TB-Profiler result

Run: ERR4817735
Summary

Run ID: ERR4817735

Sample name:

Date: 2024-10-05T00:34:01.216897

Number of reads: 2100820

Percentage reads mapped: 69.56

Median coverage: 46.0

Strain: lineage4.8

Spoligotype:

Drug-resistance: Other

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage4 Euro-American None 0.97
lineage4.8 Euro-American (mainly T) RD219 0.97
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol embB p.His312Arg Mutation from literature
pyrazinamide
streptomycin rrs n.888G>A Uncertain significance Mutation from literature
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
rrs 1472733 n.888G>A non_coding_transcript_exon_variant 0.57 streptomycin Uncertain significance Mutation from literature
embB 4247448 p.His312Arg missense_variant 0.16 ethambutol Mutation from literature
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
dnaA 1014 c.1014C>G synonymous_variant 0.15 isoniazid
dnaA 1024 c.1024T>C synonymous_variant 0.19 isoniazid
dnaA 1038 c.1038A>T synonymous_variant 0.18 isoniazid
dnaA 1041 c.1041G>A synonymous_variant 0.18 isoniazid
dnaA 1047 c.1047A>G synonymous_variant 0.2 isoniazid
dnaA 1068 c.1068T>C synonymous_variant 0.22 isoniazid
dnaA 1098 c.1098A>G synonymous_variant 0.17 isoniazid
dnaA 1104 c.1104T>C synonymous_variant 0.16 isoniazid
dnaA 1110 c.1110T>C synonymous_variant 0.16 isoniazid
gyrB 5078 c.-162_-161insG upstream_gene_variant 0.85 levofloxacin
moxifloxacin
gyrB 6196 c.957C>T synonymous_variant 0.35 levofloxacin
moxifloxacin
gyrB 6250 c.1011A>G synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6256 c.1017G>A synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrB 6268 c.1029C>G synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrB 6280 c.1041T>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrB 6286 c.1047T>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrB 6289 c.1050C>T synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrB 6292 c.1053G>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrB 6307 c.1068T>G synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6319 c.1080G>C synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 6670 c.-632G>C upstream_gene_variant 0.21 levofloxacin
moxifloxacin
gyrA 6673 c.-629A>C upstream_gene_variant 0.23 levofloxacin
moxifloxacin
gyrA 6676 c.-626T>G upstream_gene_variant 0.23 levofloxacin
moxifloxacin
gyrA 6700 c.-602T>C upstream_gene_variant 0.21 levofloxacin
moxifloxacin
gyrB 6841 c.1602T>C synonymous_variant 0.25 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6844 c.-458T>C upstream_gene_variant 0.23 levofloxacin
moxifloxacin
gyrA 6967 c.-335T>C upstream_gene_variant 0.27 levofloxacin
moxifloxacin
gyrA 6973 c.-329G>C upstream_gene_variant 0.33 levofloxacin
moxifloxacin
gyrA 6982 c.-320A>C upstream_gene_variant 0.29 levofloxacin
moxifloxacin
gyrA 7006 c.-296T>C upstream_gene_variant 0.27 levofloxacin
moxifloxacin
gyrA 7007 c.-295C>T upstream_gene_variant 0.26 levofloxacin
moxifloxacin
gyrA 7010 c.-292C>T upstream_gene_variant 0.25 levofloxacin
moxifloxacin
gyrA 7015 c.-287G>A upstream_gene_variant 0.25 levofloxacin
moxifloxacin
gyrA 7018 c.-284G>A upstream_gene_variant 0.29 levofloxacin
moxifloxacin
gyrB 7023 p.Leu595Gln missense_variant 0.27 levofloxacin
moxifloxacin
gyrA 7033 c.-269G>C upstream_gene_variant 0.29 levofloxacin
moxifloxacin
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7391 c.90C>T synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7394 c.93T>C synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7427 c.126G>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 7442 c.141G>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 7451 c.150C>G synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 7457 c.156T>C synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrA 7475 c.174A>G synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7477 p.Met59Thr missense_variant 0.78 levofloxacin
moxifloxacin
gyrA 7480 p.Phe60Tyr missense_variant 0.21 levofloxacin
moxifloxacin
gyrA 7484 c.183T>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 7490 c.189C>G synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 7523 c.222C>G synonymous_variant 0.25 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7532 c.231T>G synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7541 c.240C>G synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7547 c.246C>T synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7571 c.270G>C synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7585 p.Ser95Thr missense_variant 0.23 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7595 c.294C>G synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 7601 c.300C>G synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7607 c.306C>T synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7622 c.321C>T synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 7625 c.324G>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 7631 c.330G>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 7637 c.336C>G synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 7763 c.462T>C synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7775 c.474C>A synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 7781 c.480G>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 7784 c.483A>G synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 7790 c.489G>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 7793 c.492G>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 7796 c.495G>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 7799 c.498A>G synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7814 c.513C>G synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7823 c.522G>C synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 7832 c.531G>T synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 7835 c.534A>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8129 c.828T>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8135 c.834C>G synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8156 c.855T>C synonymous_variant 0.32 levofloxacin
moxifloxacin
gyrA 8168 c.867A>G synonymous_variant 0.31 levofloxacin
moxifloxacin
gyrA 8177 c.876A>C synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrA 8198 c.897T>C synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8207 c.906T>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8219 c.918T>C synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8225 c.924T>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8234 c.933T>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8237 c.936A>G synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8247 p.Ile316Val missense_variant 0.21 levofloxacin
moxifloxacin
gyrA 8294 c.993T>C synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8324 c.1023T>C synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 8330 c.1029C>G synonymous_variant 0.3 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8339 c.1038A>G synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 8340 p.Ala347Ser missense_variant 0.25 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8372 c.1071G>C synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 8375 c.1074G>C synonymous_variant 0.31 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 8382 p.Leu361Met missense_variant 0.35 levofloxacin
moxifloxacin
gyrA 8387 c.1086C>T synonymous_variant 0.33 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8391 p.Tyr364His missense_variant 0.27 levofloxacin
moxifloxacin
gyrA 8399 c.1098T>G synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 8401 p.Asp367Ala missense_variant 0.26 levofloxacin
moxifloxacin
gyrA 8405 c.1104C>T synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 8619 c.1318_1320delTTGinsCTA synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8624 c.1323G>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8636 c.1335A>C synonymous_variant 0.25 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8642 c.1341A>G synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8672 c.1371A>G synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8891 c.1590G>A synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8897 c.1596T>C synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8903 c.1602T>C synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8933 c.1632G>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8939 c.1638T>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8942 c.1641G>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8946 c.1645_1647delTTGinsCTC synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9323 c.2022C>G synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9335 c.2034G>C synonymous_variant 0.16 levofloxacin
moxifloxacin
Rv0010c 13788 c.-230C>G upstream_gene_variant 0.97 isoniazid
fgd1 490827 c.45C>T synonymous_variant 0.16 pretomanid
delamanid
clofazimine
fgd1 490848 c.66A>G synonymous_variant 0.17 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R - Interim
fgd1 490851 c.69A>T synonymous_variant 0.17 pretomanid
delamanid
clofazimine
fgd1 490868 p.Ala29Gly missense_variant 0.19 pretomanid
delamanid
clofazimine
mshA 574672 c.-676C>T upstream_gene_variant 0.14 isoniazid
ethionamide
mshA 574694 c.-654C>G upstream_gene_variant 0.16 isoniazid
ethionamide
mshA 575674 c.327G>C synonymous_variant 0.17 isoniazid
ethionamide
mshA 575812 c.465C>T synonymous_variant 0.26 isoniazid
ethionamide
mshA 575821 c.474G>C synonymous_variant 0.23 isoniazid
ethionamide
mshA 575824 c.477T>G synonymous_variant 0.24 isoniazid
ethionamide
mshA 575830 c.483C>G synonymous_variant 0.26 isoniazid
ethionamide
mshA 575833 c.486C>G synonymous_variant 0.26 isoniazid
ethionamide
mshA 575845 c.498C>T synonymous_variant 0.26 isoniazid Not assoc w R - Interim
ethionamide
mshA 575884 c.537G>C synonymous_variant 0.23 isoniazid
ethionamide
mshA 575887 c.540G>C synonymous_variant 0.23 isoniazid
ethionamide
mshA 575893 c.546C>G synonymous_variant 0.21 isoniazid
ethionamide
mshA 575896 c.549G>C synonymous_variant 0.21 isoniazid
ethionamide
ccsA 620362 p.Ala158Thr missense_variant 0.15 kanamycin
capreomycin
amikacin
ccsA 620373 c.483C>G synonymous_variant 0.16 kanamycin
capreomycin
amikacin
ccsA 620376 c.486G>C synonymous_variant 0.19 kanamycin
capreomycin
amikacin
ccsA 620389 c.499C>T synonymous_variant 0.16 kanamycin
capreomycin
amikacin
ccsA 620412 c.522T>C synonymous_variant 0.19 kanamycin
capreomycin
amikacin
ccsA 620415 c.525T>C synonymous_variant 0.19 kanamycin Not assoc w R - Interim
capreomycin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv0565c 656265 c.1204_1205delAC frameshift_variant 1.0 ethionamide Uncertain significance
Rv0565c 656493 c.978C>G synonymous_variant 0.17 ethionamide
Rv0565c 656502 c.969C>T synonymous_variant 0.16 ethionamide
Rv0565c 656511 c.960T>C synonymous_variant 0.15 ethionamide Not assoc w R - Interim
Rv0565c 657259 p.Tyr71Phe missense_variant 0.3 ethionamide
Rv0565c 657261 c.210C>G synonymous_variant 0.29 ethionamide
Rv0565c 657264 c.207T>C synonymous_variant 0.32 ethionamide
Rv0565c 657267 c.204G>C synonymous_variant 0.29 ethionamide
Rv0565c 657300 c.171C>G synonymous_variant 0.35 ethionamide
Rv0565c 657318 c.153T>C synonymous_variant 0.21 ethionamide
Rv0565c 657324 c.147C>G synonymous_variant 0.2 ethionamide
Rv0565c 657327 c.144C>G synonymous_variant 0.16 ethionamide
hadA 732295 c.366G>C synonymous_variant 0.16 isoniazid
hadA 732305 p.Ile126Val missense_variant 0.17 isoniazid
hadA 732308 p.Val127Ile missense_variant 0.17 isoniazid
hadA 732321 p.Glu131Ala missense_variant 0.16 isoniazid
hadA 732329 p.Leu134Val missense_variant 0.16 isoniazid Uncertain significance
hadA 732337 c.408G>A synonymous_variant 0.18 isoniazid
hadA 732378 c.450_452dupAGA disruptive_inframe_insertion 0.24 isoniazid
hadA 732396 p.Gly156Ala missense_variant 0.22 isoniazid
hadA 732398 p.Ala157Thr missense_variant 0.22 isoniazid
nusG 734442 c.189G>A synonymous_variant 0.2 rifampicin
nusG 734451 c.198G>C synonymous_variant 0.2 rifampicin
nusG 734457 c.204C>G synonymous_variant 0.21 rifampicin
nusG 734472 c.219T>C synonymous_variant 0.26 rifampicin
nusG 734475 c.222T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
nusG 734532 c.279A>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
nusG 734541 c.288A>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
nusG 734556 c.303C>T synonymous_variant 0.3 rifampicin
nusG 734559 c.306T>C synonymous_variant 0.28 rifampicin
nusG 734580 c.327T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
nusG 734658 c.405A>G synonymous_variant 1.0 rifampicin Not assoc w R
nusG 734841 c.588G>C synonymous_variant 0.17 rifampicin
nusG 734847 c.594T>C synonymous_variant 0.17 rifampicin
nusG 734850 c.597C>G synonymous_variant 0.18 rifampicin
nusG 734853 c.600A>G synonymous_variant 0.18 rifampicin
nusG 734854 c.601T>C synonymous_variant 0.18 rifampicin
nusG 734882 p.Ala210Gly missense_variant 0.18 rifampicin
nusG 734886 c.633A>G synonymous_variant 0.17 rifampicin
rpoB 760181 c.375T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760184 c.378A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760340 c.534G>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760406 c.600G>C synonymous_variant 0.19 rifampicin
rpoB 760522 p.Ser239Asn missense_variant 0.22 rifampicin Uncertain significance
rpoB 760532 c.726T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760533 p.Val243Thr missense_variant 0.21 rifampicin
rpoB 760541 c.735G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 760547 c.741G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 760563 p.Arg253Met missense_variant 0.31 rifampicin Uncertain significance
rpoB 760591 p.Val262Ala missense_variant 0.3 rifampicin
rpoB 760655 c.849A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760661 c.855A>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760670 c.864G>C synonymous_variant 0.21 rifampicin
rpoB 760674 c.868T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760679 c.873A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760886 c.1080A>G synonymous_variant 0.24 rifampicin
rpoB 760946 c.1140A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761129 c.1323G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761132 c.1326G>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761133 c.1327T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761150 c.1344A>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 761153 c.1347G>C synonymous_variant 0.25 rifampicin
rpoB 761165 c.1359G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 761180 c.1374A>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 761189 c.1383T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 761195 c.1389G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761207 c.1401C>T synonymous_variant 0.23 rifampicin
rpoB 761213 c.1407G>C synonymous_variant 0.27 rifampicin
rpoB 761219 c.1413G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 761249 c.1443A>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 761255 c.1449T>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 761261 c.1455G>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 761306 c.1500C>G synonymous_variant 0.22 rifampicin
rpoB 761510 c.1704T>C synonymous_variant 0.19 rifampicin
rpoB 761537 c.1731C>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 761570 c.1764T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 761573 c.1767C>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 761579 c.1773G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 761588 c.1782C>T synonymous_variant 0.26 rifampicin
rpoB 761606 c.1800C>G synonymous_variant 0.27 rifampicin
rpoB 761612 c.1806G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 761615 c.1809A>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 761636 c.1830G>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 761675 c.1869G>C synonymous_variant 0.23 rifampicin
rpoB 762284 c.2478G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 762293 c.2487T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 762314 c.2508C>T synonymous_variant 0.28 rifampicin
rpoB 762317 c.2511A>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 762329 c.2523G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 762338 c.2532T>C synonymous_variant 0.26 rifampicin
rpoB 762347 c.2541T>C synonymous_variant 0.24 rifampicin
rpoB 762362 p.Glu852Asp missense_variant 0.23 rifampicin
rpoB 762369 c.2563T>C synonymous_variant 0.2 rifampicin
rpoC 762509 c.-861T>G upstream_gene_variant 0.19 rifampicin
rpoB 762510 p.Ala902Pro missense_variant 0.19 rifampicin Uncertain significance
rpoC 762521 c.-849C>T upstream_gene_variant 0.19 rifampicin
rpoC 762533 c.-837T>C upstream_gene_variant 0.21 rifampicin
rpoC 762536 c.-834T>C upstream_gene_variant 0.19 rifampicin
rpoC 762537 c.-833T>C upstream_gene_variant 0.2 rifampicin
rpoC 762551 c.-819C>G upstream_gene_variant 0.16 rifampicin
rpoB 762929 c.3123G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 762989 c.-381G>C upstream_gene_variant 0.27 rifampicin
rpoB 762995 c.3189G>T synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 763013 c.-357C>G upstream_gene_variant 0.29 rifampicin
rpoB 763028 c.3222T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 763034 c.3228C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 763040 c.3234C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 763070 c.3264T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 763085 c.3279C>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 763115 c.3309T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 763136 c.3330C>T synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 763158 c.-212C>T upstream_gene_variant 0.22 rifampicin
rpoB 763166 c.3360A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 763190 c.-180C>T upstream_gene_variant 0.22 rifampicin
rpoC 763202 c.-168A>G upstream_gene_variant 0.22 rifampicin
rpoC 763205 c.-165G>C upstream_gene_variant 0.17 rifampicin
rpoC 763206 c.-164_-162delAGTinsTCG upstream_gene_variant 0.19 rifampicin
rpoB 763214 c.3408T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 763226 c.-144A>G upstream_gene_variant 0.23 rifampicin
rpoB 763227 c.3421C>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 763238 c.3432T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 763402 c.33C>G synonymous_variant 0.16 rifampicin
rpoC 763411 c.42T>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 763414 c.45T>C synonymous_variant 0.24 rifampicin
rpoC 763441 c.72C>T synonymous_variant 0.31 rifampicin
rpoC 763444 c.75T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 763456 c.87A>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 763486 c.117T>G synonymous_variant 0.35 rifampicin
rpoC 763528 c.159G>A synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 763573 c.204G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 763702 c.333C>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 763717 c.348T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 763723 c.354G>C synonymous_variant 0.17 rifampicin
rpoC 763732 c.363C>G synonymous_variant 0.2 rifampicin
rpoC 763741 c.372C>T synonymous_variant 0.18 rifampicin
rpoC 763744 c.375G>C synonymous_variant 0.2 rifampicin
rpoC 763835 p.Ala156Met missense_variant 0.21 rifampicin
rpoC 763853 p.Val162Ile missense_variant 0.21 rifampicin
rpoC 763858 c.489A>G synonymous_variant 0.21 rifampicin
rpoC 764131 c.762T>C synonymous_variant 0.22 rifampicin
rpoC 764140 c.771C>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764203 c.834G>C synonymous_variant 0.22 rifampicin
rpoC 764206 c.837T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 764215 c.846A>G synonymous_variant 0.3 rifampicin
rpoC 764236 c.867G>A synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 764248 c.879C>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 764257 c.888G>C synonymous_variant 0.38 rifampicin
rpoC 764266 c.897T>C synonymous_variant 0.41 rifampicin
rpoC 764611 c.1242G>T synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>C synonymous_variant 0.3 rifampicin
rpoC 764651 c.1282_1284delTCGinsAGC synonymous_variant 0.31 rifampicin
rpoC 764752 c.1383G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 764764 c.1395T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 764809 c.1440C>T synonymous_variant 0.26 rifampicin Not assoc w R
rpoC 764815 c.1446A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 764827 c.1458G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 764858 c.1489T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 764872 c.1503A>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764888 c.1519T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 764911 c.1542A>G synonymous_variant 0.3 rifampicin
rpoC 764932 c.1563C>A synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764935 c.1566T>C synonymous_variant 0.32 rifampicin
rpoC 764948 c.1579T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 764968 c.1599T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 765421 c.2052C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 765613 p.His748Gln missense_variant 0.21 rifampicin
rpoC 765700 c.2331T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 765734 c.2365T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 765772 c.2403C>G synonymous_variant 0.26 rifampicin
rpoC 765784 c.2415C>G synonymous_variant 0.28 rifampicin
rpoC 765826 c.2457T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 765835 c.2466C>T synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 765850 c.2481G>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 765883 c.2514C>G synonymous_variant 0.25 rifampicin
rpoC 765886 c.2517C>G synonymous_variant 0.25 rifampicin
rpoC 765892 c.2523T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 765937 c.2568T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 765967 c.2598C>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 765982 c.2613C>G synonymous_variant 0.23 rifampicin
rpoC 765994 c.2625A>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 766010 c.2641_2642delTCinsAG synonymous_variant 0.18 rifampicin
rpoC 766027 c.2658G>C synonymous_variant 0.17 rifampicin
rpoC 766082 p.Ala905Gln missense_variant 0.21 rifampicin
rpoC 766096 c.2727G>C synonymous_variant 0.23 rifampicin
rpoC 766447 c.3078T>C synonymous_variant 0.22 rifampicin
rpoC 766462 c.3093G>C synonymous_variant 0.22 rifampicin
rpoC 766774 c.3405T>C synonymous_variant 0.19 rifampicin
rpoC 766804 c.3435A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 766861 c.3492G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 766885 c.3516G>A synonymous_variant 0.19 rifampicin
rpoC 766900 c.3531T>C synonymous_variant 0.18 rifampicin
rpoC 766972 c.3603G>C synonymous_variant 0.19 rifampicin
rpoC 766987 c.3618G>C synonymous_variant 0.16 rifampicin
rpoC 767059 c.3690T>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 767062 c.3693C>A synonymous_variant 0.21 rifampicin
rpoC 767098 c.3729T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 767119 c.3750A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 767180 p.Ala1271Gln missense_variant 0.19 rifampicin
rpoC 767191 c.3822C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 767206 c.3837C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 767212 c.3843G>C synonymous_variant 0.16 rifampicin
rpoC 767221 c.3852C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 767230 c.3861G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 767233 c.3864T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
mmpL5 775639 p.Ile948Val missense_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781595 c.36T>C synonymous_variant 0.15 streptomycin
rpsL 781608 p.Ser17Ala missense_variant 0.16 streptomycin
rpsL 781628 c.69T>C synonymous_variant 0.24 streptomycin Not assoc w R - Interim
rpsL 781631 c.72G>C synonymous_variant 0.25 streptomycin
rpsL 781649 c.90T>C synonymous_variant 0.24 streptomycin
rpsL 781655 c.96T>C synonymous_variant 0.24 streptomycin
rpsL 781700 c.141G>C synonymous_variant 0.21 streptomycin
rpsL 781703 c.144G>T synonymous_variant 0.2 streptomycin
rpsL 781715 c.156T>C synonymous_variant 0.18 streptomycin
rpsL 781728 c.169T>C synonymous_variant 0.2 streptomycin
rpsL 781736 c.177T>C synonymous_variant 0.19 streptomycin
rpsL 781742 c.183C>T synonymous_variant 0.21 streptomycin
rpsL 781748 c.189C>G synonymous_variant 0.23 streptomycin
rpsL 781754 c.195G>C synonymous_variant 0.22 streptomycin
rpsL 781760 c.201T>C synonymous_variant 0.25 streptomycin
rpsL 781772 c.213C>A synonymous_variant 0.28 streptomycin
rpsL 781808 c.249C>T synonymous_variant 0.21 streptomycin
rpsL 781811 c.252C>T synonymous_variant 0.22 streptomycin
rpsL 781832 c.273T>C synonymous_variant 0.21 streptomycin
rpsL 781838 c.279G>C synonymous_variant 0.21 streptomycin
rpsL 781841 c.282C>G synonymous_variant 0.19 streptomycin
rpsL 781865 c.306G>C synonymous_variant 0.17 streptomycin
rpsL 781868 c.309T>C synonymous_variant 0.16 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.16 streptomycin
rpsL 781877 c.318T>C synonymous_variant 0.19 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.21 streptomycin
rpsL 781898 c.339A>T synonymous_variant 0.2 streptomycin
rpsL 781916 c.357T>C synonymous_variant 0.18 streptomycin
rpsL 781929 p.Gly124Ser missense_variant 0.16 streptomycin Uncertain significance
rplC 800612 c.-197A>G upstream_gene_variant 0.26 linezolid
rplC 800618 c.-191T>C upstream_gene_variant 0.26 linezolid
rplC 800627 c.-182C>T upstream_gene_variant 0.27 linezolid
rplC 800648 c.-161A>T upstream_gene_variant 0.33 linezolid
rplC 800654 c.-155T>C upstream_gene_variant 0.3 linezolid
rplC 800693 c.-116A>G upstream_gene_variant 0.31 linezolid
rplC 800703 c.-106T>C upstream_gene_variant 0.28 linezolid
rplC 800715 c.-94A>C upstream_gene_variant 0.27 linezolid
rplC 800720 c.-89T>C upstream_gene_variant 0.27 linezolid
rplC 800723 c.-86C>G upstream_gene_variant 0.25 linezolid
rplC 800747 c.-62C>G upstream_gene_variant 0.22 linezolid
rplC 800771 c.-38C>T upstream_gene_variant 0.2 linezolid
rplC 801195 c.387G>C synonymous_variant 0.19 linezolid
rplC 801207 c.399C>T synonymous_variant 0.28 linezolid
rplC 801246 c.438C>T synonymous_variant 0.28 linezolid
rplC 801249 c.441T>C synonymous_variant 0.28 linezolid
rplC 801255 c.447C>T synonymous_variant 0.26 linezolid
rplC 801264 c.456C>T synonymous_variant 0.21 linezolid
rplC 801267 c.459A>T synonymous_variant 0.21 linezolid
rplC 801270 c.462T>C synonymous_variant 0.18 linezolid
rplC 801276 c.468G>C synonymous_variant 0.18 linezolid
rplC 801279 c.471G>A synonymous_variant 0.18 linezolid
rplC 801282 c.474G>C synonymous_variant 0.18 linezolid
rplC 801285 c.477G>C synonymous_variant 0.18 linezolid
rplC 801367 p.Ala187Thr missense_variant 0.16 linezolid
rplC 801442 p.Ile212Val missense_variant 0.15 linezolid
fbiC 1304535 c.1605G>A synonymous_variant 0.17 pretomanid
delamanid
clofazimine
fbiC 1304544 c.1614T>C synonymous_variant 0.17 pretomanid
delamanid
clofazimine
fbiC 1304545 p.Val539Thr missense_variant 0.16 pretomanid
delamanid
clofazimine
fbiC 1304553 c.1623C>T synonymous_variant 0.18 pretomanid
delamanid
clofazimine
fbiC 1304559 p.Glu543Asp missense_variant 0.18 pretomanid
delamanid
clofazimine
fbiC 1304565 c.1635C>G synonymous_variant 0.16 pretomanid
delamanid
clofazimine
fbiC 1304568 c.1638T>C synonymous_variant 0.17 pretomanid
delamanid
clofazimine
fbiC 1304580 c.1650T>C synonymous_variant 0.15 pretomanid
delamanid
clofazimine
fbiC 1304784 c.1854T>C synonymous_variant 0.16 pretomanid
delamanid
clofazimine
fbiC 1304787 c.1857T>G synonymous_variant 0.16 pretomanid
delamanid
clofazimine
fbiC 1304808 c.1878C>G synonymous_variant 0.18 pretomanid
delamanid
clofazimine
fbiC 1304811 c.1881C>G synonymous_variant 0.22 pretomanid
delamanid
clofazimine
fbiC 1304817 c.1887T>C synonymous_variant 0.24 pretomanid
delamanid
clofazimine
fbiC 1304829 c.1899T>C synonymous_variant 0.39 pretomanid
delamanid
clofazimine
fbiC 1304832 c.1902C>T synonymous_variant 0.41 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R - Interim
fbiC 1304856 c.1926C>G synonymous_variant 0.52 pretomanid
delamanid
clofazimine
fbiC 1304869 c.1939C>T synonymous_variant 0.3 pretomanid
delamanid
clofazimine
fbiC 1304875 p.Ile649Val missense_variant 0.29 pretomanid
delamanid
clofazimine
fbiC 1304883 p.Glu651Asp missense_variant 0.27 pretomanid
delamanid
clofazimine
fbiC 1304891 p.Ile654Thr missense_variant 0.23 pretomanid
delamanid
clofazimine
fbiC 1304893 p.Gly655Ser missense_variant 0.23 pretomanid
delamanid
clofazimine
fbiC 1304916 c.1986T>C synonymous_variant 0.22 pretomanid
delamanid
clofazimine
fbiC 1305372 c.2442G>A synonymous_variant 0.17 pretomanid
delamanid
clofazimine Not assoc w R - Interim
fbiC 1305384 c.2454G>C synonymous_variant 0.16 pretomanid
delamanid
clofazimine
fbiC 1305396 c.2466C>G synonymous_variant 0.17 pretomanid
delamanid
clofazimine
fbiC 1305405 c.2475A>G synonymous_variant 0.18 pretomanid
delamanid
clofazimine Not assoc w R - Interim
atpE 1460831 c.-214T>C upstream_gene_variant 0.2 bedaquiline
atpE 1460840 c.-205A>G upstream_gene_variant 0.25 bedaquiline
atpE 1460852 c.-193C>G upstream_gene_variant 0.21 bedaquiline
atpE 1460855 c.-190T>C upstream_gene_variant 0.2 bedaquiline
atpE 1460858 c.-187C>G upstream_gene_variant 0.2 bedaquiline
atpE 1460861 c.-184C>G upstream_gene_variant 0.2 bedaquiline
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472150 n.305T>A non_coding_transcript_exon_variant 0.73 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472172 n.327T>C non_coding_transcript_exon_variant 0.52 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472251 n.406G>A non_coding_transcript_exon_variant 0.92 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472530 n.685G>A non_coding_transcript_exon_variant 0.62 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472537 n.692C>T non_coding_transcript_exon_variant 0.44 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472544 n.699C>A non_coding_transcript_exon_variant 0.48 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472545 n.700A>T non_coding_transcript_exon_variant 0.46 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472566 n.721G>A non_coding_transcript_exon_variant 0.41 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472571 n.726G>C non_coding_transcript_exon_variant 0.48 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472579 n.734G>T non_coding_transcript_exon_variant 0.35 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472581 n.736A>T non_coding_transcript_exon_variant 0.71 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472584 n.739A>T non_coding_transcript_exon_variant 0.36 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472598 n.753A>C non_coding_transcript_exon_variant 0.46 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472599 n.754G>T non_coding_transcript_exon_variant 0.46 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472742 n.897C>T non_coding_transcript_exon_variant 0.6 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472744 n.899A>G non_coding_transcript_exon_variant 0.64 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472781 n.936C>T non_coding_transcript_exon_variant 0.59 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472790 n.945T>C non_coding_transcript_exon_variant 0.31 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472793 n.948A>T non_coding_transcript_exon_variant 0.56 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472803 n.958T>A non_coding_transcript_exon_variant 0.62 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472895 n.1050C>T non_coding_transcript_exon_variant 0.75 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472954 n.1109T>C non_coding_transcript_exon_variant 0.35 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472956 n.1111T>C non_coding_transcript_exon_variant 0.68 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472957 n.1112C>T non_coding_transcript_exon_variant 0.73 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472973 n.1128A>G non_coding_transcript_exon_variant 0.43 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472987 n.1142G>A non_coding_transcript_exon_variant 0.58 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472989 n.1144G>A non_coding_transcript_exon_variant 0.58 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472990 n.1145A>G non_coding_transcript_exon_variant 0.81 kanamycin Not assoc w R
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1473035 n.1190G>A non_coding_transcript_exon_variant 0.9 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1473055 n.1210C>T non_coding_transcript_exon_variant 0.88 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473056 n.1211A>T non_coding_transcript_exon_variant 0.88 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1473066 n.1221A>G non_coding_transcript_exon_variant 0.89 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473088 n.1243A>G non_coding_transcript_exon_variant 0.86 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473093 n.1248C>T non_coding_transcript_exon_variant 0.62 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473121 n.1276T>C non_coding_transcript_exon_variant 0.85 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.62 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473148 n.1303G>T non_coding_transcript_exon_variant 0.27 kanamycin
capreomycin
streptomycin
amikacin
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.7 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrl 1475883 n.2226A>T non_coding_transcript_exon_variant 0.7 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475900 n.2243A>G non_coding_transcript_exon_variant 0.64 capreomycin Uncertain significance
linezolid
rrl 1475902 n.2245T>C non_coding_transcript_exon_variant 0.6 capreomycin Uncertain significance
linezolid
rrl 1475906 n.2249C>T non_coding_transcript_exon_variant 0.6 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476359 n.2702C>G non_coding_transcript_exon_variant 0.62 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476369 n.2712C>T non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476381 n.2724G>C non_coding_transcript_exon_variant 0.71 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476428 n.2771C>T non_coding_transcript_exon_variant 0.74 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476429 n.2772A>T non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid
rrl 1476466 n.2809C>T non_coding_transcript_exon_variant 0.64 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.73 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476585 n.2928A>G non_coding_transcript_exon_variant 0.64 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476608 n.2951C>G non_coding_transcript_exon_variant 0.55 capreomycin Uncertain significance
linezolid Uncertain significance
inhA 1674549 c.348G>C synonymous_variant 0.16 isoniazid
ethionamide
inhA 1674555 c.354G>A synonymous_variant 0.16 isoniazid Not assoc w R - Interim
ethionamide Not assoc w R - Interim
inhA 1674561 c.360C>T synonymous_variant 0.22 isoniazid
ethionamide
inhA 1674582 c.381T>C synonymous_variant 0.28 isoniazid
ethionamide
inhA 1674585 c.384T>C synonymous_variant 0.29 isoniazid
ethionamide
inhA 1674589 p.Met130Leu missense_variant 0.32 isoniazid
ethionamide
inhA 1674601 p.Leu134Ala missense_variant 0.24 isoniazid
ethionamide
inhA 1674624 c.423A>C synonymous_variant 0.17 isoniazid
ethionamide
inhA 1674636 c.435C>G synonymous_variant 0.22 isoniazid
ethionamide
inhA 1674660 c.459G>C synonymous_variant 0.28 isoniazid
ethionamide
inhA 1674703 c.502T>C synonymous_variant 0.23 isoniazid
ethionamide
inhA 1674708 c.507G>A synonymous_variant 0.23 isoniazid
ethionamide
inhA 1674718 c.517A>C synonymous_variant 0.21 isoniazid
ethionamide
inhA 1674729 c.528G>C synonymous_variant 0.27 isoniazid
ethionamide
inhA 1674732 c.531C>T synonymous_variant 0.21 isoniazid
ethionamide
inhA 1674846 p.Ile215Met missense_variant 0.23 isoniazid
ethionamide
inhA 1674864 c.663C>T synonymous_variant 0.2 isoniazid Not assoc w R - Interim
ethionamide Not assoc w R - Interim
inhA 1674870 c.669T>C synonymous_variant 0.21 isoniazid
ethionamide
inhA 1674879 c.678T>C synonymous_variant 0.2 isoniazid
ethionamide
inhA 1674904 p.Ala235Pro missense_variant 0.21 isoniazid
ethionamide
inhA 1674909 c.708G>C synonymous_variant 0.21 isoniazid
ethionamide
rpsA 1833589 c.48A>T synonymous_variant 0.17 pyrazinamide
rpsA 1833595 c.54T>C synonymous_variant 0.21 pyrazinamide
rpsA 1833661 c.120A>G synonymous_variant 0.17 pyrazinamide
rpsA 1833667 c.126C>G synonymous_variant 0.17 pyrazinamide
rpsA 1833721 c.180A>G synonymous_variant 0.19 pyrazinamide
rpsA 1833724 c.183C>G synonymous_variant 0.21 pyrazinamide
rpsA 1833727 c.186G>C synonymous_variant 0.2 pyrazinamide
rpsA 1833742 c.201A>G synonymous_variant 0.2 pyrazinamide
rpsA 1833745 c.204G>C synonymous_variant 0.21 pyrazinamide
rpsA 1833748 c.207C>G synonymous_variant 0.2 pyrazinamide
rpsA 1833787 c.246C>G synonymous_variant 0.28 pyrazinamide
rpsA 1833790 c.249T>C synonymous_variant 0.27 pyrazinamide
rpsA 1833802 c.261A>G synonymous_variant 0.29 pyrazinamide
rpsA 1833811 c.270G>T synonymous_variant 0.36 pyrazinamide
rpsA 1833838 c.297G>C synonymous_variant 0.38 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.38 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.41 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.44 pyrazinamide
rpsA 1833874 c.333T>C synonymous_variant 0.34 pyrazinamide
rpsA 1833886 c.345C>G synonymous_variant 0.32 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.23 pyrazinamide
rpsA 1833940 c.399C>G synonymous_variant 0.22 pyrazinamide
rpsA 1833971 c.430C>T synonymous_variant 0.31 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.28 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.3 pyrazinamide
rpsA 1834021 c.480C>T synonymous_variant 0.29 pyrazinamide
rpsA 1834030 c.489C>G synonymous_variant 0.26 pyrazinamide
rpsA 1834231 c.690T>C synonymous_variant 0.15 pyrazinamide
rpsA 1834234 c.693G>C synonymous_variant 0.15 pyrazinamide
rpsA 1834249 c.708T>C synonymous_variant 0.18 pyrazinamide
rpsA 1834261 c.720A>G synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
rpsA 1834262 p.Ser241Thr missense_variant 0.16 pyrazinamide
rpsA 1834303 c.762T>C synonymous_variant 0.21 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.25 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 0.37 pyrazinamide Not assoc w R - Interim
rpsA 1834366 c.825A>G synonymous_variant 0.36 pyrazinamide Not assoc w R - Interim
rpsA 1834396 c.855G>C synonymous_variant 0.34 pyrazinamide
rpsA 1834411 c.870T>C synonymous_variant 0.35 pyrazinamide
rpsA 1834417 c.876G>C synonymous_variant 0.32 pyrazinamide
rpsA 1834423 c.882G>C synonymous_variant 0.33 pyrazinamide
rpsA 1834435 c.894G>C synonymous_variant 0.29 pyrazinamide
rpsA 1834451 c.910T>C synonymous_variant 0.26 pyrazinamide
rpsA 1834465 c.924T>C synonymous_variant 0.23 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.25 pyrazinamide
rpsA 1834489 c.948T>C synonymous_variant 0.31 pyrazinamide
rpsA 1834513 c.972C>G synonymous_variant 0.41 pyrazinamide
rpsA 1834528 c.987T>C synonymous_variant 0.41 pyrazinamide
rpsA 1834540 c.999G>C synonymous_variant 0.41 pyrazinamide
rpsA 1834546 c.1005T>C synonymous_variant 0.33 pyrazinamide
rpsA 1834555 c.1014T>G synonymous_variant 0.35 pyrazinamide
rpsA 1834609 c.1068T>C synonymous_variant 0.29 pyrazinamide
rpsA 1834618 c.1077G>C synonymous_variant 0.31 pyrazinamide
rpsA 1834633 c.1092A>G synonymous_variant 0.32 pyrazinamide
rpsA 1834639 c.1098T>C synonymous_variant 0.31 pyrazinamide
rpsA 1834654 p.Glu371Asp missense_variant 0.29 pyrazinamide
rpsA 1834753 c.1212T>C synonymous_variant 0.16 pyrazinamide
rpsA 1834765 p.Glu408Asp missense_variant 0.17 pyrazinamide
rpsA 1834775 p.Ala412Thr missense_variant 0.2 pyrazinamide
rpsA 1834780 c.1239A>G synonymous_variant 0.18 pyrazinamide
rpsA 1834789 c.1248T>C synonymous_variant 0.17 pyrazinamide
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
bacA 2064933 c.-205A>G upstream_gene_variant 0.17 kanamycin
capreomycin
streptomycin
amikacin
bacA 2064936 c.-208C>G upstream_gene_variant 0.19 kanamycin
capreomycin
streptomycin
amikacin
bacA 2064942 c.-214G>A upstream_gene_variant 0.2 kanamycin
capreomycin
streptomycin
amikacin
bacA 2064948 c.-220G>C upstream_gene_variant 0.23 kanamycin
capreomycin
streptomycin
amikacin
bacA 2064972 c.-244T>C upstream_gene_variant 0.22 kanamycin
capreomycin
streptomycin
amikacin
bacA 2064978 c.-250G>C upstream_gene_variant 0.22 kanamycin
capreomycin
streptomycin
amikacin
bacA 2064979 c.-251C>T upstream_gene_variant 0.23 kanamycin
capreomycin
streptomycin
amikacin
bacA 2064984 c.-256A>G upstream_gene_variant 0.22 kanamycin
capreomycin
streptomycin
amikacin
bacA 2064993 c.-265T>C upstream_gene_variant 0.26 kanamycin
capreomycin
streptomycin
amikacin
ndh 2101744 p.Asp433Glu missense_variant 0.16 isoniazid
delamanid
ethionamide
ndh 2101756 c.1287G>C synonymous_variant 0.16 isoniazid
delamanid
ethionamide
ndh 2101765 c.1278C>G synonymous_variant 0.18 isoniazid
delamanid
ethionamide
ndh 2101768 c.1275C>A synonymous_variant 0.17 isoniazid
delamanid
ethionamide
ndh 2101771 c.1272T>G synonymous_variant 0.16 isoniazid Not assoc w R - Interim
delamanid
ethionamide
ndh 2101774 c.1269T>C synonymous_variant 0.16 isoniazid
delamanid
ethionamide
ndh 2101777 c.1266C>G synonymous_variant 0.17 isoniazid Not assoc w R - Interim
delamanid
ethionamide Not assoc w R - Interim
ndh 2101783 c.1260T>A synonymous_variant 0.15 isoniazid
delamanid
ethionamide
ndh 2101972 c.1071G>C synonymous_variant 0.18 isoniazid
delamanid
ethionamide
ndh 2101988 p.Ala352Asp missense_variant 0.17 isoniazid
delamanid
ethionamide
ndh 2102014 c.1029C>G synonymous_variant 0.17 isoniazid
delamanid
ethionamide
katG 2155716 c.396T>G synonymous_variant 0.18 isoniazid
katG 2155722 c.390G>C synonymous_variant 0.18 isoniazid
PPE35 2168149 p.Pro822Ser missense_variant 1.0 pyrazinamide Not assoc w R
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
pncA 2289997 c.-756G>C upstream_gene_variant 0.16 pyrazinamide
kasA 2518506 p.Ala131Glu missense_variant 0.18 isoniazid
kasA 2518519 c.405G>C synonymous_variant 0.2 isoniazid
kasA 2518528 c.414C>G synonymous_variant 0.19 isoniazid
kasA 2518540 c.426T>C synonymous_variant 0.25 isoniazid
kasA 2518561 c.447T>C synonymous_variant 0.23 isoniazid
kasA 2518567 c.453G>C synonymous_variant 0.24 isoniazid
kasA 2518570 c.456G>C synonymous_variant 0.25 isoniazid
kasA 2518574 p.Ile154Val missense_variant 0.24 isoniazid
kasA 2518579 c.465T>C synonymous_variant 0.24 isoniazid
kasA 2518588 c.474T>C synonymous_variant 0.24 isoniazid
kasA 2518591 c.477G>C synonymous_variant 0.24 isoniazid
kasA 2518609 p.Met165Ile missense_variant 0.27 isoniazid
kasA 2518768 c.654C>T synonymous_variant 0.17 isoniazid
kasA 2518777 c.663C>T synonymous_variant 0.17 isoniazid
kasA 2518783 c.669T>C synonymous_variant 0.19 isoniazid
kasA 2518789 c.675G>C synonymous_variant 0.18 isoniazid
kasA 2518792 c.678C>A synonymous_variant 0.18 isoniazid
kasA 2518795 c.681C>G synonymous_variant 0.18 isoniazid
kasA 2518825 c.711T>C synonymous_variant 0.21 isoniazid
kasA 2519072 p.Ala320Thr missense_variant 0.14 isoniazid
kasA 2519107 c.993T>C synonymous_variant 0.18 isoniazid
kasA 2519108 p.Asp332Gln missense_variant 0.17 isoniazid
kasA 2519116 c.1002C>G synonymous_variant 0.21 isoniazid
kasA 2519122 c.1008G>C synonymous_variant 0.21 isoniazid
kasA 2519137 c.1023T>G synonymous_variant 0.21 isoniazid
kasA 2519158 c.1044C>T synonymous_variant 0.2 isoniazid
Rv2477c 2782450 c.1593C>A synonymous_variant 0.16 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782453 c.1590C>G synonymous_variant 0.19 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782483 c.1560G>C synonymous_variant 0.19 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782513 c.1530G>C synonymous_variant 0.2 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782522 c.1521G>C synonymous_variant 0.19 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782528 c.1515G>C synonymous_variant 0.22 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782537 c.1506T>G synonymous_variant 0.22 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782540 c.1503T>C synonymous_variant 0.22 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782546 c.1497C>G synonymous_variant 0.17 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782549 c.1494T>C synonymous_variant 0.17 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin
Rv2477c 2782990 c.1053C>G synonymous_variant 0.24 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783002 c.1041T>C synonymous_variant 0.22 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783008 c.1035C>G synonymous_variant 0.23 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783013 c.1030T>C synonymous_variant 0.24 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783015 p.Ser343Thr missense_variant 0.26 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783035 c.1008G>C synonymous_variant 0.26 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783040 p.Ala335Thr missense_variant 0.24 kanamycin Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
rifampicin Uncertain significance
ethambutol Uncertain significance
amikacin Uncertain significance
Rv2477c 2783044 c.999G>C synonymous_variant 0.24 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783048 p.Asp332Gly missense_variant 0.25 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783059 c.984T>C synonymous_variant 0.29 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783068 p.Asp325Glu missense_variant 0.3 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783077 c.966T>C synonymous_variant 0.26 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783101 c.942G>T synonymous_variant 0.28 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783116 c.927T>C synonymous_variant 0.24 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783140 c.903C>G synonymous_variant 0.31 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783146 c.897G>A synonymous_variant 0.34 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
rifampicin
ethambutol
amikacin Not assoc w R - Interim
Rv2477c 2783149 c.894G>C synonymous_variant 0.32 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
rifampicin Not assoc w R - Interim
ethambutol
amikacin Not assoc w R - Interim
Rv2477c 2783254 c.789A>G synonymous_variant 0.26 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783263 c.780G>C synonymous_variant 0.25 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783275 c.768C>G synonymous_variant 0.22 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783278 c.765A>G synonymous_variant 0.2 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783311 c.732T>C synonymous_variant 0.19 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783314 c.729C>G synonymous_variant 0.19 kanamycin
levofloxacin
moxifloxacin
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin
Rv2477c 2783317 c.726G>C synonymous_variant 0.19 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783332 c.711T>C synonymous_variant 0.2 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783335 c.708C>G synonymous_variant 0.19 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783344 c.699C>G synonymous_variant 0.16 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783751 p.Ile98Val missense_variant 0.19 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783758 p.Asp95Glu missense_variant 0.17 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783761 c.282G>C synonymous_variant 0.17 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783766 p.Met93Leu missense_variant 0.17 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783797 p.Asp82Glu missense_variant 0.16 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783822 p.Gln74Leu missense_variant 0.14 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783860 c.183T>C synonymous_variant 0.16 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783863 c.180C>T synonymous_variant 0.18 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783887 c.156C>G synonymous_variant 0.16 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2784452 c.-410C>T upstream_gene_variant 0.23 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2784454 c.-412G>A upstream_gene_variant 0.23 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2784456 c.-414A>C upstream_gene_variant 0.25 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2784472 c.-430C>A upstream_gene_variant 0.25 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2784477 c.-435T>C upstream_gene_variant 0.24 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2680 2995848 c.-257G>A upstream_gene_variant 1.0 capreomycin
Rv2752c 3065241 c.951A>G synonymous_variant 0.19 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066339 c.-148G>C upstream_gene_variant 0.16 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066531 c.-340C>G upstream_gene_variant 0.16 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066549 c.-358T>C upstream_gene_variant 0.21 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066561 c.-370A>C upstream_gene_variant 0.2 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066567 c.-376C>G upstream_gene_variant 0.22 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066573 c.-382G>C upstream_gene_variant 0.24 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
thyX 3067325 c.621A>G synonymous_variant 0.17 para-aminosalicylic_acid
thyX 3067349 c.597G>C synonymous_variant 0.2 para-aminosalicylic_acid
thyX 3067355 c.591A>C synonymous_variant 0.21 para-aminosalicylic_acid
thyX 3067367 c.579G>C synonymous_variant 0.21 para-aminosalicylic_acid
thyX 3067373 c.573C>G synonymous_variant 0.21 para-aminosalicylic_acid
thyX 3067376 c.570G>A synonymous_variant 0.22 para-aminosalicylic_acid
thyX 3067391 c.555G>C synonymous_variant 0.28 para-aminosalicylic_acid
thyX 3067394 c.552G>C synonymous_variant 0.27 para-aminosalicylic_acid
thyX 3067439 c.507A>G synonymous_variant 0.33 para-aminosalicylic_acid
thyX 3067445 c.501C>G synonymous_variant 0.33 para-aminosalicylic_acid
thyX 3067457 c.489C>G synonymous_variant 0.3 para-aminosalicylic_acid
thyX 3067465 p.Ile161Val missense_variant 0.25 para-aminosalicylic_acid
thyX 3067475 c.471A>G synonymous_variant 0.27 para-aminosalicylic_acid
thyX 3067490 c.456C>G synonymous_variant 0.26 para-aminosalicylic_acid
thyX 3067493 c.453A>G synonymous_variant 0.27 para-aminosalicylic_acid
thyX 3067515 p.Ser144Thr missense_variant 0.29 para-aminosalicylic_acid
thyX 3067530 p.Ala139Ser missense_variant 0.16 para-aminosalicylic_acid
thyX 3067545 p.Glu134Ala missense_variant 0.16 para-aminosalicylic_acid
thyX 3067565 p.Asp127Glu missense_variant 0.16 para-aminosalicylic_acid
thyX 3067583 c.363C>G synonymous_variant 0.2 para-aminosalicylic_acid
thyX 3067602 p.Arg115Gln missense_variant 0.15 para-aminosalicylic_acid
thyX 3067611 p.Lys112Thr missense_variant 0.17 para-aminosalicylic_acid
thyX 3067619 c.327A>C synonymous_variant 0.19 para-aminosalicylic_acid
thyX 3067631 c.315C>G synonymous_variant 0.19 para-aminosalicylic_acid
thyX 3067634 c.312C>G synonymous_variant 0.18 para-aminosalicylic_acid
thyX 3067652 c.294T>C synonymous_variant 0.21 para-aminosalicylic_acid
thyX 3067661 c.285C>G synonymous_variant 0.21 para-aminosalicylic_acid
thyX 3067685 c.261A>C synonymous_variant 0.22 para-aminosalicylic_acid
thyX 3067691 p.Ile85Leu missense_variant 0.2 para-aminosalicylic_acid
thyX 3067694 c.252G>C synonymous_variant 0.19 para-aminosalicylic_acid
thyX 3067718 c.228C>G synonymous_variant 0.19 para-aminosalicylic_acid
thyX 3067721 c.225T>C synonymous_variant 0.16 para-aminosalicylic_acid
thyX 3067736 c.210C>T synonymous_variant 0.15 para-aminosalicylic_acid
thyX 3067781 c.165C>A synonymous_variant 0.14 para-aminosalicylic_acid
thyX 3067793 c.153T>C synonymous_variant 0.16 para-aminosalicylic_acid
thyX 3067799 c.147G>A synonymous_variant 0.15 para-aminosalicylic_acid
thyX 3067850 c.96A>C synonymous_variant 0.18 para-aminosalicylic_acid
thyX 3067869 p.Thr26Ser missense_variant 0.16 para-aminosalicylic_acid
thyX 3067874 c.72C>G synonymous_variant 0.15 para-aminosalicylic_acid
thyA 3073836 c.636C>T synonymous_variant 0.22 para-aminosalicylic_acid
thyA 3073839 c.633T>C synonymous_variant 0.27 para-aminosalicylic_acid
thyA 3073860 c.612C>G synonymous_variant 0.36 para-aminosalicylic_acid
thyA 3073863 c.609T>C synonymous_variant 0.33 para-aminosalicylic_acid
thyA 3073866 c.606C>G synonymous_variant 0.33 para-aminosalicylic_acid
thyA 3073872 p.Ile200Val missense_variant 0.33 para-aminosalicylic_acid
thyA 3073892 c.580T>C synonymous_variant 0.4 para-aminosalicylic_acid
thyA 3073898 p.Ala192Ser missense_variant 0.38 para-aminosalicylic_acid
thyA 3073917 c.555C>G synonymous_variant 0.36 para-aminosalicylic_acid
thyA 3073920 c.552C>G synonymous_variant 0.37 para-aminosalicylic_acid
thyA 3073925 c.547T>C synonymous_variant 0.38 para-aminosalicylic_acid
thyA 3073929 c.543T>C synonymous_variant 0.37 para-aminosalicylic_acid
thyA 3073953 c.519T>C synonymous_variant 0.29 para-aminosalicylic_acid
thyA 3073956 c.516G>C synonymous_variant 0.27 para-aminosalicylic_acid
thyA 3073959 c.513T>C synonymous_variant 0.26 para-aminosalicylic_acid
thyA 3073977 c.495A>G synonymous_variant 0.26 para-aminosalicylic_acid
Rv3083 3448507 c.5_*1408del frameshift_variant&stop_lost&splice_region_variant 1.0 ethionamide Uncertain significance
Rv3236c 3613636 c.-520A>G upstream_gene_variant 1.0 pyrazinamide Not assoc w R
lpqB 3624050 c.861C>G synonymous_variant 0.18 rifampicin
bedaquiline
lpqB 3624077 c.834G>A synonymous_variant 0.22 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3624082 c.829A>C synonymous_variant 0.22 rifampicin
bedaquiline
lpqB 3624086 c.825C>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
bedaquiline Not assoc w R - Interim
lpqB 3624092 c.817_819delAGGinsCGC synonymous_variant 0.21 rifampicin
bedaquiline
lpqB 3624100 c.811T>C synonymous_variant 0.2 rifampicin
bedaquiline
lpqB 3624101 c.810C>G synonymous_variant 0.19 rifampicin
bedaquiline
lpqB 3624107 c.804C>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3624116 c.795A>G synonymous_variant 0.2 rifampicin
bedaquiline
lpqB 3624119 c.792C>G synonymous_variant 0.21 rifampicin
bedaquiline
lpqB 3624124 p.Leu263Val missense_variant 0.19 rifampicin
bedaquiline
lpqB 3624125 c.786A>G synonymous_variant 0.19 rifampicin
bedaquiline
lpqB 3624143 c.768T>C synonymous_variant 0.22 rifampicin
bedaquiline
lpqB 3624701 c.210T>C synonymous_variant 0.16 rifampicin
bedaquiline
lpqB 3624704 c.207G>C synonymous_variant 0.16 rifampicin
bedaquiline
lpqB 3624707 c.204G>C synonymous_variant 0.17 rifampicin
bedaquiline
lpqB 3624722 c.189C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
bedaquiline Not assoc w R - Interim
mtrB 3625189 c.1425A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3625195 c.-285A>G upstream_gene_variant 0.2 rifampicin
bedaquiline
lpqB 3625201 c.-291T>C upstream_gene_variant 0.22 rifampicin
bedaquiline
mtrB 3625206 p.Ser470Ala missense_variant 0.2 rifampicin
bedaquiline
mtrB 3625222 c.1392T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3625225 c.-315G>C upstream_gene_variant 0.25 rifampicin
bedaquiline
lpqB 3625240 c.-330T>C upstream_gene_variant 0.23 rifampicin
bedaquiline
lpqB 3625243 c.-333T>G upstream_gene_variant 0.24 rifampicin
bedaquiline
lpqB 3625543 c.-633G>C upstream_gene_variant 0.15 rifampicin
bedaquiline
lpqB 3625549 c.-639G>A upstream_gene_variant 0.2 rifampicin
bedaquiline
mtrB 3625569 c.1045T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625572 p.Thr348Ser missense_variant 0.21 rifampicin
bedaquiline
lpqB 3625579 c.-669A>G upstream_gene_variant 0.22 rifampicin
bedaquiline
lpqB 3625594 c.-684T>C upstream_gene_variant 0.24 rifampicin
bedaquiline
lpqB 3625602 c.-692T>C upstream_gene_variant 0.24 rifampicin
bedaquiline
lpqB 3625612 c.-702G>C upstream_gene_variant 0.23 rifampicin
bedaquiline
mtrB 3625616 p.Arg333Ala missense_variant 0.24 rifampicin
bedaquiline
lpqB 3625624 c.-714C>G upstream_gene_variant 0.25 rifampicin
bedaquiline
mtrB 3625636 c.978C>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625656 c.958T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
bedaquiline Not assoc w R - Interim
lpqB 3625663 c.-753G>C upstream_gene_variant 0.21 rifampicin
bedaquiline
lpqB 3625669 c.-759G>C upstream_gene_variant 0.19 rifampicin
bedaquiline
lpqB 3625696 c.-786A>G upstream_gene_variant 0.17 rifampicin
bedaquiline
mtrB 3625705 c.909C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3625714 c.-804C>T upstream_gene_variant 0.21 rifampicin
bedaquiline
mtrB 3625720 c.894G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625729 c.885A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3625735 c.-825C>T upstream_gene_variant 0.22 rifampicin
bedaquiline
lpqB 3625749 c.-839C>T upstream_gene_variant 0.23 rifampicin
bedaquiline
mtrB 3625750 c.864G>A synonymous_variant 0.24 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625755 p.Ala287Thr missense_variant 0.23 rifampicin Uncertain significance
bedaquiline
mtrB 3625765 c.849C>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625774 c.840G>A synonymous_variant 0.29 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625797 p.Val273Met missense_variant 0.27 rifampicin Uncertain significance
bedaquiline Uncertain significance
mtrB 3625806 c.808A>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625807 c.807C>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625837 c.777C>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3625849 c.-939T>C upstream_gene_variant 0.18 rifampicin
bedaquiline
mtrB 3625852 c.762A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3625864 c.-954T>G upstream_gene_variant 0.21 rifampicin
bedaquiline
mtrB 3625876 c.738G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3625900 c.-990G>C upstream_gene_variant 0.2 rifampicin
bedaquiline
lpqB 3625903 c.-993G>C upstream_gene_variant 0.21 rifampicin
bedaquiline
lpqB 3625909 c.-999T>C upstream_gene_variant 0.21 rifampicin
bedaquiline
mtrB 3626729 c.-116G>A upstream_gene_variant 0.16 rifampicin
bedaquiline
mtrB 3626732 c.-119A>G upstream_gene_variant 0.16 rifampicin
bedaquiline
mtrA 3626759 c.591T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626774 c.-163_-161delAGGinsCGC upstream_gene_variant 0.19 rifampicin
bedaquiline
mtrB 3626783 c.-170C>G upstream_gene_variant 0.17 rifampicin
bedaquiline
mtrA 3626786 c.564A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626798 c.-185T>C upstream_gene_variant 0.18 rifampicin
bedaquiline
mtrA 3626804 c.546A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626840 c.-227C>G upstream_gene_variant 0.17 rifampicin
bedaquiline
mtrA 3626846 c.504G>A synonymous_variant 0.15 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626858 c.-245A>G upstream_gene_variant 0.16 rifampicin
bedaquiline
mtrB 3626861 c.-248C>G upstream_gene_variant 0.16 rifampicin
bedaquiline
mtrB 3626866 c.-253T>C upstream_gene_variant 0.17 rifampicin
bedaquiline
mtrB 3626876 c.-263A>G upstream_gene_variant 0.21 rifampicin
bedaquiline
mtrB 3626885 c.-272A>C upstream_gene_variant 0.21 rifampicin
bedaquiline
mtrB 3626890 c.-277T>C upstream_gene_variant 0.21 rifampicin
bedaquiline
mtrB 3626903 c.-290T>C upstream_gene_variant 0.18 rifampicin
bedaquiline
mtrB 3626912 c.-299T>G upstream_gene_variant 0.2 rifampicin
bedaquiline
mtrB 3626930 c.-317A>G upstream_gene_variant 0.15 rifampicin
bedaquiline
mtrA 3627071 c.279G>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
bedaquiline
mtrA 3627080 c.270T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627083 c.-470G>C upstream_gene_variant 0.16 rifampicin
bedaquiline
mtrA 3627098 c.252A>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627104 c.-491C>G upstream_gene_variant 0.17 rifampicin
bedaquiline
mtrA 3627119 c.231T>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627122 c.-509T>C upstream_gene_variant 0.18 rifampicin
bedaquiline
mtrB 3627181 c.-568T>C upstream_gene_variant 0.17 rifampicin
bedaquiline
mtrB 3627182 c.-569T>C upstream_gene_variant 0.17 rifampicin
bedaquiline
mtrA 3627188 c.162A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627209 c.-596G>A upstream_gene_variant 0.26 rifampicin
bedaquiline
mtrA 3627221 c.129C>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
bedaquiline
mtrA 3627227 c.123T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627233 c.-620T>C upstream_gene_variant 0.23 rifampicin
bedaquiline
mtrB 3627236 c.-623T>C upstream_gene_variant 0.24 rifampicin
bedaquiline
mtrA 3627242 c.108C>T synonymous_variant 0.29 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627254 c.-641C>T upstream_gene_variant 0.29 rifampicin
bedaquiline
mtrB 3627263 c.-650C>T upstream_gene_variant 0.31 rifampicin
bedaquiline
mtrB 3627266 c.-653A>G upstream_gene_variant 0.31 rifampicin
bedaquiline
mtrB 3627272 c.-659G>T upstream_gene_variant 0.3 rifampicin
bedaquiline
mtrB 3627275 c.-662G>T upstream_gene_variant 0.3 rifampicin
bedaquiline
mtrB 3627296 c.-683T>C upstream_gene_variant 0.22 rifampicin
bedaquiline
mtrB 3627299 c.-688_-686delTTGinsCTA upstream_gene_variant 0.22 rifampicin
bedaquiline
mtrB 3627314 c.-701C>T upstream_gene_variant 0.2 rifampicin
bedaquiline
mtrB 3627317 c.-704T>C upstream_gene_variant 0.19 rifampicin
bedaquiline
rpoA 3877553 p.Glu319Gln missense_variant 0.21 rifampicin
rpoA 3877571 p.Pro313Ala missense_variant 0.2 rifampicin
rpoA 3877587 c.921A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoA 3877613 p.Ile299Val missense_variant 0.19 rifampicin
rpoA 3877656 c.852T>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3877668 c.840A>G synonymous_variant 0.2 rifampicin
rpoA 3877679 p.Ala277Ser missense_variant 0.16 rifampicin
rpoA 3877686 c.822A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3877692 c.816G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3877776 c.732T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoA 3877782 c.726T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoA 3877791 c.717C>G synonymous_variant 0.29 rifampicin
rpoA 3877818 c.690A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoA 3877839 c.669G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3877848 c.660C>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoA 3877857 c.651G>A synonymous_variant 0.19 rifampicin
rpoA 3877866 c.642G>C synonymous_variant 0.22 rifampicin
rpoA 3877875 c.633T>G synonymous_variant 0.24 rifampicin
rpoA 3877878 c.630G>C synonymous_variant 0.23 rifampicin
rpoA 3877890 c.618C>T synonymous_variant 0.25 rifampicin
rpoA 3877896 c.612G>C synonymous_variant 0.26 rifampicin
rpoA 3877900 p.Ser203Asn missense_variant 0.23 rifampicin
rpoA 3877905 c.603A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoA 3877909 p.Asn200Ser missense_variant 0.21 rifampicin
rpoA 3877920 c.588G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoA 3877923 c.585C>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoA 3877926 c.582G>C synonymous_variant 0.25 rifampicin
rpoA 3877962 c.546G>T synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoA 3877986 c.522G>C synonymous_variant 0.21 rifampicin
rpoA 3877989 c.519A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoA 3878001 c.507A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoA 3878118 c.390T>C synonymous_variant 0.24 rifampicin
rpoA 3878130 c.378C>G synonymous_variant 0.2 rifampicin
rpoA 3878346 c.162T>C synonymous_variant 0.18 rifampicin
rpoA 3878364 c.144A>T synonymous_variant 0.23 rifampicin
rpoA 3878367 c.141C>G synonymous_variant 0.23 rifampicin
rpoA 3878376 c.132G>C synonymous_variant 0.24 rifampicin
rpoA 3878385 c.123C>G synonymous_variant 0.2 rifampicin
rpoA 3878388 c.120C>G synonymous_variant 0.2 rifampicin
rpoA 3878391 c.117T>C synonymous_variant 0.21 rifampicin
rpoA 3878415 c.93C>T synonymous_variant 0.21 rifampicin
rpoA 3878424 c.84G>C synonymous_variant 0.26 rifampicin
rpoA 3878761 c.-254G>C upstream_gene_variant 0.26 rifampicin
rpoA 3878853 c.-346G>A upstream_gene_variant 0.25 rifampicin
rpoA 3878860 c.-353C>T upstream_gene_variant 0.25 rifampicin
rpoA 3878878 c.-371T>C upstream_gene_variant 0.27 rifampicin Uncertain significance
rpoA 3878909 c.-402A>G upstream_gene_variant 0.23 rifampicin
rpoA 3878914 c.-407T>C upstream_gene_variant 0.23 rifampicin Uncertain significance
rpoA 3878917 c.-410G>A upstream_gene_variant 0.23 rifampicin Uncertain significance
rpoA 3878962 c.-455G>A upstream_gene_variant 0.32 rifampicin Uncertain significance
rpoA 3878968 c.-461T>C upstream_gene_variant 0.3 rifampicin Uncertain significance
rpoA 3878976 c.-469A>G upstream_gene_variant 0.29 rifampicin Uncertain significance
rpoA 3878986 c.-479G>C upstream_gene_variant 0.35 rifampicin
rpoA 3878998 c.-491C>G upstream_gene_variant 0.26 rifampicin Uncertain significance
rpoA 3879079 c.-572A>G upstream_gene_variant 0.25 rifampicin
rpoA 3879088 c.-581A>C upstream_gene_variant 0.2 rifampicin
rpoA 3879094 c.-587T>C upstream_gene_variant 0.25 rifampicin
rpoA 3879121 c.-614T>G upstream_gene_variant 0.36 rifampicin
rpoA 3879127 c.-620T>C upstream_gene_variant 0.37 rifampicin
rpoA 3879154 c.-647T>C upstream_gene_variant 0.24 rifampicin
rpoA 3879160 c.-653A>G upstream_gene_variant 0.29 rifampicin
rpoA 3879178 c.-671T>C upstream_gene_variant 0.33 rifampicin
rpoA 3879190 c.-683C>G upstream_gene_variant 0.31 rifampicin
clpC1 4038812 c.1893T>C synonymous_variant 0.3 pyrazinamide
clpC1 4038821 c.1884G>A synonymous_variant 0.3 pyrazinamide
clpC1 4038845 c.1860G>C synonymous_variant 0.31 pyrazinamide
clpC1 4038860 c.1845G>C synonymous_variant 0.29 pyrazinamide Not assoc w R - Interim
clpC1 4038878 c.1827A>G synonymous_variant 0.29 pyrazinamide Not assoc w R - Interim
clpC1 4038908 c.1797C>G synonymous_variant 0.24 pyrazinamide
clpC1 4038914 c.1791G>C synonymous_variant 0.24 pyrazinamide
clpC1 4038923 c.1780_1782delCTAinsTTG synonymous_variant 0.25 pyrazinamide
clpC1 4039391 c.1314T>G synonymous_variant 0.36 pyrazinamide
clpC1 4039397 c.1308A>G synonymous_variant 0.32 pyrazinamide
clpC1 4039430 c.1275T>C synonymous_variant 0.35 pyrazinamide
clpC1 4039442 c.1263A>G synonymous_variant 0.36 pyrazinamide
clpC1 4039454 c.1251A>G synonymous_variant 0.34 pyrazinamide Not assoc w R - Interim
clpC1 4039589 c.1116G>C synonymous_variant 0.18 pyrazinamide
clpC1 4039610 c.1095G>C synonymous_variant 0.18 pyrazinamide
clpC1 4039616 c.1089G>C synonymous_variant 0.18 pyrazinamide
clpC1 4039661 c.1044T>G synonymous_variant 0.31 pyrazinamide
clpC1 4039664 c.1041G>C synonymous_variant 0.3 pyrazinamide
clpC1 4039694 c.1011G>C synonymous_variant 0.2 pyrazinamide
clpC1 4039724 c.981A>G synonymous_variant 0.4 pyrazinamide
clpC1 4039729 p.Asp326Asn missense_variant 0.59 pyrazinamide Not assoc w R
clpC1 4039751 c.954A>G synonymous_variant 0.36 pyrazinamide
clpC1 4039757 c.948A>G synonymous_variant 0.24 pyrazinamide
clpC1 4039760 c.945T>C synonymous_variant 0.31 pyrazinamide
clpC1 4039766 c.939T>C synonymous_variant 0.29 pyrazinamide
clpC1 4039769 c.936C>G synonymous_variant 0.29 pyrazinamide
clpC1 4039775 c.930G>C synonymous_variant 0.3 pyrazinamide
clpC1 4039778 c.927A>G synonymous_variant 0.3 pyrazinamide
clpC1 4039781 c.924G>C synonymous_variant 0.31 pyrazinamide
clpC1 4039790 c.915C>G synonymous_variant 0.28 pyrazinamide
clpC1 4039817 c.888A>C synonymous_variant 0.3 pyrazinamide Not assoc w R - Interim
clpC1 4039820 c.885T>G synonymous_variant 0.31 pyrazinamide
clpC1 4039952 c.753T>C synonymous_variant 0.16 pyrazinamide
clpC1 4039988 c.717C>G synonymous_variant 0.18 pyrazinamide
clpC1 4039991 c.714G>C synonymous_variant 0.18 pyrazinamide
clpC1 4040021 c.684A>C synonymous_variant 0.24 pyrazinamide Not assoc w R - Interim
clpC1 4040024 c.681A>G synonymous_variant 0.24 pyrazinamide
clpC1 4040033 c.672G>C synonymous_variant 0.25 pyrazinamide
clpC1 4040036 c.669C>G synonymous_variant 0.25 pyrazinamide
clpC1 4040471 c.234T>C synonymous_variant 0.18 pyrazinamide Not assoc w R - Interim
clpC1 4040477 c.228G>C synonymous_variant 0.18 pyrazinamide
clpC1 4040480 c.225T>G synonymous_variant 0.18 pyrazinamide
panD 4044737 c.-456T>C upstream_gene_variant 0.18 pyrazinamide
panD 4044746 c.-467_-465delGTGinsATC upstream_gene_variant 0.2 pyrazinamide
panD 4044752 c.-471T>C upstream_gene_variant 0.2 pyrazinamide
panD 4044779 c.-500_-498delCTAinsTGC upstream_gene_variant 0.18 pyrazinamide
panD 4044788 c.-507G>C upstream_gene_variant 0.19 pyrazinamide
panD 4044791 c.-510G>C upstream_gene_variant 0.19 pyrazinamide
panD 4044800 c.-519C>G upstream_gene_variant 0.2 pyrazinamide
panD 4044812 c.-531A>C upstream_gene_variant 0.2 pyrazinamide
panD 4044818 c.-537G>C upstream_gene_variant 0.19 pyrazinamide
panD 4045019 c.-738G>C upstream_gene_variant 0.18 pyrazinamide
panD 4045022 c.-741C>G upstream_gene_variant 0.18 pyrazinamide
panD 4045028 c.-747C>G upstream_gene_variant 0.18 pyrazinamide
panD 4045034 c.-753A>C upstream_gene_variant 0.2 pyrazinamide
panD 4045055 c.-774T>G upstream_gene_variant 0.2 pyrazinamide
panD 4045067 c.-786C>G upstream_gene_variant 0.19 pyrazinamide
panD 4045070 c.-789C>T upstream_gene_variant 0.18 pyrazinamide
panD 4045076 c.-795A>C upstream_gene_variant 0.17 pyrazinamide
glpK 4138646 c.1110G>C synonymous_variant 0.16 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138654 c.1102C>T synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
glpK 4138670 c.1086G>C synonymous_variant 0.2 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138679 p.Met359Val missense_variant 0.18 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138695 p.Pro354Asp missense_variant 0.18 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138718 c.1038T>C synonymous_variant 0.17 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138721 c.1035G>A synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
streptomycin
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
glpK 4138724 c.1032A>G synonymous_variant 0.16 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138730 c.1026C>G synonymous_variant 0.2 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
embC 4240780 c.918T>C synonymous_variant 0.22 ethambutol
embC 4240783 c.921G>C synonymous_variant 0.22 ethambutol
embC 4240789 c.927T>C synonymous_variant 0.22 ethambutol
embC 4240819 c.957A>G synonymous_variant 0.15 ethambutol
embC 4240828 c.966G>A synonymous_variant 0.16 ethambutol
embC 4240831 c.969T>G synonymous_variant 0.15 ethambutol
embC 4241032 c.1170G>C synonymous_variant 0.17 ethambutol
embC 4241038 c.1176G>C synonymous_variant 0.19 ethambutol
embC 4241047 c.1185C>G synonymous_variant 0.2 ethambutol
embC 4241050 c.1188T>G synonymous_variant 0.2 ethambutol
embC 4241053 c.1191G>C synonymous_variant 0.2 ethambutol
embC 4241089 c.1227C>G synonymous_variant 0.25 ethambutol
embC 4241095 c.1233C>T synonymous_variant 0.24 ethambutol
embC 4241107 c.1245G>C synonymous_variant 0.21 ethambutol
embC 4241146 c.1284C>G synonymous_variant 0.2 ethambutol
embC 4241158 c.1296T>C synonymous_variant 0.22 ethambutol
embC 4241161 c.1299C>G synonymous_variant 0.21 ethambutol Not assoc w R - Interim
embC 4241162 c.1300T>C synonymous_variant 0.21 ethambutol
embC 4241170 c.1308G>C synonymous_variant 0.2 ethambutol
embC 4241173 c.1311C>T synonymous_variant 0.2 ethambutol
embC 4241179 c.1317G>A synonymous_variant 0.2 ethambutol
embC 4241449 c.1587C>G synonymous_variant 0.22 ethambutol
embC 4241453 p.Ile531Val missense_variant 0.2 ethambutol
embC 4241479 c.1617C>G synonymous_variant 0.18 ethambutol
embC 4241480 c.1618T>C synonymous_variant 0.17 ethambutol
embC 4241488 c.1626G>C synonymous_variant 0.22 ethambutol
embC 4241496 p.Ala545Gly missense_variant 0.21 ethambutol
embC 4241500 c.1638A>C synonymous_variant 0.19 ethambutol
embC 4241501 p.Ser547Thr missense_variant 0.2 ethambutol
embC 4241506 c.1644G>C synonymous_variant 0.19 ethambutol
embC 4241518 c.1656A>G synonymous_variant 0.18 ethambutol
embC 4241530 c.1668C>G synonymous_variant 0.15 ethambutol
embC 4241572 c.1710C>G synonymous_variant 0.16 ethambutol
embC 4241591 p.Leu577Val missense_variant 0.22 ethambutol
embC 4241611 c.1749G>C synonymous_variant 0.21 ethambutol
embC 4241614 c.1752A>C synonymous_variant 0.2 ethambutol
embC 4241626 c.1764T>C synonymous_variant 0.22 ethambutol
embC 4241635 c.1773G>C synonymous_variant 0.22 ethambutol
embC 4241644 c.1782G>C synonymous_variant 0.22 ethambutol
embC 4241648 c.1786_1788delTTGinsCTC synonymous_variant 0.22 ethambutol
embC 4241657 p.Ser599Pro missense_variant 0.17 ethambutol
embC 4241665 c.1803G>C synonymous_variant 0.17 ethambutol
embC 4242643 c.2781C>T synonymous_variant 0.94 ethambutol Not assoc w R
embA 4245053 c.1821G>C synonymous_variant 0.16 ethambutol
embA 4245060 c.1828T>C synonymous_variant 0.16 ethambutol
embA 4245083 c.1851A>C synonymous_variant 0.22 ethambutol
embA 4245089 c.1857G>C synonymous_variant 0.22 ethambutol
embA 4245101 c.1869G>C synonymous_variant 0.21 ethambutol
embA 4245137 c.1905T>C synonymous_variant 0.24 ethambutol
embA 4245146 c.1914G>A synonymous_variant 0.2 ethambutol
embA 4245149 c.1917C>G synonymous_variant 0.18 ethambutol
embA 4245153 p.Ile641Val missense_variant 0.2 ethambutol
embA 4245182 c.1950T>C synonymous_variant 0.25 ethambutol
embA 4245189 c.1957C>T synonymous_variant 0.27 ethambutol
embA 4245198 p.Leu656Ile missense_variant 0.26 ethambutol
embA 4245207 c.1975T>C synonymous_variant 0.25 ethambutol
embA 4245215 c.1983A>C synonymous_variant 0.25 ethambutol
embA 4245222 p.Tyr664Gln missense_variant 0.24 ethambutol
embA 4245248 c.2016G>C synonymous_variant 0.22 ethambutol
embA 4245257 c.2025A>G synonymous_variant 0.17 ethambutol
embB 4245725 c.-789A>G upstream_gene_variant 0.15 ethambutol
embB 4245737 c.-777A>C upstream_gene_variant 0.18 ethambutol
embB 4245740 c.-774T>C upstream_gene_variant 0.17 ethambutol
embB 4246292 c.-222A>G upstream_gene_variant 0.17 ethambutol
embA 4246305 p.Ser1025Glu missense_variant 0.16 ethambutol
embA 4246308 p.Thr1026Ala missense_variant 0.16 ethambutol
embB 4246316 c.-198T>G upstream_gene_variant 0.2 ethambutol
embB 4246319 c.-195G>C upstream_gene_variant 0.2 ethambutol
embA 4246329 p.Thr1033Ala missense_variant 0.22 ethambutol
embB 4246349 c.-165C>G upstream_gene_variant 0.2 ethambutol
embA 4246359 p.Ala1043Ser missense_variant 0.17 ethambutol
embB 4246367 c.-147C>T upstream_gene_variant 0.16 ethambutol
embB 4246373 c.-141T>C upstream_gene_variant 0.15 ethambutol
embB 4246376 c.-138G>C upstream_gene_variant 0.15 ethambutol
embA 4246379 c.3147C>T synonymous_variant 0.15 ethambutol Not assoc w R - Interim
embB 4247425 c.912G>C synonymous_variant 0.15 ethambutol
embB 4247434 c.921C>G synonymous_variant 0.16 ethambutol
embB 4247437 c.924A>G synonymous_variant 0.16 ethambutol Not assoc w R - Interim
embB 4247440 c.927C>G synonymous_variant 0.16 ethambutol
embB 4247446 c.933C>T synonymous_variant 0.16 ethambutol
embB 4247464 c.951C>G synonymous_variant 0.2 ethambutol
embB 4247470 c.957T>C synonymous_variant 0.2 ethambutol
embB 4247491 c.978G>C synonymous_variant 0.23 ethambutol
embB 4247497 c.984T>C synonymous_variant 0.26 ethambutol
embB 4247512 c.999T>C synonymous_variant 0.23 ethambutol
embB 4247539 c.1026T>C synonymous_variant 0.18 ethambutol
embB 4247815 c.1302C>G synonymous_variant 0.16 ethambutol
embB 4247819 p.Val436Ile missense_variant 0.16 ethambutol Uncertain significance
embB 4247830 c.1317A>G synonymous_variant 0.17 ethambutol Not assoc w R - Interim
embB 4247836 c.1323A>G synonymous_variant 0.18 ethambutol Not assoc w R - Interim
embB 4247839 c.1326G>C synonymous_variant 0.2 ethambutol Not assoc w R - Interim
embB 4247866 c.1353G>C synonymous_variant 0.3 ethambutol
embB 4247875 c.1362G>C synonymous_variant 0.29 ethambutol
embB 4247876 c.1363C>T synonymous_variant 0.3 ethambutol
embB 4247881 c.1368G>C synonymous_variant 0.3 ethambutol
embB 4247887 c.1374C>T synonymous_variant 0.31 ethambutol Not assoc w R - Interim
embB 4247893 c.1380C>T synonymous_variant 0.32 ethambutol
embB 4247899 p.Met462Ile missense_variant 0.32 ethambutol
embB 4247905 c.1392G>C synonymous_variant 0.32 ethambutol Not assoc w R - Interim
embB 4247909 c.1396T>C synonymous_variant 0.3 ethambutol
embB 4247932 c.1419C>G synonymous_variant 0.25 ethambutol
embB 4247940 p.Leu476Trp missense_variant 0.22 ethambutol
embB 4247945 c.1432T>C synonymous_variant 0.19 ethambutol
embB 4247951 p.Ser480Ala missense_variant 0.18 ethambutol
embB 4247956 c.1443G>C synonymous_variant 0.18 ethambutol Not assoc w R - Interim
embB 4247974 c.1461C>G synonymous_variant 0.16 ethambutol
embB 4248035 p.Val508Ile missense_variant 0.16 ethambutol
embB 4248040 c.1527C>G synonymous_variant 0.16 ethambutol
embB 4248041 p.Ala510Thr missense_variant 0.15 ethambutol Uncertain significance
embB 4248070 c.1557T>C synonymous_variant 0.22 ethambutol
embB 4248085 c.1572T>C synonymous_variant 0.24 ethambutol
embB 4248097 c.1584C>G synonymous_variant 0.26 ethambutol
embB 4248130 c.1617G>C synonymous_variant 0.25 ethambutol
embB 4248133 c.1620C>G synonymous_variant 0.25 ethambutol
embB 4248139 c.1626C>G synonymous_variant 0.24 ethambutol
embB 4248142 c.1629T>C synonymous_variant 0.24 ethambutol
embB 4248143 c.1630T>C synonymous_variant 0.24 ethambutol
embB 4248157 c.1644A>G synonymous_variant 0.24 ethambutol Not assoc w R - Interim
embB 4248220 c.1707A>C synonymous_variant 0.16 ethambutol
embB 4248457 c.1944T>C synonymous_variant 0.15 ethambutol
embB 4249417 c.2904A>G synonymous_variant 0.24 ethambutol
embB 4249423 p.Asp970Glu missense_variant 0.26 ethambutol Uncertain significance
embB 4249424 p.Leu971Met missense_variant 0.27 ethambutol
embB 4249429 c.2916C>T synonymous_variant 0.27 ethambutol
embB 4249432 c.2919A>G synonymous_variant 0.26 ethambutol
embB 4249441 c.2928A>G synonymous_variant 0.26 ethambutol Not assoc w R - Interim
embB 4249444 c.2931T>C synonymous_variant 0.31 ethambutol
embB 4249447 c.2934G>A synonymous_variant 0.29 ethambutol Not assoc w R - Interim
embB 4249469 p.Leu986Met missense_variant 0.28 ethambutol
embB 4249486 c.2973T>G synonymous_variant 0.26 ethambutol
embB 4249498 c.2985G>C synonymous_variant 0.21 ethambutol
embB 4249521 p.Ala1003Val missense_variant 0.21 ethambutol
embB 4249525 c.3012T>C synonymous_variant 0.21 ethambutol Not assoc w R - Interim
embB 4249529 p.Ile1006Val missense_variant 0.21 ethambutol
embB 4249532 p.Ala1007Thr missense_variant 0.22 ethambutol Uncertain significance
embB 4249537 c.3024A>G synonymous_variant 0.21 ethambutol
embB 4249543 c.3030G>C synonymous_variant 0.22 ethambutol
embB 4249546 c.3033G>A synonymous_variant 0.21 ethambutol
embB 4249558 c.3045A>C synonymous_variant 0.16 ethambutol
embB 4249756 c.3243C>T synonymous_variant 1.0 ethambutol
aftB 4267580 c.1257G>T synonymous_variant 0.17 ethambutol
aftB 4267604 c.1233C>G synonymous_variant 0.2 ethambutol
aftB 4267607 c.1230G>A synonymous_variant 0.2 ethambutol
aftB 4267622 c.1215G>C synonymous_variant 0.21 ethambutol
aftB 4267625 c.1212T>C synonymous_variant 0.21 ethambutol
aftB 4267628 c.1209C>G synonymous_variant 0.21 ethambutol
aftB 4267634 p.Arg401His missense_variant 0.22 ethambutol
aftB 4267649 c.1188T>C synonymous_variant 0.24 ethambutol Not assoc w R - Interim
aftB 4268164 p.Gln225Glu missense_variant 0.2 ethambutol
aftB 4268169 p.Ala223Gly missense_variant 0.19 ethambutol
aftB 4268171 c.666G>C synonymous_variant 0.19 ethambutol
aftB 4268179 c.658T>C synonymous_variant 0.2 ethambutol Not assoc w R - Interim
aftB 4268182 p.Phe219Leu missense_variant 0.2 ethambutol
aftB 4268183 c.654A>T synonymous_variant 0.2 ethambutol
aftB 4268193 p.Leu215Ala missense_variant 0.19 ethambutol
aftB 4268225 c.612G>C synonymous_variant 0.15 ethambutol
aftB 4268236 p.Leu201Met missense_variant 0.15 ethambutol
aftB 4269201 c.-365A>G upstream_gene_variant 0.24 ethambutol
ubiA 4269220 p.Ala205Lys missense_variant 0.24 ethambutol
ubiA 4269222 c.612T>C synonymous_variant 0.24 ethambutol Not assoc w R - Interim
aftB 4269242 c.-406C>T upstream_gene_variant 0.28 ethambutol
ubiA 4269243 p.His197Gln missense_variant 0.26 ethambutol
aftB 4269249 c.-413G>A upstream_gene_variant 0.3 ethambutol
aftB 4269258 c.-422C>T upstream_gene_variant 0.3 ethambutol
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R