TB-Profiler result

Run: ERR9786911
Summary

Run ID: ERR9786911

Sample name:

Date: 2024-03-24T19:26:23.643005

Number of reads: 655457

Percentage reads mapped: 66.53

Median coverage: 28.0

Strain: lineage4.1.2.1

Spoligotype:

Drug-resistance: HR-TB

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage4.1 Euro-American None 0.98
lineage4.1.2 Euro-American None 1.0
lineage4.1.2.1 Euro-American (Haarlem) RD182 1.0
lineage4 Euro-American None 1.0
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid katG p.Ser315Thr Assoc w R High-level resistance
ethambutol
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
katG 2155168 p.Ser315Thr missense_variant 1.0 isoniazid Assoc w R High-level resistance
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
gyrB 6178 c.939C>T synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrB 6181 c.942C>T synonymous_variant 0.32 levofloxacin
moxifloxacin
gyrB 6184 c.945C>G synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrB 6193 c.954G>A synonymous_variant 0.31 levofloxacin
moxifloxacin
gyrB 6203 p.Ser322Ala missense_variant 0.3 levofloxacin
moxifloxacin
gyrB 6214 c.975G>C synonymous_variant 0.31 levofloxacin
moxifloxacin
gyrB 6215 p.Ser326Thr missense_variant 0.28 levofloxacin
moxifloxacin
gyrB 6223 c.984G>C synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6234 c.995_996insGCGCGA disruptive_inframe_insertion 0.25 levofloxacin
moxifloxacin
gyrB 6238 c.1000_1005delGACCGC conservative_inframe_deletion 0.28 levofloxacin
moxifloxacin
gyrB 6250 c.1011A>G synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6259 p.Asp340Glu missense_variant 0.26 levofloxacin
moxifloxacin
gyrB 6265 p.Asp342Glu missense_variant 0.26 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrB 6266 p.Pro343Ala missense_variant 0.26 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrB 6286 c.1047T>C synonymous_variant 0.31 levofloxacin
moxifloxacin
gyrB 6292 c.1053G>T synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrB 6301 c.1062G>C synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrB 6326 c.1087_1089delAGCinsCG frameshift_variant&missense_variant 0.27 levofloxacin Uncertain significance
moxifloxacin
gyrB 6329 p.Glu364Gln missense_variant 0.27 levofloxacin
moxifloxacin
gyrA 6334 c.-968G>C upstream_gene_variant 0.27 levofloxacin
moxifloxacin
gyrA 6362 c.-940T>C upstream_gene_variant 0.24 levofloxacin
moxifloxacin
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7565 c.264C>T synonymous_variant 0.31 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7571 c.270G>C synonymous_variant 0.36 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7592 c.291G>C synonymous_variant 0.38 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7622 c.321C>T synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 7631 c.330G>C synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 7637 c.336C>T synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrA 7658 c.357A>G synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 7661 c.360C>T synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 7664 c.363T>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 7670 c.369A>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 7671 p.Pro124Ala missense_variant 0.22 levofloxacin
moxifloxacin
gyrA 7676 c.375G>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 7679 c.378G>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 7683 c.382_384delAGGinsCT frameshift_variant&missense_variant 0.23 levofloxacin
moxifloxacin
gyrA 7694 c.393A>G synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 7703 c.402G>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 7710 c.409T>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 7715 c.414G>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8810 c.1509A>C synonymous_variant 0.35 levofloxacin
moxifloxacin
gyrA 8818 p.Ser506Thr missense_variant 0.35 levofloxacin
moxifloxacin
gyrA 8897 c.1596T>C synonymous_variant 0.42 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8900 c.1599G>C synonymous_variant 0.41 levofloxacin
moxifloxacin
gyrA 8903 c.1602T>C synonymous_variant 0.41 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8912 c.1611G>A synonymous_variant 0.42 levofloxacin
moxifloxacin
gyrA 8915 c.1614A>G synonymous_variant 0.42 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8924 c.1623C>T synonymous_variant 0.44 levofloxacin
moxifloxacin
gyrA 8939 c.1638T>C synonymous_variant 0.38 levofloxacin
moxifloxacin
gyrA 8942 c.1641G>C synonymous_variant 0.38 levofloxacin
moxifloxacin
gyrA 8946 c.1645_1647delTTGinsCC frameshift_variant&missense_variant 0.38 levofloxacin
moxifloxacin
gyrA 8967 p.Ala556Asn missense_variant 0.4 levofloxacin
moxifloxacin
gyrA 8990 c.1689C>G synonymous_variant 0.39 levofloxacin
moxifloxacin
gyrA 8996 c.1695T>C synonymous_variant 0.36 levofloxacin
moxifloxacin
gyrA 8998 p.Leu566Trp missense_variant 0.36 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9014 c.1713C>G synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrA 9017 c.1716C>G synonymous_variant 0.31 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9023 c.1722A>C synonymous_variant 0.31 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9029 c.1728T>G synonymous_variant 0.32 levofloxacin
moxifloxacin
gyrA 9032 c.1731T>C synonymous_variant 0.32 levofloxacin
moxifloxacin
gyrA 9304 p.Gly668Glu missense_variant 1.0 levofloxacin
moxifloxacin
fgd1 491591 p.Lys270Met missense_variant 1.0 clofazimine Not assoc w R
pretomanid
delamanid Uncertain significance
mshA 575679 p.Asn111Ser missense_variant 1.0 ethionamide Not assoc w R
isoniazid Not assoc w R
Rv0565c 657269 p.Ser68Pro missense_variant 1.0 ethionamide Uncertain significance
nusG 734508 c.255C>G synonymous_variant 0.23 rifampicin
nusG 734532 c.279A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
nusG 734541 c.288A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760115 c.309C>T synonymous_variant 0.96 rifampicin Not assoc w R
rpoB 762083 c.2277T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 762086 c.2280G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 762101 c.2295C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 762114 p.Ile770Val missense_variant 0.25 rifampicin Uncertain significance
rpoB 762131 c.2325C>G synonymous_variant 0.22 rifampicin
rpoB 762134 c.2328C>T synonymous_variant 0.22 rifampicin
rpoB 762140 c.2334G>C synonymous_variant 0.22 rifampicin
rpoB 762143 c.2337T>C synonymous_variant 0.22 rifampicin
rpoB 762149 c.2343G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 762158 c.2352G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 762167 c.2361T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 762176 c.2370T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 762239 c.2433G>A synonymous_variant 0.25 rifampicin
rpoB 762245 c.2439G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 762249 c.2443C>T synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 762959 c.3153G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 762962 c.3156C>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 763495 c.126G>A synonymous_variant 0.15 rifampicin
rpoC 763528 c.159G>A synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 763573 c.204G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 763589 p.Ile74Val missense_variant 0.22 rifampicin
rpoC 763603 c.234C>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 763618 c.249C>T synonymous_variant 0.21 rifampicin
rpoC 764353 c.984G>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 764387 c.1018T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764405 c.1036_1038delAGGinsCC frameshift_variant&missense_variant 0.19 rifampicin
rpoC 764410 c.1041G>C synonymous_variant 0.24 rifampicin
rpoC 764429 c.1060C>T synonymous_variant 0.28 rifampicin
rpoC 764434 c.1065A>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764435 c.1066_1068delAGGinsCA frameshift_variant&missense_variant 0.28 rifampicin
rpoC 764446 c.1077T>C synonymous_variant 0.25 rifampicin
rpoC 764449 c.1080G>C synonymous_variant 0.24 rifampicin
rpoC 764458 c.1089G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 764461 c.1092A>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 764485 c.1116G>C synonymous_variant 0.3 rifampicin
rpoC 764497 c.1128A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 764500 c.1131C>G synonymous_variant 0.26 rifampicin
rpoC 764506 c.1137C>T synonymous_variant 0.31 rifampicin
rpoC 764521 c.1152T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 764527 c.1158C>T synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 764530 c.1161C>T synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 764539 c.1170C>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764548 c.1179G>C synonymous_variant 0.26 rifampicin
rpoC 764575 c.1206T>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 764581 c.1212T>C synonymous_variant 0.27 rifampicin
rpoC 764605 c.1236G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764611 c.1242G>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764623 c.1254C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 764626 c.1257C>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 764632 c.1263T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 765150 p.Gly594Glu missense_variant 1.0 rifampicin Not assoc w R
rpoC 766996 c.3627C>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 767008 c.3639G>A synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 767020 c.3651C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 767092 c.3723C>T synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 767098 c.3729T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 767104 c.3735C>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 767105 c.3736_3738delAACinsCG frameshift_variant&missense_variant 0.26 rifampicin
rpoC 767119 c.3750A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 767134 c.3765C>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 767138 c.3769C>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 767149 c.3780C>T synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 767155 c.3786C>G synonymous_variant 0.23 rifampicin
rpoC 767158 c.3789T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 767167 c.3798C>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 767180 p.Ala1271Gln missense_variant 0.29 rifampicin
rpoC 767185 c.3816G>C synonymous_variant 0.28 rifampicin
rpoC 767191 c.3822C>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 767200 c.3831G>A synonymous_variant 0.29 rifampicin
rpoC 767221 c.3852C>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 767230 c.3861G>T synonymous_variant 0.21 rifampicin
rpoC 767233 c.3864T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
mmpL5 775639 p.Ile948Val missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781658 c.99A>G synonymous_variant 0.24 streptomycin
rpsL 781682 c.123T>C synonymous_variant 0.19 streptomycin
rpsL 781685 c.126G>C synonymous_variant 0.2 streptomycin
rpsL 781706 c.147T>G synonymous_variant 0.22 streptomycin
rpsL 781709 c.150G>C synonymous_variant 0.22 streptomycin Not assoc w R - Interim
rpsL 781715 c.156T>C synonymous_variant 0.21 streptomycin
rpsL 781721 c.162C>T synonymous_variant 0.17 streptomycin
rpsL 781728 c.169T>C synonymous_variant 0.17 streptomycin
rpsL 781736 c.177T>C synonymous_variant 0.2 streptomycin
rpsL 781742 c.183C>T synonymous_variant 0.19 streptomycin
rpsL 781754 c.195G>C synonymous_variant 0.2 streptomycin
rpsL 781760 c.201T>C synonymous_variant 0.2 streptomycin
rpsL 781802 c.243G>C synonymous_variant 0.19 streptomycin
rpsL 781808 c.249C>T synonymous_variant 0.19 streptomycin
rpsL 781814 c.255C>T synonymous_variant 0.19 streptomycin
rpsL 781817 c.258G>T synonymous_variant 0.19 streptomycin
rpsL 781829 c.270G>C synonymous_variant 0.24 streptomycin
rpsL 781832 c.273T>C synonymous_variant 0.25 streptomycin
rpsL 781859 c.300T>C synonymous_variant 0.24 streptomycin Not assoc w R - Interim
rpsL 781865 c.306G>C synonymous_variant 0.23 streptomycin
rpsL 781868 c.309T>C synonymous_variant 0.23 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.23 streptomycin
fbiC 1304634 c.1704C>G synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1304640 c.1710A>C synonymous_variant 0.16 clofazimine
pretomanid
delamanid
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471986 n.141C>T non_coding_transcript_exon_variant 0.37 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472019 n.174G>A non_coding_transcript_exon_variant 0.39 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472031 n.186G>C non_coding_transcript_exon_variant 0.39 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472033 n.188A>C non_coding_transcript_exon_variant 0.39 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472035 n.190G>T non_coding_transcript_exon_variant 0.39 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472040 n.195T>G non_coding_transcript_exon_variant 0.38 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472041 n.196C>T non_coding_transcript_exon_variant 0.38 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472042 n.197T>G non_coding_transcript_exon_variant 0.38 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472053 n.211_212delGC non_coding_transcript_exon_variant 0.41 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472061 n.216A>T non_coding_transcript_exon_variant 0.43 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472075 n.230A>G non_coding_transcript_exon_variant 0.4 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472106 n.261G>A non_coding_transcript_exon_variant 0.36 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.36 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472150 n.305T>A non_coding_transcript_exon_variant 0.44 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472251 n.406G>A non_coding_transcript_exon_variant 0.41 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472289 n.444T>G non_coding_transcript_exon_variant 0.42 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472290 n.445C>G non_coding_transcript_exon_variant 0.42 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472298 n.453_468delGTCCGGGTTCTCTCGGinsCGTA non_coding_transcript_exon_variant 0.44 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472315 n.470T>G non_coding_transcript_exon_variant 0.42 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472324 n.479G>C non_coding_transcript_exon_variant 0.44 streptomycin Uncertain significance
kanamycin
capreomycin
amikacin
rrs 1472325 n.480G>C non_coding_transcript_exon_variant 0.43 streptomycin Uncertain significance
kanamycin
capreomycin
amikacin
rrs 1472446 n.601T>A non_coding_transcript_exon_variant 0.56 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472452 n.607G>A non_coding_transcript_exon_variant 0.55 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472464 n.619A>G non_coding_transcript_exon_variant 0.43 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472672 n.830delT non_coding_transcript_exon_variant 0.54 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472847 n.1002G>C non_coding_transcript_exon_variant 0.27 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472848 n.1003T>G non_coding_transcript_exon_variant 0.27 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472849 n.1004C>G non_coding_transcript_exon_variant 0.27 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472850 n.1005T>C non_coding_transcript_exon_variant 0.27 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472857 n.1012A>G non_coding_transcript_exon_variant 0.27 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472858 n.1013G>T non_coding_transcript_exon_variant 0.25 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472859 n.1014G>C non_coding_transcript_exon_variant 0.26 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472860 n.1015C>G non_coding_transcript_exon_variant 0.26 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472956 n.1111T>C non_coding_transcript_exon_variant 0.56 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472957 n.1112C>T non_coding_transcript_exon_variant 0.55 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472969 n.1124A>G non_coding_transcript_exon_variant 0.46 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472970 n.1125C>G non_coding_transcript_exon_variant 0.45 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472973 n.1128A>T non_coding_transcript_exon_variant 0.45 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472977 n.1132G>C non_coding_transcript_exon_variant 0.47 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472978 n.1133T>C non_coding_transcript_exon_variant 0.48 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472989 n.1144G>A non_coding_transcript_exon_variant 0.48 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472990 n.1145A>G non_coding_transcript_exon_variant 0.48 streptomycin Uncertain significance
kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1473104 n.1259C>T non_coding_transcript_exon_variant 0.48 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473110 n.1265T>G non_coding_transcript_exon_variant 0.48 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473111 n.1266A>G non_coding_transcript_exon_variant 0.49 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473123 n.1278delAinsTC non_coding_transcript_exon_variant 0.48 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473276 n.1431A>G non_coding_transcript_exon_variant 0.33 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473290 n.1445C>T non_coding_transcript_exon_variant 0.25 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473291 n.1446_1447insT non_coding_transcript_exon_variant 0.27 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473301 n.1456T>C non_coding_transcript_exon_variant 0.28 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrl 1473743 n.86C>T non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1473746 n.89T>C non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid
rrl 1473758 n.101G>T non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid
rrl 1473770 n.113T>G non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473806 n.149C>T non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473815 n.158T>C non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473832 n.175C>T non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid
rrl 1473839 n.182G>T non_coding_transcript_exon_variant 0.34 capreomycin
linezolid
rrl 1473876 n.219G>A non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473898 n.241C>T non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473899 n.242A>G non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473916 n.259C>A non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473922 n.265A>T non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1473923 n.266C>G non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473935 n.278C>T non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
rrl 1473937 n.280C>T non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid
rrl 1473943 n.286G>T non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid
rrl 1473945 n.288T>A non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid
rrl 1473946 n.289A>T non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid
rrl 1474022 n.365G>A non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
rrl 1474034 n.377G>A non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1474045 n.388C>T non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid
rrl 1474054 n.397T>C non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid
rrl 1474065 n.408C>G non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid
rrl 1474074 n.417C>T non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474077 n.420G>C non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1474135 n.478G>A non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474140 n.483C>T non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474156 n.499G>A non_coding_transcript_exon_variant 0.31 capreomycin
linezolid
rrl 1474163 n.506C>T non_coding_transcript_exon_variant 0.32 capreomycin
linezolid
rrl 1474178 n.522dupC non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1474181 n.524C>T non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid
rrl 1474183 n.527delC non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474287 n.630_646delTCCTTTTCCTCTCCGGAinsCTCCTTT non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1474308 n.653_654delTG non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1474362 n.705A>G non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474376 n.719T>G non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1474387 n.730C>T non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474447 n.790G>A non_coding_transcript_exon_variant 0.35 capreomycin
linezolid
rrl 1474632 n.975G>T non_coding_transcript_exon_variant 0.51 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474636 n.979A>T non_coding_transcript_exon_variant 0.49 capreomycin Uncertain significance
linezolid
rrl 1474637 n.980C>T non_coding_transcript_exon_variant 0.49 capreomycin Uncertain significance
linezolid
rrl 1474638 n.981C>G non_coding_transcript_exon_variant 0.49 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474639 n.982G>C non_coding_transcript_exon_variant 0.49 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474672 n.1015C>T non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474673 n.1016T>C non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474676 n.1019T>C non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474709 n.1053_1056delTGGT non_coding_transcript_exon_variant 0.42 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474715 n.1060_1061insGACAAA non_coding_transcript_exon_variant 0.41 capreomycin
linezolid
rrl 1474753 n.1096A>G non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid
rrl 1474760 n.1103A>G non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474783 n.1126G>A non_coding_transcript_exon_variant 0.42 capreomycin
linezolid
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474830 n.1173A>G non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475031 n.1374G>T non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid
rrl 1475061 n.1404C>A non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid
rrl 1475062 n.1405A>T non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid
rrl 1475108 n.1451C>G non_coding_transcript_exon_variant 0.35 capreomycin
linezolid
rrl 1475355 n.1698C>T non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475358 n.1701T>C non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1475363 n.1706C>T non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid
rrl 1475369 n.1712G>T non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1475375 n.1718G>A non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid
rrl 1475376 n.1719A>C non_coding_transcript_exon_variant 0.22 capreomycin
linezolid Uncertain significance
rrl 1475379 n.1722G>A non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1475398 n.1741C>T non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1475419 n.1762C>T non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid
rrl 1475429 n.1772G>A non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475430 n.1773T>G non_coding_transcript_exon_variant 0.36 capreomycin
linezolid
rrl 1475452 n.1795C>A non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475479 n.1822C>T non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475480 n.1823A>G non_coding_transcript_exon_variant 0.41 capreomycin
linezolid
rrl 1475487 n.1830C>T non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid
rrl 1475505 n.1848G>A non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475531 n.1874C>T non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475544 n.1887A>T non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475753 n.2096C>T non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid
rrl 1475760 n.2103_2107delCCGCAinsTCCTTCG non_coding_transcript_exon_variant 0.38 capreomycin
linezolid
rrl 1475765 n.2108A>G non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.58 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1475989 n.2332T>A non_coding_transcript_exon_variant 0.58 capreomycin
linezolid
rrl 1476044 n.2387T>G non_coding_transcript_exon_variant 0.42 capreomycin Uncertain significance
linezolid
rrl 1476045 n.2388G>T non_coding_transcript_exon_variant 0.42 capreomycin Uncertain significance
linezolid
rrl 1476047 n.2390G>T non_coding_transcript_exon_variant 0.42 capreomycin
linezolid
rrl 1476049 n.2392C>T non_coding_transcript_exon_variant 0.42 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476088 n.2431A>T non_coding_transcript_exon_variant 0.5 capreomycin
linezolid
rrl 1476099 n.2442A>G non_coding_transcript_exon_variant 0.56 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476103 n.2446C>G non_coding_transcript_exon_variant 0.56 capreomycin Uncertain significance
linezolid
rrl 1476105 n.2448G>C non_coding_transcript_exon_variant 0.56 capreomycin
linezolid
rrl 1476106 n.2449A>T non_coding_transcript_exon_variant 0.56 capreomycin Uncertain significance
linezolid
rrl 1476110 n.2453G>C non_coding_transcript_exon_variant 0.56 capreomycin Uncertain significance
linezolid
rrl 1476114 n.2457T>C non_coding_transcript_exon_variant 0.55 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476115 n.2458T>C non_coding_transcript_exon_variant 0.55 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476131 n.2474C>T non_coding_transcript_exon_variant 0.51 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476214 n.2557G>T non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476215 n.2558C>T non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.56 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476251 n.2594T>G non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid
rrl 1476256 n.2599A>T non_coding_transcript_exon_variant 0.48 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476260 n.2603A>G non_coding_transcript_exon_variant 0.51 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.53 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476583 n.2926G>C non_coding_transcript_exon_variant 0.31 capreomycin
linezolid
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.3 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476597 n.2940G>A non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid
rrl 1476619 n.2962C>T non_coding_transcript_exon_variant 0.28 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476665 n.3008T>C non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid
rrl 1476666 n.3009C>T non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid Uncertain significance
inhA 1674582 c.381T>C synonymous_variant 0.23 ethionamide
isoniazid
inhA 1674585 c.384T>C synonymous_variant 0.23 ethionamide
isoniazid
inhA 1674589 p.Met130Leu missense_variant 0.27 ethionamide
isoniazid
inhA 1674600 c.399G>C synonymous_variant 0.24 ethionamide
isoniazid
inhA 1674619 p.Pro140Glu missense_variant 0.21 ethionamide
isoniazid
inhA 1674624 c.423A>C synonymous_variant 0.2 ethionamide
isoniazid
inhA 1674627 c.426T>C synonymous_variant 0.21 ethionamide
isoniazid
inhA 1674628 p.Ser143Gly missense_variant 0.21 ethionamide
isoniazid
inhA 1674789 c.588G>C synonymous_variant 0.19 ethionamide
isoniazid
inhA 1674795 c.594G>C synonymous_variant 0.21 ethionamide
isoniazid
rpsA 1833664 c.123C>G synonymous_variant 0.19 pyrazinamide
rpsA 1833676 c.135A>G synonymous_variant 0.22 pyrazinamide
rpsA 1833685 c.144G>T synonymous_variant 0.24 pyrazinamide
rpsA 1833694 c.153G>C synonymous_variant 0.21 pyrazinamide
rpsA 1833697 c.156C>G synonymous_variant 0.21 pyrazinamide
rpsA 1833724 c.183C>T synonymous_variant 0.22 pyrazinamide
rpsA 1833727 c.186G>C synonymous_variant 0.22 pyrazinamide
rpsA 1833730 c.189C>T synonymous_variant 0.23 pyrazinamide
rpsA 1833733 c.192C>T synonymous_variant 0.23 pyrazinamide
rpsA 1833734 c.193_195delGCCinsTT frameshift_variant&missense_variant 0.23 pyrazinamide Uncertain significance
rpsA 1833745 c.204G>T synonymous_variant 0.22 pyrazinamide
rpsA 1834255 c.714C>G synonymous_variant 0.23 pyrazinamide
rpsA 1834261 c.720A>G synonymous_variant 0.23 pyrazinamide Not assoc w R - Interim
rpsA 1834264 c.723G>C synonymous_variant 0.23 pyrazinamide
rpsA 1834330 c.789C>G synonymous_variant 0.32 pyrazinamide
rpsA 1834408 c.867C>T synonymous_variant 0.24 pyrazinamide
rpsA 1834411 c.870T>C synonymous_variant 0.26 pyrazinamide
rpsA 1834423 c.882G>T synonymous_variant 0.22 pyrazinamide
rpsA 1834432 c.891G>C synonymous_variant 0.21 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.24 pyrazinamide
rpsA 1834483 c.942G>A synonymous_variant 0.24 pyrazinamide
rpsA 1834489 c.948T>C synonymous_variant 0.23 pyrazinamide
rpsA 1834520 p.Ala327Ser missense_variant 0.21 pyrazinamide
rpsA 1834540 c.999G>C synonymous_variant 0.21 pyrazinamide
rpsA 1834543 c.1002C>G synonymous_variant 0.21 pyrazinamide
rpsA 1834546 c.1005T>C synonymous_variant 0.21 pyrazinamide
rpsA 1834554 c.1014_1015delTG frameshift_variant 0.24 pyrazinamide Uncertain significance
rpsA 1834558 c.1017_1018insAG frameshift_variant 0.24 pyrazinamide Uncertain significance
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
katG 2156607 c.-497delA upstream_gene_variant 1.0 isoniazid Uncertain significance
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
kasA 2517917 c.-198G>C upstream_gene_variant 0.23 isoniazid
kasA 2518076 c.-39C>T upstream_gene_variant 1.0 isoniazid
ribD 2986827 c.-12G>A upstream_gene_variant 1.0 para-aminosalicylic_acid
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
mtrB 3625065 p.Met517Leu missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
mtrA 3626804 c.546A>G synonymous_variant 0.21 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626966 c.-353C>A upstream_gene_variant 0.22 bedaquiline
rifampicin
mtrB 3626969 c.-356C>G upstream_gene_variant 0.24 bedaquiline
rifampicin
rpoA 3878143 p.Gly122Asp missense_variant 0.25 rifampicin Uncertain significance
rpoA 3878145 c.363C>G synonymous_variant 0.26 rifampicin
rpoA 3878154 c.354G>C synonymous_variant 0.24 rifampicin
rpoA 3878157 c.351C>G synonymous_variant 0.25 rifampicin
rpoA 3878160 c.348C>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoA 3878163 c.345C>T synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoA 3878172 c.336G>C synonymous_variant 0.33 rifampicin
rpoA 3878184 c.324C>T synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoA 3878193 c.315T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoA 3878196 p.Glu104Ala missense_variant 0.33 rifampicin Uncertain significance
rpoA 3878205 c.303T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoA 3878217 c.291A>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoA 3878244 c.264G>A synonymous_variant 0.43 rifampicin
rpoA 3878256 c.252G>C synonymous_variant 0.45 rifampicin
rpoA 3878264 p.Ser82Gly missense_variant 0.48 rifampicin
rpoA 3878271 c.237T>C synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoA 3878283 p.Glu75Asp missense_variant 0.5 rifampicin Uncertain significance
rpoA 3878292 c.216T>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoA 3878298 c.210A>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
clpC1 4038410 c.2295C>T synonymous_variant 0.14 pyrazinamide
clpC1 4038445 p.Ala754Thr missense_variant 0.14 pyrazinamide
clpC1 4038485 p.Gly740Lys missense_variant 0.15 pyrazinamide
clpC1 4038490 p.Ala739Ser missense_variant 0.15 pyrazinamide
clpC1 4038491 c.2214C>G synonymous_variant 0.15 pyrazinamide
clpC1 4038499 p.Ser736Gly missense_variant 0.16 pyrazinamide
clpC1 4038917 c.1788C>T synonymous_variant 0.16 pyrazinamide
clpC1 4038923 c.1782A>G synonymous_variant 0.16 pyrazinamide
clpC1 4038941 c.1764G>C synonymous_variant 0.15 pyrazinamide
clpC1 4039001 c.1702_1704delAACinsGG frameshift_variant&missense_variant 0.16 pyrazinamide
clpC1 4039016 c.1689C>G synonymous_variant 0.15 pyrazinamide
clpC1 4039022 c.1683A>G synonymous_variant 0.18 pyrazinamide
clpC1 4039073 c.1632C>T synonymous_variant 0.18 pyrazinamide
clpC1 4039079 c.1626C>G synonymous_variant 0.18 pyrazinamide Not assoc w R - Interim
clpC1 4039085 c.1620A>G synonymous_variant 0.2 pyrazinamide
clpC1 4039091 c.1614G>C synonymous_variant 0.21 pyrazinamide
clpC1 4039169 p.Glu512Asp missense_variant 0.2 pyrazinamide
clpC1 4039178 c.1527G>C synonymous_variant 0.24 pyrazinamide
clpC1 4039183 c.1522T>C synonymous_variant 0.25 pyrazinamide
clpC1 4039187 c.1518G>T synonymous_variant 0.25 pyrazinamide
clpC1 4039190 c.1515C>G synonymous_variant 0.25 pyrazinamide
clpC1 4039208 c.1497C>G synonymous_variant 0.27 pyrazinamide
clpC1 4039217 c.1488G>C synonymous_variant 0.26 pyrazinamide
clpC1 4039244 c.1461G>C synonymous_variant 0.25 pyrazinamide
clpC1 4039274 c.1431G>C synonymous_variant 0.3 pyrazinamide Not assoc w R - Interim
clpC1 4039286 c.1419T>G synonymous_variant 0.27 pyrazinamide
clpC1 4039292 c.1413C>T synonymous_variant 0.26 pyrazinamide
clpC1 4039295 c.1410A>G synonymous_variant 0.2 pyrazinamide
clpC1 4039310 c.1395A>G synonymous_variant 0.18 pyrazinamide
clpC1 4039313 c.1392C>G synonymous_variant 0.18 pyrazinamide
clpC1 4039319 c.1386T>G synonymous_variant 0.18 pyrazinamide
clpC1 4039322 c.1383T>C synonymous_variant 0.18 pyrazinamide
clpC1 4039328 c.1377A>C synonymous_variant 0.18 pyrazinamide
clpC1 4039337 c.1368A>G synonymous_variant 0.21 pyrazinamide
clpC1 4039391 c.1314T>C synonymous_variant 0.15 pyrazinamide
clpC1 4039409 c.1296T>C synonymous_variant 0.15 pyrazinamide
clpC1 4039415 p.Glu430Asp missense_variant 0.15 pyrazinamide Uncertain significance
clpC1 4039610 c.1095G>T synonymous_variant 0.17 pyrazinamide
clpC1 4039616 c.1089G>C synonymous_variant 0.19 pyrazinamide
clpC1 4039622 c.1083C>T synonymous_variant 0.19 pyrazinamide
clpC1 4039646 c.1059G>A synonymous_variant 0.16 pyrazinamide
clpC1 4039649 c.1056G>C synonymous_variant 0.16 pyrazinamide
clpC1 4039652 c.1053G>C synonymous_variant 0.17 pyrazinamide
clpC1 4039661 c.1044T>C synonymous_variant 0.18 pyrazinamide
clpC1 4039670 c.1035G>C synonymous_variant 0.15 pyrazinamide
clpC1 4039682 c.1023C>G synonymous_variant 0.16 pyrazinamide
clpC1 4039691 c.1014G>C synonymous_variant 0.16 pyrazinamide
clpC1 4039694 c.1011G>C synonymous_variant 0.16 pyrazinamide
clpC1 4039724 c.981A>G synonymous_variant 0.17 pyrazinamide
clpC1 4039733 c.972G>C synonymous_variant 0.17 pyrazinamide
clpC1 4039748 c.957G>C synonymous_variant 0.15 pyrazinamide
clpC1 4039751 c.954A>G synonymous_variant 0.16 pyrazinamide
embC 4239298 c.-565C>T upstream_gene_variant 1.0 ethambutol Not assoc w R
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
embC 4242803 p.Val981Leu missense_variant 1.0 ethambutol Not assoc w R
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 capreomycin
amikacin
kanamycin