TB-Profiler result

Run: ERR11465511
Summary

Run ID: ERR11465511

Sample name:

Date: 2024-04-16T06:37:36.234171

Number of reads: 1362538

Percentage reads mapped: 80.98

Median coverage: 31.0

Strain: lineage4.3.4.2.1

Spoligotype:

Drug-resistance: Other

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage4.3 Euro-American (LAM) None 1.0
lineage4 Euro-American None 1.0
lineage4.3.4.2.1 Euro-American (LAM) RD174 0.92
lineage4.3.4 Euro-American (LAM) RD174 1.0
lineage4.3.4.2 Euro-American (LAM) RD174 0.92
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid fbiC c.601_603delATGinsCC Assoc w R - Interim Confers DLM-PMD cross-resistance
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
fbiC 1303531 c.601_603delATGinsCC frameshift_variant&missense_variant 0.21 pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
gyrB 5611 c.372C>T synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6140 p.Val301Leu missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 6709 c.-593A>G upstream_gene_variant 0.2 levofloxacin
moxifloxacin
gyrA 6724 c.-578G>C upstream_gene_variant 0.15 levofloxacin
moxifloxacin
gyrA 6730 c.-572A>G upstream_gene_variant 0.19 levofloxacin
moxifloxacin
gyrB 6745 c.1506T>C synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6760 c.-542G>C upstream_gene_variant 0.15 levofloxacin
moxifloxacin
gyrA 6775 c.-527G>T upstream_gene_variant 0.15 levofloxacin
moxifloxacin
gyrB 6793 c.1554T>C synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6797 p.Gly520Ser missense_variant 0.22 levofloxacin
moxifloxacin
gyrB 6808 c.1569C>G synonymous_variant 0.27 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6811 c.1572C>T synonymous_variant 0.28 levofloxacin
moxifloxacin Not assoc w R - Interim
gyrA 6838 c.-464C>A upstream_gene_variant 0.25 levofloxacin
moxifloxacin
gyrB 6841 c.1602T>C synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6844 c.-458T>C upstream_gene_variant 0.25 levofloxacin
moxifloxacin
gyrB 6856 c.1617T>C synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6862 c.1623C>G synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7355 c.54T>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7406 c.105G>T synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7760 c.459C>T synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 7763 c.462T>A synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 7784 c.483A>G synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 7793 c.492G>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 7796 c.495G>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 7799 c.498A>G synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7802 c.501C>G synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 7814 c.513C>G synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7832 c.531G>T synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 7835 c.534A>G synonymous_variant 0.28 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7841 c.540C>G synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrA 8619 c.1318T>C synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8915 c.1614A>G synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8930 c.1629C>T synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8996 c.1695T>C synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 8998 p.Leu566Trp missense_variant 0.27 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9023 c.1722A>C synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9029 c.1728T>G synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 9032 c.1731T>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 9038 c.1737C>G synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 9050 p.Asp583Glu missense_variant 0.21 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9056 c.1755C>G synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9062 c.1761C>G synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 9068 c.1767G>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 9080 c.1779G>T synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrA 9089 c.1788G>C synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrA 9092 c.1791C>G synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrA 9099 c.1798_1800delTTAinsCG frameshift_variant&missense_variant 0.26 levofloxacin
moxifloxacin
gyrA 9114 c.1813_1815delGAGinsAC frameshift_variant&missense_variant 0.24 levofloxacin
moxifloxacin
gyrA 9119 c.1818A>G synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 9128 c.1827C>G synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 9304 p.Gly668Glu missense_variant 1.0 levofloxacin
moxifloxacin
gyrA 9332 p.Asn677Lys missense_variant 0.35 levofloxacin
moxifloxacin
gyrA 9335 c.2034G>C synonymous_variant 0.32 levofloxacin
moxifloxacin
gyrA 9341 c.2040C>G synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 9345 c.2044A>C synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 9353 c.2052G>C synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 9356 c.2055G>C synonymous_variant 0.25 levofloxacin
moxifloxacin
mshA 575782 c.435G>C synonymous_variant 0.23 ethionamide
isoniazid
mshA 575821 c.474G>C synonymous_variant 0.21 ethionamide
isoniazid
mshA 575842 c.495G>C synonymous_variant 0.17 ethionamide
isoniazid
mshA 575845 c.498C>G synonymous_variant 0.19 ethionamide
isoniazid
ccsA 620694 c.804C>G synonymous_variant 0.24 capreomycin
amikacin
kanamycin
ccsA 620712 c.822G>C synonymous_variant 0.21 capreomycin
amikacin
kanamycin
ccsA 620718 c.828G>C synonymous_variant 0.22 capreomycin
amikacin
kanamycin
ccsA 620721 c.831G>C synonymous_variant 0.23 capreomycin
amikacin
kanamycin
ccsA 620733 c.843G>C synonymous_variant 0.26 capreomycin
amikacin
kanamycin
ccsA 620736 c.846G>C synonymous_variant 0.26 capreomycin
amikacin
kanamycin
ccsA 620739 c.849A>G synonymous_variant 0.24 capreomycin
amikacin
kanamycin
ccsA 620745 c.855G>C synonymous_variant 0.24 capreomycin
amikacin
kanamycin
ccsA 620748 c.858T>G synonymous_variant 0.24 capreomycin
amikacin
kanamycin
ccsA 620769 c.879C>G synonymous_variant 0.25 capreomycin Not assoc w R - Interim
amikacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
nusG 734499 c.246G>C synonymous_variant 0.31 rifampicin
nusG 734508 c.255C>G synonymous_variant 0.33 rifampicin
nusG 734863 p.Thr204Ser missense_variant 0.24 rifampicin
nusG 734895 c.642A>G synonymous_variant 0.22 rifampicin
nusG 734910 c.657C>G synonymous_variant 0.24 rifampicin
nusG 734913 c.660C>G synonymous_variant 0.24 rifampicin
rpoB 760181 c.375T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760184 c.378A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760196 c.390C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760199 c.393C>G synonymous_variant 0.19 rifampicin
rpoB 760415 c.609C>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760424 c.618C>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 760430 c.624T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 760508 c.702G>C synonymous_variant 0.21 rifampicin
rpoB 760511 c.705G>C synonymous_variant 0.18 rifampicin
rpoB 760522 p.Ser239Asn missense_variant 0.21 rifampicin Uncertain significance
rpoB 760547 c.741G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760551 c.745_746delTCinsAG synonymous_variant 0.21 rifampicin
rpoB 760611 c.805_807delTTGinsCC frameshift_variant&missense_variant 0.22 rifampicin
rpoB 760625 c.819C>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 760646 c.840C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760655 c.849A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760670 c.864G>C synonymous_variant 0.19 rifampicin
rpoB 760674 c.868T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760679 c.873A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760683 c.877T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761300 c.1494G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761318 c.1512G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 761327 c.1521A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 761633 c.1827G>C synonymous_variant 0.31 rifampicin
rpoB 761636 c.1830G>T synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 761648 c.1842T>C synonymous_variant 0.24 rifampicin
rpoB 762083 c.2277T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 762086 c.2280G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 762983 c.-387C>T upstream_gene_variant 0.19 rifampicin
rpoB 762995 c.3189G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 763028 c.3222T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>C synonymous_variant 0.22 rifampicin Not assoc w R
rpoB 763040 c.3234C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 763058 c.-312C>G upstream_gene_variant 0.35 rifampicin
rpoB 763070 c.3264T>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 763082 c.-288C>G upstream_gene_variant 0.35 rifampicin
rpoC 763103 c.-267G>C upstream_gene_variant 0.38 rifampicin
rpoB 763115 c.3309T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 763127 c.3321G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 763142 c.-228C>G upstream_gene_variant 0.15 rifampicin
rpoC 763160 c.-210G>T upstream_gene_variant 0.25 rifampicin
rpoB 763166 c.3360A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 763486 c.117T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 763501 c.132C>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 763528 c.159G>A synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 763573 c.204G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 763594 c.225C>T synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 763675 c.306C>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 764491 c.1122G>C synonymous_variant 0.15 rifampicin
rpoC 764497 c.1128A>G synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 764500 c.1131C>G synonymous_variant 0.16 rifampicin
rpoC 764650 c.1281G>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764677 c.1308C>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764701 c.1332C>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 764716 c.1347G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 764746 c.1377G>T synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 764752 c.1383G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764758 c.1389C>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 764764 c.1395T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764800 c.1431G>A synonymous_variant 0.16 rifampicin
rpoC 764803 c.1434C>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 764824 c.1455T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 764857 c.1488G>T synonymous_variant 0.2 rifampicin
rpoC 764858 c.1489T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764878 c.1509C>G synonymous_variant 0.27 rifampicin
rpoC 764995 c.1626C>G synonymous_variant 0.95 rifampicin Not assoc w R
rpoC 765478 c.2109T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 765480 p.Tyr704Phe missense_variant 0.27 rifampicin Uncertain significance
rpoC 765493 c.2124G>C synonymous_variant 0.28 rifampicin
rpoC 765499 c.2130C>A synonymous_variant 0.3 rifampicin
rpoC 765904 c.2535C>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 765937 c.2568T>C synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoC 766003 c.2634G>C synonymous_variant 0.21 rifampicin
rpoC 766009 c.2640G>T synonymous_variant 0.25 rifampicin
rpoC 766012 c.2643C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 766459 c.3090G>C synonymous_variant 0.23 rifampicin
rpoC 766471 c.3102G>C synonymous_variant 0.21 rifampicin
rpoC 766483 c.3114G>C synonymous_variant 0.19 rifampicin
rpoC 766486 c.3117A>G synonymous_variant 0.19 rifampicin
rpoC 766492 c.3123T>G synonymous_variant 0.2 rifampicin
rpoC 766493 p.Gly1042Asn missense_variant 0.2 rifampicin
rpoC 766517 p.Thr1050Ser missense_variant 0.22 rifampicin
rpoC 766525 c.3156G>T synonymous_variant 0.2 rifampicin
rpoC 766528 c.3159T>G synonymous_variant 0.21 rifampicin
rpoC 766530 p.Arg1054Gln missense_variant 0.2 rifampicin
rpoC 766540 p.Asp1057Glu missense_variant 0.23 rifampicin
rpoC 766543 c.3174C>T synonymous_variant 0.23 rifampicin
rpoC 766549 c.3180G>C synonymous_variant 0.19 rifampicin
rpoC 766570 c.3201T>C synonymous_variant 0.21 rifampicin
rpoC 766573 c.3204T>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 766582 c.3213C>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 766585 c.3216T>C synonymous_variant 0.24 rifampicin
rpoC 766607 p.Ile1080Leu missense_variant 0.26 rifampicin
rpoC 766618 c.3249G>T synonymous_variant 0.25 rifampicin
rpoC 766624 c.3255G>C synonymous_variant 0.24 rifampicin
rpoC 766630 c.3261G>T synonymous_variant 0.24 rifampicin
rpoC 766634 p.Phe1089Ile missense_variant 0.25 rifampicin
rpoC 766645 c.3276A>G synonymous_variant 0.16 rifampicin
rpoC 766672 c.3303T>C synonymous_variant 0.2 rifampicin
rpoC 766690 c.3321G>C synonymous_variant 0.26 rifampicin
rpoC 766694 c.3325_3327delCAGinsGC frameshift_variant&missense_variant 0.26 rifampicin
rpoC 766702 c.3333G>C synonymous_variant 0.26 rifampicin
rpoC 766708 c.3339A>G synonymous_variant 0.24 rifampicin
rpoC 766711 c.3342C>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 766720 c.3351C>T synonymous_variant 0.19 rifampicin
rpoC 766726 c.3357T>C synonymous_variant 0.26 rifampicin
rpoC 766732 c.3363G>T synonymous_variant 0.27 rifampicin
rpoC 766738 c.3369G>T synonymous_variant 0.28 rifampicin
rpoC 766747 c.3378C>T synonymous_variant 0.29 rifampicin
rpoC 766750 c.3381C>G synonymous_variant 0.31 rifampicin
rpoC 766753 c.3384C>T synonymous_variant 0.32 rifampicin
rpoC 766765 c.3396A>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 766774 c.3405T>C synonymous_variant 0.35 rifampicin
rpoC 766776 p.Arg1136His missense_variant 0.35 rifampicin
rpoC 766798 c.3429C>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 766804 c.3435A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 766807 c.3438T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 766837 c.3468G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 767180 p.Ala1271Gln missense_variant 0.17 rifampicin
rpoC 767191 c.3822C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
mmpL5 775639 p.Ile948Val missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
mmpL5 775915 p.Ala856Ser missense_variant 0.2 clofazimine
bedaquiline
mmpL5 775916 c.2565T>C synonymous_variant 0.26 clofazimine
bedaquiline
mmpL5 775922 c.2559G>C synonymous_variant 0.27 clofazimine
bedaquiline
mmpL5 775943 c.2538C>G synonymous_variant 0.14 clofazimine
bedaquiline
mmpL5 775946 c.2535C>G synonymous_variant 0.31 clofazimine
bedaquiline
mmpL5 775951 c.2530C>T synonymous_variant 0.45 clofazimine
bedaquiline
mmpL5 775966 p.Ala839Ser missense_variant 0.36 clofazimine
bedaquiline
mmpL5 775975 p.Leu836Met missense_variant 0.38 clofazimine
bedaquiline
mmpL5 775981 p.Leu834Met missense_variant 0.3 clofazimine
bedaquiline
mmpL5 775991 c.2490G>A synonymous_variant 0.25 clofazimine
bedaquiline
mmpL5 775997 c.2484T>G synonymous_variant 0.24 clofazimine
bedaquiline
mmpL5 776000 c.2479_2481delCTGinsAC frameshift_variant&missense_variant 0.24 clofazimine Uncertain significance
bedaquiline Uncertain significance
mmpL5 776009 c.2472A>G synonymous_variant 0.28 clofazimine
bedaquiline
mmpL5 776021 c.2460G>A synonymous_variant 0.4 clofazimine
bedaquiline
mmpL5 776024 c.2457G>C synonymous_variant 0.41 clofazimine
bedaquiline
mmpL5 776030 c.2451G>C synonymous_variant 0.43 clofazimine
bedaquiline
mmpL5 776060 c.2421C>G synonymous_variant 0.28 clofazimine
bedaquiline
mmpL5 776072 c.2409C>G synonymous_variant 0.21 clofazimine
bedaquiline
mmpL5 776075 c.2406C>G synonymous_variant 0.21 clofazimine
bedaquiline
mmpL5 776080 p.Ala801Ser missense_variant 0.27 clofazimine
bedaquiline
mmpL5 776645 c.1836C>G synonymous_variant 0.18 clofazimine
bedaquiline
mmpL5 776650 p.Asp611Asn missense_variant 0.2 clofazimine
bedaquiline
mmpL5 776654 c.1827A>C synonymous_variant 0.19 clofazimine
bedaquiline
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781631 c.72G>C synonymous_variant 0.18 streptomycin
rpsL 781655 c.96T>C synonymous_variant 0.21 streptomycin
rpsL 781658 c.99A>G synonymous_variant 0.22 streptomycin
rpsL 781676 c.117C>G synonymous_variant 0.24 streptomycin
rpsL 781682 c.123T>C synonymous_variant 0.24 streptomycin
rpsL 781709 c.150G>C synonymous_variant 0.25 streptomycin Not assoc w R - Interim
rpsL 781715 c.156T>C synonymous_variant 0.24 streptomycin
rpsL 781718 c.159C>G synonymous_variant 0.24 streptomycin
rpsL 781728 c.169T>C synonymous_variant 0.26 streptomycin
rpsL 781733 c.174G>C synonymous_variant 0.31 streptomycin
rpsL 781736 c.177T>C synonymous_variant 0.33 streptomycin
rpsL 781751 c.192G>C synonymous_variant 0.35 streptomycin
rpsL 781754 c.195G>A synonymous_variant 0.36 streptomycin Not assoc w R - Interim
rpsL 781760 c.201T>C synonymous_variant 0.36 streptomycin
rpsL 781766 c.207C>T synonymous_variant 0.32 streptomycin Not assoc w R - Interim
rpsL 781811 c.252C>T synonymous_variant 0.17 streptomycin
rpsL 781814 c.255C>T synonymous_variant 0.15 streptomycin
rpsL 781865 c.306G>C synonymous_variant 0.2 streptomycin
rpsL 781868 c.309T>C synonymous_variant 0.2 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.2 streptomycin
rpsL 781880 c.321C>G synonymous_variant 0.27 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.26 streptomycin
rpsL 781895 c.336G>A synonymous_variant 0.25 streptomycin
rpsL 781898 c.339A>G synonymous_variant 0.24 streptomycin
rpsL 781907 c.348T>C synonymous_variant 0.24 streptomycin
rpsL 781916 c.357T>C synonymous_variant 0.28 streptomycin
rpsL 781929 p.Gly124Ser missense_variant 0.28 streptomycin Uncertain significance
rplC 800516 c.-293G>C upstream_gene_variant 0.18 linezolid
rplC 800531 c.-278T>C upstream_gene_variant 0.15 linezolid
rplC 800537 c.-272C>G upstream_gene_variant 0.15 linezolid
rplC 800540 c.-269T>C upstream_gene_variant 0.16 linezolid
rplC 800546 c.-263T>C upstream_gene_variant 0.17 linezolid
rplC 800564 c.-245C>G upstream_gene_variant 0.15 linezolid
rplC 800567 c.-242A>G upstream_gene_variant 0.15 linezolid
rplC 800570 c.-239C>G upstream_gene_variant 0.15 linezolid
rplC 800574 c.-235_-234delGTinsAC upstream_gene_variant 0.14 linezolid
rplC 800594 c.-215C>G upstream_gene_variant 0.17 linezolid
rplC 800597 c.-212A>G upstream_gene_variant 0.18 linezolid
rplC 800600 c.-209G>C upstream_gene_variant 0.17 linezolid
rplC 800603 c.-206G>C upstream_gene_variant 0.17 linezolid
rplC 800612 c.-197A>G upstream_gene_variant 0.16 linezolid
rplC 800618 c.-191T>C upstream_gene_variant 0.2 linezolid
rplC 800654 c.-155T>C upstream_gene_variant 0.19 linezolid
rplC 800672 c.-137G>T upstream_gene_variant 0.21 linezolid
rplC 800690 c.-119C>T upstream_gene_variant 0.21 linezolid
rplC 800693 c.-116A>T upstream_gene_variant 0.21 linezolid
rplC 800715 c.-94A>C upstream_gene_variant 0.23 linezolid
rplC 800720 c.-89T>C upstream_gene_variant 0.24 linezolid
rplC 800723 c.-86C>G upstream_gene_variant 0.22 linezolid
rplC 800738 c.-71T>C upstream_gene_variant 0.17 linezolid
fbiC 1303548 c.618G>C synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1303551 c.621G>T synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1304613 c.1683T>G synonymous_variant 0.16 clofazimine
pretomanid
delamanid
sigE 1364865 c.453G>C synonymous_variant 0.14 pyrazinamide
sigE 1364867 p.Ala152Gly missense_variant 0.14 pyrazinamide
atpE 1461050 c.6C>T synonymous_variant 0.17 bedaquiline
atpE 1461056 c.12T>A synonymous_variant 0.16 bedaquiline
atpE 1461089 c.45G>C synonymous_variant 0.21 bedaquiline
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472380 n.535G>C non_coding_transcript_exon_variant 0.33 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472445 n.601_604delTCTC non_coding_transcript_exon_variant 0.21 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472451 n.606_607insCGGG non_coding_transcript_exon_variant 0.21 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472460 n.615T>C non_coding_transcript_exon_variant 0.21 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472461 n.616G>C non_coding_transcript_exon_variant 0.21 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472463 n.618G>C non_coding_transcript_exon_variant 0.22 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472464 n.619A>G non_coding_transcript_exon_variant 0.23 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472489 n.644A>T non_coding_transcript_exon_variant 0.43 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472973 n.1128A>T non_coding_transcript_exon_variant 0.41 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrl 1474287 n.630_635delTCCTTTinsCTCGACTTG non_coding_transcript_exon_variant 0.27 capreomycin
linezolid
rrl 1474294 n.638_649delCTCTCCGGAGGA non_coding_transcript_exon_variant 0.28 capreomycin
linezolid
rrl 1474308 n.651G>T non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474310 n.653T>G non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1474362 n.705A>G non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474374 n.717T>G non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid
rrl 1474387 n.730C>T non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474672 n.1015C>T non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474673 n.1016T>C non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474676 n.1019T>A non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474708 n.1052_1053insACAAG non_coding_transcript_exon_variant 0.52 capreomycin
linezolid
rrl 1474711 n.1055_1058delGTGT non_coding_transcript_exon_variant 0.5 capreomycin
linezolid
rrl 1474717 n.1060A>G non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid
rrl 1474720 n.1063C>T non_coding_transcript_exon_variant 0.5 capreomycin
linezolid
rrl 1474753 n.1096A>G non_coding_transcript_exon_variant 0.47 capreomycin Uncertain significance
linezolid
rrl 1474760 n.1103A>G non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.51 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.45 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475429 n.1772G>A non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475452 n.1795C>A non_coding_transcript_exon_variant 0.53 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475479 n.1822C>T non_coding_transcript_exon_variant 0.48 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475480 n.1823A>G non_coding_transcript_exon_variant 0.48 capreomycin
linezolid
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475544 n.1887A>T non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475545 n.1888T>G non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475753 n.2096C>G non_coding_transcript_exon_variant 0.54 capreomycin Uncertain significance
linezolid
rrl 1475762 n.2105G>T non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid
rrl 1475763 n.2106C>T non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid
rrl 1475764 n.2107A>C non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid
rrl 1475765 n.2108A>G non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid
rrl 1475775 n.2118G>T non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475916 n.2259C>T non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.45 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1475989 n.2332T>A non_coding_transcript_exon_variant 0.44 capreomycin
linezolid
rrl 1475997 n.2340A>T non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476030 n.2373A>G non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid
rrl 1476032 n.2375C>G non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1476033 n.2376T>G non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1476035 n.2378G>C non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid
rrl 1476044 n.2387T>G non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid
rrl 1476046 n.2389G>T non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1476047 n.2390G>T non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1476049 n.2392C>T non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476088 n.2431A>T non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1476115 n.2458T>C non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476131 n.2474C>T non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476597 n.2940G>A non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid
inhA 1674864 c.663C>T synonymous_variant 0.37 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
inhA 1674870 c.669T>C synonymous_variant 0.35 ethionamide
isoniazid
inhA 1674876 c.675C>G synonymous_variant 0.33 ethionamide
isoniazid
inhA 1674879 c.678T>G synonymous_variant 0.32 ethionamide
isoniazid
inhA 1674904 p.Ala235Pro missense_variant 0.21 ethionamide
isoniazid
rpsA 1833745 c.204G>T synonymous_variant 0.15 pyrazinamide
rpsA 1833772 c.231C>T synonymous_variant 0.3 pyrazinamide
rpsA 1833778 c.237C>T synonymous_variant 0.28 pyrazinamide
rpsA 1833781 c.240T>G synonymous_variant 0.25 pyrazinamide
rpsA 1833790 c.249T>C synonymous_variant 0.17 pyrazinamide
rpsA 1833793 c.252C>T synonymous_variant 0.17 pyrazinamide
rpsA 1833808 c.267G>C synonymous_variant 0.23 pyrazinamide
rpsA 1833811 c.270G>T synonymous_variant 0.21 pyrazinamide
rpsA 1833820 c.279G>A synonymous_variant 0.24 pyrazinamide
rpsA 1833832 c.291G>A synonymous_variant 0.2 pyrazinamide
rpsA 1833838 c.297G>C synonymous_variant 0.19 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.19 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.2 pyrazinamide
rpsA 1833949 c.408T>C synonymous_variant 0.24 pyrazinamide
rpsA 1833970 c.429G>C synonymous_variant 0.22 pyrazinamide
rpsA 1833976 c.435C>T synonymous_variant 0.25 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.25 pyrazinamide
rpsA 1833991 c.450C>A synonymous_variant 0.28 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.23 pyrazinamide
rpsA 1834009 c.468C>T synonymous_variant 0.2 pyrazinamide
rpsA 1834012 c.471G>C synonymous_variant 0.2 pyrazinamide
rpsA 1834261 c.720A>G synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
rpsA 1834264 c.723G>C synonymous_variant 0.22 pyrazinamide
rpsA 1834282 c.741C>T synonymous_variant 0.16 pyrazinamide
rpsA 1834303 c.762T>G synonymous_variant 0.15 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.15 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 0.23 pyrazinamide Not assoc w R - Interim
rpsA 1834361 c.820T>C synonymous_variant 0.27 pyrazinamide
rpsA 1834366 c.825A>G synonymous_variant 0.27 pyrazinamide Not assoc w R - Interim
rpsA 1834378 c.837T>C synonymous_variant 0.28 pyrazinamide Not assoc w R - Interim
rpsA 1834387 c.846C>T synonymous_variant 0.27 pyrazinamide
rpsA 1834396 c.855G>C synonymous_variant 0.29 pyrazinamide
rpsA 1834411 c.870T>C synonymous_variant 0.18 pyrazinamide
rpsA 1834423 c.882G>C synonymous_variant 0.31 pyrazinamide
rpsA 1834543 c.1002C>G synonymous_variant 0.16 pyrazinamide
rpsA 1834600 c.1059G>C synonymous_variant 0.33 pyrazinamide
rpsA 1834606 c.1065C>T synonymous_variant 0.32 pyrazinamide
rpsA 1834609 c.1068T>C synonymous_variant 0.34 pyrazinamide
rpsA 1834619 c.1078T>C synonymous_variant 0.42 pyrazinamide
rpsA 1834633 c.1092A>G synonymous_variant 0.42 pyrazinamide
rpsA 1834639 c.1098T>C synonymous_variant 0.4 pyrazinamide
rpsA 1834666 c.1125G>C synonymous_variant 0.19 pyrazinamide
rpsA 1834667 p.Ala376Ser missense_variant 0.19 pyrazinamide
rpsA 1834678 c.1137C>T synonymous_variant 0.19 pyrazinamide
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
kasA 2518651 c.537C>G synonymous_variant 0.24 isoniazid
kasA 2518656 p.Ala181Gly missense_variant 0.24 isoniazid
kasA 2518672 c.558G>C synonymous_variant 0.29 isoniazid
kasA 2518678 c.564C>T synonymous_variant 0.3 isoniazid
kasA 2518711 c.597A>G synonymous_variant 0.25 isoniazid
kasA 2519137 c.1023T>G synonymous_variant 0.5 isoniazid
kasA 2519143 c.1029G>C synonymous_variant 0.37 isoniazid
kasA 2519152 c.1038G>C synonymous_variant 0.37 isoniazid
kasA 2519158 c.1044C>G synonymous_variant 0.32 isoniazid
Rv2477c 2782453 c.1590C>T synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782465 c.1578G>A synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782480 c.1563G>A synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782486 c.1557G>A synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783047 p.Asp332Glu missense_variant 0.14 ethambutol Uncertain significance
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin Uncertain significance
amikacin
Rv2477c 2783051 p.Tyr331Phe missense_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783053 c.990C>T synonymous_variant 0.14 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783059 c.984T>C synonymous_variant 0.14 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783068 p.Asp325Glu missense_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783077 c.966T>G synonymous_variant 0.15 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783083 c.960G>C synonymous_variant 0.16 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783992 c.51T>C synonymous_variant 0.24 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin
Rv2752c 3065249 c.943T>C synonymous_variant 0.31 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
thyX 3067685 c.261A>G synonymous_variant 0.21 para-aminosalicylic_acid
thyX 3067688 c.258G>C synonymous_variant 0.21 para-aminosalicylic_acid
thyA 3073868 p.Thr202Ala missense_variant 0.91 para-aminosalicylic_acid
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
Rv3236c 3612009 p.Ala370Thr missense_variant 1.0 pyrazinamide Not assoc w R
mtrB 3625065 p.Met517Leu missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
mtrB 3625806 c.808A>C synonymous_variant 0.18 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625837 c.-927C>T upstream_gene_variant 0.24 bedaquiline
rifampicin
mtrB 3626684 c.-71G>A upstream_gene_variant 0.18 bedaquiline
rifampicin
mtrA 3626804 c.546A>G synonymous_variant 0.28 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3626825 c.525T>A synonymous_variant 0.43 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3626846 c.504G>A synonymous_variant 0.36 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626849 c.-236C>T upstream_gene_variant 0.36 bedaquiline
rifampicin
mtrB 3626852 c.-239G>A upstream_gene_variant 0.36 bedaquiline
rifampicin
mtrB 3626857 c.-244T>C upstream_gene_variant 0.38 bedaquiline
rifampicin
mtrB 3626858 c.-245A>G upstream_gene_variant 0.38 bedaquiline
rifampicin
mtrB 3626861 c.-248C>G upstream_gene_variant 0.38 bedaquiline
rifampicin
mtrB 3626876 c.-263A>G upstream_gene_variant 0.42 bedaquiline
rifampicin
mtrB 3626890 c.-277T>C upstream_gene_variant 0.22 bedaquiline
rifampicin
mtrB 3626894 c.-281C>T upstream_gene_variant 0.21 bedaquiline
rifampicin
mtrB 3627263 c.-650C>A upstream_gene_variant 0.14 bedaquiline
rifampicin
alr 3840719 c.702A>G synonymous_variant 1.0 cycloserine
rpoA 3877656 c.852T>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3877818 c.690A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoA 3877836 c.672A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoA 3877839 c.669G>T synonymous_variant 0.25 rifampicin
rpoA 3877842 c.666A>G synonymous_variant 0.23 rifampicin
rpoA 3877848 c.660C>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoA 3877856 c.652T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoA 3877875 c.633T>G synonymous_variant 0.29 rifampicin
rpoA 3877881 c.627G>C synonymous_variant 0.25 rifampicin
rpoA 3877884 c.624G>C synonymous_variant 0.25 rifampicin
rpoA 3877893 c.615C>T synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoA 3877900 p.Ser203Thr missense_variant 0.24 rifampicin
rpoA 3877905 c.603A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoA 3877908 c.600T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoA 3877920 c.588G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3877926 c.582G>C synonymous_variant 0.22 rifampicin
rpoA 3877962 c.546G>C synonymous_variant 0.15 rifampicin
rpoA 3877971 p.Asp179Glu missense_variant 0.17 rifampicin Uncertain significance
rpoA 3877989 c.519A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3878118 c.390T>C synonymous_variant 0.17 rifampicin
rpoA 3878130 c.378C>G synonymous_variant 0.19 rifampicin
rpoA 3878142 p.Gly122Glu missense_variant 0.24 rifampicin
rpoA 3878157 c.351C>G synonymous_variant 0.24 rifampicin
rpoA 3878160 c.348C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3878163 c.345C>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3878175 c.333G>C synonymous_variant 0.19 rifampicin
rpoA 3878187 c.321C>G synonymous_variant 0.17 rifampicin
rpoA 3878193 c.315T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoA 3878202 c.306G>C synonymous_variant 0.18 rifampicin
rpoA 3878217 c.291A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3878247 c.261G>C synonymous_variant 0.16 rifampicin
rpoA 3878292 c.216T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3878298 c.210A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3878310 c.198G>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoA 3878313 c.195G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoA 3878346 c.162T>C synonymous_variant 0.17 rifampicin
rpoA 3879073 c.-566A>G upstream_gene_variant 0.28 rifampicin
rpoA 3879078 c.-571A>C upstream_gene_variant 0.28 rifampicin
rpoA 3879079 c.-572A>G upstream_gene_variant 0.28 rifampicin
rpoA 3879088 c.-581A>C upstream_gene_variant 0.25 rifampicin
rpoA 3879094 c.-587T>C upstream_gene_variant 0.21 rifampicin
rpoA 3879136 c.-629A>G upstream_gene_variant 0.17 rifampicin
rpoA 3879178 c.-671T>C upstream_gene_variant 0.17 rifampicin
clpC1 4038287 c.2418C>T synonymous_variant 1.0 pyrazinamide Not assoc w R
clpC1 4038551 c.2154C>G synonymous_variant 0.25 pyrazinamide
clpC1 4038640 p.Asp689Asn missense_variant 0.14 pyrazinamide
clpC1 4038671 c.2034T>G synonymous_variant 0.15 pyrazinamide Not assoc w R - Interim
clpC1 4038683 c.2022T>C synonymous_variant 0.14 pyrazinamide Not assoc w R - Interim
clpC1 4038701 c.2004G>C synonymous_variant 0.16 pyrazinamide
clpC1 4038704 c.2001T>C synonymous_variant 0.17 pyrazinamide
clpC1 4038707 c.1998C>G synonymous_variant 0.17 pyrazinamide
clpC1 4038710 c.1995G>C synonymous_variant 0.17 pyrazinamide
clpC1 4038713 c.1992T>C synonymous_variant 0.17 pyrazinamide
clpC1 4038749 c.1956C>T synonymous_variant 0.16 pyrazinamide Not assoc w R - Interim
clpC1 4038767 c.1938G>T synonymous_variant 0.16 pyrazinamide
clpC1 4038773 c.1932T>C synonymous_variant 0.19 pyrazinamide
clpC1 4038782 c.1923G>C synonymous_variant 0.17 pyrazinamide
clpC1 4038791 c.1914G>C synonymous_variant 0.15 pyrazinamide
clpC1 4038812 c.1893T>C synonymous_variant 0.19 pyrazinamide
clpC1 4038815 c.1890G>C synonymous_variant 0.19 pyrazinamide
clpC1 4038941 c.1764G>C synonymous_variant 0.15 pyrazinamide
clpC1 4039274 c.1431G>C synonymous_variant 0.23 pyrazinamide Not assoc w R - Interim
clpC1 4039277 c.1428C>G synonymous_variant 0.21 pyrazinamide
clpC1 4039280 c.1425G>C synonymous_variant 0.21 pyrazinamide
clpC1 4039286 c.1419T>G synonymous_variant 0.19 pyrazinamide
clpC1 4039517 c.1188C>G synonymous_variant 0.18 pyrazinamide
clpC1 4040693 c.12A>T synonymous_variant 0.29 pyrazinamide
glpK 4138532 c.1224G>C synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138676 c.1080T>C synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138681 p.Met359Val missense_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138730 c.1026C>T synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
embC 4241039 p.Asp393Asn missense_variant 0.26 ethambutol
embC 4241047 c.1185C>T synonymous_variant 0.25 ethambutol Not assoc w R - Interim
embC 4241050 c.1188T>G synonymous_variant 0.25 ethambutol
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
embB 4247500 c.987C>G synonymous_variant 0.16 ethambutol
embB 4247512 c.999T>C synonymous_variant 0.29 ethambutol
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 capreomycin
amikacin
kanamycin
gid 4408156 p.Leu16Arg missense_variant 1.0 streptomycin Not assoc w R