TB-Profiler result

Run: SRR5709967
Summary

Run ID: SRR5709967

Sample name:

Date: 2024-04-15T20:10:10.098768

Number of reads: 1293017

Percentage reads mapped: 82.61

Median coverage: 37.0

Strain: lineage2.2.1

Spoligotype:

Drug-resistance: MDR-TB

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage2 East-Asian RD105 0.95
lineage2.2.1 East-Asian (Beijing) RD105;RD207;RD181 0.97
lineage2.2 East-Asian (Beijing) RD105;RD207 0.98
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin rpoB p.Asp435Val Assoc w R
c.1327_1329delTTGinsCC Assoc w R - Interim Expert rule: Non-silent variants in RRDR of rpoB
isoniazid katG p.Ser315Thr Assoc w R High-level resistance
ethambutol embB p.Gln497Pro Uncertain significance Mutation from literature
pyrazinamide
streptomycin rpsL p.Lys43Arg Assoc w R
rrs n.462C>T Uncertain significance Mutation from literature
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide ethA c.639_640delGT Assoc w R
clofazimine
para-aminosalicylic_acid
delamanid fbiC c.859_861delATCinsGG Assoc w R - Interim Confers DLM-PMD cross-resistance
c.1039_1041delGTTinsAC Assoc w R - Interim Confers DLM-PMD cross-resistance
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
rpoB 761110 p.Asp435Val missense_variant 0.67 rifampicin Assoc w R
rpoB 761133 c.1327_1329delTTGinsCC frameshift_variant&missense_variant 0.31 rifampicin Assoc w R - Interim Expert rule: Non-silent variants in RRDR of rpoB
rpsL 781687 p.Lys43Arg missense_variant 0.7 streptomycin Assoc w R
fbiC 1303789 c.859_861delATCinsGG frameshift_variant&missense_variant 0.19 delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
fbiC 1303969 c.1039_1041delGTTinsAC frameshift_variant&missense_variant 0.17 delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
rrs 1472307 n.462C>T non_coding_transcript_exon_variant 0.19 streptomycin Uncertain significance Mutation from literature
katG 2155168 p.Ser315Thr missense_variant 0.96 isoniazid Assoc w R High-level resistance
embB 4248003 p.Gln497Pro missense_variant 0.91 ethambutol Uncertain significance Mutation from literature
ethA 4326833 c.639_640delGT frameshift_variant 1.0 ethionamide Assoc w R
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
dnaA 741 c.741T>C synonymous_variant 0.18 isoniazid Not assoc w R - Interim
dnaA 1204 c.1204C>T synonymous_variant 0.17 isoniazid
dnaA 1220 p.Asn407Ser missense_variant 0.19 isoniazid
dnaA 1230 c.1230A>G synonymous_variant 0.17 isoniazid
gyrB 6209 c.970C>T synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrB 6217 c.978G>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrB 6223 c.984G>C synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6242 p.Arg335Lys missense_variant 0.18 levofloxacin
moxifloxacin
gyrB 6250 c.1011A>G synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6253 c.1014G>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrB 6307 c.1068T>G synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6700 c.-602T>C upstream_gene_variant 0.17 levofloxacin
moxifloxacin
gyrA 6778 c.-524C>T upstream_gene_variant 0.17 levofloxacin
moxifloxacin
gyrB 6793 c.1554T>C synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6797 p.Gly520Thr missense_variant 0.17 levofloxacin
moxifloxacin
gyrB 6824 c.1585C>T synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6841 c.1602T>C synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6844 c.-458T>G upstream_gene_variant 0.16 levofloxacin
moxifloxacin
gyrB 6856 c.1617T>C synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6919 c.1680T>C synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6925 c.-377T>C upstream_gene_variant 0.18 levofloxacin
moxifloxacin
gyrA 6931 c.-371A>C upstream_gene_variant 0.16 levofloxacin
moxifloxacin
gyrB 6937 c.1698G>A synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6967 c.-335T>C upstream_gene_variant 0.17 levofloxacin
moxifloxacin
gyrA 6970 c.-332C>T upstream_gene_variant 0.17 levofloxacin
moxifloxacin
gyrA 7000 c.-302C>G upstream_gene_variant 0.2 levofloxacin
moxifloxacin
gyrA 7006 c.-296T>G upstream_gene_variant 0.2 levofloxacin
moxifloxacin
gyrB 7012 c.1773G>C synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7018 c.-284G>C upstream_gene_variant 0.17 levofloxacin
moxifloxacin
gyrA 7021 c.-281G>C upstream_gene_variant 0.17 levofloxacin
moxifloxacin
gyrA 7033 c.-269G>C upstream_gene_variant 0.16 levofloxacin
moxifloxacin
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7694 c.393A>G synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 7697 c.396C>G synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 7710 c.409T>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 7715 c.414G>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 7728 c.427_429delAGGinsCC frameshift_variant&missense_variant 0.23 levofloxacin
moxifloxacin
gyrA 7760 c.459C>T synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 7763 c.462T>C synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8078 c.777A>G synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8090 c.789C>G synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8096 c.795T>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8099 c.798T>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8174 c.873C>G synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8177 c.876A>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8198 c.897T>C synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8207 c.906T>C synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 8219 c.918T>C synonymous_variant 0.28 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8225 c.924T>C synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrA 8234 c.933T>G synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8235 c.934_936delTTAinsCG frameshift_variant&missense_variant 0.26 levofloxacin
moxifloxacin
gyrA 8253 p.Ile318Leu missense_variant 0.27 levofloxacin
moxifloxacin
gyrA 8264 c.963T>C synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 8267 c.966G>C synonymous_variant 0.29 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8270 c.969G>C synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 8283 c.982_984delATCinsCG frameshift_variant&missense_variant 0.26 levofloxacin
moxifloxacin
gyrA 8288 c.987T>C synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8294 c.993T>C synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8324 c.1023T>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8339 c.1038A>G synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8342 c.1041G>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8375 c.1074G>C synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 8391 c.1090_1092delTATinsCC frameshift_variant&missense_variant 0.17 levofloxacin
moxifloxacin
gyrA 8399 c.1098T>C synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8414 c.1113C>T synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8420 c.1119T>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8423 c.1122G>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8442 c.1141C>T synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8453 c.1152A>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8462 c.1161A>G synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8471 c.1170T>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8480 c.1179C>T synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8486 c.1185T>C synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8489 c.1188A>G synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8498 c.1197C>T synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 8504 c.1203G>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
fgd1 490827 c.45C>T synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fgd1 490833 c.51G>C synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fgd1 490842 c.60C>G synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fgd1 490851 c.69A>C synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fgd1 490887 c.105G>C synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fgd1 490902 c.120T>C synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fgd1 490905 c.123T>C synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fgd1 490911 c.129T>G synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fgd1 490917 c.135C>A synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fgd1 490921 p.Gln47Glu missense_variant 0.22 clofazimine
pretomanid
delamanid
fgd1 490932 c.150T>C synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fgd1 490948 p.Ser56Ala missense_variant 0.18 clofazimine
pretomanid
delamanid
fgd1 491232 c.450T>C synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fgd1 491241 p.Asp153Glu missense_variant 0.23 clofazimine
pretomanid
delamanid
fgd1 491244 c.462T>C synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fgd1 491259 c.477T>C synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fgd1 491286 c.504G>C synonymous_variant 0.23 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fgd1 491292 c.510G>C synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fgd1 491295 c.513C>G synonymous_variant 0.24 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fgd1 491296 p.Val172Ile missense_variant 0.24 clofazimine
pretomanid
delamanid
fgd1 491742 c.960T>C synonymous_variant 1.0 clofazimine Not assoc w R
pretomanid
delamanid Not assoc w R - Interim
mshA 575587 c.240C>A synonymous_variant 0.28 ethionamide
isoniazid
mshA 575590 c.243T>C synonymous_variant 0.29 ethionamide
isoniazid
mshA 575593 c.246G>C synonymous_variant 0.29 ethionamide
isoniazid
mshA 575623 c.276C>G synonymous_variant 0.29 ethionamide
isoniazid
mshA 575629 c.282A>C synonymous_variant 0.22 ethionamide
isoniazid
mshA 575635 c.288A>C synonymous_variant 0.22 ethionamide
isoniazid Not assoc w R - Interim
mshA 575638 c.291T>C synonymous_variant 0.21 ethionamide
isoniazid
mshA 575641 c.294A>G synonymous_variant 0.18 ethionamide
isoniazid
mshA 575648 p.Val101Gln missense_variant 0.23 ethionamide
isoniazid
mshA 575659 c.312A>G synonymous_variant 0.25 ethionamide
isoniazid
mshA 575665 c.318G>C synonymous_variant 0.24 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
mshA 575689 c.342G>C synonymous_variant 0.33 ethionamide
isoniazid
mshA 575695 c.348C>G synonymous_variant 0.32 ethionamide
isoniazid Not assoc w R - Interim
mshA 575704 c.357T>C synonymous_variant 0.32 ethionamide
isoniazid
mshA 575705 c.358T>C synonymous_variant 0.32 ethionamide
isoniazid
mshA 575713 c.366G>A synonymous_variant 0.31 ethionamide
isoniazid
mshA 575719 c.372C>T synonymous_variant 0.31 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
mshA 575734 c.387T>G synonymous_variant 0.31 ethionamide
isoniazid
mshA 575737 c.390T>C synonymous_variant 0.32 ethionamide
isoniazid
mshA 575746 c.399C>G synonymous_variant 0.33 ethionamide
isoniazid
mshA 575752 c.405G>A synonymous_variant 0.34 ethionamide
isoniazid Not assoc w R - Interim
mshA 575767 c.420G>A synonymous_variant 0.35 ethionamide
isoniazid
mshA 575771 p.Val142Ser missense_variant 0.35 ethionamide
isoniazid
mshA 575779 c.432A>G synonymous_variant 0.39 ethionamide
isoniazid
mshA 575821 c.474G>C synonymous_variant 0.39 ethionamide
isoniazid
mshA 575864 c.517T>C synonymous_variant 0.23 ethionamide
isoniazid
mshA 575907 p.Ala187Val missense_variant 0.94 ethionamide Not assoc w R
isoniazid Not assoc w R
ccsA 620625 p.Ile245Met missense_variant 1.0 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Uncertain significance
Rv0565c 657081 c.390G>A synonymous_variant 1.0 ethionamide Not assoc w R - Interim
Rv0565c 657142 p.Arg110His missense_variant 1.0 ethionamide Uncertain significance
nusG 734457 c.204C>G synonymous_variant 0.24 rifampicin
nusG 734472 c.219T>C synonymous_variant 0.26 rifampicin
nusG 734475 c.222T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
nusG 734481 c.228C>G synonymous_variant 0.29 rifampicin
nusG 734499 c.246G>C synonymous_variant 0.28 rifampicin
nusG 734532 c.279A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
nusG 734541 c.288A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
nusG 734559 c.306T>C synonymous_variant 0.24 rifampicin
nusG 734580 c.327T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
nusG 734625 c.372T>C synonymous_variant 0.16 rifampicin
nusG 734820 c.567A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
nusG 734823 c.570G>A synonymous_variant 0.17 rifampicin
nusG 734826 c.573A>G synonymous_variant 0.17 rifampicin
nusG 734829 c.576C>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
nusG 734832 c.579C>G synonymous_variant 0.18 rifampicin
nusG 734841 c.588G>A synonymous_variant 0.17 rifampicin
nusG 734847 c.594T>C synonymous_variant 0.17 rifampicin
nusG 734853 c.600A>C synonymous_variant 0.17 rifampicin
nusG 734854 c.601T>C synonymous_variant 0.17 rifampicin
rpoB 760101 c.295T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760106 c.300G>T synonymous_variant 0.19 rifampicin
rpoB 760112 c.306T>C synonymous_variant 0.2 rifampicin
rpoB 760118 c.312T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760121 c.315T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760130 p.Asp108Glu missense_variant 0.2 rifampicin Uncertain significance
rpoB 760139 c.333A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760142 c.336C>G synonymous_variant 0.22 rifampicin
rpoB 760181 c.375T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 760184 c.378A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760196 c.390C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760223 c.417T>C synonymous_variant 0.23 rifampicin
rpoB 760235 c.429T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760283 c.477G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760328 c.522G>C synonymous_variant 0.24 rifampicin
rpoB 760331 c.525G>C synonymous_variant 0.25 rifampicin
rpoB 760337 c.531C>G synonymous_variant 0.24 rifampicin
rpoB 760340 c.534G>C synonymous_variant 0.24 rifampicin
rpoB 760361 c.555T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760376 p.Asp190Glu missense_variant 0.23 rifampicin Uncertain significance
rpoB 760406 c.600G>C synonymous_variant 0.26 rifampicin
rpoB 760418 c.612G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760424 c.618C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 760430 c.624T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760475 c.669A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 760481 c.675G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760484 c.678A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760522 p.Ser239Asn missense_variant 0.23 rifampicin Uncertain significance
rpoB 760547 c.741G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760563 p.Arg253Met missense_variant 0.19 rifampicin Uncertain significance
rpoB 760591 p.Val262Ala missense_variant 0.2 rifampicin
rpoB 760611 c.805T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760634 c.828T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760683 c.877T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 760718 c.912C>G synonymous_variant 0.28 rifampicin
rpoB 760721 c.915C>G synonymous_variant 0.28 rifampicin
rpoB 760724 c.918T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 760730 c.924T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 760751 c.945G>C synonymous_variant 0.26 rifampicin
rpoB 760757 c.951T>C synonymous_variant 0.25 rifampicin
rpoB 760759 p.Val318Ala missense_variant 0.25 rifampicin
rpoB 760763 c.957C>T synonymous_variant 0.25 rifampicin
rpoB 760769 c.963C>G synonymous_variant 0.23 rifampicin
rpoB 760775 c.969G>C synonymous_variant 0.21 rifampicin
rpoB 760776 c.970_972delTCGinsAGC synonymous_variant 0.21 rifampicin
rpoB 760793 c.987A>G synonymous_variant 0.18 rifampicin
rpoB 760805 c.999G>C synonymous_variant 0.17 rifampicin
rpoB 760817 c.1011A>G synonymous_variant 0.17 rifampicin
rpoB 760820 c.1014T>C synonymous_variant 0.18 rifampicin
rpoB 760826 c.1020C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760835 c.1029C>T synonymous_variant 0.17 rifampicin
rpoB 760845 p.Thr347Pro missense_variant 0.19 rifampicin
rpoB 760886 c.1080A>G synonymous_variant 0.2 rifampicin
rpoB 760919 c.1113C>G synonymous_variant 0.26 rifampicin
rpoB 760925 c.1119T>C synonymous_variant 0.26 rifampicin
rpoB 760928 c.1122G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 760934 c.1128C>T synonymous_variant 0.32 rifampicin
rpoB 760946 c.1140A>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 760970 c.1164G>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 760982 c.1176G>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 760985 c.1179G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 760991 c.1185G>C synonymous_variant 0.33 rifampicin
rpoB 761015 c.1209G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 761021 c.1215G>C synonymous_variant 0.33 rifampicin
rpoB 761027 c.1221A>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 761036 c.1230G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 761037 c.1231T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 761051 c.1245G>T synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 761054 c.1248G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 761057 c.1251G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 761060 c.1254C>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 761063 c.1257C>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 761097 c.1291_1292delAGinsTC synonymous_variant 0.28 rifampicin
rpoB 761102 c.1296A>G synonymous_variant 0.29 rifampicin
rpoB 761150 c.1344A>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 761165 c.1359G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 761168 c.1362C>G synonymous_variant 0.24 rifampicin
rpoB 761171 c.1365C>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 761180 c.1374A>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 761183 c.1377T>G synonymous_variant 0.27 rifampicin
rpoB 761189 c.1383T>G synonymous_variant 0.26 rifampicin
rpoB 761222 c.1416G>C synonymous_variant 0.25 rifampicin
rpoB 761249 c.1443A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 761255 c.1449T>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 761261 c.1455G>T synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 761306 c.1500C>G synonymous_variant 0.19 rifampicin
rpoB 761570 c.1764T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761573 c.1767C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761579 c.1773G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761606 c.1800C>G synonymous_variant 0.22 rifampicin
rpoB 761612 c.1806G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 761615 c.1809A>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 761636 c.1830G>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 761645 c.1839C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761648 c.1842T>C synonymous_variant 0.18 rifampicin
rpoB 761657 c.1851C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761675 c.1869G>C synonymous_variant 0.16 rifampicin
rpoB 761687 c.1881C>T synonymous_variant 0.15 rifampicin
rpoB 762114 p.Ile770Val missense_variant 0.17 rifampicin Uncertain significance
rpoB 762131 c.2325C>G synonymous_variant 0.21 rifampicin
rpoB 762140 c.2334G>C synonymous_variant 0.26 rifampicin
rpoB 762143 c.2337T>C synonymous_variant 0.26 rifampicin
rpoB 762149 c.2343G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 762167 c.2361T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 762176 c.2370T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 762185 c.2379G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 762254 c.2448T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 762266 c.2460T>C synonymous_variant 0.19 rifampicin
rpoB 762284 c.2478G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 762293 c.2487T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 762317 c.2511A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 762329 c.2523G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 762338 c.2532T>C synonymous_variant 0.22 rifampicin
rpoB 762347 c.2541T>C synonymous_variant 0.2 rifampicin
rpoB 762362 p.Glu852Asp missense_variant 0.2 rifampicin
rpoB 762369 c.2563T>C synonymous_variant 0.18 rifampicin
rpoC 762395 c.-975G>C upstream_gene_variant 0.17 rifampicin
rpoC 762398 c.-972T>C upstream_gene_variant 0.18 rifampicin
rpoC 762401 c.-969G>C upstream_gene_variant 0.18 rifampicin
rpoB 762404 c.2598T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 762410 c.-960T>C upstream_gene_variant 0.18 rifampicin
rpoB 762416 c.2610A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 762443 c.-927G>C upstream_gene_variant 0.17 rifampicin
rpoB 762470 c.2664G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>C synonymous_variant 0.7 rifampicin Not assoc w R
rpoB 763136 c.3330C>T synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 763148 c.-222G>C upstream_gene_variant 0.25 rifampicin
rpoC 763468 c.99G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 763486 c.117T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 763528 c.159G>A synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 763594 c.225C>T synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 763633 c.264T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 763636 c.267T>C synonymous_variant 0.26 rifampicin
rpoC 763642 c.273G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 763658 c.289_291delCTTinsTG frameshift_variant&missense_variant 0.26 rifampicin
rpoC 763675 c.306C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 763696 c.327T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 763702 c.333C>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 763801 c.432C>G synonymous_variant 0.18 rifampicin
rpoC 763807 c.438T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 763819 c.450G>C synonymous_variant 0.17 rifampicin
rpoC 763835 p.Ala156Met missense_variant 0.15 rifampicin
rpoC 763858 c.489A>G synonymous_variant 0.21 rifampicin
rpoC 763872 p.Gly168Ala missense_variant 0.2 rifampicin
rpoC 763876 p.Glu169Asp missense_variant 0.22 rifampicin
rpoC 763879 c.510A>G synonymous_variant 0.23 rifampicin
rpoC 763888 c.519G>C synonymous_variant 0.22 rifampicin
rpoC 763891 c.522G>C synonymous_variant 0.23 rifampicin
rpoC 763894 c.525A>G synonymous_variant 0.23 rifampicin
rpoC 763903 c.534G>A synonymous_variant 0.23 rifampicin
rpoC 763945 c.576T>C synonymous_variant 0.2 rifampicin
rpoC 763960 c.591T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 763967 p.Gly200Ser missense_variant 0.18 rifampicin
rpoC 763978 c.609C>G synonymous_variant 0.22 rifampicin
rpoC 763996 c.627T>C synonymous_variant 0.24 rifampicin
rpoC 764005 c.636G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 764011 c.642T>C synonymous_variant 0.25 rifampicin
rpoC 764024 c.655T>C synonymous_variant 0.28 rifampicin
rpoC 764040 p.Ser224Asn missense_variant 0.3 rifampicin
rpoC 764044 c.675T>C synonymous_variant 0.31 rifampicin
rpoC 764059 c.690G>C synonymous_variant 0.32 rifampicin
rpoC 764083 c.714A>G synonymous_variant 0.32 rifampicin
rpoC 764098 c.729A>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 764101 c.732C>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 764116 c.747C>T synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 764131 c.762T>C synonymous_variant 0.29 rifampicin
rpoC 764161 c.792G>C synonymous_variant 0.23 rifampicin
rpoC 764188 c.819A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764195 p.Ser276Gln missense_variant 0.17 rifampicin
rpoC 764203 c.834G>T synonymous_variant 0.16 rifampicin
rpoC 764257 c.888G>C synonymous_variant 0.23 rifampicin
rpoC 764266 c.897T>C synonymous_variant 0.24 rifampicin
rpoC 764269 c.900G>C synonymous_variant 0.23 rifampicin
rpoC 764380 c.1011G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764381 c.1012_1013delTCinsAG synonymous_variant 0.2 rifampicin
rpoC 764387 c.1018_1020delTTGinsCC frameshift_variant&missense_variant 0.2 rifampicin
rpoC 764431 c.1062G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764434 c.1065A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764461 c.1092A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764497 c.1128A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764521 c.1152T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764536 c.1167G>C synonymous_variant 0.26 rifampicin
rpoC 764539 c.1170C>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 764560 c.1191T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764566 c.1197C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 764573 c.1204_1206delCTTinsTG frameshift_variant&missense_variant 0.2 rifampicin
rpoC 764576 c.1207_1208delTCinsAG synonymous_variant 0.19 rifampicin
rpoC 764581 c.1212T>C synonymous_variant 0.19 rifampicin
rpoC 764626 c.1257C>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764632 c.1263T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764681 c.1312C>T synonymous_variant 0.2 rifampicin
rpoC 764695 c.1326T>C synonymous_variant 0.21 rifampicin
rpoC 764716 c.1347G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764746 c.1377G>C synonymous_variant 0.22 rifampicin
rpoC 764752 c.1383G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764809 c.1440C>T synonymous_variant 0.17 rifampicin Not assoc w R
rpoC 764812 c.1443C>G synonymous_variant 0.17 rifampicin
rpoC 764815 c.1446A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 765404 p.Leu679Val missense_variant 0.18 rifampicin
rpoC 765409 c.2040T>C synonymous_variant 0.17 rifampicin
rpoC 765412 c.2043T>C synonymous_variant 0.17 rifampicin
rpoC 765421 c.2052C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 765451 c.2082C>G synonymous_variant 0.23 rifampicin
rpoC 765452 c.2083_2085delGCCinsTG frameshift_variant&missense_variant 0.21 rifampicin
rpoC 765478 c.2109T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 765499 c.2130C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 765508 c.2139C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 765541 c.2172C>G synonymous_variant 0.2 rifampicin
rpoC 765553 c.2184C>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 765556 c.2187G>C synonymous_variant 0.2 rifampicin
rpoC 765559 c.2190G>C synonymous_variant 0.19 rifampicin
rpoC 765578 c.2209C>T synonymous_variant 0.17 rifampicin
rpoC 765583 c.2214G>T synonymous_variant 0.18 rifampicin
rpoC 765613 p.His748Gln missense_variant 0.17 rifampicin
rpoC 765625 c.2256C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 765628 c.2259G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 765631 p.Asp754Glu missense_variant 0.23 rifampicin
rpoC 765649 c.2280C>T synonymous_variant 0.26 rifampicin
rpoC 765658 c.2289C>T synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 765700 c.2331T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 765734 c.2365T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 765739 c.2370G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 765753 p.Asp795Ala missense_variant 0.21 rifampicin Uncertain significance
rpoC 765772 c.2403C>G synonymous_variant 0.2 rifampicin
rpoC 765784 c.2415C>G synonymous_variant 0.2 rifampicin
rpoC 765796 c.2427C>T synonymous_variant 0.19 rifampicin
rpoC 765811 c.2442T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 765814 c.2445A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 765826 c.2457T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 765835 c.2466C>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 765871 c.2502T>C synonymous_variant 0.2 rifampicin
rpoC 765883 c.2514C>G synonymous_variant 0.22 rifampicin
rpoC 765886 c.2517C>G synonymous_variant 0.21 rifampicin
rpoC 765892 c.2523T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 765928 c.2559C>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 766484 c.3115_3117delGTAinsAC frameshift_variant&missense_variant 0.16 rifampicin
rpoC 766492 c.3123T>C synonymous_variant 0.18 rifampicin
rpoC 766495 c.3126C>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 766528 c.3159T>G synonymous_variant 0.22 rifampicin
rpoC 766543 c.3174C>T synonymous_variant 0.22 rifampicin
rpoC 766573 c.3204T>C synonymous_variant 0.2 rifampicin
rpoC 766607 c.3238_3240delATCinsCG frameshift_variant&missense_variant 0.21 rifampicin
rpoC 766645 c.3276A>G synonymous_variant 0.18 rifampicin
rpoC 766651 c.3282T>C synonymous_variant 0.19 rifampicin
rpoC 766657 c.3288A>G synonymous_variant 0.19 rifampicin
rpoC 766672 c.3303T>C synonymous_variant 0.16 rifampicin
rpoC 766738 c.3369G>T synonymous_variant 0.21 rifampicin
rpoC 766750 c.3381C>G synonymous_variant 0.22 rifampicin
rpoC 766861 c.3492G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 766864 c.3495G>C synonymous_variant 0.19 rifampicin
rpoC 766996 c.3627C>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 767033 c.3664_3666delTCGinsAGT synonymous_variant 0.22 rifampicin
rpoC 767059 c.3690T>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 767062 c.3693C>A synonymous_variant 0.3 rifampicin
rpoC 767074 c.3705T>C synonymous_variant 0.29 rifampicin
mmpL5 775639 p.Ile948Val missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
mmpL5 776100 p.Thr794Ile missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
mmpL5 776182 p.Asp767Asn missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R
mmpS5 779615 c.-710C>G upstream_gene_variant 1.0 clofazimine
bedaquiline
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781682 c.123T>C synonymous_variant 0.29 streptomycin
rpsL 781715 c.156T>C synonymous_variant 0.28 streptomycin
rpsL 781728 c.169T>C synonymous_variant 0.3 streptomycin
rpsL 781736 c.177T>C synonymous_variant 0.31 streptomycin
rpsL 781751 c.192G>C synonymous_variant 0.3 streptomycin
rpsL 781754 c.195G>C synonymous_variant 0.3 streptomycin
rpsL 781760 c.201T>C synonymous_variant 0.27 streptomycin
rpsL 781793 c.234G>C synonymous_variant 0.26 streptomycin
rpsL 781832 c.273T>C synonymous_variant 0.21 streptomycin
rpsL 781841 c.282C>G synonymous_variant 0.21 streptomycin
rpsL 781859 c.300T>C synonymous_variant 0.17 streptomycin Not assoc w R - Interim
rpsL 781868 c.309T>C synonymous_variant 0.17 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.17 streptomycin
rpsL 781898 c.339A>T synonymous_variant 0.17 streptomycin
rpsL 781916 c.357T>C synonymous_variant 0.22 streptomycin
rplC 800612 c.-197A>G upstream_gene_variant 0.24 linezolid
rplC 800618 c.-191T>C upstream_gene_variant 0.25 linezolid
rplC 800648 c.-161A>C upstream_gene_variant 0.24 linezolid
rplC 800654 c.-155T>C upstream_gene_variant 0.24 linezolid
rplC 800693 c.-116A>G upstream_gene_variant 0.21 linezolid
rplC 800703 c.-106T>C upstream_gene_variant 0.21 linezolid
rplC 800715 c.-94A>C upstream_gene_variant 0.18 linezolid
rplC 800720 c.-89T>C upstream_gene_variant 0.19 linezolid
rplC 800723 c.-86C>G upstream_gene_variant 0.19 linezolid
rplC 800771 c.-38C>T upstream_gene_variant 0.13 linezolid
Rv1129c 1254562 c.-28T>C upstream_gene_variant 1.0 moxifloxacin Not assoc w R
levofloxacin Not assoc w R
rifampicin Not assoc w R
isoniazid Not assoc w R
fbiC 1303312 p.Ile128Val missense_variant 1.0 clofazimine
pretomanid
delamanid
fbiC 1303545 c.615A>G synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1303560 c.630G>C synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1303575 c.645G>C synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1303584 c.654C>G synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fbiC 1303590 c.660A>G synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fbiC 1303602 c.672A>G synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fbiC 1303605 c.675C>G synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fbiC 1303608 c.678G>A synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fbiC 1303611 c.681G>C synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fbiC 1303614 c.684C>T synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fbiC 1303617 c.687C>G synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fbiC 1303632 c.702T>G synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1303638 c.708A>G synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1303659 c.729T>C synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1303661 p.Val244Ala missense_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1303674 c.744C>G synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1303686 c.756C>G synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1303695 c.765T>C synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1303701 c.771C>G synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1303708 c.778T>C synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1303722 c.792C>G synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1303728 c.798G>A synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1303731 c.801A>C synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1303732 p.Ser268Ala missense_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1303737 c.807G>A synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1303746 c.816T>C synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1303749 c.819G>C synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1303752 c.822A>G synonymous_variant 0.22 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1303755 c.825T>C synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1303785 c.855G>C synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1303818 c.888C>G synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fbiC 1303836 c.906G>C synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1303854 c.924T>C synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1303860 c.930A>C synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1303884 c.954T>G synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1303911 c.981G>C synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1303914 c.984C>G synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1303920 c.990C>G synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1303923 c.993C>T synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1303929 c.999G>C synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1303932 c.1002G>A synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1303947 c.1017T>C synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1303948 p.Gly340Arg missense_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1303973 p.Gly348Ala missense_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1303995 c.1065C>T synonymous_variant 0.15 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1304008 c.1078T>C synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1304034 c.1104A>G synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1304040 c.1110C>G synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1304046 c.1116C>G synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1304049 c.1119T>G synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1304058 c.1128G>A synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1304059 c.1129C>T synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1304064 c.1134G>C synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1304067 c.1137G>C synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1304097 c.1167G>C synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1304136 c.1206C>T synonymous_variant 0.14 clofazimine
pretomanid
delamanid
sigE 1364784 c.372C>G synonymous_variant 0.18 pyrazinamide
sigE 1364790 c.378T>C synonymous_variant 0.21 pyrazinamide
sigE 1364802 c.390C>A synonymous_variant 0.28 pyrazinamide
sigE 1364811 c.399A>G synonymous_variant 0.22 pyrazinamide
sigE 1364820 c.408A>G synonymous_variant 0.2 pyrazinamide
sigE 1364835 c.423C>G synonymous_variant 0.21 pyrazinamide
sigE 1364838 c.426C>T synonymous_variant 0.22 pyrazinamide
sigE 1364839 c.427T>C synonymous_variant 0.22 pyrazinamide
sigE 1364862 c.450C>G synonymous_variant 0.21 pyrazinamide
sigE 1364865 c.453G>C synonymous_variant 0.2 pyrazinamide
sigE 1364866 c.454_456delGCTinsTG frameshift_variant&missense_variant 0.2 pyrazinamide Uncertain significance
sigE 1364887 c.475_477delTTAinsCG frameshift_variant&missense_variant 0.21 pyrazinamide Uncertain significance
sigE 1364904 p.Asp164Glu missense_variant 0.19 pyrazinamide
Rv1258c 1406760 c.580_581insC frameshift_variant 1.0 streptomycin Uncertain significance
isoniazid Uncertain significance
pyrazinamide Uncertain significance
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474823 n.1166C>T non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1474831 n.1174A>G non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid
rrl 1474991 n.1334T>C non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1475006 n.1349A>T non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid Uncertain significance
inhA 1674382 p.Leu61Ile missense_variant 0.14 ethionamide
isoniazid
inhA 1674507 c.306G>C synonymous_variant 0.26 ethionamide
isoniazid
inhA 1674537 c.336C>G synonymous_variant 0.28 ethionamide
isoniazid
inhA 1674542 p.Ala114Glu missense_variant 0.25 ethionamide
isoniazid
inhA 1674549 c.348G>C synonymous_variant 0.23 ethionamide
isoniazid
inhA 1674555 c.354G>A synonymous_variant 0.19 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
inhA 1674558 c.357C>A synonymous_variant 0.19 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
inhA 1674561 c.360C>T synonymous_variant 0.19 ethionamide
isoniazid
inhA 1674582 c.381T>C synonymous_variant 0.19 ethionamide
isoniazid
inhA 1674585 c.384T>C synonymous_variant 0.19 ethionamide
isoniazid
inhA 1674589 p.Met130Leu missense_variant 0.2 ethionamide
isoniazid
inhA 1674624 c.423A>C synonymous_variant 0.21 ethionamide
isoniazid
inhA 1674627 c.426T>G synonymous_variant 0.2 ethionamide
isoniazid
inhA 1674630 c.429C>G synonymous_variant 0.2 ethionamide
isoniazid
inhA 1674636 c.435C>G synonymous_variant 0.19 ethionamide
isoniazid
inhA 1674654 c.453G>C synonymous_variant 0.19 ethionamide
isoniazid
inhA 1674693 c.492C>G synonymous_variant 0.16 ethionamide
isoniazid
inhA 1674703 c.502T>C synonymous_variant 0.17 ethionamide
isoniazid
rpsA 1833619 c.78A>C synonymous_variant 0.2 pyrazinamide
rpsA 1833661 c.120A>G synonymous_variant 0.23 pyrazinamide
rpsA 1833667 c.126C>G synonymous_variant 0.23 pyrazinamide
rpsA 1833724 c.183C>G synonymous_variant 0.17 pyrazinamide
rpsA 1833727 c.186G>C synonymous_variant 0.16 pyrazinamide
rpsA 1833742 c.201A>G synonymous_variant 0.2 pyrazinamide
rpsA 1833745 c.204G>C synonymous_variant 0.2 pyrazinamide
rpsA 1833787 c.246C>G synonymous_variant 0.21 pyrazinamide
rpsA 1833790 c.249T>A synonymous_variant 0.22 pyrazinamide
rpsA 1833799 c.258C>G synonymous_variant 0.23 pyrazinamide
rpsA 1833811 c.270G>C synonymous_variant 0.21 pyrazinamide
rpsA 1833838 c.297G>C synonymous_variant 0.21 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.19 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.18 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.23 pyrazinamide
rpsA 1833862 c.321G>T synonymous_variant 0.24 pyrazinamide
rpsA 1833874 c.333T>C synonymous_variant 0.24 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.23 pyrazinamide
rpsA 1833940 c.399C>G synonymous_variant 0.24 pyrazinamide
rpsA 1833952 c.411C>A synonymous_variant 0.25 pyrazinamide
rpsA 1833970 c.429G>C synonymous_variant 0.22 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.22 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.22 pyrazinamide
rpsA 1834015 c.474G>C synonymous_variant 0.19 pyrazinamide
rpsA 1834021 c.480C>T synonymous_variant 0.2 pyrazinamide
rpsA 1834177 c.636A>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
rpsA 1834186 c.645C>G synonymous_variant 0.18 pyrazinamide
rpsA 1834189 c.648G>C synonymous_variant 0.19 pyrazinamide
rpsA 1834195 c.654G>C synonymous_variant 0.18 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 0.18 pyrazinamide Not assoc w R - Interim
rpsA 1834366 c.825A>G synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
rpsA 1834375 c.834G>A synonymous_variant 0.18 pyrazinamide
rpsA 1834411 c.870T>C synonymous_variant 0.25 pyrazinamide
rpsA 1834417 c.876G>C synonymous_variant 0.27 pyrazinamide
rpsA 1834423 c.882G>C synonymous_variant 0.26 pyrazinamide
rpsA 1834435 c.894G>C synonymous_variant 0.24 pyrazinamide
rpsA 1834451 c.910T>C synonymous_variant 0.29 pyrazinamide
rpsA 1834465 c.924T>C synonymous_variant 0.32 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.32 pyrazinamide
rpsA 1834474 c.933C>G synonymous_variant 0.33 pyrazinamide
rpsA 1834489 c.948T>C synonymous_variant 0.31 pyrazinamide
rpsA 1834498 c.957C>T synonymous_variant 0.29 pyrazinamide
rpsA 1834528 c.987T>C synonymous_variant 0.32 pyrazinamide
tsnR 1853370 c.-236G>T upstream_gene_variant 0.15 linezolid
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
katG 2154724 p.Arg463Leu missense_variant 1.0 isoniazid Not assoc w R
PPE35 2167926 p.Leu896Ser missense_variant 1.0 pyrazinamide Not assoc w R
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
kasA 2517947 c.-168C>T upstream_gene_variant 0.21 isoniazid
kasA 2518609 p.Met165Ile missense_variant 0.2 isoniazid
kasA 2518621 c.507G>A synonymous_variant 0.24 isoniazid
kasA 2518642 c.528A>G synonymous_variant 0.25 isoniazid
kasA 2518663 c.549T>C synonymous_variant 0.21 isoniazid
kasA 2518672 c.558G>C synonymous_variant 0.21 isoniazid
kasA 2518687 c.573C>T synonymous_variant 0.21 isoniazid
kasA 2518696 c.582C>G synonymous_variant 0.22 isoniazid
kasA 2518702 c.588C>T synonymous_variant 0.22 isoniazid
kasA 2518711 c.597A>G synonymous_variant 0.17 isoniazid
kasA 2518714 c.600A>C synonymous_variant 0.17 isoniazid
kasA 2518717 c.603C>T synonymous_variant 0.18 isoniazid
kasA 2518732 c.618C>G synonymous_variant 0.18 isoniazid
kasA 2518741 c.627G>C synonymous_variant 0.19 isoniazid
kasA 2518783 c.669T>C synonymous_variant 0.19 isoniazid
kasA 2518792 c.678C>G synonymous_variant 0.24 isoniazid
kasA 2518795 c.681C>G synonymous_variant 0.22 isoniazid
kasA 2518816 c.702C>A synonymous_variant 0.27 isoniazid
kasA 2518822 c.708C>G synonymous_variant 0.27 isoniazid
kasA 2518825 c.711T>C synonymous_variant 0.28 isoniazid
kasA 2518855 c.741C>G synonymous_variant 0.25 isoniazid
kasA 2518864 c.750G>C synonymous_variant 0.26 isoniazid
kasA 2518879 c.765A>G synonymous_variant 0.22 isoniazid
kasA 2518885 c.771T>C synonymous_variant 0.2 isoniazid
kasA 2518888 c.774C>T synonymous_variant 0.21 isoniazid
kasA 2518898 c.784T>C synonymous_variant 0.2 isoniazid
kasA 2518906 c.792A>G synonymous_variant 0.18 isoniazid
kasA 2519176 c.1062G>A synonymous_variant 0.16 isoniazid
folC 2747355 p.Val82Ile missense_variant 0.18 para-aminosalicylic_acid
folC 2747359 c.240C>G synonymous_variant 0.18 para-aminosalicylic_acid
folC 2747362 c.237G>C synonymous_variant 0.18 para-aminosalicylic_acid
Rv2477c 2783020 c.1023G>C synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783040 p.Ala335Thr missense_variant 0.16 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
kanamycin Uncertain significance
rifampicin Uncertain significance
amikacin Uncertain significance
Rv2477c 2783062 c.981C>G synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783068 p.Asp325Glu missense_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783077 c.966T>C synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783350 c.693T>C synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783353 c.690T>C synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783359 c.684G>A synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783362 c.681G>C synonymous_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783365 c.678C>T synonymous_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783373 p.Glu224Gln missense_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783395 c.648T>C synonymous_variant 0.31 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783473 c.570A>G synonymous_variant 0.15 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783494 c.549C>G synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783502 c.541T>C synonymous_variant 0.24 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783512 c.531A>G synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783520 c.523T>C synonymous_variant 0.27 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783527 c.516A>G synonymous_variant 0.3 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783548 c.495T>C synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783551 c.492G>A synonymous_variant 0.24 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783563 c.480A>G synonymous_variant 0.33 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783569 c.474C>G synonymous_variant 0.3 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783572 c.471A>G synonymous_variant 0.3 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783578 p.Glu155Asp missense_variant 0.32 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783586 p.Ala153Pro missense_variant 0.34 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783593 c.450T>C synonymous_variant 0.34 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783605 c.438T>C synonymous_variant 0.32 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783611 c.432C>G synonymous_variant 0.33 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783628 p.Ala139Ser missense_variant 0.33 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783629 c.414C>T synonymous_variant 0.33 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783665 c.378A>G synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783683 c.360A>G synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783691 c.352C>T synonymous_variant 0.28 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783700 p.Thr115Ser missense_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783719 c.324A>G synonymous_variant 0.27 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783751 p.Ile98Val missense_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783758 p.Asp95Glu missense_variant 0.27 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783779 c.264T>C synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783794 c.249G>A synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783797 p.Asp82Glu missense_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783815 c.228A>G synonymous_variant 0.27 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783833 c.210G>C synonymous_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783860 p.Asp61Glu missense_variant 0.32 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783863 c.180C>T synonymous_variant 0.27 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783883 c.160T>C synonymous_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783884 c.159T>C synonymous_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783887 c.156C>G synonymous_variant 0.28 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783920 c.123G>C synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783926 c.117C>T synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783941 c.102C>T synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783953 c.90G>A synonymous_variant 0.2 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783962 c.81T>C synonymous_variant 0.18 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783971 c.72G>C synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783980 c.63C>G synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783992 c.51T>C synonymous_variant 0.16 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2784428 c.-386T>C upstream_gene_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2784429 c.-387A>G upstream_gene_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2784432 c.-390A>C upstream_gene_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2784455 c.-413A>C upstream_gene_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2784456 c.-414A>C upstream_gene_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2784472 c.-430C>A upstream_gene_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2784477 c.-435T>C upstream_gene_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2784492 c.-450C>G upstream_gene_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2752c 3066024 c.168T>C synonymous_variant 0.16 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066050 p.Leu48Met missense_variant 0.19 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066054 c.138T>G synonymous_variant 0.18 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066066 c.126T>C synonymous_variant 0.19 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066075 c.117A>G synonymous_variant 0.17 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066087 c.105A>G synonymous_variant 0.16 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
Rv2752c 3066118 p.Asn25Ser missense_variant 0.17 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
thyX 3067293 p.Gln218Arg missense_variant 0.2 para-aminosalicylic_acid
thyX 3067304 c.642A>G synonymous_variant 0.22 para-aminosalicylic_acid
thyX 3067316 c.630A>G synonymous_variant 0.26 para-aminosalicylic_acid
thyX 3067325 c.621A>G synonymous_variant 0.27 para-aminosalicylic_acid
thyX 3067355 c.591A>C synonymous_variant 0.26 para-aminosalicylic_acid
thyX 3067367 c.579G>C synonymous_variant 0.27 para-aminosalicylic_acid
thyX 3067376 c.570G>C synonymous_variant 0.25 para-aminosalicylic_acid
thyX 3067391 c.555G>C synonymous_variant 0.23 para-aminosalicylic_acid
thyX 3067394 c.552G>C synonymous_variant 0.24 para-aminosalicylic_acid
thyX 3067412 c.534C>G synonymous_variant 0.29 para-aminosalicylic_acid
thyX 3067439 c.507A>G synonymous_variant 0.31 para-aminosalicylic_acid
thyX 3067445 c.501C>G synonymous_variant 0.27 para-aminosalicylic_acid
thyX 3067451 c.495G>A synonymous_variant 0.25 para-aminosalicylic_acid
thyX 3067457 c.489C>G synonymous_variant 0.24 para-aminosalicylic_acid
thyX 3067463 c.481_483delATCinsGA frameshift_variant&missense_variant 0.22 para-aminosalicylic_acid
thyX 3067466 c.480G>C synonymous_variant 0.22 para-aminosalicylic_acid
thyX 3067470 p.Asn159Ser missense_variant 0.21 para-aminosalicylic_acid
thyX 3067493 c.453A>G synonymous_variant 0.22 para-aminosalicylic_acid
thyX 3067500 p.Lys149Arg missense_variant 0.22 para-aminosalicylic_acid
thyX 3067685 c.261A>G synonymous_variant 0.17 para-aminosalicylic_acid
thyX 3067688 c.258G>C synonymous_variant 0.18 para-aminosalicylic_acid
thyX 3067694 c.252G>C synonymous_variant 0.18 para-aminosalicylic_acid
thyX 3067718 c.228C>G synonymous_variant 0.18 para-aminosalicylic_acid
thyX 3067721 c.225T>C synonymous_variant 0.18 para-aminosalicylic_acid
thyX 3067724 c.222G>A synonymous_variant 0.18 para-aminosalicylic_acid
thyX 3067727 c.219A>C synonymous_variant 0.18 para-aminosalicylic_acid
thyX 3067742 c.204A>C synonymous_variant 0.16 para-aminosalicylic_acid
thyX 3067765 p.Leu61Ile missense_variant 0.16 para-aminosalicylic_acid
thyX 3067781 c.165C>G synonymous_variant 0.21 para-aminosalicylic_acid
thyX 3067787 c.159G>A synonymous_variant 0.19 para-aminosalicylic_acid
thyX 3067793 c.153T>C synonymous_variant 0.19 para-aminosalicylic_acid
thyX 3067799 c.147G>A synonymous_variant 0.18 para-aminosalicylic_acid
thyX 3067802 c.144C>G synonymous_variant 0.19 para-aminosalicylic_acid
thyA 3073872 c.598_600delATCinsGG frameshift_variant&missense_variant 0.17 para-aminosalicylic_acid
thyA 3073878 c.594G>A synonymous_variant 0.17 para-aminosalicylic_acid
thyA 3073892 c.580T>C synonymous_variant 0.22 para-aminosalicylic_acid
thyA 3073893 c.579C>G synonymous_variant 0.22 para-aminosalicylic_acid
thyA 3073899 c.573G>A synonymous_variant 0.24 para-aminosalicylic_acid
thyA 3073925 c.547T>C synonymous_variant 0.25 para-aminosalicylic_acid
thyA 3073926 c.546G>C synonymous_variant 0.25 para-aminosalicylic_acid
thyA 3073929 c.543T>C synonymous_variant 0.25 para-aminosalicylic_acid
thyA 3073953 c.519T>C synonymous_variant 0.26 para-aminosalicylic_acid
thyA 3073977 c.495A>G synonymous_variant 0.27 para-aminosalicylic_acid
thyA 3073989 c.483T>C synonymous_variant 0.26 para-aminosalicylic_acid
thyA 3074001 c.471C>G synonymous_variant 0.17 para-aminosalicylic_acid
thyA 3074004 c.468T>C synonymous_variant 0.17 para-aminosalicylic_acid
thyA 3074010 c.462C>G synonymous_variant 0.17 para-aminosalicylic_acid
thyA 3074031 c.441T>C synonymous_variant 0.18 para-aminosalicylic_acid
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
Rv3236c 3612813 p.Thr102Ala missense_variant 1.0 pyrazinamide Not assoc w R - Interim
mtrB 3625065 p.Met517Leu missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
mtrB 3625569 c.1045T>C synonymous_variant 0.21 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625572 p.Thr348Ser missense_variant 0.21 bedaquiline
rifampicin
lpqB 3625579 c.-669A>G upstream_gene_variant 0.23 bedaquiline
rifampicin
mtrB 3625592 p.Ser341Asn missense_variant 0.26 bedaquiline
rifampicin
lpqB 3625594 c.-684T>C upstream_gene_variant 0.25 bedaquiline
rifampicin
lpqB 3625602 c.-692T>C upstream_gene_variant 0.24 bedaquiline
rifampicin
lpqB 3625606 c.-696C>T upstream_gene_variant 0.25 bedaquiline
rifampicin
lpqB 3625612 c.-702G>C upstream_gene_variant 0.25 bedaquiline
rifampicin
mtrB 3625616 p.Arg333Ala missense_variant 0.26 bedaquiline
rifampicin
lpqB 3625624 c.-714C>G upstream_gene_variant 0.28 bedaquiline
rifampicin
lpqB 3625627 c.-717C>T upstream_gene_variant 0.28 bedaquiline
rifampicin
lpqB 3625648 c.-738T>C upstream_gene_variant 0.24 bedaquiline
rifampicin
mtrB 3625656 c.958T>C synonymous_variant 0.25 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
lpqB 3625663 c.-753G>C upstream_gene_variant 0.22 bedaquiline
rifampicin
lpqB 3625669 c.-759G>C upstream_gene_variant 0.26 bedaquiline
rifampicin
lpqB 3625687 c.-777G>C upstream_gene_variant 0.24 bedaquiline
rifampicin
lpqB 3625690 c.-780T>C upstream_gene_variant 0.29 bedaquiline
rifampicin
lpqB 3625696 c.-786A>G upstream_gene_variant 0.24 bedaquiline
rifampicin
mtrB 3625705 c.909C>G synonymous_variant 0.26 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625714 c.-804C>T upstream_gene_variant 0.32 bedaquiline
rifampicin
mtrB 3625720 c.894G>C synonymous_variant 0.27 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625729 c.885A>G synonymous_variant 0.29 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625735 c.879C>A synonymous_variant 0.29 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625750 c.864G>A synonymous_variant 0.27 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625755 p.Ala287Thr missense_variant 0.28 bedaquiline
rifampicin Uncertain significance
mtrB 3625762 c.852A>G synonymous_variant 0.26 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625765 c.849C>G synonymous_variant 0.26 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625797 p.Val273Met missense_variant 0.27 bedaquiline Uncertain significance
rifampicin Uncertain significance
mtrB 3625806 c.808A>C synonymous_variant 0.29 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625837 c.777C>G synonymous_variant 0.2 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625840 c.-930A>G upstream_gene_variant 0.18 bedaquiline
rifampicin
mtrB 3626562 p.Pro18Ser missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
mtrB 3626840 c.-227C>G upstream_gene_variant 0.24 bedaquiline
rifampicin
mtrA 3626846 c.504G>A synonymous_variant 0.27 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626858 c.-245A>G upstream_gene_variant 0.27 bedaquiline
rifampicin
mtrB 3626861 c.-248C>G upstream_gene_variant 0.26 bedaquiline
rifampicin
mtrB 3626866 c.-253T>C upstream_gene_variant 0.25 bedaquiline
rifampicin
mtrB 3626885 c.-272A>C upstream_gene_variant 0.24 bedaquiline
rifampicin
mtrB 3626903 c.-290T>C upstream_gene_variant 0.23 bedaquiline
rifampicin
mtrA 3626912 c.438T>C synonymous_variant 0.24 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626930 c.-317A>T upstream_gene_variant 0.3 bedaquiline
rifampicin
mtrA 3626939 c.411A>G synonymous_variant 0.3 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626942 c.-329A>G upstream_gene_variant 0.31 bedaquiline
rifampicin
mtrB 3627065 c.-452G>C upstream_gene_variant 0.19 bedaquiline
rifampicin
mtrA 3627068 c.282T>C synonymous_variant 0.17 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627074 c.-461G>C upstream_gene_variant 0.16 bedaquiline
rifampicin
mtrA 3627098 c.252A>C synonymous_variant 0.18 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3627242 c.108C>T synonymous_variant 0.17 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627254 c.-641C>T upstream_gene_variant 0.17 bedaquiline
rifampicin
mtrB 3627263 c.-650C>T upstream_gene_variant 0.17 bedaquiline
rifampicin
mtrB 3627272 c.-659G>T upstream_gene_variant 0.17 bedaquiline
rifampicin
fbiB 3642668 c.1134A>C synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiB 3642677 c.1143A>G synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiB 3642680 c.1146A>G synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiB 3642684 c.1150T>C synonymous_variant 0.19 clofazimine
pretomanid
delamanid
alr 3840467 c.952_954delGTGinsAC frameshift_variant&missense_variant 0.18 cycloserine
alr 3840476 c.945A>C synonymous_variant 0.18 cycloserine
alr 3840482 c.939T>C synonymous_variant 0.17 cycloserine
rpoA 3877587 c.921A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoA 3877613 p.Ile299Val missense_variant 0.18 rifampicin
rpoA 3877638 c.870T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoA 3877818 c.690A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoA 3877839 c.669G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoA 3877857 c.651G>A synonymous_variant 0.2 rifampicin
rpoA 3877866 c.642G>C synonymous_variant 0.18 rifampicin
rpoA 3877872 c.636C>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3877875 c.633T>G synonymous_variant 0.24 rifampicin
rpoA 3877899 p.Ser203Thr missense_variant 0.22 rifampicin
rpoA 3877905 c.603A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoA 3877908 p.Asn200Ser missense_variant 0.2 rifampicin
rpoA 3877962 c.546G>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoA 3878082 c.426T>C synonymous_variant 0.17 rifampicin
rpoA 3878094 c.414C>G synonymous_variant 0.17 rifampicin
rpoA 3878100 c.408C>G synonymous_variant 0.17 rifampicin
rpoA 3878103 c.405A>G synonymous_variant 0.17 rifampicin
rpoA 3878106 c.402G>C synonymous_variant 0.17 rifampicin
rpoA 3878118 c.390T>C synonymous_variant 0.17 rifampicin
rpoA 3878143 p.Gly122Asp missense_variant 0.17 rifampicin Uncertain significance
rpoA 3878376 c.132G>C synonymous_variant 0.23 rifampicin
rpoA 3878385 c.123C>G synonymous_variant 0.24 rifampicin
rpoA 3878391 c.117T>C synonymous_variant 0.25 rifampicin
rpoA 3878396 c.112C>T synonymous_variant 0.26 rifampicin
rpoA 3878436 c.72A>G synonymous_variant 0.32 rifampicin
rpoA 3878442 c.66G>C synonymous_variant 0.33 rifampicin
ddn 3986655 c.-189A>T upstream_gene_variant 0.17 delamanid
pretomanid
ddn 3986660 c.-184C>T upstream_gene_variant 0.17 delamanid
pretomanid
ddn 3986665 c.-179G>C upstream_gene_variant 0.17 delamanid
pretomanid
ddn 3986667 c.-177_-176delCTinsAC upstream_gene_variant 0.18 delamanid
pretomanid
ddn 3986681 c.-163C>G upstream_gene_variant 0.2 delamanid
pretomanid
ddn 3986690 c.-154C>G upstream_gene_variant 0.2 delamanid
pretomanid
ddn 3986696 c.-148G>T upstream_gene_variant 0.2 delamanid
pretomanid
ddn 3986699 c.-145C>G upstream_gene_variant 0.19 delamanid
pretomanid
clpC1 4038278 c.2427T>C synonymous_variant 0.19 pyrazinamide
clpC1 4038293 c.2412G>C synonymous_variant 0.24 pyrazinamide
clpC1 4038302 c.2403C>A synonymous_variant 0.24 pyrazinamide
clpC1 4038308 c.2395_2397delGTGinsAC frameshift_variant&missense_variant 0.21 pyrazinamide
clpC1 4038317 c.2388G>C synonymous_variant 0.22 pyrazinamide
clpC1 4038530 p.Glu725Asp missense_variant 0.19 pyrazinamide
clpC1 4038536 c.2169C>T synonymous_variant 0.22 pyrazinamide Not assoc w R - Interim
clpC1 4038596 c.2109A>G synonymous_variant 0.29 pyrazinamide
clpC1 4038790 c.1915C>T synonymous_variant 0.21 pyrazinamide Not assoc w R - Interim
clpC1 4038812 c.1893T>C synonymous_variant 0.23 pyrazinamide
clpC1 4038815 c.1890G>T synonymous_variant 0.23 pyrazinamide
clpC1 4038860 c.1845G>A synonymous_variant 0.29 pyrazinamide
clpC1 4038878 c.1827A>G synonymous_variant 0.31 pyrazinamide Not assoc w R - Interim
clpC1 4038908 c.1797C>G synonymous_variant 0.29 pyrazinamide
clpC1 4038914 c.1791G>C synonymous_variant 0.29 pyrazinamide
clpC1 4038923 c.1782A>G synonymous_variant 0.33 pyrazinamide
clpC1 4038932 c.1773G>C synonymous_variant 0.27 pyrazinamide
clpC1 4038953 c.1752A>G synonymous_variant 0.23 pyrazinamide
clpC1 4038956 c.1749T>C synonymous_variant 0.22 pyrazinamide
clpC1 4038965 c.1740T>C synonymous_variant 0.2 pyrazinamide
clpC1 4038971 c.1734T>C synonymous_variant 0.18 pyrazinamide
clpC1 4038974 c.1731T>C synonymous_variant 0.18 pyrazinamide Not assoc w R - Interim
clpC1 4038997 c.1708T>C synonymous_variant 0.22 pyrazinamide Not assoc w R - Interim
clpC1 4039022 c.1683A>G synonymous_variant 0.22 pyrazinamide
clpC1 4039073 c.1632C>G synonymous_variant 0.22 pyrazinamide
clpC1 4039085 c.1620A>G synonymous_variant 0.19 pyrazinamide
clpC1 4039090 c.1615C>T synonymous_variant 0.19 pyrazinamide
clpC1 4039097 c.1608G>C synonymous_variant 0.2 pyrazinamide
clpC1 4039103 c.1602T>C synonymous_variant 0.21 pyrazinamide
clpC1 4039112 c.1593C>G synonymous_variant 0.21 pyrazinamide
clpC1 4039121 c.1584T>C synonymous_variant 0.22 pyrazinamide
clpC1 4039124 c.1581C>G synonymous_variant 0.22 pyrazinamide
clpC1 4039142 c.1563A>G synonymous_variant 0.17 pyrazinamide
clpC1 4039145 c.1560G>C synonymous_variant 0.19 pyrazinamide
clpC1 4039169 p.Glu512Asp missense_variant 0.2 pyrazinamide
clpC1 4039172 c.1533A>G synonymous_variant 0.2 pyrazinamide
clpC1 4039178 c.1527G>C synonymous_variant 0.2 pyrazinamide
clpC1 4039183 c.1522T>C synonymous_variant 0.21 pyrazinamide
clpC1 4039187 c.1518G>C synonymous_variant 0.2 pyrazinamide
clpC1 4039190 c.1515C>G synonymous_variant 0.2 pyrazinamide
clpC1 4039268 c.1437C>G synonymous_variant 0.18 pyrazinamide
clpC1 4039274 c.1431G>C synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
clpC1 4039286 c.1419T>C synonymous_variant 0.22 pyrazinamide
clpC1 4039289 c.1416T>C synonymous_variant 0.22 pyrazinamide
clpC1 4039295 c.1410A>C synonymous_variant 0.22 pyrazinamide
clpC1 4039298 c.1407T>C synonymous_variant 0.22 pyrazinamide
clpC1 4039319 c.1386T>C synonymous_variant 0.18 pyrazinamide Not assoc w R - Interim
clpC1 4039328 c.1377A>G synonymous_variant 0.17 pyrazinamide
clpC1 4039391 c.1314T>G synonymous_variant 0.19 pyrazinamide
clpC1 4039409 c.1296T>C synonymous_variant 0.18 pyrazinamide
clpC1 4039610 c.1095G>C synonymous_variant 0.17 pyrazinamide
clpC1 4039616 c.1089G>C synonymous_variant 0.17 pyrazinamide
clpC1 4039622 c.1083C>G synonymous_variant 0.17 pyrazinamide
clpC1 4039817 c.888A>T synonymous_variant 0.22 pyrazinamide
clpC1 4039820 c.885T>G synonymous_variant 0.23 pyrazinamide
clpC1 4039831 c.874T>C synonymous_variant 0.22 pyrazinamide
clpC1 4039832 c.873C>G synonymous_variant 0.22 pyrazinamide
clpC1 4039850 c.855T>C synonymous_variant 0.24 pyrazinamide
clpC1 4039865 c.840T>C synonymous_variant 0.22 pyrazinamide
clpC1 4039886 c.819C>G synonymous_variant 0.24 pyrazinamide
clpC1 4039898 c.807C>G synonymous_variant 0.26 pyrazinamide
clpC1 4039904 c.801A>G synonymous_variant 0.27 pyrazinamide
clpC1 4039928 c.775_777delAGCinsTCG synonymous_variant 0.25 pyrazinamide
clpC1 4039931 c.774T>C synonymous_variant 0.25 pyrazinamide
clpC1 4039946 c.759A>T synonymous_variant 0.25 pyrazinamide
clpC1 4039952 c.753T>C synonymous_variant 0.23 pyrazinamide
clpC1 4039958 c.747G>C synonymous_variant 0.23 pyrazinamide
clpC1 4039979 c.726C>G synonymous_variant 0.2 pyrazinamide
clpC1 4039996 p.Glu237Gln missense_variant 0.17 pyrazinamide
clpC1 4040021 c.684A>C synonymous_variant 0.18 pyrazinamide Not assoc w R - Interim
clpC1 4040024 c.681A>G synonymous_variant 0.18 pyrazinamide
clpC1 4040090 c.613_615delTCTinsAGC synonymous_variant 0.17 pyrazinamide
clpC1 4040093 c.612C>G synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
clpC1 4040105 c.600C>G synonymous_variant 0.21 pyrazinamide
clpC1 4040123 c.582G>A synonymous_variant 0.26 pyrazinamide
clpC1 4040147 c.558A>G synonymous_variant 0.24 pyrazinamide Not assoc w R - Interim
clpC1 4040153 c.552A>G synonymous_variant 0.25 pyrazinamide
clpC1 4040162 c.543G>C synonymous_variant 0.22 pyrazinamide Not assoc w R - Interim
clpC1 4040165 c.540G>C synonymous_variant 0.21 pyrazinamide
clpC1 4040168 c.537G>C synonymous_variant 0.21 pyrazinamide
clpC1 4040171 c.534C>G synonymous_variant 0.21 pyrazinamide
clpC1 4040201 c.504C>G synonymous_variant 0.16 pyrazinamide
clpC1 4040237 c.468C>T synonymous_variant 0.14 pyrazinamide
glpK 4138568 c.1188A>G synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138571 c.1185C>G synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138583 c.1173G>C synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138586 c.1170C>T synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138631 c.1125C>G synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138634 c.1122G>T synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138643 c.1113A>C synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
embC 4240561 c.699C>G synonymous_variant 0.16 ethambutol
embC 4240591 c.729C>G synonymous_variant 0.16 ethambutol
embC 4240594 c.732C>G synonymous_variant 0.18 ethambutol
embC 4240600 c.738G>C synonymous_variant 0.17 ethambutol
embC 4240632 p.Met257Thr missense_variant 0.16 ethambutol
embC 4240642 c.780G>C synonymous_variant 0.17 ethambutol
embC 4240645 c.783G>C synonymous_variant 0.17 ethambutol
embC 4240657 c.795G>C synonymous_variant 0.2 ethambutol
embC 4240671 p.Thr270Ile missense_variant 0.26 ethambutol Not assoc w R
embC 4240678 c.816T>G synonymous_variant 0.25 ethambutol
embC 4240685 c.823_825delACCinsGG frameshift_variant&missense_variant 0.24 ethambutol
embC 4240693 c.831T>C synonymous_variant 0.24 ethambutol
embC 4240706 p.Val282Thr missense_variant 0.2 ethambutol
embC 4240726 c.864G>C synonymous_variant 0.18 ethambutol Not assoc w R - Interim
embC 4240780 c.918T>C synonymous_variant 0.17 ethambutol
embC 4240783 c.921G>C synonymous_variant 0.18 ethambutol
embC 4240789 c.927T>C synonymous_variant 0.2 ethambutol
embC 4240819 c.957A>G synonymous_variant 0.25 ethambutol
embC 4240831 c.969T>G synonymous_variant 0.24 ethambutol
embC 4240867 c.1005T>G synonymous_variant 0.24 ethambutol
embC 4240870 c.1008T>C synonymous_variant 0.24 ethambutol
embC 4240879 c.1017G>C synonymous_variant 0.23 ethambutol
embC 4240880 p.Ala340Thr missense_variant 0.24 ethambutol Uncertain significance
embC 4240885 c.1023T>C synonymous_variant 0.23 ethambutol
embC 4240897 c.1035C>G synonymous_variant 0.21 ethambutol Not assoc w R
embC 4240900 c.1038A>G synonymous_variant 0.22 ethambutol
embC 4240919 c.1057_1059delCTCinsTG frameshift_variant&missense_variant 0.21 ethambutol
embC 4240936 c.1074A>G synonymous_variant 0.23 ethambutol
embC 4240945 c.1083T>C synonymous_variant 0.18 ethambutol
embC 4240951 c.1089C>G synonymous_variant 0.2 ethambutol
embC 4240954 p.Ile364Met missense_variant 0.17 ethambutol
embC 4240957 c.1095C>G synonymous_variant 0.18 ethambutol
embC 4240980 p.Thr373Lys missense_variant 0.16 ethambutol
embC 4240983 p.Ser374Asn missense_variant 0.17 ethambutol
embC 4240990 c.1128A>G synonymous_variant 0.16 ethambutol
embC 4241137 c.1275G>C synonymous_variant 0.19 ethambutol
embC 4241140 c.1278A>G synonymous_variant 0.19 ethambutol Not assoc w R - Interim
embC 4241141 p.Ile427Val missense_variant 0.19 ethambutol Uncertain significance
embC 4241158 c.1296T>C synonymous_variant 0.18 ethambutol
embC 4241161 c.1299C>G synonymous_variant 0.19 ethambutol Not assoc w R - Interim
embC 4241162 c.1300T>C synonymous_variant 0.19 ethambutol
embC 4242643 c.2781C>T synonymous_variant 0.97 ethambutol Not assoc w R
embA 4243460 c.228C>T synonymous_variant 1.0 ethambutol Not assoc w R
embA 4245137 c.1905T>C synonymous_variant 0.16 ethambutol
embA 4245185 c.1953G>T synonymous_variant 0.14 ethambutol
embA 4245194 c.1962G>C synonymous_variant 0.17 ethambutol
embA 4245198 p.Leu656Ile missense_variant 0.17 ethambutol
embB 4245725 c.-789A>C upstream_gene_variant 0.23 ethambutol
embA 4245726 c.2494_2496delTTGinsCC frameshift_variant&missense_variant 0.23 ethambutol Uncertain significance
embB 4245737 c.-777A>C upstream_gene_variant 0.26 ethambutol
embB 4245740 c.-774T>C upstream_gene_variant 0.26 ethambutol
embB 4245764 c.-750G>C upstream_gene_variant 0.26 ethambutol
embA 4245771 p.Asn847Ser missense_variant 0.25 ethambutol Uncertain significance
embA 4245807 c.2575_2577delTTAinsCG frameshift_variant&missense_variant 0.2 ethambutol Uncertain significance
embA 4245820 p.Ser863Thr missense_variant 0.17 ethambutol
embB 4245830 c.-684G>C upstream_gene_variant 0.18 ethambutol
embB 4245845 c.-669T>G upstream_gene_variant 0.15 ethambutol
embB 4245848 c.-666C>G upstream_gene_variant 0.17 ethambutol
embB 4248142 c.1629T>C synonymous_variant 0.16 ethambutol
embB 4249469 p.Leu986Met missense_variant 0.15 ethambutol
embB 4249486 c.2973T>G synonymous_variant 0.16 ethambutol
aftB 4267580 c.1257G>C synonymous_variant 0.25 ethambutol
aftB 4267607 c.1230G>A synonymous_variant 0.26 ethambutol
aftB 4267647 p.Asp397Gly missense_variant 0.88 ethambutol Not assoc w R
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 capreomycin
amikacin
kanamycin
gid 4407588 c.615A>G synonymous_variant 1.0 streptomycin Not assoc w R
gid 4407927 p.Glu92Asp missense_variant 1.0 streptomycin Not assoc w R