TB-Profiler result

Run: SRR1173767
Summary

Run ID: SRR1173767

Sample name:

Date: 2024-04-15T07:41:35.692087

Number of reads: 1366691

Percentage reads mapped: 75.06

Median coverage: 30.0

Strain: lineage4.4.1.1

Spoligotype:

Drug-resistance: MDR-TB

Download CSV Download TXT Download JSON
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage4.4.1 Euro-American (S-type) None 0.92
lineage4 Euro-American None 0.98
lineage4.4.1.1 Euro-American None 0.95
lineage4.4 Euro-American None 0.93
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin rpoB c.1327_1329delTTGinsCC Assoc w R - Interim Expert rule: Non-silent variants in RRDR of rpoB
isoniazid katG p.Ile335Thr Mutation from literature
ethambutol
pyrazinamide
streptomycin rrs n.462C>T Uncertain significance Mutation from literature
gid c.115delC Assoc w R
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid fbiC c.1948_1950delCGCinsAG Assoc w R - Interim Confers DLM-PMD cross-resistance
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
rpoB 761133 c.1327_1329delTTGinsCC frameshift_variant&missense_variant 0.21 rifampicin Assoc w R - Interim Expert rule: Non-silent variants in RRDR of rpoB
fbiC 1304878 c.1948_1950delCGCinsAG frameshift_variant&missense_variant 0.28 delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
rrs 1472307 n.462C>T non_coding_transcript_exon_variant 0.4 streptomycin Uncertain significance Mutation from literature
katG 2155108 p.Ile335Thr missense_variant 0.16 isoniazid Mutation from literature
gid 4408087 c.115delC frameshift_variant 1.0 streptomycin Assoc w R
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
dnaA 571 c.571T>C synonymous_variant 0.21 isoniazid
dnaA 576 c.576G>C synonymous_variant 0.2 isoniazid
dnaA 582 c.582A>C synonymous_variant 0.19 isoniazid Not assoc w R - Interim
dnaA 591 c.591C>G synonymous_variant 0.18 isoniazid
dnaA 609 c.609C>G synonymous_variant 0.18 isoniazid
dnaA 610 c.610C>T synonymous_variant 0.18 isoniazid
dnaA 777 c.777A>G synonymous_variant 0.17 isoniazid
dnaA 786 c.786C>T synonymous_variant 0.2 isoniazid
dnaA 795 c.795A>C synonymous_variant 0.18 isoniazid Not assoc w R - Interim
dnaA 805 c.805T>C synonymous_variant 0.17 isoniazid
dnaA 1104 c.1104T>C synonymous_variant 0.17 isoniazid
dnaA 1110 c.1110T>C synonymous_variant 0.15 isoniazid
dnaA 1125 c.1125G>C synonymous_variant 0.19 isoniazid
dnaA 1191 c.1191T>C synonymous_variant 0.16 isoniazid
dnaA 1278 c.1278T>C synonymous_variant 0.16 isoniazid
gyrB 6280 c.1041T>C synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrB 6286 c.1047T>C synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrB 6292 c.1053G>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrB 6295 c.1056A>G synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrB 6298 c.1059C>T synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6299 c.1060C>T synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrB 6307 c.1068T>G synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6319 c.1080G>C synonymous_variant 0.3 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 6325 c.-977C>G upstream_gene_variant 0.35 levofloxacin
moxifloxacin
gyrA 6361 c.-941G>A upstream_gene_variant 0.32 levofloxacin
moxifloxacin
gyrA 6362 c.-940T>C upstream_gene_variant 0.3 levofloxacin
moxifloxacin
gyrA 6379 c.-923C>G upstream_gene_variant 0.32 levofloxacin
moxifloxacin
gyrA 6382 c.-920A>G upstream_gene_variant 0.32 levofloxacin
moxifloxacin
gyrA 6388 c.-914T>C upstream_gene_variant 0.3 levofloxacin
moxifloxacin
gyrA 6400 c.-902C>G upstream_gene_variant 0.24 levofloxacin
moxifloxacin
gyrA 6403 c.-899T>C upstream_gene_variant 0.23 levofloxacin
moxifloxacin
gyrA 6670 c.-632G>C upstream_gene_variant 0.18 levofloxacin
moxifloxacin
gyrA 6673 c.-629A>C upstream_gene_variant 0.18 levofloxacin
moxifloxacin
gyrB 6745 c.1506T>G synonymous_variant 0.14 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6778 c.-524C>T upstream_gene_variant 0.15 levofloxacin
moxifloxacin
gyrB 6793 c.1554T>C synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6797 p.Gly520Thr missense_variant 0.2 levofloxacin
moxifloxacin
gyrB 6824 c.1585C>T synonymous_variant 0.29 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6841 c.1602T>C synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6844 c.-458T>G upstream_gene_variant 0.23 levofloxacin
moxifloxacin
gyrA 6853 c.-449A>G upstream_gene_variant 0.19 levofloxacin
moxifloxacin
gyrB 6856 c.1617T>C synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6859 c.1620T>C synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6862 c.1623C>G synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6878 c.1639T>C synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6881 c.1642T>C synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7427 c.126G>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 7442 c.141G>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7763 c.462T>C synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8090 c.789C>G synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 8099 c.798T>C synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 8111 c.810G>C synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 8156 c.855T>C synonymous_variant 0.31 levofloxacin
moxifloxacin
gyrA 8168 c.867A>G synonymous_variant 0.34 levofloxacin
moxifloxacin
gyrA 8174 c.873C>G synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 8177 c.876A>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8253 p.Ile318Leu missense_variant 0.18 levofloxacin
moxifloxacin
gyrA 8264 c.963T>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8267 c.966G>C synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8270 c.969G>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8283 c.982_984delATCinsCG frameshift_variant&missense_variant 0.21 levofloxacin
moxifloxacin
gyrA 8288 c.987T>C synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8294 c.993T>C synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8324 c.1023T>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8399 c.1098T>C synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8420 c.1119T>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8423 c.1122G>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8453 c.1152A>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8462 c.1161A>G synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8471 c.1170T>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8537 c.1236G>A synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8672 c.1371A>G synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9304 p.Gly668Glu missense_variant 1.0 levofloxacin
moxifloxacin
gyrA 9335 c.2034G>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 9345 c.2044A>C synonymous_variant 0.23 levofloxacin
moxifloxacin
fgd1 490887 c.105G>C synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fgd1 490902 c.120T>C synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fgd1 490905 c.123T>C synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fgd1 490911 c.129T>G synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fgd1 490917 c.135C>G synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fgd1 490921 p.Gln47Glu missense_variant 0.16 clofazimine
pretomanid
delamanid
fgd1 491526 c.744T>C synonymous_variant 0.35 clofazimine
pretomanid
delamanid
fgd1 491542 c.760T>C synonymous_variant 0.39 clofazimine
pretomanid
delamanid
fgd1 491547 c.765A>C synonymous_variant 0.41 clofazimine
pretomanid
delamanid
fgd1 491550 c.768T>C synonymous_variant 0.41 clofazimine
pretomanid
delamanid
ccsA 620241 c.351C>T synonymous_variant 0.71 capreomycin Not assoc w R - Interim
amikacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
ccsA 620412 c.522T>C synonymous_variant 0.35 capreomycin
amikacin
kanamycin
ccsA 620415 c.525T>C synonymous_variant 0.35 capreomycin Not assoc w R - Interim
amikacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
ccsA 620433 c.543C>G synonymous_variant 0.32 capreomycin Not assoc w R - Interim
amikacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
ccsA 620436 c.546T>C synonymous_variant 0.32 capreomycin
amikacin
kanamycin
ccsA 620439 c.549T>C synonymous_variant 0.33 capreomycin
amikacin
kanamycin
ccsA 620445 c.555A>G synonymous_variant 0.29 capreomycin
amikacin
kanamycin
Rv0565c 657219 p.Ala84Val missense_variant 0.19 ethionamide
Rv0565c 657222 c.249C>G synonymous_variant 0.21 ethionamide
Rv0565c 657231 c.238_240delATCinsGG frameshift_variant&missense_variant 0.19 ethionamide Uncertain significance
Rv0565c 657237 c.234A>G synonymous_variant 0.18 ethionamide
Rv0565c 657242 p.Glu77Lys missense_variant 0.18 ethionamide
Rv0565c 657259 p.Tyr71Phe missense_variant 0.19 ethionamide
Rv0565c 657261 c.210C>G synonymous_variant 0.19 ethionamide
Rv0565c 657264 c.207T>C synonymous_variant 0.19 ethionamide
Rv0565c 657267 c.204G>C synonymous_variant 0.19 ethionamide
Rv0565c 657632 c.-162G>A upstream_gene_variant 0.24 ethionamide
Rv0565c 657639 c.-169C>G upstream_gene_variant 0.27 ethionamide
Rv0565c 657641 c.-171C>G upstream_gene_variant 0.28 ethionamide
Rv0565c 657649 c.-179G>A upstream_gene_variant 0.29 ethionamide
hadA 732253 c.324T>C synonymous_variant 0.2 isoniazid
hadA 732259 c.330T>C synonymous_variant 0.18 isoniazid
hadA 732268 c.339T>G synonymous_variant 0.23 isoniazid
hadA 732270 p.Glu114Val missense_variant 0.22 isoniazid
hadA 732272 p.Ala115Ser missense_variant 0.21 isoniazid
hadA 732295 c.366G>C synonymous_variant 0.24 isoniazid
hadA 732304 c.375C>T synonymous_variant 0.27 isoniazid
hadA 732305 p.Ile126Val missense_variant 0.28 isoniazid
hadA 732308 p.Val127Ile missense_variant 0.28 isoniazid
hadA 732321 p.Glu131Ala missense_variant 0.29 isoniazid
hadA 732329 p.Leu134Val missense_variant 0.35 isoniazid Uncertain significance
hadA 732337 c.408G>A synonymous_variant 0.32 isoniazid
hadA 732346 c.417T>C synonymous_variant 0.28 isoniazid
hadA 732378 c.450_452dupAGA disruptive_inframe_insertion 0.28 isoniazid
hadA 732389 p.Ser154Thr missense_variant 0.29 isoniazid
hadA 732396 p.Gly156Ala missense_variant 0.29 isoniazid
hadA 732398 p.Ala157Thr missense_variant 0.29 isoniazid
nusG 734847 c.594T>C synonymous_variant 0.23 rifampicin
nusG 734853 c.600A>C synonymous_variant 0.21 rifampicin
nusG 734854 c.601T>C synonymous_variant 0.21 rifampicin
nusG 734865 c.612G>C synonymous_variant 0.26 rifampicin
rpoB 760181 c.375T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760184 c.378A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760196 c.390C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 760223 c.417T>C synonymous_variant 0.15 rifampicin
rpoB 760235 c.429T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760283 c.477G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760328 c.522G>C synonymous_variant 0.26 rifampicin
rpoB 760331 c.525G>C synonymous_variant 0.26 rifampicin
rpoB 760337 c.531C>G synonymous_variant 0.28 rifampicin
rpoB 760340 c.534G>C synonymous_variant 0.26 rifampicin
rpoB 760361 c.555T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 760376 p.Asp190Glu missense_variant 0.3 rifampicin Uncertain significance
rpoB 760406 c.600G>C synonymous_variant 0.34 rifampicin
rpoB 760655 c.849A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760661 c.855A>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760730 c.924T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760845 p.Thr347Pro missense_variant 0.2 rifampicin
rpoB 760859 c.1053T>C synonymous_variant 0.17 rifampicin
rpoB 760862 c.1056G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760869 p.Val355Ile missense_variant 0.19 rifampicin Uncertain significance
rpoB 760886 c.1080A>G synonymous_variant 0.17 rifampicin
rpoB 761021 c.1215G>C synonymous_variant 0.22 rifampicin
rpoB 761027 c.1221A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 761036 c.1230G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 761037 c.1231T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 761051 c.1245G>T synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 761054 c.1248G>A synonymous_variant 0.27 rifampicin
rpoB 761057 c.1251G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 761060 c.1254C>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 761063 c.1257C>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 761097 c.1291_1292delAGinsTC synonymous_variant 0.33 rifampicin
rpoB 761102 c.1296A>G synonymous_variant 0.34 rifampicin
rpoB 761150 c.1344A>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 761165 c.1359G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 761168 c.1362C>G synonymous_variant 0.29 rifampicin
rpoB 761171 c.1365C>T synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 761189 c.1383T>G synonymous_variant 0.29 rifampicin
rpoB 761297 c.1491C>T synonymous_variant 0.36 rifampicin
rpoB 761327 c.1521A>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 761531 c.1725C>G synonymous_variant 0.24 rifampicin
rpoB 761537 c.1731C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 761570 c.1764T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 761573 c.1767C>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 761579 c.1773G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 761606 c.1800C>G synonymous_variant 0.25 rifampicin
rpoB 761636 c.1830G>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 761645 c.1839C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 761648 c.1842T>C synonymous_variant 0.25 rifampicin
rpoB 761657 c.1851C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 761948 c.2142G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 761954 c.2148C>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 761969 c.2163G>A synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 761999 c.2193G>C synonymous_variant 0.28 rifampicin
rpoB 762008 c.2202C>G synonymous_variant 0.3 rifampicin
rpoB 762014 c.2208C>T synonymous_variant 0.31 rifampicin
rpoB 762017 c.2211A>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 762053 c.2247T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 762131 c.2325C>G synonymous_variant 0.33 rifampicin
rpoB 762140 c.2334G>C synonymous_variant 0.32 rifampicin
rpoB 762143 c.2337T>C synonymous_variant 0.35 rifampicin
rpoB 762149 c.2343G>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 762167 c.2361T>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 762176 c.2370T>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 762185 c.2379G>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 762218 c.2412T>G synonymous_variant 0.42 rifampicin
rpoC 762410 c.-960T>C upstream_gene_variant 0.29 rifampicin
rpoB 762416 c.2610A>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 762443 c.-927G>T upstream_gene_variant 0.24 rifampicin
rpoB 762470 c.2664G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 762521 c.-849C>G upstream_gene_variant 0.2 rifampicin
rpoC 762533 c.-837T>C upstream_gene_variant 0.21 rifampicin
rpoC 762536 c.-834T>C upstream_gene_variant 0.2 rifampicin
rpoC 762537 c.-833T>C upstream_gene_variant 0.2 rifampicin
rpoC 762551 c.-819C>T upstream_gene_variant 0.21 rifampicin
rpoB 762929 c.3123G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 762989 c.-381G>C upstream_gene_variant 0.2 rifampicin
rpoB 763040 c.3234C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 763070 c.3264T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 763076 c.-294C>G upstream_gene_variant 0.26 rifampicin
rpoB 763085 c.3279C>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 763115 c.3309T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 763136 c.3330C>T synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 763148 c.-222G>C upstream_gene_variant 0.29 rifampicin
rpoC 763158 c.-212C>T upstream_gene_variant 0.24 rifampicin
rpoB 763166 c.3360A>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 763169 c.-201A>G upstream_gene_variant 0.3 rifampicin
rpoC 763202 c.-168A>C upstream_gene_variant 0.25 rifampicin
rpoC 763205 c.-165G>C upstream_gene_variant 0.25 rifampicin
rpoC 763206 c.-164_-162delAGTinsTCC upstream_gene_variant 0.26 rifampicin
rpoB 763214 c.3408T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 763226 c.-144A>G upstream_gene_variant 0.28 rifampicin
rpoB 763238 c.3432T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 763402 c.33C>G synonymous_variant 0.23 rifampicin
rpoC 763411 c.42T>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 763414 c.45T>C synonymous_variant 0.23 rifampicin
rpoC 763441 c.72C>G synonymous_variant 0.36 rifampicin
rpoC 763444 c.75T>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 763456 c.87A>G synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 763468 c.99G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 763486 c.117T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 763528 c.159G>A synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 763594 c.225C>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 763735 c.366G>C synonymous_variant 0.24 rifampicin
rpoC 763744 c.375G>C synonymous_variant 0.25 rifampicin
rpoC 763765 c.396T>C synonymous_variant 0.28 rifampicin
rpoC 763768 c.399C>G synonymous_variant 0.29 rifampicin
rpoC 763780 c.411C>G synonymous_variant 0.34 rifampicin
rpoC 763783 c.414G>C synonymous_variant 0.31 rifampicin
rpoC 763801 c.432C>G synonymous_variant 0.27 rifampicin
rpoC 763807 c.438T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 763819 c.450G>C synonymous_variant 0.29 rifampicin
rpoC 763945 c.576T>C synonymous_variant 0.35 rifampicin
rpoC 763960 c.591T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 763967 p.Gly200Ser missense_variant 0.29 rifampicin
rpoC 763978 c.609C>G synonymous_variant 0.29 rifampicin
rpoC 763996 c.627T>C synonymous_variant 0.31 rifampicin
rpoC 764005 c.636G>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 764011 c.642T>C synonymous_variant 0.33 rifampicin
rpoC 764024 c.655T>C synonymous_variant 0.33 rifampicin
rpoC 764040 p.Ser224Asn missense_variant 0.31 rifampicin
rpoC 764044 c.675T>C synonymous_variant 0.29 rifampicin
rpoC 764059 c.690G>C synonymous_variant 0.33 rifampicin
rpoC 764083 c.714A>G synonymous_variant 0.37 rifampicin
rpoC 764098 c.729A>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 764101 c.732C>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 764110 c.741C>T synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 764131 c.762T>C synonymous_variant 0.37 rifampicin
rpoC 764161 c.792G>C synonymous_variant 0.31 rifampicin
rpoC 764188 c.819A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 764195 p.Ser276Gln missense_variant 0.24 rifampicin
rpoC 764203 c.834G>T synonymous_variant 0.23 rifampicin
rpoC 764206 c.837T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764257 c.888G>C synonymous_variant 0.23 rifampicin
rpoC 764365 c.996C>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764431 c.1062G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764434 c.1065A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764503 c.1134G>C synonymous_variant 0.3 rifampicin
rpoC 764626 c.1257C>T synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 764632 c.1263T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>T synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 764695 c.1326T>C synonymous_variant 0.39 rifampicin
rpoC 764752 c.1383G>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 764764 c.1395T>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 764791 c.1422C>G synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 764809 c.1440C>T synonymous_variant 0.39 rifampicin Not assoc w R
rpoC 764812 c.1443C>G synonymous_variant 0.39 rifampicin
rpoC 764815 c.1446A>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 764824 c.1455T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 764830 c.1461C>G synonymous_variant 0.33 rifampicin
rpoC 764858 c.1489T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764872 c.1503A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764878 c.1509C>G synonymous_variant 0.22 rifampicin
rpoC 764893 c.1524T>C synonymous_variant 0.26 rifampicin
rpoC 764911 c.1542A>G synonymous_variant 0.27 rifampicin
rpoC 764923 c.1554A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 764932 c.1563C>A synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 764968 c.1599T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764995 c.1626C>G synonymous_variant 0.18 rifampicin Not assoc w R
rpoC 765007 c.1638T>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 765352 c.1983G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 765383 p.Met672Leu missense_variant 0.25 rifampicin Uncertain significance
rpoC 765499 c.2130C>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 765508 c.2139C>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 765541 c.2172C>G synonymous_variant 0.36 rifampicin
rpoC 765553 c.2184C>T synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 765556 c.2187G>C synonymous_variant 0.31 rifampicin
rpoC 765559 c.2190G>C synonymous_variant 0.31 rifampicin
rpoC 765577 c.2208G>C synonymous_variant 0.26 rifampicin
rpoC 765578 c.2209C>T synonymous_variant 0.29 rifampicin
rpoC 765583 c.2214G>T synonymous_variant 0.31 rifampicin
rpoC 765613 p.His748Gln missense_variant 0.33 rifampicin
rpoC 765625 c.2256C>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 765628 c.2259G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 765631 p.Asp754Glu missense_variant 0.27 rifampicin
rpoC 765658 c.2289C>T synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 765700 c.2331T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 765772 c.2403C>G synonymous_variant 0.24 rifampicin
rpoC 765784 c.2415C>G synonymous_variant 0.25 rifampicin
rpoC 765796 c.2427C>T synonymous_variant 0.24 rifampicin
rpoC 765811 c.2442T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 765814 c.2445A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 765826 c.2457T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 765835 c.2466C>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 765892 c.2523T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 765928 c.2559C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 765967 c.2598C>T synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 765979 c.2610C>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 765982 c.2613C>T synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 765985 c.2616C>T synonymous_variant 0.28 rifampicin
rpoC 765994 c.2625A>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 766861 c.3492G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 766864 c.3495G>C synonymous_variant 0.33 rifampicin
rpoC 766894 c.3525T>C synonymous_variant 0.29 rifampicin
rpoC 766895 c.3526T>C synonymous_variant 0.29 rifampicin
rpoC 766900 c.3531T>C synonymous_variant 0.31 rifampicin
rpoC 767033 c.3664_3666delTCGinsAGC synonymous_variant 0.35 rifampicin
rpoC 767059 c.3690T>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 767062 c.3693C>A synonymous_variant 0.38 rifampicin
rpoC 767074 c.3705T>C synonymous_variant 0.38 rifampicin
rpoC 767098 c.3729T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 767119 c.3750A>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 767134 c.3765C>G synonymous_variant 0.33 rifampicin
rpoC 767158 c.3789T>G synonymous_variant 0.37 rifampicin
rpoC 767167 c.3798C>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 767221 c.3852C>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
mmpL5 775639 p.Ile948Val missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781682 c.123T>C synonymous_variant 0.32 streptomycin
rpsL 781715 c.156T>C synonymous_variant 0.33 streptomycin
rpsL 781793 c.234G>C synonymous_variant 0.37 streptomycin
rpsL 781841 c.282C>G synonymous_variant 0.4 streptomycin
rpsL 781859 c.300T>C synonymous_variant 0.42 streptomycin Not assoc w R - Interim
rpsL 781868 c.309T>C synonymous_variant 0.42 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.42 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.36 streptomycin
rpsL 781898 c.339A>T synonymous_variant 0.35 streptomycin
rpsL 781916 c.357T>C synonymous_variant 0.29 streptomycin
rpsL 781929 p.Gly124Ser missense_variant 0.27 streptomycin Uncertain significance
rplC 800516 c.-293G>T upstream_gene_variant 0.32 linezolid
rplC 800537 c.-272C>T upstream_gene_variant 0.38 linezolid
rplC 800540 c.-269T>C upstream_gene_variant 0.36 linezolid
rplC 800546 c.-263T>C upstream_gene_variant 0.36 linezolid
rplC 800582 c.-227C>G upstream_gene_variant 0.29 linezolid
rplC 800612 c.-197A>G upstream_gene_variant 0.26 linezolid
rplC 800618 c.-191T>C upstream_gene_variant 0.27 linezolid
rplC 800648 c.-161A>C upstream_gene_variant 0.32 linezolid
rplC 800654 c.-155T>C upstream_gene_variant 0.38 linezolid
rplC 800690 c.-119C>T upstream_gene_variant 0.35 linezolid
rplC 800693 c.-116A>G upstream_gene_variant 0.32 linezolid
rplC 800703 c.-106T>C upstream_gene_variant 0.36 linezolid
rplC 800715 c.-94A>C upstream_gene_variant 0.33 linezolid
rplC 800720 c.-89T>C upstream_gene_variant 0.33 linezolid
rplC 800723 c.-86C>G upstream_gene_variant 0.36 linezolid
rplC 800738 c.-71T>C upstream_gene_variant 0.33 linezolid
rplC 800747 c.-62C>G upstream_gene_variant 0.29 linezolid
rplC 800771 c.-38C>T upstream_gene_variant 0.24 linezolid
rplC 800814 c.6A>G synonymous_variant 0.15 linezolid
rplC 800817 c.9A>T synonymous_variant 0.15 linezolid
rplC 800844 c.36T>C synonymous_variant 0.16 linezolid
rplC 800916 c.108A>G synonymous_variant 0.26 linezolid
fbiC 1303512 c.582T>C synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1303534 p.Ser202Ala missense_variant 0.27 clofazimine
pretomanid
delamanid
fbiC 1304784 c.1854T>C synonymous_variant 0.43 clofazimine
pretomanid
delamanid
fbiC 1304817 c.1887T>C synonymous_variant 0.38 clofazimine
pretomanid
delamanid
fbiC 1304829 c.1899T>C synonymous_variant 0.44 clofazimine
pretomanid
delamanid
fbiC 1304832 c.1902C>G synonymous_variant 0.46 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1304853 c.1923C>G synonymous_variant 0.46 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1304856 c.1926C>G synonymous_variant 0.46 clofazimine
pretomanid
delamanid
fbiC 1304872 c.1942_1944delAGCinsTCG synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fbiC 1304877 c.1947T>C synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fbiC 1304893 p.Gly655Ser missense_variant 0.34 clofazimine
pretomanid
delamanid
fbiC 1305381 c.2451G>C synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1305393 c.2463T>C synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1305405 c.2475A>G synonymous_variant 0.21 clofazimine Not assoc w R - Interim
pretomanid
delamanid
fbiC 1305420 c.2490C>G synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1305423 c.2493T>C synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1305430 p.Val834Thr missense_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1305444 c.2514A>G synonymous_variant 0.25 clofazimine
pretomanid
delamanid
sigE 1364424 c.12C>T synonymous_variant 0.95 pyrazinamide Not assoc w R - Interim
atpE 1460831 c.-214T>C upstream_gene_variant 0.17 bedaquiline
atpE 1460855 c.-190T>C upstream_gene_variant 0.16 bedaquiline
atpE 1460858 c.-187C>G upstream_gene_variant 0.15 bedaquiline
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471923 n.78T>C non_coding_transcript_exon_variant 0.16 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471934 n.89A>G non_coding_transcript_exon_variant 0.17 streptomycin Uncertain significance
kanamycin
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471970 n.125G>A non_coding_transcript_exon_variant 0.15 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472028 n.183A>T non_coding_transcript_exon_variant 0.23 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472030 n.185G>A non_coding_transcript_exon_variant 0.24 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472031 n.186G>A non_coding_transcript_exon_variant 0.24 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472034 n.189T>C non_coding_transcript_exon_variant 0.24 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472044 n.199G>C non_coding_transcript_exon_variant 0.33 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472053 n.211_212delGC non_coding_transcript_exon_variant 0.31 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472061 n.216A>T non_coding_transcript_exon_variant 0.36 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472075 n.230A>G non_coding_transcript_exon_variant 0.33 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472969 n.1124A>G non_coding_transcript_exon_variant 0.16 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472970 n.1125C>G non_coding_transcript_exon_variant 0.16 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472977 n.1132G>C non_coding_transcript_exon_variant 0.16 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472978 n.1133T>C non_coding_transcript_exon_variant 0.15 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473104 n.1259C>T non_coding_transcript_exon_variant 0.2 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473105 n.1260G>A non_coding_transcript_exon_variant 0.2 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473123 n.1278delAinsTT non_coding_transcript_exon_variant 0.2 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.2 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.23 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473290 n.1445delCinsTTT non_coding_transcript_exon_variant 0.2 streptomycin
kanamycin
capreomycin
amikacin
rrl 1473756 n.99G>A non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1473758 n.101G>T non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid
rrl 1473806 n.149C>T non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473813 n.156C>T non_coding_transcript_exon_variant 0.28 capreomycin
linezolid
rrl 1473839 n.182G>T non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1473877 n.220G>A non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1473898 n.241C>T non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473899 n.242A>C non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473937 n.280C>T non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid
rrl 1473944 n.287G>A non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1473945 n.288T>C non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1474056 n.399T>C non_coding_transcript_exon_variant 0.34 capreomycin
linezolid
rrl 1474103 n.446A>T non_coding_transcript_exon_variant 0.42 capreomycin
linezolid
rrl 1474104 n.447G>A non_coding_transcript_exon_variant 0.42 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474111 n.454T>C non_coding_transcript_exon_variant 0.4 capreomycin
linezolid
rrl 1474112 n.455T>A non_coding_transcript_exon_variant 0.41 capreomycin
linezolid
rrl 1474140 n.483C>T non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474181 n.524C>T non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474639 n.982G>A non_coding_transcript_exon_variant 0.48 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.43 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.43 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474823 n.1166C>T non_coding_transcript_exon_variant 0.45 capreomycin
linezolid
rrl 1474831 n.1174A>G non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid
rrl 1474904 n.1247G>A non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1474970 n.1313G>A non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1474991 n.1334T>C non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1475006 n.1349A>T non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1475061 n.1404C>T non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid
rrl 1475088 n.1431A>T non_coding_transcript_exon_variant 0.41 capreomycin
linezolid
rrl 1475199 n.1542G>A non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1475206 n.1549C>T non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid
rrl 1475209 n.1552G>C non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid
rrl 1475213 n.1556C>T non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid
rrl 1475333 n.1676T>C non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1475355 n.1698C>T non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475369 n.1712G>C non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1475419 n.1762C>T non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid
rrl 1475483 n.1826C>T non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475505 n.1848G>A non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475599 n.1942A>G non_coding_transcript_exon_variant 0.18 capreomycin
linezolid Uncertain significance
rrl 1475608 n.1951T>C non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid
rrl 1475657 n.2000A>G non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1475659 n.2002G>T non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1475763 n.2106C>T non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid
rrl 1475881 n.2224T>C non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.29 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476025 n.2368G>T non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1476030 n.2373A>G non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid
rrl 1476032 n.2375C>A non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1476033 n.2376T>C non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid
rrl 1476034 n.2377C>A non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid
rrl 1476045 n.2388G>T non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid
rrl 1476047 n.2390G>T non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1476049 n.2392C>T non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476086 n.2429G>A non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476089 n.2432T>C non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1476095 n.2438C>G non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1476105 n.2448_2449delGAinsT non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1476115 n.2458T>C non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476117 n.2460G>C non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476583 n.2926G>A non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.23 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476597 n.2940G>A non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid
rrl 1476608 n.2951C>G non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
inhA 1674582 c.381T>C synonymous_variant 0.19 ethionamide
isoniazid
rpsA 1833619 c.78A>C synonymous_variant 0.27 pyrazinamide
rpsA 1833661 c.120A>G synonymous_variant 0.36 pyrazinamide
rpsA 1833667 c.126C>G synonymous_variant 0.36 pyrazinamide
rpsA 1833724 c.183C>G synonymous_variant 0.3 pyrazinamide
rpsA 1833727 c.186G>C synonymous_variant 0.27 pyrazinamide
rpsA 1833742 c.201A>G synonymous_variant 0.29 pyrazinamide
rpsA 1833745 c.204G>C synonymous_variant 0.26 pyrazinamide
rpsA 1833787 c.246C>G synonymous_variant 0.31 pyrazinamide
rpsA 1833790 c.249T>A synonymous_variant 0.3 pyrazinamide
rpsA 1833799 c.258C>G synonymous_variant 0.27 pyrazinamide
rpsA 1833811 c.270G>C synonymous_variant 0.32 pyrazinamide
rpsA 1833838 c.297G>C synonymous_variant 0.36 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.4 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.39 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.33 pyrazinamide
rpsA 1833862 c.321G>T synonymous_variant 0.36 pyrazinamide
rpsA 1833874 c.333T>C synonymous_variant 0.29 pyrazinamide
rpsA 1833940 c.399C>G synonymous_variant 0.23 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.27 pyrazinamide
rpsA 1834186 c.645C>G synonymous_variant 0.18 pyrazinamide
rpsA 1834189 c.648G>C synonymous_variant 0.17 pyrazinamide
rpsA 1834195 c.654G>C synonymous_variant 0.19 pyrazinamide
rpsA 1834201 c.660C>T synonymous_variant 0.23 pyrazinamide
rpsA 1834222 c.681T>C synonymous_variant 0.23 pyrazinamide
rpsA 1834225 c.684C>G synonymous_variant 0.2 pyrazinamide
rpsA 1834240 c.699T>C synonymous_variant 0.26 pyrazinamide
rpsA 1834249 c.708T>C synonymous_variant 0.27 pyrazinamide
rpsA 1834261 c.720A>C synonymous_variant 0.32 pyrazinamide
rpsA 1834264 c.723G>C synonymous_variant 0.34 pyrazinamide
rpsA 1834297 c.756C>G synonymous_variant 0.24 pyrazinamide
rpsA 1834303 c.762T>G synonymous_variant 0.23 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.21 pyrazinamide
rpsA 1834528 c.987T>C synonymous_variant 0.29 pyrazinamide
rpsA 1834546 c.1005T>C synonymous_variant 0.24 pyrazinamide
rpsA 1834555 c.1014T>C synonymous_variant 0.24 pyrazinamide
rpsA 1834558 c.1017C>G synonymous_variant 0.26 pyrazinamide
rpsA 1834622 c.1081_1083delTCGinsAGC synonymous_variant 0.23 pyrazinamide
rpsA 1834633 c.1092A>G synonymous_variant 0.24 pyrazinamide
rpsA 1834639 c.1098T>C synonymous_variant 0.24 pyrazinamide
rpsA 1834666 c.1125G>C synonymous_variant 0.28 pyrazinamide
rpsA 1834669 c.1128G>C synonymous_variant 0.26 pyrazinamide
rpsA 1834726 c.1185C>A synonymous_variant 0.3 pyrazinamide
rpsA 1834732 c.1191T>C synonymous_variant 0.32 pyrazinamide
rpsA 1834733 p.Ala398Pro missense_variant 0.32 pyrazinamide
rpsA 1834753 c.1212T>C synonymous_variant 0.39 pyrazinamide
rpsA 1834765 c.1224A>G synonymous_variant 0.32 pyrazinamide
rpsA 1834780 c.1239A>G synonymous_variant 0.36 pyrazinamide
rpsA 1834786 c.1245A>G synonymous_variant 0.34 pyrazinamide
rpsA 1834789 c.1248T>C synonymous_variant 0.34 pyrazinamide
rpsA 1834792 c.1251G>C synonymous_variant 0.31 pyrazinamide
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
ndh 2102233 c.810G>A synonymous_variant 0.21 ethionamide Not assoc w R - Interim
delamanid
isoniazid Not assoc w R - Interim
ndh 2102242 c.801G>A synonymous_variant 0.21 ethionamide
delamanid
isoniazid
ndh 2102990 p.Val18Ala missense_variant 0.93 ethionamide Uncertain significance
delamanid Uncertain significance
isoniazid Not assoc w R
katG 2155113 c.999C>G synonymous_variant 0.17 isoniazid
katG 2155120 p.Ser331Thr missense_variant 0.15 isoniazid
PPE35 2169840 p.Gly258Asp missense_variant 0.95 pyrazinamide Not assoc w R
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
kasA 2517947 c.-168C>T upstream_gene_variant 0.31 isoniazid
kasA 2517974 c.-141T>C upstream_gene_variant 0.36 isoniazid
kasA 2517989 c.-126T>C upstream_gene_variant 0.29 isoniazid
kasA 2517992 c.-123C>G upstream_gene_variant 0.28 isoniazid
kasA 2518019 c.-96A>G upstream_gene_variant 0.17 isoniazid
kasA 2518025 c.-90G>C upstream_gene_variant 0.17 isoniazid
kasA 2518475 c.361A>C synonymous_variant 0.27 isoniazid
kasA 2518480 c.366T>C synonymous_variant 0.28 isoniazid
kasA 2518483 c.369C>G synonymous_variant 0.28 isoniazid
kasA 2518504 c.390T>C synonymous_variant 0.32 isoniazid
kasA 2518506 p.Ala131Glu missense_variant 0.33 isoniazid
kasA 2518519 c.405G>C synonymous_variant 0.32 isoniazid
kasA 2518528 c.414C>G synonymous_variant 0.35 isoniazid
kasA 2518540 c.426T>G synonymous_variant 0.42 isoniazid
kasA 2518561 c.447T>C synonymous_variant 0.35 isoniazid
kasA 2518567 c.453G>C synonymous_variant 0.32 isoniazid
kasA 2518591 c.477G>C synonymous_variant 0.33 isoniazid
kasA 2518642 c.528A>G synonymous_variant 0.33 isoniazid
kasA 2518663 c.549T>C synonymous_variant 0.33 isoniazid
kasA 2518672 c.558G>C synonymous_variant 0.35 isoniazid
kasA 2518687 c.573C>T synonymous_variant 0.29 isoniazid
kasA 2518696 c.582C>G synonymous_variant 0.24 isoniazid
kasA 2518702 c.588C>T synonymous_variant 0.28 isoniazid
kasA 2518816 c.702C>A synonymous_variant 0.27 isoniazid
kasA 2518822 c.708C>G synonymous_variant 0.27 isoniazid
kasA 2518825 c.711T>C synonymous_variant 0.3 isoniazid
kasA 2518855 c.741C>G synonymous_variant 0.25 isoniazid
kasA 2518864 c.750G>C synonymous_variant 0.25 isoniazid
kasA 2518879 c.765A>G synonymous_variant 0.22 isoniazid
kasA 2518885 c.771T>C synonymous_variant 0.24 isoniazid
kasA 2518888 c.774C>T synonymous_variant 0.25 isoniazid
kasA 2518898 c.784T>C synonymous_variant 0.23 isoniazid
kasA 2518906 c.792A>G synonymous_variant 0.23 isoniazid
ahpC 2726612 c.420C>G synonymous_variant 0.15 isoniazid
ahpC 2726638 p.Ala149Val missense_variant 0.23 isoniazid
ahpC 2726645 c.453C>G synonymous_variant 0.24 isoniazid
ahpC 2726657 c.465A>C synonymous_variant 0.24 isoniazid Not assoc w R - Interim
ahpC 2726669 p.Asp159Glu missense_variant 0.23 isoniazid
ahpC 2726672 c.480G>A synonymous_variant 0.23 isoniazid Not assoc w R - Interim
ahpC 2726681 c.489A>G synonymous_variant 0.21 isoniazid
Rv2477c 2782528 c.1515G>C synonymous_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782537 c.1506T>G synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782540 c.1503T>C synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782549 c.1494T>C synonymous_variant 0.18 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2782981 c.1062G>C synonymous_variant 0.31 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782984 c.1059T>C synonymous_variant 0.31 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783002 c.1041T>C synonymous_variant 0.35 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783008 c.1035C>G synonymous_variant 0.33 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783013 c.1030T>C synonymous_variant 0.38 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783015 p.Ser343Thr missense_variant 0.38 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783020 c.1023G>C synonymous_variant 0.38 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783040 p.Ala335Thr missense_variant 0.36 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
kanamycin Uncertain significance
rifampicin Uncertain significance
amikacin Uncertain significance
Rv2477c 2783041 c.1002C>G synonymous_variant 0.34 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783059 c.984T>C synonymous_variant 0.37 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783062 c.981C>G synonymous_variant 0.38 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783068 p.Asp325Glu missense_variant 0.38 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783077 c.966T>C synonymous_variant 0.36 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783092 c.951A>G synonymous_variant 0.38 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783095 c.948C>G synonymous_variant 0.41 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R
amikacin Not assoc w R - Interim
Rv2477c 2783116 c.927T>C synonymous_variant 0.39 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783140 c.903C>G synonymous_variant 0.38 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783158 c.885A>G synonymous_variant 0.36 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783185 c.858G>C synonymous_variant 0.36 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783194 c.849A>G synonymous_variant 0.37 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783203 c.840C>T synonymous_variant 0.35 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783224 c.819C>G synonymous_variant 0.35 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783230 c.813T>C synonymous_variant 0.38 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783235 c.808T>C synonymous_variant 0.37 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783243 p.Thr267Ser missense_variant 0.4 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783247 c.796T>C synonymous_variant 0.4 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783254 c.789A>G synonymous_variant 0.35 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783263 c.780G>C synonymous_variant 0.31 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783278 c.765A>G synonymous_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783287 c.756C>G synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783290 c.753G>C synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783751 p.Ile98Val missense_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783758 p.Asp95Glu missense_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783761 c.282G>C synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783766 p.Met93Leu missense_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783920 c.123G>C synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783926 c.117C>T synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783953 c.90G>A synonymous_variant 0.25 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2784405 c.-363T>C upstream_gene_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2784428 c.-386T>C upstream_gene_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2784429 c.-387A>G upstream_gene_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2784432 c.-390A>C upstream_gene_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2784455 c.-413A>C upstream_gene_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2784456 c.-414A>C upstream_gene_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
ribD 2987560 p.Ala241Asp missense_variant 0.96 para-aminosalicylic_acid
Rv2752c 3066040 p.Gly51Thr missense_variant 0.2 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066042 c.150T>C synonymous_variant 0.19 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066050 p.Leu48Met missense_variant 0.22 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066054 c.138T>G synonymous_variant 0.21 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066066 c.126T>C synonymous_variant 0.21 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066075 c.117A>G synonymous_variant 0.21 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
thyX 3067304 c.642A>G synonymous_variant 0.22 para-aminosalicylic_acid
thyX 3067316 c.630A>G synonymous_variant 0.18 para-aminosalicylic_acid
thyX 3067355 c.591A>C synonymous_variant 0.24 para-aminosalicylic_acid
thyA 3073839 c.633T>C synonymous_variant 0.21 para-aminosalicylic_acid
thyA 3073872 c.598_600delATCinsGG frameshift_variant&missense_variant 0.25 para-aminosalicylic_acid
thyA 3073878 c.594G>A synonymous_variant 0.26 para-aminosalicylic_acid
thyA 3073892 c.580T>C synonymous_variant 0.24 para-aminosalicylic_acid
thyA 3073893 c.579C>G synonymous_variant 0.22 para-aminosalicylic_acid
thyA 3073989 c.483T>C synonymous_variant 0.25 para-aminosalicylic_acid
thyA 3074001 c.471C>G synonymous_variant 0.24 para-aminosalicylic_acid
thyA 3074004 c.468T>C synonymous_variant 0.24 para-aminosalicylic_acid
ald 3086788 c.-32T>C upstream_gene_variant 0.97 cycloserine
Rv3083 3448608 c.105G>A synonymous_variant 1.0 ethionamide Not assoc w R - Interim
Rv3236c 3612621 c.496T>C synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
Rv3236c 3612628 c.489G>C synonymous_variant 0.17 pyrazinamide
Rv3236c 3612643 c.474A>G synonymous_variant 0.22 pyrazinamide
Rv3236c 3612665 p.Val151Ala missense_variant 0.69 pyrazinamide Not assoc w R
Rv3236c 3612667 c.450T>G synonymous_variant 0.25 pyrazinamide
Rv3236c 3612673 c.444G>C synonymous_variant 0.27 pyrazinamide
Rv3236c 3612676 c.441A>G synonymous_variant 0.27 pyrazinamide
Rv3236c 3612685 c.432C>T synonymous_variant 0.28 pyrazinamide
Rv3236c 3612694 c.423T>C synonymous_variant 0.27 pyrazinamide Not assoc w R - Interim
lpqB 3624094 c.817A>C synonymous_variant 0.31 bedaquiline
rifampicin
lpqB 3624100 c.811T>C synonymous_variant 0.21 bedaquiline
rifampicin
lpqB 3624107 c.804C>T synonymous_variant 0.27 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3624119 c.792C>G synonymous_variant 0.25 bedaquiline
rifampicin
lpqB 3624124 p.Leu263Val missense_variant 0.26 bedaquiline
rifampicin
lpqB 3624125 c.786A>G synonymous_variant 0.26 bedaquiline
rifampicin
lpqB 3624389 c.522C>G synonymous_variant 0.18 bedaquiline
rifampicin
lpqB 3624401 c.510C>T synonymous_variant 0.21 bedaquiline
rifampicin
lpqB 3624407 c.504C>G synonymous_variant 0.19 bedaquiline
rifampicin
lpqB 3624426 p.Glu162Ala missense_variant 0.16 bedaquiline
rifampicin
lpqB 3624452 c.459T>C synonymous_variant 0.2 bedaquiline
rifampicin
lpqB 3624464 c.447A>G synonymous_variant 0.2 bedaquiline
rifampicin
lpqB 3624470 c.441T>C synonymous_variant 0.17 bedaquiline
rifampicin
lpqB 3624486 p.Asp142Gly missense_variant 0.15 bedaquiline Uncertain significance
rifampicin Not assoc w R
mtrB 3625065 p.Met517Leu missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
mtrB 3625592 p.Ser341Asn missense_variant 0.17 bedaquiline
rifampicin
lpqB 3625594 c.-684T>C upstream_gene_variant 0.17 bedaquiline
rifampicin
lpqB 3625602 c.-692T>C upstream_gene_variant 0.22 bedaquiline
rifampicin
lpqB 3625612 c.-702G>C upstream_gene_variant 0.23 bedaquiline
rifampicin
mtrB 3625616 p.Arg333Ala missense_variant 0.21 bedaquiline
rifampicin
lpqB 3625624 c.-714C>G upstream_gene_variant 0.26 bedaquiline
rifampicin
lpqB 3625627 c.-717C>T upstream_gene_variant 0.29 bedaquiline
rifampicin
lpqB 3625648 c.-738T>C upstream_gene_variant 0.25 bedaquiline
rifampicin
mtrB 3625656 c.958T>C synonymous_variant 0.25 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
lpqB 3625663 c.-753G>C upstream_gene_variant 0.24 bedaquiline
rifampicin
lpqB 3625669 c.-759G>C upstream_gene_variant 0.22 bedaquiline
rifampicin
lpqB 3625687 c.-777G>C upstream_gene_variant 0.25 bedaquiline
rifampicin
lpqB 3625696 c.-786A>G upstream_gene_variant 0.29 bedaquiline
rifampicin
mtrB 3625705 c.909C>G synonymous_variant 0.24 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625714 c.-804C>T upstream_gene_variant 0.27 bedaquiline
rifampicin
mtrB 3625720 c.894G>C synonymous_variant 0.26 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625729 c.885A>G synonymous_variant 0.26 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625735 c.879C>A synonymous_variant 0.29 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625750 c.864G>A synonymous_variant 0.36 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625755 p.Ala287Thr missense_variant 0.34 bedaquiline
rifampicin Uncertain significance
mtrB 3625762 c.852A>G synonymous_variant 0.34 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625765 c.849C>G synonymous_variant 0.35 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625797 p.Val273Met missense_variant 0.35 bedaquiline Uncertain significance
rifampicin Uncertain significance
mtrB 3625806 c.808A>C synonymous_variant 0.33 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625837 c.777C>G synonymous_variant 0.32 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625840 c.-930A>G upstream_gene_variant 0.29 bedaquiline
rifampicin
mtrB 3625852 c.762A>G synonymous_variant 0.23 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625864 c.-954T>G upstream_gene_variant 0.16 bedaquiline
rifampicin
mtrA 3626759 c.591T>C synonymous_variant 0.18 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626783 c.-170C>G upstream_gene_variant 0.16 bedaquiline
rifampicin
mtrA 3626786 c.564A>G synonymous_variant 0.16 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3626804 c.546A>G synonymous_variant 0.16 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3626912 c.438T>C synonymous_variant 0.15 bedaquiline
rifampicin Not assoc w R - Interim
rpoA 3877503 c.1005G>C synonymous_variant 0.21 rifampicin
rpoA 3877507 p.Gly334Ala missense_variant 0.19 rifampicin
rpoA 3877515 c.993G>C synonymous_variant 0.19 rifampicin
rpoA 3877542 c.966C>T synonymous_variant 0.19 rifampicin
rpoA 3877553 p.Glu319Gln missense_variant 0.28 rifampicin
rpoA 3877557 c.951C>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoA 3877587 c.921A>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoA 3877692 c.816G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoA 3877770 c.738A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3877776 c.732T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3877839 c.669G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoA 3877857 c.651G>A synonymous_variant 0.28 rifampicin
rpoA 3877866 c.642G>C synonymous_variant 0.27 rifampicin
rpoA 3877872 c.636C>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoA 3877875 c.633T>G synonymous_variant 0.23 rifampicin
rpoA 3877899 p.Ser203Thr missense_variant 0.24 rifampicin
rpoA 3877905 c.603A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoA 3877908 p.Asn200Ser missense_variant 0.23 rifampicin
rpoA 3877962 c.546G>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoA 3877986 c.522G>C synonymous_variant 0.17 rifampicin
rpoA 3877989 c.519A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3878001 c.507A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3878040 c.468T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoA 3878046 c.462T>C synonymous_variant 0.15 rifampicin
rpoA 3878070 c.438T>C synonymous_variant 0.15 rifampicin
rpoA 3878082 c.426T>C synonymous_variant 0.2 rifampicin
rpoA 3878094 c.414C>G synonymous_variant 0.24 rifampicin
rpoA 3878100 c.408C>G synonymous_variant 0.28 rifampicin
rpoA 3878103 c.405A>G synonymous_variant 0.27 rifampicin
rpoA 3878106 c.402G>C synonymous_variant 0.28 rifampicin
rpoA 3878118 c.390T>C synonymous_variant 0.3 rifampicin
rpoA 3878141 p.Met123Leu missense_variant 0.26 rifampicin Uncertain significance
rpoA 3878142 p.Gly122Glu missense_variant 0.26 rifampicin
rpoA 3878169 c.339G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoA 3878202 c.306G>C synonymous_variant 0.21 rifampicin
rpoA 3878217 c.291A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3878271 c.237T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoA 3878313 c.195G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3878322 c.186A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoA 3878331 c.177A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoA 3878334 c.174T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoA 3878337 c.171T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3878346 c.162T>C synonymous_variant 0.2 rifampicin
rpoA 3878391 c.117T>C synonymous_variant 0.16 rifampicin
rpoA 3878396 c.112C>T synonymous_variant 0.16 rifampicin
rpoA 3879121 c.-614T>G upstream_gene_variant 0.19 rifampicin
clpC1 4038293 c.2412G>C synonymous_variant 0.21 pyrazinamide
clpC1 4038302 c.2403C>G synonymous_variant 0.21 pyrazinamide
clpC1 4038308 c.2395_2397delGTGinsAC frameshift_variant&missense_variant 0.21 pyrazinamide
clpC1 4038317 c.2388G>C synonymous_variant 0.22 pyrazinamide
clpC1 4038347 c.2358G>C synonymous_variant 0.2 pyrazinamide
clpC1 4038498 p.Ser736Thr missense_variant 0.16 pyrazinamide
clpC1 4038530 p.Glu725Asp missense_variant 0.22 pyrazinamide
clpC1 4038536 c.2169C>T synonymous_variant 0.22 pyrazinamide Not assoc w R - Interim
clpC1 4038596 c.2109A>G synonymous_variant 0.26 pyrazinamide
clpC1 4038623 c.2082A>G synonymous_variant 0.21 pyrazinamide
clpC1 4038640 p.Asp689Asn missense_variant 0.22 pyrazinamide
clpC1 4038653 c.2052C>T synonymous_variant 0.2 pyrazinamide
clpC1 4038658 p.Lys683Gln missense_variant 0.19 pyrazinamide
clpC1 4038661 p.Ser682Thr missense_variant 0.19 pyrazinamide
clpC1 4038662 c.2043T>C synonymous_variant 0.2 pyrazinamide
clpC1 4038671 c.2034T>C synonymous_variant 0.18 pyrazinamide
clpC1 4038683 c.2022T>C synonymous_variant 0.18 pyrazinamide Not assoc w R - Interim
clpC1 4038740 c.1965G>C synonymous_variant 0.23 pyrazinamide
clpC1 4038755 c.1950G>C synonymous_variant 0.24 pyrazinamide
clpC1 4038773 c.1932T>C synonymous_variant 0.29 pyrazinamide
clpC1 4038782 c.1923G>C synonymous_variant 0.29 pyrazinamide
clpC1 4038790 c.1915C>T synonymous_variant 0.28 pyrazinamide Not assoc w R - Interim
clpC1 4038812 c.1893T>C synonymous_variant 0.33 pyrazinamide
clpC1 4038815 c.1890G>T synonymous_variant 0.33 pyrazinamide
clpC1 4038953 c.1752A>G synonymous_variant 0.18 pyrazinamide
clpC1 4038956 c.1749T>C synonymous_variant 0.2 pyrazinamide
clpC1 4038965 c.1740T>C synonymous_variant 0.21 pyrazinamide
clpC1 4038971 c.1734T>C synonymous_variant 0.2 pyrazinamide
clpC1 4038974 c.1731T>C synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
clpC1 4038989 c.1716T>C synonymous_variant 0.22 pyrazinamide
clpC1 4038997 c.1708T>C synonymous_variant 0.24 pyrazinamide Not assoc w R - Interim
clpC1 4039022 c.1683A>G synonymous_variant 0.19 pyrazinamide
clpC1 4039073 c.1632C>G synonymous_variant 0.23 pyrazinamide
clpC1 4039085 c.1620A>G synonymous_variant 0.22 pyrazinamide
clpC1 4039090 c.1615C>T synonymous_variant 0.21 pyrazinamide
clpC1 4039145 c.1560G>C synonymous_variant 0.14 pyrazinamide
clpC1 4039178 c.1527G>C synonymous_variant 0.17 pyrazinamide
clpC1 4039183 c.1522T>C synonymous_variant 0.18 pyrazinamide
clpC1 4039187 c.1518G>C synonymous_variant 0.16 pyrazinamide
clpC1 4039190 c.1515C>G synonymous_variant 0.16 pyrazinamide
clpC1 4039208 c.1497C>G synonymous_variant 0.19 pyrazinamide
clpC1 4039769 c.936C>G synonymous_variant 0.17 pyrazinamide
clpC1 4040105 c.600C>G synonymous_variant 0.32 pyrazinamide
clpC1 4040267 c.438A>G synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
clpC1 4040273 c.432T>C synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
clpC1 4040354 c.351A>G synonymous_variant 0.38 pyrazinamide
clpC1 4040363 c.342A>C synonymous_variant 0.37 pyrazinamide
clpC1 4040369 c.336C>G synonymous_variant 0.37 pyrazinamide
clpC1 4040380 c.325T>C synonymous_variant 0.26 pyrazinamide
clpC1 4040387 c.318A>G synonymous_variant 0.21 pyrazinamide
clpC1 4040393 c.312G>C synonymous_variant 0.21 pyrazinamide Not assoc w R - Interim
clpC1 4040465 c.240T>C synonymous_variant 0.26 pyrazinamide
clpC1 4040471 c.234T>C synonymous_variant 0.25 pyrazinamide Not assoc w R - Interim
clpC1 4040477 c.228G>A synonymous_variant 0.24 pyrazinamide
clpC1 4040480 c.225T>C synonymous_variant 0.26 pyrazinamide Not assoc w R - Interim
clpC1 4040522 c.183T>C synonymous_variant 0.24 pyrazinamide Not assoc w R - Interim
clpC1 4040528 c.177G>C synonymous_variant 0.25 pyrazinamide
clpC1 4040531 c.174T>C synonymous_variant 0.25 pyrazinamide
clpC1 4040534 c.171A>G synonymous_variant 0.25 pyrazinamide Not assoc w R - Interim
clpC1 4040546 c.159G>C synonymous_variant 0.19 pyrazinamide
clpC1 4040644 c.61A>C synonymous_variant 0.2 pyrazinamide
clpC1 4040654 c.51G>A synonymous_variant 0.21 pyrazinamide
clpC1 4040657 c.48T>G synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
clpC1 4040662 c.43C>T synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
clpC1 4040699 c.6C>T synonymous_variant 0.26 pyrazinamide
clpC1 4040711 c.-7G>A upstream_gene_variant 0.23 pyrazinamide
glpK 4138579 c.1177C>T synonymous_variant 0.69 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4138583 c.1173G>C synonymous_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138586 c.1170C>T synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138606 c.1150T>C synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139597 c.159C>G synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139630 c.126C>T synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
embC 4238963 c.-900C>T upstream_gene_variant 0.86 ethambutol Not assoc w R
embC 4240819 c.957A>G synonymous_variant 0.48 ethambutol
embC 4240831 c.969T>G synonymous_variant 0.54 ethambutol
embC 4240867 c.1005T>G synonymous_variant 0.57 ethambutol
embC 4240870 c.1008T>C synonymous_variant 0.59 ethambutol
embC 4240979 p.Thr373Gln missense_variant 0.29 ethambutol
embC 4240983 p.Ser374Asn missense_variant 0.29 ethambutol
embC 4240990 c.1128A>G synonymous_variant 0.33 ethambutol
embC 4240996 c.1134G>C synonymous_variant 0.39 ethambutol
embC 4241017 c.1155T>C synonymous_variant 0.44 ethambutol
embC 4241023 c.1161T>G synonymous_variant 0.4 ethambutol
embC 4241026 c.1164C>G synonymous_variant 0.38 ethambutol
embC 4241104 c.1242G>A synonymous_variant 0.29 ethambutol Not assoc w R - Interim
embC 4241107 c.1245G>C synonymous_variant 0.28 ethambutol
embC 4241137 c.1275G>C synonymous_variant 0.36 ethambutol
embC 4241140 c.1278A>G synonymous_variant 0.35 ethambutol Not assoc w R - Interim
embC 4241141 p.Ile427Val missense_variant 0.38 ethambutol Uncertain significance
embC 4241158 c.1296T>C synonymous_variant 0.35 ethambutol
embC 4241161 c.1299C>G synonymous_variant 0.35 ethambutol Not assoc w R - Interim
embC 4241162 c.1300T>C synonymous_variant 0.35 ethambutol
embC 4242643 c.2781C>T synonymous_variant 0.88 ethambutol Not assoc w R
embA 4245137 c.1905T>C synonymous_variant 0.21 ethambutol
embA 4245149 c.1917C>G synonymous_variant 0.24 ethambutol
embA 4245182 c.1950T>C synonymous_variant 0.2 ethambutol
embA 4245194 c.1962G>C synonymous_variant 0.19 ethambutol
embA 4245198 p.Leu656Ile missense_variant 0.19 ethambutol
embB 4245830 c.-684G>C upstream_gene_variant 0.24 ethambutol
embB 4245845 c.-669T>G upstream_gene_variant 0.27 ethambutol
embB 4245848 c.-666C>G upstream_gene_variant 0.26 ethambutol
embB 4247389 c.876C>G synonymous_variant 0.22 ethambutol
embB 4247395 c.882C>G synonymous_variant 0.21 ethambutol
embB 4247401 c.888T>C synonymous_variant 0.2 ethambutol
embB 4247464 c.951C>G synonymous_variant 0.19 ethambutol
embB 4247470 c.957T>C synonymous_variant 0.22 ethambutol
embB 4248035 p.Val508Ile missense_variant 0.35 ethambutol
embB 4248041 p.Ala510Thr missense_variant 0.32 ethambutol Uncertain significance
embB 4248044 p.Lys511Ala missense_variant 0.33 ethambutol
embB 4248052 c.1539G>A synonymous_variant 0.35 ethambutol
embB 4248055 c.1542G>A synonymous_variant 0.35 ethambutol Not assoc w R - Interim
embB 4248064 c.1551G>C synonymous_variant 0.46 ethambutol Not assoc w R - Interim
embB 4248070 c.1557T>C synonymous_variant 0.44 ethambutol
embB 4248085 c.1572T>C synonymous_variant 0.45 ethambutol
embB 4248097 c.1584C>G synonymous_variant 0.54 ethambutol
embB 4248118 c.1605T>C synonymous_variant 0.61 ethambutol
embB 4248127 c.1614G>C synonymous_variant 0.5 ethambutol
embB 4248133 c.1620C>G synonymous_variant 0.48 ethambutol
embB 4248142 c.1629T>C synonymous_variant 0.48 ethambutol
embB 4248143 c.1630T>C synonymous_variant 0.5 ethambutol
embB 4248157 c.1644A>G synonymous_variant 0.43 ethambutol Not assoc w R - Interim
embB 4248206 c.1693_1695delAGCinsGG frameshift_variant&missense_variant 0.33 ethambutol
aftB 4268384 p.Leu151Phe missense_variant 0.94 ethambutol Uncertain significance
aftB 4269183 c.-347T>C upstream_gene_variant 0.33 ethambutol
aftB 4269201 c.-365A>G upstream_gene_variant 0.37 ethambutol
ubiA 4269841 c.-8G>A upstream_gene_variant 0.89 ethambutol Uncertain significance
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 capreomycin
amikacin
kanamycin