampicin
rpoB 760235 c.429T>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoB 760283 c.477G>C synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoB 760298 c.492G>C synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoB 760307 c.501T>C synonymous_variant 0.86 rifampicin
rpoB 760310 c.504G>C synonymous_variant 0.86 rifampicin
rpoB 760328 c.522G>C synonymous_variant 0.85 rifampicin
rpoB 760331 c.525G>C synonymous_variant 0.85 rifampicin
rpoB 760340 c.534G>T synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoB 760361 c.555T>C synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoB 760412 c.606C>G synonymous_variant 0.8 rifampicin
rpoB 760424 c.618C>G synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoB 760430 c.624T>C synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoB 760481 c.675G>C synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoB 760484 c.678A>G synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoB 760522 p.Ser239Asn missense_variant 0.75 rifampicin Uncertain significance
rpoB 760532 c.726T>C synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoB 760533 p.Val243Thr missense_variant 0.69 rifampicin
rpoB 760541 c.735G>C synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoB 760547 c.741G>C synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoB 760563 p.Arg253Met missense_variant 0.73 rifampicin Uncertain significance
rpoB 760591 p.Val262Ala missense_variant 0.77 rifampicin
rpoB 760611 c.805T>C synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoB 760646 c.840C>G synonymous_variant 0.79 rifampicin Not assoc w R - Interim
rpoB 760655 c.849A>G synonymous_variant 0.79 rifampicin Not assoc w R - Interim
rpoB 760661 c.855A>C synonymous_variant 0.79 rifampicin Not assoc w R - Interim
rpoB 760670 c.864G>C synonymous_variant 0.77 rifampicin
rpoB 760674 c.868T>C synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoB 760679 c.873A>G synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoB 760683 c.877T>C synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoB 760715 c.909C>G synonymous_variant 0.64 rifampicin
rpoB 760718 c.912C>T synonymous_variant 0.64 rifampicin
rpoB 760724 c.918T>C synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoB 760730 c.924T>C synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoB 760886 c.1080A>G synonymous_variant 0.46 rifampicin
rpoB 760925 c.1119T>C synonymous_variant 0.43 rifampicin
rpoB 760928 c.1122G>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 760931 c.1125C>G synonymous_variant 0.43 rifampicin
rpoB 760934 c.1128C>T synonymous_variant 0.43 rifampicin
rpoB 760946 c.1140A>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 760982 c.1176G>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 760985 c.1179G>C synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoB 760991 c.1185G>C synonymous_variant 0.58 rifampicin
rpoB 761102 c.1296A>G synonymous_variant 1.0 rifampicin
rpoB 761129 c.1323G>C synonymous_variant 0.85 rifampicin Not assoc w R - Interim
rpoB 761132 c.1326G>T synonymous_variant 0.85 rifampicin Not assoc w R - Interim
rpoB 761133 c.1327T>C synonymous_variant 0.85 rifampicin Not assoc w R - Interim
rpoB 761150 c.1344A>C synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoB 761153 c.1347G>C synonymous_variant 0.82 rifampicin
rpoB 761306 c.1500C>G synonymous_variant 0.67 rifampicin
rpoB 761327 c.1521A>G synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoB 761330 c.1524G>C synonymous_variant 0.6 rifampicin
rpoB 761531 c.1725C>G synonymous_variant 0.83 rifampicin
rpoB 761537 c.1731C>G synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoB 761570 c.1764T>C synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoB 761573 c.1767C>G synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoB 761579 c.1773G>C synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoB 761606 c.1800C>G synonymous_variant 0.69 rifampicin
rpoB 761612 c.1806G>C synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoB 761615 c.1809A>C synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoB 761636 c.1830G>T synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoB 761645 c.1839C>G synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoB 761648 c.1842T>C synonymous_variant 0.53 rifampicin
rpoB 761657 c.1851C>G synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoB 761675 c.1869G>C synonymous_variant 0.57 rifampicin
rpoB 761885 c.2079T>C synonymous_variant 0.67 rifampicin
rpoB 761906 c.2100C>G synonymous_variant 0.62 rifampicin
rpoB 761909 c.2103T>C synonymous_variant 0.62 rifampicin
rpoB 761912 c.2106T>C synonymous_variant 0.62 rifampicin
rpoB 761915 p.Asp703Glu missense_variant 0.57 rifampicin
rpoB 761916 p.Asp704Asn missense_variant 0.57 rifampicin
rpoB 761948 c.2142G>C synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoB 761954 c.2148C>G synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoB 762008 c.2202C>T synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoB 762014 c.2208C>T synonymous_variant 0.53 rifampicin
rpoB 762017 c.2211A>G synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoB 762053 c.2247T>C synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoB 762062 c.2256T>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 762233 c.2427G>C synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoB 762246 c.2440C>T synonymous_variant 0.7 rifampicin
rpoB 762254 c.2448T>G synonymous_variant 0.73 rifampicin
rpoB 762257 c.2451C>G synonymous_variant 0.8 rifampicin
rpoB 762266 c.2460T>C synonymous_variant 0.8 rifampicin
rpoB 762284 c.2478G>C synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoB 762434 c.2628T>G synonymous_variant 0.58 rifampicin Not assoc w R
rpoC 762509 c.-861T>G upstream_gene_variant 0.73 rifampicin
rpoB 762510 p.Ala902Pro missense_variant 0.73 rifampicin Uncertain significance
rpoC 762521 c.-849C>T upstream_gene_variant 0.8 rifampicin
rpoB 762827 c.3021G>C synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoB 762857 c.3051C>G synonymous_variant 0.79 rifampicin Not assoc w R - Interim
rpoB 762860 c.3054G>C synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoB 762863 c.3057T>C synonymous_variant 0.85 rifampicin Not assoc w R - Interim
rpoB 762929 c.3123G>C synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoB 763085 c.3279C>G synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoC 763402 c.33C>G synonymous_variant 0.6 rifampicin
rpoC 763411 c.42T>G synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoC 763414 c.45T>C synonymous_variant 0.62 rifampicin
rpoC 763441 c.72C>T synonymous_variant 0.65 rifampicin
rpoC 763444 c.75T>C synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoC 763456 c.87A>G synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoC 763486 c.117T>G synonymous_variant 0.62 rifampicin
rpoC 763492 c.123G>C synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoC 763528 c.159G>A synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>C synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoC 763573 c.204G>C synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoC 763594 c.225C>T synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoC 763603 c.234C>T synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoC 763606 c.237C>T synonymous_variant 0.6 rifampicin
rpoC 763636 c.267T>C synonymous_variant 0.57 rifampicin
rpoC 763717 c.348T>C synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoC 763723 c.354G>C synonymous_variant 0.64 rifampicin
rpoC 763732 c.363C>G synonymous_variant 0.5 rifampicin
rpoC 763741 c.372C>T synonymous_variant 0.56 rifampicin
rpoC 763744 c.375G>C synonymous_variant 0.56 rifampicin
rpoC 763765 c.396T>C synonymous_variant 0.57 rifampicin
rpoC 763774 c.405G>C synonymous_variant 0.57 rifampicin
rpoC 763807 c.438T>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 763888 c.519G>C synonymous_variant 0.5 rifampicin
rpoC 763891 c.522G>C synonymous_variant 0.5 rifampicin
rpoC 763894 c.525A>G synonymous_variant 0.47 rifampicin
rpoC 763900 c.531G>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 763915 c.546C>T synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoC 764032 p.Asp221Glu missense_variant 0.54 rifampicin
rpoC 764040 p.Ser224Thr missense_variant 0.5 rifampicin
rpoC 764044 c.675T>C synonymous_variant 0.5 rifampicin
rpoC 764059 c.690G>T synonymous_variant 0.56 rifampicin
rpoC 764083 c.714A>G synonymous_variant 0.53 rifampicin
rpoC 764098 c.729A>G synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoC 764101 c.732C>G synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoC 764102 p.Val245Ile missense_variant 0.53 rifampicin
rpoC 764112 p.Tyr248Phe missense_variant 0.62 rifampicin
rpoC 764116 c.747C>T synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoC 764131 c.762T>C synonymous_variant 0.62 rifampicin
rpoC 764236 c.867G>A synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoC 764248 c.879C>G synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoC 764257 c.888G>C synonymous_variant 0.75 rifampicin
rpoC 764266 c.897T>C synonymous_variant 0.69 rifampicin
rpoC 764269 c.900G>C synonymous_variant 0.62 rifampicin
rpoC 764272 c.903G>C synonymous_variant 0.67 rifampicin
rpoC 764278 c.909A>G synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoC 764338 c.969G>A synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoC 764353 c.984G>C synonymous_variant 0.56 rifampicin
rpoC 764405 c.1036A>C synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoC 764489 c.1120C>T synonymous_variant 0.69 rifampicin
rpoC 764497 c.1128A>G synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoC 764510 c.1141C>T synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoC 764521 c.1152T>C synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoC 764527 c.1158C>T synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoC 764536 c.1167G>C synonymous_variant 0.73 rifampicin
rpoC 764539 c.1170C>G synonymous_variant 0.79 rifampicin Not assoc w R - Interim
rpoC 764548 c.1179G>A synonymous_variant 0.78 rifampicin
rpoC 764551 c.1182G>C synonymous_variant 0.78 rifampicin
rpoC 764554 c.1185C>T synonymous_variant 0.78 rifampicin
rpoC 764560 c.1191T>C synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoC 764566 c.1197C>G synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoC 764575 c.1206T>G synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoC 764593 c.1224C>T synonymous_variant 0.65 rifampicin
rpoC 764611 c.1242G>T synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>C synonymous_variant 0.62 rifampicin
rpoC 764651 c.1282_1284delTCGinsAGC synonymous_variant 0.62 rifampicin
rpoC 764858 c.1489T>C synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoC 764872 c.1503A>G synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoC 764888 c.1519T>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoC 764911 c.1542A>G synonymous_variant 0.75 rifampicin
rpoC 764932 c.1563C>A synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoC 764948 c.1579T>C synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoC 764968 c.1599T>C synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoC 765700 c.2331T>C synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoC 765826 c.2457T>C synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoC 765835 c.2466C>T synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoC 765850 c.2481G>C synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoC 766054 c.2685C>G synonymous_variant 0.64 rifampicin
rpoC 766082 p.Ala905Gln missense_variant 0.58 rifampicin
rpoC 766096 c.2727G>C synonymous_variant 0.7 rifampicin
rpoC 766348 c.2979A>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 766357 c.2988C>T synonymous_variant 0.55 rifampicin
rpoC 766363 c.2994G>C synonymous_variant 0.55 rifampicin
rpoC 766366 c.2997C>G synonymous_variant 0.55 rifampicin
rpoC 766390 c.3021C>T synonymous_variant 0.55 rifampicin
rpoC 766462 c.3093G>C synonymous_variant 0.69 rifampicin
rpoC 766483 c.3114G>C synonymous_variant 0.64 rifampicin
rpoC 766484 p.Val1039Ile missense_variant 0.64 rifampicin Uncertain significance
rpoC 766492 c.3123T>C synonymous_variant 0.64 rifampicin
rpoC 766522 c.3153C>G synonymous_variant 0.71 rifampicin
rpoC 766528 c.3159T>C synonymous_variant 0.69 rifampicin
rpoC 766607 p.Ile1080Leu missense_variant 0.7 rifampicin
rpoC 766795 c.3426C>T synonymous_variant 0.64 rifampicin
rpoC 766801 c.3432C>G synonymous_variant 0.64 rifampicin
rpoC 766804 c.3435A>G synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoC 766861 c.3492G>C synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoC 766864 c.3495G>C synonymous_variant 0.69 rifampicin
rpoC 766900 c.3531T>C synonymous_variant 0.69 rifampicin
rpoC 767119 c.3750A>G synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoC 767134 c.3765C>A synonymous_variant 0.6 rifampicin
rpoC 767180 p.Ala1271Gln missense_variant 0.53 rifampicin
rpoC 767191 c.3822C>G synonymous_variant 0.47 rifampicin Not assoc w R - Interim
mmpL5 777176 p.Glu435Asp missense_variant 0.47 bedaquiline
clofazimine
mmpL5 777191 c.1290C>G synonymous_variant 0.4 bedaquiline
clofazimine
mmpL5 777194 c.1287A>G synonymous_variant 0.4 bedaquiline
clofazimine
rpsL 781571 c.12C>T synonymous_variant 0.5 streptomycin
rpsL 781595 c.36T>C synonymous_variant 0.5 streptomycin
rpsL 781605 p.Ile16Val missense_variant 0.5 streptomycin Uncertain significance
rpsL 781608 p.Ser17Ala missense_variant 0.5 streptomycin
rpsL 781628 c.69T>C synonymous_variant 0.5 streptomycin Not assoc w R - Interim
rpsL 781631 c.72G>C synonymous_variant 0.5 streptomycin
rpsL 781649 c.90T>C synonymous_variant 0.43 streptomycin
rpsL 781655 c.96T>C synonymous_variant 0.5 streptomycin
rpsL 781700 c.141G>C synonymous_variant 0.5 streptomycin
rpsL 781703 c.144G>T synonymous_variant 0.5 streptomycin
rpsL 781715 c.156T>C synonymous_variant 0.58 streptomycin
rpsL 781728 c.169T>C synonymous_variant 0.67 streptomycin
rpsL 781736 c.177T>C synonymous_variant 0.69 streptomycin
rpsL 781742 c.183C>T synonymous_variant 0.69 streptomycin
rpsL 781748 c.189C>G synonymous_variant 0.77 streptomycin
rpsL 781754 c.195G>C synonymous_variant 0.71 streptomycin
rpsL 781760 c.201T>C synonymous_variant 0.62 streptomycin
rpsL 781772 c.213C>A synonymous_variant 0.62 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.54 streptomycin
rpsL 781898 c.339A>T synonymous_variant 0.5 streptomycin
rpsL 781916 c.357T>C synonymous_variant 0.55 streptomycin
rplC 800627 c.-182C>T upstream_gene_variant 0.54 linezolid
rplC 800648 c.-161A>T upstream_gene_variant 0.57 linezolid
rplC 800654 c.-155T>C upstream_gene_variant 0.55 linezolid
rplC 800693 c.-116A>G upstream_gene_variant 0.5 linezolid
rplC 800703 c.-106T>C upstream_gene_variant 0.55 linezolid
rplC 800715 c.-94A>C upstream_gene_variant 0.45 linezolid
rplC 800720 c.-89T>C upstream_gene_variant 0.43 linezolid
rplC 800723 c.-86C>G upstream_gene_variant 0.43 linezolid
Rv1129c 1254562 c.-28T>C upstream_gene_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
isoniazid Not assoc w R
rifampicin Not assoc w R
fbiC 1303539 c.609G>C synonymous_variant 0.71 pretomanid
delamanid
clofazimine
fbiC 1303545 c.615A>G synonymous_variant 0.71 pretomanid
delamanid
clofazimine
fbiC 1303575 c.645G>C synonymous_variant 0.82 pretomanid
delamanid
clofazimine
fbiC 1303755 c.825T>C synonymous_variant 0.5 pretomanid
delamanid
clofazimine
fbiC 1303761 c.831T>C synonymous_variant 0.5 pretomanid
delamanid
clofazimine
fbiC 1303836 c.906G>C synonymous_variant 0.5 pretomanid
delamanid
clofazimine
fbiC 1303845 c.915C>G synonymous_variant 0.5 pretomanid
delamanid
clofazimine
fbiC 1303846 p.Phe306Val missense_variant 0.55 pretomanid
delamanid
clofazimine
fbiC 1304526 c.1596T>G synonymous_variant 0.64 pretomanid
delamanid
clofazimine
fbiC 1304535 c.1605G>A synonymous_variant 0.64 pretomanid
delamanid
clofazimine
fbiC 1304544 c.1614T>C synonymous_variant 0.58 pretomanid
delamanid
clofazimine
fbiC 1304545 p.Val539Thr missense_variant 0.58 pretomanid
delamanid
clofazimine
fbiC 1304553 c.1623C>T synonymous_variant 0.64 pretomanid
delamanid
clofazimine
fbiC 1304559 p.Glu543Asp missense_variant 0.69 pretomanid
delamanid
clofazimine
fbiC 1304565 c.1635C>G synonymous_variant 0.76 pretomanid
delamanid
clofazimine
fbiC 1304568 c.1638T>C synonymous_variant 0.76 pretomanid
delamanid
clofazimine
fbiC 1304580 c.1650T>C synonymous_variant 0.81 pretomanid
delamanid
clofazimine
fbiC 1304613 c.1683T>C synonymous_variant 0.64 pretomanid
delamanid
clofazimine
fbiC 1304742 c.1812T>C synonymous_variant 0.62 pretomanid
delamanid
clofazimine
fbiC 1304748 c.1818T>C synonymous_variant 0.62 pretomanid
delamanid
clofazimine
fbiC 1304757 c.1827A>G synonymous_variant 0.83 pretomanid
delamanid
clofazimine
fbiC 1304778 c.1848T>C synonymous_variant 0.73 pretomanid
delamanid
clofazimine
fbiC 1304784 c.1854T>C synonymous_variant 0.73 pretomanid
delamanid
clofazimine
fbiC 1304787 c.1857T>G synonymous_variant 0.71 pretomanid
delamanid
clofazimine
fbiC 1304808 c.1878C>G synonymous_variant 0.69 pretomanid
delamanid
clofazimine
fbiC 1304811 c.1881C>G synonymous_variant 0.69 pretomanid
delamanid
clofazimine
fbiC 1304817 c.1887T>C synonymous_variant 0.71 pretomanid
delamanid
clofazimine
fbiC 1304829 c.1899T>C synonymous_variant 0.69 pretomanid
delamanid
clofazimine
fbiC 1304832 c.1902C>T synonymous_variant 0.62 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R - Interim
fbiC 1304937 c.2007G>C synonymous_variant 0.53 pretomanid
delamanid
clofazimine
fbiC 1304958 c.2028T>G synonymous_variant 0.72 pretomanid
delamanid
clofazimine
fbiC 1304983 c.2053C>T synonymous_variant 0.75 pretomanid
delamanid
clofazimine
fbiC 1304994 c.2064A>G synonymous_variant 0.73 pretomanid
delamanid
clofazimine
fbiC 1304995 p.Leu689Met missense_variant 0.73 pretomanid
delamanid
clofazimine
fbiC 1305006 c.2076A>G synonymous_variant 0.71 pretomanid
delamanid
clofazimine
fbiC 1305012 c.2082G>C synonymous_variant 0.69 pretomanid
delamanid
clofazimine
fbiC 1305015 c.2085G>C synonymous_variant 0.67 pretomanid
delamanid
clofazimine
fbiC 1305021 c.2091C>G synonymous_variant 0.7 pretomanid
delamanid
clofazimine
fbiC 1305030 c.2100G>C synonymous_variant 0.7 pretomanid
delamanid
clofazimine
fbiC 1305372 c.2442G>A synonymous_variant 0.7 pretomanid
delamanid
clofazimine Not assoc w R - Interim
fbiC 1305405 c.2475A>G synonymous_variant 0.7 pretomanid
delamanid
clofazimine Not assoc w R - Interim
fbiC 1305417 c.2487C>G synonymous_variant 0.7 pretomanid
delamanid
clofazimine
rrs 1471923 n.78T>C non_coding_transcript_exon_variant 0.47 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1471925 n.80T>C non_coding_transcript_exon_variant 0.47 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1471932 n.87A>G non_coding_transcript_exon_variant 0.5 kanamycin
capreomycin
streptomycin
amikacin
rrs 1471934 n.89A>G non_coding_transcript_exon_variant 0.5 kanamycin
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472061 n.216A>T non_coding_transcript_exon_variant 0.4 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472075 n.230A>G non_coding_transcript_exon_variant 0.39 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1473105 n.1260G>A non_coding_transcript_exon_variant 0.53 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.8 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.82 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473290 n.1445C>T non_coding_transcript_exon_variant 0.54 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrl 1473756 n.99G>A non_coding_transcript_exon_variant 0.87 capreomycin
linezolid
rrl 1473758 n.101G>T non_coding_transcript_exon_variant 0.87 capreomycin Uncertain significance
linezolid
rrl 1473806 n.149C>T non_coding_transcript_exon_variant 0.81 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473877 n.220G>A non_coding_transcript_exon_variant 0.83 capreomycin
linezolid
rrl 1473898 n.241C>T non_coding_transcript_exon_variant 0.82 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473943 n.286G>T non_coding_transcript_exon_variant 0.65 capreomycin Uncertain significance
linezolid
rrl 1473945 n.288T>A non_coding_transcript_exon_variant 0.65 capreomycin Uncertain significance
linezolid
rrl 1473946 n.289A>T non_coding_transcript_exon_variant 0.65 capreomycin Uncertain significance
linezolid
rrl 1473986 n.329T>C non_coding_transcript_exon_variant 0.71 capreomycin
linezolid
rrl 1473987 n.330G>A non_coding_transcript_exon_variant 0.71 capreomycin
linezolid
rrl 1473995 n.338G>T non_coding_transcript_exon_variant 0.75 capreomycin
linezolid
rrl 1474001 n.344C>T non_coding_transcript_exon_variant 0.75 capreomycin Not assoc w R
linezolid Not assoc w R
rrl 1474009 n.352A>G non_coding_transcript_exon_variant 0.71 capreomycin
linezolid
rrl 1474012 n.355C>T non_coding_transcript_exon_variant 0.64 capreomycin
linezolid
rrl 1474093 n.436G>T non_coding_transcript_exon_variant 0.88 capreomycin
linezolid
rrl 1474099 n.442G>A non_coding_transcript_exon_variant 0.88 capreomycin
linezolid
rrl 1474103 n.446A>T non_coding_transcript_exon_variant 0.88 capreomycin
linezolid
rrl 1474140 n.483C>T non_coding_transcript_exon_variant 0.89 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.88 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474181 n.524C>T non_coding_transcript_exon_variant 0.83 capreomycin Uncertain significance
linezolid
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 0.59 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474291 n.635_649delTTCCTCTCCGGAGGA non_coding_transcript_exon_variant 0.53 capreomycin
linezolid
rrl 1474308 n.651G>T non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474310 n.653T>G non_coding_transcript_exon_variant 0.5 capreomycin
linezolid
rrl 1474356 n.699T>C non_coding_transcript_exon_variant 0.62 capreomycin Uncertain significance
linezolid
rrl 1474362 n.705A>G non_coding_transcript_exon_variant 0.6 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474639 n.982G>A non_coding_transcript_exon_variant 0.83 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.62 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.67 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474823 n.1166C>T non_coding_transcript_exon_variant 0.7 capreomycin
linezolid
rrl 1474831 n.1174A>G non_coding_transcript_exon_variant 0.68 capreomycin Uncertain significance
linezolid
rrl 1474904 n.1247G>A non_coding_transcript_exon_variant 0.48 capreomycin
linezolid
rrl 1474956 n.1299C>T non_coding_transcript_exon_variant 0.63 capreomycin
linezolid
rrl 1474960 n.1303C>G non_coding_transcript_exon_variant 0.61 capreomycin
linezolid
rrl 1474963 n.1306G>T non_coding_transcript_exon_variant 0.58 capreomycin Uncertain significance
linezolid
rrl 1474964 n.1307T>A non_coding_transcript_exon_variant 0.58 capreomycin
linezolid
rrl 1474965 n.1308G>C non_coding_transcript_exon_variant 0.58 capreomycin
linezolid
rrl 1474970 n.1313G>A non_coding_transcript_exon_variant 0.6 capreomycin
linezolid
rrl 1475006 n.1349A>T non_coding_transcript_exon_variant 0.54 capreomycin
linezolid
rrl 1475088 n.1431A>T non_coding_transcript_exon_variant 0.56 capreomycin
linezolid
rrl 1475199 n.1542G>A non_coding_transcript_exon_variant 0.73 capreomycin
linezolid
rrl 1475206 n.1549C>T non_coding_transcript_exon_variant 0.65 capreomycin Uncertain significance
linezolid
rrl 1475209 n.1552G>C non_coding_transcript_exon_variant 0.68 capreomycin Uncertain significance
linezolid
rrl 1475213 n.1556C>T non_coding_transcript_exon_variant 0.68 capreomycin Uncertain significance
linezolid
rrl 1475249 n.1592T>C non_coding_transcript_exon_variant 0.6 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475252 n.1595C>T non_coding_transcript_exon_variant 0.6 capreomycin
linezolid
rrl 1475266 n.1609T>C non_coding_transcript_exon_variant 0.59 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475267 n.1610G>A non_coding_transcript_exon_variant 0.59 capreomycin
linezolid
rrl 1475275 n.1618C>T non_coding_transcript_exon_variant 0.56 capreomycin
linezolid
rrl 1475276 n.1619T>C non_coding_transcript_exon_variant 0.56 capreomycin
linezolid
rrl 1475291 n.1634A>C non_coding_transcript_exon_variant 0.75 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475313 n.1656G>A non_coding_transcript_exon_variant 0.71 capreomycin
linezolid
rrl 1475315 n.1658A>T non_coding_transcript_exon_variant 0.71 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475355 n.1698C>T non_coding_transcript_exon_variant 0.8 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475369 n.1712G>T non_coding_transcript_exon_variant 0.76 capreomycin
linezolid
rrl 1475402 n.1745C>T non_coding_transcript_exon_variant 0.71 capreomycin
linezolid
rrl 1475419 n.1762C>T non_coding_transcript_exon_variant 0.7 capreomycin Uncertain significance
linezolid
rrl 1475429 n.1772G>A non_coding_transcript_exon_variant 0.75 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475436 n.1779C>T non_coding_transcript_exon_variant 0.71 capreomycin
linezolid
rrl 1475483 n.1826C>T non_coding_transcript_exon_variant 0.81 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475505 n.1848G>A non_coding_transcript_exon_variant 0.63 capreomycin Uncertain significance
linezolid
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.66 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475599 n.1942A>G non_coding_transcript_exon_variant 0.56 capreomycin
linezolid Uncertain significance
rrl 1475608 n.1951T>C non_coding_transcript_exon_variant 0.62 capreomycin Uncertain significance
linezolid
rrl 1475642 n.1985T>C non_coding_transcript_exon_variant 0.56 capreomycin
linezolid
rrl 1475657 n.2000A>G non_coding_transcript_exon_variant 0.56 capreomycin
linezolid
rrl 1475659 n.2002G>T non_coding_transcript_exon_variant 0.59 capreomycin
linezolid
rrl 1475761 n.2104_2106delCGCinsGT non_coding_transcript_exon_variant 0.48 capreomycin
linezolid
rrl 1475765 n.2111delG non_coding_transcript_exon_variant 0.48 capreomycin
linezolid
rrl 1475881 n.2224T>C non_coding_transcript_exon_variant 0.58 capreomycin
linezolid
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.86 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476031 n.2374C>T non_coding_transcript_exon_variant 0.76 capreomycin
linezolid
rrl 1476032 n.2375C>A non_coding_transcript_exon_variant 0.76 capreomycin
linezolid
rrl 1476033 n.2376T>C non_coding_transcript_exon_variant 0.76 capreomycin Uncertain significance
linezolid
rrl 1476034 n.2377C>A non_coding_transcript_exon_variant 0.76 capreomycin Uncertain significance
linezolid
rrl 1476045 n.2388G>T non_coding_transcript_exon_variant 0.76 capreomycin Uncertain significance
linezolid
rrl 1476047 n.2390G>T non_coding_transcript_exon_variant 0.76 capreomycin
linezolid
rrl 1476048 n.2391G>A non_coding_transcript_exon_variant 0.76 capreomycin
linezolid
rrl 1476049 n.2392C>T non_coding_transcript_exon_variant 0.76 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476086 n.2429G>A non_coding_transcript_exon_variant 0.68 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476089 n.2432T>C non_coding_transcript_exon_variant 0.68 capreomycin
linezolid
rrl 1476095 n.2438C>G non_coding_transcript_exon_variant 0.67 capreomycin
linezolid
rrl 1476105 n.2448_2449delGAinsT non_coding_transcript_exon_variant 0.53 capreomycin
linezolid
rrl 1476115 n.2458T>C non_coding_transcript_exon_variant 0.6 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476117 n.2460G>C non_coding_transcript_exon_variant 0.6 capreomycin
linezolid
rrl 1476214 n.2557G>A non_coding_transcript_exon_variant 0.7 capreomycin
linezolid
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.67 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.73 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476583 n.2926G>A non_coding_transcript_exon_variant 0.7 capreomycin Uncertain significance
linezolid
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.7 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476594 n.2937C>T non_coding_transcript_exon_variant 0.67 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476597 n.2940G>A non_coding_transcript_exon_variant 0.63 capreomycin Uncertain significance
linezolid
rrl 1476603 n.2946G>A non_coding_transcript_exon_variant 0.62 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476608 n.2951C>G non_coding_transcript_exon_variant 0.61 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476689 n.3032A>T non_coding_transcript_exon_variant 0.67 capreomycin
linezolid
rrl 1476690 n.3033C>T non_coding_transcript_exon_variant 0.67 capreomycin Uncertain significance
linezolid
rrl 1476693 n.3036G>A non_coding_transcript_exon_variant 0.67 capreomycin
linezolid
rrl 1476695 n.3038T>A non_coding_transcript_exon_variant 0.69 capreomycin
linezolid
rrl 1476716 n.3059A>C non_coding_transcript_exon_variant 0.63 capreomycin Uncertain significance
linezolid
rrl 1476726 n.3069A>G non_coding_transcript_exon_variant 0.64 capreomycin
linezolid
rrl 1476732 n.3075T>C non_coding_transcript_exon_variant 0.59 capreomycin
linezolid
rrl 1476733 n.3076C>T non_coding_transcript_exon_variant 0.59 capreomycin
linezolid
rrl 1476750 n.3093T>C non_coding_transcript_exon_variant 0.43 capreomycin
linezolid
inhA 1673916 c.-286A>C upstream_gene_variant 0.5 isoniazid
ethionamide
inhA 1673917 c.-285G>C upstream_gene_variant 0.5 isoniazid
ethionamide
inhA 1673922 c.-280T>C upstream_gene_variant 0.54 isoniazid
ethionamide
inhA 1673941 c.-261G>T upstream_gene_variant 0.58 isoniazid
ethionamide
inhA 1673946 c.-256C>G upstream_gene_variant 0.58 isoniazid
ethionamide
inhA 1673955 c.-247G>C upstream_gene_variant 0.64 isoniazid
ethionamide
inhA 1673961 c.-241A>C upstream_gene_variant 0.7 isoniazid
ethionamide
inhA 1674703 c.502T>C synonymous_variant 0.5 isoniazid
ethionamide
inhA 1674708 c.507G>A synonymous_variant 0.47 isoniazid
ethionamide
inhA 1674718 c.517A>C synonymous_variant 0.47 isoniazid
ethionamide
inhA 1674726 c.525G>A synonymous_variant 0.47 isoniazid
ethionamide
inhA 1674738 c.537C>G synonymous_variant 0.46 isoniazid
ethionamide
inhA 1674846 p.Ile215Met missense_variant 0.73 isoniazid
ethionamide
inhA 1674864 c.663C>T synonymous_variant 0.8 isoniazid Not assoc w R - Interim
ethionamide Not assoc w R - Interim
inhA 1674870 c.669T>C synonymous_variant 0.82 isoniazid
ethionamide
inhA 1674879 c.678T>C synonymous_variant 0.9 isoniazid
ethionamide
inhA 1674900 c.699G>A synonymous_variant 0.75 isoniazid
ethionamide
inhA 1674903 c.702T>C synonymous_variant 0.73 isoniazid
ethionamide
inhA 1674904 p.Ala235Pro missense_variant 0.73 isoniazid
ethionamide
inhA 1674909 c.708G>A synonymous_variant 0.67 isoniazid
ethionamide
inhA 1674942 c.741T>G synonymous_variant 0.58 isoniazid
ethionamide
rpsA 1833589 c.48A>T synonymous_variant 0.8 pyrazinamide
rpsA 1833595 c.54T>C synonymous_variant 0.8 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.8 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.8 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.79 pyrazinamide
rpsA 1833874 c.333T>C synonymous_variant 0.81 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 1.0 pyrazinamide
rpsA 1833940 c.399C>G synonymous_variant 1.0 pyrazinamide
rpsA 1833971 c.430C>T synonymous_variant 1.0 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.93 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.83 pyrazinamide
rpsA 1834021 c.480C>T synonymous_variant 0.8 pyrazinamide
rpsA 1834030 c.489C>G synonymous_variant 0.82 pyrazinamide
rpsA 1834195 c.654G>C synonymous_variant 0.9 pyrazinamide
rpsA 1834210 c.669C>T synonymous_variant 1.0 pyrazinamide
rpsA 1834222 c.681T>C synonymous_variant 1.0 pyrazinamide
rpsA 1834249 c.708T>C synonymous_variant 0.65 pyrazinamide
rpsA 1834261 c.720A>G synonymous_variant 0.71 pyrazinamide Not assoc w R - Interim
rpsA 1834264 c.723G>C synonymous_variant 0.71 pyrazinamide
rpsA 1834609 c.1068T>C synonymous_variant 0.71 pyrazinamide
rpsA 1834633 c.1092A>G synonymous_variant 0.64 pyrazinamide
rpsA 1834639 c.1098T>C synonymous_variant 0.71 pyrazinamide
rpsA 1834654 p.Glu371Asp missense_variant 0.75 pyrazinamide
rpsA 1834732 c.1191T>C synonymous_variant 0.58 pyrazinamide
rpsA 1834733 p.Ala398Ser missense_variant 0.62 pyrazinamide
bacA 2064972 c.-244T>C upstream_gene_variant 0.75 kanamycin
capreomycin
streptomycin
amikacin
bacA 2064978 c.-250G>C upstream_gene_variant 0.77 kanamycin
capreomycin
streptomycin
amikacin
bacA 2064979 c.-251C>T upstream_gene_variant 0.77 kanamycin
capreomycin
streptomycin
amikacin
bacA 2064984 c.-256A>G upstream_gene_variant 0.73 kanamycin
capreomycin
streptomycin
amikacin
bacA 2064993 c.-265T>C upstream_gene_variant 0.73 kanamycin
capreomycin
streptomycin
amikacin
ndh 2102686 c.357G>C synonymous_variant 0.53 isoniazid
delamanid
ethionamide
ndh 2102695 c.348C>T synonymous_variant 0.56 isoniazid
delamanid
ethionamide
ndh 2102700 c.343C>T synonymous_variant 0.56 isoniazid
delamanid
ethionamide
ndh 2102710 c.333C>T synonymous_variant 0.56 isoniazid
delamanid
ethionamide
kasA 2518540 c.426T>C synonymous_variant 0.58 isoniazid
kasA 2518561 c.447T>C synonymous_variant 0.46 isoniazid
kasA 2518567 c.453G>C synonymous_variant 0.43 isoniazid
kasA 2518768 c.654C>T synonymous_variant 0.7 isoniazid
kasA 2518777 c.663C>T synonymous_variant 0.67 isoniazid
kasA 2518783 c.669T>C synonymous_variant 0.71 isoniazid
kasA 2518789 c.675G>C synonymous_variant 0.69 isoniazid
kasA 2518792 c.678C>A synonymous_variant 0.77 isoniazid
kasA 2518795 c.681C>G synonymous_variant 0.73 isoniazid
kasA 2518825 c.711T>C synonymous_variant 0.73 isoniazid
kasA 2518864 c.750G>C synonymous_variant 0.62 isoniazid
ahpC 2726657 c.465A>C synonymous_variant 0.46 isoniazid Not assoc w R - Interim
ahpC 2726669 p.Asp159Glu missense_variant 0.47 isoniazid
ahpC 2726672 c.480G>A synonymous_variant 0.47 isoniazid Not assoc w R - Interim
ahpC 2726675 c.483A>G synonymous_variant 0.47 isoniazid
ahpC 2726681 c.489A>C synonymous_variant 0.47 isoniazid Not assoc w R - Interim
ahpC 2726687 c.495C>G synonymous_variant 0.5 isoniazid
ahpC 2726693 c.501C>G synonymous_variant 0.5 isoniazid
folC 2747394 p.Ile69Val missense_variant 0.5 para-aminosalicylic_acid
folC 2747395 c.204T>C synonymous_variant 0.5 para-aminosalicylic_acid
Rv2477c 2782498 c.1545C>T synonymous_variant 0.55 kanamycin Not assoc w R
levofloxacin Not assoc w R
moxifloxacin Not assoc w R
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R
ethambutol Not assoc w R
amikacin Not assoc w R
Rv2477c 2783140 c.903C>G synonymous_variant 0.58 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783194 c.849A>G synonymous_variant 0.53 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783221 c.822G>C synonymous_variant 0.5 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783224 c.819C>G synonymous_variant 0.47 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783230 c.813T>G synonymous_variant 0.47 kanamycin
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin
Rv2477c 2783235 c.808T>C synonymous_variant 0.5 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783683 c.360A>G synonymous_variant 0.56 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783700 p.Thr115Ser missense_variant 0.61 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783718 c.325T>C synonymous_variant 0.5 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783719 c.324A>G synonymous_variant 0.5 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
thyX 3067439 c.507A>G synonymous_variant 0.73 para-aminosalicylic_acid
thyX 3067445 c.501C>G synonymous_variant 0.8 para-aminosalicylic_acid
thyX 3067457 c.489C>G synonymous_variant 0.7 para-aminosalicylic_acid
thyX 3067462 c.484C>T synonymous_variant 0.7 para-aminosalicylic_acid
thyX 3067465 p.Ile161Val missense_variant 0.7 para-aminosalicylic_acid
thyX 3067466 c.480G>C synonymous_variant 0.7 para-aminosalicylic_acid
thyX 3067559 c.387C>G synonymous_variant 0.67 para-aminosalicylic_acid
thyX 3067565 p.Asp127Glu missense_variant 0.69 para-aminosalicylic_acid
thyX 3067570 p.Ala126Pro missense_variant 0.71 para-aminosalicylic_acid
thyX 3067577 c.369G>A synonymous_variant 0.67 para-aminosalicylic_acid
thyX 3067601 p.Arg115His missense_variant 0.54 para-aminosalicylic_acid
thyX 3067611 p.Lys112Thr missense_variant 0.57 para-aminosalicylic_acid
thyX 3067619 c.327A>C synonymous_variant 0.57 para-aminosalicylic_acid
thyX 3067631 c.315C>G synonymous_variant 0.46 para-aminosalicylic_acid
thyX 3067634 c.312C>G synonymous_variant 0.46 para-aminosalicylic_acid
thyX 3067637 c.309G>A synonymous_variant 0.5 para-aminosalicylic_acid
thyX 3067736 c.210C>T synonymous_variant 0.64 para-aminosalicylic_acid
thyX 3067781 c.165C>G synonymous_variant 0.62 para-aminosalicylic_acid
thyX 3067793 c.153T>C synonymous_variant 0.57 para-aminosalicylic_acid
thyX 3067799 c.147G>A synonymous_variant 0.57 para-aminosalicylic_acid
thyX 3067802 c.144C>G synonymous_variant 0.53 para-aminosalicylic_acid
thyX 3067814 c.132T>C synonymous_variant 0.5 para-aminosalicylic_acid
thyA 3074187 c.285T>C synonymous_variant 0.46 para-aminosalicylic_acid
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
mtrB 3626704 c.-91C>T upstream_gene_variant 0.46 rifampicin
bedaquiline
mtrB 3626711 c.-98T>C upstream_gene_variant 0.46 rifampicin
bedaquiline
mtrA 3626723 c.627C>T synonymous_variant 0.5 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626726 c.-113T>C upstream_gene_variant 0.5 rifampicin
bedaquiline
mtrB 3626729 c.-116G>A upstream_gene_variant 0.5 rifampicin
bedaquiline
mtrB 3626732 c.-119A>G upstream_gene_variant 0.5 rifampicin
bedaquiline
mtrA 3626759 c.591T>C synonymous_variant 0.59 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626798 c.-185T>C upstream_gene_variant 0.56 rifampicin
bedaquiline
mtrA 3626804 c.546A>G synonymous_variant 0.56 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627104 c.-491C>G upstream_gene_variant 0.5 rifampicin
bedaquiline
mtrA 3627119 c.231T>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627122 c.-509T>C upstream_gene_variant 0.5 rifampicin
bedaquiline
mtrA 3627146 c.204C>T synonymous_variant 0.65 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627167 c.-554T>C upstream_gene_variant 0.71 rifampicin
bedaquiline
mtrB 3627181 c.-568T>C upstream_gene_variant 0.63 rifampicin
bedaquiline
mtrB 3627182 c.-569T>C upstream_gene_variant 0.61 rifampicin
bedaquiline
mtrA 3627188 c.162A>G synonymous_variant 0.61 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627209 c.-596G>A upstream_gene_variant 0.59 rifampicin
bedaquiline
mtrA 3627221 c.129C>T synonymous_variant 0.67 rifampicin Not assoc w R - Interim
bedaquiline
mtrA 3627227 c.123T>C synonymous_variant 0.67 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627233 c.-620T>C upstream_gene_variant 0.64 rifampicin
bedaquiline
mtrB 3627263 c.-650C>T upstream_gene_variant 0.62 rifampicin
bedaquiline
mtrB 3627266 c.-653A>G upstream_gene_variant 0.62 rifampicin
bedaquiline
mtrB 3627272 c.-659G>T upstream_gene_variant 0.58 rifampicin
bedaquiline
mtrB 3627275 c.-662G>T upstream_gene_variant 0.7 rifampicin
bedaquiline
mtrB 3627296 c.-683T>C upstream_gene_variant 0.7 rifampicin
bedaquiline
mtrB 3627299 c.-688_-686delTTGinsCTA upstream_gene_variant 0.7 rifampicin
bedaquiline
rpoA 3877553 p.Glu319Gln missense_variant 0.62 rifampicin
rpoA 3877571 p.Pro313Ala missense_variant 0.73 rifampicin
rpoA 3877587 c.921A>G synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoA 3877613 p.Ile299Val missense_variant 0.82 rifampicin
rpoA 3877656 c.852T>G synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoA 3877668 c.840A>G synonymous_variant 0.9 rifampicin
rpoA 3877679 p.Ala277Ser missense_variant 0.93 rifampicin
rpoA 3877686 c.822A>G synonymous_variant 0.93 rifampicin Not assoc w R - Interim
rpoA 3877692 c.816G>C synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoA 3877704 c.804G>C synonymous_variant 0.93 rifampicin
rpoA 3877737 c.771G>C synonymous_variant 0.88 rifampicin
rpoA 3877743 c.765T>C synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoA 3877764 c.744C>G synonymous_variant 0.78 rifampicin Not assoc w R - Interim
rpoA 3877770 c.738A>G synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoA 3877776 c.732T>C synonymous_variant 0.78 rifampicin Not assoc w R - Interim
rpoA 3877782 c.726T>C synonymous_variant 0.79 rifampicin Not assoc w R - Interim
rpoA 3877791 c.717C>G synonymous_variant 0.8 rifampicin
rpoA 3877818 c.690A>G synonymous_variant 0.85 rifampicin Not assoc w R - Interim
rpoA 3877839 c.669G>C synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoA 3877848 c.660C>T synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoA 3877857 c.651G>A synonymous_variant 0.69 rifampicin
rpoA 3877866 c.642G>C synonymous_variant 0.73 rifampicin
rpoA 3877875 c.633T>G synonymous_variant 0.68 rifampicin
rpoA 3877878 c.630G>C synonymous_variant 0.67 rifampicin
rpoA 3877890 c.618C>T synonymous_variant 0.7 rifampicin
rpoA 3877896 c.612G>C synonymous_variant 0.65 rifampicin
rpoA 3877900 p.Ser203Asn missense_variant 0.61 rifampicin
rpoA 3877905 c.603A>G synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoA 3877909 p.Asn200Ser missense_variant 0.65 rifampicin
rpoA 3877920 c.588G>C synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoA 3877923 c.585C>T synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoA 3877926 c.582G>C synonymous_variant 0.6 rifampicin
rpoA 3878001 c.507A>G synonymous_variant 0.91 rifampicin Not assoc w R - Interim
rpoA 3878022 c.486T>C synonymous_variant 0.8 rifampicin
rpoA 3878028 c.480G>C synonymous_variant 0.73 rifampicin
rpoA 3878031 c.477T>C synonymous_variant 0.73 rifampicin
rpoA 3878040 c.468T>C synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoA 3878055 c.453A>G synonymous_variant 0.67 rifampicin
rpoA 3878058 c.450G>T synonymous_variant 0.57 rifampicin
rpoA 3878061 c.447G>C synonymous_variant 0.54 rifampicin
rpoA 3878067 c.441C>G synonymous_variant 0.54 rifampicin
rpoA 3878070 c.438T>C synonymous_variant 0.5 rifampicin
rpoA 3878076 c.432C>T synonymous_variant 0.53 rifampicin
rpoA 3878094 c.414C>G synonymous_variant 0.46 rifampicin
rpoA 3878130 c.378C>G synonymous_variant 0.55 rifampicin
rpoA 3878247 c.261G>C synonymous_variant 0.57 rifampicin
rpoA 3878271 c.237T>C synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoA 3878313 c.195G>C synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoA 3878809 c.-302T>C upstream_gene_variant 0.43 rifampicin
rpoA 3878824 c.-317G>C upstream_gene_variant 0.44 rifampicin
rpoA 3878833 c.-326C>G upstream_gene_variant 0.47 rifampicin
rpoA 3878836 c.-331_-329delAAGinsTCC upstream_gene_variant 0.47 rifampicin
rpoA 3878853 c.-346G>A upstream_gene_variant 0.62 rifampicin
rpoA 3878909 c.-402A>G upstream_gene_variant 0.65 rifampicin
rpoA 3878914 c.-407T>C upstream_gene_variant 0.63 rifampicin Uncertain significance
rpoA 3878917 c.-410G>A upstream_gene_variant 0.63 rifampicin Uncertain significance
rpoA 3878938 c.-431T>C upstream_gene_variant 0.67 rifampicin
rpoA 3878968 c.-461T>C upstream_gene_variant 0.62 rifampicin Uncertain significance
rpoA 3878976 c.-469A>G upstream_gene_variant 0.58 rifampicin Uncertain significance
rpoA 3879079 c.-572A>G upstream_gene_variant 0.81 rifampicin
rpoA 3879088 c.-581A>C upstream_gene_variant 0.78 rifampicin
rpoA 3879094 c.-587T>C upstream_gene_variant 0.74 rifampicin
rpoA 3879121 c.-614T>G upstream_gene_variant 0.56 rifampicin
rpoA 3879127 c.-620T>C upstream_gene_variant 0.5 rifampicin
rpoA 3879154 c.-647T>C upstream_gene_variant 0.5 rifampicin
rpoA 3879160 c.-653A>G upstream_gene_variant 0.47 rifampicin
clpC1 4038356 c.2349T>C synonymous_variant 0.82 pyrazinamide
clpC1 4038359 c.2346A>G synonymous_variant 0.8 pyrazinamide
clpC1 4038368 c.2337T>C synonymous_variant 0.8 pyrazinamide
clpC1 4038541 c.2164C>T synonymous_variant 0.82 pyrazinamide
clpC1 4038596 c.2109A>G synonymous_variant 0.6 pyrazinamide
clpC1 4038749 c.1956C>G synonymous_variant 0.53 pyrazinamide
clpC1 4038755 c.1950G>T synonymous_variant 0.56 pyrazinamide
clpC1 4038770 c.1935C>T synonymous_variant 0.58 pyrazinamide
clpC1 4038812 c.1893T>C synonymous_variant 0.65 pyrazinamide
clpC1 4038845 c.1860G>C synonymous_variant 0.64 pyrazinamide
clpC1 4038956 c.1749T>C synonymous_variant 0.69 pyrazinamide
clpC1 4038989 c.1716T>C synonymous_variant 0.54 pyrazinamide
clpC1 4038997 c.1708T>C synonymous_variant 0.5 pyrazinamide Not assoc w R - Interim
clpC1 4039004 c.1701C>G synonymous_variant 0.5 pyrazinamide
clpC1 4039022 c.1683A>G synonymous_variant 0.47 pyrazinamide
clpC1 4039169 p.Glu512Asp missense_variant 0.67 pyrazinamide
clpC1 4039172 c.1533A>G synonymous_variant 0.71 pyrazinamide
clpC1 4039178 c.1527G>C synonymous_variant 0.71 pyrazinamide
clpC1 4039183 c.1522T>C synonymous_variant 0.67 pyrazinamide
clpC1 4039186 c.1519C>T synonymous_variant 0.67 pyrazinamide
clpC1 4039226 c.1479T>C synonymous_variant 0.68 pyrazinamide Not assoc w R - Interim
clpC1 4039229 c.1476C>G synonymous_variant 0.71 pyrazinamide
clpC1 4039274 c.1431G>C synonymous_variant 0.62 pyrazinamide Not assoc w R - Interim
clpC1 4039286 c.1419T>C synonymous_variant 0.62 pyrazinamide
clpC1 4039295 c.1410A>C synonymous_variant 0.53 pyrazinamide
clpC1 4039298 c.1407T>C synonymous_variant 0.5 pyrazinamide
clpC1 4039364 c.1341C>G synonymous_variant 0.47 pyrazinamide
clpC1 4039430 c.1275T>C synonymous_variant 0.71 pyrazinamide
clpC1 4039442 c.1263A>G synonymous_variant 0.69 pyrazinamide
clpC1 4039454 c.1251A>G synonymous_variant 0.65 pyrazinamide Not assoc w R - Interim
clpC1 4039463 c.1242C>G synonymous_variant 0.59 pyrazinamide
clpC1 4039466 c.1239T>C synonymous_variant 0.53 pyrazinamide
clpC1 4039469 c.1236T>C synonymous_variant 0.53 pyrazinamide
clpC1 4039481 c.1224T>C synonymous_variant 0.69 pyrazinamide
clpC1 4039484 c.1221T>C synonymous_variant 0.69 pyrazinamide
clpC1 4039517 c.1188C>G synonymous_variant 0.6 pyrazinamide
clpC1 4039790 c.915C>G synonymous_variant 0.43 pyrazinamide
clpC1 4039817 c.888A>C synonymous_variant 0.47 pyrazinamide Not assoc w R - Interim
clpC1 4039820 c.885T>G synonymous_variant 0.5 pyrazinamide
clpC1 4039826 c.879C>G synonymous_variant 0.52 pyrazinamide
clpC1 4039831 c.874T>C synonymous_variant 0.52 pyrazinamide
clpC1 4039850 c.855T>C synonymous_variant 0.5 pyrazinamide
clpC1 4039865 c.840T>C synonymous_variant 0.56 pyrazinamide
clpC1 4039898 c.807C>G synonymous_variant 0.46 pyrazinamide
clpC1 4040105 c.600C>G synonymous_variant 0.53 pyrazinamide
clpC1 4040147 c.558A>G synonymous_variant 0.44 pyrazinamide Not assoc w R - Interim
clpC1 4040162 c.543G>C synonymous_variant 0.44 pyrazinamide Not assoc w R - Interim
clpC1 4040165 c.540G>C synonymous_variant 0.42 pyrazinamide
clpC1 4040171 c.534C>G synonymous_variant 0.42 pyrazinamide
clpC1 4040431 c.274T>C synonymous_variant 0.4 pyrazinamide
clpC1 4040444 c.261C>T synonymous_variant 0.4 pyrazinamide
clpC1 4040450 c.255A>G synonymous_variant 0.35 pyrazinamide Not assoc w R - Interim
clpC1 4040459 c.246C>G synonymous_variant 0.44 pyrazinamide
clpC1 4040465 c.240T>C synonymous_variant 0.44 pyrazinamide
clpC1 4040471 c.234T>C synonymous_variant 0.47 pyrazinamide Not assoc w R - Interim
clpC1 4040477 c.228G>C synonymous_variant 0.47 pyrazinamide
clpC1 4040480 c.225T>G synonymous_variant 0.47 pyrazinamide
panD 4044954 c.-674_-673delCCinsAT upstream_gene_variant 0.47 pyrazinamide
panD 4044980 c.-699A>G upstream_gene_variant 0.57 pyrazinamide
panD 4044983 c.-702G>T upstream_gene_variant 0.57 pyrazinamide
panD 4044989 c.-708T>C upstream_gene_variant 0.57 pyrazinamide
panD 4045000 c.-719A>C upstream_gene_variant 0.57 pyrazinamide
panD 4045001 c.-720G>C upstream_gene_variant 0.57 pyrazinamide
panD 4045019 c.-738G>C upstream_gene_variant 0.6 pyrazinamide
embC 4240669 c.807G>C synonymous_variant 0.58 ethambutol
embC 4240671 p.Thr270Ile missense_variant 0.58 ethambutol Not assoc w R
embC 4240677 p.Gly272Ala missense_variant 0.58 ethambutol
embC 4240685 p.Thr275Ala missense_variant 0.58 ethambutol
embC 4240693 c.831T>G synonymous_variant 0.67 ethambutol
embC 4240699 c.837C>G synonymous_variant 0.71 ethambutol Not assoc w R - Interim
embC 4240726 c.864G>C synonymous_variant 0.64 ethambutol Not assoc w R - Interim
embC 4240780 c.918T>C synonymous_variant 0.43 ethambutol
embC 4240783 c.921G>C synonymous_variant 0.39 ethambutol
embC 4240789 c.927T>C synonymous_variant 0.33 ethambutol
embC 4240819 c.957A>G synonymous_variant 0.33 ethambutol
embC 4241089 c.1227C>G synonymous_variant 0.5 ethambutol
embC 4241140 c.1278A>G synonymous_variant 0.64 ethambutol Not assoc w R - Interim
embC 4241146 c.1284C>G synonymous_variant 0.62 ethambutol
embC 4241158 c.1296T>C synonymous_variant 0.71 ethambutol
embC 4241161 c.1299C>G synonymous_variant 0.69 ethambutol Not assoc w R - Interim
embC 4241162 c.1300T>C synonymous_variant 0.69 ethambutol
embC 4241170 c.1308G>C synonymous_variant 0.67 ethambutol
embC 4241173 c.1311C>T synonymous_variant 0.73 ethambutol
embC 4241203 c.1341T>C synonymous_variant 0.62 ethambutol
embC 4241206 c.1344G>C synonymous_variant 0.62 ethambutol Not assoc w R - Interim
embC 4241218 c.1356G>C synonymous_variant 0.58 ethambutol
embA 4245137 c.1905T>C synonymous_variant 0.92 ethambutol
embA 4245146 c.1914G>A synonymous_variant 0.92 ethambutol
embA 4245149 c.1917C>G synonymous_variant 0.91 ethambutol
embA 4245153 p.Ile641Val missense_variant 0.83 ethambutol
embA 4245182 c.1950T>C synonymous_variant 0.81 ethambutol
embA 4245189 c.1957C>T synonymous_variant 0.81 ethambutol
embA 4245198 p.Leu656Ile missense_variant 0.8 ethambutol
embA 4245222 p.Tyr664Gln missense_variant 0.8 ethambutol
embA 4245248 c.2016G>C synonymous_variant 0.69 ethambutol
embA 4245257 c.2025A>G synonymous_variant 0.75 ethambutol
embA 4246329 p.Thr1033Ala missense_variant 0.57 ethambutol
embB 4246349 c.-165C>G upstream_gene_variant 0.54 ethambutol
embB 4247470 c.957T>C synonymous_variant 0.4 ethambutol
embB 4247491 c.978G>C synonymous_variant 0.6 ethambutol
embB 4247497 c.984T>C synonymous_variant 0.62 ethambutol
embB 4247512 c.999T>C synonymous_variant 0.62 ethambutol
embB 4247539 c.1026T>C synonymous_variant 0.75 ethambutol
embB 4247554 c.1041T>C synonymous_variant 0.8 ethambutol
embB 4247773 c.1260G>A synonymous_variant 0.62 ethambutol
embB 4247776 c.1263G>T synonymous_variant 0.64 ethambutol
embB 4247797 c.1284C>G synonymous_variant 0.73 ethambutol
embB 4247800 c.1287A>T synonymous_variant 0.6 ethambutol
embB 4247803 c.1290G>C synonymous_variant 0.6 ethambutol
embB 4247815 c.1302C>G synonymous_variant 0.64 ethambutol
embB 4247819 p.Val436Ile missense_variant 0.64 ethambutol Uncertain significance
embB 4247830 c.1317A>G synonymous_variant 0.67 ethambutol Not assoc w R - Interim
embB 4247836 c.1323A>G synonymous_variant 0.64 ethambutol Not assoc w R - Interim
embB 4247839 c.1326G>C synonymous_variant 0.64 ethambutol Not assoc w R - Interim
embB 4247905 c.1392G>C synonymous_variant 0.38 ethambutol Not assoc w R - Interim
embB 4248097 c.1584C>G synonymous_variant 0.64 ethambutol
embB 4248130 c.1617G>C synonymous_variant 0.57 ethambutol
embB 4248172 c.1659G>C synonymous_variant 0.67 ethambutol
embB 4248199 c.1686A>G synonymous_variant 0.55 ethambutol
embB 4248200 p.Ile563Val missense_variant 0.55 ethambutol
embB 4248205 c.1692C>G synonymous_variant 0.55 ethambutol
embB 4248206 p.Ser565Gly missense_variant 0.5 ethambutol Uncertain significance
embB 4248304 c.1791G>C synonymous_variant 0.44 ethambutol
embB 4248316 c.1803C>G synonymous_variant 0.47 ethambutol
embB 4248319 c.1806A>G synonymous_variant 0.47 ethambutol
aftB 4268138 c.699A>C synonymous_variant 0.37 ethambutol Not assoc w R - Interim
aftB 4268144 c.693T>C synonymous_variant 0.39 ethambutol
aftB 4269179 c.-343C>A upstream_gene_variant 0.73 ethambutol
aftB 4269183 c.-347T>C upstream_gene_variant 0.75 ethambutol
aftB 4269186 c.-350C>G upstream_gene_variant 0.75 ethambutol
aftB 4269201 c.-365A>G upstream_gene_variant 0.73 ethambutol
aftB 4269206 c.-370C>T upstream_gene_variant 0.8 ethambutol
ubiA 4269220 p.Ala205Lys missense_variant 0.8 ethambutol
ubiA 4269222 c.612T>C synonymous_variant 0.8 ethambutol Not assoc w R - Interim
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 kanamycin
capreomycin
amikacin